KEGG   PATHWAY: svs04120
Entry
svs04120                    Pathway                                
Name
Ubiquitin mediated proteolysis - Setaria viridis (green foxtail)
Description
Protein ubiquitination plays an important role in eukaryotic cellular processes. It mainly functions as a signal for 26S proteasome dependent protein degradation. The addition of ubiquitin to proteins being degraded is performed by a reaction cascade consisting of three enzymes, named E1 (ubiquitin activating enzyme), E2 (ubiquitin conjugating enzyme), and E3 (ubiquitin ligase). Each E3 has specificity to its substrate, or proteins to be targeted by ubiquitination. Many E3s are discovered in eukaryotes and they are classified into four types: HECT type, U-box type, single RING-finger type, and multi-subunit RING-finger type. Multi-subunit RING-finger E3s are exemplified by cullin-Rbx E3s and APC/C. They consist of a RING-finger-containing subunit (RBX1 or RBX2) that functions to bind E2s, a scaffold-like cullin molecule, adaptor proteins, and a target recognizing subunit that binds substrates.
Class
Genetic Information Processing; Folding, sorting and degradation
Pathway map
svs04120  Ubiquitin mediated proteolysis
svs04120

Other DBs
GO: 0016567
Organism
Setaria viridis (green foxtail) [GN:svs]
Gene
117835623  polyubiquitin-like [KO:K04551]
117848754  polyubiquitin-like [KO:K08770]
117833993  polyubiquitin-like [KO:K08770]
117836027  polyubiquitin-like [KO:K08770]
117843114  polyubiquitin [KO:K08770]
117859344  polyubiquitin [KO:K08770]
117849355  polyubiquitin [KO:K08770]
117849365  polyubiquitin [KO:K08770]
117852901  polyubiquitin [KO:K08770]
117845497  ubiquitin-60S ribosomal protein L40-1 [KO:K02927]
117846512  ubiquitin-like [KO:K02927]
117846513  ubiquitin-like [KO:K02927]
117834721  ubiquitin-like [KO:K02927]
117842128  ubiquitin-like [KO:K02927]
117837757  ubiquitin-60S ribosomal protein L40-1 [KO:K02927]
117843441  ubiquitin-like [KO:K02927]
117835329  ubiquitin-40S ribosomal protein S27a-like [KO:K02977]
117864076  ubiquitin-40S ribosomal protein S27a-2 [KO:K02977]
117857384  ubiquitin-40S ribosomal protein S27a-1 [KO:K02977]
117837769  ubiquitin-activating enzyme E1 3-like isoform X1 [KO:K03178] [EC:6.2.1.45]
117843525  ubiquitin-activating enzyme E1 3 isoform X1 [KO:K03178] [EC:6.2.1.45]
117863571  ubiquitin-activating enzyme E1 2-like [KO:K03178] [EC:6.2.1.45]
117867032  ubiquitin-activating enzyme E1 2 [KO:K03178] [EC:6.2.1.45]
117833482  SUMO-activating enzyme subunit 1A-like [KO:K10684] [EC:6.2.1.45]
117842491  SUMO-activating enzyme subunit 2 [KO:K10685] [EC:6.2.1.45]
117858615  NEDD8-activating enzyme E1 catalytic subunit [KO:K10686] [EC:6.2.1.64]
117840942  ubiquitin-conjugating enzyme E2 2 [KO:K10573] [EC:2.3.2.23]
117843420  ubiquitin-conjugating enzyme E2 2-like [KO:K10573] [EC:2.3.2.23]
117857025  ubiquitin-conjugating enzyme E2 2-like [KO:K10573] [EC:2.3.2.23]
117858384  ubiquitin-conjugating enzyme E2 20-like [KO:K06688] [EC:2.3.2.23]
117846087  ubiquitin-conjugating enzyme E2 28-like [KO:K06689] [EC:2.3.2.23]
117849525  ubiquitin-conjugating enzyme E2-17 kDa [KO:K06689] [EC:2.3.2.23]
117847959  ubiquitin-conjugating enzyme E2 28 [KO:K06689] [EC:2.3.2.23]
117844742  ubiquitin-conjugating enzyme E2 28-like [KO:K06689] [EC:2.3.2.23]
117850941  ubiquitin-conjugating enzyme E2 11 isoform X1 [KO:K06689] [EC:2.3.2.23]
117855504  ubiquitin-conjugating enzyme E2 5A [KO:K06689] [EC:2.3.2.23]
117856346  ubiquitin-conjugating enzyme E2 28-like [KO:K06689] [EC:2.3.2.23]
117851246  ubiquitin-conjugating enzyme E2 5B [KO:K06689] [EC:2.3.2.23]
117850778  ubiquitin-conjugating enzyme E2 7 [KO:K10575] [EC:2.3.2.23]
117857620  ubiquitin-conjugating enzyme E2 7-like isoform X1 [KO:K10575] [EC:2.3.2.23]
117839599  ubiquitin-conjugating enzyme E2 4-like [KO:K10576] [EC:2.3.2.23]
117840086  ubiquitin-conjugating enzyme E2 4-like [KO:K10576] [EC:2.3.2.23]
117841030  SUMO-conjugating enzyme SCE1-like [KO:K10577]
117838915  SUMO-conjugating enzyme SCE1 [KO:K10577]
117862795  SUMO-conjugating enzyme SCE1-like [KO:K10577]
117863275  SUMO-conjugating enzyme SCE1-like [KO:K10577]
117837309  ubiquitin-conjugating enzyme E2 32 [KO:K10578] [EC:2.3.2.23]
117852263  ubiquitin-conjugating enzyme E2 34-like [KO:K04554] [EC:2.3.2.23]
117857175  ubiquitin-conjugating enzyme E2 27 [KO:K04649] [EC:2.3.2.23]
117844634  NEDD8-conjugating enzyme Ubc12-like [KO:K10579] [EC:2.3.2.34]
117861239  NEDD8-conjugating enzyme Ubc12-like [KO:K10579] [EC:2.3.2.34]
117846310  ubiquitin-conjugating enzyme E2 36-like isoform X1 [KO:K10580] [EC:2.3.2.23]
117850500  ubiquitin-conjugating enzyme E2 36 [KO:K10580] [EC:2.3.2.23]
117856891  ubiquitin-conjugating enzyme E2 36-like [KO:K10580] [EC:2.3.2.23]
117848022  probable ubiquitin-conjugating enzyme E2 23 [KO:K10581] [EC:2.3.2.24]
117848024  probable ubiquitin-conjugating enzyme E2 23 [KO:K10581] [EC:2.3.2.24]
117857905  putative ubiquitin-conjugating enzyme E2 38 [KO:K10581] [EC:2.3.2.24]
117849024  probable ubiquitin-conjugating enzyme E2 24 [KO:K10581] [EC:2.3.2.24]
117849291  probable ubiquitin-conjugating enzyme E2 23 [KO:K10581] [EC:2.3.2.24]
117849293  probable ubiquitin-conjugating enzyme E2 23 [KO:K10581] [EC:2.3.2.24]
117850019  probable ubiquitin-conjugating enzyme E2 25 [KO:K10581] [EC:2.3.2.24]
117856450  putative ubiquitin-conjugating enzyme E2 38 [KO:K10581] [EC:2.3.2.24]
117858464  probable ubiquitin-conjugating enzyme E2 23 [KO:K10581] [EC:2.3.2.24]
117858949  putative ubiquitin-conjugating enzyme E2 38 [KO:K10581] [EC:2.3.2.24]
117852279  ubiquitin-conjugating enzyme E2 22-like [KO:K10583] [EC:2.3.2.23]
117852280  ubiquitin-conjugating enzyme E2 22-like [KO:K10583] [EC:2.3.2.23]
117840782  ubiquitin-conjugating enzyme 15-like [KO:K10688] [EC:2.3.2.23 2.3.2.25]
117848108  ubiquitin-conjugating enzyme 15 [KO:K10688] [EC:2.3.2.23 2.3.2.25]
117836197  E3 ubiquitin-protein ligase UPL7 [KO:K10588] [EC:2.3.2.26]
117863845  E3 ubiquitin-protein ligase UPL6 [KO:K10589] [EC:2.3.2.26]
117847281  E3 ubiquitin-protein ligase UPL4-like isoform X1 [KO:K10590] [EC:2.3.2.26]
117837703  E3 ubiquitin-protein ligase UPL3-like [KO:K10590] [EC:2.3.2.26]
117849875  E3 ubiquitin-protein ligase UPL4 [KO:K10590] [EC:2.3.2.26]
117865349  E3 ubiquitin-protein ligase UPL3-like isoform X1 [KO:K10590] [EC:2.3.2.26]
117845479  E3 ubiquitin-protein ligase UPL1-like isoform X1 [KO:K10592] [EC:2.3.2.26]
117848609  E3 ubiquitin-protein ligase UPL1-like [KO:K10592] [EC:2.3.2.26]
117838336  probable ubiquitin conjugation factor E4 [KO:K10597] [EC:2.3.2.27]
117848566  E3 ubiquitin-protein ligase CHIP-like [KO:K09561] [EC:2.3.2.27]
117859736  E3 ubiquitin-protein ligase CHIP isoform X1 [KO:K09561] [EC:2.3.2.27]
117835527  peptidyl-prolyl cis-trans isomerase CYP65 [KO:K10598] [EC:5.2.1.8]
117839003  pre-mRNA-processing factor 19 [KO:K10599] [EC:2.3.2.27]
117839525  E3 ubiquitin-protein ligase SINAT2-like [KO:K04506] [EC:2.3.2.27]
117839771  E3 ubiquitin-protein ligase SINA-like 2 [KO:K04506] [EC:2.3.2.27]
117837612  E3 ubiquitin-protein ligase DIS1 [KO:K04506] [EC:2.3.2.27]
117845255  E3 ubiquitin-protein ligase DIS1-like [KO:K04506] [EC:2.3.2.27]
117861586  E3 ubiquitin-protein ligase SINAT5-like [KO:K04506] [EC:2.3.2.27]
117849884  putative E3 ubiquitin-protein ligase SINA-like 9 [KO:K04506] [EC:2.3.2.27]
117850048  E3 ubiquitin-protein ligase SINA-like 7 [KO:K04506] [EC:2.3.2.27]
117864875  uncharacterized protein LOC117864875 [KO:K04506] [EC:2.3.2.27]
117856141  putative E3 ubiquitin-protein ligase SINA-like 6 [KO:K04506] [EC:2.3.2.27]
117856162  E3 ubiquitin-protein ligase SINA-like 7 [KO:K04506] [EC:2.3.2.27]
117856164  putative E3 ubiquitin-protein ligase SINA-like 6 [KO:K04506] [EC:2.3.2.27]
117856167  putative E3 ubiquitin-protein ligase SINA-like 6 [KO:K04506] [EC:2.3.2.27]
117857983  E3 ubiquitin-protein ligase SINAT5-like [KO:K04506] [EC:2.3.2.27]
117858334  E3 ubiquitin-protein ligase SINA-like 5 [KO:K04506] [EC:2.3.2.27]
117858349  E3 ubiquitin-protein ligase SINA-like 10 [KO:K04506] [EC:2.3.2.27]
117858952  uncharacterized protein LOC117858952 [KO:K04506] [EC:2.3.2.27]
117849576  E3 ubiquitin-protein ligase SINAT5-like [KO:K04506] [EC:2.3.2.27]
117839617  E3 ubiquitin-protein ligase COP1 [KO:K10143] [EC:2.3.2.27]
117839350  E3 ubiquitin-protein ligase RZFP34-like [KO:K10144] [EC:2.3.2.27]
117836509  E3 ubiquitin-protein ligase SRFP1 isoform X1 [KO:K10144] [EC:2.3.2.27]
117838303  E3 ubiquitin-protein ligase RZFP34-like [KO:K10144] [EC:2.3.2.27]
117849555  E3 ubiquitin-protein ligase MIEL1-like isoform X1 [KO:K10144] [EC:2.3.2.27]
117856031  probable E3 ubiquitin-protein ligase RZFP34 [KO:K10144] [EC:2.3.2.27]
117852684  E4 SUMO-protein ligase PIAL2-like [KO:K04706] [EC:2.3.2.-]
117852997  ERAD-associated E3 ubiquitin-protein ligase HRD1-like isoform X1 [KO:K10601] [EC:2.3.2.27]
117858872  ERAD-associated E3 ubiquitin-protein ligase HRD1-like isoform X1 [KO:K10601] [EC:2.3.2.27]
117835140  E3 ubiquitin-protein ligase RBX1 [KO:K03868] [EC:2.3.2.32]
117856011  RING-box protein 1-like [KO:K03868] [EC:2.3.2.32]
117848410  cullin-1-like [KO:K03347]
117857013  cullin-1 [KO:K03347]
117858381  cullin-1-like [KO:K03347]
117833481  SKP1-like protein 1 [KO:K03094]
117836468  SKP1-like protein 13 [KO:K03094]
117841941  SKP1-like protein 1 [KO:K03094]
117837745  SKP1-like protein 1 [KO:K03094]
117844483  SKP1-like protein 1A [KO:K03094]
117844484  SKP1-like protein 1 [KO:K03094]
117844485  SKP1-like protein 1 [KO:K03094]
117845075  SKP1-like protein 20 [KO:K03094]
117849135  SKP1-like protein 5 [KO:K03094]
117851690  SKP1-like protein 1 [KO:K03094]
117854064  SKP1-like protein 1 [KO:K03094]
117856907  SKP1-like protein 1 [KO:K03094]
117858558  SKP1-like protein 1 isoform X1 [KO:K03094]
117849798  F-box protein SKP2A-like [KO:K03875]
117858997  F-box protein SKP2A-like [KO:K03875]
117839526  elongin-C [KO:K03872]
117837964  cullin-3A-like [KO:K03869]
117859698  cullin-3A-like [KO:K03869]
117839128  cullin-4 [KO:K10609]
117848956  DNA damage-binding protein 1 [KO:K10610]
117856088  DNA damage-binding protein 2 [KO:K10140]
117855977  WD repeat-containing protein ATCSA-1-like isoform X1 [KO:K10570]
117856993  light-mediated development protein DET1 [KO:K10571]
117863907  anaphase-promoting complex subunit 2 [KO:K03349]
117840973  cell division cycle 20.2, cofactor of APC complex-like [KO:K03363]
117834363  cell division cycle 20.2, cofactor of APC complex-like [KO:K03363]
117863971  cell division cycle 20.2, cofactor of APC complex-like [KO:K03363]
117840037  protein FIZZY-RELATED 2-like [KO:K03364]
117857374  protein FIZZY-RELATED 3 [KO:K03364]
117847922  anaphase-promoting complex subunit 1 isoform X1 [KO:K03348]
117852149  cell division cycle protein 27 homolog B isoform X1 [KO:K03350]
117840692  anaphase-promoting complex subunit 4 isoform X1 [KO:K03351]
117850053  anaphase-promoting complex subunit 5 [KO:K03352]
117836562  anaphase-promoting complex subunit 6 [KO:K03353]
117865268  anaphase-promoting complex subunit 8 [KO:K03355]
117847126  anaphase-promoting complex subunit 10-like [KO:K03357]
117851280  anaphase-promoting complex subunit 10-like [KO:K03357]
Reference
PMID:16922370
  Authors
Kamura T.
  Title
[Cullin-based E3 family]
  Journal
Tanpakushitsu Kakusan Koso 51:1167-72 (2006)
Reference
PMID:16922408
  Authors
Matsuda N.
  Title
[Overview: hereditary disorders caused by dysfunction of ubiquitylation]
  Journal
Tanpakushitsu Kakusan Koso 51:1402-7 (2006)
Reference
PMID:16922367
  Authors
Tokunaga F.
  Title
[E2 ubiquitin-conjugating enzymes: structures and functions]
  Journal
Tanpakushitsu Kakusan Koso 51:1150-6 (2006)
Reference
PMID:16816840
  Authors
Nalepa G, Rolfe M, Harper JW.
  Title
Drug discovery in the ubiquitin-proteasome system.
  Journal
Nat Rev Drug Discov 5:596-613 (2006)
DOI:10.1038/nrd2056
Reference
PMID:16405856
  Authors
Hsu YJ, Goodman SR.
  Title
Spectrin and ubiquitination: a review.
  Journal
Cell Mol Biol (Noisy-le-grand) Suppl 51:OL801-7 (2005)
Reference
PMID:12944364
  Authors
Hatakeyama S, Nakayama KI.
  Title
Ubiquitylation as a quality control system for intracellular proteins.
  Journal
J Biochem 134:1-8 (2003)
DOI:10.1093/jb/mvg106
Reference
PMID:17588513
  Authors
Lee J, Zhou P.
  Title
DCAFs, the missing link of the CUL4-DDB1 ubiquitin ligase.
  Journal
Mol Cell 26:775-80 (2007)
DOI:10.1016/j.molcel.2007.06.001
Related
pathway
svs03050  Proteasome
KO pathway
ko04120   
LinkDB

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