KEGG   PATHWAY: pleu04148
Entry
pleu04148                   Pathway                                
Name
Efferocytosis - Peromyscus leucopus (white-footed mouse)
Class
Cellular Processes; Transport and catabolism
Pathway map
pleu04148  Efferocytosis
pleu04148

Organism
Peromyscus leucopus (white-footed mouse) [GN:pleu]
Gene
114680960  Rab7a; ras-related protein Rab-7a [KO:K07897]
114681026  Atp11c; phospholipid-transporting ATPase IG isoform X1 [KO:K26934]
114681035  Nfatc3; nuclear factor of activated T-cells, cytoplasmic 3 isoform X1 [KO:K17333]
114681109  Vps39; vam6/Vps39-like protein isoform X2 [KO:K20183]
114681126  [KO:K20181]
114681138  [KO:K05116] [EC:2.7.10.1]
114681278  Cx3cr1; CX3C chemokine receptor 1 [KO:K04192]
114681738  Rab5b; ras-related protein Rab-5B [KO:K07888]
114681906  Ptpn11; LOW QUALITY PROTEIN: tyrosine-protein phosphatase non-receptor type 11 [KO:K07293] [EC:3.1.3.48]
114682062  Elmo1; LOW QUALITY PROTEIN: engulfment and cell motility protein 1 [KO:K12366]
114682227  Camk2d; calcium/calmodulin-dependent protein kinase type II subunit delta isoform X1 [KO:K04515] [EC:2.7.11.17]
114682408  Arnt; aryl hydrocarbon receptor nuclear translocator isoform X1 [KO:K09097]
114682445  S1pr1; sphingosine 1-phosphate receptor 1 [KO:K04288]
114682714  Crkl; crk-like protein [KO:K04438]
114682732  Mapk1; mitogen-activated protein kinase 1 [KO:K04371] [EC:2.7.11.24]
114682792  Rab5c; ras-related protein Rab-5C [KO:K07889]
114683432  Pla2g15; phospholipase A2 group XV isoform X1 [KO:K06129] [EC:3.1.1.5]
114683448  Abca1; phospholipid-transporting ATPase ABCA1 [KO:K05641]
114683746  Hif1a; hypoxia-inducible factor 1-alpha isoform X1 [KO:K08268]
114683769  Tmem30b; cell cycle control protein 50B [KO:K26935]
114683935  [KO:K06749]
114684076  Atp11b; probable phospholipid-transporting ATPase IF isoform X1 [KO:K26934]
114684098  Bsg; basigin isoform X1 [KO:K06535]
114684303  Xkr4; XK-related protein 4 [KO:K26811]
114684350  Cpt1c; carnitine O-palmitoyltransferase 1, brain isoform isoform X1 [KO:K19524] [EC:2.3.1.21]
114684351  Nr1h2; oxysterols receptor LXR-beta isoform X1 [KO:K08535]
114684433  Nfatc2; nuclear factor of activated T-cells, cytoplasmic 2 isoform X1 [KO:K17332]
114684665  Vps8; vacuolar protein sorting-associated protein 8 homolog isoform X1 [KO:K20178]
114684677  Sphk2; sphingosine kinase 2 [KO:K04718] [EC:2.7.1.91]
114685003  Panx1; pannexin-1 isoform X2 [KO:K03443]
114685042  [KO:K06535]
114685293  Axl; tyrosine-protein kinase receptor UFO isoform X1 [KO:K05115] [EC:2.7.10.1]
114685302  Tgfb1; transforming growth factor beta-1 proprotein [KO:K13375]
114685480  Vps41; vacuolar protein sorting-associated protein 41 homolog isoform X2 [KO:K20184]
114686672  Atp2a1; LOW QUALITY PROTEIN: sarcoplasmic/endoplasmic reticulum calcium ATPase 1 [KO:K05853] [EC:7.2.2.10]
114686767  Epo; erythropoietin [KO:K05437]
114686853  Casp1; caspase-1 [KO:K01370] [EC:3.4.22.36]
114687088  Calr; calreticulin [KO:K08057]
114688121  Map2k2; dual specificity mitogen-activated protein kinase kinase 2 [KO:K04369] [EC:2.7.12.2]
114689091  [KO:K20413]
114689256  [KO:K20413]
114689632  Pparg; peroxisome proliferator-activated receptor gamma isoform X1 [KO:K08530]
114689650  Alox5; polyunsaturated fatty acid 5-lipoxygenase [KO:K00461] [EC:1.13.11.34]
114689815  Havcr2; hepatitis A virus cellular receptor 2 [KO:K20414]
114689907  Pbx1; pre-B-cell leukemia transcription factor 1 isoform X1 [KO:K09355]
114690139  Xkr9; XK-related protein 9 isoform X1 [KO:K26814]
114690420  Pecam1; platelet endothelial cell adhesion molecule isoform X1 [KO:K06471]
114690776  Adam10; disintegrin and metalloproteinase domain-containing protein 10 [KO:K06704] [EC:3.4.24.81]
114690828  Tgfbrap1; transforming growth factor-beta receptor-associated protein 1 [KO:K20177]
114691172  Vps11; vacuolar protein sorting-associated protein 11 homolog isoform X1 [KO:K20179]
114691435  Scarf1; LOW QUALITY PROTEIN: scavenger receptor class F member 1 [KO:K24318]
114691441  Crk; adapter molecule crk isoform X1 [KO:K04438]
114691468  Megf11; LOW QUALITY PROTEIN: multiple epidermal growth factor-like domains protein 11 [KO:K24068]
114691497  Map2k1; dual specificity mitogen-activated protein kinase kinase 1 isoform X2 [KO:K04368] [EC:2.7.12.2]
114691908  Cd47; leukocyte surface antigen CD47 isoform X1 [KO:K06266]
114691963  [KO:K26935]
114692269  Ano9; anoctamin-9 isoform X1 [KO:K19503]
114692312  [KO:K05116] [EC:2.7.10.1]
114692670  Cebpb; CCAAT/enhancer-binding protein beta [KO:K10048]
114692902  Dock1; dedicator of cytokinesis protein 1 isoform X1 [KO:K13708]
114693019  Mapk12; mitogen-activated protein kinase 12 [KO:K04441] [EC:2.7.11.24]
114693020  Mapk11; mitogen-activated protein kinase 11 isoform X5 [KO:K04441] [EC:2.7.11.24]
114693032  Cpt1b; carnitine O-palmitoyltransferase 1, muscle isoform [KO:K19523] [EC:2.3.1.21]
114693072  Ano6; anoctamin-6 isoform X1 [KO:K19500]
114693249  [KO:K00460] [EC:1.13.11.33]
114693817  Casp3; caspase-3 isoform X1 [KO:K02187] [EC:3.4.22.56]
114693833  Atp8a2; phospholipid-transporting ATPase IB isoform X2 [KO:K14802] [EC:7.6.2.1]
114693978  Camk2b; calcium/calmodulin-dependent protein kinase type II subunit beta isoform X7 [KO:K04515] [EC:2.7.11.17]
114694021  Dusp8; dual specificity protein phosphatase 8 [KO:K04459] [EC:3.1.3.16 3.1.3.48]
114694084  [KO:K05853] [EC:7.2.2.10]
114694258  Pla2g6; 85/88 kDa calcium-independent phospholipase A2 isoform X1 [KO:K16343] [EC:3.1.1.4]
114694453  [KO:K06469]
114694497  Cx3cl1; fractalkine [KO:K05508]
114694545  Cpt1a; carnitine O-palmitoyltransferase 1, liver isoform [KO:K08765] [EC:2.3.1.21]
114694913  Nfatc1; nuclear factor of activated T-cells, cytoplasmic 1 isoform X1 [KO:K04446]
114695247  Epor; LOW QUALITY PROTEIN: erythropoietin receptor [KO:K05079]
114696004  Ptger2; prostaglandin E2 receptor EP2 subtype [KO:K04259]
114696775  Ptgs2; prostaglandin G/H synthase 2 [KO:K11987] [EC:1.14.99.1]
114697046  Dusp5; dual specificity protein phosphatase 5 [KO:K04459] [EC:3.1.3.16 3.1.3.48]
114697063  Casp7; caspase-7 isoform X1 [KO:K04397] [EC:3.4.22.60]
114697064  Dnmt3a; DNA (cytosine-5)-methyltransferase 3A isoform X1 [KO:K17398] [EC:2.1.1.37]
114697176  Slc66a1; lysosomal amino acid transporter 1 homolog [KO:K23678]
114697210  C1qa; complement C1q subcomponent subunit A [KO:K03986]
114697211  C1qc; complement C1q subcomponent subunit C [KO:K03988]
114697212  C1qb; complement C1q subcomponent subunit B [KO:K03987]
114697342  Ptger4; prostaglandin E2 receptor EP4 subtype [KO:K04261]
114697772  Arg2; arginase-2, mitochondrial [KO:K01476] [EC:3.5.3.1]
114698039  Il10; interleukin-10 [KO:K05443]
114698053  Mapkapk2; MAP kinase-activated protein kinase 2 [KO:K04443] [EC:2.7.11.1]
114698061  Rab7b; ras-related protein Rab-7b isoform X2 [KO:K07898]
114698623  Arg1; arginase-1 [KO:K01476] [EC:3.5.3.1]
114698734  P2ry6; P2Y purinoceptor 6 [KO:K04272]
114698735  P2ry2; P2Y purinoceptor 2 [KO:K04269]
114698847  Odc1; ornithine decarboxylase [KO:K01581] [EC:4.1.1.17]
114698857  Adam17; disintegrin and metalloproteinase domain-containing protein 17 isoform X1 [KO:K06059] [EC:3.4.24.86]
114699481  Sirpa; tyrosine-protein phosphatase non-receptor type substrate 1 isoform X1 [KO:K06551]
114699493  Vps16; vacuolar protein sorting-associated protein 16 homolog [KO:K20180]
114699685  Nr1h3; oxysterols receptor LXR-alpha isoform X2 [KO:K08536]
114699879  Mfge8; lactadherin isoform X1 [KO:K17253]
114700041  Pros1; LOW QUALITY PROTEIN: vitamin K-dependent protein S [KO:K03908]
114700207  Camk2g; calcium/calmodulin-dependent protein kinase type II subunit gamma isoform X1 [KO:K04515] [EC:2.7.11.17]
114700270  Tmem30a; cell cycle control protein 50A [KO:K26935]
114700521  Ano5; anoctamin-5 [KO:K19480]
114700629  Ano4; anoctamin-4 isoform X1 [KO:K19499]
114700641  Stab2; stabilin-2 isoform X1 [KO:K19013]
114700673  Rab17; ras-related protein Rab-17 [KO:K07909]
114701092  [KO:K00411] [EC:7.1.1.8]
114701128  Sirt1; NAD-dependent protein deacetylase sirtuin-1 [KO:K11411] [EC:2.3.1.286]
114701237  Gas6; growth arrest-specific protein 6 [KO:K05464]
114701252  Atp11a; probable phospholipid-transporting ATPase IH isoform X1 [KO:K26934]
114701855  [KO:K00411] [EC:7.1.1.8]
114701965  P2ry12; P2Y purinoceptor 12 [KO:K04298]
114702037  Atp8a1; phospholipid-transporting ATPase IA isoform X1 [KO:K14802] [EC:7.6.2.1]
114702099  Ano3; anoctamin-3 isoform X1 [KO:K19498]
114702284  Itgb3; integrin beta-3 [KO:K06493]
114702794  Rxra; retinoic acid receptor RXR-alpha [KO:K08524]
114703097  Gpr132; probable G-protein coupled receptor 132 isoform X3 [KO:K08426]
114703357  Xkr6; LOW QUALITY PROTEIN: XK-related protein 6 [KO:K26811]
114703598  Itgav; integrin alpha-V isoform X1 [KO:K06487]
114704109  [KO:K06551]
114704110  [KO:K06551]
114704332  Mapk3; mitogen-activated protein kinase 3 [KO:K04371] [EC:2.7.11.24]
114704537  Vps33a; LOW QUALITY PROTEIN: vacuolar protein sorting-associated protein 33A [KO:K20182]
114704560  Atp2a2; sarcoplasmic/endoplasmic reticulum calcium ATPase 2 [KO:K05853] [EC:7.2.2.10]
114704626  Vps18; LOW QUALITY PROTEIN: vacuolar protein sorting-associated protein 18 homolog [KO:K20181]
114704659  Ptk2; focal adhesion kinase 1 isoform X1 [KO:K05725] [EC:2.7.10.2]
114704667  Adgrb1; LOW QUALITY PROTEIN: adhesion G protein-coupled receptor B1 [KO:K04596]
114704702  Rab14; ras-related protein Rab-14 [KO:K07881]
114704792  Lrp1; prolow-density lipoprotein receptor-related protein 1 [KO:K04550]
114704849  Itgb5; LOW QUALITY PROTEIN: integrin beta-5 [KO:K06588]
114704945  Slc2a1; solute carrier family 2, facilitated glucose transporter member 1 isoform X1 [KO:K07299]
114705042  [KO:K06469]
114705057  Creb1; cyclic AMP-responsive element-binding protein 1 isoform X1 [KO:K05870]
114705262  Gulp1; PTB domain-containing engulfment adapter protein 1 isoform X1 [KO:K23285]
114705545  Xkr7; XK-related protein 7 [KO:K26811]
114705638  [KO:K01581] [EC:4.1.1.17]
114705813  Ager; advanced glycosylation end product-specific receptor isoform X1 [KO:K19722]
114705915  Thbs1; LOW QUALITY PROTEIN: thrombospondin-1 [KO:K16857]
114705954  Xkr8; XK-related protein 8 isoform X1 [KO:K26813]
114706127  Ppard; peroxisome proliferator-activated receptor delta [KO:K04504]
114706162  Mapk13; mitogen-activated protein kinase 13 [KO:K04441] [EC:2.7.11.24]
114706165  Mapk14; mitogen-activated protein kinase 14 isoform X1 [KO:K04441] [EC:2.7.11.24]
114706333  Atp2a3; LOW QUALITY PROTEIN: sarcoplasmic/endoplasmic reticulum calcium ATPase 3 [KO:K05853] [EC:7.2.2.10]
114706371  [KO:K26936]
114706385  [KO:K20413]
114707026  Sphk1; sphingosine kinase 1 isoform X1 [KO:K04718] [EC:2.7.1.91]
114707248  Slc16a1; LOW QUALITY PROTEIN: monocarboxylate transporter 1 [KO:K08179]
114707396  Camk2a; LOW QUALITY PROTEIN: calcium/calmodulin-dependent protein kinase type II subunit alpha [KO:K04515] [EC:2.7.11.17]
114707466  Rab5a; ras-related protein Rab-5A [KO:K07887]
114707535  Rac1; ras-related C3 botulinum toxin substrate 1 isoform X1 [KO:K04392]
114707623  [KO:K08057]
114707785  Ano7; anoctamin-7 isoform X1 [KO:K19501]
114708171  Stab1; stabilin-1 [KO:K19020]
114708224  Cd36; platelet glycoprotein 4 [KO:K06259]
114708378  Megf10; multiple epidermal growth factor-like domains protein 10 [KO:K24068]
114708726  Nfatc4; nuclear factor of activated T-cells, cytoplasmic 4 [KO:K17334]
114708811  Ptpn6; tyrosine-protein phosphatase non-receptor type 6 isoform X1 [KO:K05697] [EC:3.1.3.48]
114709081  Dusp2; dual specificity protein phosphatase 2 [KO:K04459] [EC:3.1.3.16 3.1.3.48]
114709099  Bcar1; breast cancer anti-estrogen resistance protein 1 isoform X1 [KO:K05726]
114709506  Mertk; tyrosine-protein kinase Mer [KO:K05117] [EC:2.7.10.1]
114710367  Dusp16; dual specificity protein phosphatase 16 [KO:K04459] [EC:3.1.3.16 3.1.3.48]
114710385  Jak2; tyrosine-protein kinase JAK2 [KO:K04447] [EC:2.7.10.2]
114710523  [KO:K04371] [EC:2.7.11.24]
114710667  Cd24; signal transducer CD24 [KO:K06469]
114710975  Dusp7; dual specificity protein phosphatase 7 [KO:K04459] [EC:3.1.3.16 3.1.3.48]
119088785  [KO:K06266]
119088838  [KO:K04438]
Compound
C00002  ATP
C00003  NAD+
C00019  S-Adenosyl-L-methionine
C00031  D-Glucose
C00062  L-Arginine
C00073  L-Methionine
C00075  UTP
C00077  L-Ornithine
C00134  Putrescine
C00162  Fatty acid
C00186  (S)-Lactate
C00187  Cholesterol
C00584  Prostaglandin E2
C02530  Cholesterol ester
C02737  Phosphatidylserine
C04230  1-Acyl-sn-glycero-3-phosphocholine
C06124  Sphingosine 1-phosphate
C06314  Lipoxin A4
C15519  25-Hydroxycholesterol
C15610  Cholest-5-ene-3beta,26-diol
C18178  Resolvin D1
Reference
PMID:31822793
  Authors
Doran AC, Yurdagul A Jr, Tabas I
  Title
Efferocytosis in health and disease.
  Journal
Nat Rev Immunol 20:254-267 (2020)
DOI:10.1038/s41577-019-0240-6
Reference
PMID:36028471
  Authors
Zhang J, Ding W, Zhao M, Liu J, Xu Y, Wan J, Wang M
  Title
Mechanisms of efferocytosis in determining inflammation resolution: Therapeutic potential and the association with cardiovascular disease.
  Journal
Br J Pharmacol 179:5151-5171 (2022)
DOI:10.1111/bph.15939
Reference
PMID:30165442
  Authors
Kawano M, Nagata S
  Title
Efferocytosis and autoimmune disease.
  Journal
Int Immunol 30:551-558 (2018)
DOI:10.1093/intimm/dxy055
Reference
PMID:35650427
  Authors
Mehrotra P, Ravichandran KS
  Title
Drugging the efferocytosis process: concepts and opportunities.
  Journal
Nat Rev Drug Discov 21:601-620 (2022)
DOI:10.1038/s41573-022-00470-y
Reference
PMID:28496201
  Authors
Park SY, Kim IS
  Title
Engulfment signals and the phagocytic machinery for apoptotic cell clearance.
  Journal
Exp Mol Med 49:e331 (2017)
DOI:10.1038/emm.2017.52
Reference
PMID:28137963
  Authors
Kojima Y, Weissman IL, Leeper NJ
  Title
The Role of Efferocytosis in Atherosclerosis.
  Journal
Circulation 135:476-489 (2017)
DOI:10.1161/CIRCULATIONAHA.116.025684
Related
pathway
pleu00010  Glycolysis / Gluconeogenesis
pleu04140  Autophagy - animal
pleu04145  Phagosome
KO pathway
ko04148   

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