Entry Name JAK-STAT signaling pathway - Peromyscus leucopus (white-footed mouse)
Description The Janus kinase/signal transducers and activators of transcription (JAK/STAT) pathway is one of a handful of pleiotropic cascades used to transduce a multitude of signals for development and homeostasis in animals, from humans to flies. In mammals, the JAK/STAT pathway is the principal signaling mechanism for a wide array of cytokines and growth factors. Following the binding of cytokines to their cognate receptor, STATs are activated by members of the JAK family of tyrosine kinases. Once activated, they dimerize and translocate to the nucleus and modulate the expression of target genes. In addition to the activation of STATs, JAKs mediate the recruitment of other molecules such as the MAP kinases, PI3 kinase etc. These molecules process downstream signals via the Ras-Raf-MAP kinase and PI3 kinase pathways which results in the activation of additional transcription factors.
Class Environmental Information Processing; Signal transductionBRITE hierarchy
Pathway map Other DBs Organism Peromyscus leucopus (white-footed mouse) [GN:
pleu ]
Gene 114680925 Pias3; E3 SUMO-protein ligase PIAS3 isoform X1 [KO:K16064 ] [EC:2.3.2.-]
114681747 Stat2; signal transducer and activator of transcription 2 [KO:K11221 ]
114682383 Mcl1; LOW QUALITY PROTEIN: induced myeloid leukemia cell differentiation protein Mcl-1 [KO:K02539 ]
114682786 Stat3; signal transducer and activator of transcription 3 isoform X1 [KO:K04692 ]
114682811 Stat5a; signal transducer and activator of transcription 5A [KO:K11223 ]
114684032 Pik3cd; LOW QUALITY PROTEIN: phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform [KO:K00922 ] [EC:2.7.1.153 ]
114684059 Il13ra2; LOW QUALITY PROTEIN: interleukin-13 receptor subunit alpha-2 [KO:K05077 ]
114684168 Il27ra; LOW QUALITY PROTEIN: interleukin-27 receptor subunit alpha [KO:K19598 ]
114685985 Clcf1; cardiotrophin-like cytokine factor 1 isoform X3 [KO:K05421 ]
114686994 Il20ra; interleukin-20 receptor subunit alpha isoform X2 [KO:K05136 ]
114688966 Pik3r2; phosphatidylinositol 3-kinase regulatory subunit beta isoform X1 [KO:K02649 ]
114691198 Il10ra; interleukin-10 receptor subunit alpha isoform X1 [KO:K05134 ]
114691625 Pias1; E3 SUMO-protein ligase PIAS1 isoform X1 [KO:K04706 ] [EC:2.3.2.-]
114692223 Il4r; interleukin-4 receptor subunit alpha isoform X1 [KO:K05071 ]
114693559 Pik3cb; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform [KO:K00922 ] [EC:2.7.1.153 ]
114693935 Stam; signal transducing adapter molecule 1 isoform X1 [KO:K04705 ]
114694223 Csf2rb; cytokine receptor common subunit beta isoform X3 [KO:K04738 ]
114694276 Pdgfb; platelet-derived growth factor subunit B isoform X1 [KO:K17386 ]
114694353 Il2rb; interleukin-2 receptor subunit beta isoform X2 [KO:K05069 ]
114694887 Pias2; E3 SUMO-protein ligase PIAS2 isoform X1 [KO:K16063 ] [EC:2.3.2.-]
114695335 Pik3ca; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform [KO:K00922 ] [EC:2.7.1.153 ]
114697151 Il22ra1; interleukin-22 receptor subunit alpha-1 isoform X1 [KO:K05138 ]
114697347 Osmr; oncostatin-M-specific receptor subunit beta isoform X1 [KO:K05057 ]
114698437 Ifnar2; LOW QUALITY PROTEIN: interferon alpha/beta receptor 2 [KO:K05131 ]
114700391 Csf2; granulocyte-macrophage colony-stimulating factor [KO:K05427 ]
114700924 Il12rb2; LOW QUALITY PROTEIN: interleukin-12 receptor subunit beta-2 [KO:K05064 ]
114703234 Cntfr; LOW QUALITY PROTEIN: ciliary neurotrophic factor receptor subunit alpha [KO:K05059 ]
114703579 Il6st; LOW QUALITY PROTEIN: interleukin-6 receptor subunit beta [KO:K05060 ]
114703850 Pik3r1; phosphatidylinositol 3-kinase regulatory subunit alpha isoform X1 [KO:K02649 ]
114704288 Csf3r; granulocyte colony-stimulating factor receptor isoform X2 [KO:K05061 ]
114704789 Stat6; signal transducer and activator of transcription 6 isoform X1 [KO:K11225 ]
114705035 Stat1; signal transducer and activator of transcription 1-alpha/beta [KO:K11220 ]
114705158 Socs6; LOW QUALITY PROTEIN: suppressor of cytokine signaling 6 [KO:K04699 ]
114705439 Stat4; signal transducer and activator of transcription 4 isoform X1 [KO:K11222 ]
114706924 Pik3r3; phosphatidylinositol 3-kinase regulatory subunit gamma isoform X1 [KO:K02649 ]
114707228 Fhl1; four and a half LIM domains protein 1 isoform X1 [KO:K14365 ]
114707920 Il6r; LOW QUALITY PROTEIN: interleukin-6 receptor subunit alpha [KO:K05055 ]
114708198 Il15ra; interleukin-15 receptor subunit alpha isoform X1 [KO:K05074 ]
114709145 Socs5; LOW QUALITY PROTEIN: suppressor of cytokine signaling 5 [KO:K04698 ]
Reference Authors Harrison DA
Title The Jak/STAT pathway.
Journal Reference Authors Kiu H, Nicholson SE
Title Biology and significance of the JAK/STAT signalling pathways.
Journal Reference Authors Hervas-Stubbs S, Perez-Gracia JL, Rouzaut A, Sanmamed MF, Le Bon A, Melero I
Title Direct effects of type I interferons on cells of the immune system.
Journal Reference Authors Fish EN, Platanias LC
Title Interferon receptor signaling in malignancy: a network of cellular pathways defining biological outcomes.
Journal Reference Authors Ivanenkov YA, Balakin KV, Lavrovsky Y
Title Small molecule inhibitors of NF-kB and JAK/STAT signal transduction pathways as promising anti-inflammatory therapeutics.
Journal Reference Authors O'Shea JJ, Schwartz DM, Villarino AV, Gadina M, McInnes IB, Laurence A
Title The JAK-STAT pathway: impact on human disease and therapeutic intervention.
Journal Reference Authors Zoranovic T, Grmai L, Bach EA
Title Regulation of proliferation, cell competition, and cellular growth by the Drosophila JAK-STAT pathway.
Journal Reference Authors Ungureanu D, Silvennoinen O
Title SLIM trims STATs: ubiquitin E3 ligases provide insights for specificity in the regulation of cytokine signaling.
Journal Reference Authors Richard AJ, Stephens JM
Title The role of JAK-STAT signaling in adipose tissue function.
Journal Reference Authors Sun Y, Lehmbecker A, Kalkuhl A, Deschl U, Sun W, Rohn K, Tzvetanova ID, Nave KA, Baumgartner W, Ulrich R
Title STAT3 represents a molecular switch possibly inducing astroglial instead of oligodendroglial differentiation of oligodendroglial progenitor cells in Theiler's murine encephalomyelitis.
Journal Reference Authors Hirano T, Ishihara K, Hibi M
Title Roles of STAT3 in mediating the cell growth, differentiation and survival signals relayed through the IL-6 family of cytokine receptors.
Journal Reference Authors Rane SG, Reddy EP
Title Janus kinases: components of multiple signaling pathways.
Journal Reference Authors Heim MH
Title The Jak-STAT pathway: specific signal transduction from the cell membrane to the nucleus.
Journal Reference Authors Morris R, Kershaw NJ, Babon JJ
Title The molecular details of cytokine signaling via the JAK/STAT pathway.
Journal Reference Authors Tzeng HT, Chyuan IT, Lai JH
Title Targeting the JAK-STAT pathway in autoimmune diseases and cancers: A focus on molecular mechanisms and therapeutic potential.
Journal Reference Authors Salas A, Hernandez-Rocha C, Duijvestein M, Faubion W, McGovern D, Vermeire S, Vetrano S, Vande Casteele N
Title JAK-STAT pathway targeting for the treatment of inflammatory bowel disease.
Journal Related pleu04060 Cytokine-cytokine receptor interaction
KO pathway
