KEGG   PATHWAY: pleu05415
Entry
pleu05415                   Pathway                                
Name
Diabetic cardiomyopathy - Peromyscus leucopus (white-footed mouse)
Description
Diabetic cardiomyopathy has been defined as left ventricular dysfunction that occurs among patients with diabetes mellitus independent of a recognized cause such as coronary artery disease or hypertension. The pathogenesis of diabetic cardiomyopathy broadly involves hyperglycemia, increased circulating fatty acids, and insulin resistance contributing to reactive oxygen species (ROS) generation, mitochondrial dysfunction, impaired calcium metabolism, Renin-Angiotensin System (RAS) activation, and altered substrate metabolism. These effects result in cardiac fibrosis, hypertrophy, cardiomyocyte death, contractile dysfunction, endothelial cell damage and eventually heart failure. In the process of cardiac fibrosis, cardiac fibroblasts are the final effector cell.
Class
Human Diseases; Cardiovascular disease
Pathway map
pleu05415  Diabetic cardiomyopathy
pleu05415

Disease
H02498  Diabetic cardiomyopathy
Organism
Peromyscus leucopus (white-footed mouse) [GN:pleu]
Gene
114680673  Gfpt1; glutamine--fructose-6-phosphate aminotransferase [isomerizing] 1 isoform X1 [KO:K00820] [EC:2.6.1.16]
114680674  Plcb3; LOW QUALITY PROTEIN: 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-3 [KO:K05858] [EC:3.1.4.11]
114680703  [KO:K02273]
114680730  Pdhb; pyruvate dehydrogenase E1 component subunit beta, mitochondrial [KO:K00162] [EC:1.2.4.1]
114680800  Ndufb10; NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 10 [KO:K03966]
114681169  Ndufs5; NADH dehydrogenase [ubiquinone] iron-sulfur protein 5 [KO:K03938]
114681332  [KO:K02266]
114681496  Gfpt2; glutamine--fructose-6-phosphate aminotransferase [isomerizing] 2 [KO:K00820] [EC:2.6.1.16]
114681520  Mapk9; mitogen-activated protein kinase 9 isoform X1 [KO:K04440] [EC:2.7.11.24]
114681524  Akt2; RAC-beta serine/threonine-protein kinase isoform X1 [KO:K04456] [EC:2.7.11.1]
114681638  [KO:K02270]
114681644  [KO:K02267]
114681741  [KO:K00237]
114681917  Vdac1; voltage-dependent anion-selective channel protein 1 [KO:K05862]
114681926  [KO:K00418]
114682022  Atp5f1e; ATP synthase subunit epsilon, mitochondrial [KO:K02135]
114682099  Rela; transcription factor p65 [KO:K04735]
114682227  Camk2d; calcium/calmodulin-dependent protein kinase type II subunit delta isoform X1 [KO:K04515] [EC:2.7.11.17]
114683045  [KO:K02135]
114683184  Insr; insulin receptor isoform X3 [KO:K04527] [EC:2.7.10.1]
114683205  Nfkb1; nuclear factor NF-kappa-B p105 subunit [KO:K02580]
114683779  [KO:K00161] [EC:1.2.4.1]
114683953  [KO:K06269] [EC:3.1.3.16]
114684032  Pik3cd; LOW QUALITY PROTEIN: phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform [KO:K00922] [EC:2.7.1.153]
114684114  Ndufs7; NADH dehydrogenase [ubiquinone] iron-sulfur protein 7, mitochondrial [KO:K03940] [EC:7.1.1.2]
114684126  Atp5f1d; ATP synthase subunit delta, mitochondrial [KO:K02134]
114684630  Gys1; glycogen [starch] synthase, muscle [KO:K00693] [EC:2.4.1.11]
114685054  Ryr2; LOW QUALITY PROTEIN: ryanodine receptor 2 [KO:K04962]
114685302  Tgfb1; transforming growth factor beta-1 proprotein [KO:K13375]
114685317  Ndufa7; NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 7 [KO:K03951]
114685415  Sdhc; succinate dehydrogenase cytochrome b560 subunit, mitochondrial [KO:K00236]
114685431  Ndufs2; NADH dehydrogenase [ubiquinone] iron-sulfur protein 2, mitochondrial [KO:K03935] [EC:7.1.1.2]
114685872  [KO:K03967]
114685987  Ppp1ca; serine/threonine-protein phosphatase PP1-alpha catalytic subunit [KO:K06269] [EC:3.1.3.16]
114686251  Agtr1; type-1 angiotensin II receptor [KO:K04166]
114686525  [KO:K00420]
114686672  Atp2a1; LOW QUALITY PROTEIN: sarcoplasmic/endoplasmic reticulum calcium ATPase 1 [KO:K05853] [EC:7.2.2.10]
114686683  Ndufa13; NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 13 [KO:K11353]
114686928  Atp5f1b; ATP synthase subunit beta, mitochondrial [KO:K02133] [EC:7.1.2.2]
114687523  Prkcg; protein kinase C gamma type [KO:K19663] [EC:2.7.11.13]
114687713  [KO:K02267]
114688226  Ndufb7; NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 7 [KO:K03963]
114688434  Ndufa3; NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 3 [KO:K03947]
114688857  Ndufa11; NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 11 [KO:K03956]
114688889  [KO:K06236]
114688966  Pik3r2; phosphatidylinositol 3-kinase regulatory subunit beta isoform X1 [KO:K02649]
114689156  Tnni3; troponin I, cardiac muscle [KO:K12044]
114689804  [KO:K00417]
114689841  [KO:K02271]
114689931  Mpc2; mitochondrial pyruvate carrier 2 [KO:K22139]
114690192  Tbc1d4; TBC1 domain family member 4 isoform X1 [KO:K17902]
114690246  Sdhd; succinate dehydrogenase [ubiquinone] cytochrome b small subunit, mitochondrial [KO:K00237]
114690344  [KO:K02264]
114690399  [KO:K01283] [EC:3.4.15.1]
114690439  Prkca; protein kinase C alpha type [KO:K02677] [EC:2.7.11.13]
114690491  [KO:K01283] [EC:3.4.15.1]
114690631  Parp1; poly [ADP-ribose] polymerase 1 [KO:K24070]
114690660  Akt3; RAC-gamma serine/threonine-protein kinase isoform X1 [KO:K04456] [EC:2.7.11.1]
114690723  [KO:K02271]
114690777  [KO:K02265]
114690920  [KO:K04674] [EC:2.7.11.30]
114690973  [KO:K02264]
114691352  Mpc1; mitochondrial pyruvate carrier 1 [KO:K22138]
114691539  Smad3; mothers against decapentaplegic homolog 3 [KO:K23605]
114691745  [KO:K04674] [EC:2.7.11.30]
114691777  Mapk10; mitogen-activated protein kinase 10 isoform X1 [KO:K04440] [EC:2.7.11.24]
114691928  [KO:K05862]
114692176  [KO:K00415]
114692200  Ndufab1; acyl carrier protein, mitochondrial [KO:K03955]
114692203  Prkcb; protein kinase C beta type isoform X1 [KO:K19662] [EC:2.7.11.13]
114692635  Mmp9; matrix metalloproteinase-9 [KO:K01403] [EC:3.4.24.35]
114692897  Col1a1; collagen alpha-1(I) chain isoform X1 [KO:K06236]
114692903  Pdk2; pyruvate dehydrogenase kinase, isozyme 2 isoform X1 [KO:K00898] [EC:2.7.11.2]
114692923  Atp5mc1; ATP synthase F(0) complex subunit C1, mitochondrial [KO:K02128]
114693019  Mapk12; mitogen-activated protein kinase 12 [KO:K04441] [EC:2.7.11.24]
114693020  Mapk11; mitogen-activated protein kinase 11 isoform X5 [KO:K04441] [EC:2.7.11.24]
114693032  Cpt1b; carnitine O-palmitoyltransferase 1, muscle isoform [KO:K19523] [EC:2.3.1.21]
114693201  Slc2a4; solute carrier family 2, facilitated glucose transporter member 4 [KO:K07191]
114693444  Col1a2; LOW QUALITY PROTEIN: collagen alpha-2(I) chain [KO:K06236]
114693453  Pdk4; pyruvate dehydrogenase kinase, isozyme 4 [KO:K00898] [EC:2.7.11.2]
114693469  [KO:K02273]
114693559  Pik3cb; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform [KO:K00922] [EC:2.7.1.153]
114693708  Ncf1; neutrophil cytosol factor 1 [KO:K08011]
114693920  [KO:K02266]
114693978  Camk2b; calcium/calmodulin-dependent protein kinase type II subunit beta isoform X7 [KO:K04515] [EC:2.7.11.17]
114694043  Ctsd; cathepsin D [KO:K01379] [EC:3.4.23.5]
114694084  [KO:K05853] [EC:7.2.2.10]
114694100  [KO:K00419]
114694169  [KO:K00413]
114694222  Ncf4; neutrophil cytosol factor 4 [KO:K08012]
114694231  Rac2; ras-related C3 botulinum toxin substrate 2 [KO:K07860]
114694322  Ndufa6; NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 6 [KO:K03950]
114694445  [KO:K05863]
114694533  Mmp2; LOW QUALITY PROTEIN: 72 kDa type IV collagenase [KO:K01398] [EC:3.4.24.24]
114694672  Ndufs8; NADH dehydrogenase [ubiquinone] iron-sulfur protein 8, mitochondrial [KO:K03941] [EC:7.1.1.2]
114694673  [KO:K02268]
114694751  Ndufv1; NADH dehydrogenase [ubiquinone] flavoprotein 1, mitochondrial [KO:K03942] [EC:7.1.1.2]
114694791  [KO:K02271]
114694811  Ndufb9; NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 9 [KO:K03965]
114694883  Smad2; mothers against decapentaplegic homolog 2 [KO:K04500]
114694895  Atp5f1a; ATP synthase subunit alpha, mitochondrial [KO:K02132]
114695174  Ins; insulin [KO:K04526]
114695335  Pik3ca; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform [KO:K00922] [EC:2.7.1.153]
114695345  Ndufb5; NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 5, mitochondrial [KO:K03961]
114695599  Ndufa5; NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 5 [KO:K03949]
114695795  Pdha1; pyruvate dehydrogenase E1 component subunit alpha, somatic form, mitochondrial [KO:K00161] [EC:1.2.4.1]
114695853  Ndufc1; NADH dehydrogenase [ubiquinone] 1 subunit C1, mitochondrial [KO:K03967]
114696086  Sdha; succinate dehydrogenase [ubiquinone] flavoprotein subunit, mitochondrial [KO:K00234] [EC:1.3.5.1]
114696107  Ndufs6; LOW QUALITY PROTEIN: NADH dehydrogenase [ubiquinone] iron-sulfur protein 6, mitochondrial [KO:K03939]
114696284  Ppp1cb; serine/threonine-protein phosphatase PP1-beta catalytic subunit [KO:K06269] [EC:3.1.3.16]
114696316  Ndufv2; NADH dehydrogenase [ubiquinone] flavoprotein 2, mitochondrial [KO:K03943] [EC:7.1.1.2]
114696438  Irs1; insulin receptor substrate 1 [KO:K16172]
114696614  Atp5mc2; ATP synthase F(0) complex subunit C2, mitochondrial [KO:K02128]
114696625  Sp1; transcription factor Sp1 isoform X1 [KO:K04684]
114697038  [KO:K00417]
114697622  [KO:K00134] [EC:1.2.1.12]
114697625  Mpc1l; mitochondrial pyruvate carrier 1-like protein [KO:K22138]
114697686  Atp5pf; ATP synthase-coupling factor 6, mitochondrial [KO:K02131]
114697904  Tgfb3; transforming growth factor beta-3 proprotein [KO:K13377]
114698044  Ren; renin [KO:K01380] [EC:3.4.23.15]
114698210  Tgfb2; transforming growth factor beta-2 proprotein isoform X1 [KO:K13376]
114698423  Atp5po; ATP synthase subunit O, mitochondrial [KO:K02137]
114698496  Gsr; LOW QUALITY PROTEIN: glutathione reductase, mitochondrial [KO:K00383] [EC:1.8.1.7]
114698667  Ndufc2; NADH dehydrogenase [ubiquinone] 1 subunit C2 [KO:K03968]
114699201  Ppara; peroxisome proliferator-activated receptor alpha [KO:K07294]
114699348  Mapk8; mitogen-activated protein kinase 8 isoform X1 [KO:K04440] [EC:2.7.11.24]
114699672  Ndufs3; NADH dehydrogenase [ubiquinone] iron-sulfur protein 3, mitochondrial [KO:K03936] [EC:7.1.1.2]
114699830  [KO:K03937]
114700088  Nos3; nitric oxide synthase, endothelial [KO:K13242] [EC:1.14.13.39]
114700207  Camk2g; calcium/calmodulin-dependent protein kinase type II subunit gamma isoform X1 [KO:K04515] [EC:2.7.11.17]
114700220  Vdac2; voltage-dependent anion-selective channel protein 2 [KO:K15040]
114700271  [KO:K02270]
114700288  Gys2; glycogen [starch] synthase, liver [KO:K00693] [EC:2.4.1.11]
114700572  Ndufa12; NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 12 [KO:K11352]
114700676  Ndufa10; LOW QUALITY PROTEIN: NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 10, mitochondrial [KO:K03954]
114700826  Atp5mc3; ATP synthase F(0) complex subunit C3, mitochondrial [KO:K02128]
114700886  Sdhb; succinate dehydrogenase [ubiquinone] iron-sulfur subunit, mitochondrial [KO:K00235] [EC:1.3.5.1]
114700949  [KO:K02263]
114700968  [KO:K08009]
114701075  [KO:K04166]
114701092  [KO:K00411] [EC:7.1.1.8]
114701179  Slc25a4; ADP/ATP translocase 1 [KO:K05863]
114701319  [KO:K21421] [EC:1.-.-.-]
114701404  [KO:K22138]
114701446  Ndufa9; NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 9, mitochondrial [KO:K03953]
114701479  Gsk3b; glycogen synthase kinase-3 beta isoform X1 [KO:K03083] [EC:2.7.11.26]
114701507  [KO:K02128]
114701563  Pdk3; pyruvate dehydrogenase kinase, isozyme 3 isoform X1 [KO:K00898] [EC:2.7.11.2]
114701855  [KO:K00411] [EC:7.1.1.8]
114701979  [KO:K00417]
114702344  Tgfbr1; TGF-beta receptor type-1 isoform X1 [KO:K04674] [EC:2.7.11.30]
114702631  [KO:K03945]
114702725  Ptpa; serine/threonine-protein phosphatase 2A activator isoform X1 [KO:K17605]
114703046  Akt1; RAC-alpha serine/threonine-protein kinase [KO:K04456] [EC:2.7.11.1]
114703266  Ndufb6; NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 6 [KO:K03962]
114703635  [KO:K02268]
114703666  Plcb4; 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-4 isoform X2 [KO:K05858] [EC:3.1.4.11]
114703672  Plcb1; 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-1 isoform X1 [KO:K05858] [EC:3.1.4.11]
114703694  [KO:K03944]
114703705  Ndufs4; NADH dehydrogenase [ubiquinone] iron-sulfur protein 4, mitochondrial isoform X1 [KO:K03937]
114703831  Ndufb11; NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 11, mitochondrial [KO:K11351]
114703850  Pik3r1; phosphatidylinositol 3-kinase regulatory subunit alpha isoform X1 [KO:K02649]
114703999  Ndufv3; NADH dehydrogenase [ubiquinone] flavoprotein 3, mitochondrial [KO:K03944]
114704190  [KO:K02268]
114704407  [KO:K02266]
114704425  [KO:K03957]
114704485  Ndufb3; NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 3 [KO:K03959]
114704560  Atp2a2; sarcoplasmic/endoplasmic reticulum calcium ATPase 2 [KO:K05853] [EC:7.2.2.10]
114704570  Ppp1cc; serine/threonine-protein phosphatase PP1-gamma catalytic subunit isoform X1 [KO:K06269] [EC:3.1.3.16]
114704715  Ndufa8; NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 8 [KO:K03952]
114704795  Ndufa4l2; NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 4-like 2 [KO:K03948]
114704883  [KO:K02271]
114704945  Slc2a1; solute carrier family 2, facilitated glucose transporter member 1 isoform X1 [KO:K07299]
114704977  Tgfbr2; TGF-beta receptor type-2 isoform X1 [KO:K04388] [EC:2.7.11.30]
114705083  Ndufa2; NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 2 [KO:K03946]
114705194  [KO:K00414]
114705256  Col3a1; collagen alpha-1(III) chain [KO:K19720]
114705416  Slc25a5; ADP/ATP translocase 2 [KO:K05863]
114705437  Ndufa1; NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 1 [KO:K03945]
114705570  [KO:K02263]
114705743  Vdac3; voltage-dependent anion-selective channel protein 3 isoform X1 [KO:K15041]
114705813  Ager; advanced glycosylation end product-specific receptor isoform X1 [KO:K19722]
114705921  Plcb2; 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-2 [KO:K05858] [EC:3.1.4.11]
114705971  [KO:K00417]
114706041  Ndufb1; NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 1 [KO:K03957]
114706046  [KO:K02273]
114706162  Mapk13; mitogen-activated protein kinase 13 [KO:K04441] [EC:2.7.11.24]
114706165  Mapk14; mitogen-activated protein kinase 14 isoform X1 [KO:K04441] [EC:2.7.11.24]
114706174  G6pd; glucose-6-phosphate 1-dehydrogenase isoform X5 [KO:K00036] [EC:1.1.1.49 1.1.1.363]
114706193  Cpt2; carnitine O-palmitoyltransferase 2, mitochondrial [KO:K08766] [EC:2.3.1.21]
114706333  Atp2a3; LOW QUALITY PROTEIN: sarcoplasmic/endoplasmic reticulum calcium ATPase 3 [KO:K05853] [EC:7.2.2.10]
114706832  Ndufb2; NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 2, mitochondrial [KO:K03958]
114706860  [KO:K00416]
114706924  Pik3r3; phosphatidylinositol 3-kinase regulatory subunit gamma isoform X1 [KO:K02649]
114707050  Atp5pd; ATP synthase subunit d, mitochondrial [KO:K02138]
114707150  Agt; angiotensinogen [KO:K09821]
114707249  Atp5pb; ATP synthase F(0) complex subunit B1, mitochondrial [KO:K02127]
114707396  Camk2a; LOW QUALITY PROTEIN: calcium/calmodulin-dependent protein kinase type II subunit alpha [KO:K04515] [EC:2.7.11.17]
114707535  Rac1; ras-related C3 botulinum toxin substrate 1 isoform X1 [KO:K04392]
114707771  [KO:K02127]
114708122  Ndufb8; NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 8, mitochondrial [KO:K03964]
114708186  Prkcd; protein kinase C delta type isoform X1 [KO:K06068] [EC:2.7.11.13]
114708203  Ndufs1; NADH-ubiquinone oxidoreductase 75 kDa subunit, mitochondrial [KO:K03934] [EC:7.1.1.2]
114708224  Cd36; platelet glycoprotein 4 [KO:K06259]
114708277  Prkcz; LOW QUALITY PROTEIN: protein kinase C zeta type [KO:K18952] [EC:2.7.11.13]
114708306  Atp5f1c; ATP synthase subunit gamma, mitochondrial isoform X1 [KO:K02136]
114708408  [KO:K02272]
114708599  [KO:K03941] [EC:7.1.1.2]
114708619  [KO:K02268]
114708716  [KO:K01329] [EC:3.4.21.39]
114708743  [KO:K01329] [EC:3.4.21.39]
114708781  Gapdh; glyceraldehyde-3-phosphate dehydrogenase [KO:K00134] [EC:1.2.1.12]
114708910  [KO:K02270]
114709380  [KO:K00134] [EC:1.2.1.12]
114709626  Ppif; peptidyl-prolyl cis-trans isomerase F, mitochondrial isoform X1 [KO:K09565] [EC:5.2.1.8]
114709670  Mtor; LOW QUALITY PROTEIN: serine/threonine-protein kinase mTOR [KO:K07203] [EC:2.7.11.1]
114709796  [KO:K00417]
114710174  [KO:K00417]
114710215  [KO:K02138]
114710475  Ndufa4; cytochrome c oxidase subunit NDUFA4 [KO:K03948]
114710697  Pln; cardiac phospholamban [KO:K05852]
114710722  Ndufb4; NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 4 [KO:K03960]
114710781  Slc25a31; ADP/ATP translocase 4 [KO:K05863]
114711016  [KO:K05863]
119087871  [KO:K04962]
119087872  [KO:K04962]
119088668  [KO:K02272]
36275531  ATP6; ATP synthase F0 subunit 6 [KO:K02126]
36275532  COX3; cytochrome c oxidase subunit III [KO:K02262]
36275535  ND4; NADH dehydrogenase subunit 4 [KO:K03881] [EC:7.1.1.2]
36275537  ND6; NADH dehydrogenase subunit 6 [KO:K03884] [EC:7.1.1.2]
36275544  ND1; NADH dehydrogenase subunit 1 [KO:K03878] [EC:7.1.1.2]
36275547  ND2; NADH dehydrogenase subunit 2 [KO:K03879] [EC:7.1.1.2]
36275552  COX1; cytochrome c oxidase subunit I [KO:K02256] [EC:7.1.1.9]
36275554  COX2; cytochrome c oxidase subunit II [KO:K02261]
36275555  ATP8; ATP synthase F0 subunit 8 [KO:K02125]
36275556  ND3; NADH dehydrogenase subunit 3 [KO:K03880] [EC:7.1.1.2]
36275557  ND4L; NADH dehydrogenase subunit 4L [KO:K03882] [EC:7.1.1.2]
36275560  ND5; NADH dehydrogenase subunit 5 [KO:K03883] [EC:7.1.1.2]
36275561  CYTB; cytochrome b [KO:K00412]
Compound
C00001  H2O
C00002  ATP
C00005  NADPH
C00006  NADP+
C00022  Pyruvate
C00024  Acetyl-CoA
C00027  Hydrogen peroxide
C00031  D-Glucose
C00043  UDP-N-acetyl-alpha-D-glucosamine
C00051  Glutathione
C00076  Calcium cation
C00085  D-Fructose 6-phosphate
C00092  D-Glucose 6-phosphate
C00095  D-Fructose
C00118  D-Glyceraldehyde 3-phosphate
C00127  Glutathione disulfide
C00162  Fatty acid
C00165  Diacylglycerol
C00195  N-Acylsphingosine
C00236  3-Phospho-D-glyceroyl phosphate
C00318  L-Carnitine
C00352  D-Glucosamine 6-phosphate
C00369  Starch
C00533  Nitric oxide
C00546  Methylglyoxal
C00704  Superoxide
C00794  D-Sorbitol
C00873  Angiotensin I
C02135  Angiotensin II
C02843  Long-chain acyl-CoA
C05981  Phosphatidylinositol-3,4,5-trisphosphate
C06156  alpha-D-Glucosamine 1-phosphate
C16844  Hydroxyl radical
C21011  [Protein]-N(epsilon)-(carboxymethyl)lysine
C21012  [Protein]-N(epsilon)-(carboxyethyl)lysine
C21013  [Protein]-pyrraline
C21014  [Protein]-pentosidine
C22310  Fructose 3-phosphate
C22311  3-Deoxyglucosone
Reference
PMID:30443826
  Authors
Riehle C, Bauersachs J
  Title
Of mice and men: models and mechanisms of diabetic cardiomyopathy.
  Journal
Basic Res Cardiol 114:2 (2018)
DOI:10.1007/s00395-018-0711-0
Reference
PMID:24462787
  Authors
Huynh K, Bernardo BC, McMullen JR, Ritchie RH
  Title
Diabetic cardiomyopathy: mechanisms and new treatment strategies targeting antioxidant signaling pathways.
  Journal
Pharmacol Ther 142:375-415 (2014)
DOI:10.1016/j.pharmthera.2014.01.003
Reference
PMID:28231848
  Authors
Lorenzo-Almoros A, Tunon J, Orejas M, Cortes M, Egido J, Lorenzo O
  Title
Diagnostic approaches for diabetic cardiomyopathy.
  Journal
Cardiovasc Diabetol 16:28 (2017)
DOI:10.1186/s12933-017-0506-x
Reference
PMID:32080423
  Authors
Tan Y, Zhang Z, Zheng C, Wintergerst KA, Keller BB, Cai L
  Title
Mechanisms of diabetic cardiomyopathy and potential therapeutic strategies: preclinical and clinical evidence.
  Journal
Nat Rev Cardiol 17:585-607 (2020)
DOI:10.1038/s41569-020-0339-2
Reference
PMID:31212580
  Authors
Zamora M, Villena JA
  Title
Contribution of Impaired Insulin Signaling to the Pathogenesis of Diabetic Cardiomyopathy.
  Journal
Int J Mol Sci 20:E2833 (2019)
DOI:10.3390/ijms20112833
Reference
PMID:29605388
  Authors
Palomer X, Pizarro-Delgado J, Vazquez-Carrera M
  Title
Emerging Actors in Diabetic Cardiomyopathy: Heartbreaker Biomarkers or Therapeutic Targets?
  Journal
Trends Pharmacol Sci 39:452-467 (2018)
DOI:10.1016/j.tips.2018.02.010
Reference
PMID:28439258
  Authors
Mishra PK, Ying W, Nandi SS, Bandyopadhyay GK, Patel KK, Mahata SK
  Title
Diabetic Cardiomyopathy: An Immunometabolic Perspective.
  Journal
Front Endocrinol (Lausanne) 8:72 (2017)
DOI:10.3389/fendo.2017.00072
Reference
PMID:28177068
  Authors
Chong CR, Clarke K, Levelt E
  Title
Metabolic Remodeling in Diabetic Cardiomyopathy.
  Journal
Cardiovasc Res 113:422-430 (2017)
DOI:10.1093/cvr/cvx018
Reference
PMID:11742414
  Authors
Brownlee M
  Title
Biochemistry and molecular cell biology of diabetic complications.
  Journal
Nature 414:813-20 (2001)
DOI:10.1038/414813a
Reference
PMID:32821697
  Authors
Gollmer J, Zirlik A, Bugger H
  Title
Established and Emerging Mechanisms of Diabetic Cardiomyopathy.
  Journal
J Lipid Atheroscler 8:26-47 (2019)
DOI:10.12997/jla.2019.8.1.26
Reference
PMID:17592090
  Authors
Boudina S, Abel ED
  Title
Diabetic cardiomyopathy revisited.
  Journal
Circulation 115:3213-23 (2007)
DOI:10.1161/CIRCULATIONAHA.106.679597
Reference
PMID:29109032
  Authors
Varma U, Koutsifeli P, Benson VL, Mellor KM, Delbridge LMD
  Title
Molecular mechanisms of cardiac pathology in diabetes - Experimental insights.
  Journal
Biochim Biophys Acta Mol Basis Dis 1864:1949-1959 (2018)
DOI:10.1016/j.bbadis.2017.10.035
Reference
PMID:23147391
  Authors
Mandavia CH, Aroor AR, Demarco VG, Sowers JR
  Title
Molecular and metabolic mechanisms of cardiac dysfunction in diabetes.
  Journal
Life Sci 92:601-8 (2013)
DOI:10.1016/j.lfs.2012.10.028
Reference
PMID:21626163
  Authors
Falcao-Pires I, Leite-Moreira AF
  Title
Diabetic cardiomyopathy: understanding the molecular and cellular basis to progress in diagnosis and treatment.
  Journal
Heart Fail Rev 17:325-44 (2012)
DOI:10.1007/s10741-011-9257-z
Reference
PMID:27148064
  Authors
Westermeier F, Riquelme JA, Pavez M, Garrido V, Diaz A, Verdejo HE, Castro PF, Garcia L, Lavandero S
  Title
New Molecular Insights of Insulin in Diabetic Cardiomyopathy.
  Journal
Front Physiol 7:125 (2016)
DOI:10.3389/fphys.2016.00125
Reference
PMID:33276047
  Authors
Randhawa VK, Dhanvantari S, Connelly K
  Title
How Diabetes and Heart Failure Modulate Each Other and Condition Management.
  Journal
Can J Cardiol S0828-282X(20)31115-6 (2020)
DOI:10.1016/j.cjca.2020.11.014
Reference
PMID:31641426
  Authors
Athithan L, Gulsin GS, McCann GP, Levelt E
  Title
Diabetic cardiomyopathy: Pathophysiology, theories and evidence to date.
  Journal
World J Diabetes 10:490-510 (2019)
DOI:10.4239/wjd.v10.i10.490
Reference
PMID:21111987
  Authors
Murarka S, Movahed MR
  Title
Diabetic cardiomyopathy.
  Journal
J Card Fail 16:971-9 (2010)
DOI:10.1016/j.cardfail.2010.07.249
Reference
PMID:25085967
  Authors
Thomas CM, Yong QC, Rosa RM, Seqqat R, Gopal S, Casarini DE, Jones WK, Gupta S, Baker KM, Kumar R
  Title
Cardiac-specific suppression of NF-kappaB signaling prevents diabetic cardiomyopathy via inhibition of the renin-angiotensin system.
  Journal
Am J Physiol Heart Circ Physiol 307:H1036-45 (2014)
DOI:10.1152/ajpheart.00340.2014
Reference
PMID:28236380
  Authors
Brahma MK, Pepin ME, Wende AR
  Title
My Sweetheart Is Broken: Role of Glucose in Diabetic Cardiomyopathy.
  Journal
Diabetes Metab J 41:1-9 (2017)
DOI:10.4093/dmj.2017.41.1.1
Reference
PMID:18829990
  Authors
Singh VP, Le B, Khode R, Baker KM, Kumar R
  Title
Intracellular angiotensin II production in diabetic rats is correlated with cardiomyocyte apoptosis, oxidative stress, and cardiac fibrosis.
  Journal
Diabetes 57:3297-306 (2008)
DOI:10.2337/db08-0805
Reference
PMID:18296558
  Authors
Singh VP, Baker KM, Kumar R
  Title
Activation of the intracellular renin-angiotensin system in cardiac fibroblasts by high glucose: role in extracellular matrix production.
  Journal
Am J Physiol Heart Circ Physiol 294:H1675-84 (2008)
DOI:10.1152/ajpheart.91493.2007
Reference
PMID:26678809
  Authors
Jia G, DeMarco VG, Sowers JR
  Title
Insulin resistance and hyperinsulinaemia in diabetic cardiomyopathy.
  Journal
Nat Rev Endocrinol 12:144-53 (2016)
DOI:10.1038/nrendo.2015.216
Reference
PMID:18309108
  Authors
Kim JA, Wei Y, Sowers JR
  Title
Role of mitochondrial dysfunction in insulin resistance.
  Journal
Circ Res 102:401-14 (2008)
DOI:10.1161/CIRCRESAHA.107.165472
Reference
PMID:30170598
  Authors
Ormazabal V, Nair S, Elfeky O, Aguayo C, Salomon C, Zuniga FA
  Title
Association between insulin resistance and the development of cardiovascular disease.
  Journal
Cardiovasc Diabetol 17:122 (2018)
DOI:10.1186/s12933-018-0762-4
Reference
PMID:31269778
  Authors
Evangelista I, Nuti R, Picchioni T, Dotta F, Palazzuoli A
  Title
Molecular Dysfunction and Phenotypic Derangement in Diabetic Cardiomyopathy.
  Journal
Int J Mol Sci 20:E3264 (2019)
DOI:10.3390/ijms20133264
Reference
PMID:24307101
  Authors
Joshi M, Kotha SR, Malireddy S, Selvaraju V, Satoskar AR, Palesty A, McFadden DW, Parinandi NL, Maulik N
  Title
Conundrum of pathogenesis of diabetic cardiomyopathy: role of vascular endothelial dysfunction, reactive oxygen species, and mitochondria.
  Journal
Mol Cell Biochem 386:233-49 (2014)
DOI:10.1007/s11010-013-1861-x
Reference
PMID:29867137
  Authors
Knapp M, Tu X, Wu R
  Title
Vascular endothelial dysfunction, a major mediator in diabetic cardiomyopathy.
  Journal
Acta Pharmacol Sin 40:1-8 (2019)
DOI:10.1038/s41401-018-0042-6
Reference
PMID:16487830
  Authors
Asbun J, Villarreal FJ
  Title
The pathogenesis of myocardial fibrosis in the setting of diabetic cardiomyopathy.
  Journal
J Am Coll Cardiol 47:693-700 (2006)
DOI:10.1016/j.jacc.2005.09.050
Reference
PMID:32024054
  Authors
Levick SP, Widiapradja A
  Title
The Diabetic Cardiac Fibroblast: Mechanisms Underlying Phenotype and Function.
  Journal
Int J Mol Sci 21:E970 (2020)
DOI:10.3390/ijms21030970
Related
pathway
pleu00010  Glycolysis / Gluconeogenesis
pleu00020  Citrate cycle (TCA cycle)
pleu00190  Oxidative phosphorylation
pleu00520  Amino sugar and nucleotide sugar metabolism
pleu03320  PPAR signaling pathway
pleu04071  Sphingolipid signaling pathway
pleu04150  mTOR signaling pathway
pleu04210  Apoptosis
pleu04260  Cardiac muscle contraction
pleu04350  TGF-beta signaling pathway
pleu04614  Renin-angiotensin system
pleu04910  Insulin signaling pathway
pleu04930  Type II diabetes mellitus
pleu04931  Insulin resistance
pleu04933  AGE-RAGE signaling pathway in diabetic complications
pleu04940  Type I diabetes mellitus
KO pathway
ko05415   

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