KEGG   PATHWAY: pvp04722
Entry
pvp04722                    Pathway                                
Name
Neurotrophin signaling pathway - Pteropus vampyrus (large flying fox)
Description
Neurotrophins are a family of trophic factors involved in differentiation and survival of neural cells. The neurotrophin family consists of nerve growth factor (NGF), brain derived neurotrophic factor (BDNF), neurotrophin 3 (NT-3), and neurotrophin 4 (NT-4). Neurotrophins exert their functions through engagement of Trk tyrosine kinase receptors or p75 neurotrophin receptor (p75NTR). Neurotrophin/Trk signaling is regulated by connecting a variety of intracellular signaling cascades, which include MAPK pathway, PI-3 kinase pathway, and PLC pathway, transmitting positive signals like enhanced survival and growth. On the other hand, p75NTR transmits both positive and nagative signals. These signals play an important role for neural development and additional higher-order activities such as learning and memory.
Class
Organismal Systems; Nervous system
Pathway map
pvp04722  Neurotrophin signaling pathway
pvp04722

Organism
Pteropus vampyrus (large flying fox) [GN:pvp]
Gene
105288499  NFKBIE; NF-kappa-B inhibitor epsilon [KO:K05872]
105288811  SHC4; SHC-transforming protein 4 [KO:K17449]
105288866  CAMK2G; calcium/calmodulin-dependent protein kinase type II subunit gamma isoform X2 [KO:K04515] [EC:2.7.11.17]
105288933  MAPK8; mitogen-activated protein kinase 8 isoform X1 [KO:K04440] [EC:2.7.11.24]
105289236  PTPN11; tyrosine-protein phosphatase non-receptor type 11 [KO:K07293] [EC:3.1.3.48]
105289311  CRKL; crk-like protein [KO:K04438]
105289326  MAPK1; mitogen-activated protein kinase 1 isoform X2 [KO:K04371] [EC:2.7.11.24]
105289385  SH2B3; SH2B adapter protein 3 [KO:K12459]
105289473  MAP3K5; mitogen-activated protein kinase kinase kinase 5 [KO:K04426] [EC:2.7.11.25]
105289628  MAPK10; mitogen-activated protein kinase 10 [KO:K04440] [EC:2.7.11.24]
105289863  PLCG2; 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-2 [KO:K05859] [EC:3.1.4.11]
105290063  TRAF6; TNF receptor-associated factor 6 [KO:K03175] [EC:2.3.2.27]
105290127  CALM1; calmodulin-1 [KO:K02183]
105290433  CDC42; cell division control protein 42 homolog isoform X1 [KO:K04393]
105290495  RPS6KA1; ribosomal protein S6 kinase alpha-1 isoform X1 [KO:K04373] [EC:2.7.11.1]
105291226  TP53; cellular tumor antigen p53 isoform X1 [KO:K04451]
105291313  MAPK7; mitogen-activated protein kinase 7 isoform X1 [KO:K04464] [EC:2.7.11.24]
105291564  GAB1; GRB2-associated-binding protein 1 isoform X7 [KO:K09593]
105291659  BRAF; serine/threonine-protein kinase B-raf isoform X1 [KO:K04365] [EC:2.7.11.1]
105291866  CRK; adapter molecule crk isoform X1 [KO:K04438]
105291867  YWHAE; 14-3-3 protein epsilon [KO:K06630]
105292607  PSEN2; presenilin-2 [KO:K04522] [EC:3.4.23.-]
105292717  BCL2; apoptosis regulator Bcl-2 isoform X2 [KO:K02161]
105292768  RPS6KA6; ribosomal protein S6 kinase alpha-6 [KO:K04373] [EC:2.7.11.1]
105292913  CALM2; calmodulin-2 isoform X1 [KO:K02183]
105292949  SOS1; son of sevenless homolog 1 isoform X1 [KO:K03099]
105293029  NFKB1; nuclear factor NF-kappa-B p105 subunit isoform X1 [KO:K02580]
105293353  GRB2; growth factor receptor-bound protein 2 isoform X1 [KO:K04364]
105293721  BDNF; brain-derived neurotrophic factor isoform X1 [KO:K04355]
105294032  RPS6KA3; ribosomal protein S6 kinase alpha-3 isoform X3 [KO:K04373] [EC:2.7.11.1]
105294059  KRAS; GTPase KRas isoform X2 [KO:K07827]
105294623  RAC1; LOW QUALITY PROTEIN: ras-related C3 botulinum toxin substrate 1 [KO:K04392]
105294748  IRS1; insulin receptor substrate 1 [KO:K16172]
105295250  FOXO3; forkhead box protein O3 [KO:K09408]
105295432  NGFR; tumor necrosis factor receptor superfamily member 16 [KO:K02583]
105295453  KIDINS220; kinase D-interacting substrate of 220 kDa [KO:K12460]
105295473  CAMK4; calcium/calmodulin-dependent protein kinase type IV isoform X1 [KO:K05869] [EC:2.7.11.17]
105295984  NTF3; neurotrophin-3 [KO:K04356]
105296379  SHC1; SHC-transforming protein 1 isoform X3 [KO:K06279]
105296416  NTRK1; high affinity nerve growth factor receptor [KO:K03176] [EC:2.7.10.1]
105296475  NGF; beta-nerve growth factor isoform X2 [KO:K02582]
105296521  PLCG1; 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1 [KO:K01116] [EC:3.1.4.11]
105296550  NRAS; GTPase NRas isoform X1 [KO:K07828]
105296605  PIK3R2; phosphatidylinositol 3-kinase regulatory subunit beta [KO:K02649]
105296884  RAP1A; ras-related protein Rap-1A [KO:K04353]
105297140  [KO:K02649]
105297275  SORT1; sortilin [KO:K12388]
105297322  CALM3; calmodulin-3 [KO:K02183]
105297485  IRAK4; interleukin-1 receptor-associated kinase 4 isoform X1 [KO:K04733] [EC:2.7.11.1]
105297731  MAP3K3; mitogen-activated protein kinase kinase kinase 3 isoform X3 [KO:K04421] [EC:2.7.11.25]
105297848  BAD; bcl2-associated agonist of cell death [KO:K02158]
105297999  RELA; transcription factor p65 [KO:K04735]
105298070  ATF4; cyclic AMP-dependent transcription factor ATF-4 [KO:K04374]
105298669  ABL1; tyrosine-protein kinase ABL1 [KO:K06619] [EC:2.7.10.2]
105298681  RAPGEF1; rap guanine nucleotide exchange factor 1 [KO:K06277]
105298702  AKT3; RAC-gamma serine/threonine-protein kinase isoform X1 [KO:K04456] [EC:2.7.11.1]
105299021  RAF1; RAF proto-oncogene serine/threonine-protein kinase isoform X1 [KO:K04366] [EC:2.7.11.1]
105299033  IRAK2; interleukin-1 receptor-associated kinase-like 2 [KO:K04731] [EC:2.7.11.1]
105299180  [KO:K02183]
105299201  TP73; tumor protein p73 [KO:K10148]
105299254  PSEN1; presenilin-1 [KO:K04505] [EC:3.4.23.-]
105299360  MAP3K1; mitogen-activated protein kinase kinase kinase 1 isoform X1 [KO:K04416] [EC:2.7.11.25]
105299371  PIK3R1; phosphatidylinositol 3-kinase regulatory subunit alpha isoform X3 [KO:K02649]
105299441  CAMK2A; calcium/calmodulin-dependent protein kinase type II subunit alpha [KO:K04515] [EC:2.7.11.17]
105299711  SH2B2; SH2B adapter protein 2 [KO:K07193]
105299797  FASLG; tumor necrosis factor ligand superfamily member 6 [KO:K04389]
105299978  MAPK9; mitogen-activated protein kinase 9 isoform X1 [KO:K04440] [EC:2.7.11.24]
105300054  NTRK2; BDNF/NT-3 growth factors receptor [KO:K04360] [EC:2.7.10.1]
105300159  [KO:K04456] [EC:2.7.11.1]
105300180  NFKBIB; NF-kappa-B inhibitor beta [KO:K02581]
105300265  SHC3; SHC-transforming protein 3 [KO:K17448]
105300449  MATK; megakaryocyte-associated tyrosine-protein kinase [KO:K08888] [EC:2.7.10.2]
105300805  RPS6KA5; ribosomal protein S6 kinase alpha-5 [KO:K04445] [EC:2.7.11.1]
105301022  IKBKB; inhibitor of nuclear factor kappa-B kinase subunit beta [KO:K07209] [EC:2.7.11.10]
105301035  MAPK14; mitogen-activated protein kinase 14 isoform X1 [KO:K04441] [EC:2.7.11.24]
105301036  MAPK13; mitogen-activated protein kinase 13 [KO:K04441] [EC:2.7.11.24]
105301143  ARHGDIA; rho GDP-dissociation inhibitor 1 [KO:K12462]
105301304  GSK3B; glycogen synthase kinase-3 beta isoform X1 [KO:K03083] [EC:2.7.11.26]
105301406  FRS2; fibroblast growth factor receptor substrate 2 [KO:K12461]
105301755  [KO:K12457]
105301756  NTF4; neurotrophin-4 [KO:K12457]
105301762  BAX; apoptosis regulator BAX isoform X1 [KO:K02159]
105302138  IRAK3; interleukin-1 receptor-associated kinase 3 [KO:K04732] [EC:2.7.11.1]
105302160  RAP1B; ras-related protein Rap-1b [KO:K07836]
105302278  SHC2; SHC-transforming protein 2 [KO:K17447]
105302383  RHOA; transforming protein RhoA [KO:K04513]
105302526  IRAK1; interleukin-1 receptor-associated kinase 1 isoform X1 [KO:K04730] [EC:2.7.11.1]
105302767  CAMK2D; calcium/calmodulin-dependent protein kinase type II subunit delta [KO:K04515] [EC:2.7.11.17]
105302769  ARHGDIB; rho GDP-dissociation inhibitor 2 [KO:K12462]
105303144  PDPK1; 3-phosphoinositide-dependent protein kinase 1 [KO:K06276] [EC:2.7.11.1]
105303182  NFKBIA; NF-kappa-B inhibitor alpha [KO:K04734]
105303250  ARHGDIG; rho GDP-dissociation inhibitor 3 [KO:K12462]
105303436  JUN; transcription factor AP-1 [KO:K04448]
105303606  CALML6; calmodulin-like protein 6 [KO:K02183]
105303899  AKT1; RAC-alpha serine/threonine-protein kinase [KO:K04456] [EC:2.7.11.1]
105304146  RIPK2; receptor-interacting serine/threonine-protein kinase 2 isoform X1 [KO:K08846] [EC:2.7.11.1]
105304348  PRKCD; protein kinase C delta type isoform X1 [KO:K06068] [EC:2.7.11.13]
105304566  MAPK3; mitogen-activated protein kinase 3 isoform X1 [KO:K04371] [EC:2.7.11.24]
105304580  SH2B1; SH2B adapter protein 1 isoform X1 [KO:K12459]
105305933  HRAS; GTPase HRas isoform X1 [KO:K02833]
105306725  [KO:K05101] [EC:2.7.10.1]
105306744  MAP2K2; dual specificity mitogen-activated protein kinase kinase 2 [KO:K04369] [EC:2.7.12.2]
105307215  PIK3CD; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform isoform X1 [KO:K00922] [EC:2.7.1.153]
105307369  [KO:K04373] [EC:2.7.11.1]
105307575  PIK3CA; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform [KO:K00922] [EC:2.7.1.153]
105307700  MAP2K7; dual specificity mitogen-activated protein kinase kinase 7 [KO:K04431] [EC:2.7.12.2]
105308283  [KO:K04441] [EC:2.7.11.24]
105308643  [KO:K12458]
105308762  CAMK2B; calcium/calmodulin-dependent protein kinase type II subunit beta [KO:K04515] [EC:2.7.11.17]
105308925  MAPKAPK2; MAP kinase-activated protein kinase 2 isoform X1 [KO:K04443] [EC:2.7.11.1]
105308956  PIK3CB; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform isoform X2 [KO:K00922] [EC:2.7.1.153]
105308996  BEX3; protein BEX3 isoform X1 [KO:K12465]
105309535  SOS2; son of sevenless homolog 2 [KO:K03099]
105309689  CALML4; LOW QUALITY PROTEIN: calmodulin-like protein 4 [KO:K02183]
105309698  MAP2K5; dual specificity mitogen-activated protein kinase kinase 5 isoform X1 [KO:K04463] [EC:2.7.12.2]
105309827  MAP2K1; dual specificity mitogen-activated protein kinase kinase 1 isoform X1 [KO:K04368] [EC:2.7.12.2]
105309828  [KO:K07293] [EC:3.1.3.48]
105310045  MAGED1; melanoma-associated antigen D1 [KO:K12464]
105310642  [KO:K04730] [EC:2.7.11.1]
105311074  PRDM4; PR domain zinc finger protein 4 isoform X1 [KO:K12463] [EC:2.1.1.-]
Compound
C00076  Calcium cation
C00165  Diacylglycerol
C00195  N-Acylsphingosine
C01245  D-myo-Inositol 1,4,5-trisphosphate
C05981  Phosphatidylinositol-3,4,5-trisphosphate
Reference
PMID:12676795
  Authors
Huang EJ, Reichardt LF.
  Title
Trk receptors: roles in neuronal signal transduction.
  Journal
Annu Rev Biochem 72:609-42 (2003)
DOI:10.1146/annurev.biochem.72.121801.161629
Reference
PMID:11399424
  Authors
Patapoutian A, Reichardt LF
  Title
Trk receptors: mediators of neurotrophin action.
  Journal
Curr Opin Neurobiol 11:272-80 (2001)
DOI:10.1016/S0959-4388(00)00208-7
Reference
PMID:16699811
  Authors
Arevalo JC, Wu SH
  Title
Neurotrophin signaling: many exciting surprises!
  Journal
Cell Mol Life Sci 63:1523-37 (2006)
DOI:10.1007/s00018-006-6010-1
Reference
PMID:14704852
  Authors
Teng KK, Hempstead BL
  Title
Neurotrophins and their receptors: signaling trios in complex biological systems.
  Journal
Cell Mol Life Sci 61:35-48 (2004)
DOI:10.1007/s00018-003-3099-3
Reference
PMID:11529497
  Authors
Miller FD, Kaplan DR
  Title
Neurotrophin signalling pathways regulating neuronal apoptosis.
  Journal
Cell Mol Life Sci 58:1045-53 (2001)
DOI:10.1007/PL00000919
Reference
PMID:10851172
  Authors
Kaplan DR, Miller FD
  Title
Neurotrophin signal transduction in the nervous system.
  Journal
Curr Opin Neurobiol 10:381-91 (2000)
DOI:10.1016/S0959-4388(00)00092-1
Reference
PMID:16939974
  Authors
Reichardt LF
  Title
Neurotrophin-regulated signalling pathways.
  Journal
Philos Trans R Soc Lond B Biol Sci 361:1545-64 (2006)
DOI:10.1098/rstb.2006.1894
Reference
PMID:16856873
  Authors
Zampieri N, Chao MV
  Title
Mechanisms of neurotrophin receptor signalling.
  Journal
Biochem Soc Trans 34:607-11 (2006)
DOI:10.1042/BST0340607
Reference
PMID:15499580
  Authors
Rose CR, Blum R, Kafitz KW, Kovalchuk Y, Konnerth A
  Title
From modulator to mediator: rapid effects of BDNF on ion channels.
  Journal
Bioessays 26:1185-94 (2004)
DOI:10.1002/bies.20118
Reference
PMID:10812966
  Authors
Yano H, Chao MV
  Title
Neurotrophin receptor structure and interactions.
  Journal
Pharm Acta Helv 74:253-60 (2000)
DOI:10.1016/s0031-6865(99)00036-9
Reference
PMID:10764727
  Authors
Mukai J, Hachiya T, Shoji-Hoshino S, Kimura MT, Nadano D, Suvanto P, Hanaoka T, Li Y, Irie S, Greene LA, Sato TA
  Title
NADE, a p75NTR-associated cell death executor, is involved in signal transduction mediated by the common neurotrophin receptor p75NTR.
  Journal
J Biol Chem 275:17566-70 (2000)
DOI:10.1074/jbc.C000140200
Reference
PMID:10985348
  Authors
Salehi AH, Roux PP, Kubu CJ, Zeindler C, Bhakar A, Tannis LL, Verdi JM, Barker PA
  Title
NRAGE, a novel MAGE protein, interacts with the p75 neurotrophin receptor and facilitates nerve growth factor-dependent apoptosis.
  Journal
Neuron 27:279-88 (2000)
DOI:10.1016/S0896-6273(00)00036-2
Related
pathway
pvp04010  MAPK signaling pathway
pvp04120  Ubiquitin mediated proteolysis
pvp04210  Apoptosis
pvp04720  Long-term potentiation
pvp04810  Regulation of actin cytoskeleton
KO pathway
ko04722   

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