KEGG   PATHWAY: rfq04020
Entry
rfq04020                    Pathway                                
Name
Calcium signaling pathway - Rhinolophus ferrumequinum (greater horseshoe bat)
Description
Ca2+ that enters the cell from the outside is a principal source of signal Ca2+. Entry of Ca2+ is driven by the presence of a large electrochemical gradient across the plasma membrane. Cells use this external source of signal Ca2+ by activating various entry channels with widely different properties. The voltage-operated channels (VOCs) are found in excitable cells and generate the rapid Ca2+ fluxes that control fast cellular processes. There are many other Ca2+-entry channels, such as the receptor-operated channels (ROCs), for example the NMDA (N-methyl-D-aspartate) receptors (NMDARs) that respond to glutamate. There also are second-messenger-operated channels (SMOCs) and store-operated channels (SOCs).
The other principal source of Ca2+ for signalling is the internal stores that are located primarily in the endoplasmic/sarcoplasmic reticulum (ER/SR), in which inositol-1,4,5-trisphosphate receptors (IP3Rs) or ryanodine receptors (RYRs) regulate the release of Ca2+. The principal activator of these channels is Ca2+ itself and this process of Ca2+-induced Ca2+ release is central to the mechanism of Ca2+ signalling. Various second messengers or modulators also control the release of Ca2+. IP3, which is generated by pathways using different isoforms of phospholipase C (PLCbeta, delta, epsilon, gamma and zeta), regulates the IP3Rs. Cyclic ADP-ribose (cADPR) releases Ca2+ via RYRs. Nicotinic acid adenine dinucleotide phosphate (NAADP) may activate a distinct Ca2+ release mechanism on separate acidic Ca2+ stores. Ca2+ release via the NAADP-sensitive mechanism may also feedback onto either RYRs or IP3Rs. cADPR and NAADP are generated by CD38. This enzyme might be sensitive to the cellular metabolism, as ATP and NADH inhibit it.
The influx of Ca2+ from the environment or release from internal stores causes a very rapid and dramatic increase in cytoplasmic calcium concentration, which has been widely exploited for signal transduction. Some proteins, such as troponin C (TnC) involved in muscle contraction, directly bind to and sense Ca2+. However, in other cases Ca2+ is sensed through intermediate calcium sensors such as calmodulin (CALM).
Class
Environmental Information Processing; Signal transduction
Pathway map
rfq04020  Calcium signaling pathway
rfq04020

Other DBs
GO: 0019722
Organism
Rhinolophus ferrumequinum (greater horseshoe bat) [GN:rfq]
Gene
117032937  SLC8A1; sodium/calcium exchanger 1 isoform X1 [KO:K05849]
117034406  SLC8A2; sodium/calcium exchanger 2 isoform X1 [KO:K05849]
117023466  SLC8A3; sodium/calcium exchanger 3 isoform X1 [KO:K05849]
117022277  ATP2B3; plasma membrane calcium-transporting ATPase 3 isoform X1 [KO:K05850] [EC:7.2.2.10]
117029241  ATP2B1; plasma membrane calcium-transporting ATPase 1 isoform X1 [KO:K05850] [EC:7.2.2.10]
117015109  ATP2B4; plasma membrane calcium-transporting ATPase 4 isoform X1 [KO:K05850] [EC:7.2.2.10]
117036555  ATP2B2; plasma membrane calcium-transporting ATPase 2 isoform X1 [KO:K05850] [EC:7.2.2.10]
117030679  CHRM1; muscarinic acetylcholine receptor M1 [KO:K04129]
117018403  CHRM3; muscarinic acetylcholine receptor M3 [KO:K04131]
117023258  CHRM5; muscarinic acetylcholine receptor M5 [KO:K04133]
117017888  ADORA2A; adenosine receptor A2a [KO:K04266]
117013484  ADORA2B; adenosine receptor A2b [KO:K04267]
117035752  ADRB1; beta-1 adrenergic receptor [KO:K04141]
117016786  ADRB2; beta-2 adrenergic receptor [KO:K04142]
117021619  ADRB3; beta-3 adrenergic receptor isoform X1 [KO:K04143]
117016476  DRD1; D(1A) dopamine receptor [KO:K04144]
117022660  DRD5; D(1B) dopamine receptor [KO:K05840]
117016426  HRH2; histamine H2 receptor [KO:K04150]
117016453  HTR4; 5-hydroxytryptamine receptor 4 [KO:K04160]
117018185  HTR5A; 5-hydroxytryptamine receptor 5A [KO:K04161]
117026009  5-hydroxytryptamine receptor 5B [KO:K04161]
117027278  HTR6; 5-hydroxytryptamine receptor 6 [KO:K04162]
117035767  HTR7; 5-hydroxytryptamine receptor 7 [KO:K04163]
117015708  neuroendocrine secretory protein 55 [KO:K04632]
117015705  GNAS; guanine nucleotide-binding protein G(s) subunit alpha isoforms XLas isoform X1 [KO:K04632]
117038743  GNAL; guanine nucleotide-binding protein G(olf) subunit alpha isoform X1 [KO:K04633]
117012305  ADCY1; adenylate cyclase type 1 isoform X1 [KO:K08041] [EC:4.6.1.1]
117025090  ADCY2; adenylate cyclase type 2 [KO:K08042] [EC:4.6.1.1]
117032856  ADCY3; adenylate cyclase type 3 isoform X1 [KO:K08043] [EC:4.6.1.1]
117024169  ADCY4; adenylate cyclase type 4 isoform X1 [KO:K08044] [EC:4.6.1.1]
117034378  ADCY7; adenylate cyclase type 7 isoform X1 [KO:K08047] [EC:4.6.1.1]
117033942  ADCY8; adenylate cyclase type 8 isoform X1 [KO:K08048] [EC:4.6.1.1]
117019474  ADCY9; adenylate cyclase type 9 [KO:K08049] [EC:4.6.1.1]
117027001  PRKACB; cAMP-dependent protein kinase catalytic subunit beta isoform X1 [KO:K04345] [EC:2.7.11.11]
117037860  PRKACA; cAMP-dependent protein kinase catalytic subunit alpha [KO:K04345] [EC:2.7.11.11]
117020477  PLN; cardiac phospholamban [KO:K05852]
117030624  SLN; sarcolipin [KO:K22642]
117036396  MRLN; myoregulin [KO:K22643]
117013992  SMIM6; small integral membrane protein 6 [KO:K26468]
117017773  ATP2A2; sarcoplasmic/endoplasmic reticulum calcium ATPase 2 [KO:K05853] [EC:7.2.2.10]
117019508  ATP2A1; sarcoplasmic/endoplasmic reticulum calcium ATPase 1 isoform X1 [KO:K05853] [EC:7.2.2.10]
117013297  ATP2A3; sarcoplasmic/endoplasmic reticulum calcium ATPase 3 isoform X1 [KO:K05853] [EC:7.2.2.10]
117034822  HRC; sarcoplasmic reticulum histidine-rich calcium-binding protein [KO:K23450]
117030118  STIM1; stromal interaction molecule 1 isoform X1 [KO:K16059]
117022374  STIM2; stromal interaction molecule 2 [KO:K18196]
117017478  ORAI1; calcium release-activated calcium channel protein 1 [KO:K16056]
117024739  ORAI2; protein orai-2 isoform X1 [KO:K16057]
117019836  ORAI3; protein orai-3 [KO:K16058]
117029264  CACNA1C; voltage-dependent L-type calcium channel subunit alpha-1C isoform X1 [KO:K04850]
117036785  CACNA1D; voltage-dependent L-type calcium channel subunit alpha-1D isoform X1 [KO:K04851]
117023033  CACNA1F; voltage-dependent L-type calcium channel subunit alpha-1F isoform X1 [KO:K04853]
117018578  CACNA1S; voltage-dependent L-type calcium channel subunit alpha-1S isoform X1 [KO:K04857]
117037598  CACNA1A; voltage-dependent P/Q-type calcium channel subunit alpha-1A isoform X1 [KO:K04344]
117032070  CACNA1B; LOW QUALITY PROTEIN: voltage-dependent N-type calcium channel subunit alpha-1B [KO:K04849]
117014566  CACNA1E; voltage-dependent R-type calcium channel subunit alpha-1E isoform X1 [KO:K04852]
117012898  CACNA1G; voltage-dependent T-type calcium channel subunit alpha-1G isoform X1 [KO:K04854]
117019723  CACNA1H; voltage-dependent T-type calcium channel subunit alpha-1H isoform X1 [KO:K04855]
117028679  CACNA1I; voltage-dependent T-type calcium channel subunit alpha-1I [KO:K04856]
117018979  neuronal acetylcholine receptor subunit alpha-7 isoform X1 [KO:K04809]
117031907  GRIN1; glutamate receptor ionotropic, NMDA 1 isoform X1 [KO:K05208]
117019640  GRIN2A; glutamate receptor ionotropic, NMDA 2A [KO:K05209]
117029473  GRIN2B; glutamate receptor ionotropic, NMDA 2B [KO:K05210]
117013780  GRIN2C; glutamate receptor ionotropic, NMDA 2C isoform X1 [KO:K05211]
117034330  GRIN2D; glutamate receptor ionotropic, NMDA 2D [KO:K05212]
117032504  GRIN3A; glutamate receptor ionotropic, NMDA 3A [KO:K05213]
117037567  GRIN3B; glutamate receptor ionotropic, NMDA 3B [KO:K05214]
117012973  P2RX1; P2X purinoceptor 1 isoform X1 [KO:K05215]
117017541  P2RX2; P2X purinoceptor 2 isoform X1 [KO:K05216]
117031100  P2RX3; P2X purinoceptor 3 [KO:K05217]
117017318  P2RX4; P2X purinoceptor 4 [KO:K05218]
117012972  P2RX5; P2X purinoceptor 5 isoform X1 [KO:K05219]
117017397  P2RX6; P2X purinoceptor 6 isoform X1 [KO:K05221]
117017316  P2RX7; P2X purinoceptor 7 isoform X1 [KO:K05220]
117034373  RYR1; LOW QUALITY PROTEIN: ryanodine receptor 1 [KO:K04961]
117018496  RYR2; ryanodine receptor 2 isoform X1 [KO:K04962]
117023262  RYR3; ryanodine receptor 3 [KO:K04963]
117020507  triadin-like [KO:K23449]
117020508  LOW QUALITY PROTEIN: triadin-like [KO:K23449]
117015201  CASQ1; calsequestrin-1 [KO:K23468]
117014271  CASQ2; calsequestrin-2 [KO:K23445]
117034001  ASPH; aspartyl/asparaginyl beta-hydroxylase isoform X1 [KO:K00476] [EC:1.14.11.16]
117023197  CYSLTR1; cysteinyl leukotriene receptor 1 [KO:K04322]
117021075  CYSLTR2; cysteinyl leukotriene receptor 2 [KO:K04323]
117018247  CHRM2; muscarinic acetylcholine receptor M2 [KO:K04130]
117037795  ADRA1A; alpha-1A adrenergic receptor isoform X1 [KO:K04135]
117017105  ADRA1B; alpha-1B adrenergic receptor [KO:K04136]
117016187  ADRA1D; alpha-1D adrenergic receptor [KO:K04137]
117013699  AGTR1; type-1 angiotensin II receptor [KO:K04166]
117038242  EDNRA; endothelin-1 receptor [KO:K04197]
117021669  EDNRB; endothelin receptor type B isoform X1 [KO:K04198]
117025288  F2R; proteinase-activated receptor 1 [KO:K03914]
117020443  GRM1; metabotropic glutamate receptor 1 isoform X1 [KO:K04603]
117030808  GRM5; metabotropic glutamate receptor 5 isoform X1 [KO:K04604]
117027244  GRPR; gastrin-releasing peptide receptor [KO:K04169]
117036598  HRH1; histamine H1 receptor [KO:K04149]
117025878  HTR2B; 5-hydroxytryptamine receptor 2B [KO:K04157]
117021040  HTR2A; 5-hydroxytryptamine receptor 2A [KO:K04157]
117036590  HTR2C; LOW QUALITY PROTEIN: 5-hydroxytryptamine receptor 2C [KO:K04157]
117033138  LHCGR; lutropin-choriogonadotropic hormone receptor [KO:K04248]
117015718  NTSR1; neurotensin receptor type 1 [KO:K04211]
117036998  OXTR; oxytocin receptor isoform X1 [KO:K04229]
117027995  AVPR1A; vasopressin V1a receptor [KO:K04226]
117014850  AVPR1B; vasopressin V1b receptor isoform X1 [KO:K04227]
117023275  LTB4R2; leukotriene B4 receptor 2 [KO:K04297]
117027819  PTAFR; platelet-activating factor receptor isoform X1 [KO:K04279]
117038390  PTGER1; prostaglandin E2 receptor EP1 subtype isoform X1 [KO:K04258]
117027591  PTGER3; prostaglandin E2 receptor EP3 subtype [KO:K04260]
117028151  prostaglandin E2 receptor EP3 subtype-like [KO:K04260]
117026550  PTGFR; prostaglandin F2-alpha receptor [KO:K04262]
117022850  BDKRB1; B1 bradykinin receptor isoform X1 [KO:K03915]
117023958  BDKRB2; B2 bradykinin receptor [KO:K03916]
117032657  TACR1; substance-P receptor [KO:K04222]
117036228  TACR2; substance-K receptor [KO:K04223]
117022381  TACR3; neuromedin-K receptor [KO:K04224]
117037637  TBXA2R; thromboxane A2 receptor [KO:K04264]
117033987  TRHR; thyrotropin-releasing hormone receptor [KO:K04282]
117034793  LOW QUALITY PROTEIN: thyrotropin-releasing hormone receptor-like [KO:K04282]
117021973  CCKAR; cholecystokinin receptor type A [KO:K04194]
117031299  CCKBR; gastrin/cholecystokinin type B receptor isoform X1 [KO:K04195]
117026300  CXCR4; C-X-C chemokine receptor type 4 [KO:K04189]
117031869  GNAQ; guanine nucleotide-binding protein G(q) subunit alpha [KO:K04634]
117037515  GNA11; guanine nucleotide-binding protein subunit alpha-11 [KO:K04635]
117032357  GNA14; guanine nucleotide-binding protein subunit alpha-14 [KO:K04636]
117037513  GNA15; guanine nucleotide-binding protein subunit alpha-15 [KO:K04637]
117021897  EGF; pro-epidermal growth factor isoform X1 [KO:K04357]
117033382  TGFA; protransforming growth factor alpha isoform X1 [KO:K08774]
117016876  PDGFA; platelet-derived growth factor subunit A isoform X1 [KO:K04359]
117029043  PDGFB; platelet-derived growth factor subunit B [KO:K17386]
117031167  PDGFD; platelet-derived growth factor D isoform X1 [KO:K05450]
117038535  PDGFC; platelet-derived growth factor C [KO:K05450]
117016625  FGF1; fibroblast growth factor 1 isoform X1 [KO:K18496]
117037862  FGF2; LOW QUALITY PROTEIN: fibroblast growth factor 2 [KO:K18497]
117025364  FGF10; fibroblast growth factor 10 [KO:K04358]
117027635  FGF16; fibroblast growth factor 16 [KO:K04358]
117021496  FGF20; fibroblast growth factor 20 [KO:K04358]
117021758  FGF9; fibroblast growth factor 9 [KO:K04358]
117028974  FGF6; fibroblast growth factor 6 [KO:K04358]
117022308  FGF5; fibroblast growth factor 5 isoform X1 [KO:K04358]
117036181  FGF8; fibroblast growth factor 8 isoform X1 [KO:K04358]
117030196  FGF3; fibroblast growth factor 3 [KO:K04358]
117030198  FGF4; fibroblast growth factor 4 [KO:K04358]
117023393  FGF7; fibroblast growth factor 7 [KO:K04358]
117016767  FGF18; fibroblast growth factor 18 [KO:K04358]
117038202  FGF17; fibroblast growth factor 17 isoform X1 [KO:K04358]
117038267  FGF22; fibroblast growth factor 22 [KO:K04358]
117030197  FGF19; fibroblast growth factor 19 [KO:K22603]
117035017  FGF21; fibroblast growth factor 21 [KO:K22429]
117028661  FGF23; fibroblast growth factor 23 [KO:K22428]
117016780  VEGFA; vascular endothelial growth factor A isoform X1 [KO:K05448]
117031344  VEGFB; vascular endothelial growth factor B isoform X1 [KO:K16858]
117025800  VEGFD; vascular endothelial growth factor D [KO:K05449]
117021086  VEGFC; vascular endothelial growth factor C isoform X1 [KO:K05449]
117014821  NGF; beta-nerve growth factor [KO:K02582]
117012542  HGF; hepatocyte growth factor isoform X1 [KO:K05460]
117036808  MST1; hepatocyte growth factor-like protein [KO:K23441]
117024944  GDNF; LOW QUALITY PROTEIN: glial cell line-derived neurotrophic factor [KO:K05452]
117012187  EGFR; epidermal growth factor receptor isoform X1 [KO:K04361] [EC:2.7.10.1]
117013264  ERBB2; receptor tyrosine-protein kinase erbB-2 [KO:K05083] [EC:2.7.10.1]
117028913  ERBB3; receptor tyrosine-protein kinase erbB-3 isoform X1 [KO:K05084] [EC:2.7.10.1]
117026370  ERBB4; LOW QUALITY PROTEIN: receptor tyrosine-protein kinase erbB-4 [KO:K05085] [EC:2.7.10.1]
117022011  PDGFRA; platelet-derived growth factor receptor alpha isoform X1 [KO:K04363] [EC:2.7.10.1]
117016666  PDGFRB; platelet-derived growth factor receptor beta isoform X1 [KO:K05089] [EC:2.7.10.1]
117021283  FGFR1; fibroblast growth factor receptor 1 isoform X1 [KO:K04362] [EC:2.7.10.1]
117035827  FGFR2; fibroblast growth factor receptor 2 isoform X1 [KO:K05093] [EC:2.7.10.1]
117022243  FGFR3; fibroblast growth factor receptor 3 isoform X1 [KO:K05094] [EC:2.7.10.1]
117017069  FGFR4; fibroblast growth factor receptor 4 [KO:K05095] [EC:2.7.10.1]
117026978  vascular endothelial growth factor receptor kdr-like [KO:K05096] [EC:2.7.10.1]
117021297  FLT1; vascular endothelial growth factor receptor 1 [KO:K05096] [EC:2.7.10.1]
117016973  FLT4; vascular endothelial growth factor receptor 3 isoform X1 [KO:K05097] [EC:2.7.10.1]
117022432  KDR; vascular endothelial growth factor receptor 2 isoform X1 [KO:K05098] [EC:2.7.10.1]
117014296  NTRK1; high affinity nerve growth factor receptor [KO:K03176] [EC:2.7.10.1]
117032168  NTRK2; BDNF/NT-3 growth factors receptor isoform X1 [KO:K04360] [EC:2.7.10.1]
117018962  NTRK3; NT-3 growth factor receptor isoform X1 [KO:K05101] [EC:2.7.10.1]
117018153  MET; hepatocyte growth factor receptor isoform X1 [KO:K05099] [EC:2.7.10.1]
117037275  MST1R; macrophage-stimulating protein receptor isoform X1 [KO:K05100] [EC:2.7.10.1]
117036190  RET; proto-oncogene tyrosine-protein kinase receptor Ret [KO:K05126] [EC:2.7.10.1]
117017992  uncharacterized protein LOC117017992 [KO:K10785]
117024085  uncharacterized protein LOC117024085 [KO:K06856]
117025747  PLCD4; LOW QUALITY PROTEIN: 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase delta-4 [KO:K05857] [EC:3.1.4.11]
117013696  PLCD3; 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase delta-3 [KO:K05857] [EC:3.1.4.11]
117037324  PLCD1; 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase delta-1 isoform X1 [KO:K05857] [EC:3.1.4.11]
117015870  PLCB1; 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-1 isoform X1 [KO:K05858] [EC:3.1.4.11]
117015942  PLCB4; 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-4 isoform X1 [KO:K05858] [EC:3.1.4.11]
117030619  PLCB3; 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-3 [KO:K05858] [EC:3.1.4.11]
117024110  PLCB2; 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-2 [KO:K05858] [EC:3.1.4.11]
117015909  PLCG1; 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1 isoform X1 [KO:K01116] [EC:3.1.4.11]
117034806  PLCG2; 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-2 [KO:K05859] [EC:3.1.4.11]
117036083  PLCE1; 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase epsilon-1 isoform X1 [KO:K05860] [EC:3.1.4.11]
117029289  PLCZ1; 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase zeta-1 [KO:K05861] [EC:3.1.4.11]
117037173  ITPR1; inositol 1,4,5-trisphosphate receptor type 1 isoform X1 [KO:K04958]
117028439  ITPR2; inositol 1,4,5-trisphosphate receptor type 2 isoform X1 [KO:K04959]
117020871  ITPR3; inositol 1,4,5-trisphosphate receptor type 3 [KO:K04960]
117021922  ADP-ribosyl cyclase/cyclic ADP-ribose hydrolase 1-like [KO:K01242] [EC:3.2.2.6 2.4.99.20]
117021923  ADP-ribosyl cyclase/cyclic ADP-ribose hydrolase 1-like [KO:K01242] [EC:3.2.2.6 2.4.99.20]
117017693  TPCN1; two pore calcium channel protein 1 isoform X1 [KO:K16896]
117031237  TPCN2; two pore calcium channel protein 2 isoform X1 [KO:K14077]
117037543  MCOLN1; mucolipin-1 [KO:K04992]
117027821  MCOLN2; mucolipin-2 [KO:K04993]
117027211  MCOLN3; mucolipin-3 isoform X1 [KO:K04994]
117013008  SPHK1; sphingosine kinase 1 isoform X1 [KO:K04718] [EC:2.7.1.91]
117035218  SPHK2; sphingosine kinase 2 isoform X1 [KO:K04718] [EC:2.7.1.91]
117036103  MCU; calcium uniporter protein, mitochondrial [KO:K20858]
117016684  VDAC1; voltage-dependent anion-selective channel protein 1 [KO:K05862]
117036062  VDAC2; voltage-dependent anion-selective channel protein 2 [KO:K15040]
117021686  VDAC3; voltage-dependent anion-selective channel protein 3 isoform X1 [KO:K15041]
117021321  SLC25A4; LOW QUALITY PROTEIN: ADP/ATP translocase 1 [KO:K05863]
117028369  SLC25A5; ADP/ATP translocase 2 [KO:K05863]
117035497  LOW QUALITY PROTEIN: ADP/ATP translocase 3-like [KO:K05863]
117036658  SLC25A6; ADP/ATP translocase 3 [KO:K05863]
117037410  SLC25A31; ADP/ATP translocase 4 [KO:K05863]
117023833  LOW QUALITY PROTEIN: ADP/ATP translocase 2-like [KO:K05863]
117036342  PPIF; peptidyl-prolyl cis-trans isomerase F, mitochondrial [KO:K09565] [EC:5.2.1.8]
117036991  TNNC1; troponin C, slow skeletal and cardiac muscles [KO:K05865]
117015989  TNNC2; troponin C, skeletal muscle [KO:K12042]
117026472  CALML6; calmodulin-like protein 6 [KO:K02183]
117033010  CALM2; calmodulin-2 [KO:K02183]
117019182  calmodulin-like [KO:K02183]
117019237  calmodulin-like protein 3 [KO:K02183]
117013546  calmodulin-1-like [KO:K02183]
117034856  CALM3; calmodulin-3 [KO:K02183]
117022841  CALM1; calmodulin-1 [KO:K02183]
117023064  CALML4; LOW QUALITY PROTEIN: calmodulin-like protein 4 [KO:K02183]
117019729  PHKG2; phosphorylase b kinase gamma catalytic chain, liver/testis isoform isoform X1 [KO:K00871] [EC:2.7.11.19]
117024807  PHKG1; phosphorylase b kinase gamma catalytic chain, skeletal muscle/heart isoform [KO:K00871] [EC:2.7.11.19]
117034776  PHKB; phosphorylase b kinase regulatory subunit beta isoform X1 [KO:K07190]
117022677  PHKA2; phosphorylase b kinase regulatory subunit alpha, liver isoform isoform X1 [KO:K07190]
117023113  PHKA1; phosphorylase b kinase regulatory subunit alpha, skeletal muscle isoform isoform X1 [KO:K07190]
117026833  MYLK4; myosin light chain kinase family member 4 isoform X1 [KO:K00907] [EC:2.7.11.18]
117013453  MYLK; myosin light chain kinase, smooth muscle [KO:K00907] [EC:2.7.11.18]
117034912  MYLK3; myosin light chain kinase 3 isoform X1 [KO:K00907] [EC:2.7.11.18]
117016156  MYLK2; myosin light chain kinase 2, skeletal/cardiac muscle [KO:K00907] [EC:2.7.11.18]
117019169  CAMK1D; calcium/calmodulin-dependent protein kinase type 1D isoform X1 [KO:K08794] [EC:2.7.11.17]
117014256  CAMK1G; LOW QUALITY PROTEIN: calcium/calmodulin-dependent protein kinase type 1G [KO:K08794] [EC:2.7.11.17]
117036636  CAMK1; calcium/calmodulin-dependent protein kinase type 1 isoform X1 [KO:K08794] [EC:2.7.11.17]
117012276  CAMK2B; calcium/calmodulin-dependent protein kinase type II subunit beta isoform X1 [KO:K04515] [EC:2.7.11.17]
117035828  CAMK2G; calcium/calmodulin-dependent protein kinase type II subunit gamma isoform X1 [KO:K04515] [EC:2.7.11.17]
117016683  CAMK2A; calcium/calmodulin-dependent protein kinase type II subunit alpha isoform X1 [KO:K04515] [EC:2.7.11.17]
117038075  CAMK2D; LOW QUALITY PROTEIN: calcium/calmodulin-dependent protein kinase type II subunit delta [KO:K04515] [EC:2.7.11.17]
117024996  CAMK4; calcium/calmodulin-dependent protein kinase type IV [KO:K05869] [EC:2.7.11.17]
117035970  PPP3CB; LOW QUALITY PROTEIN: serine/threonine-protein phosphatase 2B catalytic subunit beta isoform [KO:K04348] [EC:3.1.3.16]
117022051  PPP3CA; serine/threonine-protein phosphatase 2B catalytic subunit alpha isoform isoform X1 [KO:K04348] [EC:3.1.3.16]
117037738  PPP3CC; serine/threonine-protein phosphatase 2B catalytic subunit gamma isoform isoform X1 [KO:K04348] [EC:3.1.3.16]
117032505  PPP3R2; calcineurin subunit B type 2 [KO:K06268]
117033213  PPP3R1; calcineurin subunit B type 1 isoform X1 [KO:K06268]
117020438  TFEB; transcription factor EB isoform X1 [KO:K15590]
117011750  NFATC1; nuclear factor of activated T-cells, cytoplasmic 1 isoform X1 [KO:K04446]
117016044  NFATC2; nuclear factor of activated T-cells, cytoplasmic 2 isoform X1 [KO:K17332]
117035268  NFATC3; nuclear factor of activated T-cells, cytoplasmic 3 isoform X1 [KO:K17333]
117024004  NFATC4; nuclear factor of activated T-cells, cytoplasmic 4 isoform X1 [KO:K17334]
117017522  NOS1; nitric oxide synthase, brain isoform X1 [KO:K13240] [EC:1.14.13.39]
117012675  NOS2; nitric oxide synthase, inducible [KO:K13241] [EC:1.14.13.39]
117018217  NOS3; nitric oxide synthase, endothelial [KO:K13242] [EC:1.14.13.39]
117026129  PDE1A; calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A isoform X1 [KO:K13755] [EC:3.1.4.17]
117012389  PDE1C; calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1C isoform X1 [KO:K13755] [EC:3.1.4.17]
117028618  PDE1B; calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1B isoform X1 [KO:K13755] [EC:3.1.4.17]
117037602  PTK2B; protein-tyrosine kinase 2-beta isoform X1 [KO:K05871] [EC:2.7.10.2]
117018603  ITPKB; inositol-trisphosphate 3-kinase B [KO:K00911] [EC:2.7.1.127]
117035071  ITPKC; inositol-trisphosphate 3-kinase C [KO:K00911] [EC:2.7.1.127]
117024209  ITPKA; inositol-trisphosphate 3-kinase A isoform X1 [KO:K00911] [EC:2.7.1.127]
117012818  PRKCA; protein kinase C alpha type isoform X1 [KO:K02677] [EC:2.7.11.13]
117019414  PRKCB; protein kinase C beta type isoform X1 [KO:K19662] [EC:2.7.11.13]
117035150  PRKCG; protein kinase C gamma type [KO:K19663] [EC:2.7.11.13]
Compound
C00002  ATP
C00004  NADH
C00076  Calcium cation
C00165  Diacylglycerol
C00575  3',5'-Cyclic AMP
C01245  D-myo-Inositol 1,4,5-trisphosphate
C01330  Sodium cation
C06124  Sphingosine 1-phosphate
C11556  1-Phosphatidyl-1D-myo-inositol 3,5-bisphosphate
C13050  Cyclic ADP-ribose
C13051  Nicotinic acid adenine dinucleotide phosphate
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Nat Rev Mol Cell Biol 4:517-29 (2003)
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Ann N Y Acad Sci 1238:74-90 (2011)
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Giachini FR, Lima VV, Hannan JL, Carneiro FS, Webb RC, Tostes RC
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STIM1/Orai1-mediated store-operated Ca2+ entry: the tip of the iceberg.
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Reference
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The acid test: the discovery of two-pore channels (TPCs) as NAADP-gated endolysosomal Ca(2+) release channels.
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Pflugers Arch 458:869-76 (2009)
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Reference
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Ca(2+) signaling in striated muscle: the elusive roles of triadin, junctin, and calsequestrin.
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Eur Biophys J 39:27-36 (2009)
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Reference
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Marty I
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Triadin regulation of the ryanodine receptor complex.
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J Physiol 593:3261-6 (2015)
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Reference
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Arvanitis DA, Vafiadaki E, Sanoudou D, Kranias EG
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Histidine-rich calcium binding protein: the new regulator of sarcoplasmic reticulum calcium cycling.
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Related
pathway
rfq04010  MAPK signaling pathway
rfq04070  Phosphatidylinositol signaling system
rfq04210  Apoptosis
rfq04720  Long-term potentiation
rfq04730  Long-term depression
KO pathway
ko04020   
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