KEGG   PATHWAY: stru04620
Entry
stru04620                   Pathway                                
Name
Toll-like receptor signaling pathway - Salmo trutta (river trout)
Description
Specific families of pattern recognition receptors are responsible for detecting microbial pathogens and generating innate immune responses. Toll-like receptors (TLRs) are membrane-bound receptors identified as homologs of Toll in Drosophila. Mammalian TLRs are expressed on innate immune cells, such as macrophages and dendritic cells, and respond to the membrane components of Gram-positive or Gram-negative bacteria. Pathogen recognition by TLRs provokes rapid activation of innate immunity by inducing production of proinflammatory cytokines and upregulation of costimulatory molecules. TLR signaling pathways are separated into two groups: a MyD88-dependent pathway that leads to the production of proinflammatory cytokines with quick activation of NF-{kappa}B and MAPK, and a MyD88-independent pathway associated with the induction of IFN-beta and IFN-inducible genes, and maturation of dendritic cells with slow activation of NF-{kappa}B and MAPK.
Class
Organismal Systems; Immune system
Pathway map
stru04620  Toll-like receptor signaling pathway
stru04620

Organism
Salmo trutta (river trout) [GN:stru]
Gene
115173421  toll-like receptor 6 [KO:K05398]
115176782  toll-like receptor 2 type-2 [KO:K10159]
115178865  toll-like receptor 2 type-1 [KO:K10159]
115198035  toll-like receptor 2 [KO:K10159]
115168332  lipopolysaccharide-binding protein-like [KO:K05399]
115191901  tlr3; toll-like receptor 3 [KO:K05401]
115174711  tlr5; toll-like receptor 5 [KO:K10168]
115165433  toll-like receptor 5 [KO:K10168]
115168543  toll-like receptor 7 [KO:K05404]
115161349  tlr7; toll-like receptor 7 [KO:K05404]
115159772  toll-like receptor 8 [KO:K10170]
115155958  tlr8; toll-like receptor 8 [KO:K10170]
115161350  toll-like receptor 8 [KO:K10170]
115202582  toll-like receptor 8 [KO:K10170]
115176788  cathepsin K-like [KO:K01371] [EC:3.4.22.38]
115178886  cathepsin K-like [KO:K01371] [EC:3.4.22.38]
115152908  ras-related C3 botulinum toxin substrate 1 [KO:K04392]
115171654  ras-related C3 botulinum toxin substrate 1-like isoform X1 [KO:K04392]
115201416  ras-related C3 botulinum toxin substrate 1 [KO:K04392]
115205281  ras-related C3 botulinum toxin substrate 1-like isoform X1 [KO:K04392]
115170061  phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform-like [KO:K00922] [EC:2.7.1.153]
115158422  pik3ca; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform isoform X1 [KO:K00922] [EC:2.7.1.153]
115165908  pik3cd; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform isoform X1 [KO:K00922] [EC:2.7.1.153]
115163651  phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform-like [KO:K00922] [EC:2.7.1.153]
115156658  phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform-like [KO:K00922] [EC:2.7.1.153]
115206538  phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform-like isoform X1 [KO:K00922] [EC:2.7.1.153]
115192204  phosphatidylinositol 3-kinase regulatory subunit gamma isoform X1 [KO:K02649]
115169527  phosphatidylinositol 3-kinase regulatory subunit gamma-like isoform X1 [KO:K02649]
115158103  phosphatidylinositol 3-kinase regulatory subunit gamma-like isoform X1 [KO:K02649]
115169950  phosphatidylinositol 3-kinase regulatory subunit gamma-like [KO:K02649]
115158753  phosphatidylinositol 3-kinase regulatory subunit gamma-like [KO:K02649]
115159695  phosphatidylinositol 3-kinase regulatory subunit alpha isoform X1 [KO:K02649]
115156743  phosphatidylinositol 3-kinase regulatory subunit gamma-like [KO:K02649]
115167650  phosphatidylinositol 3-kinase regulatory subunit alpha-like [KO:K02649]
115157257  phosphatidylinositol 3-kinase regulatory subunit gamma-like isoform X1 [KO:K02649]
115151679  phosphatidylinositol 3-kinase regulatory subunit gamma-like isoform X1 [KO:K02649]
115203963  phosphatidylinositol 3-kinase regulatory subunit alpha-like isoform X1 [KO:K02649]
115191758  RAC-alpha serine/threonine-protein kinase isoform X1 [KO:K04456] [EC:2.7.11.1]
115174699  RAC-alpha serine/threonine-protein kinase isoform X1 [KO:K04456] [EC:2.7.11.1]
115162386  RAC-alpha serine/threonine-protein kinase-like isoform X1 [KO:K04456] [EC:2.7.11.1]
115154910  RAC-beta serine/threonine-protein kinase-like [KO:K04456] [EC:2.7.11.1]
115163684  RAC-beta serine/threonine-protein kinase-like [KO:K04456] [EC:2.7.11.1]
115178760  RAC-gamma serine/threonine-protein kinase-like [KO:K04456] [EC:2.7.11.1]
115172667  RAC-alpha serine/threonine-protein kinase-like [KO:K04456] [EC:2.7.11.1]
115206563  RAC-beta serine/threonine-protein kinase [KO:K04456] [EC:2.7.11.1]
115201509  RAC-gamma serine/threonine-protein kinase isoform X1 [KO:K04456] [EC:2.7.11.1]
115208587  RAC-gamma serine/threonine-protein kinase-like [KO:K04456] [EC:2.7.11.1]
115204542  RAC-beta serine/threonine-protein kinase-like isoform X1 [KO:K04456] [EC:2.7.11.1]
115167142  toll-interacting protein-like [KO:K05402]
115203188  toll-interacting protein [KO:K05402]
115195308  myd88; myeloid differentiation primary response protein MyD88 [KO:K04729]
115163545  toll/interleukin-1 receptor domain-containing adapter protein-like isoform X1 [KO:K05403]
115167502  FAS-associated death domain protein-like [KO:K02373]
115202892  FAS-associated death domain protein-like [KO:K02373]
115169467  caspase-8-like [KO:K04398] [EC:3.4.22.61]
115155490  caspase-8-like isoform X1 [KO:K04398] [EC:3.4.22.61]
115160794  caspase-8-like [KO:K04398] [EC:3.4.22.61]
115157338  caspase-8-like [KO:K04398] [EC:3.4.22.61]
115196945  irak4; interleukin-1 receptor-associated kinase 4 isoform X1 [KO:K04733] [EC:2.7.11.1]
115168732  irak1; interleukin-1 receptor-associated kinase 1 isoform X1 [KO:K04730] [EC:2.7.11.1]
115166780  TNF receptor-associated factor 6-like [KO:K03175] [EC:2.3.2.27]
115203637  TNF receptor-associated factor 6-like [KO:K03175] [EC:2.3.2.27]
115178837  TGF-beta-activated kinase 1 and MAP3K7-binding protein 1-like [KO:K04403]
115147443  TGF-beta-activated kinase 1 and MAP3K7-binding protein 1-like [KO:K04403]
115194003  TGF-beta-activated kinase 1 and MAP3K7-binding protein 2-like isoform X1 [KO:K04404]
115174890  TGF-beta-activated kinase 1 and MAP3K7-binding protein 2-like isoform X1 [KO:K04404]
115174914  mitogen-activated protein kinase kinase kinase 7-like isoform X1 [KO:K04427] [EC:2.7.11.25]
115162495  mitogen-activated protein kinase kinase kinase 7-like [KO:K04427] [EC:2.7.11.25]
115172787  mitogen-activated protein kinase kinase kinase 7-like [KO:K04427] [EC:2.7.11.25]
115194264  map3k7; mitogen-activated protein kinase kinase kinase 7 isoform X1 [KO:K04427] [EC:2.7.11.25]
115168741  NF-kappa-B essential modulator-like [KO:K07210]
115165245  ikbkg; NF-kappa-B essential modulator isoform X1 [KO:K07210]
115158948  inhibitor of nuclear factor kappa-B kinase subunit alpha-like [KO:K04467] [EC:2.7.11.10]
115162780  inhibitor of nuclear factor kappa-B kinase subunit alpha-like isoform X1 [KO:K04467] [EC:2.7.11.10]
115201018  inhibitor of nuclear factor kappa-B kinase subunit alpha-like [KO:K04467] [EC:2.7.11.10]
115200286  ikbkb; inhibitor of nuclear factor kappa-B kinase subunit beta [KO:K07209] [EC:2.7.11.10]
115174991  NF-kappa-B inhibitor alpha-like [KO:K04734]
115162129  NF-kappa-B inhibitor alpha-like [KO:K04734]
115172401  NF-kappa-B inhibitor alpha-like [KO:K04734]
115196043  NF-kappa-B inhibitor alpha-like [KO:K04734]
115173310  nuclear factor NF-kappa-B p105 subunit-like isoform X1 [KO:K02580]
115205318  nuclear factor NF-kappa-B p105 subunit-like isoform X1 [KO:K02580]
115194158  transcription factor p65-like isoform X1 [KO:K04735]
115198165  putative transcription factor p65 homolog [KO:K04735]
115153850  mitogen-activated protein kinase kinase kinase 8-like [KO:K04415] [EC:2.7.11.25]
115195881  mitogen-activated protein kinase kinase kinase 8-like [KO:K04415] [EC:2.7.11.25]
115192967  map2k1; dual specificity mitogen-activated protein kinase kinase 1 [KO:K04368] [EC:2.7.12.2]
115192626  dual specificity mitogen-activated protein kinase kinase 2-like [KO:K04369] [EC:2.7.12.2]
115169411  dual specificity mitogen-activated protein kinase kinase 2-like [KO:K04369] [EC:2.7.12.2]
115158253  dual specificity mitogen-activated protein kinase kinase 2 [KO:K04369] [EC:2.7.12.2]
115157409  dual specificity mitogen-activated protein kinase kinase 2-like [KO:K04369] [EC:2.7.12.2]
115165075  mitogen-activated protein kinase 1 [KO:K04371] [EC:2.7.11.24]
115192138  mitogen-activated protein kinase 1-like [KO:K04371] [EC:2.7.11.24]
115170800  mitogen-activated protein kinase 1-like [KO:K04371] [EC:2.7.11.24]
115200671  mitogen-activated protein kinase 1-like [KO:K04371] [EC:2.7.11.24]
115153520  dual specificity mitogen-activated protein kinase kinase 6 [KO:K04433] [EC:2.7.12.2]
115171844  dual specificity mitogen-activated protein kinase kinase 6 [KO:K04433] [EC:2.7.12.2]
115201695  dual specificity mitogen-activated protein kinase kinase 6-like [KO:K04433] [EC:2.7.12.2]
115207531  dual specificity mitogen-activated protein kinase kinase 6-like [KO:K04433] [EC:2.7.12.2]
115171440  dual specificity mitogen-activated protein kinase kinase 4-like isoform X1 [KO:K04430] [EC:2.7.12.2]
115156176  dual specificity mitogen-activated protein kinase kinase 4-like [KO:K04430] [EC:2.7.12.2]
115201273  dual specificity mitogen-activated protein kinase kinase 4-like isoform X1 [KO:K04430] [EC:2.7.12.2]
115202704  dual specificity mitogen-activated protein kinase kinase 4-like isoform X1 [KO:K04430] [EC:2.7.12.2]
115178289  dual specificity mitogen-activated protein kinase kinase 7-like isoform X1 [KO:K04431] [EC:2.7.12.2]
115208730  dual specificity mitogen-activated protein kinase kinase 7-like isoform X1 [KO:K04431] [EC:2.7.12.2]
115152195  mitogen-activated protein kinase 12-like [KO:K04441] [EC:2.7.11.24]
115180302  mitogen-activated protein kinase 11-like isoform X1 [KO:K04441] [EC:2.7.11.24]
115180375  mitogen-activated protein kinase 12-like [KO:K04441] [EC:2.7.11.24]
115169006  mitogen-activated protein kinase 14A-like isoform X1 [KO:K04441] [EC:2.7.11.24]
115169019  mitogen-activated protein kinase 14A isoform X1 [KO:K04441] [EC:2.7.11.24]
115165421  mitogen-activated protein kinase 14A-like [KO:K04441] [EC:2.7.11.24]
115165434  mitogen-activated protein kinase 14A-like isoform X1 [KO:K04441] [EC:2.7.11.24]
115166089  mitogen-activated protein kinase 13-like [KO:K04441] [EC:2.7.11.24]
115151057  mitogen-activated protein kinase 14A-like [KO:K04441] [EC:2.7.11.24]
115207356  mitogen-activated protein kinase 14A-like isoform X1 [KO:K04441] [EC:2.7.11.24]
115197396  mitogen-activated protein kinase 12-like isoform X1 [KO:K04441] [EC:2.7.11.24]
115198903  mitogen-activated protein kinase 11-like [KO:K04441] [EC:2.7.11.24]
115198904  mitogen-activated protein kinase 12-like isoform X1 [KO:K04441] [EC:2.7.11.24]
115194041  mitogen-activated protein kinase 8-like isoform X1 [KO:K04440] [EC:2.7.11.24]
115157756  mitogen-activated protein kinase 8 isoform X1 [KO:K04440] [EC:2.7.11.24]
115174527  mitogen-activated protein kinase 9-like isoform X1 [KO:K04440] [EC:2.7.11.24]
115152965  mitogen-activated protein kinase 8-like isoform X1 [KO:K04440] [EC:2.7.11.24]
115159070  mitogen-activated protein kinase 10-like isoform X1 [KO:K04440] [EC:2.7.11.24]
115149487  mitogen-activated protein kinase 10 isoform X1 [KO:K04440] [EC:2.7.11.24]
115201108  mitogen-activated protein kinase 8-like isoform X1 [KO:K04440] [EC:2.7.11.24]
115204538  mitogen-activated protein kinase 9-like [KO:K04440] [EC:2.7.11.24]
115192441  transcription factor AP-1-like [KO:K04448]
115169534  transcription factor AP-1-like [KO:K04448]
115158459  transcription factor AP-1-like [KO:K04448]
115157247  transcription factor AP-1-like [KO:K04448]
115149542  transcription factor AP-1-like [KO:K04448]
115160168  transcription factor AP-1-like [KO:K04448]
115175159  proto-oncogene c-Fos-like [KO:K04379]
115175160  proto-oncogene c-Fos-like [KO:K04379]
115162327  proto-oncogene c-Fos-like isoform X1 [KO:K04379]
115172608  proto-oncogene c-Fos-like isoform X1 [KO:K04379]
115147345  proto-oncogene c-Fos-like [KO:K04379]
115151505  proto-oncogene c-Fos-like [KO:K04379]
115174125  tumor necrosis factor-like [KO:K03156]
115175311  tumor necrosis factor-like [KO:K03156]
115164103  interleukin-1 beta [KO:K04519]
115200532  il1b; interleukin-1 beta [KO:K04519]
115203800  interleukin-1 beta-like [KO:K04519]
115173233  interleukin-6-like [KO:K05405]
115175363  interleukin-6 [KO:K05405]
115162812  uncharacterized protein LOC115162812 [KO:K05406]
115169258  interleukin-12 subunit alpha-like [KO:K05406]
115153954  interleukin-12 subunit beta-like isoform X1 [KO:K05425]
115163975  interleukin-12 subunit beta-like [KO:K05425]
115167701  interleukin-12 subunit beta-like [KO:K05425]
115148491  interleukin-12 subunit beta-like [KO:K05425]
115205629  interleukin-12 subunit beta-like [KO:K05425]
115170621  permeability factor 2-like [KO:K10030]
115162898  interleukin-8-like [KO:K10030]
115171360  permeability factor 2-like [KO:K10030]
115201607  interleukin-8-like [KO:K10030]
115201616  interleukin-8-like [KO:K10030]
115192721  TIR domain-containing adapter molecule 1-like [KO:K05842]
115169632  receptor-interacting serine/threonine-protein kinase 1-like isoform X1 [KO:K02861] [EC:2.7.11.1]
115157139  ripk1; receptor-interacting serine/threonine-protein kinase 1 [KO:K02861] [EC:2.7.11.1]
115180513  interferon regulatory factor 5-like isoform X1 [KO:K09446]
115198674  interferon regulatory factor 6-like isoform X1 [KO:K09446]
115152118  interferon regulatory factor 7-like [KO:K09447]
115197304  interferon regulatory factor 3-like [KO:K09447]
115207524  inhibitor of nuclear factor kappa-B kinase subunit epsilon-like [KO:K07211] [EC:2.7.11.10]
115189789  serine/threonine-protein kinase TBK1-like [KO:K05410] [EC:2.7.11.10]
115189827  serine/threonine-protein kinase TBK1-like isoform X1 [KO:K05410] [EC:2.7.11.10]
115162102  TNF receptor-associated factor 3-like [KO:K03174]
115172380  TNF receptor-associated factor 3-like [KO:K03174]
115162648  interferon regulatory factor 3-like isoform X1 [KO:K05411]
115165602  tumor necrosis factor receptor superfamily member 5-like [KO:K03160]
115167949  tumor necrosis factor receptor superfamily member 5-like [KO:K03160]
115193436  interferon alpha-6-like [KO:K05414]
115170596  interferon beta-like [KO:K05414]
115170660  interferon a3-like [KO:K05414]
115170661  interferon beta-like [KO:K05414]
115170951  interferon a3-like isoform X1 [KO:K05414]
115170955  interferon a3-like isoform X1 [KO:K05414]
115170956  interferon a3-like isoform X1 [KO:K05414]
115170959  interferon a3-like isoform X1 [KO:K05414]
115170960  interferon a3-like isoform X1 [KO:K05414]
115170963  interferon a3-like isoform X1 [KO:K05414]
115170964  interferon a3-like isoform X1 [KO:K05414]
115170966  interferon a3-like [KO:K05414]
115170969  interferon a3-like isoform X1 [KO:K05414]
115170970  interferon a3-like [KO:K05414]
115170971  interferon a3 [KO:K05414]
115196524  interferon alpha-6-like [KO:K05414]
115161438  interferon a3-like isoform X1 [KO:K05414]
115170597  interferon a3-like [KO:K05414]
115170598  interferon a3-like [KO:K05414]
115170662  interferon a3-like [KO:K05414]
115170663  interferon a3-like [KO:K05414]
115170950  interferon a3-like [KO:K05414]
115170952  interferon a3-like [KO:K05414]
115170965  interferon tau-10-like [KO:K05414]
115170967  interferon a3-like [KO:K05414]
115170974  interferon epsilon-like [KO:K05414]
115196551  interferon a3-like [KO:K05414]
115161377  interleukin-10 receptor subunit beta-like [KO:K05131]
115192234  tyrosine-protein kinase JAK1-like isoform X1 [KO:K11217] [EC:2.7.10.2]
115170097  tyrosine-protein kinase JAK1-like isoform X1 [KO:K11217] [EC:2.7.10.2]
115158720  jak1; tyrosine-protein kinase JAK1 [KO:K11217] [EC:2.7.10.2]
115156625  tyrosine-protein kinase JAK1-like [KO:K11217] [EC:2.7.10.2]
115171238  non-receptor tyrosine-protein kinase TYK2-like [KO:K11219] [EC:2.7.10.2]
115199167  non-receptor tyrosine-protein kinase TYK2-like isoform X1 [KO:K11219] [EC:2.7.10.2]
115156118  signal transducer and activator of transcription 1-alpha/beta-like [KO:K11220]
115160666  signal transducer and activator of transcription 1-alpha/beta-like isoform X1 [KO:K11220]
115195984  signal transducer and activator of transcription 1-alpha/beta-like isoform X1 [KO:K11220]
115207827  signal transducer and activator of transcription 1-alpha/beta-like isoform X1 [KO:K11221]
115150804  interferon regulatory factor 8-like [KO:K04693]
115195519  interferon regulatory factor 4-like isoform X1 [KO:K04693]
115194050  C-X-C motif chemokine 9-like [KO:K05416]
115200590  C-X-C motif chemokine 11-1-like [KO:K12672]
115200591  C-X-C motif chemokine 11-1-like [KO:K12672]
115200592  C-X-C motif chemokine 11-1-like [KO:K12672]
115200593  C-X-C motif chemokine 11-1-like [KO:K12672]
115200594  C-X-C motif chemokine 11-1-like [KO:K12672]
115200595  C-X-C motif chemokine 11-1-like [KO:K12672]
115200596  C-X-C motif chemokine 11-1-like [KO:K12672]
115200597  C-X-C motif chemokine 11-1-like [KO:K12672]
115200598  C-X-C motif chemokine 11-1-like [KO:K12672]
115199649  C-X-C motif chemokine 11-1-like [KO:K12672]
Reference
PMID:17275323
  Authors
Kawai T, Akira S.
  Title
TLR signaling.
  Journal
Semin Immunol 19:24-32 (2007)
DOI:10.1016/j.smim.2006.12.004
Reference
PMID:17457343
  Authors
O'Neill LA, Bowie AG.
  Title
The family of five: TIR-domain-containing adaptors in Toll-like receptor signalling.
  Journal
Nat Rev Immunol 7:353-64 (2007)
DOI:10.1038/nri2079
Reference
PMID:16932750
  Authors
Honda K, Taniguchi T.
  Title
IRFs: master regulators of signalling by Toll-like receptors and cytosolic pattern-recognition receptors.
  Journal
Nat Rev Immunol 6:644-58 (2006)
DOI:10.1038/nri1900
Reference
PMID:17395581
  Authors
Uematsu S, Akira S.
  Title
Toll-like receptors and Type I interferons.
  Journal
J Biol Chem 282:15319-23 (2007)
DOI:10.1074/jbc.R700009200
Reference
PMID:16497588
  Authors
Akira S, Uematsu S, Takeuchi O.
  Title
Pathogen recognition and innate immunity.
  Journal
Cell 124:783-801 (2006)
DOI:10.1016/j.cell.2006.02.015
Reference
PMID:14698224
  Authors
Yamamoto M, Takeda K, Akira S.
  Title
TIR domain-containing adaptors define the specificity of TLR signaling.
  Journal
Mol Immunol 40:861-8 (2004)
DOI:10.1016/j.molimm.2003.10.006
Reference
PMID:12734364
  Authors
Means TK, Hayashi F, Smith KD, Aderem A, Luster AD.
  Title
The Toll-like receptor 5 stimulus bacterial flagellin induces maturation and chemokine production in human dendritic cells.
  Journal
J Immunol 170:5165-75 (2003)
DOI:10.4049/jimmunol.170.10.5165
Reference
PMID:14751764
  Authors
Aderem A, Smith KD.
  Title
A systems approach to dissecting immunity and inflammation.
  Journal
Semin Immunol 16:55-67 (2004)
DOI:10.1016/j.smim.2003.10.002
Reference
PMID:17637696
  Authors
Banerjee A, Gerondakis S.
  Title
Coordinating TLR-activated signaling pathways in cells of the immune system.
  Journal
Immunol Cell Biol 85:420-4 (2007)
DOI:10.1038/sj.icb.7100098
Reference
PMID:17507094
  Authors
Loniewski KJ, Patial S, Parameswaran N.
  Title
Sensitivity of TLR4- and -7-induced NF kappa B1 p105-TPL2-ERK pathway to TNF-receptor-associated-factor-6 revealed by RNAi in mouse macrophages.
  Journal
Mol Immunol 44:3715-23 (2007)
DOI:10.1016/j.molimm.2007.04.002
Reference
PMID:11101877
  Authors
Arbibe L, Mira JP, Teusch N, Kline L, Guha M, Mackman N, Godowski PJ, Ulevitch RJ, Knaus UG.
  Title
Toll-like receptor 2-mediated NF-kappa B activation requires a Rac1-dependent pathway.
  Journal
Nat Immunol 1:533-40 (2000)
DOI:10.1038/82797
Reference
PMID:16924467
  Authors
Uematsu S, Akira S.
  Title
Toll-like receptors and innate immunity.
  Journal
J Mol Med 84:712-25 (2006)
DOI:10.1007/s00109-006-0084-y
Related
pathway
stru04010  MAPK signaling pathway
stru04060  Cytokine-cytokine receptor interaction
stru04120  Ubiquitin mediated proteolysis
stru04210  Apoptosis
KO pathway
ko04620   
LinkDB

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