KEGG   PATHWAY: trn04060
Entry
trn04060                    Pathway                                
Name
Cytokine-cytokine receptor interaction - Trichomycterus rosablanca
Description
Cytokines are soluble extracellular proteins or glycoproteins that are crucial intercellular regulators and mobilizers of cells engaged in innate as well as adaptive inflammatory host defenses, cell growth, differentiation, cell death, angiogenesis, and development and repair processes aimed at the restoration of homeostasis. Cytokines are released by various cells in the body, usually in response to an activating stimulus, and they induce responses through binding to specific receptors on the cell surface of target cells. Cytokines can be grouped by structure into different families and their receptors can likewise be grouped.
Class
Environmental Information Processing; Signaling molecules and interaction
Pathway map
trn04060  Cytokine-cytokine receptor interaction
trn04060

Organism
Trichomycterus rosablanca [GN:trn]
Gene
134300317  ngfra; tumor necrosis factor receptor superfamily member 16 [KO:K02583]
134300827  bmp6; bone morphogenetic protein 6 [KO:K16620]
134300867  tnfa; tumor necrosis factor a (TNF superfamily, member 2) [KO:K03156]
134300955  tnfsf10; tumor necrosis factor ligand superfamily member 10 [KO:K04721]
134301071  ccr9b; C-C chemokine receptor type 9 [KO:K04184]
134301088  ccl20b; C-C motif chemokine 20b [KO:K14625]
134301214  tnfrsf11a; tumor necrosis factor receptor superfamily member 11A [KO:K05147]
134301226  [KO:K05075]
134301243  ackr4b; atypical chemokine receptor 4b [KO:K04186]
134301439  bmp7a; bone morphogenetic protein 7a [KO:K16621]
134301446  il17rc; uncharacterized protein il17rc [KO:K05166]
134301472  gdf6b; growth/differentiation factor 6-B [KO:K20012]
134301525  il6; interleukin-6 [KO:K05405]
134301617  [KO:K05477]
134301619  il10; interleukin-10 [KO:K05443]
134301624  [KO:K05477]
134301647  [KO:K05414]
134301662  [KO:K05414]
134301672  [KO:K05414]
134301682  [KO:K05414]
134301915  il2rb; interleukin-2 receptor subunit beta [KO:K05069]
134302070  tnfrsf9b; tumor necrosis factor receptor superfamily member 9b [KO:K05146]
134302105  [KO:K22679]
134302129  tnfrsf1b; tumor necrosis factor receptor superfamily member 1B [KO:K05141]
134302147  il19l; interleukin 19 like [KO:K22667]
134302199  [KO:K05504]
134302212  [KO:K14625]
134302241  [KO:K04193]
134302242  xcr1b.2; chemokine XC receptor 1 [KO:K04193]
134302250  crfb16; cytokine receptor family member B16 [KO:K05137]
134302353  [KO:K13596] [EC:2.7.11.30]
134302488  inhbab; inhibin subunit beta Ab [KO:K04667]
134302490  tgfb1a; transforming growth factor, beta 1a [KO:K13375]
134302542  thpo; thrombopoietin [KO:K06854]
134302751  admp; anti-dorsalizing morphogenic protein [KO:K21283]
134302795  ccl25a; C-C motif chemokine 21 [KO:K13072]
134302828  il12a; interleukin-12 subunit alpha [KO:K05406]
134302896  [KO:K14625]
134303398  eda; ectodysplasin-A isoform X1 [KO:K05480]
134303455  tnfsf13; tumor necrosis factor ligand superfamily member 13 isoform X1 [KO:K05475]
134303501  il13ra2; interleukin-13 receptor subunit alpha-2 [KO:K05077]
134303670  eda2r; tumor necrosis factor receptor superfamily member 27 [KO:K05163]
134303691  [KO:K22629]
134304076  cxcl12b; chemokine (C-X-C motif) ligand 12b (stromal cell-derived factor 1) [KO:K10031]
134304240  mstna; myostatin a [KO:K05497]
134308099  [KO:K04665]
134308687  bmp8a; bone morphogenetic protein 8A [KO:K16622]
134309219  [KO:K05414]
134309840  tgfbr1b; TGF-beta receptor type-1b [KO:K04674] [EC:2.7.11.30]
134309905  tgfbr2b; TGF-beta receptor type-2 [KO:K04388] [EC:2.7.11.30]
134310072  [KO:K05143]
134310076  [KO:K04180]
134310077  [KO:K04180]
134310078  [KO:K04180]
134310088  cd4-1; CD4-1 molecule [KO:K06454]
134310089  [KO:K04188]
134310090  [KO:K04188]
134310223  il11a; uncharacterized protein il11a [KO:K05417]
134310244  nradd; tumor necrosis factor receptor superfamily member 16 [KO:K02583]
134310266  [KO:K05148]
134310305  cxcr3.1; C-X-C chemokine receptor type 3.1 [KO:K04188]
134310307  [KO:K04188]
134310452  inhbaa; inhibin subunit beta Aa [KO:K04667]
134310470  acvr2ba; activin receptor type-2B [KO:K13596] [EC:2.7.11.30]
134310515  gdf6a; growth/differentiation factor 6-A [KO:K20012]
134310529  tgfb2; transforming growth factor beta-2 proprotein [KO:K13376]
134310552  csf3r; granulocyte colony-stimulating factor receptor [KO:K05061]
134310626  tnfrsf1a; tumor necrosis factor receptor superfamily member 1A [KO:K03158]
134310979  il6r; interleukin-6 receptor subunit alpha isoform X1 [KO:K05055]
134311293  ccl20l; C-C motif chemokine 20 [KO:K14625]
134311297  ebi3; interleukin-27 subunit beta [KO:K24476]
134311343  ackr4a; atypical chemokine receptor 4 [KO:K04186]
134311359  ccr9a; C-C chemokine receptor type 9a [KO:K04184]
134311579  bmp15; bone morphogenetic protein 15 [KO:K05498]
134311592  tnfsf12; tumor necrosis factor ligand superfamily member 12 [KO:K05474]
134311628  rell1; RELT-like protein 1 [KO:K26541]
134311665  epoa; erythropoietin [KO:K05437]
134311719  cxcl8b.3; interleukin-8b.3 [KO:K10030]
134311782  gdf9; growth/differentiation factor 9 [KO:K22673]
134311902  [KO:K05076]
134311946  cxcl19; C-X-C motif chemokine 19 [KO:K10030]
134312020  [KO:K05408]
134312021  [KO:K21092]
134312117  acvr1l; activin receptor type-1 [KO:K04675] [EC:2.7.11.30]
134314405  ifngr1l; interferon gamma receptor 1-like [KO:K05132]
134314564  gdf10a; growth/differentiation factor 10 [KO:K22674]
134314571  cxcl12a; chemokine (C-X-C motif) ligand 12a (stromal cell-derived factor 1) [KO:K10031]
134314705  bmpr1aa; bone morphogenetic protein receptor, type IAa [KO:K04673] [EC:2.7.11.30]
134315001  bmp5; bone morphogenetic protein 5 [KO:K04663]
134315301  il15; interleukin-15 [KO:K05433]
134316265  ngfb; nerve growth factor [KO:K02582]
134316373  gdf5; growth/differentiation factor 5 [KO:K04664]
134316431  inha; inhibin alpha chain [KO:K05500]
134316439  ackr3b; atypical chemokine receptor 3b [KO:K04304]
134316478  cxcr4a; C-X-C chemokine receptor type 4a [KO:K04189]
134316481  bmpr2a; bone morphogenetic protein receptor type-2a [KO:K04671] [EC:2.7.11.30]
134316495  ccr7; C-C chemokine receptor type 7 [KO:K04182]
134316664  il12rb2; interleukin-12 receptor subunit beta-2 [KO:K05064]
134316741  tnfrsf18; tumor necrosis factor receptor superfamily member 18 [KO:K05154]
134316880  [KO:K13567] [EC:2.7.11.30]
134316916  [KO:K22687]
134317090  acvr2ab; activin receptor type-2A isoform X1 [KO:K04670] [EC:2.7.11.30]
134317275  [KO:K05050]
134317302  [KO:K05069]
134317352  mpl; thrombopoietin receptor [KO:K05082]
134317357  lepr; leptin receptor [KO:K05062]
134317977  ccl27a; C-C motif chemokine 27a [KO:K05513]
134318011  [KO:K05152]
134318013  [KO:K05152]
134318026  wu:fl23c11; interleukin-17 receptor C [KO:K05166]
134318027  [KO:K05168]
134318261  [KO:K05152]
134318515  ghra; growth hormone receptor a [KO:K05080]
134318680  il12ba; interleukin 12Ba [KO:K05425]
134318759  [KO:K21095]
134318760  [KO:K05509]
134318803  [KO:K05480]
134318990  cxcl14; C-X-C motif chemokine 14 [KO:K10033]
134319180  clcf1; uncharacterized protein clcf1 [KO:K05421]
134319310  tgfb5; transforming growth factor beta-2 proprotein [KO:K13376]
134319668  il2rgb; interleukin 2 receptor, gamma b [KO:K05070]
134319669  cd40lg; CD40 ligand [KO:K03161]
134319747  [KO:K05090] [EC:2.7.10.1]
134319902  [KO:K05490]
134319952  tnfrsf21; tumor necrosis factor receptor superfamily member 21 [KO:K05157]
134319963  il17a/f3; interleukin 17a/f3 [KO:K05494]
134320004  faslg; tumor necrosis factor ligand superfamily member 6 [KO:K04389]
134320074  bmp2b; bone morphogenetic protein 2b [KO:K21283]
134320524  il20ra; interleukin-20 receptor subunit alpha [KO:K05136]
134320889  ccr6a; C-C chemokine receptor type 6a [KO:K04181]
134321246  bmpr1ab; bone morphogenetic protein receptor, type IAb [KO:K04673] [EC:2.7.11.30]
134321442  [KO:K04388] [EC:2.7.11.30]
134321527  [KO:K05150]
134321565  ndr2; nodal-related 2 [KO:K04666]
134321947  [KO:K05153]
134321998  ngfrb; nerve growth factor receptor b [KO:K02583]
134322152  gdf2; growth/differentiation factor 2 [KO:K05503]
134322153  gdf10b; growth/differentiation factor 10b [KO:K22674]
134322886  lepb; LOW QUALITY PROTEIN: leptin b [KO:K05424]
134323099  bmp16; bone morphogenetic protein 16 [KO:K21283]
134323241  il34; interleukin-34 [KO:K22633]
134323337  lepa; leptin a [KO:K05424]
134323380  smtla; somatolactin alpha [KO:K05438]
134323499  relt; tumor necrosis factor receptor superfamily member 19L [KO:K05156]
134323545  [KO:K04190]
134323858  [KO:K05135]
134323859  [KO:K05131]
134323860  il1rl1; interleukin-1 receptor type 1 [KO:K05171]
134323930  cxcr4b; C-X-C chemokine receptor type 4b [KO:K04189]
134323937  bmpr2b; bone morphogenetic protein receptor type-2 [KO:K04671] [EC:2.7.11.30]
134323938  [KO:K05135]
134323939  il10rb; interleukin-10 receptor subunit beta [KO:K05135]
134323986  acvr2aa; activin receptor type-2A [KO:K04670] [EC:2.7.11.30]
134324022  [KO:K04386]
134324041  edar; tumor necrosis factor receptor superfamily member EDAR [KO:K05162]
134324051  cxcr2; C-X-C chemokine receptor type 2 [KO:K05050]
134324105  [KO:K05135]
134324148  inhbb; inhibin beta B chain [KO:K22687]
134324332  tnfsf13b; tumor necrosis factor ligand superfamily member 13B [KO:K05476]
134324335  il17d; interleukin-17D [KO:K05492]
134324436  zmp:0000000936; interleukin-1 receptor-like 2 isoform X1 [KO:K04386]
134324442  [KO:K04675] [EC:2.7.11.30]
134324443  [KO:K13568] [EC:2.7.11.30]
134324494  [KO:K05050]
134324535  mstnb; growth/differentiation factor 8 [KO:K05497]
134324713  tgfbr2l; TGF-beta receptor type-2 [KO:K04388] [EC:2.7.11.30]
134324861  ccr6b; C-C chemokine receptor type 6 [KO:K04181]
134324912  bmp4; bone morphogenetic protein 4 [KO:K04662]
134324937  bmp2a; bone morphogenetic protein 2 [KO:K21283]
134324984  tgfb3; transforming growth factor beta-3 proprotein isoform X1 [KO:K13377]
134325500  gdf7; growth/differentiation factor 6-A [KO:K20013]
134325714  [KO:K22672]
134325715  [KO:K22672]
134325716  [KO:K22672]
134325719  [KO:K22672]
134325720  [KO:K22672]
134325732  fas; tumor necrosis factor receptor superfamily member 6 isoform X1 [KO:K04390]
134325742  il17a/f1; interleukin 17a/f1 [KO:K05494]
134326105  cxcl8a; C-X-C motif chemokine 2 isoform X1 [KO:K10030]
134326795  il17ra1a; interleukin 17 receptor A1a [KO:K05164]
134327187  ifng1; interferon gamma 1 [KO:K04687]
134327514  il22; interleukin-22 [KO:K05445]
134328510  [KO:K05477]
134329299  [KO:K04386]
134329543  [KO:K05080]
134329588  ifngr1; interferon gamma receptor 1 [KO:K05132]
134330170  tgfb1b; transforming growth factor beta-1 proprotein [KO:K13375]
134330286  lifrb; LIF receptor subunit alpha b isoform X1 [KO:K05058]
134330344  csf1rb; macrophage colony-stimulating factor 1 receptor isoform X1 [KO:K05090] [EC:2.7.10.1]
134330809  prlra; prolactin receptor a [KO:K05081]
134330910  il7r; interleukin-7 receptor subunit alpha [KO:K05072]
134330914  ndr1; nodal-related 1 [KO:K04666]
134331296  amh; muellerian-inhibiting factor [KO:K04665]
134331475  ccl25b; C-C motif chemokine 25b [KO:K13072]
134331478  il16; pro-interleukin-16 [KO:K22628]
134331705  [KO:K22687]
134331890  il12rb1; interleukin-31 receptor subunit alpha [KO:K05063]
134332250  il2rga; interleukin 2 receptor, gamma a [KO:K05070]
134332261  il1b; interleukin-1 beta [KO:K04519]
134332280  il6st; interleukin-6 receptor subunit beta [KO:K05060]
134332347  bmpr1bb; bone morphogenetic protein receptor, type IBb [KO:K13578] [EC:2.7.11.30]
134332417  il11ra; interleukin-11 receptor subunit alpha isoform X1 [KO:K05056]
134332496  cntfr; ciliary neurotrophic factor receptor subunit alpha [KO:K05059]
134332525  [KO:K22670]
134332869  ccl19b; C-C motif chemokine 19b [KO:K05512]
134333079  acvr1ba; activin A receptor type 1Ba [KO:K13567] [EC:2.7.11.30]
134333229  ngfa; neurotrophin-7 [KO:K02582]
134333506  cd40; tumor necrosis factor receptor superfamily member 5 [KO:K03160]
134333851  tnfrsf9a; tumor necrosis factor receptor superfamily member 9a [KO:K05146]
134333901  gh1; somatotropin [KO:K05438]
134333919  [KO:K04193]
134333920  [KO:K04193]
134333921  [KO:K04193]
134334719  [KO:K04723]
134334868  tnfb; tumor necrosis factor b (TNF superfamily, member 2) [KO:K05468]
134334886  tnfrsf19; tumor necrosis factor receptor superfamily member 19 [KO:K05155]
134335217  lifra; LIF receptor subunit alpha a isoform X1 [KO:K05058]
134335369  hdr; hematopoietic death receptor [KO:K04722]
134335405  bmp10; bone morphogenetic protein 10 [KO:K22670]
134335516  bmp3; bone morphogenetic protein 3 [KO:K05496]
134335566  [KO:K10032]
134335742  spaw; southpaw [KO:K04666]
134336257  epor; erythropoietin receptor [KO:K05079]
Reference
PMID:24892271
  Authors
Turner MD, Nedjai B, Hurst T, Pennington DJ
  Title
Cytokines and chemokines: At the crossroads of cell signalling and inflammatory disease.
  Journal
Biochim Biophys Acta 1843:2563-2582 (2014)
DOI:10.1016/j.bbamcr.2014.05.014
Reference
PMID:21106488
  Authors
Brocker C, Thompson D, Matsumoto A, Nebert DW, Vasiliou V
  Title
Evolutionary divergence and functions of the human interleukin (IL) gene family.
  Journal
Hum Genomics 5:30-55 (2010)
DOI:10.1186/1479-7364-5-1-30
Reference
PMID:27577879
  Authors
Akdis M, Aab A, Altunbulakli C, Azkur K, Costa RA, Crameri R, Duan S, Eiwegger T, Eljaszewicz A, Ferstl R, Frei R, Garbani M, Globinska A, Hess L, Huitema C, Kubo T, Komlosi Z, Konieczna P, Kovacs N, Kucuksezer UC, Meyer N, Morita H, Olzhausen J, O'Mahony L, Pezer M, Prati M, Rebane A, Rhyner C, Rinaldi A, Sokolowska M, Stanic B, Sugita K, Treis A, van de Veen W, Wanke K, Wawrzyniak M, Wawrzyniak P, Wirz OF, Zakzuk JS, Akdis CA
  Title
Interleukins (from IL-1 to IL-38), interferons, transforming growth factor beta, and TNF-alpha: Receptors, functions, and roles in diseases.
  Journal
J Allergy Clin Immunol 138:984-1010 (2016)
DOI:10.1016/j.jaci.2016.06.033
Reference
PMID:15500860
  Authors
Boulanger MJ, Garcia KC
  Title
Shared cytokine signaling receptors: structural insights from the gp130 system.
  Journal
Adv Protein Chem 68:107-46 (2004)
DOI:10.1016/S0065-3233(04)68004-1
Reference
PMID:16034365
  Authors
Allan SM, Tyrrell PJ, Rothwell NJ
  Title
Interleukin-1 and neuronal injury.
  Journal
Nat Rev Immunol 5:629-40 (2005)
DOI:10.1038/nri1664
Reference
PMID:23847622
  Authors
Lopetuso LR, Chowdhry S, Pizarro TT
  Title
Opposing Functions of Classic and Novel IL-1 Family Members in Gut Health and Disease.
  Journal
Front Immunol 4:181 (2013)
DOI:10.3389/fimmu.2013.00181
Reference
PMID:21349428
  Authors
Iwakura Y, Ishigame H, Saijo S, Nakae S
  Title
Functional specialization of interleukin-17 family members.
  Journal
Immunity 34:149-62 (2011)
DOI:10.1016/j.immuni.2011.02.012
Reference
PMID:17530315
  Authors
Fischer P, Hilfiker-Kleiner D
  Title
Survival pathways in hypertrophy and heart failure: the gp130-STAT3 axis.
  Journal
Basic Res Cardiol 102:279-97 (2007)
DOI:10.1007/s00395-007-0658-z
Reference
PMID:24381786
  Authors
Richards CD
  Title
The enigmatic cytokine oncostatin m and roles in disease.
  Journal
ISRN Inflamm 2013:512103 (2013)
DOI:10.1155/2013/512103
Reference
PMID:18926762
  Authors
Zhang Q, Putheti P, Zhou Q, Liu Q, Gao W
  Title
Structures and biological functions of IL-31 and IL-31 receptors.
  Journal
Cytokine Growth Factor Rev 19:347-56 (2008)
DOI:10.1016/j.cytogfr.2008.08.003
Reference
PMID:21155715
  Authors
Meenhuis A, Verwijmeren C, Roovers O, Touw IP
  Title
The deubiquitinating enzyme DUB2A enhances CSF3 signalling by attenuating lysosomal routing of the CSF3 receptor.
  Journal
Biochem J 434:343-51 (2011)
DOI:10.1042/BJ20101628
Reference
PMID:22410872
  Authors
de Weerd NA, Nguyen T
  Title
The interferons and their receptors--distribution and regulation.
  Journal
Immunol Cell Biol 90:483-91 (2012)
DOI:10.1038/icb.2012.9
Reference
PMID:12949498
  Authors
Aggarwal BB
  Title
Signalling pathways of the TNF superfamily: a double-edged sword.
  Journal
Nat Rev Immunol 3:745-56 (2003)
DOI:10.1038/nri1184
Reference
PMID:12189384
  Authors
Ashkenazi A
  Title
Targeting death and decoy receptors of the tumour-necrosis factor superfamily.
  Journal
Nat Rev Cancer 2:420-30 (2002)
DOI:10.1038/nrc821
Reference
PMID:26115564
  Authors
Seeger P, Musso T, Sozzani S
  Title
The TGF-beta superfamily in dendritic cell biology.
  Journal
Cytokine Growth Factor Rev 26:647-57 (2015)
DOI:10.1016/j.cytogfr.2015.06.002
Reference
PMID:23612460
  Authors
Wakefield LM, Hill CS
  Title
Beyond TGFbeta: roles of other TGFbeta superfamily members in cancer.
  Journal
Nat Rev Cancer 13:328-41 (2013)
DOI:10.1038/nrc3500
Reference
PMID:22710174
  Authors
Mueller TD, Nickel J
  Title
Promiscuity and specificity in BMP receptor activation.
  Journal
FEBS Lett 586:1846-59 (2012)
DOI:10.1016/j.febslet.2012.02.043
KO pathway
ko04060   

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