KEGG   PATHWAY: tros04060
Entry
tros04060                   Pathway                                
Name
Cytokine-cytokine receptor interaction - Triplophysa rosa
Description
Cytokines are soluble extracellular proteins or glycoproteins that are crucial intercellular regulators and mobilizers of cells engaged in innate as well as adaptive inflammatory host defenses, cell growth, differentiation, cell death, angiogenesis, and development and repair processes aimed at the restoration of homeostasis. Cytokines are released by various cells in the body, usually in response to an activating stimulus, and they induce responses through binding to specific receptors on the cell surface of target cells. Cytokines can be grouped by structure into different families and their receptors can likewise be grouped.
Class
Environmental Information Processing; Signaling molecules and interaction
Pathway map
tros04060  Cytokine-cytokine receptor interaction
tros04060

Organism
Triplophysa rosa [GN:tros]
Gene
130545019  cd40; tumor necrosis factor receptor superfamily member 5 isoform X1 [KO:K03160]
130545199  tnfrsf9a; LOW QUALITY PROTEIN: tumor necrosis factor receptor superfamily member 9a [KO:K05146]
130545223  [KO:K04193]
130545500  ngfa; neurotrophin-7 [KO:K02582]
130545548  [KO:K04193]
130545549  [KO:K04193]
130545695  il2rga; interleukin 2 receptor, gamma a [KO:K05070]
130545717  il1b; interleukin-1 beta [KO:K04519]
130545742  [KO:K22670]
130545784  cntfr; ciliary neurotrophic factor receptor subunit alpha [KO:K05059]
130545905  il6st; interleukin-6 receptor subunit beta [KO:K05060]
130546069  il11ra; interleukin-11 receptor subunit alpha [KO:K05056]
130546176  il13ra2; interleukin-13 receptor subunit alpha-2 [KO:K05077]
130546324  epob; erythropoietin b isoform X1 [KO:K05437]
130546366  ccl19b; C-C motif chemokine 19b [KO:K05512]
130546412  ccl27b; C-C motif chemokine 27b [KO:K05513]
130546850  bmp6; bone morphogenetic protein 6 [KO:K16620]
130546904  ackr4b; atypical chemokine receptor 4b isoform X1 [KO:K04186]
130546913  ccl20b; C-C motif chemokine 20b [KO:K14625]
130546999  ccr9b; C-C chemokine receptor type 9 [KO:K04184]
130547011  inhbaa; inhibin subunit beta Aa [KO:K04667]
130547097  acvr2ba; activin receptor type-2B [KO:K13596] [EC:2.7.11.30]
130547155  tnfsf10; tumor necrosis factor ligand superfamily member 10 [KO:K04721]
130547187  bmpr1ba; bone morphogenetic protein receptor type-1B [KO:K13578] [EC:2.7.11.30]
130547276  tgfbr1b; TGF-beta receptor type-1b [KO:K04674] [EC:2.7.11.30]
130547436  tnfrsf11a; tumor necrosis factor receptor superfamily member 11A isoform X1 [KO:K05147]
130547694  il17ra1a; interleukin 17 receptor A1a [KO:K05164]
130547821  ifng1; interferon gamma 1 [KO:K04687]
130547822  il22; interleukin-22 [KO:K05445]
130547969  eda2r; tumor necrosis factor receptor superfamily member 27 [KO:K05163]
130548125  prl2; prolactin 2 [KO:K05439]
130548161  lepb; leptin b [KO:K05424]
130548312  [KO:K21095]
130548318  [KO:K21095]
130549109  mstna; myostatin a isoform X1 [KO:K05497]
130549193  cxcl12b; chemokine (C-X-C motif) ligand 12b (stromal cell-derived factor 1) [KO:K10031]
130549254  amh; muellerian-inhibiting factor [KO:K04665]
130549418  csf1ra; macrophage colony-stimulating factor 1 receptor [KO:K05090] [EC:2.7.10.1]
130549483  [KO:K21095]
130549987  tgfb2; transforming growth factor beta-2 proprotein [KO:K13376]
130550825  lifra; LIF receptor subunit alpha a [KO:K05058]
130550889  eda; ectodysplasin-A isoform X1 [KO:K05480]
130551147  [KO:K13578] [EC:2.7.11.30]
130551148  [KO:K13578] [EC:2.7.11.30]
130551151  [KO:K13578] [EC:2.7.11.30]
130551212  rell2; RELT-like protein 2 [KO:K26541]
130552177  [KO:K21095]
130552931  [KO:K05477]
130553461  ifngr1; interferon gamma receptor 1 [KO:K05132]
130553472  [KO:K05080]
130553589  cxcl8a; permeability factor 2 [KO:K10030]
130553912  ackr4a; atypical chemokine receptor 4 isoform X1 [KO:K04186]
130553919  acvr1l; activin receptor type-1 [KO:K04675] [EC:2.7.11.30]
130553925  thpo; thrombopoietin isoform X1 [KO:K06854]
130553936  inhbab; inhibin subunit beta Ab [KO:K04667]
130554437  tgfbr1a; TGF-beta receptor type-1a isoform X1 [KO:K04674] [EC:2.7.11.30]
130554503  ccl20l; C-C motif chemokine 20 [KO:K14625]
130554557  tnfsf12; tumor necrosis factor ligand superfamily member 12 [KO:K05474]
130554600  crfb16; cytokine receptor family member B16 isoform X1 [KO:K05137]
130554686  ccr9a; C-C chemokine receptor type 9a [KO:K04184]
130554764  [KO:K04193]
130554766  xcr1b.1; chemokine XC receptor 1 [KO:K04193]
130554792  [KO:K13596] [EC:2.7.11.30]
130554812  admp; anti-dorsalizing morphogenic protein [KO:K21283]
130554815  ccl25a; LOW QUALITY PROTEIN: C-C motif chemokine 21 [KO:K13072]
130554867  [KO:K05504]
130554909  [KO:K05406]
130554915  ebi3; interleukin-27 subunit beta [KO:K24476]
130555067  ccl20a.3; C-C motif chemokine 20a.3 [KO:K14625]
130555219  bmpr2b; bone morphogenetic protein receptor type-2 isoform X1 [KO:K04671] [EC:2.7.11.30]
130555406  edar; tumor necrosis factor receptor superfamily member EDAR isoform X1 [KO:K05162]
130555422  il1rl1; interleukin-1 receptor-like 1 isoform X1 [KO:K05171]
130555423  [KO:K04386]
130555563  il17d; interleukin-17D [KO:K05492]
130555596  mstnb; growth/differentiation factor 8 [KO:K05497]
130555635  tnfsf13b; tumor necrosis factor ligand superfamily member 13B isoform X1 [KO:K05476]
130555641  cxcr4b; C-X-C chemokine receptor type 4b [KO:K04189]
130555673  ackr3a; atypical chemokine receptor 3a [KO:K04304]
130555687  zmp:0000000936; interleukin-1 receptor type 1 [KO:K04386]
130555692  tgfbr2l; TGF-beta receptor type-2 [KO:K04388] [EC:2.7.11.30]
130555845  acvr2aa; activin receptor type-2A isoform X1 [KO:K04670] [EC:2.7.11.30]
130555867  [KO:K05050]
130555868  cxcr2; C-X-C chemokine receptor type 1 [KO:K05050]
130555912  [KO:K13568] [EC:2.7.11.30]
130555957  [KO:K04675] [EC:2.7.11.30]
130556100  il10rb; interleukin-10 receptor subunit beta [KO:K05135]
130556107  crfb4; cytokine receptor family member b4 [KO:K05135]
130556181  inhbb; inhibin beta B chain [KO:K22687]
130556194  crfb2; cytokine receptor family member b2 [KO:K05131]
130556298  bmpr2a; bone morphogenetic protein receptor type-2a [KO:K04671] [EC:2.7.11.30]
130556372  [KO:K05153]
130556443  acvr2ab; activin receptor type-2A isoform X1 [KO:K04670] [EC:2.7.11.30]
130556521  lepr; leptin receptor [KO:K05062]
130556732  ackr3b; atypical chemokine receptor 3b [KO:K04304]
130556773  ccr7; C-C chemokine receptor type 7 [KO:K04182]
130556786  acvr1bb; activin receptor type-1B [KO:K13567] [EC:2.7.11.30]
130556856  tnfrsf18; tumor necrosis factor receptor superfamily member 18 isoform X1 [KO:K05154]
130556867  il12rb2; interleukin-12 receptor subunit beta-2 [KO:K05064]
130556914  gdf5; growth/differentiation factor 5 [KO:K04664]
130557015  ngfb; LOW QUALITY PROTEIN: nerve growth factor [KO:K02582]
130557082  inha; inhibin alpha chain [KO:K05500]
130557144  [KO:K22687]
130557194  mpl; thrombopoietin receptor isoform X1 [KO:K05082]
130557360  cxcr4a; C-X-C chemokine receptor type 4a [KO:K04189]
130557630  rell1; RELT-like protein 1 [KO:K26541]
130557680  [KO:K05148]
130557681  [KO:K05143]
130557739  csf3r; granulocyte colony-stimulating factor receptor [KO:K05061]
130557748  tgfbr2b; TGF-beta receptor type-2 [KO:K04388] [EC:2.7.11.30]
130557943  il6r; interleukin-6 receptor subunit alpha [KO:K05055]
130558186  [KO:K04180]
130558188  gdf6a; growth/differentiation factor 6-A [KO:K20012]
130558465  cd4-1; CD4-1 molecule isoform X1 [KO:K06454]
130558473  cxcr3.2; C-X-C chemokine receptor type 3-2 [KO:K04188]
130558474  cxcr3.3; C-X-C chemokine receptor type 3.3 [KO:K04188]
130558475  cxcr3.1; C-X-C chemokine receptor type 3.1 [KO:K04188]
130558479  [KO:K04188]
130558490  il11a; uncharacterized protein il11a [KO:K05417]
130558505  epoa; erythropoietin isoform X1 [KO:K05437]
130558528  nradd; tumor necrosis factor receptor superfamily member 16 [KO:K02583]
130558643  tnfrsf1a; tumor necrosis factor receptor superfamily member 1A [KO:K03158]
130558645  cd27; uncharacterized protein cd27 isoform X1 [KO:K05144]
130559003  bmp5; bone morphogenetic protein 5 isoform X1 [KO:K04663]
130559139  bmp15; bone morphogenetic protein 15 [KO:K05498]
130559156  gdf10a; growth/differentiation factor 10 [KO:K22674]
130559186  ifngr1l; interferon gamma receptor 1-like [KO:K05132]
130559410  cxcl12a; chemokine (C-X-C motif) ligand 12a (stromal cell-derived factor 1) [KO:K10031]
130559543  [KO:K05416]
130559735  bmpr1aa; bone morphogenetic protein receptor, type IAa isoform X1 [KO:K04673] [EC:2.7.11.30]
130560077  [KO:K10030]
130560082  tgfb3; transforming growth factor beta-3 proprotein [KO:K13377]
130560091  [KO:K10030]
130560101  cxcl19; C-X-C motif chemokine 19 [KO:K10030]
130560256  bmp2a; bone morphogenetic protein 2 [KO:K21283]
130560488  [KO:K04181]
130560534  [KO:K04181]
130560567  gdf3; protein DVR-1 isoform X1 [KO:K22672]
130560705  gdf7; growth/differentiation factor 6-A [KO:K20013]
130560774  il17a/f1; interleukin 17a/f1 [KO:K05494]
130560795  fas; tumor necrosis factor receptor superfamily member 6 [KO:K04390]
130560822  bmp4; bone morphogenetic protein 4 [KO:K04662]
130561164  [KO:K13578] [EC:2.7.11.30]
130561333  gh1; somatotropin [KO:K05438]
130561354  il21r.1; interleukin 21 receptor, tandem duplicate 1 isoform X1 [KO:K05075]
130561495  il2rb; interleukin-2 receptor subunit beta isoform X1 [KO:K05069]
130561570  [KO:K05071]
130561720  ifnphi1; interferon phi 1 isoform X1 [KO:K05414]
130561766  tnfsf14; tumor necrosis factor ligand superfamily member 14 [KO:K05477]
130561905  ifnphi3; interferon phi 3 [KO:K05414]
130561942  epor; erythropoietin receptor [KO:K05079]
130562035  ngfra; tumor necrosis factor receptor superfamily member 16 [KO:K02583]
130562298  csf2rb; cytokine receptor common subunit beta [KO:K04738]
130562472  relt; tumor necrosis factor receptor superfamily member 19L [KO:K05156]
130562621  smtla; somatolactin alpha [KO:K05438]
130562766  [KO:K04190]
130562873  bmp16; bone morphogenetic protein 16 [KO:K21283]
130563000  il34; interleukin-34 [KO:K22633]
130563070  il17c; interleukin-17C [KO:K05491]
130563137  lepa; leptin a [KO:K05424]
130563397  il4; interleukin-4 [KO:K05430]
130563435  tgfb5; transforming growth factor beta-2 proprotein [KO:K13376]
130563507  cd40lg; CD40 ligand [KO:K03161]
130563516  [KO:K05490]
130563731  il21; interleukin-21 [KO:K05434]
130563732  [KO:K05434]
130563889  osmr; leukemia inhibitory factor receptor [KO:K05057]
130564021  il12ba; interleukin 12Ba [KO:K05425]
130564051  gdf9; growth/differentiation factor 9 [KO:K22673]
130564107  clcf1; uncharacterized protein clcf1 [KO:K05421]
130564184  il2rgb; interleukin 2 receptor, gamma b [KO:K05070]
130564255  cxcl14; C-X-C motif chemokine 14 [KO:K10033]
130564574  tgfb1a; transforming growth factor, beta 1a [KO:K13375]
130564586  [KO:K04723]
130564896  tnfrsf19; tumor necrosis factor receptor superfamily member 19 [KO:K05155]
130564920  [KO:K05468]
130564947  tnfb; tumor necrosis factor b (TNF superfamily, member 2) [KO:K05468]
130565029  il12a; interleukin-12 subunit alpha [KO:K05406]
130565336  bmp10; bone morphogenetic protein 10 [KO:K22670]
130565749  faslg; tumor necrosis factor ligand superfamily member 6 [KO:K04389]
130566239  ccr6a; C-C chemokine receptor type 6a [KO:K04181]
130566252  il20ra; interleukin-20 receptor subunit alpha isoform X1 [KO:K05136]
130566305  il17a/f3; interleukin 17a/f3 [KO:K05494]
130566344  tnfrsf21; tumor necrosis factor receptor superfamily member 21 [KO:K05157]
130566405  bmp2b; bone morphogenetic protein 2b [KO:K21283]
130566552  bmp8a; bone morphogenetic protein 8A [KO:K16622]
130566562  il16; pro-interleukin-16 isoform X1 [KO:K22628]
130567035  gdf6b; growth/differentiation factor 6-B [KO:K20012]
130567093  tnfa; tumor necrosis factor a (TNF superfamily, member 2) [KO:K03156]
130567230  il6; interleukin-6 isoform X1 [KO:K05405]
130567379  hdr; hematopoietic death receptor isoform X1 [KO:K04722]
130567657  [KO:K05168]
130568119  [KO:K05080]
130568178  ccl27a; C-C motif chemokine 27a [KO:K05513]
130568324  [KO:K05080]
130568356  [KO:K05165]
130568578  [KO:K12672]
130568589  [KO:K12672]
130568608  [KO:K12672]
130568819  bmpr1ab; bone morphogenetic protein receptor, type IAb [KO:K04673] [EC:2.7.11.30]
130568911  [KO:K05149]
130569189  gdf10b; growth/differentiation factor 10b [KO:K22674]
130569293  ngfrb; nerve growth factor receptor b [KO:K02583]
130569328  [KO:K05153]
130569426  gdf2; growth/differentiation factor 2 [KO:K05503]
130569549  ndr2; nodal-related 2 [KO:K04666]
130569856  ndr1; nodal-related 1 [KO:K04666]
130570044  m17; IL-6 subfamily cytokine M17 isoform X1 [KO:K05420]
130570154  tgfb1b; transforming growth factor beta-1 proprotein [KO:K13375]
130570417  bmp3; bone morphogenetic protein 3 [KO:K05496]
130570459  prlra; LOW QUALITY PROTEIN: prolactin receptor a [KO:K05081]
130570653  lifrb; LIF receptor subunit alpha b [KO:K05058]
130570769  il7r; interleukin-7 receptor subunit alpha [KO:K05072]
130570962  tnfrsf1b; tumor necrosis factor receptor superfamily member 1B [KO:K05141]
130571023  il17rc; uncharacterized protein il17rc [KO:K05166]
130571226  bmp7a; bone morphogenetic protein 7a [KO:K16621]
130571262  il10; interleukin-10 [KO:K05443]
130571311  tnfrsf9b; tumor necrosis factor receptor superfamily member 9b isoform X1 [KO:K05146]
130571327  [KO:K22629]
130571461  il19l; interleukin 19 like [KO:K22667]
130571500  il12rb1; interleukin-31 receptor subunit alpha isoform X1 [KO:K05063]
130571573  tnfsf13; tumor necrosis factor ligand superfamily member 13 isoform X1 [KO:K05475]
130571710  ccl25b; C-C motif chemokine 25b [KO:K13072]
130571733  csf1a; macrophage colony-stimulating factor 1a [KO:K05453]
130571735  [KO:K22687]
130571871  bmp7b; bone morphogenetic protein 7b [KO:K16621]
130571904  acvr1ba; activin A receptor type 1Ba [KO:K13567] [EC:2.7.11.30]
130571915  [KO:K10032]
Reference
PMID:24892271
  Authors
Turner MD, Nedjai B, Hurst T, Pennington DJ
  Title
Cytokines and chemokines: At the crossroads of cell signalling and inflammatory disease.
  Journal
Biochim Biophys Acta 1843:2563-2582 (2014)
DOI:10.1016/j.bbamcr.2014.05.014
Reference
PMID:21106488
  Authors
Brocker C, Thompson D, Matsumoto A, Nebert DW, Vasiliou V
  Title
Evolutionary divergence and functions of the human interleukin (IL) gene family.
  Journal
Hum Genomics 5:30-55 (2010)
DOI:10.1186/1479-7364-5-1-30
Reference
PMID:27577879
  Authors
Akdis M, Aab A, Altunbulakli C, Azkur K, Costa RA, Crameri R, Duan S, Eiwegger T, Eljaszewicz A, Ferstl R, Frei R, Garbani M, Globinska A, Hess L, Huitema C, Kubo T, Komlosi Z, Konieczna P, Kovacs N, Kucuksezer UC, Meyer N, Morita H, Olzhausen J, O'Mahony L, Pezer M, Prati M, Rebane A, Rhyner C, Rinaldi A, Sokolowska M, Stanic B, Sugita K, Treis A, van de Veen W, Wanke K, Wawrzyniak M, Wawrzyniak P, Wirz OF, Zakzuk JS, Akdis CA
  Title
Interleukins (from IL-1 to IL-38), interferons, transforming growth factor beta, and TNF-alpha: Receptors, functions, and roles in diseases.
  Journal
J Allergy Clin Immunol 138:984-1010 (2016)
DOI:10.1016/j.jaci.2016.06.033
Reference
PMID:15500860
  Authors
Boulanger MJ, Garcia KC
  Title
Shared cytokine signaling receptors: structural insights from the gp130 system.
  Journal
Adv Protein Chem 68:107-46 (2004)
DOI:10.1016/S0065-3233(04)68004-1
Reference
PMID:16034365
  Authors
Allan SM, Tyrrell PJ, Rothwell NJ
  Title
Interleukin-1 and neuronal injury.
  Journal
Nat Rev Immunol 5:629-40 (2005)
DOI:10.1038/nri1664
Reference
PMID:23847622
  Authors
Lopetuso LR, Chowdhry S, Pizarro TT
  Title
Opposing Functions of Classic and Novel IL-1 Family Members in Gut Health and Disease.
  Journal
Front Immunol 4:181 (2013)
DOI:10.3389/fimmu.2013.00181
Reference
PMID:21349428
  Authors
Iwakura Y, Ishigame H, Saijo S, Nakae S
  Title
Functional specialization of interleukin-17 family members.
  Journal
Immunity 34:149-62 (2011)
DOI:10.1016/j.immuni.2011.02.012
Reference
PMID:17530315
  Authors
Fischer P, Hilfiker-Kleiner D
  Title
Survival pathways in hypertrophy and heart failure: the gp130-STAT3 axis.
  Journal
Basic Res Cardiol 102:279-97 (2007)
DOI:10.1007/s00395-007-0658-z
Reference
PMID:24381786
  Authors
Richards CD
  Title
The enigmatic cytokine oncostatin m and roles in disease.
  Journal
ISRN Inflamm 2013:512103 (2013)
DOI:10.1155/2013/512103
Reference
PMID:18926762
  Authors
Zhang Q, Putheti P, Zhou Q, Liu Q, Gao W
  Title
Structures and biological functions of IL-31 and IL-31 receptors.
  Journal
Cytokine Growth Factor Rev 19:347-56 (2008)
DOI:10.1016/j.cytogfr.2008.08.003
Reference
PMID:21155715
  Authors
Meenhuis A, Verwijmeren C, Roovers O, Touw IP
  Title
The deubiquitinating enzyme DUB2A enhances CSF3 signalling by attenuating lysosomal routing of the CSF3 receptor.
  Journal
Biochem J 434:343-51 (2011)
DOI:10.1042/BJ20101628
Reference
PMID:22410872
  Authors
de Weerd NA, Nguyen T
  Title
The interferons and their receptors--distribution and regulation.
  Journal
Immunol Cell Biol 90:483-91 (2012)
DOI:10.1038/icb.2012.9
Reference
PMID:12949498
  Authors
Aggarwal BB
  Title
Signalling pathways of the TNF superfamily: a double-edged sword.
  Journal
Nat Rev Immunol 3:745-56 (2003)
DOI:10.1038/nri1184
Reference
PMID:12189384
  Authors
Ashkenazi A
  Title
Targeting death and decoy receptors of the tumour-necrosis factor superfamily.
  Journal
Nat Rev Cancer 2:420-30 (2002)
DOI:10.1038/nrc821
Reference
PMID:26115564
  Authors
Seeger P, Musso T, Sozzani S
  Title
The TGF-beta superfamily in dendritic cell biology.
  Journal
Cytokine Growth Factor Rev 26:647-57 (2015)
DOI:10.1016/j.cytogfr.2015.06.002
Reference
PMID:23612460
  Authors
Wakefield LM, Hill CS
  Title
Beyond TGFbeta: roles of other TGFbeta superfamily members in cancer.
  Journal
Nat Rev Cancer 13:328-41 (2013)
DOI:10.1038/nrc3500
Reference
PMID:22710174
  Authors
Mueller TD, Nickel J
  Title
Promiscuity and specificity in BMP receptor activation.
  Journal
FEBS Lett 586:1846-59 (2012)
DOI:10.1016/j.febslet.2012.02.043
KO pathway
ko04060   

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