KEGG   PATHWAY: zvi04020
Entry
zvi04020                    Pathway                                
Name
Calcium signaling pathway - Zootoca vivipara (common lizard)
Description
Ca2+ that enters the cell from the outside is a principal source of signal Ca2+. Entry of Ca2+ is driven by the presence of a large electrochemical gradient across the plasma membrane. Cells use this external source of signal Ca2+ by activating various entry channels with widely different properties. The voltage-operated channels (VOCs) are found in excitable cells and generate the rapid Ca2+ fluxes that control fast cellular processes. There are many other Ca2+-entry channels, such as the receptor-operated channels (ROCs), for example the NMDA (N-methyl-D-aspartate) receptors (NMDARs) that respond to glutamate. There also are second-messenger-operated channels (SMOCs) and store-operated channels (SOCs).
The other principal source of Ca2+ for signalling is the internal stores that are located primarily in the endoplasmic/sarcoplasmic reticulum (ER/SR), in which inositol-1,4,5-trisphosphate receptors (IP3Rs) or ryanodine receptors (RYRs) regulate the release of Ca2+. The principal activator of these channels is Ca2+ itself and this process of Ca2+-induced Ca2+ release is central to the mechanism of Ca2+ signalling. Various second messengers or modulators also control the release of Ca2+. IP3, which is generated by pathways using different isoforms of phospholipase C (PLCbeta, delta, epsilon, gamma and zeta), regulates the IP3Rs. Cyclic ADP-ribose (cADPR) releases Ca2+ via RYRs. Nicotinic acid adenine dinucleotide phosphate (NAADP) may activate a distinct Ca2+ release mechanism on separate acidic Ca2+ stores. Ca2+ release via the NAADP-sensitive mechanism may also feedback onto either RYRs or IP3Rs. cADPR and NAADP are generated by CD38. This enzyme might be sensitive to the cellular metabolism, as ATP and NADH inhibit it.
The influx of Ca2+ from the environment or release from internal stores causes a very rapid and dramatic increase in cytoplasmic calcium concentration, which has been widely exploited for signal transduction. Some proteins, such as troponin C (TnC) involved in muscle contraction, directly bind to and sense Ca2+. However, in other cases Ca2+ is sensed through intermediate calcium sensors such as calmodulin (CALM).
Class
Environmental Information Processing; Signal transduction
Pathway map
zvi04020  Calcium signaling pathway
zvi04020

Other DBs
GO: 0019722
Organism
Zootoca vivipara (common lizard) [GN:zvi]
Gene
118075200  ATP2B3; plasma membrane calcium-transporting ATPase 3 isoform X1 [KO:K05850] [EC:7.2.2.10]
118075379  CASQ2; calsequestrin-2 [KO:K23445]
118075566  ATP2A2; sarcoplasmic/endoplasmic reticulum calcium ATPase 2 isoform X1 [KO:K05853] [EC:7.2.2.10]
118075638  ORAI1; calcium release-activated calcium channel protein 1 isoform X1 [KO:K16056]
118075670  PLCB3; 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-3 isoform X1 [KO:K05858] [EC:3.1.4.11]
118075713  P2RX7; P2X purinoceptor 7 isoform X1 [KO:K05220]
118075714  P2RX4; P2X purinoceptor 4 [KO:K05218]
118075739  [KO:K00911] [EC:2.7.1.127]
118075798  TPCN1; two pore calcium channel protein 1 isoform X1 [KO:K16896]
118075881  CASQ1; calsequestrin-1 [KO:K23468]
118075928  ADORA2A; adenosine receptor A2a [KO:K04266]
118075945  [KO:K04809]
118075983  NOS1; nitric oxide synthase, brain isoform X1 [KO:K13240] [EC:1.14.13.39]
118076046  CHRM1; muscarinic acetylcholine receptor M1 [KO:K04129]
118076180  P2RX6; P2X purinoceptor 6 [KO:K05221]
118076186  P2RX2; P2X purinoceptor 2 [KO:K05216]
118076311  VEGFB; vascular endothelial growth factor B [KO:K16858]
118076375  [KO:K05849]
118076518  [KO:K02183]
118076712  NTRK2; BDNF/NT-3 growth factors receptor isoform X1 [KO:K04360] [EC:2.7.10.1]
118076877  [KO:K03914]
118076879  [KO:K03914]
118076922  [KO:K03914]
118076993  [KO:K03914]
118077001  CAMK4; calcium/calmodulin-dependent protein kinase type IV [KO:K05869] [EC:2.7.11.17]
118077035  [KO:K04636]
118077036  [KO:K04634]
118077090  FGF10; fibroblast growth factor 10 [KO:K04358]
118077295  GDNF; glial cell line-derived neurotrophic factor isoform X1 [KO:K05452]
118077433  [KO:K02183]
118077549  [KO:K04163]
118077623  ADCY2; adenylate cyclase type 2 isoform X1 [KO:K08042] [EC:4.6.1.1]
118077636  PDE1B; calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1B isoform X1 [KO:K13755] [EC:3.1.4.17]
118077665  EGFR; epidermal growth factor receptor isoform X1 [KO:K04361] [EC:2.7.10.1]
118077681  ADCY1; adenylate cyclase type 1 [KO:K08041] [EC:4.6.1.1]
118077690  [KO:K06268]
118077759  [KO:K05213]
118078145  [KO:K05852]
118078175  CALM1; calmodulin-1 isoform X1 [KO:K02183]
118078263  [KO:K05094] [EC:2.7.10.1]
118078279  CYSLTR1; cysteinyl leukotriene receptor 1 [KO:K04322]
118078718  ADCY4; adenylate cyclase type 4 isoform X1 [KO:K08044] [EC:4.6.1.1]
118078720  NFATC4; nuclear factor of activated T-cells, cytoplasmic 4 [KO:K17334]
118078725  LTB4R; leukotriene B4 receptor 1 isoform X1 [KO:K04297]
118078745  [KO:K00476] [EC:1.14.11.16]
118078746  [KO:K00476] [EC:1.14.11.16]
118079070  ADRA1D; alpha-1D adrenergic receptor [KO:K04137]
118079120  CHRNA7; neuronal acetylcholine receptor subunit alpha-7 [KO:K04809]
118079615  ERBB3; receptor tyrosine-protein kinase erbB-3 [KO:K05084] [EC:2.7.10.1]
118079639  PRKCA; protein kinase C alpha type isoform X1 [KO:K02677] [EC:2.7.11.13]
118079785  CACNA1G; voltage-dependent T-type calcium channel subunit alpha-1G isoform X1 [KO:K04854]
118079802  GRIN2C; glutamate receptor ionotropic, NMDA 2C [KO:K05211]
118079862  SPHK1; sphingosine kinase 1 [KO:K04718] [EC:2.7.1.91]
118079974  PTGER1; prostaglandin E2 receptor EP1 subtype [KO:K04258]
118079980  PRKACA; cAMP-dependent protein kinase catalytic subunit alpha isoform X1 [KO:K04345] [EC:2.7.11.11]
118079990  CACNA1A; voltage-dependent P/Q-type calcium channel subunit alpha-1A isoform X1 [KO:K04344]
118080072  CAMK1; calcium/calmodulin-dependent protein kinase type 1 [KO:K08794] [EC:2.7.11.17]
118080272  HTR4; 5-hydroxytryptamine receptor 4 isoform X1 [KO:K04160]
118080289  ADRB2; beta-2 adrenergic receptor [KO:K04142]
118080327  FGF1; fibroblast growth factor 1 [KO:K18496]
118080354  VDAC1; voltage-dependent anion-selective channel protein 1 isoform X1 [KO:K05862]
118080415  FLT4; vascular endothelial growth factor receptor 3 [KO:K05097] [EC:2.7.10.1]
118080419  PDGFRB; platelet-derived growth factor receptor beta [KO:K05089] [EC:2.7.10.1]
118080422  CAMK2A; calcium/calmodulin-dependent protein kinase type II subunit alpha isoform X1 [KO:K04515] [EC:2.7.11.17]
118080484  HRH2; histamine H2 receptor [KO:K04150]
118080501  FGFR4; fibroblast growth factor receptor 4 isoform X1 [KO:K05095] [EC:2.7.10.1]
118080562  MST1R; macrophage-stimulating protein receptor isoform X1 [KO:K05100] [EC:2.7.10.1]
118080577  MST1; hepatocyte growth factor-like protein isoform X1 [KO:K23441]
118080624  TNNC1; troponin C, slow skeletal and cardiac muscles [KO:K05865]
118080658  ATP2B2; plasma membrane calcium-transporting ATPase 2 isoform X1 [KO:K05850] [EC:7.2.2.10]
118080661  HRH1; histamine H1 receptor [KO:K04149]
118080704  CACNA1D; voltage-dependent L-type calcium channel subunit alpha-1D [KO:K04851]
118080796  OXTR; oxytocin receptor [KO:K04229]
118080803  ITPR1; inositol 1,4,5-trisphosphate receptor type 1 isoform X1 [KO:K04958]
118080804  [KO:K03916]
118081520  DRD1; D(1A) dopamine receptor [KO:K04144]
118081774  VEGFA; vascular endothelial growth factor A isoform X1 [KO:K05448]
118081851  CHRM3; muscarinic acetylcholine receptor M3 [KO:K04131]
118081853  RYR2; ryanodine receptor 2 [KO:K04962]
118082162  PLN; cardiac phospholamban [KO:K05852]
118082184  TRDN; triadin isoform X1 [KO:K23449]
118082496  PLCB4; 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-4 isoform X1 [KO:K05858] [EC:3.1.4.11]
118082497  PLCB1; 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-1 isoform X1 [KO:K05858] [EC:3.1.4.11]
118082516  FGF18; LOW QUALITY PROTEIN: fibroblast growth factor 18 [KO:K04358]
118082582  PPP3R1; calcineurin subunit B type 1 isoform X1 [KO:K06268]
118082597  [KO:K13755] [EC:3.1.4.17]
118082832  GRM1; metabotropic glutamate receptor 1 isoform X1 [KO:K04603]
118082895  CHRM5; muscarinic acetylcholine receptor M5 [KO:K04133]
118082931  RYR3; ryanodine receptor 3 [KO:K04963]
118082945  PTK2B; protein-tyrosine kinase 2-beta [KO:K05871] [EC:2.7.10.2]
118082958  ADCY3; adenylate cyclase type 3 [KO:K08043] [EC:4.6.1.1]
118083014  [KO:K04161]
118083025  SLC8A1; sodium/calcium exchanger 1 isoform X1 [KO:K05849]
118083058  PLCB2; 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-2 isoform X1 [KO:K05858] [EC:3.1.4.11]
118083088  CALM2; calmodulin-2 [KO:K02183]
118083231  ITPKB; inositol-trisphosphate 3-kinase B [KO:K00911] [EC:2.7.1.127]
118083339  PDGFC; platelet-derived growth factor C [KO:K05450]
118083395  ITPKA; inositol-trisphosphate 3-kinase A [KO:K00911] [EC:2.7.1.127]
118083408  VEGFC; vascular endothelial growth factor C isoform X1 [KO:K05449]
118083506  TACR3; neuromedin-K receptor [KO:K04224]
118083517  FGF2; fibroblast growth factor 2 [KO:K18497]
118083531  DRD5; LOW QUALITY PROTEIN: D(1B) dopamine receptor [KO:K05840]
118083576  PDGFRA; platelet-derived growth factor receptor alpha isoform X1 [KO:K04363] [EC:2.7.10.1]
118083589  STIM2; stromal interaction molecule 2 isoform X1 [KO:K18196]
118083590  PPP3CA; serine/threonine-protein phosphatase 2B catalytic subunit alpha isoform isoform X1 [KO:K04348] [EC:3.1.3.16]
118083694  EDNRA; endothelin-1 receptor [KO:K04197]
118083713  EGF; pro-epidermal growth factor [KO:K04357]
118083716  SLC25A31; ADP/ATP translocase 4 [KO:K05863]
118083754  KDR; vascular endothelial growth factor receptor 2 [KO:K05098] [EC:2.7.10.1]
118083808  [KO:K07190]
118083834  CACNA1B; voltage-dependent N-type calcium channel subunit alpha-1B isoform X1 [KO:K04849]
118083921  [KO:K04157]
118083926  SLC25A4; ADP/ATP translocase 1 [KO:K05863]
118083949  CAMK2D; calcium/calmodulin-dependent protein kinase type II subunit delta isoform X1 [KO:K04515] [EC:2.7.11.17]
118084020  CD38; ADP-ribosyl cyclase/cyclic ADP-ribose hydrolase 1 isoform X1 [KO:K01242] [EC:3.2.2.6 2.4.99.20]
118084069  FGF20; fibroblast growth factor 20 [KO:K04358]
118084088  SLC8A3; sodium/calcium exchanger 3 isoform X1 [KO:K05849]
118084130  FGF5; fibroblast growth factor 5 [KO:K04358]
118084151  [KO:K05096] [EC:2.7.10.1]
118084180  FGF16; fibroblast growth factor 16 isoform X1 [KO:K04358]
118084360  SLC25A5; ADP/ATP translocase 2 [KO:K05863]
118084367  [KO:K04198]
118084478  CCKAR; cholecystokinin receptor type A isoform X1 [KO:K04194]
118084634  FLT1; vascular endothelial growth factor receptor 1 isoform X1 [KO:K05096] [EC:2.7.10.1]
118084911  SLC25A6; ADP/ATP translocase 3 [KO:K05863]
118085048  CCKBR; gastrin/cholecystokinin type B receptor [KO:K04195]
118085080  FGF3; fibroblast growth factor 3 [KO:K04358]
118085173  SLN; sarcolipin [KO:K22642]
118085232  PDGFD; platelet-derived growth factor D [KO:K05450]
118085281  VEGFD; vascular endothelial growth factor D [KO:K05449]
118085284  GRPR; gastrin-releasing peptide receptor [KO:K04169]
118085463  EDNRB; endothelin receptor type B [KO:K04198]
118085495  GRM5; metabotropic glutamate receptor 5 [KO:K04604]
118085578  STIM1; stromal interaction molecule 1 isoform X1 [KO:K16059]
118085675  PHKA2; phosphorylase b kinase regulatory subunit alpha, liver isoform isoform X1 [KO:K07190]
118085775  FGF9; fibroblast growth factor 9 [KO:K04358]
118085868  PTAFR; platelet-activating factor receptor [KO:K04279]
118085950  FGF19; fibroblast growth factor 19 [KO:K22603]
118085963  TPCN2; LOW QUALITY PROTEIN: two pore calcium channel protein 2 [KO:K14077]
118085968  VDAC3; voltage-dependent anion-selective channel protein 3 [KO:K15041]
118085993  ADCY7; adenylate cyclase type 7 isoform X1 [KO:K08047] [EC:4.6.1.1]
118086010  TBXA2R; thromboxane A2 receptor [KO:K04264]
118086017  [KO:K05869] [EC:2.7.11.17]
118086090  PHKB; phosphorylase b kinase regulatory subunit beta isoform X1 [KO:K07190]
118086099  GRIN3B; glutamate receptor ionotropic, NMDA 3B [KO:K05214]
118086354  [KO:K04157]
118086362  NFATC3; nuclear factor of activated T-cells, cytoplasmic 3 [KO:K17333]
118086473  [KO:K04635]
118086525  GRIN1; glutamate receptor ionotropic, NMDA 1 [KO:K05208]
118086713  MYLK3; myosin light chain kinase 3 isoform X1 [KO:K00907] [EC:2.7.11.18]
118086789  [KO:K04282]
118086868  TACR1; substance-P receptor [KO:K04222]
118086895  RYR1; LOW QUALITY PROTEIN: ryanodine receptor 1 [KO:K04961]
118087100  CALM3; calmodulin-3 [KO:K02183]
118087202  CALML6; calmodulin-like protein 6 [KO:K02183]
118087205  SLC8A2; sodium/calcium exchanger 2 [KO:K05849]
118087285  [KO:K04637]
118087372  TGFA; protransforming growth factor alpha isoform X1 [KO:K08774]
118087544  ITPKC; inositol-trisphosphate 3-kinase C isoform X1 [KO:K00911] [EC:2.7.1.127]
118087771  FGF22; fibroblast growth factor 22 [KO:K04358]
118087873  PLCG2; 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-2 isoform X1 [KO:K05859] [EC:3.1.4.11]
118087991  HTR6; 5-hydroxytryptamine receptor 6 [KO:K04162]
118088146  ATP2B4; plasma membrane calcium-transporting ATPase 4 isoform X1 [KO:K05850] [EC:7.2.2.10]
118088152  FGF4; fibroblast growth factor 4 [KO:K04358]
118088232  TFEB; transcription factor EB [KO:K15590]
118088233  PRKACB; cAMP-dependent protein kinase catalytic subunit beta isoform X1 [KO:K04345] [EC:2.7.11.11]
118088305  NFATC2; nuclear factor of activated T-cells, cytoplasmic 2 isoform X1 [KO:K17332]
118088554  CACNA1S; voltage-dependent L-type calcium channel subunit alpha-1S isoform X1 [KO:K04857]
118088582  PTGER3; prostaglandin E2 receptor EP3 subtype [KO:K04260]
118088703  CAMK1G; calcium/calmodulin-dependent protein kinase type 1G [KO:K08794] [EC:2.7.11.17]
118088787  CACNA1E; voltage-dependent R-type calcium channel subunit alpha-1E [KO:K04852]
118088799  MYLK2; myosin light chain kinase 2, skeletal/cardiac muscle [KO:K00907] [EC:2.7.11.18]
118088804  TNNC2; troponin C, skeletal muscle isoform X1 [KO:K12042]
118088856  PLCG1; 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1 isoform X1 [KO:K01116] [EC:3.1.4.11]
118088921  MCOLN2; mucolipin-2 isoform X1 [KO:K04993]
118089017  GNAS; guanine nucleotide-binding protein G(s) subunit alpha isoform X1 [KO:K04632]
118089025  MCOLN3; mucolipin-3 isoform X1 [KO:K04994]
118089037  NGF; beta-nerve growth factor [KO:K02582]
118089198  AVPR1B; vasopressin V1b receptor [KO:K04227]
118089337  [KO:K04282]
118089408  ITPR3; inositol 1,4,5-trisphosphate receptor type 3 isoform X1 [KO:K04960]
118089431  NTSR1; neurotensin receptor type 1 [KO:K04211]
118089467  PTGFR; prostaglandin F2-alpha receptor [KO:K04262]
118089792  GNAL; guanine nucleotide-binding protein G(olf) subunit alpha isoform X1 [KO:K04633]
118089856  [KO:K01116] [EC:3.1.4.11]
118089891  P2RX3; P2X purinoceptor 3 [KO:K05217]
118089989  ADCY8; LOW QUALITY PROTEIN: adenylate cyclase type 8 [KO:K08048] [EC:4.6.1.1]
118090072  [KO:K00907] [EC:2.7.11.18]
118090213  TRHR; thyrotropin-releasing hormone receptor [KO:K04282]
118090397  ASPH; aspartyl/asparaginyl beta-hydroxylase [KO:K00476] [EC:1.14.11.16]
118090569  NFATC1; nuclear factor of activated T-cells, cytoplasmic 1 isoform X1 [KO:K04446]
118090657  ATP2B1; plasma membrane calcium-transporting ATPase 1 isoform X1 [KO:K05850] [EC:7.2.2.10]
118090716  MET; hepatocyte growth factor receptor [KO:K05099] [EC:2.7.10.1]
118090932  CACNA1C; voltage-dependent L-type calcium channel subunit alpha-1C isoform X1 [KO:K04850]
118090974  PDGFB; platelet-derived growth factor subunit B isoform X1 [KO:K17386]
118091007  ITPR2; inositol 1,4,5-trisphosphate receptor type 2 isoform X1 [KO:K04959]
118091011  PLCD4; 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase delta-4 isoform X1 [KO:K05857] [EC:3.1.4.11]
118091045  GRIN2B; glutamate receptor ionotropic, NMDA 2B [KO:K05210]
118091060  CAMK1D; calcium/calmodulin-dependent protein kinase type 1D [KO:K08794] [EC:2.7.11.17]
118091097  CHRM2; muscarinic acetylcholine receptor M2 [KO:K04130]
118091119  AVPR1A; vasopressin V1a receptor [KO:K04226]
118091191  [KO:K05861] [EC:3.1.4.11]
118091194  [KO:K05861] [EC:3.1.4.11]
118091334  HGF; hepatocyte growth factor isoform X1 [KO:K05460]
118091357  CACNA1I; voltage-dependent T-type calcium channel subunit alpha-1I [KO:K04856]
118091433  [KO:K02183]
118091732  PDE1C; calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1C isoform X1 [KO:K13755] [EC:3.1.4.17]
118091777  MYLK; myosin light chain kinase, smooth muscle isoform X1 [KO:K00907] [EC:2.7.11.18]
118091831  PLCD1; 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase delta-1 isoform X1 [KO:K05857] [EC:3.1.4.11]
118092264  NOS3; nitric oxide synthase, endothelial isoform X1 [KO:K13242] [EC:1.14.13.39]
118092332  HTR5A; 5-hydroxytryptamine receptor 5A [KO:K04161]
118092483  PDGFA; platelet-derived growth factor subunit A isoform X1 [KO:K04359]
118092519  CXCR4; C-X-C chemokine receptor type 4 [KO:K04189]
118092532  CALML4; calmodulin-like protein 4 [KO:K02183]
118092541  CACNA1H; voltage-dependent T-type calcium channel subunit alpha-1H [KO:K04855]
118092573  PRKCB; protein kinase C beta type isoform X1 [KO:K19662] [EC:2.7.11.13]
118092767  GRIN2A; glutamate receptor ionotropic, NMDA 2A [KO:K05209]
118092905  ADCY9; adenylate cyclase type 9 [KO:K08049] [EC:4.6.1.1]
118092994  FGF7; fibroblast growth factor 7 [KO:K04358]
118093072  NTRK3; NT-3 growth factor receptor isoform X1 [KO:K05101] [EC:2.7.10.1]
118093408  ADRB1; beta-1 adrenergic receptor [KO:K04141]
118093608  AGTR1; type-1 angiotensin II receptor [KO:K04166]
118093802  FGF8; fibroblast growth factor 8 [KO:K04358]
118093850  PDE1A; calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A isoform X1 [KO:K13755] [EC:3.1.4.17]
118094013  HTR2B; 5-hydroxytryptamine receptor 2B isoform X1 [KO:K04157]
118094199  ERBB2; receptor tyrosine-protein kinase erbB-2 [KO:K05083] [EC:2.7.10.1]
118094273  ATP2A1; sarcoplasmic/endoplasmic reticulum calcium ATPase 1 isoform X1 [KO:K05853] [EC:7.2.2.10]
118094558  [KO:K04150]
118094565  SPHK2; sphingosine kinase 2 [KO:K04718] [EC:2.7.1.91]
118094598  NTRK1; high affinity nerve growth factor receptor isoform X1 [KO:K03176] [EC:2.7.10.1]
118094673  PHKG2; phosphorylase b kinase gamma catalytic chain, liver/testis isoform [KO:K00871] [EC:2.7.11.19]
118094978  PRKCG; protein kinase C gamma type [KO:K19663] [EC:2.7.11.13]
118095173  FGF21; fibroblast growth factor 21 [KO:K22429]
118095175  HRC; sarcoplasmic reticulum histidine-rich calcium-binding protein [KO:K23450]
118095395  GRIN2D; glutamate receptor ionotropic, NMDA 2D [KO:K05212]
118095662  [KO:K05850] [EC:7.2.2.10]
118095717  [KO:K10784]
118095911  PLCD3; 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase delta-3 [KO:K05857] [EC:3.1.4.11]
118096107  TACR2; substance-K receptor [KO:K04223]
118096112  MCU; calcium uniporter protein, mitochondrial isoform X1 [KO:K20858]
118096206  PPP3CB; serine/threonine-protein phosphatase 2B catalytic subunit beta isoform isoform X1 [KO:K04348] [EC:3.1.3.16]
118096290  PLCE1; 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase epsilon-1 isoform X1 [KO:K05860] [EC:3.1.4.11]
118096309  VDAC2; voltage-dependent anion-selective channel protein 2 isoform X1 [KO:K15040]
118096313  FGF6; fibroblast growth factor 6 [KO:K04358]
118096328  FGF23; LOW QUALITY PROTEIN: fibroblast growth factor 23 [KO:K22428]
118096357  FGFR2; fibroblast growth factor receptor 2 isoform X1 [KO:K05093] [EC:2.7.10.1]
118096361  RET; proto-oncogene tyrosine-protein kinase receptor Ret isoform X1 [KO:K05126] [EC:2.7.10.1]
118096382  PPIF; peptidyl-prolyl cis-trans isomerase F, mitochondrial [KO:K09565] [EC:5.2.1.8]
118096405  CAMK2G; calcium/calmodulin-dependent protein kinase type II subunit gamma isoform X1 [KO:K04515] [EC:2.7.11.17]
118096469  [KO:K05840]
118096480  FGFR3; fibroblast growth factor receptor 3 isoform X1 [KO:K05094] [EC:2.7.10.1]
118096559  [KO:K05850] [EC:7.2.2.10]
118096567  HTR7; 5-hydroxytryptamine receptor 7 [KO:K04163]
118096713  ERBB4; receptor tyrosine-protein kinase erbB-4 isoform X1 [KO:K05085] [EC:2.7.10.1]
118096835  CAMK2B; calcium/calmodulin-dependent protein kinase type II subunit beta isoform X1 [KO:K04515] [EC:2.7.11.17]
118096852  [KO:K05853] [EC:7.2.2.10]
118096907  ADRA1A; alpha-1A adrenergic receptor isoform X1 [KO:K04135]
118096950  P2RX5; P2X purinoceptor 5 isoform X1 [KO:K05219]
118096970  [KO:K05840]
118097034  PHKG1; phosphorylase b kinase gamma catalytic chain, skeletal muscle/heart isoform [KO:K00871] [EC:2.7.11.19]
118097100  PPP3CC; serine/threonine-protein phosphatase 2B catalytic subunit gamma isoform isoform X1 [KO:K04348] [EC:3.1.3.16]
118097118  ADORA2B; adenosine receptor A2b [KO:K04267]
118097149  ADRB3; beta-3 adrenergic receptor isoform X1 [KO:K04143]
118097182  FGFR1; fibroblast growth factor receptor 1 isoform X1 [KO:K04362] [EC:2.7.10.1]
118097243  NOS2; nitric oxide synthase, inducible [KO:K13241] [EC:1.14.13.39]
118097363  ORAI2; protein orai-2 [KO:K16057]
118097364  P2RX1; P2X purinoceptor 1 isoform X1 [KO:K05215]
118097569  CACNA1F; voltage-dependent L-type calcium channel subunit alpha-1F [KO:K04853]
118097790  GRIN3A; glutamate receptor ionotropic, NMDA 3A [KO:K05213]
118097814  [KO:K04809]
118097908  MCOLN1; mucolipin-1 isoform X1 [KO:K04992]
Compound
C00002  ATP
C00004  NADH
C00076  Calcium cation
C00165  Diacylglycerol
C00575  3',5'-Cyclic AMP
C01245  D-myo-Inositol 1,4,5-trisphosphate
C01330  Sodium cation
C06124  Sphingosine 1-phosphate
C11556  1-Phosphatidyl-1D-myo-inositol 3,5-bisphosphate
C13050  Cyclic ADP-ribose
C13051  Nicotinic acid adenine dinucleotide phosphate
Reference
PMID:12838335
  Authors
Berridge MJ, Bootman MD, Roderick HL.
  Title
Calcium signalling: dynamics, homeostasis and remodelling.
  Journal
Nat Rev Mol Cell Biol 4:517-29 (2003)
DOI:10.1038/nrm1155
Reference
PMID:11413485
  Authors
Berridge MJ, Lipp P, Bootman MD.
  Title
The versatility and universality of calcium signalling.
  Journal
Nat Rev Mol Cell Biol 1:11-21 (2000)
DOI:10.1038/35036035
Reference
PMID:15111104
  Authors
Wang MC, Dolphin A, Kitmitto A.
  Title
L-type voltage-gated calcium channels: understanding function through structure.
  Journal
FEBS Lett 564:245-50 (2004)
DOI:10.1016/S0014-5793(04)00253-4
Reference
PMID:11299192
  Authors
Ferrier GR, Howlett SE.
  Title
Cardiac excitation-contraction coupling: role of membrane potential in regulation of contraction.
  Journal
Am J Physiol Heart Circ Physiol 280:H1928-44 (2001)
DOI:10.1152/ajpheart.2001.280.5.H1928
Reference
PMID:11698232
  Authors
Keef KD, Hume JR, Zhong J.
  Title
Regulation of cardiac and smooth muscle Ca(2+) channels (Ca(V)1.2a,b) by protein kinases.
  Journal
Am J Physiol Cell Physiol 281:C1743-56 (2001)
DOI:10.1152/ajpcell.2001.281.6.C1743
Reference
PMID:8125957
  Authors
Hell JW, Appleyard SM, Yokoyama CT, Warner C, Catterall WA.
  Title
Differential phosphorylation of two size forms of the N-type calcium channel alpha 1 subunit which have different COOH termini.
  Journal
J Biol Chem 269:7390-6 (1994)
Reference
PMID:15000521
  Authors
Yunker AM.
  Title
Modulation and pharmacology of low voltage-activated ("T-Type") calcium channels.
  Journal
J Bioenerg Biomembr 35:577-98 (2003)
DOI:10.1023/B:JOBB.0000008025.65675.37
Reference
PMID:9149541
  Authors
Yakel JL.
  Title
Calcineurin regulation of synaptic function: from ion channels to transmitter release and gene transcription.
  Journal
Trends Pharmacol Sci 18:124-34 (1997)
DOI:10.1016/S0165-6147(97)01046-8
Reference
PMID:10997573
  Authors
Fukunaga K, Miyamoto E.
  Title
A working model of CaM kinase II activity in hippocampal long-term potentiation and memory.
  Journal
Neurosci Res 38:3-17 (2000)
DOI:10.1016/S0168-0102(00)00139-5
Reference
PMID:9235901
  Authors
Della Rocca GJ, van Biesen T, Daaka Y, Luttrell DK, Luttrell LM, Lefkowitz RJ.
  Title
Ras-dependent mitogen-activated protein kinase activation by G protein-coupled receptors. Convergence of Gi- and Gq-mediated pathways on calcium/calmodulin, Pyk2, and Src kinase.
  Journal
J Biol Chem 272:19125-32 (1997)
DOI:10.1074/jbc.272.31.19125
Reference
PMID:7861177
  Authors
Furuichi T, Mikoshiba K.
  Title
Inositol 1, 4, 5-trisphosphate receptor-mediated Ca2+ signaling in the brain.
  Journal
J Neurochem 64:953-60 (1995)
DOI:10.1046/j.1471-4159.1995.64030953.x
Reference
PMID:14572802
  Authors
Bruce JI, Straub SV, Yule DI.
  Title
Crosstalk between cAMP and Ca2+ signaling in non-excitable cells.
  Journal
Cell Calcium 34:431-44 (2003)
DOI:10.1016/S0143-4160(03)00150-7
Reference
PMID:10331643
  Authors
Lee HC, Munshi C, Graeff R.
  Title
Structures and activities of cyclic ADP-ribose, NAADP and their metabolic enzymes.
  Journal
Mol Cell Biochem 193:89-98 (1999)
DOI:10.1007/978-1-4419-8740-2_13
Reference
PMID:11080247
  Authors
Crompton M.
  Title
Mitochondrial intermembrane junctional complexes and their role in cell death.
  Journal
J Physiol 529 Pt 1:11-21 (2000)
DOI:10.1111/j.1469-7793.2000.00011.x
Reference
PMID:10508738
  Authors
Grewal SS, York RD, Stork PJ.
  Title
Extracellular-signal-regulated kinase signalling in neurons.
  Journal
Curr Opin Neurobiol 9:544-53 (1999)
DOI:10.1016/S0959-4388(99)00010-0
Reference
PMID:12972622
  Authors
Trushin SA, Pennington KN, Carmona EM, Asin S, Savoy DN, Billadeau DD, Paya CV.
  Title
Protein kinase Calpha (PKCalpha) acts upstream of PKCtheta to activate IkappaB kinase and NF-kappaB in T lymphocytes.
  Journal
Mol Cell Biol 23:7068-81 (2003)
DOI:10.1128/MCB.23.19.7068-7081.2003
Reference
PMID:14517314
  Authors
Hutchins JR, Dikovskaya D, Clarke PR.
  Title
Regulation of Cdc2/cyclin B activation in Xenopus egg extracts via inhibitory phosphorylation of Cdc25C phosphatase by Ca(2+)/calmodulin-dependent protein [corrected] kinase II.
  Journal
Mol Biol Cell 14:4003-14 (2003)
DOI:10.1091/mbc.E03-02-0061
Reference
PMID:21338471
  Authors
Tornquist K
  Title
Sphingosine 1-phosphate, sphingosine kinase and autocrine calcium signalling in thyroid cells.
  Journal
Acta Physiol (Oxf) 204:151-7 (2012)
DOI:10.1111/j.1748-1716.2011.02265.x
Reference
PMID:22129055
  Authors
Feske S
  Title
Immunodeficiency due to defects in store-operated calcium entry.
  Journal
Ann N Y Acad Sci 1238:74-90 (2011)
DOI:10.1111/j.1749-6632.2011.06240.x
Reference
PMID:22002090
  Authors
Giachini FR, Lima VV, Hannan JL, Carneiro FS, Webb RC, Tostes RC
  Title
STIM1/Orai1-mediated store-operated Ca2+ entry: the tip of the iceberg.
  Journal
Braz J Med Biol Res 44:1080-7 (2011)
DOI:10.1590/S0100-879X2011007500133
Reference
PMID:19172794
  Authors
Baba Y, Kurosaki T
  Title
[Regulation of store-operated calcium entry by STIM1].
  Journal
Seikagaku 80:1123-8 (2008)
Reference
PMID:19475418
  Authors
Galione A, Evans AM, Ma J, Parrington J, Arredouani A, Cheng X, Zhu MX
  Title
The acid test: the discovery of two-pore channels (TPCs) as NAADP-gated endolysosomal Ca(2+) release channels.
  Journal
Pflugers Arch 458:869-76 (2009)
DOI:10.1007/s00424-009-0682-y
Reference
PMID:19434403
  Authors
Beard NA, Wei L, Dulhunty AF
  Title
Ca(2+) signaling in striated muscle: the elusive roles of triadin, junctin, and calsequestrin.
  Journal
Eur Biophys J 39:27-36 (2009)
DOI:10.1007/s00249-009-0449-6
Reference
PMID:26228554
  Authors
Marty I
  Title
Triadin regulation of the ryanodine receptor complex.
  Journal
J Physiol 593:3261-6 (2015)
DOI:10.1113/jphysiol.2014.281147
Reference
PMID:20807542
  Authors
Arvanitis DA, Vafiadaki E, Sanoudou D, Kranias EG
  Title
Histidine-rich calcium binding protein: the new regulator of sarcoplasmic reticulum calcium cycling.
  Journal
J Mol Cell Cardiol 50:43-9 (2011)
DOI:10.1016/j.yjmcc.2010.08.021
Related
pathway
zvi04010  MAPK signaling pathway
zvi04070  Phosphatidylinositol signaling system
zvi04210  Apoptosis
KO pathway
ko04020   

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