KEGG    Network variation - Hepatitis C virus (HCV)
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ENTRYnt06163
NameHepatitis C virus (HCV)
CategoryDisease view; Viral infection
Pathwayhsa05160 Hepatitis C
GenomeT40066
DiseaseH00413 Hepatitis C
H00048 Hepatocellular carcinoma
Display drug-target relation   disease type
ERK signaling
N00001    EGF→EGFR→GRB2→SOS→RAS→RAF→MEK→ERK→CCND1
  D1,D2
 |		  
N00274      NS5A⊣GRB2
N00216    HGF→MET→GRB2→SOS→RAS→RAF→MEK→ERK
N00518          Core⊣YWHA⊣RAF→MEK→ERK
N00519              Core→MEK
 
PI3K signaling
N00033    EGF→EGFR→PI3K→PIP3→AKT⊣BAD
  D1,D2
 |		  
N00272      NS5A→PI3K
 
TLR signaling
N00149    TLR3→TICAM1→TRAF3→(IKBKE+TBK1)→IRF3→(CREBBP,EP300)⇒IFNB1
N00516    (NS3,NS4A)⊣TICAM1
N00517          (NS3,NS4A)⊣IRF3
 
RLR signaling
N00469    RNA→RIGI→MAVS→TRAF3→(TANK+NAP1+SINTBAD..→(TBK1+IKBKE)→(IRF7,IRF3)⇒(IFNA,IFNB1)
N00271      (NS3,NS4A)⊣MAVS
 
NLR signaling
N00515      OAS→2-5A→RNASEL
D1,D2
 |		  
N00273    NS5A⊣OAS
 
IFN signaling
N00150    (IFNA,IFNB1)→(IFNAR1+IFNAR2)→(JAK1,TYK2)→(STAT1+STAT2+IRF9)⇒(IRF7,EIF2AK2)
N00270        Core⊣(STAT1+STAT2+IRF9)
 
TNF signaling
N00151    TNF→TNFRSF1A→(RIPK1+TRADD+TRAF2..→(TAB1/2/3+TAK1)→IKK→NFKBIA→NFKB
  D1,D2
 |		  
N00525      NS5A⊣(TRADD+TRAF2)
N00269            Core→NFKB
 
Cell cycle
N00066    CDKN2A⊣MDM2⊣TP53⇒CDKN1A⊣(CCND+CDK4/6)→RB1⌿E2F
N00521      Core⊣TP53
  D1,D2
 |		  
N00520      NS5A⊣TP53
N00522      NS3⊣TP53
N00523        Core⊣CDKN1A
 
Apoptosis
N00145    TNF→TNFRSF1A→(RIPK1+TRADD+TRAF2..→FADD→CASP8→(CASP3,CASP7)
  D1,D2
 |		  
N00524      NS5A⊣TRADD
N00528        Core→CFLAR⊣CASP8
N00146      (FASLG,TNFSF10)→(FAS,TNFRSF10B)→FADD→(CASP8,CASP10)→BID→(BAX,BAK1)→CYCS=APAF1→CASP9→(CASP3,CASP7)
N00527      Core→FAS
N00526          NS3→CASP8
 
Transcription
N00529    Core→(RXRA+PPARA)⇒(CCND1,CDK4,MYC)
N00530    (Core+PSME3)→(RXRA+NR1H3)⇒(CCND1,CDK4,MYC)


Drug name
D1D12744Ravidasvir (USAN/INN)
D2D12745Ravidasvir hydrochloride (USAN)