Entry Name Influenza A - Hipposideros armiger (great roundleaf bat)
Description Influenza is a contagious respiratory disease caused by influenza virus infection. Influenza A virus is responsible for both annual seasonal epidemics and periodic worldwide pandemics. Novel strains that cause pandemics arise from avian influenza virus by genetic reassortment among influenza viruses and two surface glycoproteins HA and NA form the basis of serologically distinct virus types. The innate immune system recognizes invaded virus through multiple mechanisms. Viral non-structural NS1 protein is a multifunctional virulence factor that interfere IFN-mediated antiviral response. It inhibits IFN production by blocking activation of transcription factors such as NF-kappa B and IRF3. NS1 further inhibits the activation of IFN-induced antiviral genes. PB1-F2 protein is another virulence factor that induce apoptosis of infected cells, which results in life-threatening bronchiolitis.
Class Human Diseases; Infectious disease: viralBRITE hierarchy
Pathway map Disease Organism Hipposideros armiger (great roundleaf bat) [GN:
hai ]
Gene 109371673 TNFSF10; tumor necrosis factor ligand superfamily member 10 [KO:K04721 ]
109372325 TNFRSF10A; tumor necrosis factor receptor superfamily member 10A [KO:K04722 ]
109372426 NUP98; nuclear pore complex protein Nup98-Nup96 isoform X1 [KO:K14297 ]
109372541 NFKB1; nuclear factor NF-kappa-B p105 subunit isoform X1 [KO:K02580 ]
109372681 PIK3CA; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform isoform X1 [KO:K00922 ] [EC:2.7.1.153 ]
109373148 IL12A; LOW QUALITY PROTEIN: interleukin-12 subunit alpha [KO:K05406 ]
109373644 TNFRSF1A; tumor necrosis factor receptor superfamily member 1A [KO:K03158 ]
109373811 PIK3R3; phosphatidylinositol 3-kinase regulatory subunit gamma isoform X1 [KO:K02649 ]
109374176 PYCARD; apoptosis-associated speck-like protein containing a CARD [KO:K12799 ]
109375904 TMPRSS11D; transmembrane protease serine 11D isoform X1 [KO:K09641 ] [EC:3.4.21.-]
109376052 NXF3; LOW QUALITY PROTEIN: nuclear RNA export factor 3 [KO:K14284 ]
109376589 HNRNPUL1; heterogeneous nuclear ribonucleoprotein U-like protein 1 isoform X1 [KO:K15047 ]
109377126 FAS; tumor necrosis factor receptor superfamily member 6 [KO:K04390 ]
109377395 NLRP3; NACHT, LRR and PYD domains-containing protein 3 [KO:K12800 ]
109379054 CPSF4; cleavage and polyadenylation specificity factor subunit 4 isoform X1 [KO:K14404 ]
109380813 CALCOCO2; calcium-binding and coiled-coil domain-containing protein 2 isoform X1 [KO:K21348 ]
109381238 PIK3CD; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform [KO:K00922 ] [EC:2.7.1.153 ]
109382061 EIF2S1; eukaryotic translation initiation factor 2 subunit 1 [KO:K03237 ]
109382336 APAF1; apoptotic protease-activating factor 1 isoform X1 [KO:K02084 ]
109382484 PIK3R2; phosphatidylinositol 3-kinase regulatory subunit beta [KO:K02649 ]
109382625 VDAC1; voltage-dependent anion-selective channel protein 1 isoform X1 [KO:K05862 ]
109384704 RSAD2; radical S-adenosyl methionine domain-containing protein 2 [KO:K15045 ]
109385146 FASLG; tumor necrosis factor ligand superfamily member 6 [KO:K04389 ]
109385279 TMPRSS4; transmembrane protease serine 4 isoform X1 [KO:K09635 ] [EC:3.4.21.-]
109387207 CPSF4L; putative cleavage and polyadenylation specificity factor subunit 4-like protein isoform X1 [KO:K14404 ]
109389566 NXF5; LOW QUALITY PROTEIN: nuclear RNA export factor 5 [KO:K14284 ]
109390108 TRADD; tumor necrosis factor receptor type 1-associated DEATH domain protein isoform X1 [KO:K03171 ]
109393276 STAT1; signal transducer and activator of transcription 1-alpha/beta [KO:K11220 ]
109393491 MYD88; myeloid differentiation primary response protein MyD88 [KO:K04729 ]
109394108 PIK3CB; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform [KO:K00922 ] [EC:2.7.1.153 ]
109395865 PIK3R1; phosphatidylinositol 3-kinase regulatory subunit alpha isoform X1 [KO:K02649 ]
109396910 STAT2; signal transducer and activator of transcription 2 isoform X1 [KO:K11221 ]
Compound C05981 Phosphatidylinositol-3,4,5-trisphosphate
Reference Authors Edinger TO, Pohl MO, Stertz S
Title Entry of influenza A virus: host factors and antiviral targets.
Journal Reference Authors Kido H, Okumura Y, Takahashi E, Pan HY, Wang S, Chida J, Le TQ, Yano M
Title Host envelope glycoprotein processing proteases are indispensable for entry into human cells by seasonal and highly pathogenic avian influenza viruses.
Journal J Mol Genet Med 3:167-75 (2008)
Reference Authors Ramakrishnan B, Viswanathan K, Tharakaraman K, Dancik V, Raman R, Babcock GJ, Shriver Z, Sasisekharan R
Title A Structural and Mathematical Modeling Analysis of the Likelihood of Antibody-Dependent Enhancement in Influenza.
Journal Reference Authors Thanh TT, van Doorn HR, de Jong MD
Title Human H5N1 influenza: current insight into pathogenesis.
Journal Reference Authors Michael P, Brabant D, Bleiblo F, Ramana CV, Rutherford M, Khurana S, Tai TC, Kumar A, Kumar A
Title Influenza A induced cellular signal transduction pathways.
Journal Reference Authors Hale BG, Albrecht RA, Garcia-Sastre A
Title Innate immune evasion strategies of influenza viruses.
Journal Reference Authors Sharma K, Tripathi S, Ranjan P, Kumar P, Garten R, Deyde V, Katz JM, Cox NJ, Lal RB, Sambhara S, Lal SK
Title Influenza A virus nucleoprotein exploits Hsp40 to inhibit PKR activation.
Journal Reference Authors Ehrhardt C, Seyer R, Hrincius ER, Eierhoff T, Wolff T, Ludwig S
Title Interplay between influenza A virus and the innate immune signaling.
Journal Reference Authors van de Sandt CE, Kreijtz JH, Rimmelzwaan GF
Title Evasion of influenza A viruses from innate and adaptive immune responses.
Journal Reference Authors Long JS, Mistry B, Haslam SM, Barclay WS
Title Host and viral determinants of influenza A virus species specificity.
Journal Reference Authors Chen X, Liu S, Goraya MU, Maarouf M, Huang S, Chen JL
Title Host Immune Response to Influenza A Virus Infection.
Journal Reference Authors Lu X, Masic A, Li Y, Shin Y, Liu Q, Zhou Y
Title The PI3K/Akt pathway inhibits influenza A virus-induced Bax-mediated apoptosis by negatively regulating the JNK pathway via ASK1.
Journal Reference Authors Ichinohe T, Iwasaki A, Hasegawa H
Title Innate sensors of influenza virus: clues to developing better intranasal vaccines.
Journal Reference Authors Le Sage V, Cinti A, Amorim R, Mouland AJ
Title Adapting the Stress Response: Viral Subversion of the mTOR Signaling Pathway.
Journal Reference Authors Fan Y, Sanyal S, Bruzzone R
Title Breaking Bad: How Viruses Subvert the Cell Cycle.
Journal Reference Authors Varga ZT, Palese P
Title The influenza A virus protein PB1-F2: killing two birds with one stone?
Journal Reference Authors Atkin-Smith GK, Duan M, Chen W, Poon IKH
Title The induction and consequences of Influenza A virus-induced cell death.
Journal Reference Authors Nogales A, Martinez-Sobrido L, Topham DJ, DeDiego ML
Title Modulation of Innate Immune Responses by the Influenza A NS1 and PA-X Proteins.
Journal Reference Authors Dai X, Zhang L, Hong T
Title Host cellular signaling induced by influenza virus.
Journal Reference Authors Li J, Yu M, Zheng W, Liu W
Title Nucleocytoplasmic shuttling of influenza A virus proteins.
Journal Reference Authors Dou D, Revol R, Ostbye H, Wang H, Daniels R
Title Influenza A Virus Cell Entry, Replication, Virion Assembly and Movement.
Journal Reference Authors Paterson D, Fodor E
Title Emerging roles for the influenza A virus nuclear export protein (NEP).
Journal Related hai00900 Terpenoid backbone biosynthesis
hai04620 Toll-like receptor signaling pathway
hai04621 NOD-like receptor signaling pathway
hai04622 RIG-I-like receptor signaling pathway
KO pathway
