Entry Name Influenza A - Buteo buteo (common buzzard)
Description Influenza is a contagious respiratory disease caused by influenza virus infection. Influenza A virus is responsible for both annual seasonal epidemics and periodic worldwide pandemics. Novel strains that cause pandemics arise from avian influenza virus by genetic reassortment among influenza viruses and two surface glycoproteins HA and NA form the basis of serologically distinct virus types. The innate immune system recognizes invaded virus through multiple mechanisms. Viral non-structural NS1 protein is a multifunctional virulence factor that interfere IFN-mediated antiviral response. It inhibits IFN production by blocking activation of transcription factors such as NF-kappa B and IRF3. NS1 further inhibits the activation of IFN-induced antiviral genes. PB1-F2 protein is another virulence factor that induce apoptosis of infected cells, which results in life-threatening bronchiolitis.
Class Human Diseases; Infectious disease: viralBRITE hierarchy
Pathway map Disease Organism Buteo buteo (common buzzard) [GN:
bbut ]
Gene 142025801 IKBKG; LOW QUALITY PROTEIN: NF-kappa-B essential modulator [KO:K07210 ]
142026508 HNRNPUL1; heterogeneous nuclear ribonucleoprotein U-like protein 1 [KO:K15047 ]
142026878 PIK3R1; phosphatidylinositol 3-kinase regulatory subunit alpha isoform X1 [KO:K02649 ]
142030217 FAS; tumor necrosis factor receptor superfamily member 6 isoform X1 [KO:K04390 ]
142030878 PIK3CD; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform isoform X1 [KO:K00922 ] [EC:2.7.1.153 ]
142031114 STAT1; signal transducer and activator of transcription 1-alpha/beta isoform X1 [KO:K11220 ]
142031319 IFIH1; interferon-induced helicase C domain-containing protein 1 isoform X1 [KO:K12647 ] [EC:5.6.2.6 ]
142032104 NFKBIA; LOW QUALITY PROTEIN: NF-kappa-B inhibitor alpha [KO:K04734 ]
142032167 EIF2S1; eukaryotic translation initiation factor 2 subunit 1 [KO:K03237 ]
142032597 TNFSF10; tumor necrosis factor ligand superfamily member 10 isoform X1 [KO:K04721 ]
142032606 PIK3CA; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform [KO:K00922 ] [EC:2.7.1.153 ]
142032795 NFKB1; nuclear factor NF-kappa-B p105 subunit isoform X1 [KO:K02580 ]
142032803 PIK3CB; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform [KO:K00922 ] [EC:2.7.1.153 ]
142033891 TNFRSF1A; tumor necrosis factor receptor superfamily member 1A isoform X1 [KO:K03158 ]
142034700 CALCOCO2; calcium-binding and coiled-coil domain-containing protein 2 isoform X1 [KO:K21348 ]
142034919 TMPRSS4; transmembrane protease serine 4 [KO:K09635 ] [EC:3.4.21.-]
142035176 PIK3R3; phosphatidylinositol 3-kinase regulatory subunit gamma isoform X1 [KO:K02649 ]
142035424 FASLG; tumor necrosis factor ligand superfamily member 6 [KO:K04389 ]
142035664 PIK3R2; phosphatidylinositol 3-kinase regulatory subunit beta [KO:K02649 ]
142036551 PABPN1L; embryonic polyadenylate-binding protein 2 isoform X1 [KO:K14396 ]
142038078 EIF2AK2; interferon-induced, double-stranded RNA-activated protein kinase isoform X1 [KO:K16195 ] [EC:2.7.11.1 ]
142038643 CPSF4L; putative cleavage and polyadenylation specificity factor subunit 4-like protein [KO:K14404 ]
142038801 MYD88; myeloid differentiation primary response protein MyD88 [KO:K04729 ]
142040866 RSAD2; S-adenosylmethionine-dependent nucleotide dehydratase RSAD2 [KO:K15045 ]
142041094 STAT2; signal transducer and activator of transcription 2 [KO:K11221 ]
142041469 NUP98; nuclear pore complex protein Nup98-Nup96 isoform X1 [KO:K14297 ]
142044978 APAF1; apoptotic protease-activating factor 1 isoform X1 [KO:K02084 ]
142045416 CPSF4; cleavage and polyadenylation specificity factor subunit 4 [KO:K14404 ]
Compound C05981 Phosphatidylinositol-3,4,5-trisphosphate
Reference Authors Edinger TO, Pohl MO, Stertz S
Title Entry of influenza A virus: host factors and antiviral targets.
Journal Reference Authors Kido H, Okumura Y, Takahashi E, Pan HY, Wang S, Chida J, Le TQ, Yano M
Title Host envelope glycoprotein processing proteases are indispensable for entry into human cells by seasonal and highly pathogenic avian influenza viruses.
Journal J Mol Genet Med 3:167-75 (2008)
Reference Authors Ramakrishnan B, Viswanathan K, Tharakaraman K, Dancik V, Raman R, Babcock GJ, Shriver Z, Sasisekharan R
Title A Structural and Mathematical Modeling Analysis of the Likelihood of Antibody-Dependent Enhancement in Influenza.
Journal Reference Authors Thanh TT, van Doorn HR, de Jong MD
Title Human H5N1 influenza: current insight into pathogenesis.
Journal Reference Authors Michael P, Brabant D, Bleiblo F, Ramana CV, Rutherford M, Khurana S, Tai TC, Kumar A, Kumar A
Title Influenza A induced cellular signal transduction pathways.
Journal Reference Authors Hale BG, Albrecht RA, Garcia-Sastre A
Title Innate immune evasion strategies of influenza viruses.
Journal Reference Authors Sharma K, Tripathi S, Ranjan P, Kumar P, Garten R, Deyde V, Katz JM, Cox NJ, Lal RB, Sambhara S, Lal SK
Title Influenza A virus nucleoprotein exploits Hsp40 to inhibit PKR activation.
Journal Reference Authors Ehrhardt C, Seyer R, Hrincius ER, Eierhoff T, Wolff T, Ludwig S
Title Interplay between influenza A virus and the innate immune signaling.
Journal Reference Authors van de Sandt CE, Kreijtz JH, Rimmelzwaan GF
Title Evasion of influenza A viruses from innate and adaptive immune responses.
Journal Reference Authors Long JS, Mistry B, Haslam SM, Barclay WS
Title Host and viral determinants of influenza A virus species specificity.
Journal Reference Authors Chen X, Liu S, Goraya MU, Maarouf M, Huang S, Chen JL
Title Host Immune Response to Influenza A Virus Infection.
Journal Reference Authors Lu X, Masic A, Li Y, Shin Y, Liu Q, Zhou Y
Title The PI3K/Akt pathway inhibits influenza A virus-induced Bax-mediated apoptosis by negatively regulating the JNK pathway via ASK1.
Journal Reference Authors Ichinohe T, Iwasaki A, Hasegawa H
Title Innate sensors of influenza virus: clues to developing better intranasal vaccines.
Journal Reference Authors Le Sage V, Cinti A, Amorim R, Mouland AJ
Title Adapting the Stress Response: Viral Subversion of the mTOR Signaling Pathway.
Journal Reference Authors Fan Y, Sanyal S, Bruzzone R
Title Breaking Bad: How Viruses Subvert the Cell Cycle.
Journal Reference Authors Varga ZT, Palese P
Title The influenza A virus protein PB1-F2: killing two birds with one stone?
Journal Reference Authors Atkin-Smith GK, Duan M, Chen W, Poon IKH
Title The induction and consequences of Influenza A virus-induced cell death.
Journal Reference Authors Nogales A, Martinez-Sobrido L, Topham DJ, DeDiego ML
Title Modulation of Innate Immune Responses by the Influenza A NS1 and PA-X Proteins.
Journal Reference Authors Dai X, Zhang L, Hong T
Title Host cellular signaling induced by influenza virus.
Journal Reference Authors Li J, Yu M, Zheng W, Liu W
Title Nucleocytoplasmic shuttling of influenza A virus proteins.
Journal Reference Authors Dou D, Revol R, Ostbye H, Wang H, Daniels R
Title Influenza A Virus Cell Entry, Replication, Virion Assembly and Movement.
Journal Reference Authors Paterson D, Fodor E
Title Emerging roles for the influenza A virus nuclear export protein (NEP).
Journal Related bbut04620 Toll-like receptor signaling pathway
bbut04621 NOD-like receptor signaling pathway
bbut04622 RIG-I-like receptor signaling pathway
KO pathway
