KEGG   PATHWAY: elk04062
Entry
elk04062                    Pathway                                
Name
Chemokine signaling pathway - Enhydra lutris kenyoni (northern sea otter)
Description
Inflammatory immune response requires the recruitment of leukocytes to the site of inflammation upon foreign insult. Chemokines are small chemoattractant peptides that provide directional cues for the cell trafficking and thus are vital for protective host response. In addition, chemokines regulate plethora of biological processes of hematopoietic cells to lead cellular activation, differentiation and survival.
The chemokine signal is transduced by chemokine receptors (G-protein coupled receptors) expressed on the immune cells. After receptor activation, the alpha- and beta-gamma-subunits of G protein dissociate to activate diverse downstream pathways resulting in cellular polarization and actin reorganization. Various members of small GTPases are involved in this process. Induction of nitric oxide and production of reactive oxygen species are as well regulated by chemokine signal via calcium mobilization and diacylglycerol production.
Class
Organismal Systems; Immune system
Pathway map
elk04062  Chemokine signaling pathway
elk04062

Other DBs
GO: 0070098
Organism
Enhydra lutris kenyoni (northern sea otter) [GN:elk]
Gene
111148819  growth-regulated protein homolog gamma-like [KO:K05505]
111149266  LOW QUALITY PROTEIN: growth-regulated alpha protein-like [KO:K05505]
111149323  alveolar macrophage chemotactic factor-like [KO:K05506]
111149250  platelet basic protein-like [KO:K10029]
111149115  interleukin-8 [KO:K10030]
111149152  C-X-C motif chemokine 9 [KO:K05416]
111149252  C-X-C motif chemokine 10 [KO:K12671]
111149304  C-X-C motif chemokine 11 [KO:K12672]
111145109  stromal cell-derived factor 1 isoform X1 [KO:K10031]
111149300  C-X-C motif chemokine 13 [KO:K10032]
111161225  C-X-C motif chemokine 16 [KO:K10035]
111141178  C-X-C motif chemokine 14 [KO:K10033]
111157376  fractalkine [KO:K05508]
111151227  C-C motif chemokine 1 [KO:K05514]
111151532  C-C motif chemokine 2 [KO:K14624]
111151630  C-C motif chemokine 3 [KO:K05408]
111151681  C-C motif chemokine 3-like [KO:K05408]
111151720  regakine-1-like [KO:K05408]
111151525  C-C motif chemokine 4 isoform X1 [KO:K12964]
111151516  C-C motif chemokine 5 [KO:K12499]
111151713  C-C motif chemokine 2-like isoform X1 [KO:K05509]
111151717  C-C motif chemokine 8-like isoform X1 [KO:K16596]
111151445  LOW QUALITY PROTEIN: C-C motif chemokine 13-like [KO:K16595]
111151646  C-C motif chemokine 14 [KO:K21092]
111151583  C-C motif chemokine 15 isoform X1 [KO:K05511]
111151207  C-C motif chemokine 16 [KO:K21093]
111157422  C-C motif chemokine 17 [KO:K21083]
111146036  C-C motif chemokine 19 [KO:K05512]
111144686  C-C motif chemokine 20 isoform X1 [KO:K14625]
111145903  C-C motif chemokine 21 isoform X1 [KO:K16062]
111157393  C-C motif chemokine 22 [KO:K21095]
111161639  C-C motif chemokine 25 [KO:K13072]
111145534  C-C motif chemokine 26 [KO:K21096]
111145853  C-C motif chemokine 27 [KO:K16598]
111145854  uncharacterized protein LOC111145854 [KO:K16598]
111141228  C-C motif chemokine 28 [KO:K05513]
111145052  C-X-C chemokine receptor type 2 [KO:K05050]
111144916  C-X-C chemokine receptor type 2-like [KO:K04175]
111161027  C-X-C chemokine receptor type 3 [KO:K04188]
111145588  C-X-C chemokine receptor type 4 isoform X1 [KO:K04189]
111153765  C-X-C chemokine receptor type 5 isoform X1 [KO:K04190]
111144048  C-X-C chemokine receptor type 6 [KO:K04191]
111144216  chemokine XC receptor 1 [KO:K04193]
111159134  CX3C chemokine receptor 1 [KO:K04192]
111159160  C-C chemokine receptor type 8 [KO:K04183]
111158673  C-C chemokine receptor type 6 [KO:K04181]
111144184  C-C chemokine receptor type 9 [KO:K04184]
111159151  C-C chemokine receptor type 4 [KO:K04179]
111151380  C-C chemokine receptor type 7 [KO:K04182]
111144089  C-C chemokine receptor type 2 [KO:K04177]
111143981  C-C chemokine receptor type 5 [KO:K04180]
111143875  C-C chemokine receptor type 1-like [KO:K04176]
111144227  C-C chemokine receptor type 3 [KO:K04178]
111151810  C-C chemokine receptor type 10 [KO:K04185]
111153517  tyrosine-protein kinase JAK2 [KO:K04447] [EC:2.7.10.2]
111143876  tyrosine-protein kinase JAK3 isoform X1 [KO:K11218] [EC:2.7.10.2]
111144592  signal transducer and activator of transcription 1-alpha/beta isoform X1 [KO:K11220]
111160141  signal transducer and activator of transcription 2 isoform X1 [KO:K11221]
111151241  signal transducer and activator of transcription 3 isoform X1 [KO:K04692]
111151253  signal transducer and activator of transcription 5B [KO:K11224]
111155312  guanine nucleotide-binding protein G(i) subunit alpha-1 [KO:K04630]
111143783  guanine nucleotide-binding protein G(i) subunit alpha-2 [KO:K04630]
111143343  guanine nucleotide-binding protein G(k) subunit alpha [KO:K04630]
111157054  adenylate cyclase type 1 [KO:K08041] [EC:4.6.1.1]
111153427  adenylate cyclase type 2 [KO:K08042] [EC:4.6.1.1]
111154044  adenylate cyclase type 3 isoform X1 [KO:K08043] [EC:4.6.1.1]
111162403  adenylate cyclase type 4 isoform X1 [KO:K08044] [EC:4.6.1.1]
111155044  adenylate cyclase type 5 [KO:K08045] [EC:4.6.1.1]
111157825  adenylate cyclase type 6 [KO:K08046] [EC:4.6.1.1]
111157326  adenylate cyclase type 7 isoform X1 [KO:K08047] [EC:4.6.1.1]
111146667  adenylate cyclase type 8 [KO:K08048] [EC:4.6.1.1]
111156133  adenylate cyclase type 9 [KO:K08049] [EC:4.6.1.1]
111162516  cAMP-dependent protein kinase catalytic subunit alpha isoform X1 [KO:K04345] [EC:2.7.11.11]
111143399  cAMP-dependent protein kinase catalytic subunit beta isoform X1 [KO:K04345] [EC:2.7.11.11]
111155370  tyrosine-protein kinase Lyn isoform X1 [KO:K05854] [EC:2.7.10.2]
111141509  tyrosine-protein kinase HCK isoform X1 [KO:K08893] [EC:2.7.10.2]
111142853  tyrosine-protein kinase Fgr [KO:K08891] [EC:2.7.10.2]
111141563  proto-oncogene tyrosine-protein kinase Src [KO:K05704] [EC:2.7.10.2]
111138866  SHC-transforming protein 1 isoform X1 [KO:K06279]
111161808  SHC-transforming protein 2 [KO:K17447]
111153623  SHC-transforming protein 3 [KO:K17448]
111162137  SHC-transforming protein 4 [KO:K17449]
111160411  growth factor receptor-bound protein 2 [KO:K04364]
111158354  son of sevenless homolog 1 isoform X1 [KO:K03099]
111160889  son of sevenless homolog 2 isoform X1 [KO:K03099]
111140316  GTPase HRas isoform X1 [KO:K02833]
111159984  GTPase KRas isoform X1 [KO:K07827]
111143238  GTPase NRas [KO:K07828]
111144322  RAF proto-oncogene serine/threonine-protein kinase isoform X1 [KO:K04366] [EC:2.7.11.1]
111151941  serine/threonine-protein kinase B-raf isoform X1 [KO:K04365] [EC:2.7.11.1]
111153158  dual specificity mitogen-activated protein kinase kinase 1 [KO:K04368] [EC:2.7.12.2]
111162236  LOW QUALITY PROTEIN: mitogen-activated protein kinase 3 [KO:K04371] [EC:2.7.11.24]
111142759  mitogen-activated protein kinase 1 [KO:K04371] [EC:2.7.11.24]
111155003  LOW QUALITY PROTEIN: phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform [KO:K00922] [EC:2.7.1.153]
111147545  phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform [KO:K00922] [EC:2.7.1.153]
111154641  phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform isoform X1 [KO:K00922] [EC:2.7.1.153]
111143470  phosphatidylinositol 3-kinase regulatory subunit gamma isoform X1 [KO:K02649]
111155224  phosphatidylinositol 3-kinase regulatory subunit alpha isoform X1 [KO:K02649]
111143790  phosphatidylinositol 3-kinase regulatory subunit beta [KO:K02649]
111155215  phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform [KO:K21289] [EC:2.7.1.153]
111161090  phosphoinositide 3-kinase regulatory subunit 6 [KO:K21290]
111161150  phosphoinositide 3-kinase regulatory subunit 5 [KO:K21290]
111154565  protein kinase C zeta type isoform X1 [KO:K18952] [EC:2.7.11.13]
111161374  RAC-beta serine/threonine-protein kinase [KO:K04456] [EC:2.7.11.1]
111148765  RAC-alpha serine/threonine-protein kinase isoform X1 [KO:K04456] [EC:2.7.11.1]
111150885  RAC-gamma serine/threonine-protein kinase isoform X1 [KO:K04456] [EC:2.7.11.1]
111158279  forkhead box protein O3 [KO:K09408]
111144921  inhibitor of nuclear factor kappa-B kinase subunit alpha isoform X1 [KO:K04467] [EC:2.7.11.10]
111144397  inhibitor of nuclear factor kappa-B kinase subunit beta isoform X1 [KO:K07209] [EC:2.7.11.10]
111139191  NF-kappa-B essential modulator [KO:K07210]
111140276  NF-kappa-B inhibitor alpha isoform X1 [KO:K04734]
111161594  NF-kappa-B inhibitor beta [KO:K02581]
111153611  nuclear factor NF-kappa-B p105 subunit isoform X1 [KO:K02580]
111149956  transcription factor p65 [KO:K04735]
111149975  bcl2-associated agonist of cell death [KO:K02158]
111139521  glycogen synthase kinase-3 alpha isoform X1 [KO:K08822] [EC:2.7.11.26]
111149921  glycogen synthase kinase-3 beta isoform X1 [KO:K03083] [EC:2.7.11.26]
111140995  tyrosine-protein kinase ITK/TSK [KO:K07363] [EC:2.7.10.2]
111146429  guanine nucleotide exchange factor VAV2 isoform X1 [KO:K05730]
111161665  proto-oncogene vav isoform X1 [KO:K05730]
111142837  guanine nucleotide exchange factor VAV3 [KO:K05730]
111145636  ras-related C3 botulinum toxin substrate 1 isoform X1 [KO:K04392]
111157484  ras-related C3 botulinum toxin substrate 2 [KO:K07860]
111160304  ras-related C3 botulinum toxin substrate 3 isoform X1 [KO:K07861]
111154419  serine/threonine-protein kinase PAK 1 [KO:K04409] [EC:2.7.11.1]
111154823  cell division control protein 42 homolog isoform X1 [KO:K04393]
111150530  wiskott-Aldrich syndrome protein [KO:K05747]
111144026  transforming protein RhoA isoform X1 [KO:K04513]
111142435  rho-associated protein kinase 1 isoform X1 [KO:K04514] [EC:2.7.11.1]
111154090  rho-associated protein kinase 2 isoform X1 [KO:K17388] [EC:2.7.11.1]
111154601  guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1 [KO:K04536]
111145586  guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-2 isoform X1 [KO:K04537]
111159773  guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-3 [KO:K07825]
111148588  guanine nucleotide-binding protein subunit beta-4 [KO:K04538]
111140421  guanine nucleotide-binding protein subunit beta-5 [KO:K04539]
111159618  guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2 isoform X1 [KO:K07826]
111149566  guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-3 [KO:K04540]
111160502  guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-4 [KO:K04541]
111143000  guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-5 [KO:K04542]
111161718  guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-7 [KO:K04543]
111160835  guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-8 [KO:K04544]
111145828  guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-10 [KO:K04545]
111147333  guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-11 [KO:K04546]
111162432  uncharacterized LOC105372280 homolog [KO:K04347]
111142967  guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-12 [KO:K04347]
111156207  guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-13 [KO:K04547]
111147281  guanine nucleotide-binding protein G(T) subunit gamma-T1 [KO:K04548]
111151818  guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-T2 [KO:K04549]
111141372  phosphatidylinositol 3,4,5-trisphosphate-dependent Rac exchanger 1 protein isoform X1 [KO:K12365]
111147268  engulfment and cell motility protein 1 isoform X1 [KO:K12366]
111140871  dedicator of cytokinesis protein 2 [KO:K12367]
111146744  focal adhesion kinase 1 isoform X1 [KO:K05725] [EC:2.7.10.2]
111156467  paxillin [KO:K05760]
111152853  breast cancer anti-estrogen resistance protein 1 isoform X1 [KO:K05726]
111151533  adapter molecule crk isoform X1 [KO:K04438]
111142678  crk-like protein isoform X1 [KO:K04438]
111153692  protein-tyrosine kinase 2-beta isoform X1 [KO:K05871] [EC:2.7.10.2]
111153498  guanine nucleotide-binding protein G(q) subunit alpha [KO:K04634]
111141432  1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-1 [KO:K05858] [EC:3.1.4.11]
111162302  1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-2 isoform X1 [KO:K05858] [EC:3.1.4.11]
111141620  1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-4 isoform X1 [KO:K05858] [EC:3.1.4.11]
111150005  1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-3 isoform X1 [KO:K05858] [EC:3.1.4.11]
111141423  1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1 isoform X1 [KO:K01116] [EC:3.1.4.11]
111152978  1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-2 isoform X1 [KO:K05859] [EC:3.1.4.11]
111149468  RAS guanyl-releasing protein 2 isoform X1 [KO:K12361]
111143648  ras-related protein Rap-1A isoform X1 [KO:K04353]
111141969  ras-related protein Rap-1b [KO:K07836]
111155563  partitioning defective 3 homolog isoform X1 [KO:K04237]
111155650  T-lymphoma invasion and metastasis-inducing protein 1 isoform X1 [KO:K05731]
111162208  protein kinase C beta type isoform X1 [KO:K19662] [EC:2.7.11.13]
111144045  protein kinase C delta type [KO:K06068] [EC:2.7.11.13]
111145864  neutrophil cytosol factor 1 [KO:K08011]
111147107  rhodopsin kinase [KO:K00909] [EC:2.7.11.14]
111151154  rhodopsin kinase [KO:K00909] [EC:2.7.11.14]
111160050  beta-adrenergic receptor kinase 2 isoform X1 [KO:K00910] [EC:2.7.11.15]
111149447  beta-adrenergic receptor kinase 1 [KO:K00910] [EC:2.7.11.15]
111144787  G protein-coupled receptor kinase 5 [KO:K08291] [EC:2.7.11.16]
111140814  G protein-coupled receptor kinase 6 isoform X1 [KO:K08291] [EC:2.7.11.16]
111148957  G protein-coupled receptor kinase 4 isoform X1 [KO:K08291] [EC:2.7.11.16]
111161165  beta-arrestin-2 isoform X1 [KO:K04439]
111159444  beta-arrestin-1 isoform X1 [KO:K04439]
Compound
C00076  Calcium cation
C00165  Diacylglycerol
C00575  3',5'-Cyclic AMP
C01245  D-myo-Inositol 1,4,5-trisphosphate
C05981  Phosphatidylinositol-3,4,5-trisphosphate
Reference
PMID:12495636
  Authors
Wong MM, Fish EN
  Title
Chemokines: attractive mediators of the immune response.
  Journal
Semin Immunol 15:5-14 (2003)
DOI:10.1016/S1044-5323(02)00123-9
Reference
PMID:11872087
  Authors
Curnock AP, Logan MK, Ward SG
  Title
Chemokine signalling: pivoting around multiple phosphoinositide 3-kinases.
  Journal
Immunology 105:125-36 (2002)
DOI:10.1046/j.1365-2567.2002.01345.x
Reference
PMID:12069927
  Authors
Olson TS, Ley K
  Title
Chemokines and chemokine receptors in leukocyte trafficking.
  Journal
Am J Physiol Regul Integr Comp Physiol 283:R7-28 (2002)
DOI:10.1152/ajpregu.00738.2001
Reference
PMID:17169327
  Authors
Busillo JM, Benovic JL
  Title
Regulation of CXCR4 signaling.
  Journal
Biochim Biophys Acta 1768:952-63 (2007)
DOI:10.1016/j.bbamem.2006.11.002
Reference
PMID:11244042
  Authors
Mellado M, Rodriguez-Frade JM, Manes S, Martinez-A C
  Title
Chemokine signaling and functional responses: the role of receptor dimerization and TK pathway activation.
  Journal
Annu Rev Immunol 19:397-421 (2001)
DOI:10.1146/annurev.immunol.19.1.397
Reference
PMID:8576262
  Authors
Knall C, Young S, Nick JA, Buhl AM, Worthen GS, Johnson GL
  Title
Interleukin-8 regulation of the Ras/Raf/mitogen-activated protein kinase pathway in human neutrophils.
  Journal
J Biol Chem 271:2832-8 (1996)
DOI:10.1074/jbc.271.5.2832
Reference
PMID:17537990
  Authors
Patrussi L, Ulivieri C, Lucherini OM, Paccani SR, Gamberucci A, Lanfrancone L, Pelicci PG, Baldari CT
  Title
p52Shc is required for CXCR4-dependent signaling and chemotaxis in T cells.
  Journal
Blood 110:1730-8 (2007)
DOI:10.1182/blood-2007-01-068411
Reference
PMID:18662984
  Authors
Sai J, Raman D, Liu Y, Wikswo J, Richmond A
  Title
Parallel phosphatidylinositol 3-kinase (PI3K)-dependent and Src-dependent pathways lead to CXCL8-mediated Rac2 activation and chemotaxis.
  Journal
J Biol Chem 283:26538-47 (2008)
DOI:10.1074/jbc.M805611200
Reference
PMID:10852130
  Authors
Hauck CR, Klingbeil CK, Schlaepfer DD
  Title
Focal adhesion kinase functions as a receptor-proximal signaling component required for directed cell migration.
  Journal
Immunol Res 21:293-303 (2000)
DOI:10.1385/IR:21:2-3:293
Reference
PMID:14625285
  Authors
Chandrasekar B, Bysani S, Mummidi S
  Title
CXCL16 signals via Gi, phosphatidylinositol 3-kinase, Akt, I kappa B kinase, and nuclear factor-kappa B and induces cell-cell adhesion and aortic smooth muscle cell proliferation.
  Journal
J Biol Chem 279:3188-96 (2004)
DOI:10.1074/jbc.M311660200
Reference
PMID:17371236
  Authors
Smith L, Webb A, Ward SG
  Title
T-lymphocyte navigation and migration: beyond the PI3K paradigm.
  Journal
Biochem Soc Trans 35:193-8 (2007)
DOI:10.1042/BST0350193
Reference
PMID:16144840
  Authors
Huttenrauch F, Pollok-Kopp B, Oppermann M
  Title
G protein-coupled receptor kinases promote phosphorylation and beta-arrestin-mediated internalization of CCR5 homo- and hetero-oligomers.
  Journal
J Biol Chem 280:37503-15 (2005)
DOI:10.1074/jbc.M500535200
Reference
PMID:18711432
  Authors
Thelen M, Stein JV
  Title
How chemokines invite leukocytes to dance.
  Journal
Nat Immunol 9:953-9 (2008)
DOI:10.1038/ni.f.207
Reference
PMID:19159344
  Authors
Ward SG, Marelli-Berg FM
  Title
Mechanisms of chemokine and antigen-dependent T-lymphocyte navigation.
  Journal
Biochem J 418:13-27 (2009)
DOI:10.1042/BJ20081969
Reference
PMID:15803148
  Authors
Schwartzberg PL, Finkelstein LD, Readinger JA
  Title
TEC-family kinases: regulators of T-helper-cell differentiation.
  Journal
Nat Rev Immunol 5:284-95 (2005)
DOI:10.1038/nri1591
Reference
PMID:15771581
  Authors
Berg LJ, Finkelstein LD, Lucas JA, Schwartzberg PL.
  Title
Tec family kinases in T lymphocyte development and function.
  Journal
Annu Rev Immunol 23:549-600 (2005)
DOI:10.1146/annurev.immunol.22.012703.104743
Reference
PMID:17496928
  Authors
Ticchioni M, Essafi M, Jeandel PY, Davi F, Cassuto JP, Deckert M, Bernard A
  Title
Homeostatic chemokines increase survival of B-chronic lymphocytic leukemia cells through inactivation of transcription factor FOXO3a.
  Journal
Oncogene 26:7081-91 (2007)
DOI:10.1038/sj.onc.1210519
Reference
PMID:9765254
  Authors
Korchak HM, Rossi MW, Kilpatrick LE
  Title
Selective role for beta-protein kinase C in signaling for O-2 generation but not degranulation or adherence in differentiated HL60 cells.
  Journal
J Biol Chem 273:27292-9 (1998)
DOI:10.1074/jbc.273.42.27292
Reference
PMID:15046611
  Authors
Johnson Z, Power CA, Weiss C, Rintelen F, Ji H, Ruckle T, Camps M, Wells TN, Schwarz MK, Proudfoot AE, Rommel C
  Title
Chemokine inhibition--why, when, where, which and how?
  Journal
Biochem Soc Trans 32:366-77 (2004)
DOI:10.1042/bst0320366
Reference
PMID:12051620
  Authors
Zhelev DV, Alteraifi A
  Title
Signaling in the motility responses of the human neutrophil.
  Journal
Ann Biomed Eng 30:356-70 (2002)
DOI:10.1114/1.1477446
Reference
PMID:17675482
  Authors
Bach TL, Chen QM, Kerr WT, Wang Y, Lian L, Choi JK, Wu D, Kazanietz MG, Koretzky GA, Zigmond S, Abrams CS
  Title
Phospholipase cbeta is critical for T cell chemotaxis.
  Journal
J Immunol 179:2223-7 (2007)
DOI:10.4049/jimmunol.179.4.2223
Reference
PMID:14607270
  Authors
Hornstein I, Alcover A, Katzav S
  Title
Vav proteins, masters of the world of cytoskeleton organization.
  Journal
Cell Signal 16:1-11 (2004)
DOI:10.1016/S0898-6568(03)00110-4
Related
pathway
elk04010  MAPK signaling pathway
elk04060  Cytokine-cytokine receptor interaction
elk04120  Ubiquitin mediated proteolysis
elk04630  JAK-STAT signaling pathway
elk04670  Leukocyte transendothelial migration
elk04810  Regulation of actin cytoskeleton
KO pathway
ko04062   
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