KEGG   PATHWAY: elk05167
Entry
elk05167                    Pathway                                
Name
Kaposi sarcoma-associated herpesvirus infection - Enhydra lutris kenyoni (northern sea otter)
Description
Kaposi sarcoma-associated herpesvirus (KSHV), also known as human herpesvirus 8 (HHV-8), is the most recently identified human tumor virus, and is associated with the pathogenesis of Kaposi's sarcoma (KS), primary effusion lymphoma (PEL), and Multicentric Castleman's disease (MCD). Like all other herpesviruses, KSHV displays two modes of life cycle, latency and lytic replication, which are characterized by the patterns of viral gene expression. Genes expressed in latency (LANA, v-cyclin, v-FLIP, Kaposins A, B and C and viral miRNAs) are mainly thought to facilitate the establishment of life long latency in its host and survival against the host innate, and adaptive immune surveillance mechanisms. Among the viral proteins shown to be expressed during lytic replication are potent signaling molecules such as vGPCR, vIL6, vIRFs, vCCLs, K1 and K15, which have been implicated experimentally in the angiogenic and inflammatory phenotype observed in KS lesions. Several of these latent viral and lytic proteins are known to transform host cells, linking KSHV with the development of severe human malignancies.
Class
Human Diseases; Infectious disease: viral
Pathway map
elk05167  Kaposi sarcoma-associated herpesvirus infection
elk05167

Organism
Enhydra lutris kenyoni (northern sea otter) [GN:elk]
Gene
111161841  complement C3 [KO:K03990]
111144566  toll-like receptor 3 [KO:K05401]
111161725  TIR domain-containing adapter molecule 1 [KO:K05842]
111148495  TNF receptor-associated factor 3 isoform X1 [KO:K03174]
111151174  inhibitor of nuclear factor kappa-B kinase subunit epsilon isoform X1 [KO:K07211] [EC:2.7.11.10]
111142106  serine/threonine-protein kinase TBK1 isoform X1 [KO:K05410] [EC:2.7.11.10]
111150049  interferon regulatory factor 7 [KO:K09447]
111140482  interferon alpha-1/2-like [KO:K05414]
111159856  interferon alpha-1/2-like [KO:K05414]
111159858  interferon alpha-1/2-like [KO:K05414]
111159859  interferon alpha-1/2-like [KO:K05414]
111159861  interferon alpha-1/2-like [KO:K05414]
111159862  interferon alpha-1/2-like [KO:K05414]
111156578  interferon alpha-2-like [KO:K05414]
111156593  interferon alpha-1/2-like [KO:K05414]
111156594  interferon alpha-1/2-like [KO:K05414]
111156604  interferon alpha-like [KO:K05414]
111140592  interferon alpha-1/2-like [KO:K05414]
111156606  interferon alpha-1/2-like [KO:K05414]
111156609  interferon alpha-1/2-like [KO:K05414]
111140329  interferon alpha-1/2-like [KO:K05414]
111140335  interferon alpha-1/2-like [KO:K05414]
111140336  interferon alpha-1/2-like [KO:K05414]
111160645  interferon regulatory factor 3 isoform X1 [KO:K05411]
111157665  histone acetyltransferase p300 [KO:K04498] [EC:2.3.1.48]
111156131  LOW QUALITY PROTEIN: CREB-binding protein [KO:K04498] [EC:2.3.1.48]
111156577  interferon beta [KO:K05415]
111155707  interferon alpha/beta receptor 1 [KO:K05130]
111155645  interferon alpha/beta receptor 2 isoform X1 [KO:K05131]
111142881  tyrosine-protein kinase JAK1 [KO:K11217] [EC:2.7.10.2]
111162402  non-receptor tyrosine-protein kinase TYK2 isoform X1 [KO:K11219] [EC:2.7.10.2]
111144592  signal transducer and activator of transcription 1-alpha/beta isoform X1 [KO:K11220]
111160141  signal transducer and activator of transcription 2 isoform X1 [KO:K11221]
111140721  interferon regulatory factor 9 isoform X1 [KO:K04693]
111158436  interferon-induced, double-stranded RNA-activated protein kinase [KO:K16195] [EC:2.7.11.1]
111152267  mitogen-activated protein kinase 13 [KO:K04441] [EC:2.7.11.24]
111157625  mitogen-activated protein kinase 11 isoform X1 [KO:K04441] [EC:2.7.11.24]
111157628  mitogen-activated protein kinase 12 isoform X1 [KO:K04441] [EC:2.7.11.24]
111152183  mitogen-activated protein kinase 14 isoform X1 [KO:K04441] [EC:2.7.11.24]
111151153  MAP kinase-activated protein kinase 2 [KO:K04443] [EC:2.7.11.1]
111158041  dual specificity mitogen-activated protein kinase kinase 6 isoform X1 [KO:K04433] [EC:2.7.12.2]
111161492  mRNA decay activator protein ZFP36 [KO:K15308]
111147365  interleukin-6 isoform X1 [KO:K05405]
111141239  granulocyte-macrophage colony-stimulating factor [KO:K05427]
111144227  C-C chemokine receptor type 3 [KO:K04178]
111143981  C-C chemokine receptor type 5 [KO:K04180]
111143875  C-C chemokine receptor type 1-like [KO:K04176]
111159151  C-C chemokine receptor type 4 [KO:K04179]
111159160  C-C chemokine receptor type 8 [KO:K04183]
111144883  tumor necrosis factor receptor superfamily member 6 [KO:K04390]
111149616  FAS-associated death domain protein [KO:K02373]
111141026  caspase-8 isoform X1 [KO:K04398] [EC:3.4.22.61]
111159768  BH3-interacting domain death agonist [KO:K04726]
111160657  apoptosis regulator BAX isoform X1 [KO:K02159]
111152355  bcl-2 homologous antagonist/killer [KO:K14021]
111147305  cytochrome c isoform X1 [KO:K08738]
111142635  LOW QUALITY PROTEIN: cytochrome c, testis-specific-like [KO:K08738]
111141900  LOW QUALITY PROTEIN: uncharacterized protein LOC111141900 [KO:K08738]
111154673  caspase-9 isoform X1 [KO:K04399] [EC:3.4.22.62]
111144607  caspase-3 [KO:K02187] [EC:3.4.22.56]
111159748  tumor necrosis factor receptor superfamily member 1A [KO:K03158]
111152832  tumor necrosis factor receptor type 1-associated DEATH domain protein [KO:K03171]
111145476  TNF receptor-associated factor 2-like [KO:K03173] [EC:2.3.2.27]
111146100  TNF receptor-associated factor 2 isoform X1 [KO:K03173] [EC:2.3.2.27]
111144921  inhibitor of nuclear factor kappa-B kinase subunit alpha isoform X1 [KO:K04467] [EC:2.7.11.10]
111144397  inhibitor of nuclear factor kappa-B kinase subunit beta isoform X1 [KO:K07209] [EC:2.7.11.10]
111139191  NF-kappa-B essential modulator [KO:K07210]
111140276  NF-kappa-B inhibitor alpha isoform X1 [KO:K04734]
111153611  nuclear factor NF-kappa-B p105 subunit isoform X1 [KO:K02580]
111149956  transcription factor p65 [KO:K04735]
111161133  cellular tumor antigen p53 [KO:K04451]
111147618  cyclin-dependent kinase inhibitor 1 [KO:K06625]
111160230  cyclin-dependent kinase 4 [KO:K02089] [EC:2.7.11.22]
111147246  cyclin-dependent kinase 6 [KO:K02091] [EC:2.7.11.22]
111146911  retinoblastoma-associated protein [KO:K06618]
111141556  transcription factor E2F1 [KO:K17454]
111154729  transcription factor E2F2 isoform X1 [KO:K09389]
111138625  transcription factor E2F3 isoform X1 [KO:K06620]
111152501  HLA class I histocompatibility antigen, alpha chain G-like isoform X1 [KO:K06751]
111139664  LOW QUALITY PROTEIN: H-2 class I histocompatibility antigen, Q8 alpha chain-like [KO:K06751]
111152201  LOW QUALITY PROTEIN: DLA class I histocompatibility antigen, A9/A9 alpha chain-like [KO:K06751]
111152203  DLA class I histocompatibility antigen, A9/A9 alpha chain-like [KO:K06751]
111152204  DLA class I histocompatibility antigen, A9/A9 alpha chain-like isoform X1 [KO:K06751]
111152405  LOW QUALITY PROTEIN: HLA class I histocompatibility antigen, A-36 alpha chain [KO:K06751]
111147686  interferon gamma receptor 1 [KO:K05132]
111162530  intercellular adhesion molecule 1 [KO:K06490]
111155017  T-lymphocyte activation antigen CD86 isoform X1 [KO:K05413]
111142117  C-type lectin domain family 2 member B [KO:K10071]
111154816  ubiquitin-60S ribosomal protein L40-like [KO:K02927]
111148280  ubiquitin-like isoform X1 [KO:K02927]
111143805  ubiquitin-60S ribosomal protein L40 isoform X1 [KO:K02927]
111141316  ubiquitin-60S ribosomal protein L40-like isoform X1 [KO:K02927]
111148109  ubiquitin-40S ribosomal protein S27a [KO:K02977]
111139471  LOW QUALITY PROTEIN: polyubiquitin-B [KO:K04551]
111150658  beclin-2 [KO:K08334]
111151520  beclin-1 isoform X1 [KO:K08334]
111162436  beclin 1-associated autophagy-related key regulator [KO:K17889]
111142649  phosphatidylinositol 3-kinase catalytic subunit type 3 isoform X1 [KO:K00914] [EC:2.7.1.137]
111147729  ubiquitin-like-conjugating enzyme ATG3 isoform X1 [KO:K08343]
111150637  microtubule-associated proteins 1A/1B light chain 3C [KO:K10435]
111152982  microtubule-associated proteins 1A/1B light chain 3B [KO:K10435]
111141551  microtubule-associated proteins 1A/1B light chain 3A [KO:K10435]
111154601  guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1 [KO:K04536]
111145586  guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-2 isoform X1 [KO:K04537]
111159773  guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-3 [KO:K07825]
111148588  guanine nucleotide-binding protein subunit beta-4 [KO:K04538]
111140421  guanine nucleotide-binding protein subunit beta-5 [KO:K04539]
111159618  guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2 isoform X1 [KO:K07826]
111149566  guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-3 [KO:K04540]
111160502  guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-4 [KO:K04541]
111143000  guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-5 [KO:K04542]
111161718  guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-7 [KO:K04543]
111160835  guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-8 [KO:K04544]
111145828  guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-10 [KO:K04545]
111147333  guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-11 [KO:K04546]
111162432  uncharacterized LOC105372280 homolog [KO:K04347]
111142967  guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-12 [KO:K04347]
111156207  guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-13 [KO:K04547]
111147281  guanine nucleotide-binding protein G(T) subunit gamma-T1 [KO:K04548]
111151818  guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-T2 [KO:K04549]
111140316  GTPase HRas isoform X1 [KO:K02833]
111159984  GTPase KRas isoform X1 [KO:K07827]
111143238  GTPase NRas [KO:K07828]
111144322  RAF proto-oncogene serine/threonine-protein kinase isoform X1 [KO:K04366] [EC:2.7.11.1]
111153158  dual specificity mitogen-activated protein kinase kinase 1 [KO:K04368] [EC:2.7.12.2]
111161815  dual specificity mitogen-activated protein kinase kinase 2 [KO:K04369] [EC:2.7.12.2]
111162236  LOW QUALITY PROTEIN: mitogen-activated protein kinase 3 [KO:K04371] [EC:2.7.11.24]
111142759  mitogen-activated protein kinase 1 [KO:K04371] [EC:2.7.11.24]
111159390  hypoxia-inducible factor 1-alpha isoform X1 [KO:K08268]
111143174  transcription factor AP-1 [KO:K04448]
111148602  proto-oncogene c-Fos [KO:K04379]
111155215  phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform [KO:K21289] [EC:2.7.1.153]
111161090  phosphoinositide 3-kinase regulatory subunit 6 [KO:K21290]
111161150  phosphoinositide 3-kinase regulatory subunit 5 [KO:K21290]
111155003  LOW QUALITY PROTEIN: phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform [KO:K00922] [EC:2.7.1.153]
111147545  phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform [KO:K00922] [EC:2.7.1.153]
111154641  phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform isoform X1 [KO:K00922] [EC:2.7.1.153]
111143470  phosphatidylinositol 3-kinase regulatory subunit gamma isoform X1 [KO:K02649]
111155224  phosphatidylinositol 3-kinase regulatory subunit alpha isoform X1 [KO:K02649]
111143790  phosphatidylinositol 3-kinase regulatory subunit beta [KO:K02649]
111161374  RAC-beta serine/threonine-protein kinase [KO:K04456] [EC:2.7.11.1]
111148765  RAC-alpha serine/threonine-protein kinase isoform X1 [KO:K04456] [EC:2.7.11.1]
111150885  RAC-gamma serine/threonine-protein kinase isoform X1 [KO:K04456] [EC:2.7.11.1]
111154883  serine/threonine-protein kinase mTOR [KO:K07203] [EC:2.7.11.1]
111141372  phosphatidylinositol 3,4,5-trisphosphate-dependent Rac exchanger 1 protein isoform X1 [KO:K12365]
111145636  ras-related C3 botulinum toxin substrate 1 isoform X1 [KO:K04392]
111144860  mitogen-activated protein kinase 8 [KO:K04440] [EC:2.7.11.24]
111158897  mitogen-activated protein kinase 9 isoform X1 [KO:K04440] [EC:2.7.11.24]
111154016  mitogen-activated protein kinase 10 isoform X1 [KO:K04440] [EC:2.7.11.24]
111151522  cell surface glycoprotein CD200 receptor 1-like [KO:K21668]
111146350  cell surface glycoprotein CD200 receptor 2-like [KO:K21668]
111150514  cell surface glycoprotein CD200 receptor 1-like [KO:K21668]
111153538  tyrosine-protein kinase SYK isoform X1 [KO:K05855] [EC:2.7.10.2]
111141563  proto-oncogene tyrosine-protein kinase Src [KO:K05704] [EC:2.7.10.2]
111141509  tyrosine-protein kinase HCK isoform X1 [KO:K08893] [EC:2.7.10.2]
111155370  tyrosine-protein kinase Lyn isoform X1 [KO:K05854] [EC:2.7.10.2]
111161210  dual specificity mitogen-activated protein kinase kinase 4 isoform X1 [KO:K04430] [EC:2.7.12.2]
111161723  dual specificity mitogen-activated protein kinase kinase 7 isoform X1 [KO:K04431] [EC:2.7.12.2]
111152978  1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-2 isoform X1 [KO:K05859] [EC:3.1.4.11]
111141423  1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1 isoform X1 [KO:K01116] [EC:3.1.4.11]
111144005  inositol 1,4,5-trisphosphate receptor type 1 isoform X1 [KO:K04958]
111159979  inositol 1,4,5-trisphosphate receptor type 2 isoform X1 [KO:K04959]
111152507  inositol 1,4,5-trisphosphate receptor type 3 [KO:K04960]
111158594  calmodulin-like [KO:K02183]
111158606  calmodulin-like protein 3 [KO:K02183]
111154855  calmodulin-like protein 6 [KO:K02183]
111160633  calmodulin-3 [KO:K02183]
111155835  calmodulin-2 [KO:K02183]
111148494  calmodulin-1 isoform X1 [KO:K02183]
111153268  calmodulin-like protein 4 isoform X1 [KO:K02183]
111144797  serine/threonine-protein phosphatase 2B catalytic subunit beta isoform isoform X1 [KO:K04348] [EC:3.1.3.16]
111154144  serine/threonine-protein phosphatase 2B catalytic subunit gamma isoform isoform X1 [KO:K04348] [EC:3.1.3.16]
111154566  serine/threonine-protein phosphatase 2B catalytic subunit alpha isoform isoform X1 [KO:K04348] [EC:3.1.3.16]
111148007  calcineurin subunit B type 1 [KO:K06268]
111146053  calcineurin subunit B type 2 [KO:K06268]
111154209  nuclear factor of activated T-cells, cytoplasmic 1 isoform X1 [KO:K04446]
111141582  LOW QUALITY PROTEIN: nuclear factor of activated T-cells, cytoplasmic 2 [KO:K17332]
111152752  nuclear factor of activated T-cells, cytoplasmic 3 isoform X1 [KO:K17333]
111160328  nuclear factor of activated T-cells, cytoplasmic 4 isoform X1 [KO:K17334]
111149115  interleukin-8 [KO:K10030]
111150791  prostaglandin G/H synthase 2 [KO:K11987] [EC:1.14.99.1]
111148819  growth-regulated protein homolog gamma-like [KO:K05505]
111149266  LOW QUALITY PROTEIN: growth-regulated alpha protein-like [KO:K05505]
111155692  calcipressin-1 isoform X1 [KO:K17901]
111156005  LOW QUALITY PROTEIN: fibroblast growth factor 2 [KO:K18497]
111147726  vascular endothelial growth factor A [KO:K05448]
111157534  platelet-derived growth factor subunit B isoform X1 [KO:K17386]
111144573  angiopoietin-2 isoform X1 [KO:K05466]
111156948  interleukin-6 receptor subunit beta [KO:K05060]
111153517  tyrosine-protein kinase JAK2 [KO:K04447] [EC:2.7.10.2]
111151241  signal transducer and activator of transcription 3 isoform X1 [KO:K04692]
111149921  glycogen synthase kinase-3 beta isoform X1 [KO:K03083] [EC:2.7.11.26]
111159001  catenin beta-1 [KO:K02105]
111141244  transcription factor 7 isoform X1 [KO:K02620]
111148131  transcription factor 7-like 1 isoform X1 [KO:K04490]
111145217  transcription factor 7-like 2 isoform X1 [KO:K04491]
111154120  lymphoid enhancer-binding factor 1 isoform X1 [KO:K04492]
111147575  cyclic AMP-responsive element-binding protein 1 isoform X1 [KO:K05870]
111149458  G1/S-specific cyclin-D1 [KO:K04503]
111146783  myc proto-oncogene protein [KO:K04377]
Compound
C00076  Calcium cation
C00165  Diacylglycerol
C00350  Phosphatidylethanolamine
C01245  D-myo-Inositol 1,4,5-trisphosphate
C05981  Phosphatidylinositol-3,4,5-trisphosphate
Reference
PMID:22403573
  Authors
Lee HR, Brulois K, Wong L, Jung JU
  Title
Modulation of Immune System by Kaposi's Sarcoma-Associated Herpesvirus: Lessons from Viral Evasion Strategies.
  Journal
Front Microbiol 3:44 (2012)
DOI:10.3389/fmicb.2012.00044
Reference
PMID:18948197
  Authors
Liang C, Lee JS, Jung JU
  Title
Immune evasion in Kaposi's sarcoma-associated herpes virus associated oncogenesis.
  Journal
Semin Cancer Biol 18:423-36 (2008)
DOI:10.1016/j.semcancer.2008.09.003
Reference
PMID:21040832
  Authors
Cai Q, Verma SC, Lu J, Robertson ES
  Title
Molecular biology of Kaposi's sarcoma-associated herpesvirus and related oncogenesis.
  Journal
Adv Virus Res 78:87-142 (2010)
DOI:10.1016/B978-0-12-385032-4.00003-3
Reference
PMID:16760382
  Authors
Rezaee SA, Cunningham C, Davison AJ, Blackbourn DJ
  Title
Kaposi's sarcoma-associated herpesvirus immune modulation: an overview.
  Journal
J Gen Virol 87:1781-804 (2006)
DOI:10.1099/vir.0.81919-0
Reference
PMID:19230674
  Authors
Areste C, Blackbourn DJ
  Title
Modulation of the immune system by Kaposi's sarcoma-associated herpesvirus.
  Journal
Trends Microbiol 17:119-29 (2009)
DOI:10.1016/j.tim.2008.12.001
Reference
PMID:16905191
  Authors
Mark L, Spiller OB, Villoutreix BO, Blom AM
  Title
Kaposi's sarcoma-associated herpes virus complement control protein: KCP--complement inhibition and more.
  Journal
Mol Immunol 44:11-22 (2007)
DOI:10.1016/j.molimm.2006.06.018
Reference
PMID:11500830
  Authors
Weber KS, Grone HJ, Rocken M, Klier C, Gu S, Wank R, Proudfoot AE, Nelson PJ, Weber C
  Title
Selective recruitment of Th2-type cells and evasion from a cytotoxic immune response mediated by viral macrophage inhibitory protein-II.
  Journal
Eur J Immunol 31:2458-66 (2001)
DOI:10.1002/1521-4141(200108)31:8<2458::AID-IMMU2458>3.0.CO;2-L
Reference
PMID:10666184
  Authors
Stine JT, Wood C, Hill M, Epp A, Raport CJ, Schweickart VL, Endo Y, Sasaki T, Simmons G, Boshoff C, Clapham P, Chang Y, Moore P, Gray PW, Chantry D
  Title
KSHV-encoded CC chemokine vMIP-III is a CCR4 agonist, stimulates angiogenesis, and selectively chemoattracts TH2 cells.
  Journal
Blood 95:1151-7 (2000)
Reference
PMID:26431609
  Authors
Schulz TF, Cesarman E
  Title
Kaposi Sarcoma-associated Herpesvirus: mechanisms of oncogenesis.
  Journal
Curr Opin Virol 14:116-28 (2015)
DOI:10.1016/j.coviro.2015.08.016
Reference
PMID:10377196
  Authors
Endres MJ, Garlisi CG, Xiao H, Shan L, Hedrick JA
  Title
The Kaposi's sarcoma-related herpesvirus (KSHV)-encoded chemokine vMIP-I is a specific agonist for the CC chemokine receptor (CCR)8.
  Journal
J Exp Med 189:1993-8 (1999)
DOI:10.1084/jem.189.12.1993
Reference
PMID:18434408
  Authors
Choi YB, Nicholas J
  Title
Autocrine and paracrine promotion of cell survival and virus replication by human herpesvirus 8 chemokines.
  Journal
J Virol 82:6501-13 (2008)
DOI:10.1128/JVI.02396-07
Reference
PMID:15692053
  Authors
McCormick C, Ganem D
  Title
The kaposin B protein of KSHV activates the p38/MK2 pathway and stabilizes cytokine mRNAs.
  Journal
Science 307:739-41 (2005)
DOI:10.1126/science.1105779
Reference
PMID:15967719
  Authors
Wang HW, Boshoff C
  Title
Linking Kaposi virus to cancer-associated cytokines.
  Journal
Trends Mol Med 11:309-12 (2005)
DOI:10.1016/j.molmed.2005.06.002
Reference
PMID:16828973
  Authors
Jarviluoma A, Ojala PM
  Title
Cell signaling pathways engaged by KSHV.
  Journal
Biochim Biophys Acta 1766:140-58 (2006)
DOI:10.1016/j.bbcan.2006.05.001
Reference
PMID:12032073
  Authors
Wang HW, Sharp TV, Koumi A, Koentges G, Boshoff C
  Title
Characterization of an anti-apoptotic glycoprotein encoded by Kaposi's sarcoma-associated herpesvirus which resembles a spliced variant of human survivin.
  Journal
EMBO J 21:2602-15 (2002)
DOI:10.1093/emboj/21.11.2602
Reference
PMID:10510092
  Authors
Djerbi M, Screpanti V, Catrina AI, Bogen B, Biberfeld P, Grandien A
  Title
The inhibitor of death receptor signaling, FLICE-inhibitory protein defines a new class of tumor progression factors.
  Journal
J Exp Med 190:1025-32 (1999)
DOI:10.1084/jem.190.7.1025
Reference
PMID:10523854
  Authors
Chaudhary PM, Jasmin A, Eby MT, Hood L
  Title
Modulation of the NF-kappa B pathway by virally encoded death effector domains-containing proteins.
  Journal
Oncogene 18:5738-46 (1999)
DOI:10.1038/sj.onc.1202976
Reference
PMID:12890756
  Authors
Field N, Low W, Daniels M, Howell S, Daviet L, Boshoff C, Collins M
  Title
KSHV vFLIP binds to IKK-gamma to activate IKK.
  Journal
J Cell Sci 116:3721-8 (2003)
DOI:10.1242/jcs.00691
Reference
PMID:20865011
  Authors
Mesri EA, Cesarman E, Boshoff C
  Title
Kaposi's sarcoma and its associated herpesvirus.
  Journal
Nat Rev Cancer 10:707-19 (2010)
DOI:10.1038/nrc2888
Reference
PMID:10799607
  Authors
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Down-regulation of NKG2D and NKp80 ligands by Kaposi's sarcoma-associated herpesvirus K5 protects against NK cell cytotoxicity.
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Manipulation of glycogen-synthase kinase-3 activity in KSHV-associated cancers.
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Related
pathway
elk04010  MAPK signaling pathway
elk04064  NF-kappa B signaling pathway
elk04110  Cell cycle
elk04115  p53 signaling pathway
elk04140  Autophagy - animal
elk04144  Endocytosis
elk04151  PI3K-Akt signaling pathway
elk04210  Apoptosis
elk04310  Wnt signaling pathway
elk04610  Complement and coagulation cascades
elk04620  Toll-like receptor signaling pathway
elk04630  JAK-STAT signaling pathway
elk04650  Natural killer cell mediated cytotoxicity
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KO pathway
ko05167   
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