KEGG   PATHWAY: etf04151
Entry
etf04151                    Pathway                                
Name
PI3K-Akt signaling pathway - Echinops telfairi (small Madagascar hedgehog)
Description
The phosphatidylinositol 3' -kinase(PI3K)-Akt signaling pathway is activated by many types of cellular stimuli or toxic insults and regulates fundamental cellular functions such as transcription, translation, proliferation, growth, and survival. The binding of growth factors to their receptor tyrosine kinase (RTK) or G protein-coupled receptors (GPCR) stimulates class Ia and Ib PI3K isoforms, respectively. PI3K catalyzes the production of phosphatidylinositol-3,4,5-triphosphate (PIP3) at the cell membrane. PIP3 in turn serves as a second messenger that helps to activate Akt. Once active, Akt can control key cellular processes by phosphorylating substrates involved in apoptosis, protein synthesis, metabolism, and cell cycle.
Class
Environmental Information Processing; Signal transduction
Pathway map
etf04151  PI3K-Akt signaling pathway
etf04151

Other DBs
GO: 0043491
Organism
Echinops telfairi (small Madagascar hedgehog) [GN:etf]
Gene
101645300  EGF; pro-epidermal growth factor [KO:K04357]
101659761  TGFA; protransforming growth factor alpha [KO:K08774]
101648960  EREG; proepiregulin [KO:K09784]
101649279  AREG; amphiregulin [KO:K09782]
101654974  FGF1; fibroblast growth factor 1 [KO:K18496]
101640090  FGF2; fibroblast growth factor 2 [KO:K18497]
101657384  FGF6; fibroblast growth factor 6 [KO:K04358]
101655892  FGF7; fibroblast growth factor 7 [KO:K04358]
101645725  FGF5; fibroblast growth factor 5 isoform X1 [KO:K04358]
101658407  FGF3; fibroblast growth factor 3 [KO:K04358]
101654224  FGF20; fibroblast growth factor 20 [KO:K04358]
101659774  FGF18; fibroblast growth factor 18 [KO:K04358]
101641057  FGF9; fibroblast growth factor 9 [KO:K04358]
101645168  FGF16; fibroblast growth factor 16 [KO:K04358]
101649614  FGF17; fibroblast growth factor 17 isoform X1 [KO:K04358]
101656763  FGF22; fibroblast growth factor 22 [KO:K04358]
101644233  FGF8; fibroblast growth factor 8 [KO:K04358]
101657770  FGF19; fibroblast growth factor 19 [KO:K22603]
101645758  FGF21; fibroblast growth factor 21 [KO:K22429]
101659280  FGF23; fibroblast growth factor 23 [KO:K22428]
101658298  NGF; beta-nerve growth factor [KO:K02582]
101643198  BDNF; brain-derived neurotrophic factor isoform X1 [KO:K04355]
101649580  NTF3; neurotrophin-3 isoform X1 [KO:K04356]
101647770  NTF4; neurotrophin-4 [KO:K12457]
101641705  INS; insulin [KO:K04526]
101644114  IGF1; insulin-like growth factor I isoform X2 [KO:K05459]
101657076  IGF2; insulin-like growth factor II [KO:K13769]
101657212  PDGFA; platelet-derived growth factor subunit A [KO:K04359]
101642424  PDGFB; platelet-derived growth factor subunit B [KO:K17386]
101647643  PDGFC; platelet-derived growth factor C [KO:K05450]
101654830  PDGFD; platelet-derived growth factor D isoform X1 [KO:K05450]
101657479  CSF1; LOW QUALITY PROTEIN: macrophage colony-stimulating factor 1 [KO:K05453]
101644116  KITLG; kit ligand isoform X1 [KO:K05461]
101655782  FLT3LG; fms-related tyrosine kinase 3 ligand [KO:K05454]
101655464  VEGFA; vascular endothelial growth factor A [KO:K05448]
101650383  VEGFB; vascular endothelial growth factor B [KO:K16858]
101654245  PGF; placenta growth factor [KO:K16859]
101664676  VEGFD; vascular endothelial growth factor D isoform X1 [KO:K05449]
101649959  VEGFC; vascular endothelial growth factor C [KO:K05449]
101659919  HGF; hepatocyte growth factor isoform X1 [KO:K05460]
101640418  ANGPT1; angiopoietin-1 isoform X1 [KO:K05465]
101645535  ANGPT2; angiopoietin-2 isoform X1 [KO:K05466]
101648310  ANGPT4; angiopoietin-4 [KO:K05467]
101641001  EFNA5; ephrin-A5 [KO:K05462]
123520870  EFNA4; ephrin-A4 [KO:K05462]
101660733  EFNA1; ephrin-A1 [KO:K05462]
101660415  EFNA3; ephrin-A3 [KO:K05462]
101644402  GDNF; glial cell line-derived neurotrophic factor isoform X1 [KO:K05452]
101638529  NRTN; neurturin [KO:K25414]
101642723  PSPN; persephin [KO:K25416]
101652848  EGFR; epidermal growth factor receptor [KO:K04361] [EC:2.7.10.1]
101647544  ERBB2; receptor tyrosine-protein kinase erbB-2 [KO:K05083] [EC:2.7.10.1]
101663176  ERBB3; LOW QUALITY PROTEIN: receptor tyrosine-protein kinase erbB-3 [KO:K05084] [EC:2.7.10.1]
101652176  ERBB4; receptor tyrosine-protein kinase erbB-4 isoform X1 [KO:K05085] [EC:2.7.10.1]
101650479  FGFR1; fibroblast growth factor receptor 1 isoform X1 [KO:K04362] [EC:2.7.10.1]
101658234  FGFR2; fibroblast growth factor receptor 2 isoform X4 [KO:K05093] [EC:2.7.10.1]
101644525  FGFR3; LOW QUALITY PROTEIN: fibroblast growth factor receptor 3 [KO:K05094] [EC:2.7.10.1]
101644075  FGFR4; fibroblast growth factor receptor 4 isoform X1 [KO:K05095] [EC:2.7.10.1]
101662350  NGFR; tumor necrosis factor receptor superfamily member 16 [KO:K02583]
101647167  NTRK1; high affinity nerve growth factor receptor [KO:K03176] [EC:2.7.10.1]
101654367  NTRK2; BDNF/NT-3 growth factors receptor isoform X1 [KO:K04360] [EC:2.7.10.1]
101657077  INSR; insulin receptor [KO:K04527] [EC:2.7.10.1]
101643319  IGF1R; insulin-like growth factor 1 receptor [KO:K05087] [EC:2.7.10.1]
101663213  PDGFRA; platelet-derived growth factor receptor alpha [KO:K04363] [EC:2.7.10.1]
101650381  PDGFRB; platelet-derived growth factor receptor beta isoform X1 [KO:K05089] [EC:2.7.10.1]
101650070  CSF1R; macrophage colony-stimulating factor 1 receptor [KO:K05090] [EC:2.7.10.1]
101663524  KIT; mast/stem cell growth factor receptor Kit [KO:K05091] [EC:2.7.10.1]
101654556  FLT3; receptor-type tyrosine-protein kinase FLT3 [KO:K05092] [EC:2.7.10.1]
101653928  FLT1; vascular endothelial growth factor receptor 1 [KO:K05096] [EC:2.7.10.1]
101648303  FLT4; vascular endothelial growth factor receptor 3 [KO:K05097] [EC:2.7.10.1]
101643189  KDR; vascular endothelial growth factor receptor 2 isoform X1 [KO:K05098] [EC:2.7.10.1]
101651069  MET; hepatocyte growth factor receptor [KO:K05099] [EC:2.7.10.1]
101658503  TEK; angiopoietin-1 receptor [KO:K05121] [EC:2.7.10.1]
101657615  EPHA2; ephrin type-A receptor 2 [KO:K05103] [EC:2.7.10.1]
101651034  RET; proto-oncogene tyrosine-protein kinase receptor Ret [KO:K05126] [EC:2.7.10.1]
101660259  GRB2; growth factor receptor-bound protein 2 isoform X1 [KO:K04364]
101649001  SOS1; son of sevenless homolog 1 isoform X1 [KO:K03099]
101646109  SOS2; son of sevenless homolog 2 [KO:K03099]
101663997  HRAS; GTPase HRas isoform X1 [KO:K02833]
101639926  KRAS; GTPase KRas isoform X3 [KO:K07827]
101649328  GTPase NRas-like [KO:K07828]
101653520  NRAS; GTPase NRas [KO:K07828]
101656360  RAF1; RAF proto-oncogene serine/threonine-protein kinase isoform X3 [KO:K04366] [EC:2.7.11.1]
101650474  MAP2K1; dual specificity mitogen-activated protein kinase kinase 1 [KO:K04368] [EC:2.7.12.2]
101643986  MAP2K2; dual specificity mitogen-activated protein kinase kinase 2 [KO:K04369] [EC:2.7.12.2]
101648971  MAPK3; mitogen-activated protein kinase 3 [KO:K04371] [EC:2.7.11.24]
101661786  MAPK1; mitogen-activated protein kinase 1 [KO:K04371] [EC:2.7.11.24]
101650216  IRS1; insulin receptor substrate 1 [KO:K16172]
101643417  TLR2; toll-like receptor 2 isoform X1 [KO:K10159]
101660600  TLR4; toll-like receptor 4 [KO:K10160]
101644576  RAC1; ras-related C3 botulinum toxin substrate 1 [KO:K04392]
101654763  SYK; tyrosine-protein kinase SYK [KO:K05855] [EC:2.7.10.2]
101645949  CD19; B-lymphocyte antigen CD19 isoform X1 [KO:K06465]
101650211  PIK3AP1; phosphoinositide 3-kinase adapter protein 1 [KO:K12230]
101659532  somatotropin [KO:K05438]
101657861  PRL; prolactin [KO:K05439]
101638351  OSM; oncostatin-M [KO:K05418]
101658181  IL2; interleukin-2 [KO:K05429]
123522712  interleukin-6-like [KO:K05405]
101644240  IL6; interleukin-6 [KO:K05405]
101653709  IL4; interleukin-4 [KO:K05430]
101642813  IL7; interleukin-7 [KO:K05431]
101650862  interferon alpha-2-like [KO:K05414]
101650550  IFNB1; interferon beta [KO:K05415]
101663716  EPO; erythropoietin [KO:K05437]
101649734  CSF3; granulocyte colony-stimulating factor [KO:K05423]
101657488  GHR; growth hormone receptor [KO:K05080]
101647370  PRLR; prolactin receptor [KO:K05081]
101658420  OSMR; oncostatin-M-specific receptor subunit beta isoform X1 [KO:K05057]
101638943  IL2RA; interleukin-2 receptor subunit alpha [KO:K05068]
101664105  IL2RB; interleukin-2 receptor subunit beta [KO:K05069]
101657280  IL2RG; LOW QUALITY PROTEIN: cytokine receptor common subunit gamma [KO:K05070]
101661680  IL6R; interleukin-6 receptor subunit alpha [KO:K05055]
101647853  IL4R; interleukin-4 receptor subunit alpha isoform X1 [KO:K05071]
101647050  IL7R; interleukin-7 receptor subunit alpha [KO:K05072]
101640204  IFNAR1; interferon alpha/beta receptor 1 [KO:K05130]
101639566  IFNAR2; interferon alpha/beta receptor 2 isoform X1 [KO:K05131]
101659086  EPOR; erythropoietin receptor [KO:K05079]
101655661  CSF3R; granulocyte colony-stimulating factor receptor [KO:K05061]
101664197  JAK1; tyrosine-protein kinase JAK1 isoform X1 [KO:K11217] [EC:2.7.10.2]
101659376  JAK2; tyrosine-protein kinase JAK2 isoform X1 [KO:K04447] [EC:2.7.10.2]
101641163  JAK3; tyrosine-protein kinase JAK3 [KO:K11218] [EC:2.7.10.2]
101647520  COL1A2; collagen alpha-2(I) chain [KO:K06236]
101647433  COL1A1; collagen alpha-1(I) chain isoform X1 [KO:K06236]
101654123  COL2A1; collagen alpha-1(II) chain [KO:K19719]
101643909  COL4A4; collagen alpha-4(IV) chain [KO:K06237]
101644236  COL4A3; collagen alpha-3(IV) chain [KO:K06237]
101652633  COL4A6; collagen alpha-6(IV) chain isoform X1 [KO:K06237]
101653376  COL4A5; collagen alpha-5(IV) chain isoform X3 [KO:K06237]
101641415  COL4A2; collagen alpha-2(IV) chain [KO:K06237]
101640794  COL4A1; collagen alpha-1(IV) chain [KO:K06237]
101663069  COL6A3; collagen alpha-3(VI) chain [KO:K06238]
101656273  collagen alpha-4(VI) chain-like [KO:K06238]
101655976  COL6A5; collagen alpha-5(VI) chain [KO:K06238]
101640842  COL6A2; collagen alpha-2(VI) chain [KO:K06238]
101655657  collagen alpha-6(VI) chain [KO:K06238]
101661038  COL6A1; collagen alpha-1(VI) chain [KO:K06238]
101649332  COL9A1; collagen alpha-1(IX) chain [KO:K08131]
101638906  COL9A2; collagen alpha-2(IX) chain isoform X1 [KO:K08131]
101661473  COL9A3; collagen alpha-3(IX) chain [KO:K08131]
101656678  LAMA2; laminin subunit alpha-2 isoform X1 [KO:K05637]
101644673  LAMA1; laminin subunit alpha-1 [KO:K05637]
101656584  LAMA3; LOW QUALITY PROTEIN: laminin subunit alpha-3 [KO:K06240]
101646645  LAMA5; laminin subunit alpha-5 [KO:K06240]
101638457  LAMA4; laminin subunit alpha-4 [KO:K06241]
101659204  LAMB1; laminin subunit beta-1 [KO:K05636]
101657059  laminin subunit beta-2-like [KO:K06243]
101661367  LAMB2; laminin subunit beta-2 [KO:K06243]
101651331  LAMB3; laminin subunit beta-3 [KO:K06244]
101650046  LAMC1; laminin subunit gamma-1 [KO:K05635]
101649731  LAMC2; laminin subunit gamma-2 [KO:K06246]
101658928  LAMC3; laminin subunit gamma-3 [KO:K06247]
101645956  CHAD; chondroadherin [KO:K06248]
101651758  RELN; reelin isoform X1 [KO:K06249] [EC:3.4.21.-]
101656527  THBS1; thrombospondin-1 isoform X2 [KO:K16857]
101660448  THBS2; thrombospondin-2 isoform X1 [KO:K04659]
101661187  cartilage oligomeric matrix protein [KO:K04659]
101639732  THBS4; thrombospondin-4 [KO:K04659]
101662616  THBS3; thrombospondin-3 isoform X1 [KO:K04659]
101653760  FN1; fibronectin [KO:K05717]
101650745  SPP1; osteopontin [KO:K06250]
101658038  VTN; vitronectin [KO:K06251]
101646924  TNC; tenascin isoform X1 [KO:K06252]
101645767  TNXB; tenascin-X [KO:K06252]
101664456  TNR; tenascin-R [KO:K06252]
101638287  TNN; tenascin-N [KO:K06252]
101651446  VWF; von Willebrand factor [KO:K03900]
101656585  bone sialoprotein 2 [KO:K06253]
101651763  ITGA1; integrin alpha-1 [KO:K06480]
101651459  ITGA2; integrin alpha-2 [KO:K06481]
101644908  ITGA2B; LOW QUALITY PROTEIN: integrin alpha-IIb [KO:K06476]
101648576  ITGA3; LOW QUALITY PROTEIN: integrin alpha-3 [KO:K06482]
101640152  ITGA4; integrin alpha-4 [KO:K06483]
101640652  ITGA5; integrin alpha-5 [KO:K06484]
101663608  ITGA6; integrin alpha-6 [KO:K06485]
101639933  ITGA7; integrin alpha-7 isoform X2 [KO:K06583]
101659770  ITGA8; integrin alpha-8 [KO:K06584]
101653341  ITGA9; integrin alpha-9 [KO:K06585]
101654263  ITGA10; integrin alpha-10 [KO:K06586]
101653494  ITGA11; integrin alpha-11 [KO:K06587]
101643277  ITGAV; integrin alpha-V [KO:K06487]
101652501  ITGB1; integrin beta-1 isoform X2 [KO:K05719]
101653361  ITGB3; integrin beta-3 [KO:K06493]
101660073  ITGB4; integrin beta-4 [KO:K06525]
101645557  ITGB5; LOW QUALITY PROTEIN: integrin beta-5 [KO:K06588]
101653236  ITGB6; integrin beta-6 isoform X1 [KO:K06589]
101660910  ITGB7; integrin beta-7 [KO:K06590]
101662870  ITGB8; integrin beta-8 [KO:K06591]
101647889  PTK2; focal adhesion kinase 1 isoform X12 [KO:K05725] [EC:2.7.10.2]
101641853  PIK3CA; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform [KO:K00922] [EC:2.7.1.153]
101654217  PIK3CB; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform [KO:K00922] [EC:2.7.1.153]
101640675  PIK3CD; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform [KO:K00922] [EC:2.7.1.153]
101655654  PIK3R1; phosphatidylinositol 3-kinase regulatory subunit alpha isoform X1 [KO:K02649]
101659995  PIK3R2; phosphatidylinositol 3-kinase regulatory subunit beta [KO:K02649]
101657368  phosphatidylinositol 3-kinase regulatory subunit gamma isoform X1 [KO:K02649]
101652507  F2R; proteinase-activated receptor 1 [KO:K03914]
101641566  CHRM1; muscarinic acetylcholine receptor M1 [KO:K04129]
101644587  CHRM2; muscarinic acetylcholine receptor M2 [KO:K04130]
101638933  LPAR1; lysophosphatidic acid receptor 1 [KO:K04289]
101656485  LPAR2; lysophosphatidic acid receptor 2 [KO:K04291]
101648321  LPAR3; lysophosphatidic acid receptor 3 [KO:K04294]
101648748  LPAR4; lysophosphatidic acid receptor 4 [KO:K04275]
101660253  LPAR5; lysophosphatidic acid receptor 5 [KO:K08390]
101645788  LPAR6; lysophosphatidic acid receptor 6 [KO:K04273]
101650965  GNB1; guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1 [KO:K04536]
101648866  GNB2; guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-2 [KO:K04537]
101664254  GNB3; guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-3 [KO:K07825]
101642783  GNB4; guanine nucleotide-binding protein subunit beta-4 [KO:K04538]
101663735  GNB5; guanine nucleotide-binding protein subunit beta-5 [KO:K04539]
115868702  GNG2; guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2 [KO:K07826]
115871448  GNG3; guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-3 [KO:K04540]
101643112  GNG4; guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-4 [KO:K04541]
115871023  guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-5-like [KO:K04542]
115872076  guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-5-like [KO:K04542]
115869664  guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-5-like [KO:K04542]
101661086  guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-5 [KO:K04542]
115869972  guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-5 [KO:K04542]
115873712  guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-5-like [KO:K04542]
101659312  guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-5-like [KO:K04542]
115868780  guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-5-like [KO:K04542]
115869401  guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-5-like [KO:K04542]
115873058  GNG7; guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-7 [KO:K04543]
115870368  GNG8; guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-8 [KO:K04544]
115868657  guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-8-like [KO:K04544]
115871976  GNG10; guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-10 [KO:K04545]
101646564  GNG11; guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-11 [KO:K04546]
115869515  GNG14; putative guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-14 [KO:K04347]
115870155  GNG12; guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-12 [KO:K04347]
115872073  putative guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-14 [KO:K04347]
101653350  GNG13; guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-13 [KO:K04547]
101646247  GNGT1; guanine nucleotide-binding protein G(T) subunit gamma-T1 [KO:K04548]
115872861  GNGT2; guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-T2 [KO:K04549]
101649703  PIK3CG; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform [KO:K21289] [EC:2.7.1.153]
101641665  PIK3R6; phosphoinositide 3-kinase regulatory subunit 6 [KO:K21290]
101638717  PIK3R5; phosphoinositide 3-kinase regulatory subunit 5 [KO:K21290]
101661509  PDPK1; 3-phosphoinositide-dependent protein kinase 1 [KO:K06276] [EC:2.7.11.1]
101642015  STK11; serine/threonine-protein kinase STK11 isoform X1 [KO:K07298] [EC:2.7.11.1]
101642508  PRKAA1; 5'-AMP-activated protein kinase catalytic subunit alpha-1 isoform X2 [KO:K07198] [EC:2.7.11.31]
101659697  PRKAA2; 5'-AMP-activated protein kinase catalytic subunit alpha-2 [KO:K07198] [EC:2.7.11.31]
101638668  DDIT4; DNA damage-inducible transcript 4 protein [KO:K08270]
101654757  TSC1; hamartin isoform X2 [KO:K07206]
101663717  TSC2; tuberin isoform X1 [KO:K07207]
101648247  RHEB; GTP-binding protein Rheb [KO:K07208]
101660153  MLST8; target of rapamycin complex subunit LST8 [KO:K08266]
101664135  MTOR; serine/threonine-protein kinase mTOR isoform X1 [KO:K07203] [EC:2.7.11.1]
101649939  RPTOR; regulatory-associated protein of mTOR [KO:K07204]
101645648  eukaryotic translation initiation factor 4E-binding protein 1-like [KO:K07205]
101651127  EIF4EBP1; eukaryotic translation initiation factor 4E-binding protein 1 [KO:K07205]
101654271  EIF4E2; eukaryotic translation initiation factor 4E type 2 [KO:K03259]
101658728  EIF4E1B; eukaryotic translation initiation factor 4E type 1B isoform X2 [KO:K03259]
101658252  EIF4E; eukaryotic translation initiation factor 4E [KO:K03259]
101647176  eukaryotic translation initiation factor 4E-like [KO:K03259]
101652873  RPS6KB2; ribosomal protein S6 kinase beta-2 [KO:K04688] [EC:2.7.11.1]
101653358  RPS6KB1; ribosomal protein S6 kinase beta-1 isoform X1 [KO:K04688] [EC:2.7.11.1]
101661542  EIF4B; eukaryotic translation initiation factor 4B [KO:K03258]
105979636  40S ribosomal protein S6-like [KO:K02991]
101649610  RPS6; 40S ribosomal protein S6 [KO:K02991]
101638289  PRKCA; protein kinase C alpha type [KO:K02677] [EC:2.7.11.13]
101645165  PKN1; serine/threonine-protein kinase N1 [KO:K06071] [EC:2.7.11.13]
101663373  PKN2; LOW QUALITY PROTEIN: serine/threonine-protein kinase N2 [KO:K23691] [EC:2.7.11.13]
101639788  PKN3; serine/threonine-protein kinase N3 [KO:K23692] [EC:2.7.11.13]
101654490  SGK1; serine/threonine-protein kinase Sgk1 isoform X1 [KO:K13302] [EC:2.7.11.1]
101653196  SGK2; serine/threonine-protein kinase Sgk2 [KO:K13303] [EC:2.7.11.1]
101653188  serine/threonine-protein kinase Sgk3 isoform X1 [KO:K13304] [EC:2.7.11.1]
101643102  AKT2; RAC-beta serine/threonine-protein kinase [KO:K04456] [EC:2.7.11.1]
101649881  AKT1; RAC-alpha serine/threonine-protein kinase [KO:K04456] [EC:2.7.11.1]
101655315  AKT3; RAC-gamma serine/threonine-protein kinase isoform X1 [KO:K04456] [EC:2.7.11.1]
101656580  MAGI1; membrane-associated guanylate kinase, WW and PDZ domain-containing protein 1 isoform X14 [KO:K05631]
101640264  MAGI2; membrane-associated guanylate kinase, WW and PDZ domain-containing protein 2 [KO:K05629]
101651134  THEM4; acyl-coenzyme A thioesterase THEM4 [KO:K16339] [EC:3.1.2.2]
101644319  serine/threonine-protein phosphatase 2A catalytic subunit beta isoform-like [KO:K04382] [EC:3.1.3.16]
101644179  PPP2CB; serine/threonine-protein phosphatase 2A catalytic subunit beta isoform [KO:K04382] [EC:3.1.3.16]
101657344  PPP2CA; serine/threonine-protein phosphatase 2A catalytic subunit alpha isoform [KO:K04382] [EC:3.1.3.16]
101645417  PPP2R1B; serine/threonine-protein phosphatase 2A 65 kDa regulatory subunit A beta isoform [KO:K03456]
101647744  LOW QUALITY PROTEIN: serine/threonine-protein phosphatase 2A 65 kDa regulatory subunit A alpha isoform-like [KO:K03456]
101663474  PPP2R1A; serine/threonine-protein phosphatase 2A 65 kDa regulatory subunit A alpha isoform [KO:K03456]
101662513  PPP2R2C; protein phosphatase 2, regulatory subunit B, gamma [KO:K04354]
101662642  PPP2R2D; serine/threonine-protein phosphatase 2A 55 kDa regulatory subunit B delta isoform [KO:K04354]
101657966  PPP2R2B; serine/threonine-protein phosphatase 2A 55 kDa regulatory subunit B beta isoform isoform X1 [KO:K04354]
101659001  PPP2R2A; serine/threonine-protein phosphatase 2A 55 kDa regulatory subunit B alpha isoform [KO:K04354]
101660860  PPP2R3B; serine/threonine-protein phosphatase 2A regulatory subunit B'' subunit beta [KO:K11583]
101659349  PPP2R3A; serine/threonine-protein phosphatase 2A regulatory subunit B'' subunit alpha isoform X1 [KO:K11583]
101651322  PPP2R3C; serine/threonine-protein phosphatase 2A regulatory subunit B'' subunit gamma isoform X2 [KO:K11583]
101655698  PPP2R5B; serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit beta isoform [KO:K11584]
101642174  PPP2R5D; serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit delta isoform [KO:K11584]
101641890  PPP2R5E; serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit epsilon isoform isoform X1 [KO:K11584]
101639916  PPP2R5C; serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit gamma isoform isoform X1 [KO:K11584]
101657070  PPP2R5A; serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit alpha isoform [KO:K11584]
101649746  HSP90AB1; heat shock protein HSP 90-beta [KO:K04079]
101650153  LOW QUALITY PROTEIN: heat shock protein HSP 90-beta-like [KO:K04079]
101639274  HSP90AA1; heat shock protein HSP 90-alpha [KO:K04079]
101656459  LOW QUALITY PROTEIN: endoplasmin-like [KO:K09487]
101642841  HSP90B1; endoplasmin [KO:K09487]
101650206  CDC37; hsp90 co-chaperone Cdc37 [KO:K09554]
101653725  CRTC2; CREB-regulated transcription coactivator 2 [KO:K16333]
101663400  PHLPP1; PH domain leucine-rich repeat-containing protein phosphatase 1 [KO:K16340] [EC:3.1.3.16]
101650031  PHLPP2; PH domain leucine-rich repeat-containing protein phosphatase 2 [KO:K16340] [EC:3.1.3.16]
101655401  TCL1A; T-cell leukemia/lymphoma protein 1A [KO:K10167]
101645606  MTCP1; protein p13 MTCP-1 [KO:K16837]
101644765  NOS3; nitric oxide synthase, endothelial [KO:K13242] [EC:1.14.13.39]
101639869  BRCA1; breast cancer type 1 susceptibility protein isoform X1 [KO:K10605] [EC:2.3.2.27]
101657537  GSK3B; glycogen synthase kinase-3 beta isoform X1 [KO:K03083] [EC:2.7.11.26]
101651083  GYS1; glycogen [starch] synthase, muscle [KO:K00693] [EC:2.4.1.11]
101650073  GYS2; glycogen [starch] synthase, liver [KO:K00693] [EC:2.4.1.11]
101640119  PCK2; phosphoenolpyruvate carboxykinase [GTP], mitochondrial [KO:K01596] [EC:4.1.1.32]
101652483  PCK1; phosphoenolpyruvate carboxykinase, cytosolic [GTP] [KO:K01596] [EC:4.1.1.32]
101643287  G6PC2; LOW QUALITY PROTEIN: glucose-6-phosphatase 2 [KO:K01084] [EC:3.1.3.9]
101661828  G6PC1; glucose-6-phosphatase catalytic subunit 1 [KO:K01084] [EC:3.1.3.9]
101642368  G6PC3; glucose-6-phosphatase 3 [KO:K01084] [EC:3.1.3.9]
101649029  MYC; myc proto-oncogene protein isoform X3 [KO:K04377]
101657154  CCND1; G1/S-specific cyclin-D1 [KO:K04503]
101660587  CDKN1A; cyclin-dependent kinase inhibitor 1 [KO:K06625]
101641071  CDKN1B; cyclin-dependent kinase inhibitor 1B [KO:K06624]
101642843  CDK2; cyclin-dependent kinase 2 isoform X2 [KO:K02206] [EC:2.7.11.22]
101654378  CDK4; cyclin-dependent kinase 4 [KO:K02089] [EC:2.7.11.22]
101645619  CDK6; cyclin-dependent kinase 6 [KO:K02091] [EC:2.7.11.22]
101657079  CCND2; G1/S-specific cyclin-D2 [KO:K10151]
101639447  CCND3; G1/S-specific cyclin-D3 [KO:K10152]
101651720  CCNE2; G1/S-specific cyclin-E2 [KO:K06626]
101649401  CCNE1; G1/S-specific cyclin-E1 isoform X1 [KO:K06626]
101659823  FOXO3; forkhead box protein O3 [KO:K09408]
101658150  RBL2; retinoblastoma-like protein 2 [KO:K16332]
101663725  BCL2L11; bcl-2-like protein 11 isoform X2 [KO:K16341]
101650912  YWHAB; 14-3-3 protein beta/alpha [KO:K16197]
101641454  YWHAQ; 14-3-3 protein theta [KO:K16197]
101647575  YWHAZ; 14-3-3 protein zeta/delta [KO:K16197]
101652654  14-3-3 protein theta-like [KO:K16197]
101644365  YWHAE; 14-3-3 protein epsilon [KO:K06630]
101655441  YWHAG; 14-3-3 protein gamma [KO:K16198]
101644426  YWHAH; 14-3-3 protein eta [KO:K16198]
101658729  BAD; bcl2-associated agonist of cell death [KO:K02158]
101644838  BCL2L1; bcl-2-like protein 1 isoform X1 [KO:K04570]
101659262  bcl-2-like protein 1 [KO:K04570]
101659722  BCL2; apoptosis regulator Bcl-2 [KO:K02161]
101659735  CASP9; caspase-9 [KO:K04399] [EC:3.4.22.62]
101646557  CREB1; cyclic AMP-responsive element-binding protein 1 isoform X1 [KO:K05870]
101656771  ATF2; cyclic AMP-dependent transcription factor ATF-2 isoform X1 [KO:K04450]
101650311  ATF4; cyclic AMP-dependent transcription factor ATF-4 [KO:K04374]
101653565  CREB3L2; cyclic AMP-responsive element-binding protein 3-like protein 2 [KO:K09048]
101648900  CREB3; cyclic AMP-responsive element-binding protein 3 isoform X1 [KO:K09048]
101654666  CREB3L3; cyclic AMP-responsive element-binding protein 3-like protein 3 isoform X2 [KO:K09048]
101654039  CREB3L4; cyclic AMP-responsive element-binding protein 3-like protein 4 isoform X3 [KO:K09048]
101639977  CREB3L1; cyclic AMP-responsive element-binding protein 3-like protein 1 [KO:K09048]
101648034  CREB5; cyclic AMP-responsive element-binding protein 5 isoform X2 [KO:K09047]
101662802  ATF6B; cyclic AMP-dependent transcription factor ATF-6 beta isoform X2 [KO:K09049]
101654686  MCL1; induced myeloid leukemia cell differentiation protein Mcl-1 [KO:K02539]
101655182  RXRA; retinoic acid receptor RXR-alpha [KO:K08524]
101659859  NR4A1; nuclear receptor subfamily 4 group A member 1 isoform X2 [KO:K04465]
101648136  IKBKG; NF-kappa-B essential modulator isoform X1 [KO:K07210]
101649582  CHUK; inhibitor of nuclear factor kappa-B kinase subunit alpha [KO:K04467] [EC:2.7.11.10]
101657011  IKBKB; inhibitor of nuclear factor kappa-B kinase subunit beta [KO:K07209] [EC:2.7.11.10]
101663870  RELA; transcription factor p65 [KO:K04735]
101662652  NFKB1; nuclear factor NF-kappa-B p105 subunit isoform X1 [KO:K02580]
101647086  MYB; transcriptional activator Myb [KO:K09420]
101658440  MDM2; E3 ubiquitin-protein ligase Mdm2 isoform X1 [KO:K06643] [EC:2.3.2.27]
101647784  LOW QUALITY PROTEIN: cellular tumor antigen p53-like [KO:K04451]
101656530  TP53; cellular tumor antigen p53 [KO:K04451]
Compound
C00020  AMP
C00533  Nitric oxide
C04637  1-Phosphatidyl-D-myo-inositol 4,5-bisphosphate
C05981  Phosphatidylinositol-3,4,5-trisphosphate
Reference
PMID:16847462
  Authors
Engelman JA, Luo J, Cantley LC
  Title
The evolution of phosphatidylinositol 3-kinases as regulators of growth and metabolism.
  Journal
Nat Rev Genet 7:606-19 (2006)
DOI:10.1038/nrg1879
Reference
PMID:15784165
  Authors
Song G, Ouyang G, Bao S
  Title
The activation of Akt/PKB signaling pathway and cell survival.
  Journal
J Cell Mol Med 9:59-71 (2005)
DOI:10.1111/j.1582-4934.2005.tb00337.x
Reference
PMID:21620960
  Authors
Hers I, Vincent EE, Tavare JM
  Title
Akt signalling in health and disease.
  Journal
Cell Signal 23:1515-27 (2011)
DOI:10.1016/j.cellsig.2011.05.004
Reference
PMID:18842113
  Authors
Duronio V
  Title
The life of a cell: apoptosis regulation by the PI3K/PKB pathway.
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Biochem J 415:333-44 (2008)
DOI:10.1042/BJ20081056
Reference
PMID:16248975
  Authors
Kim D, Chung J.
  Title
Akt: versatile mediator of cell survival and beyond.
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J Biochem Mol Biol 35:106-15 (2002)
DOI:10.5483/bmbrep.2002.35.1.106
Reference
PMID:12660731
  Authors
Koyasu S
  Title
The role of PI3K in immune cells.
  Journal
Nat Immunol 4:313-9 (2003)
DOI:10.1038/ni0403-313
Reference
PMID:12669022
  Authors
Okkenhaug K, Vanhaesebroeck B.
  Title
PI3K in lymphocyte development, differentiation and activation.
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Nat Rev Immunol 3:317-30 (2003)
DOI:10.1038/nri1056
Reference
PMID:15209374
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Richardson CJ, Schalm SS, Blenis J
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PI3-kinase and TOR: PIKTORing cell growth.
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Semin Cell Dev Biol 15:147-59 (2004)
DOI:10.1016/j.semcdb.2003.12.023
Reference
PMID:21440011
  Authors
Zhang X, Tang N, Hadden TJ, Rishi AK
  Title
Akt, FoxO and regulation of apoptosis.
  Journal
Biochim Biophys Acta 1813:1978-86 (2011)
DOI:10.1016/j.bbamcr.2011.03.010
Reference
PMID:21779440
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Georgescu MM
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PTEN Tumor Suppressor Network in PI3K-Akt Pathway Control.
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Genes Cancer 1:1170-7 (2010)
DOI:10.1177/1947601911407325
Reference
PMID:12531180
  Authors
West KA, Castillo SS, Dennis PA
  Title
Activation of the PI3K/Akt pathway and chemotherapeutic resistance.
  Journal
Drug Resist Updat 5:234-48 (2002)
DOI:10.1016/S1368-7646(02)00120-6
Reference
PMID:9838078
  Authors
Wymann MP, Pirola L
  Title
Structure and function of phosphoinositide 3-kinases.
  Journal
Biochim Biophys Acta 1436:127-50 (1998)
DOI:10.1016/S0005-2760(98)00139-8
Reference
PMID:12048182
  Authors
Moelling K, Schad K, Bosse M, Zimmermann S, Schweneker M
  Title
Regulation of Raf-Akt Cross-talk.
  Journal
J Biol Chem 277:31099-106 (2002)
DOI:10.1074/jbc.M111974200
Reference
PMID:16187290
  Authors
Kikani CK, Dong LQ, Liu F
  Title
"New"-clear functions of PDK1: beyond a master kinase in the cytosol?
  Journal
J Cell Biochem 96:1157-62 (2005)
DOI:10.1002/jcb.20651
Reference
PMID:11357143
  Authors
Blume-Jensen P, Hunter T
  Title
Oncogenic kinase signalling.
  Journal
Nature 411:355-65 (2001)
DOI:10.1038/35077225
Reference
PMID:15505410
  Authors
Osaki M, Oshimura M, Ito H
  Title
PI3K-Akt pathway: its functions and alterations in human cancer.
  Journal
Apoptosis 9:667-76 (2004)
DOI:10.1023/B:APPT.0000045801.15585.dd
Reference
PMID:17360849
  Authors
Noguchi M, Ropars V, Roumestand C, Suizu F
  Title
Proto-oncogene TCL1: more than just a coactivator for Akt.
  Journal
FASEB J 21:2273-84 (2007)
DOI:10.1096/fj.06-7684com
Reference
PMID:20602996
  Authors
Lemmon MA, Schlessinger J
  Title
Cell signaling by receptor tyrosine kinases.
  Journal
Cell 141:1117-34 (2010)
DOI:10.1016/j.cell.2010.06.011
Reference
PMID:22367796
  Authors
Skaper SD
  Title
The neurotrophin family of neurotrophic factors: an overview.
  Journal
Methods Mol Biol 846:1-12 (2012)
DOI:10.1007/978-1-61779-536-7_1
Related
pathway
etf00010  Glycolysis / Gluconeogenesis
etf04010  MAPK signaling pathway
etf04012  ErbB signaling pathway
etf04062  Chemokine signaling pathway
etf04064  NF-kappa B signaling pathway
etf04068  FoxO signaling pathway
etf04110  Cell cycle
etf04115  p53 signaling pathway
etf04150  mTOR signaling pathway
etf04210  Apoptosis
etf04370  VEGF signaling pathway
etf04510  Focal adhesion
etf04620  Toll-like receptor signaling pathway
etf04630  JAK-STAT signaling pathway
etf04662  B cell receptor signaling pathway
etf04910  Insulin signaling pathway
KO pathway
ko04151   
LinkDB

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