Entry
Name
Cytokine-cytokine receptor interaction - Galeopterus variegatus (Sunda flying lemur)
Description
Cytokines are soluble extracellular proteins or glycoproteins that are crucial intercellular regulators and mobilizers of cells engaged in innate as well as adaptive inflammatory host defenses, cell growth, differentiation, cell death, angiogenesis, and development and repair processes aimed at the restoration of homeostasis. Cytokines are released by various cells in the body, usually in response to an activating stimulus, and they induce responses through binding to specific receptors on the cell surface of target cells. Cytokines can be grouped by structure into different families and their receptors can likewise be grouped.
Class
Environmental Information Processing; Signaling molecules and interaction
BRITE hierarchy
Pathway map
gvr04060 Cytokine-cytokine receptor interaction
Organism
Galeopterus variegatus (Sunda flying lemur) [GN:
gvr ]
Gene
103582159 NGFR; tumor necrosis factor receptor superfamily member 16 [KO:K02583 ]
103585133 IL27RA; interleukin-27 receptor subunit alpha isoform X1 [KO:K19598 ]
103585359 TNFRSF12A; tumor necrosis factor receptor superfamily member 12A [KO:K05149 ]
103585638 CSF1; macrophage colony-stimulating factor 1 isoform X1 [KO:K05453 ]
103585789 TNFSF10; tumor necrosis factor ligand superfamily member 10 [KO:K04721 ]
103585914 TNFRSF25; tumor necrosis factor receptor superfamily member 25 [KO:K05160 ]
103586806 CSF2RA; granulocyte-macrophage colony-stimulating factor receptor subunit alpha [KO:K05066 ]
103587140 RELT; tumor necrosis factor receptor superfamily member 19L [KO:K05156 ]
103587832 IL13RA1; interleukin-13 receptor subunit alpha-1 isoform X1 [KO:K05076 ]
103588371 IL6ST; interleukin-6 receptor subunit beta isoform X1 [KO:K05060 ]
103589570 CD40; tumor necrosis factor receptor superfamily member 5 isoform X1 [KO:K03160 ]
103590058 CSF2; granulocyte-macrophage colony-stimulating factor [KO:K05427 ]
103591411 TNFSF13; tumor necrosis factor ligand superfamily member 13 [KO:K05475 ]
103591412 TNFSF12; tumor necrosis factor ligand superfamily member 12 isoform X1 [KO:K05474 ]
103591610 IL20RA; interleukin-20 receptor subunit alpha isoform X1 [KO:K05136 ]
103591922 TNFRSF13C; tumor necrosis factor receptor superfamily member 13C [KO:K05151 ]
103592524 TNFRSF10A; tumor necrosis factor receptor superfamily member 10A [KO:K04722 ]
103592939 TNFSF9; tumor necrosis factor ligand superfamily member 9 [KO:K05472 ]
103593122 EDAR; tumor necrosis factor receptor superfamily member EDAR [KO:K05162 ]
103593685 IL12RB1; LOW QUALITY PROTEIN: interleukin-12 receptor subunit beta-1 [KO:K05063 ]
103594158 TNFRSF14; tumor necrosis factor receptor superfamily member 14 [KO:K05152 ]
103594871 TNFRSF4; tumor necrosis factor receptor superfamily member 4 [KO:K05142 ]
103594880 TNFRSF18; tumor necrosis factor receptor superfamily member 18 [KO:K05154 ]
103595585 TNFRSF13B; tumor necrosis factor receptor superfamily member 13B [KO:K05150 ]
103595758 IL36RN; interleukin-36 receptor antagonist protein isoform X1 [KO:K05483 ]
103596526 GDF1; LOW QUALITY PROTEIN: embryonic growth/differentiation factor 1 [KO:K05495 ]
103597104 TNFRSF11B; tumor necrosis factor receptor superfamily member 11B [KO:K05148 ]
103597807 TNFRSF19; tumor necrosis factor receptor superfamily member 19 [KO:K05155 ]
103597810 TNFRSF11A; tumor necrosis factor receptor superfamily member 11A [KO:K05147 ]
103598093 CSF3; granulocyte colony-stimulating factor isoform X1 [KO:K05423 ]
103599525 TNFSF14; tumor necrosis factor ligand superfamily member 14 isoform X1 [KO:K05477 ]
103599674 IL1RAP; interleukin-1 receptor accessory protein isoform X1 [KO:K04723 ]
103603887 EDA2R; LOW QUALITY PROTEIN: tumor necrosis factor receptor superfamily member 27 [KO:K05163 ]
103604014 TNFSF8; tumor necrosis factor ligand superfamily member 8 [KO:K05471 ]
103605089 TNFRSF1B; tumor necrosis factor receptor superfamily member 1B [KO:K05141 ]
103605099 TNFRSF8; tumor necrosis factor receptor superfamily member 8 isoform X1 [KO:K05145 ]
103605117 LTBR; tumor necrosis factor receptor superfamily member 3 [KO:K03159 ]
103605130 IL12A; LOW QUALITY PROTEIN: interleukin-12 subunit alpha [KO:K05406 ]
103605365 TNFRSF1A; tumor necrosis factor receptor superfamily member 1A [KO:K03158 ]
103605685 CNTFR; ciliary neurotrophic factor receptor subunit alpha isoform X1 [KO:K05059 ]
103605950 FASLG; tumor necrosis factor ligand superfamily member 6 [KO:K04389 ]
103606070 CSF3R; granulocyte colony-stimulating factor receptor [KO:K05061 ]
103606089 TNFSF13B; tumor necrosis factor ligand superfamily member 13B isoform X1 [KO:K05476 ]
103606304 TNFSF15; tumor necrosis factor ligand superfamily member 15 [KO:K05478 ]
103606471 CXCR3; LOW QUALITY PROTEIN: C-X-C chemokine receptor type 3 [KO:K04188 ]
103607184 FAS; tumor necrosis factor receptor superfamily member 6 [KO:K04390 ]
103607291 TNFRSF17; tumor necrosis factor receptor superfamily member 17 [KO:K05153 ]
103608552 TNFSF4; tumor necrosis factor ligand superfamily member 4 [KO:K05469 ]
103608964 TNFSF11; tumor necrosis factor ligand superfamily member 11 [KO:K05473 ]
103609571 TNFRSF9; tumor necrosis factor receptor superfamily member 9 [KO:K05146 ]
103609610 TNFSF18; LOW QUALITY PROTEIN: tumor necrosis factor ligand superfamily member 18 [KO:K05479 ]
Reference
Authors
Turner MD, Nedjai B, Hurst T, Pennington DJ
Title
Cytokines and chemokines: At the crossroads of cell signalling and inflammatory disease.
Journal
Reference
Authors
Brocker C, Thompson D, Matsumoto A, Nebert DW, Vasiliou V
Title
Evolutionary divergence and functions of the human interleukin (IL) gene family.
Journal
Reference
Authors
Akdis M, Aab A, Altunbulakli C, Azkur K, Costa RA, Crameri R, Duan S, Eiwegger T, Eljaszewicz A, Ferstl R, Frei R, Garbani M, Globinska A, Hess L, Huitema C, Kubo T, Komlosi Z, Konieczna P, Kovacs N, Kucuksezer UC, Meyer N, Morita H, Olzhausen J, O'Mahony L, Pezer M, Prati M, Rebane A, Rhyner C, Rinaldi A, Sokolowska M, Stanic B, Sugita K, Treis A, van de Veen W, Wanke K, Wawrzyniak M, Wawrzyniak P, Wirz OF, Zakzuk JS, Akdis CA
Title
Interleukins (from IL-1 to IL-38), interferons, transforming growth factor beta, and TNF-alpha: Receptors, functions, and roles in diseases.
Journal
Reference
Authors
Boulanger MJ, Garcia KC
Title
Shared cytokine signaling receptors: structural insights from the gp130 system.
Journal
Reference
Authors
Allan SM, Tyrrell PJ, Rothwell NJ
Title
Interleukin-1 and neuronal injury.
Journal
Reference
Authors
Lopetuso LR, Chowdhry S, Pizarro TT
Title
Opposing Functions of Classic and Novel IL-1 Family Members in Gut Health and Disease.
Journal
Reference
Authors
Iwakura Y, Ishigame H, Saijo S, Nakae S
Title
Functional specialization of interleukin-17 family members.
Journal
Reference
Authors
Fischer P, Hilfiker-Kleiner D
Title
Survival pathways in hypertrophy and heart failure: the gp130-STAT3 axis.
Journal
Reference
Authors
Richards CD
Title
The enigmatic cytokine oncostatin m and roles in disease.
Journal
Reference
Authors
Zhang Q, Putheti P, Zhou Q, Liu Q, Gao W
Title
Structures and biological functions of IL-31 and IL-31 receptors.
Journal
Reference
Authors
Meenhuis A, Verwijmeren C, Roovers O, Touw IP
Title
The deubiquitinating enzyme DUB2A enhances CSF3 signalling by attenuating lysosomal routing of the CSF3 receptor.
Journal
Reference
Authors
de Weerd NA, Nguyen T
Title
The interferons and their receptors--distribution and regulation.
Journal
Reference
Authors
Aggarwal BB
Title
Signalling pathways of the TNF superfamily: a double-edged sword.
Journal
Reference
Authors
Ashkenazi A
Title
Targeting death and decoy receptors of the tumour-necrosis factor superfamily.
Journal
Reference
Authors
Seeger P, Musso T, Sozzani S
Title
The TGF-beta superfamily in dendritic cell biology.
Journal
Reference
Authors
Wakefield LM, Hill CS
Title
Beyond TGFbeta: roles of other TGFbeta superfamily members in cancer.
Journal
Reference
Authors
Mueller TD, Nickel J
Title
Promiscuity and specificity in BMP receptor activation.
Journal
KO pathway