KEGG   PATHWAY: hmh04020
Entry
hmh04020                    Pathway                                
Name
Calcium signaling pathway - Hylobates moloch (silvery gibbon)
Description
Ca2+ that enters the cell from the outside is a principal source of signal Ca2+. Entry of Ca2+ is driven by the presence of a large electrochemical gradient across the plasma membrane. Cells use this external source of signal Ca2+ by activating various entry channels with widely different properties. The voltage-operated channels (VOCs) are found in excitable cells and generate the rapid Ca2+ fluxes that control fast cellular processes. There are many other Ca2+-entry channels, such as the receptor-operated channels (ROCs), for example the NMDA (N-methyl-D-aspartate) receptors (NMDARs) that respond to glutamate. There also are second-messenger-operated channels (SMOCs) and store-operated channels (SOCs).
The other principal source of Ca2+ for signalling is the internal stores that are located primarily in the endoplasmic/sarcoplasmic reticulum (ER/SR), in which inositol-1,4,5-trisphosphate receptors (IP3Rs) or ryanodine receptors (RYRs) regulate the release of Ca2+. The principal activator of these channels is Ca2+ itself and this process of Ca2+-induced Ca2+ release is central to the mechanism of Ca2+ signalling. Various second messengers or modulators also control the release of Ca2+. IP3, which is generated by pathways using different isoforms of phospholipase C (PLCbeta, delta, epsilon, gamma and zeta), regulates the IP3Rs. Cyclic ADP-ribose (cADPR) releases Ca2+ via RYRs. Nicotinic acid adenine dinucleotide phosphate (NAADP) may activate a distinct Ca2+ release mechanism on separate acidic Ca2+ stores. Ca2+ release via the NAADP-sensitive mechanism may also feedback onto either RYRs or IP3Rs. cADPR and NAADP are generated by CD38. This enzyme might be sensitive to the cellular metabolism, as ATP and NADH inhibit it.
The influx of Ca2+ from the environment or release from internal stores causes a very rapid and dramatic increase in cytoplasmic calcium concentration, which has been widely exploited for signal transduction. Some proteins, such as troponin C (TnC) involved in muscle contraction, directly bind to and sense Ca2+. However, in other cases Ca2+ is sensed through intermediate calcium sensors such as calmodulin (CALM).
Class
Environmental Information Processing; Signal transduction
Pathway map
hmh04020  Calcium signaling pathway
hmh04020

Other DBs
GO: 0019722
Organism
Hylobates moloch (silvery gibbon) [GN:hmh]
Gene
116456678  FGF10; fibroblast growth factor 10 [KO:K04358]
116456680  STIM2; stromal interaction molecule 2 isoform X1 [KO:K18196]
116456707  FGFR3; fibroblast growth factor receptor 3 isoform X5 [KO:K05094] [EC:2.7.10.1]
116456825  DRD5; D(1B) dopamine receptor [KO:K05840]
116456838  CD38; ADP-ribosyl cyclase/cyclic ADP-ribose hydrolase 1 [KO:K01242] [EC:3.2.2.6 2.4.99.20]
116456961  GDNF; glial cell line-derived neurotrophic factor [KO:K05452]
116457004  CCKAR; cholecystokinin receptor type A [KO:K04194]
116457100  ADCY2; LOW QUALITY PROTEIN: adenylate cyclase type 2 [KO:K08042] [EC:4.6.1.1]
116457220  ITPKB; inositol-trisphosphate 3-kinase B [KO:K00911] [EC:2.7.1.127]
116457249  ATP2B4; plasma membrane calcium-transporting ATPase 4 isoform X1 [KO:K05850] [EC:7.2.2.10]
116457306  PLCE1; 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase epsilon-1 isoform X2 [KO:K05860] [EC:3.1.4.11]
116457338  CACNA1S; voltage-dependent L-type calcium channel subunit alpha-1S [KO:K04857]
116457404  CAMK1G; calcium/calmodulin-dependent protein kinase type 1G [KO:K08794] [EC:2.7.11.17]
116457812  AVPR1B; vasopressin V1b receptor [KO:K04227]
116457963  CACNA1E; voltage-dependent R-type calcium channel subunit alpha-1E [KO:K04852]
116458043  CHRM3; muscarinic acetylcholine receptor M3 [KO:K04131]
116458053  RYR2; ryanodine receptor 2 isoform X6 [KO:K04962]
116458307  MRLN; myoregulin [KO:K22643]
116458418  PRKACG; LOW QUALITY PROTEIN: cAMP-dependent protein kinase catalytic subunit gamma [KO:K04345] [EC:2.7.11.11]
116458508  P2RX1; P2X purinoceptor 1 [KO:K05215]
116458509  ATP2A3; sarcoplasmic/endoplasmic reticulum calcium ATPase 3 isoform X1 [KO:K05853] [EC:7.2.2.10]
116458615  CACNA1I; voltage-dependent T-type calcium channel subunit alpha-1I isoform X1 [KO:K04856]
116458711  PDGFB; platelet-derived growth factor subunit B [KO:K17386]
116458860  TACR2; substance-K receptor [KO:K04223]
116458866  P2RX5; P2X purinoceptor 5 isoform X1 [KO:K05219]
116458912  P2RX6; P2X purinoceptor 6 isoform X7 [KO:K05221]
116459149  ADORA2A; LOW QUALITY PROTEIN: adenosine receptor A2a [KO:K04266]
116459475  PPP3CB; serine/threonine-protein phosphatase 2B catalytic subunit beta isoform isoform X1 [KO:K04348] [EC:3.1.3.16]
116459671  ITPR3; inositol 1,4,5-trisphosphate receptor type 3 isoform X1 [KO:K04960]
116459675  CAMK2G; calcium/calmodulin-dependent protein kinase type II subunit gamma isoform X1 [KO:K04515] [EC:2.7.11.17]
116459730  TFEB; transcription factor EB [KO:K15590]
116459737  VEGFA; vascular endothelial growth factor A, long form isoform X1 [KO:K05448]
116459824  MYLK4; myosin light chain kinase family member 4 isoform X1 [KO:K00907] [EC:2.7.11.18]
116459956  VDAC2; voltage-dependent anion-selective channel protein 2 [KO:K15040]
116460298  PPIF; peptidyl-prolyl cis-trans isomerase F, mitochondrial [KO:K09565] [EC:5.2.1.8]
116460949  MYLK2; myosin light chain kinase 2, skeletal/cardiac muscle [KO:K00907] [EC:2.7.11.18]
116461010  PLCG1; 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1 isoform X1 [KO:K01116] [EC:3.1.4.11]
116461045  NFATC2; nuclear factor of activated T-cells, cytoplasmic 2 isoform X1 [KO:K17332]
116461202  PLCB4; 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-4 isoform X1 [KO:K05858] [EC:3.1.4.11]
116461239  NTSR1; neurotensin receptor type 1 [KO:K04211]
116461249  ADRA1D; alpha-1D adrenergic receptor [KO:K04137]
116461332  RET; proto-oncogene tyrosine-protein kinase receptor Ret isoform X1 [KO:K05126] [EC:2.7.10.1]
116461370  PLCB1; 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-1 isoform X2 [KO:K05858] [EC:3.1.4.11]
116461702  ADRA1A; alpha-1A adrenergic receptor [KO:K04135]
116461788  ADRB3; beta-3 adrenergic receptor [KO:K04143]
116461833  VDAC3; voltage-dependent anion-selective channel protein 3 isoform X1 [KO:K15041]
116461844  PPP3CC; serine/threonine-protein phosphatase 2B catalytic subunit gamma isoform isoform X1 [KO:K04348] [EC:3.1.3.16]
116461936  FGF17; fibroblast growth factor 17 isoform X1 [KO:K04358]
116461989  PTK2B; protein-tyrosine kinase 2-beta isoform X1 [KO:K05871] [EC:2.7.10.2]
116462129  FGFR1; fibroblast growth factor receptor 1 isoform X1 [KO:K04362] [EC:2.7.10.1]
116462297  ADCY9; adenylate cyclase type 9 isoform X2 [KO:K08049] [EC:4.6.1.1]
116462356  CACNA1H; voltage-dependent T-type calcium channel subunit alpha-1H isoform X1 [KO:K04855]
116462359  GRIN2A; glutamate receptor ionotropic, NMDA 2A isoform X1 [KO:K05209]
116462877  [KO:K04161]
116462920  CXCR4; C-X-C chemokine receptor type 4 isoform X1 [KO:K04189]
116462932  PDGFA; platelet-derived growth factor subunit A isoform X1 [KO:K04359]
116463099  CAMK2D; calcium/calmodulin-dependent protein kinase type II subunit delta isoform X2 [KO:K04515] [EC:2.7.11.17]
116463111  [KO:K04603]
116463144  [KO:K04603]
116463273  [KO:K04632]
116463274  [KO:K04632]
116463360  [KO:K04632]
116463361  [KO:K04632]
116463423  CUNH4orf3; uncharacterized protein C4orf3 homolog [KO:K26467]
116463464  [KO:K05450]
116463488  [KO:K05450]
116463600  FGF2; fibroblast growth factor 2 [KO:K18497]
116463675  [KO:K20858]
116463690  [KO:K20858]
116463821  [KO:K04267]
116463827  [KO:K04267]
116463829  SLC25A31; ADP/ATP translocase 4 [KO:K05863]
116464064  PHKG1; phosphorylase b kinase gamma catalytic chain, skeletal muscle/heart isoform isoform X1 [KO:K00871] [EC:2.7.11.19]
116464198  [KO:K05849]
116464199  [KO:K05849]
116466046  VEGFC; vascular endothelial growth factor C isoform X1 [KO:K05449]
116466073  SLC25A4; ADP/ATP translocase 1 [KO:K05863]
116466374  FGF5; fibroblast growth factor 5 isoform X1 [KO:K04358]
116466681  ITPR1; inositol 1,4,5-trisphosphate receptor type 1 isoform X1 [KO:K04958]
116466695  OXTR; oxytocin receptor [KO:K04229]
116466718  CAMK1; calcium/calmodulin-dependent protein kinase type 1 isoform X1 [KO:K08794] [EC:2.7.11.17]
116466736  ATP2B2; plasma membrane calcium-transporting ATPase 2 isoform X1 [KO:K05850] [EC:7.2.2.10]
116466741  HRH1; histamine H1 receptor [KO:K04149]
116466848  MYLK; myosin light chain kinase, smooth muscle isoform X3 [KO:K00907] [EC:2.7.11.18]
116466871  [KO:K02183]
116467120  FLT1; vascular endothelial growth factor receptor 1 isoform X1 [KO:K05096] [EC:2.7.10.1]
116467157  FGF9; fibroblast growth factor 9 [KO:K04358]
116467252  HTR2A; 5-hydroxytryptamine receptor 2A isoform X2 [KO:K04157]
116467268  CYSLTR2; cysteinyl leukotriene receptor 2 isoform X2 [KO:K04323]
116467343  PDGFRA; platelet-derived growth factor receptor alpha [KO:K04363] [EC:2.7.10.1]
116467366  EDNRB; endothelin receptor type B [KO:K04198]
116467516  [KO:K02183]
116467558  KDR; vascular endothelial growth factor receptor 2 [KO:K05098] [EC:2.7.10.1]
116467918  NTRK1; high affinity nerve growth factor receptor [KO:K03176] [EC:2.7.10.1]
116468256  FGF19; fibroblast growth factor 19 [KO:K22603]
116468258  FGF4; fibroblast growth factor 4 [KO:K04358]
116468259  FGF3; fibroblast growth factor 3 [KO:K04358]
116468350  NGF; beta-nerve growth factor [KO:K02582]
116468452  NFATC1; nuclear factor of activated T-cells, cytoplasmic 1 isoform X1 [KO:K04446]
116468756  GNAL; guanine nucleotide-binding protein G(olf) subunit alpha isoform X1 [KO:K04633]
116468794  P2RX3; P2X purinoceptor 3 isoform X3 [KO:K05217]
116468912  CHRM1; muscarinic acetylcholine receptor M1 [KO:K04129]
116468938  PLCB3; 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-3 [KO:K05858] [EC:3.1.4.11]
116468948  VEGFB; vascular endothelial growth factor B isoform X1 [KO:K16858]
116469112  TPCN2; two pore channel protein 2 isoform X1 [KO:K14077]
116469213  CASQ1; calsequestrin-1 [KO:K23468]
116469561  CASQ2; calsequestrin-2 [KO:K23445]
116469831  MCOLN3; mucolipin-3 isoform X1 [KO:K04994]
116469832  MCOLN2; mucolipin-2 isoform X1 [KO:K04993]
116469844  PRKACB; cAMP-dependent protein kinase catalytic subunit beta isoform X1 [KO:K04345] [EC:2.7.11.11]
116469851  PTGFR; prostaglandin F2-alpha receptor isoform X1 [KO:K04262]
116469897  PTGER3; prostaglandin E2 receptor EP3 subtype isoform X1 [KO:K04260]
116470186  ATP2A1; sarcoplasmic/endoplasmic reticulum calcium ATPase 1 isoform X2 [KO:K05853] [EC:7.2.2.10]
116470224  PHKG2; phosphorylase b kinase gamma catalytic chain, liver/testis isoform [KO:K00871] [EC:2.7.11.19]
116470570  [KO:K00871] [EC:2.7.11.19]
116470775  PLCG2; 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-2 isoform X1 [KO:K05859] [EC:3.1.4.11]
116470946  CAMK4; calcium/calmodulin-dependent protein kinase type IV [KO:K05869] [EC:2.7.11.17]
116471090  F2R; proteinase-activated receptor 1 [KO:K03914]
116471147  PRKCB; protein kinase C beta type isoform X1 [KO:K19662] [EC:2.7.11.13]
116471177  ORAI3; protein orai-3 [KO:K16058]
116471214  PHKB; phosphorylase b kinase regulatory subunit beta isoform X1 [KO:K07190]
116471246  ADCY7; adenylate cyclase type 7 isoform X1 [KO:K08047] [EC:4.6.1.1]
116471414  NFATC3; nuclear factor of activated T-cells, cytoplasmic 3 isoform X2 [KO:K17333]
116471452  PLN; cardiac phospholamban isoform X4 [KO:K05852]
116471501  VDAC1; voltage-dependent anion-selective channel protein 1 [KO:K05862]
116471633  TRDN; triadin isoform X1 [KO:K23449]
116471654  FGF1; LOW QUALITY PROTEIN: fibroblast growth factor 1 [KO:K18496]
116471690  HTR4; 5-hydroxytryptamine receptor 4 isoform X1 [KO:K04160]
116471691  ADRB2; beta-2 adrenergic receptor [KO:K04142]
116471711  PDGFRB; platelet-derived growth factor receptor beta [KO:K05089] [EC:2.7.10.1]
116471714  CAMK2A; calcium/calmodulin-dependent protein kinase type II subunit alpha isoform X1 [KO:K04515] [EC:2.7.11.17]
116471787  ADRA1B; alpha-1B adrenergic receptor isoform X2 [KO:K04136]
116471846  FGF18; fibroblast growth factor 18 isoform X1 [KO:K04358]
116471873  DRD1; D(1A) dopamine receptor [KO:K04144]
116471875  HRH2; histamine H2 receptor isoform X2 [KO:K04150]
116471901  FGFR4; fibroblast growth factor receptor 4 [KO:K05095] [EC:2.7.10.1]
116471959  FLT4; vascular endothelial growth factor receptor 3 isoform X1 [KO:K05097] [EC:2.7.10.1]
116472213  FGF23; fibroblast growth factor 23 [KO:K22428]
116472238  PLCZ1; 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase zeta-1 isoform X1 [KO:K05861] [EC:3.1.4.11]
116472375  FGF20; fibroblast growth factor 20 [KO:K04358]
116472525  CACNA1C; voltage-dependent L-type calcium channel subunit alpha-1C isoform X1 [KO:K04850]
116472553  FGF6; fibroblast growth factor 6 [KO:K04358]
116472713  GRIN2B; glutamate receptor ionotropic, NMDA 2B [KO:K05210]
116472793  ITPR2; inositol 1,4,5-trisphosphate receptor type 2 [KO:K04959]
116473215  CAMK1D; calcium/calmodulin-dependent protein kinase type 1D isoform X2 [KO:K08794] [EC:2.7.11.17]
116473372  CACNA1D; voltage-dependent L-type calcium channel subunit alpha-1D isoform X9 [KO:K04851]
116473397  TNNC1; troponin C, slow skeletal and cardiac muscles [KO:K05865]
116473450  MST1R; macrophage-stimulating protein receptor isoform X1 [KO:K05100] [EC:2.7.10.1]
116473462  MST1; hepatocyte growth factor-like protein isoform X1 [KO:K23441]
116473664  PLCD1; 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase delta-1 isoform X1 [KO:K05857] [EC:3.1.4.11]
116474359  CACNA1G; voltage-dependent T-type calcium channel subunit alpha-1G isoform X5 [KO:K04854]
116474613  CALML5; calmodulin-like protein 5 [KO:K02183]
116474621  CALML3; calmodulin-like protein 3 [KO:K02183]
116474634  NOS2; nitric oxide synthase, inducible [KO:K13241] [EC:1.14.13.39]
116474757  ERBB2; receptor tyrosine-protein kinase erbB-2 isoform X1 [KO:K05083] [EC:2.7.10.1]
116474968  PLCD3; 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase delta-3 isoform X1 [KO:K05857] [EC:3.1.4.11]
116475175  GNA14; guanine nucleotide-binding protein subunit alpha-14 [KO:K04636]
116475178  GNAQ; guanine nucleotide-binding protein G(q) subunit alpha [KO:K04634]
116475199  NTRK2; BDNF/NT-3 growth factors receptor isoform X2 [KO:K04360] [EC:2.7.10.1]
116475347  GRIN3A; glutamate receptor ionotropic, NMDA 3A [KO:K05213]
116475348  PPP3R2; calcineurin subunit B type 2 [KO:K06268]
116475911  GRIN1; glutamate receptor ionotropic, NMDA 1 isoform X2 [KO:K05208]
116475947  CACNA1B; voltage-dependent N-type calcium channel subunit alpha-1B isoform X1 [KO:K04849]
116476592  CCKBR; gastrin/cholecystokinin type B receptor isoform X1 [KO:K04195]
116476612  STIM1; stromal interaction molecule 1 isoform X1 [KO:K16059]
116476794  GRM5; metabotropic glutamate receptor 5 isoform X1 [KO:K04604]
116476871  PDGFD; platelet-derived growth factor D isoform X1 [KO:K05450]
116477427  SLN; sarcolipin [KO:K22642]
116477658  P2RX2; P2X purinoceptor 2 isoform X1 [KO:K05216]
116477786  ORAI1; calcium release-activated calcium channel protein 1 [KO:K16056]
116477795  P2RX7; P2X purinoceptor 7 [KO:K05220]
116477796  P2RX4; P2X purinoceptor 4 [KO:K05218]
116477857  NOS1; nitric oxide synthase 1 isoform X2 [KO:K13240] [EC:1.14.13.39]
116477879  TPCN1; two pore channel protein 1 isoform X3 [KO:K16896]
116477947  ATP2A2; sarcoplasmic/endoplasmic reticulum calcium ATPase 2 [KO:K05853] [EC:7.2.2.10]
116478190  HRC; sarcoplasmic reticulum histidine-rich calcium-binding protein [KO:K23450]
116478244  SPHK2; sphingosine kinase 2 isoform X2 [KO:K04718] [EC:2.7.1.91]
116478253  GRIN2D; glutamate receptor ionotropic, NMDA 2D [KO:K05212]
116478308  CALM3; calmodulin-3 [KO:K02183]
116478352  MCOLN1; mucolipin-1 [KO:K04992]
116478572  CACNA1A; voltage-dependent P/Q-type calcium channel subunit alpha-1A isoform X2 [KO:K04344]
116478588  PRKACA; cAMP-dependent protein kinase catalytic subunit alpha isoform X1 [KO:K04345] [EC:2.7.11.11]
116478596  PTGER1; prostaglandin E2 receptor EP1 subtype [KO:K04258]
116478714  HTR7; 5-hydroxytryptamine receptor 7 isoform X2 [KO:K04163]
116479072  ATP2B1; plasma membrane calcium-transporting ATPase 1 isoform X1 [KO:K05850] [EC:7.2.2.10]
116479165  PRKCG; protein kinase C gamma type [KO:K19663] [EC:2.7.11.13]
116479721  EGF; pro-epidermal growth factor isoform X1 [KO:K04357]
116479726  FGF21; fibroblast growth factor 21 [KO:K22429]
116480045  RYR1; ryanodine receptor 1 [KO:K04961]
116480173  AVPR1A; vasopressin V1a receptor [KO:K04226]
116480239  AGTR1; type-1 angiotensin II receptor [KO:K04166]
116480405  ADCY3; adenylate cyclase type 3 isoform X1 [KO:K08043] [EC:4.6.1.1]
116480667  ITPKC; inositol-trisphosphate 3-kinase C [KO:K00911] [EC:2.7.1.127]
116480929  ERBB3; receptor tyrosine-protein kinase erbB-3 [KO:K05084] [EC:2.7.10.1]
116480961  PDE1B; dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1B isoform X1 [KO:K13755] [EC:3.1.4.17]
116481518  ITPKA; inositol-trisphosphate 3-kinase A [KO:K00911] [EC:2.7.1.127]
116481815  TACR3; neuromedin-K receptor [KO:K04224]
116481969  PLCB2; 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-2 isoform X6 [KO:K05858] [EC:3.1.4.11]
116482010  [KO:K04809]
116482214  NTRK3; NT-3 growth factor receptor isoform X3 [KO:K05101] [EC:2.7.10.1]
116482339  CALML4; calmodulin-like protein 4 isoform X1 [KO:K02183]
116482607  FGFR2; fibroblast growth factor receptor 2 isoform X1 [KO:K05093] [EC:2.7.10.1]
116482614  CHRM5; muscarinic acetylcholine receptor M5 [KO:K04133]
116482617  RYR3; ryanodine receptor 3 [KO:K04963]
116482647  FGF7; fibroblast growth factor 7 [KO:K04358]
116482892  LHCGR; lutropin-choriogonadotropic hormone receptor [KO:K04248]
116482899  GRIN3B; glutamate receptor ionotropic, NMDA 3B [KO:K05214]
116483058  SPHK1; sphingosine kinase 1 [KO:K04718] [EC:2.7.1.91]
116483095  GNA15; guanine nucleotide-binding protein subunit alpha-15 [KO:K04637]
116483096  GNA11; guanine nucleotide-binding protein subunit alpha-11 [KO:K04635]
116483146  CALM2; calmodulin-2 isoform X1 [KO:K02183]
116483376  ADRB1; beta-1 adrenergic receptor [KO:K04141]
116483403  SLC8A1; sodium/calcium exchanger 1 [KO:K05849]
116483405  TACR1; substance-P receptor [KO:K04222]
116483464  GRIN2C; glutamate receptor ionotropic, NMDA 2C isoform X2 [KO:K05211]
116483502  TGFA; protransforming growth factor alpha [KO:K08774]
116483520  PPP3R1; calcineurin subunit B type 1 isoform X2 [KO:K06268]
116483574  TBXA2R; thromboxane A2 receptor isoform X2 [KO:K04264]
116483814  PPP3CA; protein phosphatase 3 catalytic subunit alpha isoform X1 [KO:K04348] [EC:3.1.3.16]
116483940  FGF22; fibroblast growth factor 22 isoform X2 [KO:K04358]
116483969  PRKCA; protein kinase C alpha type [KO:K02677] [EC:2.7.11.13]
116484060  SMIM6; small integral membrane protein 6 isoform X1 [KO:K26468]
116484619  NFATC4; nuclear factor of activated T-cells, cytoplasmic 4 isoform X2 [KO:K17334]
116484687  FGF8; fibroblast growth factor 8 isoform X1 [KO:K04358]
116484728  SLC8A3; sodium/calcium exchanger 3 isoform X1 [KO:K05849]
116484977  LTB4R2; leukotriene B4 receptor 2 [KO:K04297]
116484980  ADCY4; adenylate cyclase type 4 isoform X1 [KO:K08044] [EC:4.6.1.1]
116485029  BDKRB2; B2 bradykinin receptor [KO:K03916]
116485030  BDKRB1; B1 bradykinin receptor [KO:K03915]
116485193  CALM1; calmodulin-1 isoform X2 [KO:K02183]
116809351  HTR5A; 5-hydroxytryptamine receptor 5A [KO:K04161]
116810092  HTR2B; 5-hydroxytryptamine receptor 2B [KO:K04157]
116810290  PLCD4; 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase delta-4 isoform X1 [KO:K05857] [EC:3.1.4.11]
116810355  ERBB4; receptor tyrosine-protein kinase erbB-4 isoform X5 [KO:K05085] [EC:2.7.10.1]
116810579  PDE1A; dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A isoform X3 [KO:K13755] [EC:3.1.4.17]
116810981  ORAI2; protein orai-2 [KO:K16057]
116811101  PHKA1; phosphorylase b kinase regulatory subunit alpha, skeletal muscle isoform [KO:K07190]
116811338  FGF16; fibroblast growth factor 16 [KO:K04358]
116811486  SLC25A6; ADP/ATP translocase 3 [KO:K05863]
116811530  VEGFD; vascular endothelial growth factor D [KO:K05449]
116811539  GRPR; gastrin-releasing peptide receptor [KO:K04169]
116811686  CACNA1F; voltage-dependent L-type calcium channel subunit alpha-1F isoform X1 [KO:K04853]
116811827  CYSLTR1; cysteinyl leukotriene receptor 1 [KO:K04322]
116811837  [KO:K05862]
116811969  HTR2C; 5-hydroxytryptamine receptor 2C isoform X1 [KO:K04157]
116811994  SLC25A5; ADP/ATP translocase 2 [KO:K05863]
116812065  [KO:K04632]
116812192  ATP2B3; plasma membrane calcium-transporting ATPase 3 isoform X1 [KO:K05850] [EC:7.2.2.10]
116812280  PHKA2; phosphorylase b kinase regulatory subunit alpha, liver isoform [KO:K07190]
116812436  EGFR; epidermal growth factor receptor [KO:K04361] [EC:2.7.10.1]
116812469  ADCY1; adenylate cyclase type 1 [KO:K08041] [EC:4.6.1.1]
116812488  CAMK2B; calcium/calmodulin-dependent protein kinase type II subunit beta isoform X1 [KO:K04515] [EC:2.7.11.17]
116812584  PDE1C; dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1C isoform X5 [KO:K13755] [EC:3.1.4.17]
116812692  TRHR; thyrotropin-releasing hormone receptor [KO:K04282]
116813019  HTR6; 5-hydroxytryptamine receptor 6 [KO:K04162]
116813162  PTAFR; platelet-activating factor receptor [KO:K04279]
116813254  ASPH; aspartyl/asparaginyl beta-hydroxylase isoform X1 [KO:K00476] [EC:1.14.11.16]
116813595  ADCY8; adenylate cyclase type 8 isoform X1 [KO:K08048] [EC:4.6.1.1]
116813883  CALML6; calmodulin-like protein 6 [KO:K02183]
116814273  MET; hepatocyte growth factor receptor [KO:K05099] [EC:2.7.10.1]
116814401  CHRM2; muscarinic acetylcholine receptor M2 [KO:K04130]
116814534  NOS3; nitric oxide synthase 3 isoform X1 [KO:K13242] [EC:1.14.13.39]
Compound
C00002  ATP
C00004  NADH
C00076  Calcium cation
C00165  Diacylglycerol
C00575  3',5'-Cyclic AMP
C01245  D-myo-Inositol 1,4,5-trisphosphate
C01330  Sodium cation
C06124  Sphingosine 1-phosphate
C11556  1-Phosphatidyl-1D-myo-inositol 3,5-bisphosphate
C13050  Cyclic ADP-ribose
C13051  Nicotinic acid adenine dinucleotide phosphate
Reference
PMID:12838335
  Authors
Berridge MJ, Bootman MD, Roderick HL.
  Title
Calcium signalling: dynamics, homeostasis and remodelling.
  Journal
Nat Rev Mol Cell Biol 4:517-29 (2003)
DOI:10.1038/nrm1155
Reference
PMID:11413485
  Authors
Berridge MJ, Lipp P, Bootman MD.
  Title
The versatility and universality of calcium signalling.
  Journal
Nat Rev Mol Cell Biol 1:11-21 (2000)
DOI:10.1038/35036035
Reference
PMID:15111104
  Authors
Wang MC, Dolphin A, Kitmitto A.
  Title
L-type voltage-gated calcium channels: understanding function through structure.
  Journal
FEBS Lett 564:245-50 (2004)
DOI:10.1016/S0014-5793(04)00253-4
Reference
PMID:11299192
  Authors
Ferrier GR, Howlett SE.
  Title
Cardiac excitation-contraction coupling: role of membrane potential in regulation of contraction.
  Journal
Am J Physiol Heart Circ Physiol 280:H1928-44 (2001)
DOI:10.1152/ajpheart.2001.280.5.H1928
Reference
PMID:11698232
  Authors
Keef KD, Hume JR, Zhong J.
  Title
Regulation of cardiac and smooth muscle Ca(2+) channels (Ca(V)1.2a,b) by protein kinases.
  Journal
Am J Physiol Cell Physiol 281:C1743-56 (2001)
DOI:10.1152/ajpcell.2001.281.6.C1743
Reference
PMID:8125957
  Authors
Hell JW, Appleyard SM, Yokoyama CT, Warner C, Catterall WA.
  Title
Differential phosphorylation of two size forms of the N-type calcium channel alpha 1 subunit which have different COOH termini.
  Journal
J Biol Chem 269:7390-6 (1994)
Reference
PMID:15000521
  Authors
Yunker AM.
  Title
Modulation and pharmacology of low voltage-activated ("T-Type") calcium channels.
  Journal
J Bioenerg Biomembr 35:577-98 (2003)
DOI:10.1023/B:JOBB.0000008025.65675.37
Reference
PMID:9149541
  Authors
Yakel JL.
  Title
Calcineurin regulation of synaptic function: from ion channels to transmitter release and gene transcription.
  Journal
Trends Pharmacol Sci 18:124-34 (1997)
DOI:10.1016/S0165-6147(97)01046-8
Reference
PMID:10997573
  Authors
Fukunaga K, Miyamoto E.
  Title
A working model of CaM kinase II activity in hippocampal long-term potentiation and memory.
  Journal
Neurosci Res 38:3-17 (2000)
DOI:10.1016/S0168-0102(00)00139-5
Reference
PMID:9235901
  Authors
Della Rocca GJ, van Biesen T, Daaka Y, Luttrell DK, Luttrell LM, Lefkowitz RJ.
  Title
Ras-dependent mitogen-activated protein kinase activation by G protein-coupled receptors. Convergence of Gi- and Gq-mediated pathways on calcium/calmodulin, Pyk2, and Src kinase.
  Journal
J Biol Chem 272:19125-32 (1997)
DOI:10.1074/jbc.272.31.19125
Reference
PMID:7861177
  Authors
Furuichi T, Mikoshiba K.
  Title
Inositol 1, 4, 5-trisphosphate receptor-mediated Ca2+ signaling in the brain.
  Journal
J Neurochem 64:953-60 (1995)
DOI:10.1046/j.1471-4159.1995.64030953.x
Reference
PMID:14572802
  Authors
Bruce JI, Straub SV, Yule DI.
  Title
Crosstalk between cAMP and Ca2+ signaling in non-excitable cells.
  Journal
Cell Calcium 34:431-44 (2003)
DOI:10.1016/S0143-4160(03)00150-7
Reference
PMID:10331643
  Authors
Lee HC, Munshi C, Graeff R.
  Title
Structures and activities of cyclic ADP-ribose, NAADP and their metabolic enzymes.
  Journal
Mol Cell Biochem 193:89-98 (1999)
DOI:10.1007/978-1-4419-8740-2_13
Reference
PMID:11080247
  Authors
Crompton M.
  Title
Mitochondrial intermembrane junctional complexes and their role in cell death.
  Journal
J Physiol 529 Pt 1:11-21 (2000)
DOI:10.1111/j.1469-7793.2000.00011.x
Reference
PMID:10508738
  Authors
Grewal SS, York RD, Stork PJ.
  Title
Extracellular-signal-regulated kinase signalling in neurons.
  Journal
Curr Opin Neurobiol 9:544-53 (1999)
DOI:10.1016/S0959-4388(99)00010-0
Reference
PMID:12972622
  Authors
Trushin SA, Pennington KN, Carmona EM, Asin S, Savoy DN, Billadeau DD, Paya CV.
  Title
Protein kinase Calpha (PKCalpha) acts upstream of PKCtheta to activate IkappaB kinase and NF-kappaB in T lymphocytes.
  Journal
Mol Cell Biol 23:7068-81 (2003)
DOI:10.1128/MCB.23.19.7068-7081.2003
Reference
PMID:14517314
  Authors
Hutchins JR, Dikovskaya D, Clarke PR.
  Title
Regulation of Cdc2/cyclin B activation in Xenopus egg extracts via inhibitory phosphorylation of Cdc25C phosphatase by Ca(2+)/calmodulin-dependent protein [corrected] kinase II.
  Journal
Mol Biol Cell 14:4003-14 (2003)
DOI:10.1091/mbc.E03-02-0061
Reference
PMID:21338471
  Authors
Tornquist K
  Title
Sphingosine 1-phosphate, sphingosine kinase and autocrine calcium signalling in thyroid cells.
  Journal
Acta Physiol (Oxf) 204:151-7 (2012)
DOI:10.1111/j.1748-1716.2011.02265.x
Reference
PMID:22129055
  Authors
Feske S
  Title
Immunodeficiency due to defects in store-operated calcium entry.
  Journal
Ann N Y Acad Sci 1238:74-90 (2011)
DOI:10.1111/j.1749-6632.2011.06240.x
Reference
PMID:22002090
  Authors
Giachini FR, Lima VV, Hannan JL, Carneiro FS, Webb RC, Tostes RC
  Title
STIM1/Orai1-mediated store-operated Ca2+ entry: the tip of the iceberg.
  Journal
Braz J Med Biol Res 44:1080-7 (2011)
DOI:10.1590/S0100-879X2011007500133
Reference
PMID:19172794
  Authors
Baba Y, Kurosaki T
  Title
[Regulation of store-operated calcium entry by STIM1].
  Journal
Seikagaku 80:1123-8 (2008)
Reference
PMID:19475418
  Authors
Galione A, Evans AM, Ma J, Parrington J, Arredouani A, Cheng X, Zhu MX
  Title
The acid test: the discovery of two-pore channels (TPCs) as NAADP-gated endolysosomal Ca(2+) release channels.
  Journal
Pflugers Arch 458:869-76 (2009)
DOI:10.1007/s00424-009-0682-y
Reference
PMID:19434403
  Authors
Beard NA, Wei L, Dulhunty AF
  Title
Ca(2+) signaling in striated muscle: the elusive roles of triadin, junctin, and calsequestrin.
  Journal
Eur Biophys J 39:27-36 (2009)
DOI:10.1007/s00249-009-0449-6
Reference
PMID:26228554
  Authors
Marty I
  Title
Triadin regulation of the ryanodine receptor complex.
  Journal
J Physiol 593:3261-6 (2015)
DOI:10.1113/jphysiol.2014.281147
Reference
PMID:20807542
  Authors
Arvanitis DA, Vafiadaki E, Sanoudou D, Kranias EG
  Title
Histidine-rich calcium binding protein: the new regulator of sarcoplasmic reticulum calcium cycling.
  Journal
J Mol Cell Cardiol 50:43-9 (2011)
DOI:10.1016/j.yjmcc.2010.08.021
Related
pathway
hmh04010  MAPK signaling pathway
hmh04070  Phosphatidylinositol signaling system
hmh04210  Apoptosis
hmh04720  Long-term potentiation
hmh04730  Long-term depression
KO pathway
ko04020   

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