Fc epsilon RI signaling pathway - Homo sapiens (human)
Fc epsilon RI-mediated signaling pathways in mast cells are initiated by the interaction of antigen (Ag) with IgE bound to the extracellular domain of the alpha chain of Fc epsilon RI. The activation pathways are regulated both positively and negatively by the interactions of numerous signaling molecules. Mast cells that are thus activated release preformed granules which contain biogenic amines (especially histamines) and proteoglycans (especially heparin). The activation of phospholipase A2 causes the release of membrane lipids followed by development of lipid mediators such as leukotrienes (LTC4, LTD4 and LTE4) and prostaglandins (especially PDG2). There is also secretion of cytokines, the most important of which are TNF-alpha, IL-4 and IL-5. These mediators and cytokines contribute to inflammatory responses.
Organismal Systems; Immune system
hsa04664 Fc epsilon RI signaling pathway Ortholog table
D03095 Benzylpenicilloyl polylysine (USP)
D05671 Quiflapon sodium (USAN)
D10122 Fiboflapon sodium (USAN)
D11070 Tirabrutinib hydrochloride (JAN)
D11276 Rosiptor acetate (USAN)
D11873 Rilzabrutinib (USAN/INN)
D12158 Elsubrutinib (USAN/INN)
D12160 Orelabrutinib (USAN/INN)
D12285 Remibrutinib (USAN/INN)
Homo sapiens (human) [GN:
2206 MS4A2; membrane spanning 4-domains A2 [KO: K08090]
5290 PIK3CA; phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit alpha [KO: K00922] [EC: 220.127.116.11]
5293 PIK3CD; phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit delta [KO: K00922] [EC: 18.104.22.168]
5291 PIK3CB; phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit beta [KO: K00922] [EC: 22.214.171.124]
5295 PIK3R1; phosphoinositide-3-kinase regulatory subunit 1 [KO: K02649]
5296 PIK3R2; phosphoinositide-3-kinase regulatory subunit 2 [KO: K02649]
8503 PIK3R3; phosphoinositide-3-kinase regulatory subunit 3 [KO: K02649]
1437 CSF2; colony stimulating factor 2 [KO: K05427]
3937 LCP2; lymphocyte cytosolic protein 2 [KO: K07361]
10451 VAV3; vav guanine nucleotide exchange factor 3 [KO: K05730]
7409 VAV1; vav guanine nucleotide exchange factor 1 [KO: K05730]
7410 VAV2; vav guanine nucleotide exchange factor 2 [KO: K05730]
9846 GAB2; GRB2 associated binding protein 2 [KO: K08091]
27040 LAT; linker for activation of T cells [KO: K07362]
2885 GRB2; growth factor receptor bound protein 2 [KO: K04364]
6654 SOS1; SOS Ras/Rac guanine nucleotide exchange factor 1 [KO: K03099]
6655 SOS2; SOS Ras/Rho guanine nucleotide exchange factor 2 [KO: K03099]
3265 HRAS; HRas proto-oncogene, GTPase [KO: K02833]
3845 KRAS; KRAS proto-oncogene, GTPase [KO: K07827]
4893 NRAS; NRAS proto-oncogene, GTPase [KO: K07828]
241 ALOX5AP; arachidonate 5-lipoxygenase activating protein [KO: K20735]
C01245 D-myo-Inositol 1,4,5-trisphosphate
Kawakami T, Galli SJ.
Regulation of mast-cell and basophil function and survival by IgE.
Mast cell signal transduction from the high-affinity IgE receptor.
Janeway CA, Travers P, Walport M, Shlomchik MJ.
Immunobiology 6th edition
Garland Science Publishing (2005)
Turner H, Kinet JP.
Signalling through the high-affinity IgE receptor Fc epsilonRI.
Gilfillan AM, Tkaczyk C.
Integrated signalling pathways for mast-cell activation.
Nadler MJ, Matthews SA, Turner H, Kinet JP.
Signal transduction by the high-affinity immunoglobulin E receptor Fc epsilon RI: coupling form to function.
Gu H, Saito K, Klaman LD, Shen J, Fleming T, Wang Y, Pratt JC, Lin G, Lim B, Kinet JP, Neel BG.
Essential role for Gab2 in the allergic response.
Nadler MJ, Kinet JP.
Uncovering new complexities in mast cell signaling.
hsa04070 Phosphatidylinositol signaling system
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