Entry
Name
Cytokine-cytokine receptor interaction - Loxodonta africana (African savanna elephant)
Description
Cytokines are soluble extracellular proteins or glycoproteins that are crucial intercellular regulators and mobilizers of cells engaged in innate as well as adaptive inflammatory host defenses, cell growth, differentiation, cell death, angiogenesis, and development and repair processes aimed at the restoration of homeostasis. Cytokines are released by various cells in the body, usually in response to an activating stimulus, and they induce responses through binding to specific receptors on the cell surface of target cells. Cytokines can be grouped by structure into different families and their receptors can likewise be grouped.
Class
Environmental Information Processing; Signaling molecules and interaction
BRITE hierarchy
Pathway map
lav04060 Cytokine-cytokine receptor interaction
Organism
Loxodonta africana (African savanna elephant) [GN:
lav ]
Gene
100653529 GDF11; LOW QUALITY PROTEIN: growth/differentiation factor 11 [KO:K22679 ]
100654327 TNFSF13B; tumor necrosis factor ligand superfamily member 13B [KO:K05476 ]
100655062 TNFRSF11B; tumor necrosis factor receptor superfamily member 11B [KO:K05148 ]
100655626 TNFSF8; tumor necrosis factor ligand superfamily member 8 [KO:K05471 ]
100655653 EDAR; tumor necrosis factor receptor superfamily member EDAR [KO:K05162 ]
100655906 IL11RA; LOW QUALITY PROTEIN: interleukin-11 receptor subunit alpha [KO:K05056 ]
100655908 TNFSF15; tumor necrosis factor ligand superfamily member 15 [KO:K05478 ]
100657655 CSF3; granulocyte colony-stimulating factor isoform X6 [KO:K05423 ]
100657715 FAS; tumor necrosis factor receptor superfamily member 6 isoform X1 [KO:K04390 ]
100658408 IL18RAP; interleukin-18 receptor accessory protein isoform X1 [KO:K05174 ]
100658560 LIFR; LOW QUALITY PROTEIN: leukemia inhibitory factor receptor [KO:K05058 ]
100659733 TNFSF10; tumor necrosis factor ligand superfamily member 10 isoform X1 [KO:K04721 ]
100659923 TNFRSF4; tumor necrosis factor receptor superfamily member 4 [KO:K05142 ]
100660007 TNFRSF8; tumor necrosis factor receptor superfamily member 8 [KO:K05145 ]
100660206 TNFRSF18; tumor necrosis factor receptor superfamily member 18 isoform X1 [KO:K05154 ]
100661208 TNFSF9; tumor necrosis factor ligand superfamily member 9 [KO:K05472 ]
100661365 IL13RA1; interleukin-13 receptor subunit alpha-1 isoform X1 [KO:K05076 ]
100661891 TNFRSF11A; tumor necrosis factor receptor superfamily member 11A [KO:K05147 ]
100662052 RELT; tumor necrosis factor receptor superfamily member 19L isoform X3 [KO:K05156 ]
100662131 TNFRSF17; tumor necrosis factor receptor superfamily member 17 [KO:K05153 ]
100662586 FASLG; tumor necrosis factor ligand superfamily member 6 [KO:K04389 ]
100663523 TNFSF11; tumor necrosis factor ligand superfamily member 11 [KO:K05473 ]
100664139 CSF2RA; granulocyte-macrophage colony-stimulating factor receptor subunit alpha isoform X1 [KO:K05066 ]
100664834 IL2RG; cytokine receptor common subunit gamma isoform X1 [KO:K05070 ]
100665125 TNFRSF9; tumor necrosis factor receptor superfamily member 9 isoform X4 [KO:K05146 ]
100665401 GDF7; LOW QUALITY PROTEIN: growth/differentiation factor 7 [KO:K20013 ]
100665706 CSF3R; LOW QUALITY PROTEIN: granulocyte colony-stimulating factor receptor [KO:K05061 ]
100666176 IL12RB2; interleukin-12 receptor subunit beta-2 isoform X1 [KO:K05064 ]
100666178 CD40; tumor necrosis factor receptor superfamily member 5 [KO:K03160 ]
100666654 IL1RAP; interleukin-1 receptor accessory protein isoform X2 [KO:K04723 ]
100667054 TNFRSF12A; tumor necrosis factor receptor superfamily member 12A isoform X2 [KO:K05149 ]
100667317 GDF1; LOW QUALITY PROTEIN: embryonic growth/differentiation factor 1 [KO:K05495 ]
100667872 IL10RB; interleukin-10 receptor subunit beta isoform X2 [KO:K05135 ]
100669139 IL2RB; interleukin-2 receptor subunit beta isoform X1 [KO:K05069 ]
100669282 TNFSF4; tumor necrosis factor ligand superfamily member 4 [KO:K05469 ]
100669556 IL6ST; interleukin-6 receptor subunit beta isoform X2 [KO:K05060 ]
100670665 TNFRSF6B; LOW QUALITY PROTEIN: tumor necrosis factor receptor superfamily member 6B [KO:K05143 ]
100670704 CSF1; macrophage colony-stimulating factor 1 isoform X3 [KO:K05453 ]
100670763 TSLP; LOW QUALITY PROTEIN: thymic stromal lymphopoietin [KO:K05436 ]
100671102 NGFR; LOW QUALITY PROTEIN: tumor necrosis factor receptor superfamily member 16 [KO:K02583 ]
100671266 IL7R; interleukin-7 receptor subunit alpha isoform X1 [KO:K05072 ]
100671599 CLCF1; LOW QUALITY PROTEIN: cardiotrophin-like cytokine factor 1 [KO:K05421 ]
100672143 TNFRSF1A; LOW QUALITY PROTEIN: tumor necrosis factor receptor superfamily member 1A [KO:K03158 ]
100672530 EDA2R; LOW QUALITY PROTEIN: tumor necrosis factor receptor superfamily member 27 [KO:K05163 ]
100672715 LTBR; tumor necrosis factor receptor superfamily member 3 [KO:K03159 ]
100672726 IL12RB1; interleukin-12 receptor subunit beta-1 isoform X1 [KO:K05063 ]
100672839 BMP6; LOW QUALITY PROTEIN: bone morphogenetic protein 6 [KO:K16620 ]
100673654 CNTFR; ciliary neurotrophic factor receptor subunit alpha [KO:K05059 ]
100673830 TNFSF14; tumor necrosis factor ligand superfamily member 14 isoform X1 [KO:K05477 ]
100674816 TNFRSF14; tumor necrosis factor receptor superfamily member 14 isoform X1 [KO:K05152 ]
100674920 TNFRSF19; tumor necrosis factor receptor superfamily member 19 [KO:K05155 ]
100675007 CD4; LOW QUALITY PROTEIN: T-cell surface glycoprotein CD4 [KO:K06454 ]
100675335 CSF2; granulocyte-macrophage colony-stimulating factor [KO:K05427 ]
100675615 TNFRSF21; tumor necrosis factor receptor superfamily member 21 [KO:K05157 ]
100676177 TNFRSF13B; tumor necrosis factor receptor superfamily member 13B [KO:K05150 ]
104845437 TNFSF13; LOW QUALITY PROTEIN: tumor necrosis factor ligand superfamily member 13 [KO:K05475 ]
104847204 IL3RA; interleukin-3 receptor subunit alpha isoform X1 [KO:K04737 ]
Reference
Authors
Turner MD, Nedjai B, Hurst T, Pennington DJ
Title
Cytokines and chemokines: At the crossroads of cell signalling and inflammatory disease.
Journal
Reference
Authors
Brocker C, Thompson D, Matsumoto A, Nebert DW, Vasiliou V
Title
Evolutionary divergence and functions of the human interleukin (IL) gene family.
Journal
Reference
Authors
Akdis M, Aab A, Altunbulakli C, Azkur K, Costa RA, Crameri R, Duan S, Eiwegger T, Eljaszewicz A, Ferstl R, Frei R, Garbani M, Globinska A, Hess L, Huitema C, Kubo T, Komlosi Z, Konieczna P, Kovacs N, Kucuksezer UC, Meyer N, Morita H, Olzhausen J, O'Mahony L, Pezer M, Prati M, Rebane A, Rhyner C, Rinaldi A, Sokolowska M, Stanic B, Sugita K, Treis A, van de Veen W, Wanke K, Wawrzyniak M, Wawrzyniak P, Wirz OF, Zakzuk JS, Akdis CA
Title
Interleukins (from IL-1 to IL-38), interferons, transforming growth factor beta, and TNF-alpha: Receptors, functions, and roles in diseases.
Journal
Reference
Authors
Boulanger MJ, Garcia KC
Title
Shared cytokine signaling receptors: structural insights from the gp130 system.
Journal
Reference
Authors
Allan SM, Tyrrell PJ, Rothwell NJ
Title
Interleukin-1 and neuronal injury.
Journal
Reference
Authors
Lopetuso LR, Chowdhry S, Pizarro TT
Title
Opposing Functions of Classic and Novel IL-1 Family Members in Gut Health and Disease.
Journal
Reference
Authors
Iwakura Y, Ishigame H, Saijo S, Nakae S
Title
Functional specialization of interleukin-17 family members.
Journal
Reference
Authors
Fischer P, Hilfiker-Kleiner D
Title
Survival pathways in hypertrophy and heart failure: the gp130-STAT3 axis.
Journal
Reference
Authors
Richards CD
Title
The enigmatic cytokine oncostatin m and roles in disease.
Journal
Reference
Authors
Zhang Q, Putheti P, Zhou Q, Liu Q, Gao W
Title
Structures and biological functions of IL-31 and IL-31 receptors.
Journal
Reference
Authors
Meenhuis A, Verwijmeren C, Roovers O, Touw IP
Title
The deubiquitinating enzyme DUB2A enhances CSF3 signalling by attenuating lysosomal routing of the CSF3 receptor.
Journal
Reference
Authors
de Weerd NA, Nguyen T
Title
The interferons and their receptors--distribution and regulation.
Journal
Reference
Authors
Aggarwal BB
Title
Signalling pathways of the TNF superfamily: a double-edged sword.
Journal
Reference
Authors
Ashkenazi A
Title
Targeting death and decoy receptors of the tumour-necrosis factor superfamily.
Journal
Reference
Authors
Seeger P, Musso T, Sozzani S
Title
The TGF-beta superfamily in dendritic cell biology.
Journal
Reference
Authors
Wakefield LM, Hill CS
Title
Beyond TGFbeta: roles of other TGFbeta superfamily members in cancer.
Journal
Reference
Authors
Mueller TD, Nickel J
Title
Promiscuity and specificity in BMP receptor activation.
Journal
KO pathway