KEGG   PATHWAY: mun04020
Entry
mun04020                    Pathway                                
Name
Calcium signaling pathway - Meriones unguiculatus (Mongolian gerbil)
Description
Ca2+ that enters the cell from the outside is a principal source of signal Ca2+. Entry of Ca2+ is driven by the presence of a large electrochemical gradient across the plasma membrane. Cells use this external source of signal Ca2+ by activating various entry channels with widely different properties. The voltage-operated channels (VOCs) are found in excitable cells and generate the rapid Ca2+ fluxes that control fast cellular processes. There are many other Ca2+-entry channels, such as the receptor-operated channels (ROCs), for example the NMDA (N-methyl-D-aspartate) receptors (NMDARs) that respond to glutamate. There also are second-messenger-operated channels (SMOCs) and store-operated channels (SOCs).
The other principal source of Ca2+ for signalling is the internal stores that are located primarily in the endoplasmic/sarcoplasmic reticulum (ER/SR), in which inositol-1,4,5-trisphosphate receptors (IP3Rs) or ryanodine receptors (RYRs) regulate the release of Ca2+. The principal activator of these channels is Ca2+ itself and this process of Ca2+-induced Ca2+ release is central to the mechanism of Ca2+ signalling. Various second messengers or modulators also control the release of Ca2+. IP3, which is generated by pathways using different isoforms of phospholipase C (PLCbeta, delta, epsilon, gamma and zeta), regulates the IP3Rs. Cyclic ADP-ribose (cADPR) releases Ca2+ via RYRs. Nicotinic acid adenine dinucleotide phosphate (NAADP) may activate a distinct Ca2+ release mechanism on separate acidic Ca2+ stores. Ca2+ release via the NAADP-sensitive mechanism may also feedback onto either RYRs or IP3Rs. cADPR and NAADP are generated by CD38. This enzyme might be sensitive to the cellular metabolism, as ATP and NADH inhibit it.
The influx of Ca2+ from the environment or release from internal stores causes a very rapid and dramatic increase in cytoplasmic calcium concentration, which has been widely exploited for signal transduction. Some proteins, such as troponin C (TnC) involved in muscle contraction, directly bind to and sense Ca2+. However, in other cases Ca2+ is sensed through intermediate calcium sensors such as calmodulin (CALM).
Class
Environmental Information Processing; Signal transduction
Pathway map
mun04020  Calcium signaling pathway
mun04020

Other DBs
GO: 0019722
Organism
Meriones unguiculatus (Mongolian gerbil) [GN:mun]
Gene
110539346  Gna14; guanine nucleotide-binding protein subunit alpha-14 isoform X1 [KO:K04636]
110539373  [KO:K04166]
110539385  Vegfd; vascular endothelial growth factor D isoform X3 [KO:K05449]
110539533  Fgf16; fibroblast growth factor 16 [KO:K04358]
110539539  Egfr; epidermal growth factor receptor [KO:K04361] [EC:2.7.10.1]
110539846  Grm5; metabotropic glutamate receptor 5 isoform X1 [KO:K04604]
110540260  Pdgfd; platelet-derived growth factor D isoform X1 [KO:K05450]
110540510  Trhr; thyrotropin-releasing hormone receptor isoform X1 [KO:K04282]
110540777  Erbb4; receptor tyrosine-protein kinase erbB-4 isoform X1 [KO:K05085] [EC:2.7.10.1]
110541273  Cacna1c; voltage-dependent L-type calcium channel subunit alpha-1C isoform X1 [KO:K04850]
110541678  Phka2; phosphorylase b kinase regulatory subunit alpha, liver isoform isoform X1 [KO:K07190]
110541849  Grpr; gastrin-releasing peptide receptor [KO:K04169]
110542126  Vegfc; vascular endothelial growth factor C [KO:K05449]
110542507  Pdgfc; platelet-derived growth factor C isoform X1 [KO:K05450]
110542683  Htr2c; 5-hydroxytryptamine receptor 2C isoform X1 [KO:K04157]
110542928  [KO:K07190]
110543028  Ednrb; endothelin receptor type B isoform X1 [KO:K04198]
110543748  Itpr3; inositol 1,4,5-trisphosphate receptor type 3 [KO:K04960]
110543951  Nfatc4; nuclear factor of activated T-cells, cytoplasmic 4 isoform X1 [KO:K17334]
110544265  Tacr3; neuromedin-K receptor [KO:K04224]
110544977  Htr6; 5-hydroxytryptamine receptor 6 [KO:K04162]
110545114  Adrb1; beta-1 adrenergic receptor [KO:K04141]
110545207  [KO:K04282]
110545270  Htr7; 5-hydroxytryptamine receptor 7 isoform X2 [KO:K04163]
110545302  [KO:K16056]
110545322  Atp2a2; sarcoplasmic/endoplasmic reticulum calcium ATPase 2 [KO:K05853] [EC:7.2.2.10]
110545323  P2rx4; P2X purinoceptor 4 isoform X2 [KO:K05218]
110545350  P2rx7; P2X purinoceptor 7 isoform X1 [KO:K05220]
110545647  Plcd3; 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase delta-3 isoform X1 [KO:K05857] [EC:3.1.4.11]
110545836  Cacna1a; voltage-dependent P/Q-type calcium channel subunit alpha-1A isoform X1 [KO:K04344]
110545842  Prkaca; cAMP-dependent protein kinase catalytic subunit alpha isoform X1 [KO:K04345] [EC:2.7.11.11]
110545849  Ptger1; prostaglandin E2 receptor EP1 subtype [KO:K04258]
110545886  Fgf2; fibroblast growth factor 2 [KO:K18497]
110545902  Nfatc3; nuclear factor of activated T-cells, cytoplasmic 3 isoform X1 [KO:K17333]
110545944  Adcy9; adenylate cyclase type 9 isoform X1 [KO:K08049] [EC:4.6.1.1]
110546095  Camk2b; calcium/calmodulin-dependent protein kinase type II subunit beta isoform X8 [KO:K04515] [EC:2.7.11.17]
110546382  Tpcn1; two pore channel protein 1 isoform X1 [KO:K16896]
110546441  Fgf3; fibroblast growth factor 3 [KO:K04358]
110546517  Fgf19; fibroblast growth factor 19 [KO:K22603]
110546548  Fgf4; fibroblast growth factor 4 [KO:K04358]
110546686  Camk2a; calcium/calmodulin-dependent protein kinase type II subunit alpha isoform X3 [KO:K04515] [EC:2.7.11.17]
110546695  Pdgfrb; platelet-derived growth factor receptor beta [KO:K05089] [EC:2.7.10.1]
110546737  Atp2b4; plasma membrane calcium-transporting ATPase 4 isoform X1 [KO:K05850] [EC:7.2.2.10]
110546949  Tpcn2; two pore channel protein 2 isoform X1 [KO:K14077]
110547163  Tgfa; protransforming growth factor alpha [KO:K08774]
110547228  Mylk; myosin light chain kinase, smooth muscle isoform X1 [KO:K00907] [EC:2.7.11.18]
110547352  Nfatc2; nuclear factor of activated T-cells, cytoplasmic 2 isoform X1 [KO:K17332]
110547372  Flt4; vascular endothelial growth factor receptor 3 isoform X1 [KO:K05097] [EC:2.7.10.1]
110547567  Cacna1d; voltage-dependent L-type calcium channel subunit alpha-1D isoform X1 [KO:K04851]
110547593  Tnnc1; troponin C, slow skeletal and cardiac muscles [KO:K05865]
110547611  Grin2c; glutamate receptor ionotropic, NMDA 2C isoform X1 [KO:K05211]
110547817  Fgf18; fibroblast growth factor 18 [KO:K04358]
110547949  Atp2a1; sarcoplasmic/endoplasmic reticulum calcium ATPase 1 isoform X1 [KO:K05853] [EC:7.2.2.10]
110547989  Phkg2; phosphorylase b kinase gamma catalytic chain, liver/testis isoform isoform X1 [KO:K00871] [EC:2.7.11.19]
110548322  Oxtr; oxytocin receptor [KO:K04229]
110548425  Cacna1s; LOW QUALITY PROTEIN: voltage-dependent L-type calcium channel subunit alpha-1S [KO:K04857]
110548505  Gna15; guanine nucleotide-binding protein subunit alpha-15 isoform X1 [KO:K04637]
110548534  Gna11; guanine nucleotide-binding protein subunit alpha-11 [KO:K04635]
110548537  Tbxa2r; thromboxane A2 receptor [KO:K04264]
110548616  Fgf6; fibroblast growth factor 6 [KO:K04358]
110548635  Fgf23; fibroblast growth factor 23 [KO:K22428]
110548671  Cacna1h; voltage-dependent T-type calcium channel subunit alpha-1H [KO:K04855]
110548867  Vdac2; voltage-dependent anion-selective channel protein 2 [KO:K15040]
110548917  Hrh1; histamine H1 receptor [KO:K04149]
110548926  Camk1; calcium/calmodulin-dependent protein kinase type 1 isoform X1 [KO:K08794] [EC:2.7.11.17]
110548952  Atp2b2; plasma membrane calcium-transporting ATPase 2 isoform X4 [KO:K05850] [EC:7.2.2.10]
110549391  Tnnc2; troponin C, skeletal muscle isoform X1 [KO:K12042]
110549485  Sln; sarcolipin [KO:K22642]
110549632  Vdac1; voltage-dependent anion-selective channel protein 1 [KO:K05862]
110549737  Fgf9; fibroblast growth factor 9 [KO:K04358]
110549775  Fgfr4; fibroblast growth factor receptor 4 [KO:K05095] [EC:2.7.10.1]
110549785  Adora2b; adenosine receptor A2b [KO:K04267]
110550095  Mylk2; myosin light chain kinase 2, skeletal/cardiac muscle [KO:K00907] [EC:2.7.11.18]
110550157  Nos2; nitric oxide synthase, inducible isoform X1 [KO:K13241] [EC:1.14.13.39]
110550203  Adrb3; beta-3 adrenergic receptor [KO:K04143]
110550243  Tfeb; transcription factor EB isoform X1 [KO:K15590]
110550263  Plcg2; 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-2 [KO:K05859] [EC:3.1.4.11]
110550273  Nfatc1; nuclear factor of activated T-cells, cytoplasmic 1 isoform X1 [KO:K04446]
110550304  Avpr1b; vasopressin V1b receptor [KO:K04227]
110550366  Vegfa; vascular endothelial growth factor A, long form isoform X3 [KO:K05448]
110550427  Cacna1i; LOW QUALITY PROTEIN: voltage-dependent T-type calcium channel subunit alpha-1I [KO:K04856]
110550451  Fgf10; fibroblast growth factor 10 [KO:K04358]
110550476  Grin2d; glutamate receptor ionotropic, NMDA 2D isoform X1 [KO:K05212]
110550495  Sphk2; sphingosine kinase 2 isoform X1 [KO:K04718] [EC:2.7.1.91]
110550501  Fgf21; fibroblast growth factor 21 [KO:K22429]
110550525  Fgf5; fibroblast growth factor 5 isoform X1 [KO:K04358]
110550527  Calml4; calmodulin-like protein 4 isoform X1 [KO:K02183]
110550596  Itpka; inositol-trisphosphate 3-kinase A [KO:K00911] [EC:2.7.1.127]
110550598  Plcb2; 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-2 isoform X1 [KO:K05858] [EC:3.1.4.11]
110550699  Pdgfa; platelet-derived growth factor subunit A isoform X3 [KO:K04359]
110550962  Adcy2; adenylate cyclase type 2 isoform X1 [KO:K08042] [EC:4.6.1.1]
110551097  F2r; proteinase-activated receptor 1 [KO:K03914]
110551099  Ednra; endothelin-1 receptor [KO:K04197]
110551337  Grin3b; glutamate receptor ionotropic, NMDA 3B [KO:K05214]
110551350  Fgf22; fibroblast growth factor 22 isoform X1 [KO:K04358]
110551449  Chrm3; muscarinic acetylcholine receptor M3 [KO:K04131]
110551595  Plcb3; 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-3 [KO:K05858] [EC:3.1.4.11]
110551598  Vegfb; vascular endothelial growth factor B isoform X1 [KO:K16858]
110551668  Ppp3cc; serine/threonine-protein phosphatase 2B catalytic subunit gamma isoform isoform X2 [KO:K04348] [EC:3.1.3.16]
110551884  Nos1; nitric oxide synthase 1 [KO:K13240] [EC:1.14.13.39]
110551961  P2rx3; P2X purinoceptor 3 [KO:K05217]
110551992  Ppp3cb; serine/threonine-protein phosphatase 2B catalytic subunit beta isoform isoform X4 [KO:K04348] [EC:3.1.3.16]
110551996  Camk2g; calcium/calmodulin-dependent protein kinase type II subunit gamma isoform X2 [KO:K04515] [EC:2.7.11.17]
110552065  Cacna1g; voltage-dependent T-type calcium channel subunit alpha-1G isoform X1 [KO:K04854]
110552126  Atp2b1; plasma membrane calcium-transporting ATPase 1 isoform X1 [KO:K05850] [EC:7.2.2.10]
110552142  Itpr1; inositol 1,4,5-trisphosphate receptor type 1 [KO:K04958]
110552362  Camk1d; calcium/calmodulin-dependent protein kinase type 1D isoform X1 [KO:K08794] [EC:2.7.11.17]
110552446  Ntrk3; NT-3 growth factor receptor isoform X4 [KO:K05101] [EC:2.7.10.1]
110552535  Ryr1; ryanodine receptor 1 [KO:K04961]
110552646  Calm3; calmodulin-3 [KO:K02183]
110552764  Cckar; cholecystokinin receptor type A [KO:K04194]
110552794  Plcg1; 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1 isoform X1 [KO:K01116] [EC:3.1.4.11]
110552899  Lhcgr; lutropin-choriogonadotropic hormone receptor [KO:K04248]
110552995  Mylk3; myosin light chain kinase 3 isoform X1 [KO:K00907] [EC:2.7.11.18]
110552996  Phkb; phosphorylase b kinase regulatory subunit beta isoform X1 [KO:K07190]
110553168  P2rx2; P2X purinoceptor 2 isoform X8 [KO:K05216]
110553196  Egf; pro-epidermal growth factor [KO:K04357]
110553595  Cysltr2; cysteinyl leukotriene receptor 2 [KO:K04323]
110553862  Adora2a; adenosine receptor A2a [KO:K04266]
110554059  Drd1; D(1A) dopamine receptor [KO:K04144]
110554064  Hrh2; histamine H2 receptor [KO:K04150]
110554410  Htr2a; 5-hydroxytryptamine receptor 2A [KO:K04157]
110554671  Pde1c; dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1C isoform X1 [KO:K13755] [EC:3.1.4.17]
110554917  Ntsr1; neurotensin receptor type 1 [KO:K04211]
110554946  Fgfr2; fibroblast growth factor receptor 2 isoform X3 [KO:K05093] [EC:2.7.10.1]
110555016  Prkacb; cAMP-dependent protein kinase catalytic subunit beta isoform X1 [KO:K04345] [EC:2.7.11.11]
110555042  Plcd1; 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase delta-1 isoform X2 [KO:K05857] [EC:3.1.4.11]
110555169  Adcy1; adenylate cyclase type 1 [KO:K08041] [EC:4.6.1.1]
110555185  Adcy3; adenylate cyclase type 3 isoform X3 [KO:K08043] [EC:4.6.1.1]
110555211  Slc8a2; sodium/calcium exchanger 2 isoform X1 [KO:K05849]
110555335  Prkca; protein kinase C alpha type [KO:K02677] [EC:2.7.11.13]
110555363  Htr5a; 5-hydroxytryptamine receptor 5A [KO:K04161]
110555409  Cxcr4; C-X-C chemokine receptor type 4 [KO:K04189]
110555434  Plcz1; 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase zeta-1 [KO:K05861] [EC:3.1.4.11]
110555459  Adra1b; alpha-1B adrenergic receptor isoform X1 [KO:K04136]
110555487  Chrm5; muscarinic acetylcholine receptor M5 [KO:K04133]
110555488  Ryr3; ryanodine receptor 3 [KO:K04963]
110555720  Plcb1; 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-1 isoform X1 [KO:K05858] [EC:3.1.4.11]
110555920  Bdkrb2; B2 bradykinin receptor isoform X1 [KO:K03916]
110555926  Bdkrb1; B1 bradykinin receptor [KO:K03915]
110555973  Ppp3ca; protein phosphatase 3 catalytic subunit alpha isoform X1 [KO:K04348] [EC:3.1.3.16]
110556016  Prkcg; protein kinase C gamma type [KO:K19663] [EC:2.7.11.13]
110556120  Htr2b; 5-hydroxytryptamine receptor 2B [KO:K04157]
110556521  Adcy4; adenylate cyclase type 4 isoform X1 [KO:K08044] [EC:4.6.1.1]
110556531  Ltb4r2; leukotriene B4 receptor 2 [KO:K04297]
110556618  Vdac3; voltage-dependent anion-selective channel protein 3 [KO:K15041]
110556711  Casq1; calsequestrin-1 [KO:K23468]
110556739  Itpkc; inositol-trisphosphate 3-kinase C isoform X1 [KO:K00911] [EC:2.7.1.127]
110556776  Fgf8; fibroblast growth factor 8 isoform X4 [KO:K04358]
110556812  Slc25a4; ADP/ATP translocase 1 [KO:K05863]
110556866  Stim2; stromal interaction molecule 2 [KO:K18196]
110556944  Kdr; vascular endothelial growth factor receptor 2 [KO:K05098] [EC:2.7.10.1]
110556997  Grin1; glutamate receptor ionotropic, NMDA 1 isoform X1 [KO:K05208]
110557138  Adra1d; alpha-1D adrenergic receptor [KO:K04137]
110557186  Ptafr; platelet-activating factor receptor [KO:K04279]
110557236  Orai2; protein orai-2 isoform X2 [KO:K16057]
110557305  Fgfr3; fibroblast growth factor receptor 3 isoform X1 [KO:K05094] [EC:2.7.10.1]
110557477  Chrm1; muscarinic acetylcholine receptor M1 [KO:K04129]
110557538  Pln; cardiac phospholamban [KO:K05852]
110557547  Stim1; stromal interaction molecule 1 isoform X3 [KO:K16059]
110557591  Pde1b; dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1B isoform X1 [KO:K13755] [EC:3.1.4.17]
110557819  Pdgfb; platelet-derived growth factor subunit B isoform X1 [KO:K17386]
110557978  Chrm2; muscarinic acetylcholine receptor M2 [KO:K04130]
110557989  Mcu; calcium uniporter protein, mitochondrial isoform X1 [KO:K20858]
110558019  Ret; proto-oncogene tyrosine-protein kinase receptor Ret [KO:K05126] [EC:2.7.10.1]
110558105  Pdgfra; platelet-derived growth factor receptor alpha [KO:K04363] [EC:2.7.10.1]
110558303  Mcoln2; mucolipin-2 isoform X1 [KO:K04993]
110558305  Mcoln3; mucolipin-3 isoform X1 [KO:K04994]
110558635  Mylk4; myosin light chain kinase family member 4 [KO:K00907] [EC:2.7.11.18]
110558703  Met; hepatocyte growth factor receptor [KO:K05099] [EC:2.7.10.1]
110558908  Itpr2; inositol 1,4,5-trisphosphate receptor type 2 isoform X1 [KO:K04959]
110558957  Ppp3r1; calcineurin subunit B type 1 [KO:K06268]
110559148  Cd38; ADP-ribosyl cyclase/cyclic ADP-ribose hydrolase 1 [KO:K01242] [EC:3.2.2.6 2.4.99.20]
110559219  P2rx6; P2X purinoceptor 6 isoform X2 [KO:K05221]
110559230  Ptk2b; protein-tyrosine kinase 2-beta isoform X1 [KO:K05871] [EC:2.7.10.2]
110559262  Atp2a3; sarcoplasmic/endoplasmic reticulum calcium ATPase 3 [KO:K05853] [EC:7.2.2.10]
110559275  P2rx5; P2X purinoceptor 5 [KO:K05219]
110559276  P2rx1; P2X purinoceptor 1 isoform X1 [KO:K05215]
110559286  Fgf1; fibroblast growth factor 1 isoform X1 [KO:K18496]
110559305  Adra1a; alpha-1A adrenergic receptor [KO:K04135]
110559383  Erbb3; receptor tyrosine-protein kinase erbB-3 [KO:K05084] [EC:2.7.10.1]
110559483  Itpkb; inositol-trisphosphate 3-kinase B isoform X1 [KO:K00911] [EC:2.7.1.127]
110559612  Prkcb; protein kinase C beta type isoform X1 [KO:K19662] [EC:2.7.11.13]
110559791  Orai3; protein orai-3 isoform X1 [KO:K16058]
110559814  Camk1g; calcium/calmodulin-dependent protein kinase type 1G isoform X1 [KO:K08794] [EC:2.7.11.17]
110559942  Slc8a1; sodium/calcium exchanger 1 isoform X6 [KO:K05849]
110559959  Tacr1; substance-P receptor [KO:K04222]
110560157  Fgf7; fibroblast growth factor 7 isoform X1 [KO:K04358]
110560453  Atp2b3; plasma membrane calcium-transporting ATPase 3 isoform X1 [KO:K05850] [EC:7.2.2.10]
110560635  Hrc; sarcoplasmic reticulum histidine-rich calcium-binding protein [KO:K23450]
110560701  Calml3; calmodulin-like protein 3 [KO:K02183]
110560702  [KO:K02183]
110560723  Adcy7; adenylate cyclase type 7 isoform X1 [KO:K08047] [EC:4.6.1.1]
110560975  Phkg1; phosphorylase b kinase gamma catalytic chain, skeletal muscle/heart isoform isoform X1 [KO:K00871] [EC:2.7.11.19]
110561078  Casq2; calsequestrin-2 [KO:K23445]
110561324  Grin3a; glutamate receptor ionotropic, NMDA 3A isoform X1 [KO:K05213]
110561325  Ppp3r2; calcineurin subunit B type 2 [KO:K06268]
110561484  Calm1; calmodulin-1 [KO:K02183]
110561495  [KO:K04809]
110561693  Grin2a; glutamate receptor ionotropic, NMDA 2A [KO:K05209]
110561696  Adcy8; adenylate cyclase type 8 isoform X1 [KO:K08048] [EC:4.6.1.1]
110561910  Cacna1f; voltage-dependent L-type calcium channel subunit alpha-1F isoform X1 [KO:K04853]
110562030  Adrb2; beta-2 adrenergic receptor [KO:K04142]
110562031  Htr4; 5-hydroxytryptamine receptor 4 isoform X1 [KO:K04160]
110562438  Gnal; guanine nucleotide-binding protein G(olf) subunit alpha isoform X1 [KO:K04633]
110562511  Gnaq; guanine nucleotide-binding protein G(q) subunit alpha [KO:K04634]
110562552  Nos3; nitric oxide synthase 3 isoform X1 [KO:K13242] [EC:1.14.13.39]
110562902  Pde1a; dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A isoform X3 [KO:K13755] [EC:3.1.4.17]
110562911  Asph; aspartyl/asparaginyl beta-hydroxylase isoform X4 [KO:K00476] [EC:1.14.11.16]
110562918  Calm2; calmodulin-2 [KO:K02183]
110562952  Erbb2; receptor tyrosine-protein kinase erbB-2 [KO:K05083] [EC:2.7.10.1]
110562967  Slc8a3; sodium/calcium exchanger 3 isoform X1 [KO:K05849]
110563016  [KO:K26467]
110563019  Agtr1; type-1 angiotensin II receptor [KO:K04166]
110563057  Cacna1b; voltage-dependent N-type calcium channel subunit alpha-1B isoform X1 [KO:K04849]
110563120  [KO:K04161]
110563159  [KO:K05858] [EC:3.1.4.11]
110563236  Cacna1e; voltage-dependent R-type calcium channel subunit alpha-1E [KO:K04852]
110563307  Fgfr1; fibroblast growth factor receptor 1 isoform X1 [KO:K04362] [EC:2.7.10.1]
110563508  Ptger3; prostaglandin E2 receptor EP3 subtype [KO:K04260]
110563608  [KO:K04632]
110563781  Tacr2; substance-K receptor [KO:K04223]
110563857  C10H4orf3; uncharacterized protein C4orf3 homolog [KO:K26467]
110564137  Ryr2; ryanodine receptor 2 [KO:K04962]
110564316  Fgf20; fibroblast growth factor 20 [KO:K04358]
110564378  Ngf; beta-nerve growth factor [KO:K02582]
110564670  Sphk1; sphingosine kinase 1 isoform X5 [KO:K04718] [EC:2.7.1.91]
110564688  Gdnf; glial cell line-derived neurotrophic factor [KO:K05452]
110564828  Camk4; calcium/calmodulin-dependent protein kinase type IV [KO:K05869] [EC:2.7.11.17]
110564899  Ptgfr; prostaglandin F2-alpha receptor [KO:K04262]
110564912  Mst1r; macrophage-stimulating protein receptor isoform X1 [KO:K05100] [EC:2.7.10.1]
110564977  Ntrk1; high affinity nerve growth factor receptor isoform X1 [KO:K03176] [EC:2.7.10.1]
110565019  Mst1; hepatocyte growth factor-like protein isoform X3 [KO:K23441]
110565075  Ntrk2; BDNF/NT-3 growth factors receptor isoform X1 [KO:K04360] [EC:2.7.10.1]
110565312  Hgf; hepatocyte growth factor isoform X1 [KO:K05460]
110565488  Ppif; peptidyl-prolyl cis-trans isomerase F, mitochondrial isoform X2 [KO:K09565] [EC:5.2.1.8]
110565513  Camk2d; calcium/calmodulin-dependent protein kinase type II subunit delta isoform X1 [KO:K04515] [EC:2.7.11.17]
110566206  Grm1; metabotropic glutamate receptor 1 isoform X1 [KO:K04603]
110566283  Avpr1a; vasopressin V1a receptor [KO:K04226]
110566446  Slc25a5; ADP/ATP translocase 2 [KO:K05863]
110566524  Plce1; 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase epsilon-1 [KO:K05860] [EC:3.1.4.11]
110566603  Cckbr; gastrin/cholecystokinin type B receptor [KO:K04195]
110566641  Plcd4; 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase delta-4 isoform X1 [KO:K05857] [EC:3.1.4.11]
110566742  Cysltr1; cysteinyl leukotriene receptor 1 [KO:K04322]
110566972  Slc25a31; ADP/ATP translocase 4 [KO:K05863]
Compound
C00002  ATP
C00004  NADH
C00076  Calcium cation
C00165  Diacylglycerol
C00575  3',5'-Cyclic AMP
C01245  D-myo-Inositol 1,4,5-trisphosphate
C01330  Sodium cation
C06124  Sphingosine 1-phosphate
C11556  1-Phosphatidyl-1D-myo-inositol 3,5-bisphosphate
C13050  Cyclic ADP-ribose
C13051  Nicotinic acid adenine dinucleotide phosphate
Reference
PMID:12838335
  Authors
Berridge MJ, Bootman MD, Roderick HL.
  Title
Calcium signalling: dynamics, homeostasis and remodelling.
  Journal
Nat Rev Mol Cell Biol 4:517-29 (2003)
DOI:10.1038/nrm1155
Reference
PMID:11413485
  Authors
Berridge MJ, Lipp P, Bootman MD.
  Title
The versatility and universality of calcium signalling.
  Journal
Nat Rev Mol Cell Biol 1:11-21 (2000)
DOI:10.1038/35036035
Reference
PMID:15111104
  Authors
Wang MC, Dolphin A, Kitmitto A.
  Title
L-type voltage-gated calcium channels: understanding function through structure.
  Journal
FEBS Lett 564:245-50 (2004)
DOI:10.1016/S0014-5793(04)00253-4
Reference
PMID:11299192
  Authors
Ferrier GR, Howlett SE.
  Title
Cardiac excitation-contraction coupling: role of membrane potential in regulation of contraction.
  Journal
Am J Physiol Heart Circ Physiol 280:H1928-44 (2001)
DOI:10.1152/ajpheart.2001.280.5.H1928
Reference
PMID:11698232
  Authors
Keef KD, Hume JR, Zhong J.
  Title
Regulation of cardiac and smooth muscle Ca(2+) channels (Ca(V)1.2a,b) by protein kinases.
  Journal
Am J Physiol Cell Physiol 281:C1743-56 (2001)
DOI:10.1152/ajpcell.2001.281.6.C1743
Reference
PMID:8125957
  Authors
Hell JW, Appleyard SM, Yokoyama CT, Warner C, Catterall WA.
  Title
Differential phosphorylation of two size forms of the N-type calcium channel alpha 1 subunit which have different COOH termini.
  Journal
J Biol Chem 269:7390-6 (1994)
Reference
PMID:15000521
  Authors
Yunker AM.
  Title
Modulation and pharmacology of low voltage-activated ("T-Type") calcium channels.
  Journal
J Bioenerg Biomembr 35:577-98 (2003)
DOI:10.1023/B:JOBB.0000008025.65675.37
Reference
PMID:9149541
  Authors
Yakel JL.
  Title
Calcineurin regulation of synaptic function: from ion channels to transmitter release and gene transcription.
  Journal
Trends Pharmacol Sci 18:124-34 (1997)
DOI:10.1016/S0165-6147(97)01046-8
Reference
PMID:10997573
  Authors
Fukunaga K, Miyamoto E.
  Title
A working model of CaM kinase II activity in hippocampal long-term potentiation and memory.
  Journal
Neurosci Res 38:3-17 (2000)
DOI:10.1016/S0168-0102(00)00139-5
Reference
PMID:9235901
  Authors
Della Rocca GJ, van Biesen T, Daaka Y, Luttrell DK, Luttrell LM, Lefkowitz RJ.
  Title
Ras-dependent mitogen-activated protein kinase activation by G protein-coupled receptors. Convergence of Gi- and Gq-mediated pathways on calcium/calmodulin, Pyk2, and Src kinase.
  Journal
J Biol Chem 272:19125-32 (1997)
DOI:10.1074/jbc.272.31.19125
Reference
PMID:7861177
  Authors
Furuichi T, Mikoshiba K.
  Title
Inositol 1, 4, 5-trisphosphate receptor-mediated Ca2+ signaling in the brain.
  Journal
J Neurochem 64:953-60 (1995)
DOI:10.1046/j.1471-4159.1995.64030953.x
Reference
PMID:14572802
  Authors
Bruce JI, Straub SV, Yule DI.
  Title
Crosstalk between cAMP and Ca2+ signaling in non-excitable cells.
  Journal
Cell Calcium 34:431-44 (2003)
DOI:10.1016/S0143-4160(03)00150-7
Reference
PMID:10331643
  Authors
Lee HC, Munshi C, Graeff R.
  Title
Structures and activities of cyclic ADP-ribose, NAADP and their metabolic enzymes.
  Journal
Mol Cell Biochem 193:89-98 (1999)
DOI:10.1007/978-1-4419-8740-2_13
Reference
PMID:11080247
  Authors
Crompton M.
  Title
Mitochondrial intermembrane junctional complexes and their role in cell death.
  Journal
J Physiol 529 Pt 1:11-21 (2000)
DOI:10.1111/j.1469-7793.2000.00011.x
Reference
PMID:10508738
  Authors
Grewal SS, York RD, Stork PJ.
  Title
Extracellular-signal-regulated kinase signalling in neurons.
  Journal
Curr Opin Neurobiol 9:544-53 (1999)
DOI:10.1016/S0959-4388(99)00010-0
Reference
PMID:12972622
  Authors
Trushin SA, Pennington KN, Carmona EM, Asin S, Savoy DN, Billadeau DD, Paya CV.
  Title
Protein kinase Calpha (PKCalpha) acts upstream of PKCtheta to activate IkappaB kinase and NF-kappaB in T lymphocytes.
  Journal
Mol Cell Biol 23:7068-81 (2003)
DOI:10.1128/MCB.23.19.7068-7081.2003
Reference
PMID:14517314
  Authors
Hutchins JR, Dikovskaya D, Clarke PR.
  Title
Regulation of Cdc2/cyclin B activation in Xenopus egg extracts via inhibitory phosphorylation of Cdc25C phosphatase by Ca(2+)/calmodulin-dependent protein [corrected] kinase II.
  Journal
Mol Biol Cell 14:4003-14 (2003)
DOI:10.1091/mbc.E03-02-0061
Reference
PMID:21338471
  Authors
Tornquist K
  Title
Sphingosine 1-phosphate, sphingosine kinase and autocrine calcium signalling in thyroid cells.
  Journal
Acta Physiol (Oxf) 204:151-7 (2012)
DOI:10.1111/j.1748-1716.2011.02265.x
Reference
PMID:22129055
  Authors
Feske S
  Title
Immunodeficiency due to defects in store-operated calcium entry.
  Journal
Ann N Y Acad Sci 1238:74-90 (2011)
DOI:10.1111/j.1749-6632.2011.06240.x
Reference
PMID:22002090
  Authors
Giachini FR, Lima VV, Hannan JL, Carneiro FS, Webb RC, Tostes RC
  Title
STIM1/Orai1-mediated store-operated Ca2+ entry: the tip of the iceberg.
  Journal
Braz J Med Biol Res 44:1080-7 (2011)
DOI:10.1590/S0100-879X2011007500133
Reference
PMID:19172794
  Authors
Baba Y, Kurosaki T
  Title
[Regulation of store-operated calcium entry by STIM1].
  Journal
Seikagaku 80:1123-8 (2008)
Reference
PMID:19475418
  Authors
Galione A, Evans AM, Ma J, Parrington J, Arredouani A, Cheng X, Zhu MX
  Title
The acid test: the discovery of two-pore channels (TPCs) as NAADP-gated endolysosomal Ca(2+) release channels.
  Journal
Pflugers Arch 458:869-76 (2009)
DOI:10.1007/s00424-009-0682-y
Reference
PMID:19434403
  Authors
Beard NA, Wei L, Dulhunty AF
  Title
Ca(2+) signaling in striated muscle: the elusive roles of triadin, junctin, and calsequestrin.
  Journal
Eur Biophys J 39:27-36 (2009)
DOI:10.1007/s00249-009-0449-6
Reference
PMID:26228554
  Authors
Marty I
  Title
Triadin regulation of the ryanodine receptor complex.
  Journal
J Physiol 593:3261-6 (2015)
DOI:10.1113/jphysiol.2014.281147
Reference
PMID:20807542
  Authors
Arvanitis DA, Vafiadaki E, Sanoudou D, Kranias EG
  Title
Histidine-rich calcium binding protein: the new regulator of sarcoplasmic reticulum calcium cycling.
  Journal
J Mol Cell Cardiol 50:43-9 (2011)
DOI:10.1016/j.yjmcc.2010.08.021
Related
pathway
mun04010  MAPK signaling pathway
mun04070  Phosphatidylinositol signaling system
mun04210  Apoptosis
mun04720  Long-term potentiation
mun04730  Long-term depression
KO pathway
ko04020   

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