KEGG   PATHWAY: oaa04060
Entry
oaa04060                    Pathway                                
Name
Cytokine-cytokine receptor interaction - Ornithorhynchus anatinus (platypus)
Description
Cytokines are soluble extracellular proteins or glycoproteins that are crucial intercellular regulators and mobilizers of cells engaged in innate as well as adaptive inflammatory host defenses, cell growth, differentiation, cell death, angiogenesis, and development and repair processes aimed at the restoration of homeostasis. Cytokines are released by various cells in the body, usually in response to an activating stimulus, and they induce responses through binding to specific receptors on the cell surface of target cells. Cytokines can be grouped by structure into different families and their receptors can likewise be grouped.
Class
Environmental Information Processing; Signaling molecules and interaction
Pathway map
oaa04060  Cytokine-cytokine receptor interaction
oaa04060

Organism
Ornithorhynchus anatinus (platypus) [GN:oaa]
Gene
100073393  CSF1; macrophage colony-stimulating factor 1 isoform X1 [KO:K05453]
100073530  IL6ST; interleukin-6 receptor subunit beta isoform X1 [KO:K05060]
100073680  TNFRSF9; tumor necrosis factor receptor superfamily member 9 [KO:K05146]
100073895  IL13RA1; interleukin-13 receptor subunit alpha-1 [KO:K05076]
100074403  NGF; LOW QUALITY PROTEIN: beta-nerve growth factor [KO:K02582]
100074584  CRLF2; cytokine receptor-like factor 2 [KO:K05078]
100074742  GDF11; growth/differentiation factor 11 [KO:K22679]
100074840  TGFB3; transforming growth factor beta-3 proprotein [KO:K13377]
100074849  TNFSF10; tumor necrosis factor ligand superfamily member 10 [KO:K04721]
100074930  IL12B; interleukin-12 subunit beta [KO:K05425]
100075136  IFNK; interferon kappa precursor [KO:K05414]
100075178  IL34; interleukin-34 isoform X1 [KO:K22633]
100075201  IL17RB; interleukin-17 receptor B isoform X1 [KO:K05165]
100075287  IFN1; type I interferon 1 [KO:K05414]
100075323  IFN3; type I interferon 3 [KO:K05414]
100075415  INHBA; inhibin beta A chain [KO:K04667]
100075416  BMP3; bone morphogenetic protein 3 [KO:K05496]
100075541  CCR6; C-C chemokine receptor type 6 [KO:K04181]
100075718  TNFRSF25; tumor necrosis factor receptor superfamily member 25 [KO:K05160]
100075809  IL17RA; interleukin-17 receptor A [KO:K05164]
100076167  LIFR; leukemia inhibitory factor receptor [KO:K05058]
100076213  OSMR; oncostatin-M-specific receptor subunit beta [KO:K05057]
100076274  GDF10; growth/differentiation factor 10 [KO:K22674]
100076307  GDF2; growth/differentiation factor 2 [KO:K05503]
100076541  TNFSF11; tumor necrosis factor ligand superfamily member 11 [KO:K05473]
100076721  TNFSF8; tumor necrosis factor ligand superfamily member 8 [KO:K05471]
100076790  [KO:K05478]
100076795  IL17RC; interleukin-17 receptor C isoform X1 [KO:K05166]
100076896  RELL2; RELT-like protein 2 [KO:K26541]
100076957  TNFRSF6B; tumor necrosis factor receptor superfamily member 6B [KO:K05143]
100076965  TGFBR2; TGF-beta receptor type-2 [KO:K04388] [EC:2.7.11.30]
100076985  IL1RL2; interleukin-1 receptor-like 2 [KO:K05172]
100077006  ACVR1; activin receptor type-1 isoform X2 [KO:K04675] [EC:2.7.11.30]
100077072  ACKR3; atypical chemokine receptor 3 [KO:K04304]
100077247  BMPR2; bone morphogenetic protein receptor type-2 isoform X1 [KO:K04671] [EC:2.7.11.30]
100077289  GDF15; LOW QUALITY PROTEIN: growth/differentiation factor 15 [KO:K05504]
100077352  IL10; interleukin-10 [KO:K05443]
100077806  IL22RA1; interleukin-22 receptor subunit alpha-1 isoform X1 [KO:K05138]
100077843  BMPR1A; bone morphogenetic protein receptor type-1A [KO:K04673] [EC:2.7.11.30]
100077931  IFNLR1; interferon lambda receptor 1 [KO:K05140]
100078019  [KO:K05424]
100078100  PRLR; prolactin receptor [KO:K05081]
100078271  IL17C; interleukin-17C [KO:K05491]
100078431  [KO:K05495]
100078445  IL7R; interleukin-7 receptor subunit alpha [KO:K05072]
100078574  IFNGR1; interferon gamma receptor 1 [KO:K05132]
100078655  IL20RA; interleukin-20 receptor subunit alpha [KO:K05136]
100078889  IL17A; interleukin-17A [KO:K05489]
100078988  [KO:K05494]
100079081  GDF9; growth/differentiation factor 9 isoform X1 [KO:K22673]
100079347  BMP7; bone morphogenetic protein 7 [KO:K16621]
100079376  IL21R; LOW QUALITY PROTEIN: interleukin-21 receptor [KO:K05075]
100079709  BMP15; bone morphogenetic protein 15 [KO:K05498]
100079713  CXCR4; C-X-C chemokine receptor type 4 [KO:K04189]
100079755  CSF1R; macrophage colony-stimulating factor 1 receptor [KO:K05090] [EC:2.7.10.1]
100079968  IFN5; type I interferon 5 precursor [KO:K05442]
100079998  IL12RB1; interleukin-12 receptor subunit beta-1 [KO:K05063]
100080173  CSF3R; granulocyte colony-stimulating factor receptor [KO:K05061]
100080176  TGFB2; transforming growth factor beta-2 proprotein isoform X1 [KO:K13376]
100080237  TNFRSF13B; tumor necrosis factor receptor superfamily member 13B [KO:K05150]
100080300  IL26; interleukin-26 [KO:K05446]
100080327  IL22; interleukin-22 [KO:K05445]
100080367  [KO:K05505]
100080388  [KO:K05505]
100080445  CCL22; C-C motif chemokine 22 [KO:K21095]
100080495  CX3CL1; fractalkine [KO:K05508]
100080533  GDF7; growth/differentiation factor 7 [KO:K20013]
100080823  IL17RE; interleukin-17 receptor E [KO:K05168]
100081046  TNFRSF21; LOW QUALITY PROTEIN: tumor necrosis factor receptor superfamily member 21 [KO:K05157]
100081314  LIF; leukemia inhibitory factor [KO:K05419]
100081526  LEPR; leptin receptor [KO:K05062]
100081575  ACVR1C; activin receptor type-1C isoform X2 [KO:K13568] [EC:2.7.11.30]
100081620  CCL4; C-C motif chemokine 4 [KO:K12964]
100081646  FASLG; tumor necrosis factor ligand superfamily member 6 [KO:K04389]
100081686  [KO:K04723]
100081726  IL23R; interleukin-23 receptor isoform X1 [KO:K05065]
100081756  IL12RB2; interleukin-12 receptor subunit beta-2 [KO:K05064]
100081994  MPL; thrombopoietin receptor [KO:K05082]
100082099  CXCL12; stromal cell-derived factor 1 isoform X2 [KO:K10031]
100082206  IL15; interleukin-15 [KO:K05433]
100082490  RELL1; RELT-like protein 1 [KO:K26541]
100082571  BMP5; bone morphogenetic protein 5 isoform X1 [KO:K04663]
100082925  IFNB1; interferon beta [KO:K05415]
100083042  CCR9; C-C chemokine receptor type 9 [KO:K04184]
100083160  XCR1; chemokine XC receptor 1 isoform X1 [KO:K04193]
100083187  [KO:K04176]
100083206  [KO:K04178]
100083227  [KO:K04180]
100083248  [KO:K04180]
100083298  IL6; interleukin-6 [KO:K05405]
100083427  PRL; prolactin [KO:K05439]
100083438  IFNGR2; interferon gamma receptor 2 isoform X1 [KO:K05133]
100083475  [KO:K05507]
100083477  IFNAR1; interferon alpha/beta receptor 1 [KO:K05130]
100083520  IL10RB; interleukin-10 receptor subunit beta [KO:K05135]
100083615  CD40LG; CD40 ligand [KO:K03161]
100083635  [KO:K05050]
100083684  BMP6; bone morphogenetic protein 6 [KO:K16620]
100083773  IL18; interleukin-18 [KO:K05482]
100084001  TNFRSF11A; tumor necrosis factor receptor superfamily member 11A [KO:K05147]
100084030  BMP2; bone morphogenetic protein 2 [KO:K21283]
100084042  IL1R2; interleukin-1 receptor type 2 [KO:K04387]
100084073  IL1R1; interleukin-1 receptor type 1 [KO:K04386]
100084092  IL1RL1; interleukin-1 receptor-like 1 [KO:K05171]
100084120  [KO:K05174]
100084246  TNFSF13B; tumor necrosis factor ligand superfamily member 13B [KO:K05476]
100084266  [KO:K21283]
100084425  CCR4; C-C chemokine receptor type 4 [KO:K04179]
100084720  TNFSF4; tumor necrosis factor ligand superfamily member 4 [KO:K05469]
100085252  [KO:K16622]
100085314  CXCL14; C-X-C motif chemokine 14 [KO:K10033]
100085329  EDAR; tumor necrosis factor receptor superfamily member EDAR [KO:K05162]
100085538  GHR; growth hormone receptor isoform X1 [KO:K05080]
100085643  TNF; tumor necrosis factor [KO:K03156]
100085680  ACVRL1; serine/threonine-protein kinase receptor R3 [KO:K13594] [EC:2.7.11.30]
100085735  TNFRSF1A; tumor necrosis factor receptor superfamily member 1A isoform X1 [KO:K03158]
100085782  CCL20; C-C motif chemokine 20 [KO:K14625]
100085840  IL20RB; interleukin-20 receptor subunit beta [KO:K05137]
100085842  IL15RA; interleukin-15 receptor subunit alpha [KO:K05074]
100086041  IL12A; interleukin-12 subunit alpha isoform X1 [KO:K05406]
100086400  ACVR2B; activin receptor type-2B [KO:K13596] [EC:2.7.11.30]
100086574  BMPR1B; bone morphogenetic protein receptor type-1B isoform X2 [KO:K13578] [EC:2.7.11.30]
100086592  GDF6; growth/differentiation factor 6 [KO:K20012]
100086997  TNFRSF11B; tumor necrosis factor receptor superfamily member 11B isoform X1 [KO:K05148]
100087023  TNFRSF17; tumor necrosis factor receptor superfamily member 17 [KO:K05153]
100087533  IL23A; interleukin-23 subunit alpha [KO:K05426]
100087585  CCR7; C-C chemokine receptor type 7 isoform X1 [KO:K04182]
100088007  EPOR; erythropoietin receptor [KO:K05079]
100088663  CNTFR; ciliary neurotrophic factor receptor subunit alpha isoform X1 [KO:K05059]
100088696  IL11RA; LOW QUALITY PROTEIN: interleukin-11 receptor subunit alpha [KO:K05056]
100088703  [KO:K16598]
100088749  IL17B; interleukin-17B [KO:K05490]
100088815  NODAL; nodal homolog [KO:K04666]
100089196  CX3CR1; CX3C chemokine receptor 1 [KO:K04192]
100089255  BMP4; bone morphogenetic protein 4 [KO:K04662]
100089487  IL17D; interleukin-17D [KO:K05492]
100089503  ACVR2A; activin receptor type-2A [KO:K04670] [EC:2.7.11.30]
100089840  INHA; inhibin alpha chain [KO:K05500]
100090625  ACVR1B; activin receptor type-1B [KO:K13567] [EC:2.7.11.30]
100090972  THPO; thrombopoietin [KO:K06854]
100091159  EBI3; interleukin-27 subunit beta [KO:K24476]
100091243  [KO:K22667]
100091362  IL19; interleukin-19 [KO:K05444]
100091552  TNFRSF12A; tumor necrosis factor receptor superfamily member 12A [KO:K05149]
100091625  NGFR; tumor necrosis factor receptor superfamily member 16 [KO:K02583]
100091652  MSTN; growth/differentiation factor 8 [KO:K05497]
100091990  [KO:K04175]
100092130  CLCF1; cardiotrophin-like cytokine factor 1 [KO:K05421]
100092209  [KO:K05422]
100092212  [KO:K24382]
100092358  TGFBR1; TGF-beta receptor type-1 [KO:K04674] [EC:2.7.11.30]
100092451  CCL21; C-C motif chemokine 21 [KO:K16062]
100092661  [KO:K05483]
100092682  IL1F10; interleukin-1 family member 10 [KO:K05488]
100092684  [KO:K05481]
100092851  IL2RB; interleukin-2 receptor subunit beta [KO:K05069]
100092995  LTB; lymphotoxin-beta [KO:K03157]
100093035  IL5RA; interleukin-5 receptor subunit alpha isoform X1 [KO:K05067]
100680604  CNTF; ciliary neurotrophic factor [KO:K05420]
100680688  IL27; interleukin-27 subunit alpha [KO:K22629]
100680807  TNFSF18; tumor necrosis factor ligand superfamily member 18 [KO:K05479]
100681550  ACKR4; atypical chemokine receptor 4 [KO:K04186]
103164858  EDA; ectodysplasin-A isoform X1 [KO:K05480]
103164911  IL4R; interleukin-4 receptor subunit alpha [KO:K05071]
103165091  FAS; tumor necrosis factor receptor superfamily member 6 isoform X1 [KO:K04390]
103165286  [KO:K04519]
103165339  CD4; T-cell surface glycoprotein CD4 isoform X1 [KO:K06454]
103165385  IL2RA; interleukin-2 receptor subunit alpha isoform X2 [KO:K05068]
103165717  IL27RA; interleukin-27 receptor subunit alpha [KO:K19598]
103165800  [KO:K05073]
103165905  IL5; interleukin-5 [KO:K05428]
103166056  RELT; tumor necrosis factor receptor superfamily member 19L [KO:K05156]
103166118  TNFRSF1B; tumor necrosis factor receptor superfamily member 1B isoform X1 [KO:K05141]
103166210  [KO:K04722]
103166465  [KO:K04722]
103166598  BMP10; bone morphogenetic protein 10 [KO:K22670]
103166612  [KO:K05435]
103166626  TNFRSF8; tumor necrosis factor receptor superfamily member 8 isoform X1 [KO:K05145]
103166696  TNFRSF18; tumor necrosis factor receptor superfamily member 18 isoform X1 [KO:K05154]
103166783  [KO:K05514]
103166888  CXCL17; C-X-C motif chemokine 17 [KO:K22627]
103167024  IL13RA2; interleukin-13 receptor subunit alpha-2 isoform X1 [KO:K05077]
103167037  CXCL16; C-X-C motif chemokine 16 [KO:K10035]
103167051  CSF2RB; cytokine receptor common subunit beta [KO:K04738]
103167286  INHBC; inhibin beta C chain [KO:K22688]
103167426  IL10RA; interleukin-10 receptor subunit alpha [KO:K05134]
103167686  IL16; pro-interleukin-16 [KO:K22628]
103169104  TNFRSF19; tumor necrosis factor receptor superfamily member 19 [KO:K05155]
103169233  IL18R1; interleukin-18 receptor 1 isoform X1 [KO:K05173]
103169510  [KO:K04722]
103169950  EDA2R; tumor necrosis factor receptor superfamily member 27 [KO:K05163]
103170562  [KO:K12672]
103170563  [KO:K12671]
103170567  [KO:K10030]
103170573  [KO:K12671]
103170687  IFNAR2; interferon alpha/beta receptor 2 [KO:K05131]
103170724  [KO:K05408]
103171076  CCL17; C-C motif chemokine 17 [KO:K21083]
103171352  TNFSF9; tumor necrosis factor ligand superfamily member 9 isoform X2 [KO:K05472]
103171371  [KO:K05491]
103171390  [KO:K05436]
103171402  [KO:K05066]
103171406  [KO:K05066]
107546820  [KO:K04183]
107547017  IL31RA; interleukin-31 receptor subunit alpha [KO:K22630]
107547155  CXCR6; C-X-C chemokine receptor type 6 [KO:K04191]
107547596  CXCR3; C-X-C chemokine receptor type 3 [KO:K04188]
114806015  GDF5; growth/differentiation factor 5 [KO:K04664]
114806068  CD40; tumor necrosis factor receptor superfamily member 5 [KO:K03160]
114806497  CD70; CD70 antigen [KO:K05470]
114806602  CCL25; C-C motif chemokine 25 isoform X1 [KO:K13072]
114807821  CD27; CD27 antigen [KO:K05144]
114807847  LTBR; tumor necrosis factor receptor superfamily member 3 isoform X1 [KO:K03159]
114807936  [KO:K12967]
114807941  [KO:K05414]
114807967  [KO:K05414]
114808091  EPO; erythropoietin [KO:K05437]
114808152  LTA; lymphotoxin-alpha [KO:K05468]
114808214  IL6R; interleukin-6 receptor subunit alpha [KO:K05055]
114808765  AMH; muellerian-inhibiting factor [KO:K04665]
114810112  [KO:K21283]
114810323  CCL19; C-C motif chemokine 19 [KO:K05512]
114811159  [KO:K05478]
114811187  INHBB; inhibin beta B chain [KO:K22687]
114812005  TGFB1; transforming growth factor beta-1 proprotein [KO:K13375]
114812035  TNFRSF4; tumor necrosis factor receptor superfamily member 4 isoform X1 [KO:K05142]
114812257  TNFRSF14; tumor necrosis factor receptor superfamily member 14 [KO:K05152]
114812802  IL2RG; cytokine receptor common subunit gamma [KO:K05070]
114813216  IL7; interleukin-7 [KO:K05431]
114814553  IL11; interleukin-11 [KO:K05417]
114814570  AMHR2; anti-Muellerian hormone type-2 receptor [KO:K04672] [EC:2.7.11.30]
114814573  [KO:K22689]
114815000  CSF3; granulocyte colony-stimulating factor [KO:K05423]
114815005  GH1; LOW QUALITY PROTEIN: somatotropin [KO:K05438]
114815075  CCR10; C-C chemokine receptor type 10 [KO:K04185]
114815153  CXCR5; C-X-C chemokine receptor type 5 [KO:K04190]
114816147  [KO:K02583]
114816193  IL25; interleukin-25 [KO:K05493]
114817929  [KO:K21097]
Reference
PMID:24892271
  Authors
Turner MD, Nedjai B, Hurst T, Pennington DJ
  Title
Cytokines and chemokines: At the crossroads of cell signalling and inflammatory disease.
  Journal
Biochim Biophys Acta 1843:2563-2582 (2014)
DOI:10.1016/j.bbamcr.2014.05.014
Reference
PMID:21106488
  Authors
Brocker C, Thompson D, Matsumoto A, Nebert DW, Vasiliou V
  Title
Evolutionary divergence and functions of the human interleukin (IL) gene family.
  Journal
Hum Genomics 5:30-55 (2010)
DOI:10.1186/1479-7364-5-1-30
Reference
PMID:27577879
  Authors
Akdis M, Aab A, Altunbulakli C, Azkur K, Costa RA, Crameri R, Duan S, Eiwegger T, Eljaszewicz A, Ferstl R, Frei R, Garbani M, Globinska A, Hess L, Huitema C, Kubo T, Komlosi Z, Konieczna P, Kovacs N, Kucuksezer UC, Meyer N, Morita H, Olzhausen J, O'Mahony L, Pezer M, Prati M, Rebane A, Rhyner C, Rinaldi A, Sokolowska M, Stanic B, Sugita K, Treis A, van de Veen W, Wanke K, Wawrzyniak M, Wawrzyniak P, Wirz OF, Zakzuk JS, Akdis CA
  Title
Interleukins (from IL-1 to IL-38), interferons, transforming growth factor beta, and TNF-alpha: Receptors, functions, and roles in diseases.
  Journal
J Allergy Clin Immunol 138:984-1010 (2016)
DOI:10.1016/j.jaci.2016.06.033
Reference
PMID:15500860
  Authors
Boulanger MJ, Garcia KC
  Title
Shared cytokine signaling receptors: structural insights from the gp130 system.
  Journal
Adv Protein Chem 68:107-46 (2004)
DOI:10.1016/S0065-3233(04)68004-1
Reference
PMID:16034365
  Authors
Allan SM, Tyrrell PJ, Rothwell NJ
  Title
Interleukin-1 and neuronal injury.
  Journal
Nat Rev Immunol 5:629-40 (2005)
DOI:10.1038/nri1664
Reference
PMID:23847622
  Authors
Lopetuso LR, Chowdhry S, Pizarro TT
  Title
Opposing Functions of Classic and Novel IL-1 Family Members in Gut Health and Disease.
  Journal
Front Immunol 4:181 (2013)
DOI:10.3389/fimmu.2013.00181
Reference
PMID:21349428
  Authors
Iwakura Y, Ishigame H, Saijo S, Nakae S
  Title
Functional specialization of interleukin-17 family members.
  Journal
Immunity 34:149-62 (2011)
DOI:10.1016/j.immuni.2011.02.012
Reference
PMID:17530315
  Authors
Fischer P, Hilfiker-Kleiner D
  Title
Survival pathways in hypertrophy and heart failure: the gp130-STAT3 axis.
  Journal
Basic Res Cardiol 102:279-97 (2007)
DOI:10.1007/s00395-007-0658-z
Reference
PMID:24381786
  Authors
Richards CD
  Title
The enigmatic cytokine oncostatin m and roles in disease.
  Journal
ISRN Inflamm 2013:512103 (2013)
DOI:10.1155/2013/512103
Reference
PMID:18926762
  Authors
Zhang Q, Putheti P, Zhou Q, Liu Q, Gao W
  Title
Structures and biological functions of IL-31 and IL-31 receptors.
  Journal
Cytokine Growth Factor Rev 19:347-56 (2008)
DOI:10.1016/j.cytogfr.2008.08.003
Reference
PMID:21155715
  Authors
Meenhuis A, Verwijmeren C, Roovers O, Touw IP
  Title
The deubiquitinating enzyme DUB2A enhances CSF3 signalling by attenuating lysosomal routing of the CSF3 receptor.
  Journal
Biochem J 434:343-51 (2011)
DOI:10.1042/BJ20101628
Reference
PMID:22410872
  Authors
de Weerd NA, Nguyen T
  Title
The interferons and their receptors--distribution and regulation.
  Journal
Immunol Cell Biol 90:483-91 (2012)
DOI:10.1038/icb.2012.9
Reference
PMID:12949498
  Authors
Aggarwal BB
  Title
Signalling pathways of the TNF superfamily: a double-edged sword.
  Journal
Nat Rev Immunol 3:745-56 (2003)
DOI:10.1038/nri1184
Reference
PMID:12189384
  Authors
Ashkenazi A
  Title
Targeting death and decoy receptors of the tumour-necrosis factor superfamily.
  Journal
Nat Rev Cancer 2:420-30 (2002)
DOI:10.1038/nrc821
Reference
PMID:26115564
  Authors
Seeger P, Musso T, Sozzani S
  Title
The TGF-beta superfamily in dendritic cell biology.
  Journal
Cytokine Growth Factor Rev 26:647-57 (2015)
DOI:10.1016/j.cytogfr.2015.06.002
Reference
PMID:23612460
  Authors
Wakefield LM, Hill CS
  Title
Beyond TGFbeta: roles of other TGFbeta superfamily members in cancer.
  Journal
Nat Rev Cancer 13:328-41 (2013)
DOI:10.1038/nrc3500
Reference
PMID:22710174
  Authors
Mueller TD, Nickel J
  Title
Promiscuity and specificity in BMP receptor activation.
  Journal
FEBS Lett 586:1846-59 (2012)
DOI:10.1016/j.febslet.2012.02.043
KO pathway
ko04060   

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