KEGG   PATHWAY: aamp04020
Entry
aamp04020                   Pathway                                
Name
Calcium signaling pathway - Arvicola amphibius (Eurasian water vole)
Description
Ca2+ that enters the cell from the outside is a principal source of signal Ca2+. Entry of Ca2+ is driven by the presence of a large electrochemical gradient across the plasma membrane. Cells use this external source of signal Ca2+ by activating various entry channels with widely different properties. The voltage-operated channels (VOCs) are found in excitable cells and generate the rapid Ca2+ fluxes that control fast cellular processes. There are many other Ca2+-entry channels, such as the receptor-operated channels (ROCs), for example the NMDA (N-methyl-D-aspartate) receptors (NMDARs) that respond to glutamate. There also are second-messenger-operated channels (SMOCs) and store-operated channels (SOCs).
The other principal source of Ca2+ for signalling is the internal stores that are located primarily in the endoplasmic/sarcoplasmic reticulum (ER/SR), in which inositol-1,4,5-trisphosphate receptors (IP3Rs) or ryanodine receptors (RYRs) regulate the release of Ca2+. The principal activator of these channels is Ca2+ itself and this process of Ca2+-induced Ca2+ release is central to the mechanism of Ca2+ signalling. Various second messengers or modulators also control the release of Ca2+. IP3, which is generated by pathways using different isoforms of phospholipase C (PLCbeta, delta, epsilon, gamma and zeta), regulates the IP3Rs. Cyclic ADP-ribose (cADPR) releases Ca2+ via RYRs. Nicotinic acid adenine dinucleotide phosphate (NAADP) may activate a distinct Ca2+ release mechanism on separate acidic Ca2+ stores. Ca2+ release via the NAADP-sensitive mechanism may also feedback onto either RYRs or IP3Rs. cADPR and NAADP are generated by CD38. This enzyme might be sensitive to the cellular metabolism, as ATP and NADH inhibit it.
The influx of Ca2+ from the environment or release from internal stores causes a very rapid and dramatic increase in cytoplasmic calcium concentration, which has been widely exploited for signal transduction. Some proteins, such as troponin C (TnC) involved in muscle contraction, directly bind to and sense Ca2+. However, in other cases Ca2+ is sensed through intermediate calcium sensors such as calmodulin (CALM).
Class
Environmental Information Processing; Signal transduction
Pathway map
aamp04020  Calcium signaling pathway
aamp04020

Other DBs
GO: 0019722
Organism
Arvicola amphibius (Eurasian water vole) [GN:aamp]
Gene
119808074  Slc8a1; sodium/calcium exchanger 1 isoform X1 [KO:K05849]
119820931  Slc8a2; sodium/calcium exchanger 2 isoform X1 [KO:K05849]
119818947  Slc8a3; sodium/calcium exchanger 3 isoform X1 [KO:K05849]
119803270  Atp2b1; plasma membrane calcium-transporting ATPase 1 isoform X1 [KO:K05850] [EC:7.2.2.10]
119804770  Atp2b3; plasma membrane calcium-transporting ATPase 3 isoform X1 [KO:K05850] [EC:7.2.2.10]
119806733  Atp2b2; plasma membrane calcium-transporting ATPase 2 isoform X1 [KO:K05850] [EC:7.2.2.10]
119827236  Atp2b4; plasma membrane calcium-transporting ATPase 4 isoform X1 [KO:K05850] [EC:7.2.2.10]
119799823  Chrm1; muscarinic acetylcholine receptor M1 [KO:K04129]
119816034  Chrm3; muscarinic acetylcholine receptor M3 isoform X1 [KO:K04131]
119815576  Chrm5; LOW QUALITY PROTEIN: muscarinic acetylcholine receptor M5 [KO:K04133]
119823149  Adora2a; adenosine receptor A2a [KO:K04266]
119812821  Adora2b; adenosine receptor A2b [KO:K04267]
119804182  Adrb1; beta-1 adrenergic receptor [KO:K04141]
119814920  Adrb2; beta-2 adrenergic receptor [KO:K04142]
119813409  Adrb3; beta-3 adrenergic receptor [KO:K04143]
119818024  Drd1; D(1A) dopamine receptor [KO:K04144]
119812920  Drd5; D(1B) dopamine receptor [KO:K05840]
119817835  Hrh2; histamine H2 receptor isoform X1 [KO:K04150]
119815369  Htr4; 5-hydroxytryptamine receptor 4 [KO:K04160]
119808396  Htr5a; 5-hydroxytryptamine receptor 5A [KO:K04161]
119799552  5-hydroxytryptamine receptor 5B [KO:K04161]
119816086  Htr6; 5-hydroxytryptamine receptor 6 [KO:K04162]
119827818  Htr7; 5-hydroxytryptamine receptor 7 [KO:K04163]
119814107  Gnas; guanine nucleotide-binding protein G(s) subunit alpha isoforms XLas isoform X1 [KO:K04632]
119814944  neuroendocrine secretory protein 55 isoform X1 [KO:K04632]
119814407  Gnal; guanine nucleotide-binding protein G(olf) subunit alpha isoform X1 [KO:K04633]
119800365  Adcy1; adenylate cyclase type 1 [KO:K08041] [EC:4.6.1.1]
119809754  Adcy2; adenylate cyclase type 2 [KO:K08042] [EC:4.6.1.1]
119807554  Adcy3; adenylate cyclase type 3 isoform X1 [KO:K08043] [EC:4.6.1.1]
119800380  Adcy4; adenylate cyclase type 4 [KO:K08044] [EC:4.6.1.1]
119801694  Adcy7; adenylate cyclase type 7 isoform X1 [KO:K08047] [EC:4.6.1.1]
119823121  Adcy8; adenylate cyclase type 8 isoform X1 [KO:K08048] [EC:4.6.1.1]
119811771  Adcy9; adenylate cyclase type 9 isoform X1 [KO:K08049] [EC:4.6.1.1]
119800975  Prkacb; LOW QUALITY PROTEIN: cAMP-dependent protein kinase catalytic subunit beta [KO:K04345] [EC:2.7.11.11]
119802004  Prkaca; cAMP-dependent protein kinase catalytic subunit alpha [KO:K04345] [EC:2.7.11.11]
119820485  Pln; cardiac phospholamban [KO:K05852]
119808849  Sln; sarcolipin [KO:K22642]
119822269  Mrln; myoregulin [KO:K22643]
119801139  C14H4orf3; uncharacterized protein C4orf3 homolog [KO:K26467]
119824551  Atp2a2; sarcoplasmic/endoplasmic reticulum calcium ATPase 2 [KO:K05853] [EC:7.2.2.10]
119826284  Atp2a1; sarcoplasmic/endoplasmic reticulum calcium ATPase 1 isoform X1 [KO:K05853] [EC:7.2.2.10]
119813074  Atp2a3; sarcoplasmic/endoplasmic reticulum calcium ATPase 3 isoform X1 [KO:K05853] [EC:7.2.2.10]
119803070  Hrc; sarcoplasmic reticulum histidine-rich calcium-binding protein isoform X1 [KO:K23450]
119814158  Stim1; stromal interaction molecule 1 isoform X1 [KO:K16059]
119827280  Stim2; LOW QUALITY PROTEIN: stromal interaction molecule 2 [KO:K18196]
119824929  Orai1; calcium release-activated calcium channel protein 1 [KO:K16056]
119825081  Orai2; protein orai-2 [KO:K16057]
119815733  Orai3; protein orai-3 [KO:K16058]
119806908  Cacna1c; voltage-dependent L-type calcium channel subunit alpha-1C isoform X1 [KO:K04850]
119828004  Cacna1d; voltage-dependent L-type calcium channel subunit alpha-1D isoform X1 [KO:K04851]
119804579  Cacna1f; voltage-dependent L-type calcium channel subunit alpha-1F [KO:K04853]
119827234  Cacna1s; voltage-dependent L-type calcium channel subunit alpha-1S isoform X1 [KO:K04857]
119801772  Cacna1a; LOW QUALITY PROTEIN: voltage-dependent P/Q-type calcium channel subunit alpha-1A [KO:K04344]
119818472  Cacna1b; voltage-dependent N-type calcium channel subunit alpha-1B isoform X1 [KO:K04849]
119827366  Cacna1e; voltage-dependent R-type calcium channel subunit alpha-1E isoform X1 [KO:K04852]
119811216  Cacna1g; voltage-dependent T-type calcium channel subunit alpha-1G isoform X1 [KO:K04854]
119811778  Cacna1h; voltage-dependent T-type calcium channel subunit alpha-1H isoform X1 [KO:K04855]
119822616  Cacna1i; voltage-dependent T-type calcium channel subunit alpha-1I [KO:K04856]
119802858  Chrna7; neuronal acetylcholine receptor subunit alpha-7 [KO:K04809]
119818834  Grin1; glutamate receptor ionotropic, NMDA 1 isoform X1 [KO:K05208]
119812911  Grin2a; glutamate receptor ionotropic, NMDA 2A isoform X1 [KO:K05209]
119806515  Grin2b; glutamate receptor ionotropic, NMDA 2B [KO:K05210]
119812477  Grin2c; glutamate receptor ionotropic, NMDA 2C [KO:K05211]
119802465  Grin2d; glutamate receptor ionotropic, NMDA 2D [KO:K05212]
119826595  Grin3a; glutamate receptor ionotropic, NMDA 3A isoform X1 [KO:K05213]
119826753  Grin3b; glutamate receptor ionotropic, NMDA 3B [KO:K05214]
119812803  P2rx1; P2X purinoceptor 1 [KO:K05215]
119825287  P2rx2; P2X purinoceptor 2 isoform X1 [KO:K05216]
119819251  P2rx3; P2X purinoceptor 3 [KO:K05217]
119824911  P2rx4; P2X purinoceptor 4 isoform X1 [KO:K05218]
119813112  P2rx5; LOW QUALITY PROTEIN: P2X purinoceptor 5 [KO:K05219]
119825108  P2rx6; P2X purinoceptor 6 isoform X1 [KO:K05221]
119824968  P2rx7; P2X purinoceptor 7 [KO:K05220]
119820756  Ryr1; ryanodine receptor 1 isoform X1 [KO:K04961]
119817089  Ryr2; ryanodine receptor 2 [KO:K04962]
119815223  Ryr3; ryanodine receptor 3 [KO:K04963]
119821694  Trdn; triadin [KO:K23449]
119827896  Casq1; calsequestrin-1 [KO:K23468]
119800655  Casq2; calsequestrin-2 [KO:K23445]
119826126  Asph; aspartyl/asparaginyl beta-hydroxylase isoform X1 [KO:K00476] [EC:1.14.11.16]
119804825  Cysltr1; cysteinyl leukotriene receptor 1 [KO:K04322]
119799799  Cysltr2; cysteinyl leukotriene receptor 2 [KO:K04323]
119808071  Chrm2; muscarinic acetylcholine receptor M2 [KO:K04130]
119800256  Adra1a; LOW QUALITY PROTEIN: alpha-1A adrenergic receptor [KO:K04135]
119811133  Adra1b; alpha-1B adrenergic receptor isoform X1 [KO:K04136]
119814901  Adra1d; alpha-1D adrenergic receptor [KO:K04137]
119817416  type-1A angiotensin II receptor [KO:K04166]
119826658  Agtr1; type-1 angiotensin II receptor [KO:K04166]
119801904  Ednra; endothelin-1 receptor [KO:K04197]
119800039  Ednrb; endothelin receptor type B [KO:K04198]
119809677  F2r; proteinase-activated receptor 1 [KO:K03914]
119821203  Grm1; metabotropic glutamate receptor 1 [KO:K04603]
119802846  Grm5; LOW QUALITY PROTEIN: metabotropic glutamate receptor 5 [KO:K04604]
119805460  Grpr; gastrin-releasing peptide receptor [KO:K04169]
119808005  Hrh1; histamine H1 receptor [KO:K04149]
119800490  Htr2a; 5-hydroxytryptamine receptor 2A [KO:K04157]
119805370  Htr2c; 5-hydroxytryptamine receptor 2C [KO:K04157]
119820513  Htr2b; LOW QUALITY PROTEIN: 5-hydroxytryptamine receptor 2B [KO:K04157]
119808150  Lhcgr; lutropin-choriogonadotropic hormone receptor [KO:K04248]
119814023  Ntsr1; neurotensin receptor type 1 [KO:K04211]
119808366  Oxtr; oxytocin receptor [KO:K04229]
119803492  Avpr1a; vasopressin V1a receptor [KO:K04226]
119827544  Avpr1b; vasopressin V1b receptor [KO:K04227]
119800134  Ltb4r2; leukotriene B4 receptor 2 [KO:K04297]
119816638  Ptafr; platelet-activating factor receptor [KO:K04279]
119801837  Ptger1; prostaglandin E2 receptor EP1 subtype [KO:K04258]
119801494  Ptger3; prostaglandin E2 receptor EP3 subtype [KO:K04260]
119800588  Ptgfr; prostaglandin F2-alpha receptor [KO:K04262]
119818371  Bdkrb1; B1 bradykinin receptor [KO:K03915]
119819935  Bdkrb2; B2 bradykinin receptor [KO:K03916]
119808176  Tacr1; substance-P receptor [KO:K04222]
119823430  Tacr2; substance-K receptor [KO:K04223]
119801367  Tacr3; neuromedin-K receptor [KO:K04224]
119823837  Tbxa2r; thromboxane A2 receptor [KO:K04264]
119801616  thyrotropin-releasing hormone receptor-like [KO:K04282]
119824054  Trhr; thyrotropin-releasing hormone receptor [KO:K04282]
119801999  Cckar; cholecystokinin receptor type A [KO:K04194]
119824372  Cckbr; gastrin/cholecystokinin type B receptor isoform X1 [KO:K04195]
119827638  Cxcr4; C-X-C chemokine receptor type 4 [KO:K04189]
119812597  guanine nucleotide-binding protein G(q) subunit alpha [KO:K04634]
119827968  Gna11; guanine nucleotide-binding protein subunit alpha-11 [KO:K04635]
119815260  guanine nucleotide-binding protein subunit alpha-14 [KO:K04636]
119803981  Gna15; guanine nucleotide-binding protein subunit alpha-15 isoform X1 [KO:K04637]
119800992  Egf; pro-epidermal growth factor [KO:K04357]
119807169  Tgfa; protransforming growth factor alpha [KO:K08774]
119825753  Pdgfa; platelet-derived growth factor subunit A isoform X1 [KO:K04359]
119823283  Pdgfb; platelet-derived growth factor subunit B [KO:K17386]
119810057  Pdgfd; platelet-derived growth factor D isoform X1 [KO:K05450]
119826417  Pdgfc; platelet-derived growth factor C isoform X1 [KO:K05450]
119814061  Fgf1; fibroblast growth factor 1 isoform X1 [KO:K18496]
119826229  Fgf2; fibroblast growth factor 2 [KO:K18497]
119800369  Fgf17; fibroblast growth factor 17 isoform X1 [KO:K04358]
119800397  Fgf9; fibroblast growth factor 9 [KO:K04358]
119814352  Fgf7; fibroblast growth factor 7 [KO:K04358]
119808412  Fgf6; fibroblast growth factor 6 [KO:K04358]
119808698  Fgf10; fibroblast growth factor 10 [KO:K04358]
119802892  Fgf22; fibroblast growth factor 22 isoform X1 [KO:K04358]
119812198  Fgf3; fibroblast growth factor 3 [KO:K04358]
119805412  Fgf16; fibroblast growth factor 16 [KO:K04358]
119825456  Fgf8; fibroblast growth factor 8 isoform X1 [KO:K04358]
119805928  Fgf5; fibroblast growth factor 5 [KO:K04358]
119805944  Fgf4; fibroblast growth factor 4 [KO:K04358]
119813362  Fgf20; fibroblast growth factor 20 [KO:K04358]
119806542  Fgf19; fibroblast growth factor 19 [KO:K22603]
119802871  Fgf21; fibroblast growth factor 21 [KO:K22429]
119807114  Fgf23; fibroblast growth factor 23 [KO:K22428]
119822340  vascular endothelial growth factor A-like [KO:K05448]
119822341  vascular endothelial growth factor A-like isoform X1 [KO:K05448]
119801722  Vegfb; vascular endothelial growth factor B isoform X1 [KO:K16858]
119812191  Vegfc; vascular endothelial growth factor C [KO:K05449]
119805399  Vegfd; LOW QUALITY PROTEIN: vascular endothelial growth factor D [KO:K05449]
119801207  Ngf; beta-nerve growth factor [KO:K02582]
119803884  Hgf; hepatocyte growth factor isoform X1 [KO:K05460]
119809747  Mst1; hepatocyte growth factor-like protein isoform X1 [KO:K23441]
119810480  Gdnf; glial cell line-derived neurotrophic factor isoform X1 [KO:K05452]
119812357  Egfr; epidermal growth factor receptor isoform X1 [KO:K04361] [EC:2.7.10.1]
119811725  Erbb2; receptor tyrosine-protein kinase erbB-2 [KO:K05083] [EC:2.7.10.1]
119803504  Erbb3; receptor tyrosine-protein kinase erbB-3 [KO:K05084] [EC:2.7.10.1]
119821978  Erbb4; receptor tyrosine-protein kinase erbB-4 [KO:K05085] [EC:2.7.10.1]
119807129  Pdgfra; platelet-derived growth factor receptor alpha [KO:K04363] [EC:2.7.10.1]
119815474  Pdgfrb; platelet-derived growth factor receptor beta isoform X1 [KO:K05089] [EC:2.7.10.1]
119811944  Fgfr1; fibroblast growth factor receptor 1 isoform X1 [KO:K04362] [EC:2.7.10.1]
119827742  Fgfr2; fibroblast growth factor receptor 2 isoform X1 [KO:K05093] [EC:2.7.10.1]
119805838  LOW QUALITY PROTEIN: fibroblast growth factor receptor 3-like [KO:K05094] [EC:2.7.10.1]
119805848  LOW QUALITY PROTEIN: fibroblast growth factor receptor 3-like [KO:K05094] [EC:2.7.10.1]
119811014  fibroblast growth factor receptor 3-like isoform X1 [KO:K05094] [EC:2.7.10.1]
119811259  fibroblast growth factor receptor 3-like [KO:K05094] [EC:2.7.10.1]
119812129  Fgfr3; fibroblast growth factor receptor 3 isoform X1 [KO:K05094] [EC:2.7.10.1]
119805744  fibroblast growth factor receptor 3-like isoform X1 [KO:K05094] [EC:2.7.10.1]
119805841  LOW QUALITY PROTEIN: fibroblast growth factor receptor 3-like [KO:K05094] [EC:2.7.10.1]
119805908  fibroblast growth factor receptor 3-like [KO:K05094] [EC:2.7.10.1]
119816377  Fgfr4; fibroblast growth factor receptor 4 [KO:K05095] [EC:2.7.10.1]
119824995  Flt1; vascular endothelial growth factor receptor 1 [KO:K05096] [EC:2.7.10.1]
119813056  Flt4; vascular endothelial growth factor receptor 3 [KO:K05097] [EC:2.7.10.1]
119813736  Kdr; vascular endothelial growth factor receptor 2 [KO:K05098] [EC:2.7.10.1]
119800869  Ntrk1; high affinity nerve growth factor receptor isoform X1 [KO:K03176] [EC:2.7.10.1]
119816678  Ntrk2; BDNF/NT-3 growth factors receptor isoform X1 [KO:K04360] [EC:2.7.10.1]
119802626  Ntrk3; LOW QUALITY PROTEIN: NT-3 growth factor receptor [KO:K05101] [EC:2.7.10.1]
119806540  Met; hepatocyte growth factor receptor [KO:K05099] [EC:2.7.10.1]
119810058  Mst1r; macrophage-stimulating protein receptor isoform X1 [KO:K05100] [EC:2.7.10.1]
119807136  Ret; proto-oncogene tyrosine-protein kinase receptor Ret [KO:K05126] [EC:2.7.10.1]
119821454  Plcd4; 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase delta-4 isoform X1 [KO:K05857] [EC:3.1.4.11]
119809518  Plcd1; 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase delta-1 isoform X1 [KO:K05857] [EC:3.1.4.11]
119812535  Plcd3; 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase delta-3 isoform X1 [KO:K05857] [EC:3.1.4.11]
119814344  Plcb2; 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-2 isoform X1 [KO:K05858] [EC:3.1.4.11]
119814366  Plcb1; 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-1 isoform X1 [KO:K05858] [EC:3.1.4.11]
119814933  Plcb4; 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-4 [KO:K05858] [EC:3.1.4.11]
119824882  Plcb3; 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-3 [KO:K05858] [EC:3.1.4.11]
119814207  Plcg1; 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1 isoform X1 [KO:K01116] [EC:3.1.4.11]
119801950  Plcg2; 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-2 [KO:K05859] [EC:3.1.4.11]
119809417  Plce1; 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase epsilon-1 [KO:K05860] [EC:3.1.4.11]
119806503  Plcz1; 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase zeta-1 [KO:K05861] [EC:3.1.4.11]
119806390  Itpr1; inositol 1,4,5-trisphosphate receptor type 1 isoform X1 [KO:K04958]
119806213  Itpr2; LOW QUALITY PROTEIN: inositol 1,4,5-trisphosphate receptor type 2 [KO:K04959]
119823109  Itpr3; inositol 1,4,5-trisphosphate receptor type 3 [KO:K04960]
119804718  Cd38; ADP-ribosyl cyclase/cyclic ADP-ribose hydrolase 1 [KO:K01242] [EC:3.2.2.6 2.4.99.20]
119825517  Tpcn1; LOW QUALITY PROTEIN: two pore calcium channel protein 1 [KO:K16896]
119800160  Tpcn2; two pore calcium channel protein 2 isoform X1 [KO:K14077]
119825460  Mcoln1; mucolipin-1 isoform X1 [KO:K04992]
119801097  Mcoln2; mucolipin-2 [KO:K04993]
119801114  Mcoln3; mucolipin-3 isoform X1 [KO:K04994]
119802538  Sphk2; sphingosine kinase 2 isoform X1 [KO:K04718] [EC:2.7.1.91]
119812963  Sphk1; sphingosine kinase 1 [KO:K04718] [EC:2.7.1.91]
119823855  Mcu; calcium uniporter protein, mitochondrial [KO:K20858]
119812709  Vdac1; LOW QUALITY PROTEIN: voltage-dependent anion-selective channel protein 1 [KO:K05862]
119800149  Vdac2; voltage-dependent anion-selective channel protein 2 [KO:K15040]
119812859  Vdac3; voltage-dependent anion-selective channel protein 3 [KO:K15041]
119807859  ADP/ATP translocase 2-like [KO:K05863]
119800309  ADP/ATP translocase 2-like [KO:K05863]
119815168  ADP/ATP translocase 2-like [KO:K05863]
119817121  LOW QUALITY PROTEIN: ADP/ATP translocase 1-like [KO:K05863]
119804458  ADP/ATP translocase 2-like [KO:K05863]
119804649  Slc25a5; ADP/ATP translocase 2 [KO:K05863]
119812148  Slc25a4; ADP/ATP translocase 1 [KO:K05863]
119812681  ADP/ATP translocase 2-like [KO:K05863]
119819282  ADP/ATP translocase 2-like [KO:K05863]
119826727  Slc25a31; LOW QUALITY PROTEIN: ADP/ATP translocase 4 [KO:K05863]
119827941  Ppif; peptidyl-prolyl cis-trans isomerase F, mitochondrial [KO:K09565] [EC:5.2.1.8]
119827956  Tnnc1; troponin C, slow skeletal and cardiac muscles isoform X1 [KO:K05865]
119814362  Tnnc2; troponin C, skeletal muscle [KO:K12042]
119821021  Calm3; calmodulin-3 [KO:K02183]
119808332  Calm2; calmodulin-2 [KO:K02183]
119808754  Calml4; calmodulin-like protein 4 [KO:K02183]
119809106  calmodulin-1 [KO:K02183]
119815477  calmodulin-1 [KO:K02183]
119817551  Calml3; calmodulin-like protein 3 [KO:K02183]
119817552  calmodulin-4-like [KO:K02183]
119818370  Calm1; calmodulin-1 [KO:K02183]
119825273  Phkg1; phosphorylase b kinase gamma catalytic chain, skeletal muscle/heart isoform [KO:K00871] [EC:2.7.11.19]
119807018  Phkg2; phosphorylase b kinase gamma catalytic chain, liver/testis isoform isoform X1 [KO:K00871] [EC:2.7.11.19]
119801764  Phkb; phosphorylase b kinase regulatory subunit beta isoform X1 [KO:K07190]
119804574  Phka2; phosphorylase b kinase regulatory subunit alpha, liver isoform isoform X1 [KO:K07190]
119804692  Phka1; phosphorylase b kinase regulatory subunit alpha, skeletal muscle isoform isoform X1 [KO:K07190]
119815079  Mylk2; myosin light chain kinase 2, skeletal/cardiac muscle isoform X1 [KO:K00907] [EC:2.7.11.18]
119817116  Mylk4; myosin light chain kinase family member 4 [KO:K00907] [EC:2.7.11.18]
119802026  Mylk3; myosin light chain kinase 3 [KO:K00907] [EC:2.7.11.18]
119824616  Mylk; myosin light chain kinase, smooth muscle isoform X1 [KO:K00907] [EC:2.7.11.18]
119827641  Camk1g; calcium/calmodulin-dependent protein kinase type 1G [KO:K08794] [EC:2.7.11.17]
119806937  Camk1; calcium/calmodulin-dependent protein kinase type 1 isoform X1 [KO:K08794] [EC:2.7.11.17]
119800462  Camk2g; calcium/calmodulin-dependent protein kinase type II subunit gamma isoform X1 [KO:K04515] [EC:2.7.11.17]
119800784  Camk2d; calcium/calmodulin-dependent protein kinase type II subunit delta isoform X1 [KO:K04515] [EC:2.7.11.17]
119808786  Camk2b; calcium/calmodulin-dependent protein kinase type II subunit beta isoform X1 [KO:K04515] [EC:2.7.11.17]
119814221  Camk2a; calcium/calmodulin-dependent protein kinase type II subunit alpha isoform X1 [KO:K04515] [EC:2.7.11.17]
119814676  Camk4; calcium/calmodulin-dependent protein kinase type IV [KO:K05869] [EC:2.7.11.17]
119800939  Ppp3ca; serine/threonine-protein phosphatase 2B catalytic subunit alpha isoform [KO:K04348] [EC:3.1.3.16]
119800012  Ppp3cb; serine/threonine-protein phosphatase 2B catalytic subunit beta isoform isoform X1 [KO:K04348] [EC:3.1.3.16]
119800123  Ppp3cc; serine/threonine-protein phosphatase 2B catalytic subunit gamma isoform isoform X1 [KO:K04348] [EC:3.1.3.16]
119823004  Ppp3r1; calcineurin subunit B type 1 [KO:K06268]
119826596  Ppp3r2; calcineurin subunit B type 2 [KO:K06268]
119823868  Tfeb; transcription factor EB isoform X1 [KO:K15590]
119814795  Nfatc1; nuclear factor of activated T-cells, cytoplasmic 1 isoform X1 [KO:K04446]
119815528  Nfatc2; nuclear factor of activated T-cells, cytoplasmic 2 isoform X1 [KO:K17332]
119801672  Nfatc3; nuclear factor of activated T-cells, cytoplasmic 3 isoform X1 [KO:K17333]
119800411  Nfatc4; nuclear factor of activated T-cells, cytoplasmic 4 isoform X1 [KO:K17334]
119824418  Nos1; LOW QUALITY PROTEIN: nitric oxide synthase, brain [KO:K13240] [EC:1.14.13.39]
119811441  Nos2; nitric oxide synthase, inducible [KO:K13241] [EC:1.14.13.39]
119807052  Nos3; LOW QUALITY PROTEIN: nitric oxide synthase, endothelial [KO:K13242] [EC:1.14.13.39]
119823496  Pde1b; calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1B isoform X1 [KO:K13755] [EC:3.1.4.17]
119818682  Pde1a; LOW QUALITY PROTEIN: calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A [KO:K13755] [EC:3.1.4.17]
119807068  Pde1c; calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1C isoform X1 [KO:K13755] [EC:3.1.4.17]
119799720  Ptk2b; protein-tyrosine kinase 2-beta isoform X1 [KO:K05871] [EC:2.7.10.2]
119828049  Itpkb; inositol-trisphosphate 3-kinase B [KO:K00911] [EC:2.7.1.127]
119815397  Itpka; inositol-trisphosphate 3-kinase A [KO:K00911] [EC:2.7.1.127]
119820337  Itpkc; inositol-trisphosphate 3-kinase C [KO:K00911] [EC:2.7.1.127]
119812144  Prkca; protein kinase C alpha type [KO:K02677] [EC:2.7.11.13]
119822917  Prkcb; protein kinase C beta type isoform X1 [KO:K19662] [EC:2.7.11.13]
119820784  Prkcg; protein kinase C gamma type [KO:K19663] [EC:2.7.11.13]
Compound
C00002  ATP
C00004  NADH
C00076  Calcium cation
C00165  Diacylglycerol
C00575  3',5'-Cyclic AMP
C01245  D-myo-Inositol 1,4,5-trisphosphate
C01330  Sodium cation
C06124  Sphingosine 1-phosphate
C11556  1-Phosphatidyl-1D-myo-inositol 3,5-bisphosphate
C13050  Cyclic ADP-ribose
C13051  Nicotinic acid adenine dinucleotide phosphate
Reference
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Berridge MJ, Bootman MD, Roderick HL.
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Calcium signalling: dynamics, homeostasis and remodelling.
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Nat Rev Mol Cell Biol 4:517-29 (2003)
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PMID:11413485
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The versatility and universality of calcium signalling.
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Nat Rev Mol Cell Biol 1:11-21 (2000)
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PMID:15111104
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Cardiac excitation-contraction coupling: role of membrane potential in regulation of contraction.
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Am J Physiol Cell Physiol 281:C1743-56 (2001)
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Reference
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Calcineurin regulation of synaptic function: from ion channels to transmitter release and gene transcription.
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Trends Pharmacol Sci 18:124-34 (1997)
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Reference
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Ras-dependent mitogen-activated protein kinase activation by G protein-coupled receptors. Convergence of Gi- and Gq-mediated pathways on calcium/calmodulin, Pyk2, and Src kinase.
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J Biol Chem 272:19125-32 (1997)
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Reference
PMID:7861177
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Inositol 1, 4, 5-trisphosphate receptor-mediated Ca2+ signaling in the brain.
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J Neurochem 64:953-60 (1995)
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Reference
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Crosstalk between cAMP and Ca2+ signaling in non-excitable cells.
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Cell Calcium 34:431-44 (2003)
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Reference
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Structures and activities of cyclic ADP-ribose, NAADP and their metabolic enzymes.
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Mol Cell Biochem 193:89-98 (1999)
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Reference
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Mitochondrial intermembrane junctional complexes and their role in cell death.
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J Physiol 529 Pt 1:11-21 (2000)
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Extracellular-signal-regulated kinase signalling in neurons.
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Protein kinase Calpha (PKCalpha) acts upstream of PKCtheta to activate IkappaB kinase and NF-kappaB in T lymphocytes.
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Mol Cell Biol 23:7068-81 (2003)
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Regulation of Cdc2/cyclin B activation in Xenopus egg extracts via inhibitory phosphorylation of Cdc25C phosphatase by Ca(2+)/calmodulin-dependent protein [corrected] kinase II.
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Mol Biol Cell 14:4003-14 (2003)
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Reference
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Sphingosine 1-phosphate, sphingosine kinase and autocrine calcium signalling in thyroid cells.
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Acta Physiol (Oxf) 204:151-7 (2012)
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Reference
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Immunodeficiency due to defects in store-operated calcium entry.
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Ann N Y Acad Sci 1238:74-90 (2011)
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Reference
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Giachini FR, Lima VV, Hannan JL, Carneiro FS, Webb RC, Tostes RC
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STIM1/Orai1-mediated store-operated Ca2+ entry: the tip of the iceberg.
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Braz J Med Biol Res 44:1080-7 (2011)
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Reference
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Seikagaku 80:1123-8 (2008)
Reference
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Galione A, Evans AM, Ma J, Parrington J, Arredouani A, Cheng X, Zhu MX
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The acid test: the discovery of two-pore channels (TPCs) as NAADP-gated endolysosomal Ca(2+) release channels.
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Pflugers Arch 458:869-76 (2009)
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Reference
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Ca(2+) signaling in striated muscle: the elusive roles of triadin, junctin, and calsequestrin.
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Eur Biophys J 39:27-36 (2009)
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Reference
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Marty I
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Triadin regulation of the ryanodine receptor complex.
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J Physiol 593:3261-6 (2015)
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Reference
PMID:20807542
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Arvanitis DA, Vafiadaki E, Sanoudou D, Kranias EG
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Histidine-rich calcium binding protein: the new regulator of sarcoplasmic reticulum calcium cycling.
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J Mol Cell Cardiol 50:43-9 (2011)
DOI:10.1016/j.yjmcc.2010.08.021
Related
pathway
aamp04010  MAPK signaling pathway
aamp04070  Phosphatidylinositol signaling system
aamp04210  Apoptosis
aamp04720  Long-term potentiation
aamp04730  Long-term depression
KO pathway
ko04020   
LinkDB

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