KEGG   PATHWAY: ajm05160
Entry
ajm05160                    Pathway                                
Name
Hepatitis C - Artibeus jamaicensis (Jamaican fruit-eating bat)
Description
Hepatitis C virus (HCV) is a major cause of chronic liver disease. The HCV employ several strategies to perturb host cell immunity. After invasion, HCV RNA genome functions directly as an mRNA in the cytoplasm of the host cell and forms membrane-associated replication complexes along with non-structural proteins. Viral RNA can trigger the RIG-I pathway and interferon production during this process. Translated HCV protein products regulate immune response to inhibit the action of interferon. HCV core and NS5A proteins appear to be the most important molecules with regulatory functions that modulate transcription, cellular proliferation, and apoptosis.
Class
Human Diseases; Infectious disease: viral
Pathway map
ajm05160  Hepatitis C
ajm05160

Organism
Artibeus jamaicensis (Jamaican fruit-eating bat) [GN:ajm]
Gene
119038836  LDLR; low-density lipoprotein receptor [KO:K12473]
119060687  SCARB1; scavenger receptor class B member 1 isoform X1 [KO:K13885]
119057528  CD81; CD81 antigen [KO:K06508]
119054545  CLDN12; claudin-12 [KO:K06087]
119043453  CLDN11; claudin-11 [KO:K06087]
119035704  CLDN14; claudin-14 [KO:K06087]
119044714  CLDN15; claudin-15 isoform X1 [KO:K06087]
119044873  CLDN18; claudin-18 isoform X1 [KO:K06087]
119043593  CLDN2; claudin-2 [KO:K06087]
119036800  CLDN23; claudin-23 [KO:K06087]
119036844  claudin-22-like [KO:K06087]
119036914  putative claudin-24 [KO:K06087]
119037144  CLDN7; claudin-7 [KO:K06087]
119039096  CLDN1; claudin-1 [KO:K06087]
119039123  CLDN16; claudin-16 isoform X1 [KO:K06087]
119039687  CLDN10; claudin-10 isoform X1 [KO:K06087]
119034934  CLDN20; claudin-20 [KO:K06087]
119052477  CLDN19; claudin-19 [KO:K06087]
119053677  CLDN25; LOW QUALITY PROTEIN: putative claudin-25 [KO:K06087]
119061077  CLDN8; claudin-8 [KO:K06087]
119061088  CLDN17; claudin-17 [KO:K06087]
119046451  CLDN5; claudin-5 [KO:K06087]
119054898  claudin-23-like [KO:K06087]
119056253  CLDN6; claudin-6 [KO:K06087]
119056280  CLDN9; claudin-9 [KO:K06087]
119056363  CLDN4; claudin-4 [KO:K06087]
119056372  CLDN3; claudin-3 [KO:K06087]
119058383  CLDN34; claudin-34 [KO:K06087]
119044360  occludin-like [KO:K06088]
119040446  OAS3; 2'-5'-oligoadenylate synthase 3 isoform X1 [KO:K14216] [EC:2.7.7.84]
119040447  OAS1; 2'-5'-oligoadenylate synthase 1 [KO:K14216] [EC:2.7.7.84]
119040463  OAS2; LOW QUALITY PROTEIN: 2'-5'-oligoadenylate synthase 2 [KO:K14216] [EC:2.7.7.84]
119056133  2'-5'-oligoadenylate synthase 1-like [KO:K14216] [EC:2.7.7.84]
119049606  RNASEL; 2-5A-dependent ribonuclease isoform X1 [KO:K01165]
119060014  DDX58; antiviral innate immune response receptor RIG-I [KO:K12646] [EC:5.6.2.6]
119051154  MAVS; mitochondrial antiviral-signaling protein [KO:K12648]
119037870  TRAF3; TNF receptor-associated factor 3 isoform X1 [KO:K03174]
119045546  TBK1; serine/threonine-protein kinase TBK1 [KO:K05410] [EC:2.7.11.10]
119056820  IKBKE; inhibitor of nuclear factor kappa-B kinase subunit epsilon isoform X1 [KO:K07211] [EC:2.7.11.10]
119045996  IRF3; interferon regulatory factor 3 isoform X1 [KO:K05411]
119062180  IRF7; interferon regulatory factor 7 isoform X1 [KO:K09447]
119058844  interferon alpha-4-like [KO:K05414]
119045866  interferon alpha-7 [KO:K05414]
119045867  interferon alpha-4 [KO:K05414]
119056303  interferon alpha-4-like [KO:K05414]
119049818  interferon alpha-4-like [KO:K05414]
119055662  IFNB1; interferon beta [KO:K05415]
119042309  IFNG; interferon gamma [KO:K04687]
119036871  TLR3; toll-like receptor 3 [KO:K05401]
119063741  TICAM1; TIR domain-containing adapter molecule 1 [KO:K05842]
119036455  TRAF6; TNF receptor-associated factor 6 [KO:K03175] [EC:2.3.2.27]
119051788  RIPK1; receptor-interacting serine/threonine-protein kinase 1 isoform X1 [KO:K02861] [EC:2.7.11.1]
119064546  CHUK; inhibitor of nuclear factor kappa-B kinase subunit alpha [KO:K04467] [EC:2.7.11.10]
119047140  IKBKB; inhibitor of nuclear factor kappa-B kinase subunit beta isoform X1 [KO:K07209] [EC:2.7.11.10]
119053789  IKBKG; NF-kappa-B essential modulator isoform X1 [KO:K07210]
119062929  NFKBIA; NF-kappa-B inhibitor alpha [KO:K04734]
119057921  NFKB1; nuclear factor NF-kappa-B p105 subunit isoform X1 [KO:K02580]
119050282  RELA; transcription factor p65 [KO:K04735]
119053704  TNF; tumor necrosis factor isoform X1 [KO:K03156]
119052834  CXCL10; C-X-C motif chemokine 10 [KO:K12671]
119041501  EIF2AK1; eukaryotic translation initiation factor 2-alpha kinase 1 isoform X1 [KO:K16194] [EC:2.7.11.1]
119063844  EIF2AK2; interferon-induced, double-stranded RNA-activated protein kinase isoform X1 [KO:K16195] [EC:2.7.11.1]
119062169  EIF2AK3; eukaryotic translation initiation factor 2-alpha kinase 3 [KO:K08860] [EC:2.7.11.1]
119061226  EIF2AK4; eIF-2-alpha kinase GCN2 [KO:K16196] [EC:2.7.11.1]
119057768  interferon-induced protein with tetratricopeptide repeats 1-like [KO:K14217]
119065001  EIF3E; eukaryotic translation initiation factor 3 subunit E [KO:K03250]
119040976  eukaryotic translation initiation factor 2 subunit alpha [KO:K03237]
119034800  EIF2S1; eukaryotic translation initiation factor 2 subunit 1 [KO:K03237]
119052142  STAT3; signal transducer and activator of transcription 3 isoform X1 [KO:K04692]
119058654  SOCS3; suppressor of cytokine signaling 3 [KO:K04696]
119035720  IFNAR1; interferon alpha/beta receptor 1 [KO:K05130]
119035719  IFNAR2; interferon alpha/beta receptor 2 isoform X1 [KO:K05131]
119042494  JAK1; tyrosine-protein kinase JAK1 [KO:K11217] [EC:2.7.10.2]
119055683  non-receptor tyrosine-protein kinase TYK2-like [KO:K11219] [EC:2.7.10.2]
119062093  STAT1; signal transducer and activator of transcription 1-alpha/beta isoform X1 [KO:K11220]
119040310  STAT2; signal transducer and activator of transcription 2 [KO:K11221]
119037294  IRF9; interferon regulatory factor 9 [KO:K04693]
119048820  MX1; interferon-induced GTP-binding protein Mx1 [KO:K14754]
119048821  MX2; interferon-induced GTP-binding protein Mx2 [KO:K14754]
119053997  RSAD2; radical S-adenosyl methionine domain-containing protein 2 [KO:K15045]
119038446  PPP2R1A; serine/threonine-protein phosphatase 2A 65 kDa regulatory subunit A alpha isoform isoform X1 [KO:K03456]
119042443  PPP2R1B; serine/threonine-protein phosphatase 2A 65 kDa regulatory subunit A beta isoform isoform X1 [KO:K03456]
119061462  protein phosphatase PP2A regulatory subunit A-like [KO:K03456]
119049355  serine/threonine-protein phosphatase 2A 65 kDa regulatory subunit A beta isoform [KO:K03456]
119035534  PPP2R2C; protein phosphatase 2, regulatory subunit B, gamma [KO:K04354]
119044233  LOW QUALITY PROTEIN: serine/threonine-protein phosphatase 2A 55 kDa regulatory subunit B alpha isoform-like [KO:K04354]
119059476  PPP2R2D; serine/threonine-protein phosphatase 2A 55 kDa regulatory subunit B delta isoform [KO:K04354]
119053871  serine/threonine protein phosphatase 2A 55 kDa regulatory subunit B beta isoform [KO:K04354]
119061390  PPP2R2B; serine/threonine-protein phosphatase 2A 55 kDa regulatory subunit B beta isoform [KO:K04354]
119065166  PPP2R2A; serine/threonine-protein phosphatase 2A 55 kDa regulatory subunit B alpha isoform isoform X1 [KO:K04354]
119036814  PPP2CB; serine/threonine-protein phosphatase 2A catalytic subunit beta isoform [KO:K04382] [EC:3.1.3.16]
119053358  PPP2CA; serine/threonine-protein phosphatase 2A catalytic subunit alpha isoform [KO:K04382] [EC:3.1.3.16]
119056943  PIAS1; E3 SUMO-protein ligase PIAS1 isoform X1 [KO:K04706] [EC:2.3.2.-]
119057431  EGF; pro-epidermal growth factor isoform X1 [KO:K04357]
119057339  EGFR; epidermal growth factor receptor isoform X1 [KO:K04361] [EC:2.7.10.1]
119058521  GRB2; growth factor receptor-bound protein 2 [KO:K04364]
119052051  SOS1; son of sevenless homolog 1 isoform X1 [KO:K03099]
119056966  SOS2; son of sevenless homolog 2 [KO:K03099]
119062206  HRAS; GTPase HRas isoform X1 [KO:K02833]
119048987  KRAS; GTPase KRas isoform X1 [KO:K07827]
119041711  NRAS; GTPase NRas [KO:K07828]
119044502  BRAF; serine/threonine-protein kinase B-raf isoform X1 [KO:K04365] [EC:2.7.11.1]
119044815  RAF1; RAF proto-oncogene serine/threonine-protein kinase [KO:K04366] [EC:2.7.11.1]
119060144  ARAF; serine/threonine-protein kinase A-Raf isoform X1 [KO:K08845] [EC:2.7.11.1]
119040383  YWHAZ; 14-3-3 protein zeta/delta [KO:K16197]
119053996  YWHAQ; 14-3-3 protein theta [KO:K16197]
119063235  YWHAB; 14-3-3 protein beta/alpha [KO:K16197]
119040658  YWHAE; 14-3-3 protein epsilon [KO:K06630]
119059234  14-3-3-like protein B [KO:K06630]
119059235  14-3-3-like protein B [KO:K06630]
119047645  14-3-3-like protein GF14-A [KO:K06630]
119056042  14-3-3-like protein GF14-D [KO:K06630]
119044697  YWHAG; 14-3-3 protein gamma [KO:K16198]
119064910  YWHAH; 14-3-3 protein eta [KO:K16198]
119057101  MAP2K1; dual specificity mitogen-activated protein kinase kinase 1 [KO:K04368] [EC:2.7.12.2]
119063754  MAP2K2; dual specificity mitogen-activated protein kinase kinase 2 isoform X1 [KO:K04369] [EC:2.7.12.2]
119040930  MAPK3; mitogen-activated protein kinase 3 [KO:K04371] [EC:2.7.11.24]
119059157  MAPK1; mitogen-activated protein kinase 1 [KO:K04371] [EC:2.7.11.24]
119052227  phosphatidylinositol 3-kinase regulatory subunit gamma isoform X1 [KO:K02649]
119053288  PIK3R1; phosphatidylinositol 3-kinase regulatory subunit alpha isoform X1 [KO:K02649]
119046830  PIK3R2; phosphatidylinositol 3-kinase regulatory subunit beta [KO:K02649]
119043036  PIK3CA; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform [KO:K00922] [EC:2.7.1.153]
119044861  PIK3CB; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform isoform X1 [KO:K00922] [EC:2.7.1.153]
119064089  PIK3CD; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform isoform X1 [KO:K00922] [EC:2.7.1.153]
119040479  AKT2; RAC-beta serine/threonine-protein kinase [KO:K04456] [EC:2.7.11.1]
119053408  AKT3; RAC-gamma serine/threonine-protein kinase [KO:K04456] [EC:2.7.11.1]
119063115  AKT1; RAC-alpha serine/threonine-protein kinase [KO:K04456] [EC:2.7.11.1]
119059198  GSK3B; glycogen synthase kinase-3 beta isoform X1 [KO:K03083] [EC:2.7.11.26]
119051448  CTNNB1; catenin beta-1 [KO:K02105]
119045448  BAD; bcl2-associated agonist of cell death isoform X1 [KO:K02158]
119050063  CDKN1A; cyclin-dependent kinase inhibitor 1 [KO:K06625]
119059042  cellular tumor antigen p53-like [KO:K04451]
119053542  TP53; cellular tumor antigen p53 [KO:K04451]
119048545  CDK2; cyclin-dependent kinase 2 isoform X1 [KO:K02206] [EC:2.7.11.22]
119065244  CDK4; cyclin-dependent kinase 4 [KO:K02089] [EC:2.7.11.22]
119042716  CDK6; cyclin-dependent kinase 6 [KO:K02091] [EC:2.7.11.22]
119054193  RB1; retinoblastoma-associated protein isoform X1 [KO:K06618]
119047797  E2F1; transcription factor E2F1 [KO:K17454]
119042238  E2F2; transcription factor E2F2 isoform X1 [KO:K09389]
119055414  E2F3; transcription factor E2F3 isoform X1 [KO:K06620]
119060225  TNFRSF1A; tumor necrosis factor receptor superfamily member 1A isoform X1 [KO:K03158]
119061887  TRADD; tumor necrosis factor receptor type 1-associated DEATH domain protein isoform X1 [KO:K03171]
119036073  TRAF2; TNF receptor-associated factor 2 isoform X1 [KO:K03173] [EC:2.3.2.27]
119065454  FASLG; tumor necrosis factor ligand superfamily member 6 [KO:K04389]
119057762  FAS; tumor necrosis factor receptor superfamily member 6 [KO:K04390]
119041863  FADD; FAS-associated death domain protein [KO:K02373]
119065511  CASP8; caspase-8 [KO:K04398] [EC:3.4.22.61]
119036917  CASP3; caspase-3 [KO:K02187] [EC:3.4.22.56]
119047616  LOW QUALITY PROTEIN: CASP8 and FADD-like apoptosis regulator [KO:K04724]
119065514  CFLAR; LOW QUALITY PROTEIN: CASP8 and FADD-like apoptosis regulator [KO:K04724]
119044372  BID; BH3-interacting domain death agonist [KO:K04726]
119037607  BAX; apoptosis regulator BAX isoform X1 [KO:K02159]
119041220  BAK1; bcl-2 homologous antagonist/killer isoform X1 [KO:K14021]
119035254  cytochrome c [KO:K08738]
119035643  cytochrome c-like [KO:K08738]
119060513  APAF1; apoptotic protease-activating factor 1 isoform X1 [KO:K02084]
119049966  CASP9; caspase-9 [KO:K04399] [EC:3.4.22.62]
119051831  PSME3; proteasome activator complex subunit 3 [KO:K06698]
119036050  RXRA; retinoic acid receptor RXR-alpha isoform X1 [KO:K08524]
119060206  PPARA; peroxisome proliferator-activated receptor alpha [KO:K07294]
119064433  NR1H3; oxysterols receptor LXR-alpha isoform X1 [KO:K08536]
119041888  CCND1; G1/S-specific cyclin-D1 [KO:K04503]
119064823  MYC; myc proto-oncogene protein [KO:K04377]
Compound
C05981  Phosphatidylinositol-3,4,5-trisphosphate
C20935  2-5A
Reference
PMID:24520529
  Authors
Hassan M, Selimovic D, El-Khattouti A, Ghozlan H, Haikel Y, Abdelkader O
  Title
Hepatitis C virus-host interactions: Etiopathogenesis and therapeutic strategies.
  Journal
World J Exp Med 2:7-25 (2012)
DOI:10.5493/wjem.v2.i2.7
Reference
PMID:23641066
  Authors
Yamauchi Y, Helenius A
  Title
Virus entry at a glance.
  Journal
J Cell Sci 126:1289-95 (2013)
DOI:10.1242/jcs.119685
Reference
PMID:24509809
  Authors
Feneant L, Levy S, Cocquerel L
  Title
CD81 and hepatitis C virus (HCV) infection.
  Journal
Viruses 6:535-72 (2014)
DOI:10.3390/v6020535
Reference
PMID:18081727
  Authors
Dubuisson J, Helle F, Cocquerel L
  Title
Early steps of the hepatitis C virus life cycle.
  Journal
Cell Microbiol 10:821-7 (2008)
DOI:10.1111/j.1462-5822.2007.01107.x
Reference
PMID:23675659
  Authors
Liang TJ, Ghany MG
  Title
Current and future therapies for hepatitis C virus infection.
  Journal
N Engl J Med 368:1907-17 (2013)
DOI:10.1056/NEJMra1213651
Reference
PMID:23836234
  Authors
Scheel TK, Rice CM
  Title
Understanding the hepatitis C virus life cycle paves the way for highly effective therapies.
  Journal
Nat Med 19:837-49 (2013)
DOI:10.1038/nm.3248
Reference
PMID:26586968
  Authors
Holmes JA, Thompson AJ
  Title
Interferon-free combination therapies for the treatment of hepatitis C: current insights.
  Journal
Hepat Med 7:51-70 (2015)
DOI:10.2147/HMER.S55864
Reference
PMID:15039538
  Authors
Taguchi T, Nagano-Fujii M, Akutsu M, Kadoya H, Ohgimoto S, Ishido S, Hotta H
  Title
Hepatitis C virus NS5A protein interacts with 2',5'-oligoadenylate synthetase and inhibits antiviral activity of IFN in an IFN sensitivity-determining region-independent manner.
  Journal
J Gen Virol 85:959-69 (2004)
DOI:10.1099/vir.0.19513-0
Reference
PMID:19708811
  Authors
Horner SM, Gale M Jr
  Title
Intracellular innate immune cascades and interferon defenses that control hepatitis C virus.
  Journal
J Interferon Cytokine Res 29:489-98 (2009)
DOI:10.1089/jir.2009.0063
Reference
PMID:20457596
  Authors
Lemon SM
  Title
Induction and evasion of innate antiviral responses by hepatitis C virus.
  Journal
J Biol Chem 285:22741-7 (2010)
DOI:10.1074/jbc.R109.099556
Reference
PMID:23836238
  Authors
Horner SM, Gale M Jr
  Title
Regulation of hepatic innate immunity by hepatitis C virus.
  Journal
Nat Med 19:879-88 (2013)
DOI:10.1038/nm.3253
Reference
PMID:28862649
  Authors
Ortega-Prieto AM, Dorner M
  Title
Immune Evasion Strategies during Chronic Hepatitis B and C Virus Infection.
  Journal
Vaccines (Basel) 5:E24 (2017)
DOI:10.3390/vaccines5030024
Reference
PMID:25852264
  Authors
Yang DR, Zhu HZ
  Title
Hepatitis C virus and antiviral innate immunity: who wins at tug-of-war?
  Journal
World J Gastroenterol 21:3786-800 (2015)
DOI:10.3748/wjg.v21.i13.3786
Reference
PMID:16107833
  Authors
Gale M Jr, Foy EM
  Title
Evasion of intracellular host defence by hepatitis C virus.
  Journal
Nature 436:939-45 (2005)
DOI:10.1038/nature04078
Reference
PMID:17467654
  Authors
Bode JG, Brenndorfer ED, Haussinger D
  Title
Subversion of innate host antiviral strategies by the hepatitis C virus.
  Journal
Arch Biochem Biophys 462:254-65 (2007)
DOI:10.1016/j.abb.2007.03.033
Reference
PMID:12686421
  Authors
Panteva M, Korkaya H, Jameel S
  Title
Hepatitis viruses and the MAPK pathway: is this a survival strategy?
  Journal
Virus Res 92:131-40 (2003)
DOI:10.1016/S0168-1702(02)00356-8
Reference
PMID:16239065
  Authors
Pang R, Tse E, Poon RT
  Title
Molecular pathways in hepatocellular carcinoma.
  Journal
Cancer Lett 240:157-69 (2006)
DOI:10.1016/j.canlet.2005.08.031
Reference
PMID:15302943
  Authors
Macdonald A, Harris M
  Title
Hepatitis C virus NS5A: tales of a promiscuous protein.
  Journal
J Gen Virol 85:2485-502 (2004)
DOI:10.1099/vir.0.80204-0
Reference
PMID:21250384
  Authors
He Y, Staschke KA, Tan SL
  Title
HCV NS5A: A Multifunctional Regulator of Cellular Pathways and Virus Replication
  Journal
Hepatitis C Viruses: Genomes and Molecular Biology (2006)
Reference
PMID:12101418
  Authors
Lan KH, Sheu ML, Hwang SJ, Yen SH, Chen SY, Wu JC, Wang YJ, Kato N, Omata M, Chang FY, Lee SD
  Title
HCV NS5A interacts with p53 and inhibits p53-mediated apoptosis.
  Journal
Oncogene 21:4801-11 (2002)
DOI:10.1038/sj.onc.1205589
Reference
PMID:11886269
  Authors
Majumder M, Ghosh AK, Steele R, Zhou XY, Phillips NJ, Ray R, Ray RB
  Title
Hepatitis C virus NS5A protein impairs TNF-mediated hepatic apoptosis, but not by an anti-FAS antibody, in transgenic mice.
  Journal
Virology 294:94-105 (2002)
DOI:10.1006/viro.2001.1309
Reference
PMID:15381253
  Authors
Hassan M, Ghozlan H, Abdel-Kader O
  Title
Activation of RB/E2F signaling pathway is required for the modulation of hepatitis C virus core protein-induced cell growth in liver and non-liver cells.
  Journal
Cell Signal 16:1375-85 (2004)
DOI:10.1016/j.cellsig.2004.04.005
Reference
PMID:11514734
  Authors
Kwun HJ, Jung EY, Ahn JY, Lee MN, Jang KL
  Title
p53-dependent transcriptional repression of p21(waf1) by hepatitis C virus NS3.
  Journal
J Gen Virol 82:2235-41 (2001)
DOI:10.1099/0022-1317-82-9-2235
Reference
PMID:12056797
  Authors
Yamanaka T, Uchida M, Doi T
  Title
Innate form of HCV core protein plays an important role in the localization and the function of HCV core protein.
  Journal
Biochem Biophys Res Commun 294:521-7 (2002)
DOI:10.1016/S0006-291X(02)00507-7
Reference
PMID:22611309
  Authors
Lim EJ, Chin R, Angus PW, Torresi J
  Title
Enhanced apoptosis in post-liver transplant hepatitis C: effects of virus and immunosuppressants.
  Journal
World J Gastroenterol 18:2172-9 (2012)
DOI:10.3748/wjg.v18.i18.2172
Reference
PMID:17828818
  Authors
Fischer R, Baumert T, Blum HE
  Title
Hepatitis C virus infection and apoptosis.
  Journal
World J Gastroenterol 13:4865-72 (2007)
DOI:10.3748/wjg.v13.i36.4865
Reference
PMID:16611896
  Authors
Saito K, Meyer K, Warner R, Basu A, Ray RB, Ray R
  Title
Hepatitis C virus core protein inhibits tumor necrosis factor alpha-mediated apoptosis by a protective effect involving cellular FLICE inhibitory protein.
  Journal
J Virol 80:4372-9 (2006)
DOI:10.1128/JVI.80.9.4372-4379.2006
Reference
PMID:19148799
  Authors
Koike K
  Title
Steatosis, liver injury, and hepatocarcinogenesis in hepatitis C viral infection.
  Journal
J Gastroenterol 44 Suppl 19:82-8 (2009)
DOI:10.1007/s00535-008-2276-4
Reference
PMID:17764115
  Authors
Tanaka N, Moriya K, Kiyosawa K, Koike K, Aoyama T
  Title
Hepatitis C virus core protein induces spontaneous and persistent activation of peroxisome proliferator-activated receptor alpha in transgenic mice: implications for HCV-associated hepatocarcinogenesis.
  Journal
Int J Cancer 122:124-31 (2008)
DOI:10.1002/ijc.23056
Reference
PMID:18251977
  Authors
Tan A, Yeh SH, Liu CJ, Cheung C, Chen PJ
  Title
Viral hepatocarcinogenesis: from infection to cancer.
  Journal
Liver Int 28:175-88 (2008)
DOI:10.1111/j.1478-3231.2007.01652.x
Related
pathway
ajm03320  PPAR signaling pathway
ajm04010  MAPK signaling pathway
ajm04144  Endocytosis
ajm04210  Apoptosis
ajm04514  Cell adhesion molecules
ajm04620  Toll-like receptor signaling pathway
ajm04622  RIG-I-like receptor signaling pathway
ajm04630  JAK-STAT signaling pathway
ajm04668  TNF signaling pathway
KO pathway
ko05160   
LinkDB

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