KEGG   PATHWAY: csai04140
Entry
csai04140                   Pathway                                
Name
Autophagy - animal - Cololabis saira (Pacific saury)
Description
Autophagy (or macroautophagy) is a cellular catabolic pathway involving in protein degradation, organelle turnover, and non-selective breakdown of cytoplasmic components, which is evolutionarily conserved among eukaryotes and exquisitely regulated. This progress initiates with production of the autophagosome, a double-membrane intracellular structure of reticular origin that engulfs cytoplasmic contents and ultimately fuses with lysosomes for cargo degradation. Autophagy is regulated in response to extra- or intracellular stress and signals such as starvation, growth factor deprivation and ER stress. Constitutive level of autophagy plays an important role in cellular homeostasis and maintains quality control of essential cellular components.
Class
Cellular Processes; Transport and catabolism
Pathway map
csai04140  Autophagy - animal
csai04140

Other DBs
GO: 0006914
Organism
Cololabis saira (Pacific saury) [GN:csai]
Gene
133459997  ins; insulin [KO:K04526]
133447659  insulin-like [KO:K04526]
133460155  insulin-like [KO:K04526]
133464921  insulin-like growth factor 1 receptor [KO:K05087] [EC:2.7.10.1]
133444270  igf1ra; insulin-like growth factor 1a receptor [KO:K05087] [EC:2.7.10.1]
133459682  si:ch211-284e13.4; insulin receptor substrate 1-B [KO:K16172]
133419995  si:ch73-335l21.1; insulin receptor substrate 1-B [KO:K16172]
133445857  irs2b; insulin receptor substrate 2 [KO:K07187]
133425068  insulin receptor substrate 2-like isoform X1 [KO:K07187]
133420029  insulin receptor substrate 2-A [KO:K07187]
133458579  phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform-like [KO:K00922] [EC:2.7.1.153]
133453039  phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform [KO:K00922] [EC:2.7.1.153]
133420181  zgc:158659; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform [KO:K00922] [EC:2.7.1.153]
133441578  pik3cb; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform [KO:K00922] [EC:2.7.1.153]
133457284  pik3cd; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform [KO:K00922] [EC:2.7.1.153]
133457924  pik3r3b; phosphoinositide-3-kinase, regulatory subunit 3b (gamma) [KO:K02649]
133458551  phosphatidylinositol 3-kinase regulatory subunit gamma-like isoform X1 [KO:K02649]
133452923  pik3r2; phosphatidylinositol 3-kinase regulatory subunit beta [KO:K02649]
133453078  phosphatidylinositol 3-kinase regulatory subunit gamma-like isoform X1 [KO:K02649]
133455087  pik3r1; phosphatidylinositol 3-kinase regulatory subunit alpha [KO:K02649]
133451344  phosphatidylinositol 3-kinase regulatory subunit alpha-like [KO:K02649]
133418928  pdpk1b; 3-phosphoinositide-dependent protein kinase 1 [KO:K06276] [EC:2.7.11.1]
133464012  akt3a; RAC-gamma serine/threonine-protein kinase isoform X1 [KO:K04456] [EC:2.7.11.1]
133459420  RAC-beta serine/threonine-protein kinase-like [KO:K04456] [EC:2.7.11.1]
133446978  akt3b; RAC-gamma serine/threonine-protein kinase [KO:K04456] [EC:2.7.11.1]
133460147  RAC-beta serine/threonine-protein kinase-like [KO:K04456] [EC:2.7.11.1]
133441525  akt2; RAC-beta serine/threonine-protein kinase [KO:K04456] [EC:2.7.11.1]
133462884  akt1; RAC-alpha serine/threonine-protein kinase [KO:K04456] [EC:2.7.11.1]
133464057  phosphatidylinositol 3,4,5-trisphosphate 3-phosphatase and dual-specificity protein phosphatase PTEN isoform X1 [KO:K01110] [EC:3.1.3.16 3.1.3.48 3.1.3.67]
133418786  ptenb; phosphatidylinositol 3,4,5-trisphosphate 3-phosphatase and dual-specificity protein phosphatase PTEN [KO:K01110] [EC:3.1.3.16 3.1.3.48 3.1.3.67]
133444043  hrasa; HRas proto-oncogene, GTPase a [KO:K02833]
133444386  kras; GTPase KRas isoform X1 [KO:K07827]
133422137  zgc:55558; GTPase KRas [KO:K07827]
133446132  ras-related protein M-Ras [KO:K07831]
133461803  rras2; ras-related protein R-Ras2 [KO:K07830]
133422813  rras; ras-related protein R-Ras [KO:K07830]
133457013  raf1a; raf-1 proto-oncogene, serine/threonine kinase a isoform X1 [KO:K04366] [EC:2.7.11.1]
133444196  map2k1; dual specificity mitogen-activated protein kinase kinase 1 isoform X1 [KO:K04368] [EC:2.7.12.2]
133458123  map2k2a; dual specificity mitogen-activated protein kinase kinase 2a [KO:K04369] [EC:2.7.12.2]
133451560  mapk1; mitogen-activated protein kinase 1 [KO:K04371] [EC:2.7.11.24]
133422106  mapk3; mitogen-activated protein kinase 3 [KO:K04371] [EC:2.7.11.24]
133419632  epas1a; endothelial PAS domain-containing protein 1 [KO:K08268]
133441510  hif1al; hypoxia inducible factor 1 subunit alpha, like isoform X1 [KO:K08268]
133462011  hif1aa; hypoxia inducible factor 1 subunit alpha a [KO:K08268]
133418908  ddit4; DNA damage-inducible transcript 4 protein [KO:K08270]
133463488  DNA damage-inducible transcript 4 protein-like [KO:K08270]
133443224  tsc2; tuberin isoform X1 [KO:K07207]
133455417  tsc1b; TSC complex subunit 1b isoform X1 [KO:K07206]
133450761  hamartin-like isoform X1 [KO:K07206]
133464003  bnip4; BCL2 interacting protein 4 [KO:K15464]
133454564  zgc:73226; BCL2/adenovirus E1B 19 kDa protein-interacting protein 3 [KO:K15464]
133452445  GTP-binding protein Rheb [KO:K07208]
133448755  rhebl1; ras homolog, mTORC1 binding like 1 [KO:K07208]
133446846  rptor; regulatory-associated protein of mTOR isoform X1 [KO:K07204]
133427475  deptor; DEP domain-containing mTOR-interacting protein [KO:K20402]
133449584  si:dkeyp-97e7.9; DEP domain-containing mTOR-interacting protein [KO:K20402]
133457391  mtor; serine/threonine-protein kinase mTOR isoform X1 [KO:K07203] [EC:2.7.11.1]
133421507  akt1s1; uncharacterized protein akt1s1 isoform X1 [KO:K16184]
133418773  mlst8; target of rapamycin complex subunit lst8 [KO:K08266]
133459844  rps6kb1a; ribosomal protein S6 kinase beta-1 [KO:K04688] [EC:2.7.11.1]
133441625  rps6kb1b; ribosomal protein S6 kinase beta-1 isoform X1 [KO:K04688] [EC:2.7.11.1]
133449252  uncharacterized protein LOC133449252 [KO:K04688] [EC:2.7.11.1]
133447326  igbp1; immunoglobulin-binding protein 1 [KO:K17606]
133460036  ppp2cab; serine/threonine-protein phosphatase 2A catalytic subunit alpha isoform [KO:K04382] [EC:3.1.3.16]
133447350  serine/threonine-protein phosphatase 2A catalytic subunit alpha isoform-like [KO:K04382] [EC:3.1.3.16]
133451345  serine/threonine-protein phosphatase 2A catalytic subunit alpha isoform [KO:K04382] [EC:3.1.3.16]
133451572  serine/threonine-protein kinase ULK1-like [KO:K21357] [EC:2.7.11.1]
133455355  ulk1b; serine/threonine-protein kinase ULK1 isoform X1 [KO:K21357] [EC:2.7.11.1]
133441407  ulk2; serine/threonine-protein kinase ULK2 [KO:K08269] [EC:2.7.11.1]
133424950  atg13; autophagy-related protein 13 isoform X1 [KO:K08331]
133459856  atg101; autophagy-related protein 101 [KO:K19730]
133452823  rb1cc1; RB1-inducible coiled-coil protein 1 isoform X1 [KO:K17589]
133447110  atg2a; autophagy-related protein 2 homolog A [KO:K17906]
133461958  autophagy-related protein 2 homolog B-like [KO:K17906]
133419816  WD repeat domain phosphoinositide-interacting protein 1-like isoform X1 [KO:K17908]
133421802  wipi1; WD repeat domain phosphoinositide-interacting protein 1 isoform X1 [KO:K17908]
133422031  wipi2; WD repeat domain phosphoinositide-interacting protein 2 [KO:K17908]
133419071  wdr45b; WD repeat domain phosphoinositide-interacting protein 3 isoform X1 [KO:K22991]
133455167  wdr45; WD repeat domain phosphoinositide-interacting protein 4 isoform X1 [KO:K22991]
133452830  atg9b; autophagy-related protein 9B [KO:K17907]
133462317  atg9a; autophagy-related protein 9A [KO:K17907]
133459438  transcription factor SPT20 homolog isoform X1 [KO:K21245]
133459555  transcription factor SPT20 homolog isoform X1 [KO:K21245]
133441988  smcr8b; guanine nucleotide exchange protein smcr8b [KO:K23611]
133422120  smcr8a; guanine nucleotide exchange protein smcr8a [KO:K23611]
133454607  wdr41; WD repeat-containing protein 41 [KO:K23610]
133461975  c9orf72; guanine nucleotide exchange factor C9orf72 homolog [KO:K23609]
133458381  ras-related protein Rab-8A [KO:K07901]
133452430  ras-related protein Rab-8A-like [KO:K07901]
133459503  ras-related protein Rab-39B-like [KO:K07925]
133460565  rab42a; ras-related protein Rab-42a [KO:K07925]
133420342  rab39bb; RAB39B, member RAS oncogene family b [KO:K07925]
133447744  sqstm1; sequestosome-1 [KO:K14381]
133423903  tbk1; serine/threonine-protein kinase TBK1 isoform X1 [KO:K05410] [EC:2.7.11.10]
133445975  tank; TRAF family member-associated NF-kappa-B activator isoform X1 [KO:K12650]
133464148  ras-related protein ORAB-1-like isoform X1 [KO:K07874]
133446003  ras-related protein Rab-1A [KO:K07874]
133442027  ras-related protein Rab-1B-like [KO:K07874]
133460315  rraga; ras-related GTP-binding protein A [KO:K16185]
133460513  ras-related GTP-binding protein C-like [KO:K16186]
133437208  rragca; ras-related GTP binding Ca [KO:K16186]
133452638  stk11; serine/threonine-protein kinase STK11 [KO:K07298] [EC:2.7.11.1]
133458313  prkaa2; 5'-AMP-activated protein kinase catalytic subunit alpha-2 [KO:K07198] [EC:2.7.11.31]
133454998  prkaa1; 5'-AMP-activated protein kinase catalytic subunit alpha-1 [KO:K07198] [EC:2.7.11.31]
133458484  prkacba; protein kinase, cAMP-dependent, catalytic, beta a isoform X1 [KO:K04345] [EC:2.7.11.11]
133452802  prkacbb; protein kinase, cAMP-dependent, catalytic, beta b isoform X1 [KO:K04345] [EC:2.7.11.11]
133422677  prkacaa; protein kinase, cAMP-dependent, catalytic, alpha, genome duplicate a isoform X1 [KO:K04345] [EC:2.7.11.11]
133443811  cAMP-dependent protein kinase catalytic subunit alpha [KO:K04345] [EC:2.7.11.11]
133448765  prkcda; protein kinase C, delta a [KO:K06068] [EC:2.7.11.13]
133446927  mapk9; mitogen-activated protein kinase 9 [KO:K04440] [EC:2.7.11.24]
133419376  mapk8b; mitogen-activated protein kinase 8 isoform X1 [KO:K04440] [EC:2.7.11.24]
133454946  mapk10; mitogen-activated protein kinase 10 isoform X1 [KO:K04440] [EC:2.7.11.24]
133463188  mapk8a; mitogen-activated protein kinase 8 isoform X1 [KO:K04440] [EC:2.7.11.24]
133452737  bcl2b; apoptosis regulator Bcl-2 [KO:K02161]
133449583  bcl-2-like protein 1 [KO:K04570]
133456602  bcl2l1; bcl-2-like protein 1 [KO:K04570]
133420158  badb; BCL2 associated agonist of cell death b [KO:K02158]
133419770  becn1; beclin-1 [KO:K08334]
133440530  phosphoinositide 3-kinase regulatory subunit 4-like isoform X1 [KO:K08333] [EC:2.7.11.1]
133441201  LOW QUALITY PROTEIN: phosphoinositide 3-kinase regulatory subunit 4-like [KO:K08333] [EC:2.7.11.1]
133420304  pik3c3; phosphatidylinositol 3-kinase catalytic subunit type 3 isoform X1 [KO:K00914] [EC:2.7.1.137]
133461931  atg14; beclin 1-associated autophagy-related key regulator [KO:K17889]
133444077  ambra1b; activating molecule in BECN1-regulated autophagy protein 1B isoform X1 [KO:K17985]
133458825  traf6; TNF receptor-associated factor 6 [KO:K03175] [EC:2.3.2.27]
133457106  uncharacterized protein LOC133457106 isoform X1 [KO:K21247]
133460347  vacuole membrane protein 1-like [KO:K21248]
133441622  vmp1; vacuole membrane protein 1 [KO:K21248]
133430959  stx17; syntaxin-17 [KO:K08491]
133459861  uvrag; UV radiation resistance-associated gene protein [KO:K21249]
133462890  endophilin-B1-like [KO:K11248]
133423192  sh3glb1a; endophilin-B1a [KO:K11248]
133458506  rubcn; run domain Beclin-1-interacting and cysteine-rich domain-containing protein isoform X1 [KO:K19330]
133455344  calcium/calmodulin-dependent protein kinase kinase 2 isoform X1 [KO:K07359] [EC:2.7.11.17]
133418642  map3k7; mitogen-activated protein kinase kinase kinase 7 isoform X1 [KO:K04427] [EC:2.7.11.25]
133421926  serine/threonine-protein kinase/endoribonuclease IRE1-like isoform X1 [KO:K08852] [EC:2.7.11.1 3.1.26.-]
133441836  ern2; serine/threonine-protein kinase/endoribonuclease IRE1 isoform X1 [KO:K08852] [EC:2.7.11.1 3.1.26.-]
133448733  itpr1a; inositol 1,4,5-trisphosphate receptor type 1 isoform X1 [KO:K04958]
133448914  inositol 1,4,5-trisphosphate receptor type 1-like isoform X1 [KO:K04958]
133451503  dapk1; death-associated protein kinase 1 [KO:K08803] [EC:2.7.11.1]
133452566  dapk3; death-associated protein kinase 3 [KO:K08803] [EC:2.7.11.1]
133447413  death-associated protein kinase 3-like [KO:K08803] [EC:2.7.11.1]
133461202  si:dkey-240h12.4; death-associated protein kinase 2 [KO:K08803] [EC:2.7.11.1]
133444215  dapk2b; death-associated protein kinase 2 isoform X1 [KO:K08803] [EC:2.7.11.1]
133459457  hmgb1a; high mobility group protein B1a [KO:K10802]
133441912  hmgb1b; high mobility group protein B1b [KO:K10802]
133462047  eif2ak3; eukaryotic translation initiation factor 2-alpha kinase 3 [KO:K08860] [EC:2.7.11.1]
133461893  eif2ak4; eIF-2-alpha kinase GCN2 isoform X1 [KO:K16196] [EC:2.7.11.1]
133418577  eif2s1b; eukaryotic translation initiation factor 2 subunit 1b [KO:K03237]
133459818  mtmr4; myotubularin-related protein 4 isoform X1 [KO:K18082] [EC:3.1.3.48 3.1.3.64 3.1.3.95]
133451437  mtmr3; myotubularin-related protein 3 isoform X1 [KO:K18082] [EC:3.1.3.48 3.1.3.64 3.1.3.95]
133448966  mtmr14; myotubularin-related protein 14 [KO:K18086] [EC:3.1.3.64 3.1.3.95]
133418710  zfyve1; zinc finger FYVE domain-containing protein 1 isoform X1 [KO:K17603]
133441563  si:ch211-11n16.2; zinc finger FYVE domain-containing protein 1 [KO:K17603]
133462791  zinc finger FYVE domain-containing protein 1-like [KO:K17603]
133441045  atg12; ubiquitin-like protein ATG12 [KO:K08336]
133440335  atg5; autophagy protein 5 [KO:K08339]
133442061  atg16l1; autophagy-related protein 16-1 isoform X1 [KO:K17890]
133442103  protein Atg16l2-like isoform X1 [KO:K20868]
133448666  atg7; ubiquitin-like modifier-activating enzyme ATG7 [KO:K08337]
133424126  atg10; ubiquitin-like-conjugating enzyme ATG10 [KO:K17888]
133425262  atg3; ubiquitin-like-conjugating enzyme ATG3 [KO:K08343]
133446473  CASP8 and FADD-like apoptosis regulator isoform X1 [KO:K04724]
133447299  rab33ba; RAB33B, member RAS oncogene family a [KO:K07920]
133453416  ras-related protein Rab-33B-like [KO:K07920]
133423876  prkcq; protein kinase C theta type [KO:K18052] [EC:2.7.11.13]
133434362  zgc:92606; gamma-aminobutyric acid receptor-associated protein-like 1 [KO:K08341]
133420093  gabarapa; GABA(A) receptor-associated protein a [KO:K08341]
133443914  gabarapl2; gamma-aminobutyric acid receptor-associated protein-like 2 [KO:K08341]
133446126  map1lc3c; microtubule-associated proteins 1A/1B light chain 3C [KO:K10435]
133447593  map1lc3cl; microtubule-associated proteins 1A/1B light chain 3C [KO:K10435]
133449202  map1lc3a; microtubule-associated proteins 1A/1B light chain 3A [KO:K10435]
133443856  map1lc3b; microtubule-associated proteins 1A/1B light chain 3B [KO:K10435]
133458055  atg4b; cysteine protease ATG4B [KO:K08342] [EC:3.4.22.-]
133458613  atg4c; cysteine protease ATG4C isoform X1 [KO:K08342] [EC:3.4.22.-]
133429386  atg4da; cysteine protease atg4da [KO:K08342] [EC:3.4.22.-]
133422404  cysteine protease atg4da [KO:K08342] [EC:3.4.22.-]
133419695  next to BRCA1 gene 1 protein-like isoform X1 [KO:K17987]
133422157  nbr1b; next to BRCA1 gene 1 protein isoform X1 [KO:K17987]
133423948  optn; optineurin [KO:K19946]
133418757  calcoco2; calcium-binding and coiled-coil domain-containing protein 2 [KO:K21348]
133429874  tax1bp1b; tax1-binding protein 1 homolog B isoform X1 [KO:K21347]
133461636  tax1bp1a; tax1-binding protein 1 homolog A isoform X1 [KO:K21347]
133451544  wdfy3; WD repeat and FYVE domain-containing protein 3 isoform X1 [KO:K22262]
133458563  uba52; ubiquitin-60S ribosomal protein L40 [KO:K02927]
133463736  rps27a; ubiquitin-40S ribosomal protein S27a [KO:K02977]
133451124  snap29; synaptosomal-associated protein 29 [KO:K08509]
133455050  vesicle-associated membrane protein 8-like isoform X1 [KO:K08512]
133455053  vesicle-associated membrane protein 8-like isoform X1 [KO:K08512]
133451445  vamp8; vesicle-associated membrane protein 8 [KO:K08512]
133450700  ykt6; synaptobrevin homolog YKT6 [KO:K08516]
133418403  stx7l; syntaxin-7 [KO:K08488]
133450438  epg5; ectopic P granules protein 5 homolog [KO:K23883]
133419008  plekhm1; pleckstrin homology domain-containing family M member 1 [KO:K23282]
133459885  vps11; vacuolar protein sorting-associated protein 11 homolog [KO:K20179]
133425378  vps16; vacuolar protein sorting-associated protein 16 homolog isoform X1 [KO:K20180]
133418365  vps18; vacuolar protein sorting-associated protein 18 homolog [KO:K20181]
133451010  vps33a; vacuolar protein sorting-associated protein 33A [KO:K20182]
133461904  vps39; vam6/Vps39-like protein [KO:K20183]
133422918  vps41; vacuolar protein sorting-associated protein 41 homolog [KO:K20184]
133463533  birc6; baculoviral IAP repeat-containing protein 6 isoform X1 [KO:K10586] [EC:2.3.2.23]
133445948  Golgi reassembly-stacking protein 2-like [KO:K26797]
133453124  Golgi reassembly-stacking protein 2-like [KO:K26797]
133453153  gorasp1a; Golgi reassembly-stacking protein 1a isoform X1 [KO:K26797]
133423101  Golgi reassembly-stacking protein 1-like isoform X1 [KO:K26797]
133448771  rab7a; ras-related protein Rab-7a [KO:K07897]
133446545  lamp1b; lysosome-associated membrane glycoprotein 1b [KO:K06528]
133447170  lamp2; lysosome-associated membrane glycoprotein 2 isoform X1 [KO:K06528]
133460734  lamp1a; lysosome-associated membrane glycoprotein 1a [KO:K06528]
133458636  ctsd; cathepsin D [KO:K01379] [EC:3.4.23.5]
133422478  napsa; napsin-A [KO:K01379] [EC:3.4.23.5]
133451504  ctsla; cathepsin La [KO:K01365] [EC:3.4.22.15]
133458291  cts12; procathepsin L [KO:K01365] [EC:3.4.22.15]
133461964  ctsl.1; cathepsin L.1 [KO:K01365] [EC:3.4.22.15]
133463675  ctsba; cathepsin B [KO:K01363] [EC:3.4.22.1]
133418479  cathepsin B-like [KO:K01363] [EC:3.4.22.1]
Compound
C00035  GDP
C00044  GTP
C00350  Phosphatidylethanolamine
C01194  1-Phosphatidyl-D-myo-inositol
C04549  1-Phosphatidyl-1D-myo-inositol 3-phosphate
C05981  Phosphatidylinositol-3,4,5-trisphosphate
Reference
PMID:15325584
  Authors
Meijer AJ, Codogno P.
  Title
Regulation and role of autophagy in mammalian cells.
  Journal
Int J Biochem Cell Biol 36:2445-62 (2004)
DOI:10.1016/j.biocel.2004.02.002
Reference
PMID:16099218
  Authors
Deretic V.
  Title
Autophagy in innate and adaptive immunity.
  Journal
Trends Immunol 26:523-8 (2005)
DOI:10.1016/j.it.2005.08.003
Reference
PMID:16200202
  Authors
Levine B, Yuan J.
  Title
Autophagy in cell death: an innocent convict?
  Journal
J Clin Invest 115:2679-88 (2005)
DOI:10.1172/JCI26390
Reference
PMID:15325588
  Authors
Tanida I, Ueno T, Kominami E.
  Title
LC3 conjugation system in mammalian autophagy.
  Journal
Int J Biochem Cell Biol 36:2503-18 (2004)
DOI:10.1016/j.biocel.2004.05.009
Reference
PMID:15928708
  Authors
Lum JJ, DeBerardinis RJ, Thompson CB.
  Title
Autophagy in metazoans: cell survival in the land of plenty.
  Journal
Nat Rev Mol Cell Biol 6:439-48 (2005)
DOI:10.1038/nrm1660
Reference
PMID:15978794
  Authors
Reggiori F, Klionsky DJ.
  Title
Autophagosomes: biogenesis from scratch?
  Journal
Curr Opin Cell Biol 17:415-22 (2005)
DOI:10.1016/j.ceb.2005.06.007
Reference
PMID:11099404
  Authors
Klionsky DJ, Emr SD.
  Title
Autophagy as a regulated pathway of cellular degradation.
  Journal
Science 290:1717-21 (2000)
DOI:10.1126/science.290.5497.1717
Reference
PMID:16125113
  Authors
Bechet D, Tassa A, Taillandier D, Combaret L, Attaix D.
  Title
Lysosomal proteolysis in skeletal muscle.
  Journal
Int J Biochem Cell Biol 37:2098-114 (2005)
DOI:10.1016/j.biocel.2005.02.029
Reference
PMID:19653858
  Authors
He C, Klionsky DJ
  Title
Regulation mechanisms and signaling pathways of autophagy.
  Journal
Annu Rev Genet 43:67-93 (2009)
DOI:10.1146/annurev-genet-102808-114910
Reference
PMID:19802558
  Authors
Yang Z, Klionsky DJ
  Title
An overview of the molecular mechanism of autophagy.
  Journal
Curr Top Microbiol Immunol 335:1-32 (2009)
DOI:10.1007/978-3-642-00302-8_1
Reference
PMID:20034776
  Authors
Yang Z, Klionsky DJ
  Title
Mammalian autophagy: core molecular machinery and signaling regulation.
  Journal
Curr Opin Cell Biol 22:124-31 (2010)
DOI:10.1016/j.ceb.2009.11.014
Reference
PMID:21187343
  Authors
Chen Y, Klionsky DJ
  Title
The regulation of autophagy - unanswered questions.
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J Cell Sci 124:161-70 (2011)
DOI:10.1242/jcs.064576
Reference
PMID:21801009
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Mizushima N, Yoshimori T, Ohsumi Y
  Title
The role of Atg proteins in autophagosome formation.
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Annu Rev Cell Dev Biol 27:107-32 (2011)
DOI:10.1146/annurev-cellbio-092910-154005
Reference
PMID:24343578
  Authors
Russell RC, Yuan HX, Guan KL
  Title
Autophagy regulation by nutrient signaling.
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Cell Res 24:42-57 (2014)
DOI:10.1038/cr.2013.166
Reference
PMID:25948417
  Authors
Noda NN, Fujioka Y
  Title
Atg1 family kinases in autophagy initiation.
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Cell Mol Life Sci 72:3083-96 (2015)
DOI:10.1007/s00018-015-1917-z
Related
pathway
csai04010  MAPK signaling pathway
csai04141  Protein processing in endoplasmic reticulum
csai04142  Lysosome
csai04150  mTOR signaling pathway
csai04910  Insulin signaling pathway
KO pathway
ko04140   
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