KEGG   PATHWAY: emac04510
Entry
emac04510                   Pathway                                
Name
Focal adhesion - Eleginops maclovinus (Patagonian blennie)
Description
Cell-matrix adhesions play essential roles in important biological processes including cell motility, cell proliferation, cell differentiation, regulation of gene expression and cell survival. At the cell-extracellular matrix contact points, specialized structures are formed and termed focal adhesions, where bundles of actin filaments are anchored to transmembrane receptors of the integrin family through a multi-molecular complex of junctional plaque proteins. Some of the constituents of focal adhesions participate in the structural link between membrane receptors and the actin cytoskeleton, while others are signalling molecules, including different protein kinases and phosphatases, their substrates, and various adapter proteins. Integrin signaling is dependent upon the non-receptor tyrosine kinase activities of the FAK and src proteins as well as the adaptor protein functions of FAK, src and Shc to initiate downstream signaling events. These signalling events culminate in reorganization of the actin cytoskeleton; a prerequisite for changes in cell shape and motility, and gene expression. Similar morphological alterations and modulation of gene expression are initiated by the binding of growth factors to their respective receptors, emphasizing the considerable crosstalk between adhesion- and growth factor-mediated signalling.
Class
Cellular Processes; Cellular community - eukaryotes
Pathway map
emac04510  Focal adhesion
emac04510

Other DBs
GO: 0005925
Organism
Eleginops maclovinus (Patagonian blennie) [GN:emac]
Gene
134870754  col1a1b; collagen, type I, alpha 1b [KO:K06236]
134877997  col1a1a; collagen, type I, alpha 1a [KO:K06236]
134874809  col1a2; collagen alpha-2(I) chain [KO:K06236]
134862599  col2a1a; collagen, type II, alpha 1a [KO:K19719]
134882866  col2a1b; LOW QUALITY PROTEIN: collagen, type II, alpha 1b [KO:K19719]
134866017  collagen alpha-4(IV) chain-like [KO:K06237]
134866018  collagen alpha-3(IV) chain-like [KO:K06237]
134867465  col4a2; collagen alpha-2(IV) chain isoform X1 [KO:K06237]
134867466  col4a1; LOW QUALITY PROTEIN: collagen alpha-1(IV) chain [KO:K06237]
134880605  col4a4; LOW QUALITY PROTEIN: collagen alpha-4(IV) chain [KO:K06237]
134880673  col4a3; collagen alpha-5(IV) chain [KO:K06237]
134875919  col4a6; LOW QUALITY PROTEIN: collagen alpha-6(IV) chain [KO:K06237]
134875928  col4a5; collagen alpha-5(IV) chain isoform X1 [KO:K06237]
134865978  col6a1; collagen alpha-1(VI) chain [KO:K06238]
134866141  col6a2; collagen alpha-2(VI) chain isoform X1 [KO:K06238]
134866941  collagen alpha-3(VI) chain [KO:K06238]
134867046  col6a3; collagen alpha-3(VI) chain isoform X1 [KO:K06238]
134867301  collagen alpha-2(VI) chain-like isoform X1 [KO:K06238]
134862233  collagen alpha-6(VI) chain-like isoform X1 [KO:K06238]
134862234  collagen alpha-6(VI) chain-like [KO:K06238]
134858382  col9a1b; collagen, type IX, alpha 1b [KO:K08131]
134864924  col9a1a; LOW QUALITY PROTEIN: collagen, type IX, alpha 1a [KO:K08131]
134867743  col9a3; collagen alpha-3(IX) chain isoform X1 [KO:K08131]
134875217  collagen alpha-3(IX) chain-like [KO:K08131]
134875445  col9a2; collagen alpha-2(IX) chain [KO:K08131]
134884075  lama1; LOW QUALITY PROTEIN: laminin subunit alpha-1 [KO:K05637]
134876839  lama2; LOW QUALITY PROTEIN: laminin subunit alpha-2 [KO:K05637]
134869369  LOW QUALITY PROTEIN: laminin subunit alpha-5-like [KO:K06240]
134865960  laminin subunit alpha-3-like [KO:K06240]
134877271  lama4; LOW QUALITY PROTEIN: laminin subunit alpha-4 [KO:K06241]
134879191  lamb1b; LOW QUALITY PROTEIN: laminin subunit beta-1b [KO:K05636]
134867262  lamb2l; LOW QUALITY PROTEIN: laminin subunit beta-2 [KO:K06243]
134867267  lamb2; laminin subunit beta-2 [KO:K06243]
134883033  laminin subunit beta-3-like [KO:K06244]
134881377  lamb4; LOW QUALITY PROTEIN: laminin subunit beta-4 [KO:K06245]
134866008  lamc1; LOW QUALITY PROTEIN: laminin subunit gamma-1 [KO:K05635]
134866552  lamc2; laminin subunit gamma-2 [KO:K06246]
134868005  lamc3; laminin subunit gamma-3 [KO:K06247]
134870621  chad; chondroadherin [KO:K06248]
134875051  reln; LOW QUALITY PROTEIN: reelin [KO:K06249] [EC:3.4.21.-]
134881352  LOW QUALITY PROTEIN: thrombospondin-1-like [KO:K16857]
134876790  thbs1b; thrombospondin-1 [KO:K16857]
134869377  comp; cartilage oligomeric matrix protein [KO:K04659]
134858719  thbs2a; thrombospondin-2 isoform X1 [KO:K04659]
134870778  thrombospondin-2-like isoform X1 [KO:K04659]
134862718  thbs3a; thrombospondin-3a isoform X1 [KO:K04659]
134868260  thbs4b; thrombospondin-4-B isoform X1 [KO:K04659]
134873509  thbs4a; LOW QUALITY PROTEIN: thrombospondin-4a [KO:K04659]
134867286  fn1a; fibronectin 1a isoform X1 [KO:K05717]
134871655  vtnb; LOW QUALITY PROTEIN: vitronectin b [KO:K06251]
134879992  vtna; vitronectin a [KO:K06251]
134868824  tenascin-like isoform X1 [KO:K06252]
134865480  tnr; tenascin-R isoform X1 [KO:K06252]
134861482  tnxba; tenascin [KO:K06252]
134866567  tnn; tenascin-N isoform X1 [KO:K06252]
134873222  tncb; tenascin isoform X1 [KO:K06252]
134875149  tenascin-X [KO:K06252]
134883130  vwf; von Willebrand factor [KO:K03900]
134868659  itga1; integrin alpha-1 [KO:K06480]
134873787  itga2.2; integrin alpha-2 [KO:K06481]
134870694  itga3b; integrin alpha-3b [KO:K06482]
134878675  integrin alpha-3-like isoform X1 [KO:K06482]
134866989  itga4; integrin alpha-4 [KO:K06483]
134866616  itga5; LOW QUALITY PROTEIN: integrin alpha-5 [KO:K06484]
134883507  integrin alpha-5-like [KO:K06484]
134859525  integrin alpha-6-like isoform X1 [KO:K06485]
134865859  integrin alpha-6-like isoform X1 [KO:K06485]
134867106  itga6a; integrin alpha-6 isoform X1 [KO:K06485]
134883382  itga7; integrin alpha-7 isoform X1 [KO:K06583]
134861882  itga8; integrin alpha-8 [KO:K06584]
134858880  itga9; integrin alpha-9 [KO:K06585]
134861402  itga10; integrin alpha-10 [KO:K06586]
134862578  itga11a; integrin alpha-11a isoform X1 [KO:K06587]
134879491  itga11b; LOW QUALITY PROTEIN: integrin alpha-11 [KO:K06587]
134866975  itgav; integrin alpha-V [KO:K06487]
134862203  integrin beta-1-like [KO:K05719]
134884099  itgb1a; integrin beta-1a isoform X1 [KO:K05719]
134870984  LOW QUALITY PROTEIN: integrin beta-3-like [KO:K06493]
134878052  itgb3a; integrin beta-3a isoform X1 [KO:K06493]
134870728  itgb4; LOW QUALITY PROTEIN: integrin beta-4 [KO:K06525]
134867238  itgb5; integrin beta-5 [KO:K06588]
134862992  itgb6; integrin beta-6 [KO:K06589]
134875413  itgb8; LOW QUALITY PROTEIN: integrin beta-8 [KO:K06591]
134878652  emp2; epithelial membrane protein 2 [KO:K26256]
134862786  platelet-derived growth factor subunit A-like [KO:K04359]
134878479  pdgfab; platelet-derived growth factor alpha polypeptide b [KO:K04359]
134862759  pdgfba; platelet-derived growth factor beta polypeptide a [KO:K17386]
134860056  pdgfc; platelet-derived growth factor C isoform X1 [KO:K05450]
134879772  pdgfd; platelet-derived growth factor D isoform X1 [KO:K05450]
134859778  egf; pro-epidermal growth factor [KO:K04357]
134879206  igf1; insulin-like growth factor I [KO:K05459]
134881571  igf3; insulin-like growth factor 3 isoform X1 [KO:K05459]
134860065  vegfba; vascular endothelial growth factor A isoform X1 [KO:K05448]
134861840  vegfaa; vascular endothelial growth factor A-A isoform X1 [KO:K05448]
134876513  vegfab; vascular endothelial growth factor Ab isoform X1 [KO:K05448]
134882072  pgfb; placenta growth factor [KO:K16859]
134876589  LOW QUALITY PROTEIN: vascular endothelial growth factor A-like [KO:K16859]
134863469  vegfd; vascular endothelial growth factor D [KO:K05449]
134864906  vegfc; vascular endothelial growth factor C [KO:K05449]
134860614  vascular endothelial growth factor C-like isoform X1 [KO:K05449]
134858429  hgfb; hepatocyte growth factor [KO:K05460]
134878889  hgfa; hepatocyte growth factor a isoform X1 [KO:K05460]
134869964  pdgfra; LOW QUALITY PROTEIN: platelet-derived growth factor receptor alpha [KO:K04363] [EC:2.7.10.1]
134859941  pdgfrb; platelet-derived growth factor receptor beta [KO:K05089] [EC:2.7.10.1]
134872060  platelet-derived growth factor receptor beta-like isoform X1 [KO:K05089] [EC:2.7.10.1]
134863593  igf1rb; insulin-like growth factor 1b receptor isoform X1 [KO:K05087] [EC:2.7.10.1]
134876718  igf1ra; LOW QUALITY PROTEIN: insulin-like growth factor 1a receptor [KO:K05087] [EC:2.7.10.1]
134870103  kdr; vascular endothelial growth factor receptor 2 isoform X1 [KO:K05098] [EC:2.7.10.1]
134865705  egfra; epidermal growth factor receptor [KO:K04361] [EC:2.7.10.1]
134884092  melanoma receptor tyrosine-protein kinase-like isoform X1 [KO:K04361] [EC:2.7.10.1]
134857992  flt1; vascular endothelial growth factor receptor 1 isoform X1 [KO:K05096] [EC:2.7.10.1]
134859714  kdrl; vascular endothelial growth factor receptor kdr-like [KO:K05096] [EC:2.7.10.1]
134859362  flt4; vascular endothelial growth factor receptor 3 isoform X1 [KO:K05097] [EC:2.7.10.1]
134883948  met; hepatocyte growth factor receptor isoform X1 [KO:K05099] [EC:2.7.10.1]
134870530  erbb2; LOW QUALITY PROTEIN: receptor tyrosine-protein kinase erbB-2 [KO:K05083] [EC:2.7.10.1]
134864419  emp1; epithelial membrane protein 1 [KO:K26255]
134878471  epithelial membrane protein 2-like [KO:K26255]
134863476  src; proto-oncogene tyrosine-protein kinase Src isoform X1 [KO:K05704] [EC:2.7.10.2]
134882771  proto-oncogene tyrosine-protein kinase Src-like isoform X1 [KO:K05704] [EC:2.7.10.2]
134871749  arhgap35b; rho GTPase-activating protein 35 [KO:K05732]
134880144  arhgap35a; rho GTPase-activating protein 35 [KO:K05732]
134881557  arhgap5; rho GTPase-activating protein 5 [KO:K13709]
134869584  rho-related GTP-binding protein RhoA-D-like [KO:K04513]
134869593  rho-related GTP-binding protein RhoA-C-like [KO:K04513]
134866513  rho-related GTP-binding protein RhoA-C-like [KO:K04513]
134883347  rhoab; rho-related GTP-binding protein RhoA-B [KO:K04513]
134882594  transforming protein RhoA [KO:K04513]
134860124  LOW QUALITY PROTEIN: protein diaphanous homolog 1 [KO:K05740]
134866068  rock1; rho-associated protein kinase 1 isoform X1 [KO:K04514] [EC:2.7.11.1]
134881487  rock2a; LOW QUALITY PROTEIN: rho-associated protein kinase 2 [KO:K17388] [EC:2.7.11.1]
134876738  rho-associated protein kinase 2-like isoform X1 [KO:K17388] [EC:2.7.11.1]
134873754  myl2b; myosin, light chain 2b, regulatory, cardiac, slow [KO:K10351]
134882188  myl2a; myosin regulatory light chain 2a [KO:K10351]
134873293  myl7; myosin regulatory light chain 2, atrial isoform [KO:K12754]
134882805  myl9b; myosin regulatory light polypeptide 9b [KO:K12755]
134866040  myl12.2; myosin, light chain 12, genome duplicate 2 isoform X1 [KO:K12757]
134884021  myl12.1; myosin, light chain 12, genome duplicate 1 [KO:K12757]
134870641  mylpfb; myosin regulatory light chain 2, skeletal muscle [KO:K12758]
134877747  mylpfa; myosin regulatory light chain 2, skeletal muscle [KO:K12758]
134870589  serine/threonine-protein phosphatase alpha-2 isoform-like [KO:K06269] [EC:3.1.3.16]
134877778  ppp1caa; protein phosphatase 1, catalytic subunit, alpha isozyme a [KO:K06269] [EC:3.1.3.16]
134873899  ppp1cc; serine/threonine-protein phosphatase PP1-gamma catalytic subunit A isoform X1 [KO:K06269] [EC:3.1.3.16]
134875912  serine/threonine-protein phosphatase PP1-beta catalytic subunit [KO:K06269] [EC:3.1.3.16]
134881896  serine/threonine-protein phosphatase PP1-beta catalytic subunit-like [KO:K06269] [EC:3.1.3.16]
134876668  serine/threonine-protein phosphatase PP1-beta catalytic subunit-like [KO:K06269] [EC:3.1.3.16]
134879172  ppp1r12a; LOW QUALITY PROTEIN: protein phosphatase 1 regulatory subunit 12A [KO:K06270]
134870254  protein phosphatase 1 regulatory subunit 12B-like isoform X1 [KO:K12329]
134864362  ppp1r12c; protein phosphatase 1 regulatory subunit 12C isoform X1 [KO:K17457]
134876010  zmp:0000001167; protein phosphatase 1 regulatory subunit 12A isoform X1 [KO:K17457]
134866496  mylk4a; myosin light chain kinase 3 isoform X1 [KO:K00907] [EC:2.7.11.18]
134870108  mylk4b; myosin light chain kinase 2, skeletal/cardiac muscle isoform X1 [KO:K00907] [EC:2.7.11.18]
134870831  myosin light chain kinase, smooth muscle-like isoform X1 [KO:K00907] [EC:2.7.11.18]
134867355  LOW QUALITY PROTEIN: myosin light chain kinase, smooth muscle-like [KO:K00907] [EC:2.7.11.18]
134878480  mylk5; myosin light chain kinase, smooth muscle isoform X1 [KO:K00907] [EC:2.7.11.18]
134868473  pip5k1ba; phosphatidylinositol-4-phosphate 5-kinase, type I, beta a isoform X1 [KO:K00889] [EC:2.7.1.68]
134869264  pip5k1ca; phosphatidylinositol 4-phosphate 5-kinase type-1 gamma isoform X1 [KO:K00889] [EC:2.7.1.68]
134865873  phosphatidylinositol 4-phosphate 5-kinase type-1 gamma-like isoform X1 [KO:K00889] [EC:2.7.1.68]
134861735  phosphatidylinositol 4-phosphate 5-kinase type-1 alpha-like isoform X1 [KO:K00889] [EC:2.7.1.68]
134873182  pip5k1bb; phosphatidylinositol 4-phosphate 5-kinase type-1 beta [KO:K00889] [EC:2.7.1.68]
134875414  phosphatidylinositol 4-phosphate 5-kinase type-1 alpha-like isoform X1 [KO:K00889] [EC:2.7.1.68]
134864678  actb1; actin, cytoplasmic 1 [KO:K05692]
134877656  actb2; actin, cytoplasmic 2 [KO:K05692]
134863793  LOW QUALITY PROTEIN: ras-specific guanine nucleotide-releasing factor 1-like [KO:K04349]
134859092  rasgrf1; LOW QUALITY PROTEIN: ras-specific guanine nucleotide-releasing factor 1 [KO:K04349]
134863186  calpain-2 catalytic subunit-like isoform X1 [KO:K03853] [EC:3.4.22.53]
134858433  capn8; calpain-8 isoform X1 [KO:K03853] [EC:3.4.22.53]
134858435  calpain-2 catalytic subunit-like [KO:K03853] [EC:3.4.22.53]
134862697  calpain-2 catalytic subunit-like [KO:K03853] [EC:3.4.22.53]
134862887  calpain-2 catalytic subunit-like [KO:K03853] [EC:3.4.22.53]
134880737  actn4; alpha-actinin-4 isoform X1 [KO:K05699]
134881443  actn1; alpha-actinin-1 isoform X1 [KO:K05699]
134863478  tln2a; LOW QUALITY PROTEIN: talin-2a [KO:K06271]
134868375  tln1; talin-1 [KO:K06271]
134884088  tln2b; talin-2 [KO:K06271]
134861533  flna; filamin-A isoform X1 [KO:K04437]
134882338  LOW QUALITY PROTEIN: filamin-B-like [KO:K27392]
134873687  mucin-2-like [KO:K05760]
134882834  paxillin-like isoform X1 [KO:K05760]
134872604  ilk; integrin-linked protein kinase [KO:K06272] [EC:2.7.11.1]
134879980  integrin-linked protein kinase [KO:K06272] [EC:2.7.11.1]
134861250  zyx; zyxin [KO:K06273]
134871797  vasodilator-stimulated phosphoprotein-like isoform X1 [KO:K06274]
134880201  vaspb; vasodilator-stimulated phosphoprotein isoform X1 [KO:K06274]
134858467  vinculin-like isoform X1 [KO:K05700]
134870634  LOW QUALITY PROTEIN: vinculin-like [KO:K05700]
134881814  parvb; beta-parvin isoform X1 [KO:K06275]
134882595  parvaa; parvin, alpha a [KO:K06275]
134882603  parvg; LOW QUALITY PROTEIN: gamma-parvin [KO:K06275]
134870788  pdpk1b; 3-phosphoinositide-dependent protein kinase 1 [KO:K06276] [EC:2.7.11.1]
134865040  akt3b; RAC-gamma serine/threonine-protein kinase [KO:K04456] [EC:2.7.11.1]
134871875  RAC-beta serine/threonine-protein kinase-like [KO:K04456] [EC:2.7.11.1]
134871879  RAC-beta serine/threonine-protein kinase-like [KO:K04456] [EC:2.7.11.1]
134880032  akt2; RAC-beta serine/threonine-protein kinase [KO:K04456] [EC:2.7.11.1]
134881467  akt1; RAC-alpha serine/threonine-protein kinase [KO:K04456] [EC:2.7.11.1]
134866892  gsk3ba; glycogen synthase kinase-3 beta isoform X1 [KO:K03083] [EC:2.7.11.26]
134861846  ctnnb1; catenin beta-1 [KO:K02105]
134874879  catenin beta-1-like [KO:K02105]
134865204  prkcaa; protein kinase C, alpha, a [KO:K02677] [EC:2.7.11.13]
134877835  prkcab; protein kinase C alpha type isoform X1 [KO:K02677] [EC:2.7.11.13]
134864323  protein kinase C beta type isoform X1 [KO:K19662] [EC:2.7.11.13]
134877800  LOW QUALITY PROTEIN: protein kinase C beta type-like [KO:K19662] [EC:2.7.11.13]
134861768  prkcg; protein kinase C gamma type [KO:K19663] [EC:2.7.11.13]
134862465  focal adhesion kinase 1-like isoform X1 [KO:K05725] [EC:2.7.10.2]
134874721  ptk2aa; protein tyrosine kinase 2aa isoform X1 [KO:K05725] [EC:2.7.10.2]
134863333  pik3cd; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform isoform X1 [KO:K00922] [EC:2.7.1.153]
134869576  phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform-like [KO:K00922] [EC:2.7.1.153]
134866128  phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform [KO:K00922] [EC:2.7.1.153]
134880313  pik3cb; LOW QUALITY PROTEIN: phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform [KO:K00922] [EC:2.7.1.153]
134869270  pik3r3b; phosphoinositide-3-kinase, regulatory subunit 3b (gamma) isoform X1 [KO:K02649]
134865729  phosphatidylinositol 3-kinase regulatory subunit gamma-like [KO:K02649]
134865816  pik3r2; phosphatidylinositol 3-kinase regulatory subunit beta isoform X1 [KO:K02649]
134869506  phosphatidylinositol 3-kinase regulatory subunit gamma-like isoform X1 [KO:K02649]
134868191  pik3r1; phosphatidylinositol 3-kinase regulatory subunit alpha [KO:K02649]
134873278  phosphatidylinositol 3-kinase regulatory subunit alpha-like [KO:K02649]
134858761  phosphatidylinositol 3,4,5-trisphosphate 3-phosphatase and dual-specificity protein phosphatase PTEN isoform X1 [KO:K01110] [EC:3.1.3.16 3.1.3.48 3.1.3.67]
134870375  ptenb; LOW QUALITY PROTEIN: phosphatidylinositol 3,4,5-trisphosphate 3-phosphatase and dual-specificity protein phosphatase PTEN [KO:K01110] [EC:3.1.3.16 3.1.3.48 3.1.3.67]
134864383  LOW QUALITY PROTEIN: proto-oncogene vav-like [KO:K05730]
134866606  guanine nucleotide exchange factor VAV3-like isoform X1 [KO:K05730]
134868277  vav2; guanine nucleotide exchange factor VAV2 isoform X1 [KO:K05730]
134883915  guanine nucleotide exchange factor VAV3 [KO:K05730]
134870527  ras-related C3 botulinum toxin substrate 1 [KO:K04392]
134878163  ras-related C3 botulinum toxin substrate 1-like [KO:K04392]
134862788  rac2; ras-related C3 botulinum toxin substrate 2 [KO:K07860]
134870859  rac3b; ras-related C3 botulinum toxin substrate 3b [KO:K07861]
134880087  pak1; LOW QUALITY PROTEIN: serine/threonine-protein kinase PAK 1 [KO:K04409] [EC:2.7.11.1]
134869475  pak2b; serine/threonine-protein kinase PAK 2b [KO:K04410] [EC:2.7.11.1]
134881417  serine/threonine-protein kinase PAK 2-like [KO:K04410] [EC:2.7.11.1]
134872466  LOW QUALITY PROTEIN: serine/threonine-protein kinase PAK 3-like [KO:K05733] [EC:2.7.11.1]
134880219  pak4; serine/threonine-protein kinase PAK 4 [KO:K05734] [EC:2.7.11.1]
134876468  pak5; serine/threonine-protein kinase PAK 5 isoform X1 [KO:K05736] [EC:2.7.11.1]
134881003  serine/threonine-protein kinase PAK 4 [KO:K05735] [EC:2.7.11.1]
134864636  cell division control protein 42 homolog isoform X1 [KO:K04393]
134861301  cdc42l; cell division cycle 42, like [KO:K04393]
134874641  cell division control protein 42 homolog [KO:K04393]
134882685  LOW QUALITY PROTEIN: cell division control protein 42 homolog [KO:K04393]
134882406  bcar1; LOW QUALITY PROTEIN: breast cancer anti-estrogen resistance protein 1 [KO:K05726]
134868485  crkl; crk-like protein [KO:K04438]
134872004  adapter molecule crk-like [KO:K04438]
134879932  LOW QUALITY PROTEIN: adapter molecule crk-like [KO:K04438]
134870774  dock1; dedicator of cytokinesis protein 1 [KO:K13708]
134868251  rapgef1b; rap guanine nucleotide exchange factor 1b isoform X1 [KO:K06277]
134873710  rapgef1a; rap guanine nucleotide exchange factor 1 [KO:K06277]
134862380  ras-related protein Rap-1A [KO:K04353]
134883005  ras-related protein Rap-1A-like [KO:K04353]
134879365  ras-related protein Rap-1b [KO:K07836]
134868533  mapk10; mitogen-activated protein kinase 10 isoform X1 [KO:K04440] [EC:2.7.11.24]
134859047  mapk8a; mitogen-activated protein kinase 8 isoform X1 [KO:K04440] [EC:2.7.11.24]
134859865  mapk9; mitogen-activated protein kinase 9 isoform X1 [KO:K04440] [EC:2.7.11.24]
134870548  mapk8b; mitogen-activated protein kinase 8 isoform X1 [KO:K04440] [EC:2.7.11.24]
134868643  june; junE proto-oncogene, AP-1 transcription factor subunit [KO:K04448]
134866042  transcription factor Jun-like [KO:K04448]
134869936  jun; transcription factor AP-1 [KO:K04448]
134879164  braf; serine/threonine-protein kinase B-raf isoform X1 [KO:K04365] [EC:2.7.11.1]
134884162  cav1; caveolin-1 [KO:K06278]
134871597  cav4b; caveolin-2 [KO:K12958]
134883544  caveolin-2-like [KO:K12958]
134882986  cav2; caveolin-2 [KO:K12958]
134883338  cav4a; caveolin-2 [KO:K12958]
134883152  cav3; caveolin-3 [KO:K12959]
134881806  fyna; tyrosine-protein kinase fyna [KO:K05703] [EC:2.7.10.2]
134877131  fynb; tyrosine-protein kinase fynb isoform X1 [KO:K05703] [EC:2.7.10.2]
134861829  shc1; SHC-transforming protein 1 isoform X1 [KO:K06279]
134869118  shc2; SHC-transforming protein 2 isoform X1 [KO:K17447]
134867979  shc3; SHC-transforming protein 3 [KO:K17448]
134863773  SHC-transforming protein 1-like isoform X1 [KO:K17449]
134878303  grb2b; growth factor receptor-bound protein 2b [KO:K04364]
134862968  LOW QUALITY PROTEIN: son of sevenless homolog 1-like [KO:K03099]
134881897  sos2; son of sevenless homolog 2 isoform X1 [KO:K03099]
134876142  hrasb; HRas proto-oncogene, GTPase b isoform X1 [KO:K02833]
134865609  raf1a; raf-1 proto-oncogene, serine/threonine kinase a isoform X1 [KO:K04366] [EC:2.7.11.1]
134879440  map2k1; dual specificity mitogen-activated protein kinase kinase 1 [KO:K04368] [EC:2.7.12.2]
134877926  mapk3; mitogen-activated protein kinase 3 [KO:K04371] [EC:2.7.11.24]
134873272  mapk1; mitogen-activated protein kinase 1 [KO:K04371] [EC:2.7.11.24]
134866294  elk1; ETS domain-containing protein Elk-1 [KO:K04375]
134863518  ccnd1; G1/S-specific cyclin-D1 [KO:K04503]
134882412  G1/S-specific cyclin-D1-like isoform X1 [KO:K04503]
134877636  ccnd2a; G1/S-specific cyclin-D2a [KO:K10151]
134879343  G1/S-specific cyclin-D2-like [KO:K10151]
134877473  ccndx; cyclin Dx [KO:K10151]
134883501  ccnd3; G1/S-specific cyclin-D3 [KO:K10152]
134871736  birc2; baculoviral IAP repeat-containing protein 2 isoform X1 [KO:K16060]
134859884  xiap; E3 ubiquitin-protein ligase XIAP [KO:K04725] [EC:2.3.2.27]
134875663  badb; BCL2 associated agonist of cell death b isoform X1 [KO:K02158]
134865945  bcl2b; apoptosis regulator Bcl-2 isoform X1 [KO:K02161]
Compound
C04637  1-Phosphatidyl-D-myo-inositol 4,5-bisphosphate
C05981  Phosphatidylinositol-3,4,5-trisphosphate
Reference
PMID:14756624
  Authors
Berman AE, Kozlova NI, Morozevich GE.
  Title
Integrins: structure and signaling.
  Journal
Biochemistry (Mosc) 68:1284-99 (2003)
DOI:10.1023/b:biry.0000011649.03634.74
Reference
PMID:15179030
  Authors
Lee JW, Juliano R.
  Title
Mitogenic signal transduction by integrin- and growth factor receptor-mediated pathways.
  Journal
Mol Cells 17:188-202 (2004)
Reference
PMID:11573199
  Authors
Danen EH, Yamada KM.
  Title
Fibronectin, integrins, and growth control.
  Journal
J Cell Physiol 189:1-13 (2001)
DOI:10.1002/jcp.1137
Reference
PMID:15459662
  Authors
Guo W, Giancotti FG.
  Title
Integrin signalling during tumour progression.
  Journal
Nat Rev Mol Cell Biol 5:816-26 (2004)
DOI:10.1038/nrm1490
Reference
PMID:11229600
  Authors
Petit V, Thiery JP.
  Title
Focal adhesions: structure and dynamics.
  Journal
Biol Cell 92:477-94 (2000)
DOI:10.1016/S0248-4900(00)01101-1
Reference
PMID:12235283
  Authors
Stupack DG, Cheresh DA.
  Title
Get a ligand, get a life: integrins, signaling and cell survival.
  Journal
J Cell Sci 115:3729-38 (2002)
DOI:10.1242/jcs.00071
Reference
PMID:12640026
  Authors
Parsons JT.
  Title
Focal adhesion kinase: the first ten years.
  Journal
J Cell Sci 116:1409-16 (2003)
DOI:10.1242/jcs.00373
Reference
PMID:15688067
  Authors
Mitra SK, Hanson DA, Schlaepfer DD.
  Title
Focal adhesion kinase: in command and control of cell motility.
  Journal
Nat Rev Mol Cell Biol 6:56-68 (2005)
DOI:10.1038/nrm1549
Reference
PMID:14519391
  Authors
Comoglio PM, Boccaccio C, Trusolino L.
  Title
Interactions between growth factor receptors and adhesion molecules: breaking the rules.
  Journal
Curr Opin Cell Biol 15:565-71 (2003)
DOI:10.1016/S0955-0674(03)00096-6
Reference
PMID:15108811
  Authors
Schlaepfer DD, Mitra SK.
  Title
Multiple connections link FAK to cell motility and invasion.
  Journal
Curr Opin Genet Dev 14:92-101 (2004)
DOI:10.1016/j.gde.2003.12.002
Reference
PMID:14744429
  Authors
Burridge K, Wennerberg K.
  Title
Rho and Rac take center stage.
  Journal
Cell 116:167-79 (2004)
DOI:10.1016/S0092-8674(04)00003-0
Reference
PMID:11082269
  Authors
Schmitz AA, Govek EE, Bottner B, Van Aelst L.
  Title
Rho GTPases: signaling, migration, and invasion.
  Journal
Exp Cell Res 261:1-12 (2000)
DOI:10.1006/excr.2000.5049
Reference
PMID:10698680
  Authors
Vanhaesebroeck B, Alessi DR.
  Title
The PI3K-PDK1 connection: more than just a road to PKB.
  Journal
Biochem J 346 Pt 3:561-76 (2000)
DOI:10.1042/bj3460561
Reference
PMID:11882383
  Authors
Nicholson KM, Anderson NG.
  Title
The protein kinase B/Akt signalling pathway in human malignancy.
  Journal
Cell Signal 14:381-95 (2002)
DOI:10.1016/S0898-6568(01)00271-6
Reference
PMID:15053919
  Authors
Oloumi A, McPhee T, Dedhar S.
  Title
Regulation of E-cadherin expression and beta-catenin/Tcf transcriptional activity by the integrin-linked kinase.
  Journal
Biochim Biophys Acta 1691:1-15 (2004)
DOI:10.1016/j.bbamcr.2003.12.002
Reference
PMID:11146675
  Authors
Turner CE.
  Title
Paxillin and focal adhesion signalling.
  Journal
Nat Cell Biol 2:E231-6 (2000)
DOI:10.1038/35046659
Reference
PMID:15034601
  Authors
Hlobilkova A, Knillova J, Bartek J, Lukas J, Kolar Z.
  Title
The mechanism of action of the tumour suppressor gene PTEN.
  Journal
Biomed Pap Med Fac Univ Palacky Olomouc Czech Repub 147:19-25 (2003)
Related
pathway
emac04010  MAPK signaling pathway
emac04060  Cytokine-cytokine receptor interaction
emac04070  Phosphatidylinositol signaling system
emac04110  Cell cycle
emac04310  Wnt signaling pathway
emac04512  ECM-receptor interaction
emac04810  Regulation of actin cytoskeleton
KO pathway
ko04510   
LinkDB

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