KEGG   PATHWAY: etf05152
Entry
etf05152                    Pathway                                
Name
Tuberculosis - Echinops telfairi (small Madagascar hedgehog)
Description
Tuberculosis, or TB, is an infectious disease caused by Mycobacterium tuberculosis. One third of the world's population is thought to be infected with TB. About 90% of those infected result in latent infections, and about 10% of latent infections develop active diseases when their immune system is impaired due to the age, other diseases such as AIDS or exposure to immunosuppressive drugs. TB is transmitted through the air and primarily attacks the lungs, then it can spread by the circulatory system to other parts of body. Once TB bacilli have entered the host by the respiratory route and infected macrophages in the lungs, they interfere with phagosomal maturation, antigen presentation, apoptosis and host immune system to establish persistent or latent infection.
Class
Human Diseases; Infectious disease: bacterial
Pathway map
etf05152  Tuberculosis
etf05152

Organism
Echinops telfairi (small Madagascar hedgehog) [GN:etf]
Gene
101654642  TNF; tumor necrosis factor [KO:K03156]
101657422  TNFRSF1A; tumor necrosis factor receptor superfamily member 1A [KO:K03158]
101643813  TRADD; tumor necrosis factor receptor type 1-associated DEATH domain protein isoform X3 [KO:K03171]
101638051  CASP8; caspase-8 [KO:K04398] [EC:3.4.22.61]
101664540  CASP10; caspase-10 [KO:K04400] [EC:3.4.22.63]
101643856  CASP3; caspase-3 isoform X1 [KO:K02187] [EC:3.4.22.56]
101659226  BID; BH3-interacting domain death agonist [KO:K04726]
101646711  BAX; apoptosis regulator BAX [KO:K02159]
101661288  cytochrome c, testis-specific [KO:K08738]
101650600  cytochrome c-like [KO:K08738]
101659735  CASP9; caspase-9 [KO:K04399] [EC:3.4.22.62]
101656765  APAF1; apoptotic protease-activating factor 1 [KO:K02084]
101643102  AKT2; RAC-beta serine/threonine-protein kinase [KO:K04456] [EC:2.7.11.1]
101649881  AKT1; RAC-alpha serine/threonine-protein kinase [KO:K04456] [EC:2.7.11.1]
101655315  AKT3; RAC-gamma serine/threonine-protein kinase isoform X1 [KO:K04456] [EC:2.7.11.1]
101658729  BAD; bcl2-associated agonist of cell death [KO:K02158]
101659722  BCL2; apoptosis regulator Bcl-2 [KO:K02161]
101644337  CAMK2G; calcium/calmodulin-dependent protein kinase type II subunit gamma [KO:K04515] [EC:2.7.11.17]
101651457  CAMK2D; calcium/calmodulin-dependent protein kinase type II subunit delta isoform X3 [KO:K04515] [EC:2.7.11.17]
101664486  CAMK2A; calcium/calmodulin-dependent protein kinase type II subunit alpha isoform X1 [KO:K04515] [EC:2.7.11.17]
101638605  CAMK2B; calcium/calmodulin-dependent protein kinase type II subunit beta isoform X1 [KO:K04515] [EC:2.7.11.17]
101644328  IFNG; interferon gamma [KO:K04687]
101642657  IFNGR1; interferon gamma receptor 1 [KO:K05132]
101640830  IFNGR2; interferon gamma receptor 2 [KO:K05133]
101664197  JAK1; tyrosine-protein kinase JAK1 isoform X1 [KO:K11217] [EC:2.7.10.2]
101659376  JAK2; tyrosine-protein kinase JAK2 isoform X1 [KO:K04447] [EC:2.7.10.2]
101650838  STAT1; signal transducer and activator of transcription 1-alpha/beta [KO:K11220]
101645950  CIITA; MHC class II transactivator [KO:K08060] [EC:2.7.11.1]
101664521  RFX5; DNA-binding protein RFX5 [KO:K08061]
101658344  RFXANK; DNA-binding protein RFXANK isoform X1 [KO:K08062]
101664682  regulatory factor X-associated protein [KO:K08063]
101664050  NFYA; nuclear transcription factor Y subunit alpha isoform X2 [KO:K08064]
101641911  NFYB; nuclear transcription factor Y subunit beta [KO:K08065]
101664235  NFYC; nuclear transcription factor Y subunit gamma isoform X1 [KO:K08066]
101646557  CREB1; cyclic AMP-responsive element-binding protein 1 isoform X1 [KO:K05870]
101651698  HLA class II histocompatibility antigen, DM beta chain [KO:K06752]
101655577  HLA class II histocompatibility antigen, DR beta 5 chain-like [KO:K06752]
101655267  mamu class II histocompatibility antigen, DR alpha chain-like [KO:K06752]
123522014  HLA class II histocompatibility antigen, DO beta chain-like [KO:K06752]
101638712  mamu class II histocompatibility antigen, DR alpha chain-like [KO:K06752]
101639035  mamu class II histocompatibility antigen, DR alpha chain-like [KO:K06752]
101652007  HLA class II histocompatibility antigen, DM alpha chain isoform X1 [KO:K06752]
101652643  HLA class II histocompatibility antigen, DO alpha chain [KO:K06752]
101651302  CD74; HLA class II histocompatibility antigen gamma chain [KO:K06505]
101641939  CREB-binding protein [KO:K04498] [EC:2.3.1.48]
101647070  EP300; histone acetyltransferase p300 isoform X2 [KO:K04498] [EC:2.3.1.48]
101650414  IL10; interleukin-10 [KO:K05443]
101658397  IL10RA; interleukin-10 receptor subunit alpha [KO:K05134]
101639885  IL10RB; interleukin-10 receptor subunit beta isoform X1 [KO:K05135]
101656344  CTSS; cathepsin S [KO:K01368] [EC:3.4.22.27]
101638172  CLEC4E; C-type lectin domain family 4 member E [KO:K10059]
101658860  FCER1G; high affinity immunoglobulin epsilon receptor subunit gamma [KO:K07983]
101645068  CLEC7A; C-type lectin domain family 7 member A isoform X3 [KO:K10074]
101640115  SRC; proto-oncogene tyrosine-protein kinase Src isoform X1 [KO:K05704] [EC:2.7.10.2]
101654763  SYK; tyrosine-protein kinase SYK [KO:K05855] [EC:2.7.10.2]
101651114  CARD9; caspase recruitment domain-containing protein 9 isoform X1 [KO:K12794]
101655747  MALT1; mucosa-associated lymphoid tissue lymphoma translocation protein 1 [KO:K07369] [EC:3.4.22.-]
101646857  BCL10; B-cell lymphoma/leukemia 10 [KO:K07368]
101661310  NOD2; nucleotide-binding oligomerization domain-containing protein 2 [KO:K10165]
101659564  RIPK2; receptor-interacting serine/threonine-protein kinase 2 [KO:K08846] [EC:2.7.11.1]
101640216  HSPA9; stress-70 protein, mitochondrial [KO:K04043]
101657295  HSPD1; 60 kDa heat shock protein, mitochondrial [KO:K04077] [EC:5.6.1.7]
101658382  LOW QUALITY PROTEIN: 60 kDa heat shock protein, mitochondrial-like [KO:K04077] [EC:5.6.1.7]
123522309  lipopolysaccharide-binding protein-like [KO:K05399]
101647583  lipopolysaccharide-binding protein [KO:K05399]
101643417  TLR2; toll-like receptor 2 isoform X1 [KO:K10159]
101664435  TLR1; toll-like receptor 1 [KO:K05398]
101664124  TLR6; toll-like receptor 6 [KO:K10169]
101660600  TLR4; toll-like receptor 4 [KO:K10160]
101652025  monocyte differentiation antigen CD14-like [KO:K04391]
101652337  monocyte differentiation antigen CD14-like [KO:K04391]
101642196  toll/interleukin-1 receptor domain-containing adapter protein isoform X1 [KO:K05403]
101644448  MYD88; myeloid differentiation primary response protein MyD88 [KO:K04729]
101643108  IRAK4; interleukin-1 receptor-associated kinase 4 isoform X2 [KO:K04733] [EC:2.7.11.1]
101652271  IRAK1; interleukin-1 receptor-associated kinase 1 [KO:K04730] [EC:2.7.11.1]
101639521  IRAK2; interleukin-1 receptor-associated kinase-like 2 isoform X1 [KO:K04731] [EC:2.7.11.1]
101658809  TRAF6; TNF receptor-associated factor 6 [KO:K03175] [EC:2.3.2.27]
101662652  NFKB1; nuclear factor NF-kappa-B p105 subunit isoform X1 [KO:K02580]
101663870  RELA; transcription factor p65 [KO:K04735]
101657745  MAPK13; mitogen-activated protein kinase 13 [KO:K04441] [EC:2.7.11.24]
101656204  MAPK14; mitogen-activated protein kinase 14 isoform X1 [KO:K04441] [EC:2.7.11.24]
101653430  MAPK11; mitogen-activated protein kinase 11 [KO:K04441] [EC:2.7.11.24]
101653940  MAPK12; mitogen-activated protein kinase 12 isoform X1 [KO:K04441] [EC:2.7.11.24]
101648971  MAPK3; mitogen-activated protein kinase 3 [KO:K04371] [EC:2.7.11.24]
101661786  MAPK1; mitogen-activated protein kinase 1 [KO:K04371] [EC:2.7.11.24]
101654493  MAPK10; mitogen-activated protein kinase 10 isoform X1 [KO:K04440] [EC:2.7.11.24]
101653598  MAPK9; mitogen-activated protein kinase 9 isoform X1 [KO:K04440] [EC:2.7.11.24]
101645489  MAPK8; mitogen-activated protein kinase 8 isoform X1 [KO:K04440] [EC:2.7.11.24]
101657111  NOS2; nitric oxide synthase, inducible [KO:K13241] [EC:1.14.13.39]
123522712  interleukin-6-like [KO:K05405]
101644240  IL6; interleukin-6 [KO:K05405]
101641618  IL12A; interleukin-12 subunit alpha [KO:K05406]
101650484  IL12B; interleukin-12 subunit beta [KO:K05425]
105978242  IL18; interleukin-18 [KO:K05482]
101661380  IL23A; interleukin-23 subunit alpha [KO:K05426]
101638698  IL1A; interleukin-1 alpha [KO:K04383]
101639333  IL1B; interleukin-1 beta [KO:K04519]
101655660  CEBPG; CCAAT/enhancer-binding protein gamma [KO:K10049]
115872044  TLR9; toll-like receptor 9 [KO:K10161]
101650862  interferon alpha-2-like [KO:K05414]
101650550  IFNB1; interferon beta [KO:K05415]
101662740  CD209 antigen-like protein C isoform X3 [KO:K06563]
101646828  ARHGEF12; rho guanine nucleotide exchange factor 12 isoform X1 [KO:K07532]
101662299  RHOA; transforming protein RhoA [KO:K04513]
101646755  PLK3; serine/threonine-protein kinase PLK3 [KO:K08862] [EC:2.7.11.21]
101657723  KSR1; kinase suppressor of Ras 1 isoform X6 [KO:K14958]
101656360  RAF1; RAF proto-oncogene serine/threonine-protein kinase isoform X3 [KO:K04366] [EC:2.7.11.1]
101650988  TGFB1; transforming growth factor beta-1 proprotein [KO:K13375]
101639819  TGFB2; transforming growth factor beta-2 proprotein isoform X2 [KO:K13376]
101642513  TGFB3; transforming growth factor beta-3 proprotein [KO:K13377]
101646226  25-hydroxyvitamin D-1 alpha hydroxylase, mitochondrial [KO:K07438] [EC:1.14.15.18]
101663644  VDR; vitamin D3 receptor [KO:K08539]
101641205  cathelicidin antimicrobial peptide [KO:K13916]
101661246  C3; complement C3 [KO:K03990]
101654788  complement receptor type 1-like [KO:K04011]
101657313  integrin alpha-X [KO:K06462]
101642606  ITGB2; integrin beta-2 [KO:K06464]
101657619  ITGAM; integrin alpha-M [KO:K06461]
101652189  PLA2R1; secretory phospholipase A2 receptor [KO:K06560]
101655556  MRC2; C-type mannose receptor 2 [KO:K06560]
101650617  MRC1; macrophage mannose receptor 1 [KO:K06560]
101653999  SPHK1; sphingosine kinase 1 [KO:K04718] [EC:2.7.1.91]
101647651  SPHK2; sphingosine kinase 2 isoform X2 [KO:K04718] [EC:2.7.1.91]
115871000  calmodulin-A-like [KO:K02183]
101651650  neo-calmodulin-like [KO:K02183]
101662569  CALML6; calmodulin-like protein 6 [KO:K02183]
101656820  CALM3; calmodulin-3 [KO:K02183]
101638094  calmodulin-alpha-like [KO:K02183]
101650375  CALML3; calmodulin-like protein 3 [KO:K02183]
101662916  CALML5; calmodulin-like protein 5 [KO:K02183]
101654870  CALM1; calmodulin-1 [KO:K02183]
101649322  CALML4; calmodulin-like protein 4 isoform X1 [KO:K02183]
101643468  CALM2; calmodulin-2 [KO:K02183]
101644561  PIK3C3; phosphatidylinositol 3-kinase catalytic subunit type 3 [KO:K00914] [EC:2.7.1.137]
101652923  ras-related protein Rab-5A-like [KO:K07887]
101652509  RAB5A; ras-related protein Rab-5A [KO:K07887]
101643370  RAB5B; ras-related protein Rab-5B [KO:K07888]
101655554  RAB5C; ras-related protein Rab-5C [KO:K07889]
101664307  EEA1; early endosome antigen 1 [KO:K12478]
101648456  RAB7A; ras-related protein Rab-7a [KO:K07897]
101654577  CTSD; cathepsin D [KO:K01379] [EC:3.4.23.5]
101642891  ATP6V0A2; V-type proton ATPase 116 kDa subunit a2 [KO:K02154]
101661946  ATP6V0A1; V-type proton ATPase 116 kDa subunit a1 [KO:K02154]
101655807  TCIRG1; V-type proton ATPase 116 kDa subunit a3 [KO:K02154]
101663969  ATP6V0A4; V-type proton ATPase 116 kDa subunit a [KO:K02154]
101660301  ATP6V0D2; V-type proton ATPase subunit d 2 [KO:K02146]
101638374  ATP6V0D1; V-type proton ATPase subunit d 1 [KO:K02146]
101660096  ATP6V1H; V-type proton ATPase subunit H isoform X1 [KO:K02144]
101649798  ATP6AP1; V-type proton ATPase subunit S1 [KO:K03662]
101652929  V-type proton ATPase 16 kDa proteolipid subunit-like [KO:K02155]
101637885  V-type proton ATPase 16 kDa proteolipid subunit [KO:K02155]
101639603  ATP6V0B; V-type proton ATPase 21 kDa proteolipid subunit [KO:K03661]
101644892  LAMP1; lysosome-associated membrane glycoprotein 1 [KO:K06528]
101658925  LAMP2; lysosome-associated membrane glycoprotein 2 isoform X2 [KO:K06528]
101639952  PPP3CA; serine/threonine-protein phosphatase 2B catalytic subunit alpha isoform [KO:K04348] [EC:3.1.3.16]
101642124  PPP3CB; serine/threonine-protein phosphatase 2B catalytic subunit beta isoform isoform X4 [KO:K04348] [EC:3.1.3.16]
101638696  PPP3CC; serine/threonine-protein phosphatase 2B catalytic subunit gamma isoform isoform X1 [KO:K04348] [EC:3.1.3.16]
101660901  PPP3R1; calcineurin subunit B type 1 [KO:K06268]
101647023  PPP3R2; calcineurin subunit B type 2 [KO:K06268]
101649290  CORO1A; coronin-1A [KO:K13882]
101660247  FCGR2B; low affinity immunoglobulin gamma Fc region receptor II-b isoform X1 [KO:K12560]
101660563  low affinity immunoglobulin gamma Fc region receptor III-B-like [KO:K06463]
Compound
C00076  Calcium cation
C00338  Lipopolysaccharide
C01194  1-Phosphatidyl-D-myo-inositol
C01561  Calcidiol
C01673  Calcitriol
C04549  1-Phosphatidyl-1D-myo-inositol 3-phosphate
C06124  Sphingosine 1-phosphate
C19190  Trehalose-6,6'-dibehenate
C21790  Mycobacterial trehalose dimycolate
G13101  Lipomannan
G13105  Triacylated phosphatidyl-myo-inositol pentamannoside
G13106  Triacylated phosphatidyl-myo-inositol hexamannoside
G13108  Triacylated phosphatidyl-myo-inositol dimannoside
G13109  Tetraacylated phosphatidyl-myo-inositol dimannoside
G13112  Tetraacylated phosphatidyl-myo-inositol hexamannoside
G13113  Tetraacylated phosphatidyl-myo-inositol pentamannoside
G13114  Lipoarabinomannan
G13115  Mannose-capped lipoarabinomannan
Reference
PMID:21274449
  Authors
Saiga H, Shimada Y, Takeda K
  Title
Innate immune effectors in mycobacterial infection.
  Journal
Clin Dev Immunol 2011:347594 (2011)
DOI:10.1155/2011/347594
Reference
PMID:20415982
  Authors
Dheda K, Schwander SK, Zhu B, van Zyl-Smit RN, Zhang Y
  Title
The immunology of tuberculosis: from bench to bedside.
  Journal
Respirology 15:433-50 (2010)
DOI:10.1111/j.1440-1843.2010.01739.x
Reference
PMID:11932234
  Authors
van Crevel R, Ottenhoff TH, van der Meer JW
  Title
Innate immunity to Mycobacterium tuberculosis.
  Journal
Clin Microbiol Rev 15:294-309 (2002)
DOI:10.1128/CMR.15.2.294-309.2002
Reference
PMID:18288961
  Authors
Torrelles JB, Azad AK, Henning LN, Carlson TK, Schlesinger LS
  Title
Role of C-type lectins in mycobacterial infections.
  Journal
Curr Drug Targets 9:102-12 (2008)
DOI:10.2174/138945008783502467
Reference
PMID:17359235
  Authors
Jo EK, Yang CS, Choi CH, Harding CV
  Title
Intracellular signalling cascades regulating innate immune responses to Mycobacteria: branching out from Toll-like receptors.
  Journal
Cell Microbiol 9:1087-98 (2007)
DOI:10.1111/j.1462-5822.2007.00914.x
Reference
PMID:21274433
  Authors
Marakalala MJ, Graham LM, Brown GD
  Title
The role of Syk/CARD9-coupled C-type lectin receptors in immunity to Mycobacterium tuberculosis infections.
  Journal
Clin Dev Immunol 2010:567571 (2010)
DOI:10.1155/2010/567571
Reference
PMID:15083155
  Authors
Koul A, Herget T, Klebl B, Ullrich A
  Title
Interplay between mycobacteria and host signalling pathways.
  Journal
Nat Rev Microbiol 2:189-202 (2004)
DOI:10.1038/nrmicro840
Reference
PMID:20199890
  Authors
Torrelles JB, Schlesinger LS
  Title
Diversity in Mycobacterium tuberculosis mannosylated cell wall determinants impacts adaptation to the host.
  Journal
Tuberculosis (Edinb) 90:84-93 (2010)
DOI:10.1016/j.tube.2010.02.003
Reference
PMID:15228522
  Authors
Briken V, Porcelli SA, Besra GS, Kremer L
  Title
Mycobacterial lipoarabinomannan and related lipoglycans: from biogenesis to modulation of the immune response.
  Journal
Mol Microbiol 53:391-403 (2004)
DOI:10.1111/j.1365-2958.2004.04183.x
Reference
PMID:19563525
  Authors
Baena A, Porcelli SA
  Title
Evasion and subversion of antigen presentation by Mycobacterium tuberculosis.
  Journal
Tissue Antigens 74:189-204 (2009)
DOI:10.1111/j.1399-0039.2009.01301.x
Reference
PMID:19369951
  Authors
Flannagan RS, Cosio G, Grinstein S
  Title
Antimicrobial mechanisms of phagocytes and bacterial evasion strategies.
  Journal
Nat Rev Microbiol 7:355-66 (2009)
DOI:10.1038/nrmicro2128
Reference
PMID:18541216
  Authors
Pieters J
  Title
Mycobacterium tuberculosis and the macrophage: maintaining a balance.
  Journal
Cell Host Microbe 3:399-407 (2008)
DOI:10.1016/j.chom.2008.05.006
Reference
PMID:19634703
  Authors
Scherr N, Jayachandran R, Mueller P, Pieters J
  Title
Interference of Mycobacterium tuberculosis with macrophage responses.
  Journal
Indian J Exp Biol 47:401-6 (2009)
Reference
PMID:16200082
  Authors
Reith W, LeibundGut-Landmann S, Waldburger JM.
  Title
Regulation of MHC class II gene expression by the class II transactivator.
  Journal
Nat Rev Immunol 5:793-806 (2005)
DOI:10.1038/nri1708
Reference
PMID:17785780
  Authors
Rothfuchs AG, Bafica A, Feng CG, Egen JG, Williams DL, Brown GD, Sher A
  Title
Dectin-1 interaction with Mycobacterium tuberculosis leads to enhanced IL-12p40 production by splenic dendritic cells.
  Journal
J Immunol 179:3463-71 (2007)
DOI:10.4049/jimmunol.179.6.3463
Reference
PMID:18407066
  Authors
Master SS, Rampini SK, Davis AS, Keller C, Ehlers S, Springer B, Timmins GS, Sander P, Deretic V
  Title
Mycobacterium tuberculosis prevents inflammasome activation.
  Journal
Cell Host Microbe 3:224-32 (2008)
DOI:10.1016/j.chom.2008.03.003
Reference
PMID:11378475
  Authors
Shtrichman R, Samuel CE
  Title
The role of gamma interferon in antimicrobial immunity.
  Journal
Curr Opin Microbiol 4:251-9 (2001)
DOI:10.1016/S1369-5274(00)00199-5
Related
pathway
etf04010  MAPK signaling pathway
etf04210  Apoptosis
etf04612  Antigen processing and presentation
etf04620  Toll-like receptor signaling pathway
etf04621  NOD-like receptor signaling pathway
etf04630  JAK-STAT signaling pathway
KO pathway
ko05152   
LinkDB

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