KEGG   PATHWAY: gacu05132
Entry
gacu05132                   Pathway                                
Name
Salmonella infection - Gymnodraco acuticeps
Description
Salmonella infection usually presents as a self-limiting gastroenteritis or the more severe typhoid fever and bacteremia. The common disease-causing Salmonella species in human is a single species, Salmonella enterica, which has numerous serovars.
Following intestinal colonization Salmonella inject effector proteins into the host cells using a type III secretion system (T3SS), T3SS1. Then a small group of effector proteins induce rearrangement of the actin cytoskeleton resulting in membrane ruffles and rapid internalization of the bacteria.The T3SS2 is responsible for translocating effector proteins that direct Salmonella-containing vacuole (SCV) maturation. The majority of the bacteria are known to survive and replicate in SCV.
Class
Human Diseases; Infectious disease: bacterial
Pathway map
gacu05132  Salmonella infection
gacu05132

Organism
Gymnodraco acuticeps [GN:gacu]
Gene
117558782  podxl; podocalyxin [KO:K06817]
117540546  ptprc; receptor-type tyrosine-protein phosphatase C isoform X1 [KO:K06478] [EC:3.1.3.48]
117543275  rab5ab; RAB5A, member RAS oncogene family, b [KO:K07887]
117562985  ras-related protein Rab-5A-like [KO:K07887]
117553473  ras-related protein Rab-5B-like [KO:K07888]
117561491  ras-related protein Rab-5B-like [KO:K07888]
117545136  ras-related protein Rab-5C-like [KO:K07889]
117548825  rab5c; ras-related protein Rab-5C [KO:K07889]
117539199  pik3c3; phosphatidylinositol 3-kinase catalytic subunit type 3 isoform X1 [KO:K00914] [EC:2.7.1.137]
117543726  si:dkey-13a21.4; ras-related protein Rab-7a [KO:K07897]
117543733  rab7a; ras-related protein Rab-7a [KO:K07897]
117551124  ras-related protein rab7-like [KO:K07897]
117547409  plekhm1; pleckstrin homology domain-containing family M member 1 [KO:K23282]
117557222  vps11; vacuolar protein sorting-associated protein 11 homolog [KO:K20179]
117557417  vps16; vacuolar protein sorting-associated protein 16 homolog [KO:K20180]
117554375  vps18; vacuolar protein sorting-associated protein 18 homolog [KO:K20181]
117543838  vps33a; vacuolar protein sorting-associated protein 33A [KO:K20182]
117551931  vps39; vam6/Vps39-like protein [KO:K20183]
117544781  vps41; vacuolar protein sorting-associated protein 41 homolog [KO:K20184]
117552121  rilp; RILP-like protein 1 [KO:K13883]
117556390  dync1h1; cytoplasmic dynein 1 heavy chain 1 [KO:K10413]
117552140  cytoplasmic dynein 2 heavy chain 1 isoform X1 [KO:K10414]
117532625  cytoplasmic dynein 1 intermediate chain 2-like isoform X1 [KO:K10415]
117544373  cytoplasmic dynein 1 intermediate chain 2-like isoform X1 [KO:K10415]
117562892  LOW QUALITY PROTEIN: cytoplasmic dynein 1 intermediate chain 1 [KO:K10415]
117546478  dync1li2; cytoplasmic dynein 1 light intermediate chain 2 isoform X1 [KO:K10416]
117562931  dync1li1; cytoplasmic dynein 1 light intermediate chain 1 isoform X1 [KO:K10416]
117560801  dync2li1; LOW QUALITY PROTEIN: cytoplasmic dynein 2 light intermediate chain 1 [KO:K10417]
117540411  dynll2a; dynein, light chain, LC8-type 2a [KO:K10418]
117535138  dynll2b; dynein, light chain, LC8-type 2b [KO:K10418]
117560542  dynll1; dynein light chain 1, cytoplasmic [KO:K10418]
117545734  dynein light chain roadblock-type 2-like [KO:K10419]
117553333  dynlrb1; dynein light chain roadblock-type 1 [KO:K10419]
117556836  dynlt3; dynein light chain Tctex-type 3 [KO:K10420]
117556318  dynlt1; dynein light chain Tctex-type 1 [KO:K10420]
117547226  dynactin subunit 1-like isoform X1 [KO:K04648]
117558869  dctn1b; LOW QUALITY PROTEIN: dynactin subunit 1 [KO:K04648]
117534203  dctn2; dynactin subunit 2 isoform X1 [KO:K10424]
117559507  dctn3; dynactin subunit 3 [KO:K10425]
117556998  dctn4; dynactin subunit 4 isoform X1 [KO:K10426]
117535943  dctn5; dynactin subunit 5 [KO:K10427]
117537931  dynactin subunit 6-like [KO:K10428]
117562764  dynactin subunit 6-like [KO:K10428]
117554162  actr10; actin-related protein 10 [KO:K16576]
117537368  tubulin alpha chain-like [KO:K07374]
117537369  tubulin alpha-1B chain-like isoform X1 [KO:K07374]
117537370  tubulin alpha-1B chain [KO:K07374]
117537371  tubulin alpha-1B chain-like [KO:K07374]
117538345  tuba8l3; tubulin, alpha 8 like 3 [KO:K07374]
117538346  tubulin alpha chain-like [KO:K07374]
117538350  tubulin alpha chain-like [KO:K07374]
117546437  tubulin alpha-1B chain-like [KO:K07374]
117547683  tubulin alpha chain-like [KO:K07374]
117534575  tubulin alpha chain-like [KO:K07374]
117534588  tubulin alpha chain-like [KO:K07374]
117556578  tubulin alpha-1C chain-like [KO:K07374]
117561826  tubulin alpha-1A chain-like [KO:K07374]
117561828  LOW QUALITY PROTEIN: tubulin alpha-1D chain-like [KO:K07374]
117539688  tubulin beta chain-like isoform X1 [KO:K07375]
117539690  tubulin beta-1 chain-like [KO:K07375]
117539692  tubulin beta-1 chain-like [KO:K07375]
117539699  tubulin beta-1 chain-like [KO:K07375]
117534211  tubb1; tubulin beta-1 chain [KO:K07375]
117548427  tubb4bl; tubulin beta-4B chain [KO:K07375]
117534885  tubulin beta-1 chain isoform X1 [KO:K07375]
117549590  tubb5; LOW QUALITY PROTEIN: tubulin beta-5 chain [KO:K07375]
117558353  tubulin beta-2A chain isoform X1 [KO:K07375]
117558868  tubulin beta-1 chain [KO:K07375]
117561682  zgc:65894; tubulin beta-4B chain [KO:K07375]
117550937  fyco1a; FYVE and coiled-coil domain-containing protein 1 [KO:K21954]
117543766  arl8bb; ADP-ribosylation factor-like 8Bb [KO:K07955]
117548118  arl8ba; ADP-ribosylation factor-like protein 8B-A [KO:K07955]
117536301  ADP-ribosylation factor-like protein 8A [KO:K07955]
117532833  plekhm2; pleckstrin homology domain-containing family M member 2 isoform X1 [KO:K15348]
117545306  kinesin heavy chain-like [KO:K10396]
117539307  kinesin heavy chain-like [KO:K10396]
117552655  kinesin-1 heavy chain-like [KO:K10396]
117534214  kif5ab; kinesin heavy chain isoform X1 [KO:K10396]
117541892  kif5aa; kinesin family member 5Aa isoform X1 [KO:K10396]
117558484  kinesin-1 heavy chain-like isoform X1 [KO:K10396]
117555553  LOW QUALITY PROTEIN: kinesin light chain 2-like [KO:K10407]
117555614  klc3; kinesin light chain 3 [KO:K10407]
117558933  klc1a; kinesin light chain 1 isoform X1 [KO:K10407]
117562756  klc1b; LOW QUALITY PROTEIN: kinesin light chain 1b [KO:K10407]
117533797  acbd3; Golgi resident protein GCP60 isoform X1 [KO:K23935]
117551071  rho-related GTP-binding protein RhoA-B [KO:K04513]
117545976  rho-related GTP-binding protein RhoA-C-like [KO:K04513]
117547686  rho-related GTP-binding protein RhoA-C [KO:K04513]
117541780  rhoab; rho-related GTP-binding protein RhoA-B [KO:K04513]
117542099  rho-related GTP-binding protein RhoA-D [KO:K04513]
117543324  m6pr; cation-dependent mannose-6-phosphate receptor [KO:K10089]
117544388  rab9a; ras-related protein Rab-9A [KO:K07899]
117546587  ras-related protein Rab-9A-like [KO:K07899]
117557004  rab9b; ras-related protein Rab-9B [KO:K07900]
117560074  GRIP and coiled-coil domain-containing protein 2 [KO:K20282]
117534366  syntaxin-10-like [KO:K23937]
117545523  LOW QUALITY PROTEIN: profilin-2-like [KO:K05759]
117559718  profilin-2-like isoform X1 [KO:K05759]
117541488  flna; filamin-A isoform X1 [KO:K04437]
117553503  exoc7; exocyst complex component 7 isoform X1 [KO:K07195]
117549919  exoc5; exocyst complex component 5 [KO:K19984]
117547930  exoc4; LOW QUALITY PROTEIN: exocyst complex component 4 [KO:K06111]
117560547  exoc2; LOW QUALITY PROTEIN: exocyst complex component 2 [KO:K17637]
117544735  ralaa; v-ral simian leukemia viral oncogene homolog Aa (ras related) [KO:K07834]
117534596  actin, cytoplasmic 1-like [KO:K05692]
117534604  actin, cytoplasmic 1 [KO:K05692]
117534613  actin, cytoplasmic 1-like [KO:K05692]
117534622  actin, cytoplasmic 1-like [KO:K05692]
117556245  actb1; actin, cytoplasmic 1 [KO:K05692]
117542538  s100a10a; protein S100-A10a [KO:K17274]
117557689  annexin A2-like [KO:K17092]
117545378  zgc:101785; annexin A2 [KO:K17092]
117545286  si:ch211-125o16.4; neuroblast differentiation-associated protein AHNAK [KO:K23934]
117555815  ahnak; LOW QUALITY PROTEIN: neuroblast differentiation-associated protein AHNAK [KO:K23934]
117558938  neuroblast differentiation-associated protein AHNAK-like [KO:K23934]
117554813  rho guanine nucleotide exchange factor 26-like [KO:K13744]
117556949  rho-related GTP-binding protein RhoG-like [KO:K07863]
117560647  rho-related GTP-binding protein RhoG-like [KO:K07863]
117562920  elmo1; engulfment and cell motility protein 1 isoform X1 [KO:K12366]
117547494  elmo2; LOW QUALITY PROTEIN: engulfment and cell motility protein 2 [KO:K18985]
117539718  rock2a; LOW QUALITY PROTEIN: rho-associated protein kinase 2 [KO:K17388] [EC:2.7.11.1]
117556533  rho-associated protein kinase 2-like isoform X1 [KO:K17388] [EC:2.7.11.1]
117539054  myl2b; myosin, light chain 2b, regulatory, cardiac, slow [KO:K10351]
117561898  myl2a; myosin regulatory light chain 2, ventricular/cardiac muscle isoform [KO:K10351]
117560275  myl7; myosin regulatory light chain 2, atrial isoform [KO:K12754]
117533412  myl9b; myosin regulatory light polypeptide 9b [KO:K12755]
117544682  myl12.1; myosin, light chain 12, genome duplicate 1 [KO:K12757]
117542174  myl12.2; myosin, light chain 12, genome duplicate 2 isoform X1 [KO:K12757]
117545032  mylpfb; myosin light chain, phosphorylatable, fast skeletal muscle b [KO:K12758]
117548336  mylpfa; myosin light chain, phosphorylatable, fast skeletal muscle a [KO:K12758]
117555485  si:ch211-63p21.2; FH1/FH2 domain-containing protein 1 isoform X1 [KO:K23938]
117551817  cdc42l; cell division cycle 42, like [KO:K04393]
117545363  cell division control protein 42 homolog [KO:K04393]
117542978  cell division control protein 42 homolog isoform X1 [KO:K04393]
117559500  cell division control protein 42 homolog [KO:K04393]
117544903  rac1a; ras-related C3 botulinum toxin substrate 1 isoform X1 [KO:K04392]
117548381  rac1b; ras-related C3 botulinum toxin substrate 1b [KO:K04392]
117534229  nckap1l; nck-associated protein 1-like [KO:K05750]
117545218  cyfip2; cytoplasmic FMR1-interacting protein 2 isoform X1 [KO:K05749]
117546806  cyfip1; LOW QUALITY PROTEIN: cytoplasmic FMR1-interacting protein 1 homolog [KO:K05749]
117544683  abi1a; abl interactor 1a isoform X1 [KO:K23649]
117545419  abl interactor 1-like isoform X1 [KO:K23649]
117548123  brk1; probable protein BRICK1 [KO:K05752]
117541521  wiskott-Aldrich syndrome protein family member 3-like [KO:K06083]
117554998  wasf3b; LOW QUALITY PROTEIN: wiskott-Aldrich syndrome protein family member 3b [KO:K06083]
117536590  wiskott-Aldrich syndrome protein family member 3-like [KO:K06083]
117535147  actin-related protein 2-B [KO:K17260]
117542328  actin-related protein 2-B-like [KO:K17260]
117555489  zgc:101810; actin-related protein 2 [KO:K17260]
117550656  actin-related protein 3-like isoform X1 [KO:K18584]
117539357  actin-related protein 3 [KO:K18584]
117547588  actin-related protein 3-like isoform X1 [KO:K18584]
117551499  zgc:86896; actin-related protein 2/3 complex subunit 1A-A [KO:K05757]
117556212  arpc1a; actin-related protein 2/3 complex subunit 1A [KO:K05757]
117556221  arpc1b; actin-related protein 2/3 complex subunit 1B [KO:K05757]
117546642  arpc2; actin-related protein 2/3 complex subunit 2 [KO:K05758]
117534072  arpc3; actin-related protein 2/3 complex subunit 3 [KO:K05756]
117543712  actin-related protein 2/3 complex subunit 4-like [KO:K05755]
117551057  arpc4; actin-related protein 2/3 complex subunit 4 [KO:K05755]
117542441  arpc5b; actin-related protein 2/3 complex subunit 5b [KO:K05754]
117560688  pak1; serine/threonine-protein kinase PAK 1 [KO:K04409] [EC:2.7.11.1]
117535474  serine/threonine-protein kinase PAK 3 isoform X1 [KO:K05733] [EC:2.7.11.1]
117550050  myo6b; myosin VIb isoform X1 [KO:K10358]
117545508  phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform [KO:K00922] [EC:2.7.1.153]
117534275  pik3cb; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform isoform X1 [KO:K00922] [EC:2.7.1.153]
117541887  pik3cd; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform [KO:K00922] [EC:2.7.1.153]
117542378  phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform-like isoform X1 [KO:K00922] [EC:2.7.1.153]
117552533  pik3cg; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform [KO:K21289] [EC:2.7.1.153]
117547700  si:rp71-17i16.5; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform [KO:K21289] [EC:2.7.1.153]
117557463  pik3c2a; phosphatidylinositol 4-phosphate 3-kinase C2 domain-containing subunit alpha [KO:K00923] [EC:2.7.1.154]
117538957  pik3c2g; phosphatidylinositol 4-phosphate 3-kinase C2 domain-containing subunit gamma isoform X1 [KO:K00923] [EC:2.7.1.154]
117544378  cyth1b; cytohesin-1b isoform X1 [KO:K18441]
117533458  si:dkey-283b15.4; cytohesin-2 [KO:K18441]
117545133  LOW QUALITY PROTEIN: cytohesin-3-like [KO:K18441]
117541428  cytohesin-4-like isoform X1 [KO:K18441]
117548348  cyth1a; cytohesin-1a isoform X1 [KO:K18441]
117548543  cyth3b; cytohesin-3 isoform X1 [KO:K18441]
117548812  cytohesin-3-like isoform X1 [KO:K18441]
117554179  arf6a; ADP-ribosylation factor 6a [KO:K07941]
117550047  arf6b; LOW QUALITY PROTEIN: ADP-ribosylation factor 6b [KO:K07941]
117553535  ADP-ribosylation factor 1 [KO:K07937]
117548441  arf2a; ADP-ribosylation factor 2a [KO:K07937]
117558477  arf1; ADP-ribosylation factor 1 [KO:K07937]
117533764  snx9b; sorting nexin-9b [KO:K17923]
117554791  sorting nexin-18-like [KO:K17923]
117559392  snx33; sorting nexin-33 isoform X1 [KO:K17923]
117560178  snx18a; sorting nexin-18a [KO:K17923]
117551022  si:dkey-197j19.6; wiskott-Aldrich syndrome protein isoform X1 [KO:K23612]
117535980  LOW QUALITY PROTEIN: neural Wiskott-Aldrich syndrome protein-like [KO:K23612]
117562791  LOW QUALITY PROTEIN: neural Wiskott-Aldrich syndrome protein-like [KO:K23612]
117548658  dnm2a; dynamin-3 isoform X1 [KO:K23484] [EC:3.6.5.5]
117561571  dynamin-2-like isoform X1 [KO:K23484] [EC:3.6.5.5]
117547155  toll-like receptor 1 [KO:K10169]
117553624  LOW QUALITY PROTEIN: toll-like receptor 2 [KO:K10159]
117556193  toll-like receptor 2 [KO:K10159]
117563201  tlr18; toll-like receptor 18 [KO:K10159]
117551687  tirap; toll/interleukin-1 receptor domain-containing adapter protein [KO:K05403]
117549862  myeloid differentiation primary response protein MyD88-like [KO:K04729]
117532795  toll-like receptor 5 [KO:K10168]
117554374  toll-like receptor 5 isoform X1 [KO:K10168]
117547837  irak4; interleukin-1 receptor-associated kinase 4 isoform X1 [KO:K04733] [EC:2.7.11.1]
117549320  traf6; TNF receptor-associated factor 6 [KO:K03175] [EC:2.3.2.27]
117538648  map3k7; mitogen-activated protein kinase kinase kinase 7 isoform X1 [KO:K04427] [EC:2.7.11.25]
117536277  mitogen-activated protein kinase kinase kinase 7-like [KO:K04427] [EC:2.7.11.25]
117555242  tab1; TGF-beta-activated kinase 1 and MAP3K7-binding protein 1 isoform X1 [KO:K04403]
117538684  tab2; TGF-beta-activated kinase 1 and MAP3K7-binding protein 2 [KO:K04404]
117555112  tab3; LOW QUALITY PROTEIN: TGF-beta-activated kinase 1 and MAP3K7-binding protein 3 [KO:K12793]
117541485  ikbkg; NF-kappa-B essential modulator isoform X1 [KO:K07210]
117536794  inhibitor of nuclear factor kappa-B kinase subunit alpha-like isoform X1 [KO:K04467] [EC:2.7.11.10]
117547053  inhibitor of nuclear factor kappa-B kinase subunit alpha-like [KO:K04467] [EC:2.7.11.10]
117560475  ikbkb; inhibitor of nuclear factor kappa-B kinase subunit beta [KO:K07209] [EC:2.7.11.10]
117539703  nfkbiab; LOW QUALITY PROTEIN: nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha b [KO:K04734]
117554163  nfkbiaa; nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha a [KO:K04734]
117542722  rela; transcription factor p65 isoform X1 [KO:K04735]
117546850  nod1; LOW QUALITY PROTEIN: nucleotide-binding oligomerization domain-containing protein 1 [KO:K08727]
117554258  hsp90aa1.2; heat shock protein 90, alpha (cytosolic), class A member 1, tandem duplicate 2 isoform X1 [KO:K04079]
117562329  hsp90ab1; heat shock protein HSP 90-beta [KO:K04079]
117538900  hsp90b1; endoplasmin [KO:K09487]
117545636  ripk2; receptor-interacting serine/threonine-protein kinase 2 [KO:K08846] [EC:2.7.11.1]
117551119  cse1l; exportin-2 [KO:K18423]
117535860  kpna1; importin subunit alpha-5 isoform X1 [KO:K23940]
117544569  kpna3; importin subunit alpha-4 isoform X1 [KO:K23583]
117554814  kpna4; importin subunit alpha-3 [KO:K23583]
117560682  rps3; 40S ribosomal protein S3 [KO:K02985]
117545900  GTPase HRas [KO:K02833]
117542983  raf1a; raf-1 proto-oncogene, serine/threonine kinase a isoform X1 [KO:K04366] [EC:2.7.11.1]
117538865  map2k1; dual specificity mitogen-activated protein kinase kinase 1 [KO:K04368] [EC:2.7.12.2]
117532733  map2k2b; dual specificity mitogen-activated protein kinase kinase 2b [KO:K04369] [EC:2.7.12.2]
117546153  map2k2a; dual specificity mitogen-activated protein kinase kinase 2a [KO:K04369] [EC:2.7.12.2]
117544100  mapk3; mitogen-activated protein kinase 3 [KO:K04371] [EC:2.7.11.24]
117546425  mapk1; mitogen-activated protein kinase 1 [KO:K04371] [EC:2.7.11.24]
117553527  map2k6; dual specificity mitogen-activated protein kinase kinase 6 [KO:K04433] [EC:2.7.12.2]
117548594  dual specificity mitogen-activated protein kinase kinase 6-like [KO:K04433] [EC:2.7.12.2]
117550850  mapk12a; mitogen-activated protein kinase 12 [KO:K04441] [EC:2.7.11.24]
117532852  mapk13; mitogen-activated protein kinase 13 [KO:K04441] [EC:2.7.11.24]
117532885  zgc:171775; STKc_p38 domain-containing protein [KO:K04441] [EC:2.7.11.24]
117547509  mapk14b; LOW QUALITY PROTEIN: mitogen-activated protein kinase 14B [KO:K04441] [EC:2.7.11.24]
117541966  mapk14a; mitogen-activated protein kinase 14A isoform X1 [KO:K04441] [EC:2.7.11.24]
117562573  mapk11; mitogen-activated protein kinase 11 [KO:K04441] [EC:2.7.11.24]
117562577  mitogen-activated protein kinase 12-like [KO:K04441] [EC:2.7.11.24]
117536890  map2k4a; dual specificity mitogen-activated protein kinase kinase 4a isoform X1 [KO:K04430] [EC:2.7.12.2]
117552371  map2k4b; dual specificity mitogen-activated protein kinase kinase 4b isoform X1 [KO:K04430] [EC:2.7.12.2]
117537936  map2k7; dual specificity mitogen-activated protein kinase kinase 7 isoform X1 [KO:K04431] [EC:2.7.12.2]
117536791  mapk8a; mitogen-activated protein kinase 8 isoform X1 [KO:K04440] [EC:2.7.11.24]
117532364  mapk8b; LOW QUALITY PROTEIN: mitogen-activated protein kinase 8 [KO:K04440] [EC:2.7.11.24]
117551262  mapk10; mitogen-activated protein kinase 10 isoform X1 [KO:K04440] [EC:2.7.11.24]
117555963  mapk9; mitogen-activated protein kinase 9 [KO:K04440] [EC:2.7.11.24]
117533795  fosab; v-fos FBJ murine osteosarcoma viral oncogene homolog Ab [KO:K04379]
117533803  proto-oncogene c-Fos-like [KO:K04379]
117549989  fosaa; proto-oncogene c-Fos [KO:K04379]
117557427  june; LOW QUALITY PROTEIN: junE proto-oncogene, AP-1 transcription factor subunit [KO:K04448]
117545557  transcription factor AP-1-like [KO:K04448]
117555214  jun; transcription factor AP-1 [KO:K04448]
117535957  tumor necrosis factor-like [KO:K03156]
117546446  interleukin-1 beta-like [KO:K04519]
117562823  interleukin-6-like [KO:K05405]
117555523  cxcl19; C-X-C motif chemokine 19 [KO:K10030]
117543405  interleukin-8-like [KO:K10030]
117540803  ctnnb1; catenin beta-1 [KO:K02105]
117562919  catenin beta-1-like [KO:K02105]
117540208  tcf7; transcription factor 7 isoform X1 [KO:K02620]
117556347  transcription factor 7-like 1-A [KO:K04490]
117561075  tcf7l1b; transcription factor 7-like 1-B isoform X1 [KO:K04490]
117543165  tcf7l2; LOW QUALITY PROTEIN: transcription factor 7-like 2 [KO:K04491]
117544662  myca; transcriptional regulator Myc-A [KO:K04377]
117534628  transcriptional regulator Myc-like [KO:K04377]
117537951  pkn1a; serine/threonine-protein kinase N1 isoform X1 [KO:K06071] [EC:2.7.11.13]
117538322  pkn1b; serine/threonine-protein kinase N1b isoform X1 [KO:K06071] [EC:2.7.11.13]
117556713  fbxo22; F-box only protein 22 [KO:K10302]
117540209  skp1; S-phase kinase-associated protein 1 isoform X1 [KO:K03094]
117548000  tnfrsf1a; tumor necrosis factor receptor superfamily member 1A [KO:K03158]
117541843  si:ch211-112c15.8; tumor necrosis factor receptor superfamily member 1A [KO:K03158]
117538173  traf2b; TNF receptor-associated factor 2 [KO:K03173] [EC:2.3.2.27]
117534956  TNF receptor-associated factor 2-like isoform X1 [KO:K03173] [EC:2.3.2.27]
117561444  TNF receptor-associated factor 2-like [KO:K03173] [EC:2.3.2.27]
117533310  tradd; tumor necrosis factor receptor type 1-associated DEATH domain protein [KO:K03171]
117536004  birc2; baculoviral IAP repeat-containing protein 2 isoform X1 [KO:K16060]
117558314  ripk1l; receptor-interacting serine/threonine-protein kinase 1 [KO:K02861] [EC:2.7.11.1]
117545359  glyceraldehyde-3-phosphate dehydrogenase-like [KO:K00134] [EC:1.2.1.12]
117548006  gapdh; glyceraldehyde-3-phosphate dehydrogenase [KO:K00134] [EC:1.2.1.12]
117537879  tumor necrosis factor ligand superfamily member 10-like [KO:K04721]
117558767  tumor necrosis factor ligand superfamily member 10-like [KO:K04721]
117538258  tumor necrosis factor receptor superfamily member 1A-like [KO:K04722]
117562217  tnfrsfa; tumor necrosis factor receptor superfamily, member a [KO:K04722]
117534615  fadd; FAS-associated death domain protein [KO:K02373]
117544401  casp10; caspase-8 isoform X1 [KO:K04398] [EC:3.4.22.61]
117533360  caspase-8-like [KO:K04398] [EC:3.4.22.61]
117546044  LOW QUALITY PROTEIN: caspase-8-like [KO:K04398] [EC:3.4.22.61]
117556610  casp8; caspase-8 isoform X1 [KO:K04398] [EC:3.4.22.61]
117556611  caspase-8-like [KO:K04398] [EC:3.4.22.61]
117545770  ankyrin repeat and protein kinase domain-containing protein 1-like isoform X1 [KO:K08847] [EC:2.7.11.1]
117536371  LOW QUALITY PROTEIN: receptor-interacting serine/threonine-protein kinase 3-like [KO:K08847] [EC:2.7.11.1]
117534621  zgc:153993; apoptosis regulator BAX [KO:K02159]
117548746  apoptosis regulator BAX-like [KO:K02159]
117544313  cytochrome c [KO:K08738]
117551848  cytochrome c [KO:K08738]
117563018  cytochrome c-a [KO:K08738]
117558349  bcl2b; apoptosis regulator Bcl-2 [KO:K02161]
117550380  caspase-3-like [KO:K02187] [EC:3.4.22.56]
117556108  casp3a; caspase-3a [KO:K02187] [EC:3.4.22.56]
117544914  casp7; caspase-7 [KO:K04397] [EC:3.4.22.60]
117546830  caspase-7-like [KO:K04397] [EC:3.4.22.60]
117556777  rho-related GTP-binding protein RhoB-like [KO:K07856]
117543379  rhoh; rho-related GTP-binding protein RhoH [KO:K07873]
117544558  LOW QUALITY PROTEIN: RAC-beta serine/threonine-protein kinase-like [KO:K04456] [EC:2.7.11.1]
117551707  akt2; RAC-beta serine/threonine-protein kinase [KO:K04456] [EC:2.7.11.1]
117550034  akt1; LOW QUALITY PROTEIN: RAC-alpha serine/threonine-protein kinase [KO:K04456] [EC:2.7.11.1]
117560397  RAC-gamma serine/threonine-protein kinase-like [KO:K04456] [EC:2.7.11.1]
117560747  akt3a; LOW QUALITY PROTEIN: RAC-gamma serine/threonine-protein kinase [KO:K04456] [EC:2.7.11.1]
117541047  mixed lineage kinase domain-like protein [KO:K08849] [EC:2.7.11.1]
117538318  txn2; thioredoxin, mitochondrial isoform X1 [KO:K03671]
117539169  txn; thioredoxin [KO:K03671]
117539184  thioredoxin-like [KO:K03671]
117536338  apoptosis-associated speck-like protein containing a CARD isoform X1 [KO:K12799]
117543206  apoptosis-associated speck-like protein containing a CARD [KO:K12799]
117554819  LOW QUALITY PROTEIN: caspase-1-like [KO:K01370] [EC:3.4.22.36]
Compound
C00338  Lipopolysaccharide
C01194  1-Phosphatidyl-D-myo-inositol
C04549  1-Phosphatidyl-1D-myo-inositol 3-phosphate
C05981  Phosphatidylinositol-3,4,5-trisphosphate
C11554  1-Phosphatidyl-1D-myo-inositol 3,4-bisphosphate
Reference
PMID:28875943
  Authors
Bernal-Bayard J, Ramos-Morales F
  Title
Molecular Mechanisms Used by Salmonella to Evade the Immune System.
  Journal
Curr Issues Mol Biol 25:133-168 (2018)
DOI:10.21775/cimb.025.133
Reference
PMID:28848711
  Authors
Hume PJ, Singh V, Davidson AC, Koronakis V
  Title
Swiss Army Pathogen: The Salmonella Entry Toolkit.
  Journal
Front Cell Infect Microbiol 7:348 (2017)
DOI:10.3389/fcimb.2017.00348
Reference
PMID:31402916
  Authors
Wemyss MA, Pearson JS
  Title
Host Cell Death Responses to Non-typhoidal Salmonella Infection.
  Journal
Front Immunol 10:1758 (2019)
DOI:10.3389/fimmu.2019.01758
Reference
PMID:27974148
  Authors
Bierschenk D, Boucher D, Schroder K
  Title
Salmonella-induced inflammasome activation in humans.
  Journal
Mol Immunol 86:38-43 (2017)
DOI:10.1016/j.molimm.2016.11.009
Reference
PMID:29477730
  Authors
Pinaud L, Sansonetti PJ, Phalipon A
  Title
Host Cell Targeting by Enteropathogenic Bacteria T3SS Effectors.
  Journal
Trends Microbiol 26:266-283 (2018)
DOI:10.1016/j.tim.2018.01.010
Reference
PMID:25749450
  Authors
LaRock DL, Chaudhary A, Miller SI
  Title
Salmonellae interactions with host processes.
  Journal
Nat Rev Microbiol 13:191-205 (2015)
DOI:10.1038/nrmicro3420
Reference
PMID:17983751
  Authors
Ramsden AE, Holden DW, Mota LJ
  Title
Membrane dynamics and spatial distribution of Salmonella-containing vacuoles.
  Journal
Trends Microbiol 15:516-24 (2007)
DOI:10.1016/j.tim.2007.10.002
Reference
PMID:22702524
  Authors
van der Heijden J, Finlay BB
  Title
Type III effector-mediated processes in Salmonella infection.
  Journal
Future Microbiol 7:685-703 (2012)
DOI:10.2217/fmb.12.49
Reference
PMID:27222578
  Authors
Galan JE
  Title
Typhoid toxin provides a window into typhoid fever and the biology of Salmonella Typhi.
  Journal
Proc Natl Acad Sci U S A 113:6338-44 (2016)
DOI:10.1073/pnas.1606335113
Reference
PMID:19157959
  Authors
McGhie EJ, Brawn LC, Hume PJ, Humphreys D, Koronakis V
  Title
Salmonella takes control: effector-driven manipulation of the host.
  Journal
Curr Opin Microbiol 12:117-24 (2009)
DOI:10.1016/j.mib.2008.12.001
Reference
PMID:12675800
  Authors
Miao EA, Brittnacher M, Haraga A, Jeng RL, Welch MD, Miller SI
  Title
Salmonella effectors translocated across the vacuolar membrane interact with the actin cytoskeleton.
  Journal
Mol Microbiol 48:401-15 (2003)
DOI:10.1046/j.1365-2958.2003.t01-1-03456.x
Reference
PMID:17074883
  Authors
Patel JC, Galan JE
  Title
Differential activation and function of Rho GTPases during Salmonella-host cell interactions.
  Journal
J Cell Biol 175:453-63 (2006)
DOI:10.1083/jcb.200605144
Reference
PMID:18411289
  Authors
Wasylnka JA, Bakowski MA, Szeto J, Ohlson MB, Trimble WS, Miller SI, Brumell JH
  Title
Role for myosin II in regulating positioning of Salmonella-containing vacuoles and intracellular replication.
  Journal
Infect Immun 76:2722-35 (2008)
DOI:10.1128/IAI.00152-08
Reference
PMID:10499590
  Authors
Fu Y, Galan JE
  Title
A salmonella protein antagonizes Rac-1 and Cdc42 to mediate host-cell recovery after bacterial invasion.
  Journal
Nature 401:293-7 (1999)
DOI:10.1038/45829
Related
pathway
gacu04010  MAPK signaling pathway
gacu04210  Apoptosis
gacu04217  Necroptosis
gacu04621  NOD-like receptor signaling pathway
KO pathway
ko05132   
LinkDB

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