KEGG   PATHWAY: hai05152
Entry
hai05152                    Pathway                                
Name
Tuberculosis - Hipposideros armiger (great roundleaf bat)
Description
Tuberculosis, or TB, is an infectious disease caused by Mycobacterium tuberculosis. One third of the world's population is thought to be infected with TB. About 90% of those infected result in latent infections, and about 10% of latent infections develop active diseases when their immune system is impaired due to the age, other diseases such as AIDS or exposure to immunosuppressive drugs. TB is transmitted through the air and primarily attacks the lungs, then it can spread by the circulatory system to other parts of body. Once TB bacilli have entered the host by the respiratory route and infected macrophages in the lungs, they interfere with phagosomal maturation, antigen presentation, apoptosis and host immune system to establish persistent or latent infection.
Class
Human Diseases; Infectious disease: bacterial
Pathway map
hai05152  Tuberculosis
hai05152

Organism
Hipposideros armiger (great roundleaf bat) [GN:hai]
Gene
109373073  TNF; tumor necrosis factor isoform X1 [KO:K03156]
109373644  TNFRSF1A; tumor necrosis factor receptor superfamily member 1A [KO:K03158]
109390108  TRADD; tumor necrosis factor receptor type 1-associated DEATH domain protein isoform X1 [KO:K03171]
109389315  FADD; FAS-associated death domain protein [KO:K02373]
109379228  CASP8; caspase-8 [KO:K04398] [EC:3.4.22.61]
109379185  CASP10; caspase-10 [KO:K04400] [EC:3.4.22.63]
109395706  CASP3; caspase-3 isoform X1 [KO:K02187] [EC:3.4.22.56]
109373303  BID; BH3-interacting domain death agonist [KO:K04726]
109391068  BAX; apoptosis regulator BAX [KO:K02159]
109393551  cytochrome c [KO:K08738]
109381354  cytochrome c [KO:K08738]
109381302  CASP9; caspase-9 isoform X1 [KO:K04399] [EC:3.4.22.62]
109382336  APAF1; apoptotic protease-activating factor 1 isoform X1 [KO:K02084]
109381083  AKT1; RAC-alpha serine/threonine-protein kinase [KO:K04456] [EC:2.7.11.1]
109385878  RAC-beta serine/threonine-protein kinase-like isoform X1 [KO:K04456] [EC:2.7.11.1]
109374859  AKT2; RAC-beta serine/threonine-protein kinase [KO:K04456] [EC:2.7.11.1]
109385353  AKT3; RAC-gamma serine/threonine-protein kinase isoform X1 [KO:K04456] [EC:2.7.11.1]
109384256  BAD; bcl2-associated agonist of cell death [KO:K02158]
109390784  BCL2; apoptosis regulator Bcl-2 isoform X1 [KO:K02161]
109372542  CAMK2G; calcium/calmodulin-dependent protein kinase type II subunit gamma isoform X1 [KO:K04515] [EC:2.7.11.17]
109373019  CAMK2B; calcium/calmodulin-dependent protein kinase type II subunit beta isoform X1 [KO:K04515] [EC:2.7.11.17]
109375001  CAMK2A; calcium/calmodulin-dependent protein kinase type II subunit alpha isoform X1 [KO:K04515] [EC:2.7.11.17]
109390284  CAMK2D; calcium/calmodulin-dependent protein kinase type II subunit delta isoform X1 [KO:K04515] [EC:2.7.11.17]
109381671  IFNG; interferon gamma [KO:K04687]
109385640  IFNGR1; interferon gamma receptor 1 isoform X1 [KO:K05132]
109376141  LOW QUALITY PROTEIN: interferon gamma receptor 1-like [KO:K05132]
109373230  IFNGR2; interferon gamma receptor 2 [KO:K05133]
109384938  JAK1; tyrosine-protein kinase JAK1 [KO:K11217] [EC:2.7.10.2]
109384506  JAK2; tyrosine-protein kinase JAK2 isoform X1 [KO:K04447] [EC:2.7.10.2]
109393276  STAT1; signal transducer and activator of transcription 1-alpha/beta [KO:K11220]
109387149  CIITA; MHC class II transactivator isoform X1 [KO:K08060] [EC:2.7.11.1]
109372299  RFX5; DNA-binding protein RFX5 isoform X1 [KO:K08061]
109382506  RFXANK; DNA-binding protein RFXANK isoform X1 [KO:K08062]
109388472  RFXAP; regulatory factor X-associated protein [KO:K08063]
109393797  NFYA; nuclear transcription factor Y subunit alpha isoform X1 [KO:K08064]
109387755  NFYB; nuclear transcription factor Y subunit beta [KO:K08065]
109383387  NFYC; nuclear transcription factor Y subunit gamma isoform X1 [KO:K08066]
109388316  CREB1; cyclic AMP-responsive element-binding protein 1 isoform X1 [KO:K05870]
109373047  HLA class II histocompatibility antigen, DR alpha chain [KO:K06752]
109392411  HLA class II histocompatibility antigen, DP beta 1 chain [KO:K06752]
109392415  HLA class II histocompatibility antigen, DP alpha 1 chain [KO:K06752]
109378577  HLA class II histocompatibility antigen, DM beta chain [KO:K06752]
109373106  H-2 class II histocompatibility antigen, E-S beta chain [KO:K06752]
109373108  HLA class II histocompatibility antigen, DQ alpha 2 chain-like [KO:K06752]
109373109  HLA class II histocompatibility antigen, DQ beta 2 chain-like isoform X1 [KO:K06752]
109377860  HLA class II histocompatibility antigen, DQ beta 2 chain-like isoform X1 [KO:K06752]
109377861  HLA class II histocompatibility antigen, DQ beta 1 chain-like [KO:K06752]
109377862  H-2 class II histocompatibility antigen, A-F alpha chain-like [KO:K06752]
109377863  HLA class II histocompatibility antigen, DQ alpha 2 chain-like [KO:K06752]
109376897  SLA class II histocompatibility antigen, DQ haplotype D alpha chain-like [KO:K06752]
109376898  HLA class II histocompatibility antigen, DQ alpha 2 chain-like [KO:K06752]
109378434  HLA class II histocompatibility antigen, DM alpha chain [KO:K06752]
109378436  HLA class II histocompatibility antigen, DO alpha chain [KO:K06752]
109376891  SLA class II histocompatibility antigen, DQ haplotype C beta chain-like isoform X1 [KO:K06752]
109376893  rano class II histocompatibility antigen, A beta chain-like isoform X1 [KO:K06752]
109377864  SLA class II histocompatibility antigen, DQ haplotype D alpha chain-like [KO:K06752]
109378145  HLA class II histocompatibility antigen, DO beta chain-like isoform X1 [KO:K06752]
109376871  CD74; HLA class II histocompatibility antigen gamma chain isoform X1 [KO:K06505]
109392135  CREBBP; CREB-binding protein isoform X1 [KO:K04498] [EC:2.3.1.48]
109392262  EP300; histone acetyltransferase p300 isoform X1 [KO:K04498] [EC:2.3.1.48]
109374504  IL10; interleukin-10 [KO:K05443]
109385272  IL10RA; interleukin-10 receptor subunit alpha [KO:K05134]
109373232  IL10RB; interleukin-10 receptor subunit beta [KO:K05135]
109372254  CTSS; cathepsin S [KO:K01368] [EC:3.4.22.27]
109372743  C-type lectin domain family 4 member E-like isoform X1 [KO:K10059]
109376936  FCER1G; high affinity immunoglobulin epsilon receptor subunit gamma [KO:K07983]
109375255  C-type lectin domain family 7 member A-like [KO:K10074]
109377191  SRC; proto-oncogene tyrosine-protein kinase Src isoform X1 [KO:K05704] [EC:2.7.10.2]
109375897  SYK; tyrosine-protein kinase SYK isoform X1 [KO:K05855] [EC:2.7.10.2]
109381408  CARD9; caspase recruitment domain-containing protein 9 [KO:K12794]
109381749  MALT1; mucosa-associated lymphoid tissue lymphoma translocation protein 1 isoform X1 [KO:K07369] [EC:3.4.22.-]
109372895  BCL10; B-cell lymphoma/leukemia 10 [KO:K07368]
109383342  NOD2; nucleotide-binding oligomerization domain-containing protein 2 isoform X1 [KO:K10165]
109387588  RIPK2; receptor-interacting serine/threonine-protein kinase 2 [KO:K08846] [EC:2.7.11.1]
109393033  HSPA9; stress-70 protein, mitochondrial [KO:K04043]
109373302  LOW QUALITY PROTEIN: 60 kDa heat shock protein, mitochondrial-like [KO:K04077] [EC:5.6.1.7]
109372124  LBP; lipopolysaccharide-binding protein [KO:K05399]
109382017  TLR2; toll-like receptor 2 [KO:K10159]
109379481  TLR1; toll-like receptor 1 [KO:K05398]
109385740  TLR4; toll-like receptor 4 [KO:K10160]
109393398  CD14; monocyte differentiation antigen CD14 [KO:K04391]
109391405  TIRAP; toll/interleukin-1 receptor domain-containing adapter protein isoform X1 [KO:K05403]
109393491  MYD88; myeloid differentiation primary response protein MyD88 [KO:K04729]
109388403  IRAK4; interleukin-1 receptor-associated kinase 4 isoform X1 [KO:K04733] [EC:2.7.11.1]
109394352  IRAK1; interleukin-1 receptor-associated kinase 1 [KO:K04730] [EC:2.7.11.1]
109387293  VHL; von Hippel-Lindau disease tumor suppressor isoform X1 [KO:K04731] [EC:2.7.11.1]
109381153  TRAF6; TNF receptor-associated factor 6 isoform X1 [KO:K03175] [EC:2.3.2.27]
109372541  NFKB1; nuclear factor NF-kappa-B p105 subunit isoform X1 [KO:K02580]
109384322  RELA; transcription factor p65 isoform X1 [KO:K04735]
109395979  MAPK14; mitogen-activated protein kinase 14 isoform X1 [KO:K04441] [EC:2.7.11.24]
109395980  MAPK13; mitogen-activated protein kinase 13 isoform X1 [KO:K04441] [EC:2.7.11.24]
109396629  MAPK12; mitogen-activated protein kinase 12 isoform X1 [KO:K04441] [EC:2.7.11.24]
109396630  MAPK11; mitogen-activated protein kinase 11 isoform X1 [KO:K04441] [EC:2.7.11.24]
109385803  MAPK3; mitogen-activated protein kinase 3 isoform X1 [KO:K04371] [EC:2.7.11.24]
109394900  MAPK1; mitogen-activated protein kinase 1 [KO:K04371] [EC:2.7.11.24]
109392215  MAPK8; mitogen-activated protein kinase 8 isoform X1 [KO:K04440] [EC:2.7.11.24]
109377948  mitogen-activated protein kinase 10 [KO:K04440] [EC:2.7.11.24]
109392748  MAPK9; mitogen-activated protein kinase 9 [KO:K04440] [EC:2.7.11.24]
109385084  NOS2; nitric oxide synthase, inducible isoform X1 [KO:K13241] [EC:1.14.13.39]
109387871  IL6; interleukin-6 [KO:K05405]
109373148  IL12A; LOW QUALITY PROTEIN: interleukin-12 subunit alpha [KO:K05406]
109388897  IL12B; interleukin-12 subunit beta [KO:K05425]
109388707  IL18; interleukin-18 [KO:K05482]
109396832  IL23A; interleukin-23 subunit alpha [KO:K05426]
109393526  IL1A; interleukin-1 alpha [KO:K04383]
109393524  IL1B; interleukin-1 beta isoform X1 [KO:K04519]
109381855  CEBPB; CCAAT/enhancer-binding protein beta [KO:K10048]
109389206  CEBPG; CCAAT/enhancer-binding protein gamma [KO:K10049]
109375839  toll-like receptor 9 isoform X1 [KO:K10161]
109374670  interferon alpha-4-like [KO:K05414]
109396418  IFNB1; interferon beta [KO:K05415]
109396070  CD209; CD209 antigen [KO:K06563]
109396071  CD209 antigen-like protein 2 isoform X1 [KO:K06563]
109396074  CD209 antigen-like protein 2 [KO:K06563]
109393895  ARHGEF12; rho guanine nucleotide exchange factor 12 isoform X1 [KO:K07532]
109376114  RHOA; transforming protein RhoA isoform X1 [KO:K04513]
109395928  LSP1; lymphocyte-specific protein 1 isoform X1 [KO:K14957]
109383334  PLK3; serine/threonine-protein kinase PLK3 [KO:K08862] [EC:2.7.11.21]
109385115  KSR1; kinase suppressor of Ras 1 isoform X1 [KO:K14958]
109384548  RAF1; RAF proto-oncogene serine/threonine-protein kinase isoform X1 [KO:K04366] [EC:2.7.11.1]
109376590  TGFB1; transforming growth factor beta-1 [KO:K13375]
109381205  TGFB2; transforming growth factor beta-2 isoform X1 [KO:K13376]
109381619  TGFB3; transforming growth factor beta-3 isoform X1 [KO:K13377]
109390756  25-hydroxyvitamin D-1 alpha hydroxylase, mitochondrial [KO:K07438] [EC:1.14.15.18]
109372509  VDR; vitamin D3 receptor [KO:K08539]
109375616  CAMP; cathelicidin antimicrobial peptide [KO:K13916]
109377857  CR1; complement receptor type 1 isoform X1 [KO:K04011]
109372101  ITGB2; integrin beta-2 [KO:K06464]
109374167  integrin alpha-M-like isoform X1 [KO:K06461]
109379836  PLA2R1; secretory phospholipase A2 receptor isoform X1 [KO:K06560]
109380338  MRC2; C-type mannose receptor 2 isoform X1 [KO:K06560]
109393568  MRC1; macrophage mannose receptor 1 [KO:K06560]
109391059  SPHK2; sphingosine kinase 2 isoform X1 [KO:K04718] [EC:2.7.1.91]
109383749  SPHK1; sphingosine kinase 1 isoform X1 [KO:K04718] [EC:2.7.1.91]
109382670  CALM1; calmodulin [KO:K02183]
109380340  calmodulin-like [KO:K02183]
109391149  CALML6; calmodulin-like protein 6 [KO:K02183]
109383794  calmodulin-like protein 3 [KO:K02183]
109383796  calmodulin-like [KO:K02183]
109372230  CALM3; calmodulin [KO:K02183]
109389917  CALM2; calmodulin [KO:K02183]
109380396  PIK3C3; phosphatidylinositol 3-kinase catalytic subunit type 3 [KO:K00914] [EC:2.7.1.137]
109393991  RAB5A; ras-related protein Rab-5A [KO:K07887]
109396876  RAB5B; ras-related protein Rab-5B isoform X1 [KO:K07888]
109395780  RAB5C; ras-related protein Rab-5C [KO:K07889]
109371977  EEA1; early endosome antigen 1 isoform X1 [KO:K12478]
109377415  RAB7A; ras-related protein Rab-7a [KO:K07897]
109395931  CTSD; cathepsin D [KO:K01379] [EC:3.4.23.5]
109386107  ATP6V0A2; V-type proton ATPase 116 kDa subunit a [KO:K02154]
109388515  V-type proton ATPase 116 kDa subunit a-like [KO:K02154]
109389291  TCIRG1; V-type proton ATPase 116 kDa subunit a isoform X1 [KO:K02154]
109395731  ATP6V0A1; V-type proton ATPase 116 kDa subunit a [KO:K02154]
109389861  ATP6V0D1; V-type proton ATPase subunit d 1 isoform X1 [KO:K02146]
109387584  ATP6V0D2; V-type proton ATPase subunit d 2 [KO:K02146]
109374432  ATP6V1H; V-type proton ATPase subunit H [KO:K02144]
109377345  ATP6AP1; V-type proton ATPase subunit S1 [KO:K03662]
109385920  ATP6V0C; V-type proton ATPase 16 kDa proteolipid subunit [KO:K02155]
109383428  ATP6V0B; V-type proton ATPase 21 kDa proteolipid subunit isoform X1 [KO:K03661]
109377057  LAMP2; lysosome-associated membrane glycoprotein 2 [KO:K06528]
109383954  LAMP1; lysosome-associated membrane glycoprotein 1 isoform X1 [KO:K06528]
109372443  PPP3CB; serine/threonine-protein phosphatase 2B catalytic subunit beta isoform isoform X1 [KO:K04348] [EC:3.1.3.16]
109392365  PPP3CA; serine/threonine-protein phosphatase 2B catalytic subunit alpha isoform isoform X1 [KO:K04348] [EC:3.1.3.16]
109375958  PPP3CC; serine/threonine-protein phosphatase 2B catalytic subunit gamma isoform isoform X1 [KO:K04348] [EC:3.1.3.16]
109379237  PPP3R1; calcineurin subunit B type 1 [KO:K06268]
109385802  CORO1A; coronin-1A [KO:K13882]
109378026  LOW QUALITY PROTEIN: high affinity immunoglobulin gamma Fc receptor I-like [KO:K06498]
109392296  FCGR2B; low affinity immunoglobulin gamma Fc region receptor II-b isoform X1 [KO:K12560]
109392302  uncharacterized protein LOC109392302 [KO:K06463]
Compound
C00076  Calcium cation
C00338  Lipopolysaccharide
C01194  1-Phosphatidyl-D-myo-inositol
C01561  Calcidiol
C01673  Calcitriol
C04549  1-Phosphatidyl-1D-myo-inositol 3-phosphate
C06124  Sphingosine 1-phosphate
C19190  Trehalose-6,6'-dibehenate
C21790  Mycobacterial trehalose dimycolate
G13101  Lipomannan
G13105  Triacylated phosphatidyl-myo-inositol pentamannoside
G13106  Triacylated phosphatidyl-myo-inositol hexamannoside
G13108  Triacylated phosphatidyl-myo-inositol dimannoside
G13109  Tetraacylated phosphatidyl-myo-inositol dimannoside
G13112  Tetraacylated phosphatidyl-myo-inositol hexamannoside
G13113  Tetraacylated phosphatidyl-myo-inositol pentamannoside
G13114  Lipoarabinomannan
G13115  Mannose-capped lipoarabinomannan
Reference
PMID:21274449
  Authors
Saiga H, Shimada Y, Takeda K
  Title
Innate immune effectors in mycobacterial infection.
  Journal
Clin Dev Immunol 2011:347594 (2011)
DOI:10.1155/2011/347594
Reference
PMID:20415982
  Authors
Dheda K, Schwander SK, Zhu B, van Zyl-Smit RN, Zhang Y
  Title
The immunology of tuberculosis: from bench to bedside.
  Journal
Respirology 15:433-50 (2010)
DOI:10.1111/j.1440-1843.2010.01739.x
Reference
PMID:11932234
  Authors
van Crevel R, Ottenhoff TH, van der Meer JW
  Title
Innate immunity to Mycobacterium tuberculosis.
  Journal
Clin Microbiol Rev 15:294-309 (2002)
DOI:10.1128/CMR.15.2.294-309.2002
Reference
PMID:18288961
  Authors
Torrelles JB, Azad AK, Henning LN, Carlson TK, Schlesinger LS
  Title
Role of C-type lectins in mycobacterial infections.
  Journal
Curr Drug Targets 9:102-12 (2008)
DOI:10.2174/138945008783502467
Reference
PMID:17359235
  Authors
Jo EK, Yang CS, Choi CH, Harding CV
  Title
Intracellular signalling cascades regulating innate immune responses to Mycobacteria: branching out from Toll-like receptors.
  Journal
Cell Microbiol 9:1087-98 (2007)
DOI:10.1111/j.1462-5822.2007.00914.x
Reference
PMID:21274433
  Authors
Marakalala MJ, Graham LM, Brown GD
  Title
The role of Syk/CARD9-coupled C-type lectin receptors in immunity to Mycobacterium tuberculosis infections.
  Journal
Clin Dev Immunol 2010:567571 (2010)
DOI:10.1155/2010/567571
Reference
PMID:15083155
  Authors
Koul A, Herget T, Klebl B, Ullrich A
  Title
Interplay between mycobacteria and host signalling pathways.
  Journal
Nat Rev Microbiol 2:189-202 (2004)
DOI:10.1038/nrmicro840
Reference
PMID:20199890
  Authors
Torrelles JB, Schlesinger LS
  Title
Diversity in Mycobacterium tuberculosis mannosylated cell wall determinants impacts adaptation to the host.
  Journal
Tuberculosis (Edinb) 90:84-93 (2010)
DOI:10.1016/j.tube.2010.02.003
Reference
PMID:15228522
  Authors
Briken V, Porcelli SA, Besra GS, Kremer L
  Title
Mycobacterial lipoarabinomannan and related lipoglycans: from biogenesis to modulation of the immune response.
  Journal
Mol Microbiol 53:391-403 (2004)
DOI:10.1111/j.1365-2958.2004.04183.x
Reference
PMID:19563525
  Authors
Baena A, Porcelli SA
  Title
Evasion and subversion of antigen presentation by Mycobacterium tuberculosis.
  Journal
Tissue Antigens 74:189-204 (2009)
DOI:10.1111/j.1399-0039.2009.01301.x
Reference
PMID:19369951
  Authors
Flannagan RS, Cosio G, Grinstein S
  Title
Antimicrobial mechanisms of phagocytes and bacterial evasion strategies.
  Journal
Nat Rev Microbiol 7:355-66 (2009)
DOI:10.1038/nrmicro2128
Reference
PMID:18541216
  Authors
Pieters J
  Title
Mycobacterium tuberculosis and the macrophage: maintaining a balance.
  Journal
Cell Host Microbe 3:399-407 (2008)
DOI:10.1016/j.chom.2008.05.006
Reference
PMID:19634703
  Authors
Scherr N, Jayachandran R, Mueller P, Pieters J
  Title
Interference of Mycobacterium tuberculosis with macrophage responses.
  Journal
Indian J Exp Biol 47:401-6 (2009)
Reference
PMID:16200082
  Authors
Reith W, LeibundGut-Landmann S, Waldburger JM.
  Title
Regulation of MHC class II gene expression by the class II transactivator.
  Journal
Nat Rev Immunol 5:793-806 (2005)
DOI:10.1038/nri1708
Reference
PMID:17785780
  Authors
Rothfuchs AG, Bafica A, Feng CG, Egen JG, Williams DL, Brown GD, Sher A
  Title
Dectin-1 interaction with Mycobacterium tuberculosis leads to enhanced IL-12p40 production by splenic dendritic cells.
  Journal
J Immunol 179:3463-71 (2007)
DOI:10.4049/jimmunol.179.6.3463
Reference
PMID:18407066
  Authors
Master SS, Rampini SK, Davis AS, Keller C, Ehlers S, Springer B, Timmins GS, Sander P, Deretic V
  Title
Mycobacterium tuberculosis prevents inflammasome activation.
  Journal
Cell Host Microbe 3:224-32 (2008)
DOI:10.1016/j.chom.2008.03.003
Reference
PMID:11378475
  Authors
Shtrichman R, Samuel CE
  Title
The role of gamma interferon in antimicrobial immunity.
  Journal
Curr Opin Microbiol 4:251-9 (2001)
DOI:10.1016/S1369-5274(00)00199-5
Related
pathway
hai04010  MAPK signaling pathway
hai04210  Apoptosis
hai04612  Antigen processing and presentation
hai04620  Toll-like receptor signaling pathway
hai04621  NOD-like receptor signaling pathway
hai04630  JAK-STAT signaling pathway
KO pathway
ko05152   
LinkDB

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