KEGG   PATHWAY: hai05168
Entry
hai05168                    Pathway                                
Name
Herpes simplex virus 1 infection - Hipposideros armiger (great roundleaf bat)
Description
Herpes simplex virus 1(HSV-1) is a common human pathogen, which initially infects orofacial mucosal surfaces. The virus replicates in epithelial cells at these sites, causing clinically overt disease characterized by vesicular lesions. HSV-1 then penetrates to the nervous system and establishes latency in sensory neurons. Throughout the lifetime of the host, HSV-1 may reactivate from its latent state and reinitiate a lytic infection cycle. HSV-1 has developed various mechanisms to escape its host innate immune responses and increased its capacity to replicate and to persist. ICP34.5, ICP0, ICP27, Us11 and Vhs (UL41) are the proteins involved in viral interference.
Class
Human Diseases; Infectious disease: viral
Pathway map
hai05168  Herpes simplex virus 1 infection
hai05168

Organism
Hipposideros armiger (great roundleaf bat) [GN:hai]
Gene
109373061  LTA; lymphotoxin-alpha [KO:K05468]
109391208  TNFRSF14; tumor necrosis factor receptor superfamily member 14 [KO:K05152]
109381672  TRAF2; TNF receptor-associated factor 2 [KO:K03173] [EC:2.3.2.27]
109379157  TRAF5; TNF receptor-associated factor 5 [KO:K09849]
109386279  IKBKB; inhibitor of nuclear factor kappa-B kinase subunit beta isoform X1 [KO:K07209] [EC:2.7.11.10]
109379632  CHUK; inhibitor of nuclear factor kappa-B kinase subunit alpha isoform X1 [KO:K04467] [EC:2.7.11.10]
109377344  IKBKG; NF-kappa-B essential modulator isoform X1 [KO:K07210]
109383860  NFKBIA; NF-kappa-B inhibitor alpha [KO:K04734]
109372541  NFKB1; nuclear factor NF-kappa-B p105 subunit isoform X1 [KO:K02580]
109384322  RELA; transcription factor p65 isoform X1 [KO:K04735]
109375115  baculoviral IAP repeat-containing protein 2-like [KO:K16060]
109375125  BIRC3; baculoviral IAP repeat-containing protein 3 isoform X1 [KO:K16060]
109376360  LOW QUALITY PROTEIN: putative inhibitor of apoptosis [KO:K16060]
109393908  NECTIN1; nectin-1 isoform X1 [KO:K06081]
109372813  NECTIN2; nectin-2 isoform X1 [KO:K06531]
109374910  paired immunoglobulin-like type 2 receptor alpha [KO:K15411]
109374934  PILRA; paired immunoglobulin-like type 2 receptor alpha isoform X1 [KO:K15411]
109382264  PTPN11; LOW QUALITY PROTEIN: tyrosine-protein phosphatase non-receptor type 11 [KO:K07293] [EC:3.1.3.48]
109391216  tyrosine-protein phosphatase non-receptor type 11-like isoform X1 [KO:K07293] [EC:3.1.3.48]
109391860  ITGA5; integrin alpha-5 [KO:K06484]
109380323  ITGB3; integrin beta-3 [KO:K06493]
109377191  SRC; proto-oncogene tyrosine-protein kinase Src isoform X1 [KO:K05704] [EC:2.7.10.2]
109375897  SYK; tyrosine-protein kinase SYK isoform X1 [KO:K05855] [EC:2.7.10.2]
109381408  CARD9; caspase recruitment domain-containing protein 9 [KO:K12794]
109391076  IRF3; interferon regulatory factor 3 [KO:K05411]
109396418  IFNB1; interferon beta [KO:K05415]
109394672  TP53; cellular tumor antigen p53 isoform X1 [KO:K04451]
109385735  C5; complement C5 [KO:K03994]
109376552  CFP; properdin [KO:K15412]
109382017  TLR2; toll-like receptor 2 [KO:K10159]
109375839  toll-like receptor 9 isoform X1 [KO:K10161]
109393491  MYD88; myeloid differentiation primary response protein MyD88 [KO:K04729]
109375630  IRF7; interferon regulatory factor 7 isoform X1 [KO:K09447]
109395856  TLR3; toll-like receptor 3 [KO:K05401]
109388568  TICAM1; TIR domain-containing adapter molecule 1 [KO:K05842]
109388403  IRAK4; interleukin-1 receptor-associated kinase 4 isoform X1 [KO:K04733] [EC:2.7.11.1]
109394352  IRAK1; interleukin-1 receptor-associated kinase 1 [KO:K04730] [EC:2.7.11.1]
109381153  TRAF6; TNF receptor-associated factor 6 isoform X1 [KO:K03175] [EC:2.3.2.27]
109389465  MAP3K7; mitogen-activated protein kinase kinase kinase 7 isoform X1 [KO:K04427] [EC:2.7.11.25]
109392251  TAB1; TGF-beta-activated kinase 1 and MAP3K7-binding protein 1 isoform X1 [KO:K04403]
109380888  TAB2; TGF-beta-activated kinase 1 and MAP3K7-binding protein 2 [KO:K04404]
109393524  IL1B; interleukin-1 beta isoform X1 [KO:K04519]
109373168  CCL5; C-C motif chemokine 5 [KO:K12499]
109387871  IL6; interleukin-6 [KO:K05405]
109373073  TNF; tumor necrosis factor isoform X1 [KO:K03156]
109373148  IL12A; LOW QUALITY PROTEIN: interleukin-12 subunit alpha [KO:K05406]
109388897  IL12B; interleukin-12 subunit beta [KO:K05425]
109371521  DDX58; probable ATP-dependent RNA helicase DDX58 [KO:K12646] [EC:5.6.2.6]
109379834  IFIH1; interferon-induced helicase C domain-containing protein 1 [KO:K12647] [EC:5.6.2.6]
109383826  MAVS; mitochondrial antiviral-signaling protein [KO:K12648]
109381072  TRAF3; TNF receptor-associated factor 3 isoform X1 [KO:K03174]
109386512  IKBKE; inhibitor of nuclear factor kappa-B kinase subunit epsilon isoform X1 [KO:K07211] [EC:2.7.11.10]
109381695  TBK1; LOW QUALITY PROTEIN: serine/threonine-protein kinase TBK1 [KO:K05410] [EC:2.7.11.10]
109374670  interferon alpha-4-like [KO:K05414]
109387546  MB21D1; cyclic GMP-AMP synthase [KO:K17834] [EC:2.7.7.86]
109393185  TMEM173; stimulator of interferon genes protein [KO:K12654]
109385685  PPP1CB; serine/threonine-protein phosphatase PP1-beta catalytic subunit isoform X1 [KO:K06269] [EC:3.1.3.16]
109384139  PPP1CA; serine/threonine-protein phosphatase PP1-alpha catalytic subunit [KO:K06269] [EC:3.1.3.16]
109386108  PPP1CC; serine/threonine-protein phosphatase PP1-gamma catalytic subunit isoform X1 [KO:K06269] [EC:3.1.3.16]
109380156  EIF2AK1; eukaryotic translation initiation factor 2-alpha kinase 1 isoform X1 [KO:K16194] [EC:2.7.11.1]
109385455  EIF2AK2; interferon-induced, double-stranded RNA-activated protein kinase [KO:K16195] [EC:2.7.11.1]
109394047  EIF2AK3; eukaryotic translation initiation factor 2-alpha kinase 3 [KO:K08860] [EC:2.7.11.1]
109383974  EIF2AK4; eIF-2-alpha kinase GCN2 [KO:K16196] [EC:2.7.11.1]
109382061  EIF2S1; eukaryotic translation initiation factor 2 subunit 1 [KO:K03237]
109386099  EIF2B1; translation initiation factor eIF-2B subunit alpha [KO:K03239]
109381520  EIF2B2; translation initiation factor eIF-2B subunit beta [KO:K03754]
109379022  EIF2B4; translation initiation factor eIF-2B subunit delta isoform X1 [KO:K03680]
109371260  EIF2B5; translation initiation factor eIF-2B subunit epsilon [KO:K03240]
109382229  LOW QUALITY PROTEIN: 2'-5'-oligoadenylate synthase 3-like [KO:K14216] [EC:2.7.7.84]
109382257  2'-5'-oligoadenylate synthase 1-like [KO:K14216] [EC:2.7.7.84]
109379163  RNASEL; 2-5A-dependent ribonuclease [KO:K01165]
109394336  HCFC1; host cell factor 1 isoform X1 [KO:K14966]
109387784  HCFC2; host cell factor 2 [KO:K27390]
109385043  POU2F1; POU domain, class 2, transcription factor 1 [KO:K09364]
109374470  POU2F2; POU domain, class 2, transcription factor 2 isoform X1 [KO:K09364]
109393892  POU2F3; POU domain, class 2, transcription factor 3 isoform X1 [KO:K09364]
109373231  IFNAR1; interferon alpha/beta receptor 1 [KO:K05130]
109373246  IFNAR2; interferon alpha/beta receptor 2 isoform X1 [KO:K05131]
109383617  SOCS3; suppressor of cytokine signaling 3 [KO:K04696]
109384938  JAK1; tyrosine-protein kinase JAK1 [KO:K11217] [EC:2.7.10.2]
109391605  TYK2; non-receptor tyrosine-protein kinase TYK2 isoform X1 [KO:K11219] [EC:2.7.10.2]
109393276  STAT1; signal transducer and activator of transcription 1-alpha/beta [KO:K11220]
109396910  STAT2; signal transducer and activator of transcription 2 isoform X1 [KO:K11221]
109393688  IRF9; interferon regulatory factor 9 [KO:K04693]
109386405  ZNF157; LOW QUALITY PROTEIN: zinc finger protein 157 [KO:K09228]
109388976  ZNF23; zinc finger protein 23 isoform X1 [KO:K09228]
109379290  LOW QUALITY PROTEIN: zinc finger protein 420-like [KO:K09228]
109379715  ZNF79; zinc finger protein 79 isoform X1 [KO:K09228]
109380201  ZNF12; zinc finger protein 12 [KO:K09228]
109380221  RBAK; RB-associated KRAB zinc finger protein isoform X1 [KO:K09228]
109380231  ZNF316; zinc finger protein 316 [KO:K09228]
109380147  ZNF853; zinc finger protein 853 [KO:K09228]
109389348  ZFP90; zinc finger protein 90 homolog isoform X1 [KO:K09228]
109382190  zinc finger protein 624 isoform X1 [KO:K09228]
109385923  ZNF41; zinc finger protein 41 [KO:K09228]
109386360  ZNF674; zinc finger protein 674 isoform X1 [KO:K09228]
109382192  ZNF286A; zinc finger protein 286A isoform X1 [KO:K09228]
109393476  ZNF619; LOW QUALITY PROTEIN: zinc finger protein 619 [KO:K09228]
109393486  ZNF620; zinc finger protein 620 isoform X1 [KO:K09228]
109393487  zinc finger protein 621-like isoform X1 [KO:K09228]
109375685  LOW QUALITY PROTEIN: zinc finger protein 256-like [KO:K09228]
109375688  LOW QUALITY PROTEIN: zinc finger protein 883-like [KO:K09228]
109375689  LOW QUALITY PROTEIN: zinc finger protein 135-like [KO:K09228]
109375691  zinc finger protein 256-like isoform X1 [KO:K09228]
109375693  ZNF606; zinc finger protein 606 isoform X1 [KO:K09228]
109375695  LOW QUALITY PROTEIN: zinc finger protein 883-like [KO:K09228]
109375697  zinc finger protein 551-like [KO:K09228]
109375698  zinc finger protein 154-like [KO:K09228]
109374336  zinc finger protein 470 isoform X1 [KO:K09228]
109374338  LOW QUALITY PROTEIN: zinc finger protein 471-like [KO:K09228]
109374339  ZNF582; zinc finger protein 582 isoform X1 [KO:K09228]
109374346  ZNF583; LOW QUALITY PROTEIN: zinc finger protein 583 [KO:K09228]
109374347  ZNF667; LOW QUALITY PROTEIN: zinc finger protein 667 [KO:K09228]
109375704  ZNF8; zinc finger protein 8 isoform X1 [KO:K09228]
109375714  ZNF184; zinc finger protein 184 [KO:K09228]
109377155  ZNF3; LOW QUALITY PROTEIN: zinc finger protein 3 [KO:K09228]
109378732  LOW QUALITY PROTEIN: zinc finger protein 614-like [KO:K09228]
109375892  ZNF436; zinc finger protein 436 isoform X1 [KO:K09228]
109377406  LOW QUALITY PROTEIN: uncharacterized protein LOC109377406 [KO:K09228]
109377409  zinc finger protein 577-like [KO:K09228]
109377411  LOW QUALITY PROTEIN: zinc finger protein 605-like [KO:K09228]
109390834  ZNF623; zinc finger protein 623 [KO:K09228]
109377078  ZNF132; LOW QUALITY PROTEIN: zinc finger protein 132 [KO:K09228]
109377080  zinc finger protein 132-like isoform X1 [KO:K09228]
109377082  zinc finger protein 324A-like isoform X1 [KO:K09228]
109377087  ZNF584; zinc finger protein 584 isoform X1 [KO:K09228]
109384345  ZNF343; LOW QUALITY PROTEIN: zinc finger protein 343 [KO:K09228]
109389781  ZNF354A; zinc finger protein 354A [KO:K09228]
109372828  ZNF229; zinc finger protein 229 isoform X1 [KO:K09228]
109374165  ZNF768; zinc finger protein 768 isoform X1 [KO:K09228]
109374202  zinc finger protein 764-like isoform X1 [KO:K09228]
109374203  ZNF688; zinc finger protein 688 isoform X1 [KO:K09228]
109374211  ZNF689; zinc finger protein 689 [KO:K09228]
109378617  ZNF382; zinc finger protein 382 [KO:K09228]
109389658  ZNF746; zinc finger protein 746 isoform X1 [KO:K09228]
109390990  ZNF114; zinc finger protein 114 isoform X1 [KO:K09228]
109389678  ZNF777; zinc finger protein 777 [KO:K09228]
109391050  ZNF473; zinc finger protein 473 [KO:K09228]
109391051  LOW QUALITY PROTEIN: zinc finger protein 883 [KO:K09228]
109395043  ZNF189; zinc finger protein 189 isoform X1 [KO:K09228]
109388630  ZNF77; zinc finger protein 77 isoform X1 [KO:K09228]
109372004  ZNF792; zinc finger protein 792 [KO:K09228]
109372011  zinc finger protein 850-like [KO:K09228]
109372019  ZNF30; zinc finger protein 30 isoform X1 [KO:K09228]
109372024  ZNF567; zinc finger protein 567 [KO:K09228]
109372025  ZNF181; zinc finger protein 181 isoform X1 [KO:K09228]
109372029  ZNF599; zinc finger protein 599 [KO:K09228]
109372031  ZNF565; zinc finger protein 565 isoform X1 [KO:K09228]
109372035  zinc finger protein 599-like [KO:K09228]
109392752  ZNF354C; zinc finger protein 354C isoform X1 [KO:K09228]
109392753  ZNF879; zinc finger protein 879 [KO:K09228]
109392754  zinc finger protein 454 isoform X1 [KO:K09228]
109395532  ZNF33B; zinc finger protein 33B [KO:K09228]
109395533  ZNF248; zinc finger protein 248 [KO:K09228]
109395534  ZNF25; zinc finger protein 25 isoform X1 [KO:K09228]
109372368  LOW QUALITY PROTEIN: zinc finger protein 420-like [KO:K09228]
109375056  ZNF7; zinc finger protein 7 isoform X1 [KO:K09228]
109375061  ZNF34; zinc finger protein 34 isoform X1 [KO:K09228]
109375065  ZNF251; zinc finger protein 251 isoform X1 [KO:K09228]
109376475  zinc finger protein OZF-like [KO:K09228]
109376488  ZNF558; zinc finger protein 558 [KO:K09228]
109376489  ZNF317; zinc finger protein 317 [KO:K09228]
109376145  ZNF268; zinc finger protein 268 isoform X1 [KO:K09228]
109376146  zinc finger protein 84 isoform X1 [KO:K09228]
109376147  ZNF605; zinc finger protein 605 [KO:K09228]
109376148  ZNF10; zinc finger protein 10 isoform X1 [KO:K09228]
109376150  ZNF891; zinc finger protein 891 [KO:K09228]
109376151  ZNF140; zinc finger protein 140 isoform X1 [KO:K09228]
109376558  ZNF81; zinc finger protein 81 [KO:K09228]
109376559  ZNF182; zinc finger protein 182 isoform X1 [KO:K09228]
109376573  zinc finger protein 585A isoform X1 [KO:K09228]
109376574  LOW QUALITY PROTEIN: zinc finger protein 569-like [KO:K09228]
109376575  zinc finger protein 420 isoform X1 [KO:K09228]
109376578  ZNF570; zinc finger protein 570 isoform X1 [KO:K09228]
109376579  zinc finger protein 383 [KO:K09228]
109376580  ZNF829; zinc finger protein 829 [KO:K09228]
109378060  ZNF568; zinc finger protein 568 isoform X1 [KO:K09228]
109378061  zinc finger protein 14 homolog [KO:K09228]
109376576  ZNF527; zinc finger protein 527 isoform X1 [KO:K09228]
109376577  LOW QUALITY PROTEIN: zinc finger protein 345-like [KO:K09228]
109376676  LOW QUALITY PROTEIN: zinc finger protein 211-like [KO:K09228]
109376685  ZNF510; zinc finger protein 510 [KO:K09228]
109376693  zinc finger protein 782-like [KO:K09228]
109376715  ZNF133; zinc finger protein 133 [KO:K09228]
109378158  ZNF699; zinc finger protein 699 isoform X1 [KO:K09228]
109378171  ZNF175; zinc finger protein 175 [KO:K09228]
109378197  ZNF398; zinc finger protein 398 [KO:K09228]
109378198  ZNF783; protein ZNF783 [KO:K09228]
109378199  ZNF212; zinc finger protein 212 isoform X1 [KO:K09228]
109392011  ZNF2; zinc finger protein 2 isoform X1 [KO:K09228]
109372789  ZNF112; zinc finger protein 112 isoform X1 [KO:K09228]
109372790  ZNF227; zinc finger protein 227 isoform X1 [KO:K09228]
109372792  zinc finger protein 226-like isoform X1 [KO:K09228]
109372793  ZNF235; zinc finger protein 235 [KO:K09228]
109372794  ZNF45; zinc finger protein 45 isoform X1 [KO:K09228]
109372796  ZNF404; zinc finger protein 404 [KO:K09228]
109378410  LOW QUALITY PROTEIN: zinc finger protein 709-like [KO:K09228]
109378476  ZNF311; zinc finger protein 311 [KO:K09228]
109376864  ZNF300; zinc finger protein 300 isoform X1 [KO:K09228]
109376886  ZNF484; LOW QUALITY PROTEIN: zinc finger protein 484 [KO:K09228]
109377894  zinc finger protein 82 homolog isoform X1 [KO:K09228]
109377901  ZFP57; zinc finger protein 57 homolog isoform X1 [KO:K09228]
109394350  ZNF275; zinc finger protein 275 [KO:K09228]
109394387  zinc finger protein 658-like isoform X1 [KO:K09228]
109372471  ZNF331; LOW QUALITY PROTEIN: zinc finger protein 331 [KO:K09228]
109372476  zinc finger protein 420-like [KO:K09228]
109372477  LOW QUALITY PROTEIN: zinc finger protein 708-like [KO:K09228]
109372526  ZNF641; zinc finger protein 641 [KO:K09228]
109376653  LOW QUALITY PROTEIN: zinc finger protein 551-like [KO:K09228]
109376660  zinc finger protein 548-like [KO:K09228]
109376661  ZNF772; zinc finger protein 772 isoform X1 [KO:K09228]
109376662  ZNF550; zinc finger protein 550 [KO:K09228]
109376663  zinc finger protein 773-like [KO:K09228]
109376664  zinc finger protein 416-like [KO:K09228]
109376667  ZNF304; LOW QUALITY PROTEIN: zinc finger protein 304 [KO:K09228]
109376671  zinc finger protein 543-like [KO:K09228]
109390643  zinc finger protein 555-like isoform X1 [KO:K09228]
109371896  ZNF782; LOW QUALITY PROTEIN: zinc finger protein 782 [KO:K09228]
109377419  ZNF333; zinc finger protein 333 [KO:K09228]
109383392  ZNF684; zinc finger protein 684 isoform X1 [KO:K09228]
109374863  zinc finger protein 546-like isoform X1 [KO:K09228]
109376267  ZNF713; zinc finger protein 713 isoform X1 [KO:K09228]
109376328  ZNF214; zinc finger protein 214 [KO:K09228]
109377752  zinc finger protein 211-like isoform X1 [KO:K09228]
109377481  zinc finger protein 525-like [KO:K09228]
109377485  zinc finger protein 350-like [KO:K09228]
109377486  zinc finger protein 350-like [KO:K09228]
109387655  zinc finger protein 705A-like [KO:K09228]
109391618  zinc finger protein 791-like isoform X1 [KO:K09228]
109391619  zinc finger protein 709-like [KO:K09228]
109391620  zinc finger protein 709-like [KO:K09228]
109391665  zinc finger protein 709-like isoform X1 [KO:K09228]
109391666  LOW QUALITY PROTEIN: zinc finger protein 791-like [KO:K09228]
109391672  LOW QUALITY PROTEIN: zinc finger protein 709-like [KO:K09228]
109391673  zinc finger protein 14-like isoform X1 [KO:K09228]
109376675  zinc finger protein 805-like [KO:K09228]
109376228  ZNF74; zinc finger protein 74 [KO:K09228]
109377605  zinc finger protein 658-like isoform X1 [KO:K09228]
109377606  LOW QUALITY PROTEIN: zinc finger protein 658-like [KO:K09228]
109377653  zinc finger protein 665-like [KO:K09228]
109377657  zinc finger protein OZF-like [KO:K09228]
109384816  ZFP1; zinc finger protein 1 homolog isoform X1 [KO:K09228]
109395447  ZNF425; LOW QUALITY PROTEIN: zinc finger protein 425 [KO:K09228]
109395454  ZNF786; zinc finger protein 786 [KO:K09228]
109396717  ZNF596; zinc finger protein 596 isoform X1 [KO:K09228]
109391576  zinc finger protein 709-like [KO:K09228]
109391582  zinc finger protein 709-like [KO:K09228]
109391587  LOW QUALITY PROTEIN: zinc finger protein 14-like [KO:K09228]
109394222  zinc finger protein 791-like [KO:K09228]
109394233  LOW QUALITY PROTEIN: zinc finger protein 709-like [KO:K09228]
109390570  LOW QUALITY PROTEIN: zinc finger protein 709-like [KO:K09228]
109376756  LOW QUALITY PROTEIN: zinc finger and SCAN domain-containing protein 32-like [KO:K09228]
109376767  ZNF200; zinc finger protein 200 isoform X1 [KO:K09228]
109376778  ZNF205; zinc finger protein 205 isoform X1 [KO:K09228]
109378387  zinc finger protein 658-like isoform X1 [KO:K09228]
109376951  ZNF502; LOW QUALITY PROTEIN: zinc finger protein 502 [KO:K09228]
109379064  ZNF789; zinc finger protein 789 isoform X1 [KO:K09228]
109378795  LOW QUALITY PROTEIN: histone-lysine N-methyltransferase PRDM9-like [KO:K09228]
109375928  zinc finger protein 430-like isoform X1 [KO:K09228]
109377405  zinc finger protein 182-like [KO:K09228]
109383347  uncharacterized protein LOC109383347 [KO:K09228]
109376227  LOW QUALITY PROTEIN: zinc finger protein 420-like [KO:K09228]
109393004  zinc finger protein 501-like [KO:K09228]
109377989  zinc finger protein 14-like [KO:K09228]
109372472  LOW QUALITY PROTEIN: zinc finger protein 708-like [KO:K09228]
109387894  ZNF397; zinc finger protein 397 [KO:K09228]
109376673  zinc finger protein 264-like isoform X1 [KO:K09228]
109382353  BST2; bone marrow stromal antigen 2 [KO:K06731]
109381671  IFNG; interferon gamma [KO:K04687]
109385640  IFNGR1; interferon gamma receptor 1 isoform X1 [KO:K05132]
109376141  LOW QUALITY PROTEIN: interferon gamma receptor 1-like [KO:K05132]
109373230  IFNGR2; interferon gamma receptor 2 [KO:K05133]
109384506  JAK2; tyrosine-protein kinase JAK2 isoform X1 [KO:K04447] [EC:2.7.10.2]
109392423  DAXX; death domain-associated protein 6 isoform X1 [KO:K02308]
109374289  SP100; nuclear autoantigen Sp-100 isoform X1 [KO:K15413]
109396273  PML; protein PML isoform X1 [KO:K10054] [EC:2.3.2.-]
109378146  TAP1; antigen peptide transporter 1 isoform X1 [KO:K05653] [EC:7.4.2.14]
109378144  TAP2; antigen peptide transporter 2 [KO:K05654] [EC:7.4.2.14]
109392427  TAPBP; tapasin [KO:K08058]
109384022  PDIA3; protein disulfide-isomerase A3 [KO:K08056] [EC:5.3.4.1]
109394224  CALR; calreticulin [KO:K08057]
109376402  LOW QUALITY PROTEIN: calreticulin-like [KO:K08057]
109373056  HLA class I histocompatibility antigen, B-73 alpha chain-like [KO:K06751]
109378624  HLA class I histocompatibility antigen, B-15 alpha chain-like isoform X1 [KO:K06751]
109378610  HLA class I histocompatibility antigen, B-46 alpha chain-like [KO:K06751]
109373110  HLA class I histocompatibility antigen, B-67 alpha chain-like [KO:K06751]
109376695  class I histocompatibility antigen, Gogo-B*0102 alpha chain-like [KO:K06751]
109376696  patr class I histocompatibility antigen, A-2 alpha chain-like [KO:K06751]
109376701  HLA class I histocompatibility antigen, B-37 alpha chain-like isoform X1 [KO:K06751]
109378398  class I histocompatibility antigen, Gogo-B*0101 alpha chain-like [KO:K06751]
109377928  patr class I histocompatibility antigen, A-126 alpha chain-like [KO:K06751]
109377929  popy Class I histocompatibility antigen, A-1 alpha chain-like [KO:K06751]
109377720  HLA class I histocompatibility antigen, A-30 alpha chain-like [KO:K06751]
109377721  patr class I histocompatibility antigen, A-126 alpha chain-like [KO:K06751]
109377607  patr class I histocompatibility antigen, A-126 alpha chain-like [KO:K06751]
109377608  patr class I histocompatibility antigen, A-126 alpha chain-like isoform X1 [KO:K06751]
109377610  HLA class I histocompatibility antigen, A-30 alpha chain-like isoform X1 [KO:K06751]
109378301  class I histocompatibility antigen, Gogo-A*0201 alpha chain-like [KO:K06751]
109384088  B2M; beta-2-microglobulin [KO:K08055]
109373047  HLA class II histocompatibility antigen, DR alpha chain [KO:K06752]
109392411  HLA class II histocompatibility antigen, DP beta 1 chain [KO:K06752]
109392415  HLA class II histocompatibility antigen, DP alpha 1 chain [KO:K06752]
109378577  HLA class II histocompatibility antigen, DM beta chain [KO:K06752]
109373106  H-2 class II histocompatibility antigen, E-S beta chain [KO:K06752]
109373108  HLA class II histocompatibility antigen, DQ alpha 2 chain-like [KO:K06752]
109373109  HLA class II histocompatibility antigen, DQ beta 2 chain-like isoform X1 [KO:K06752]
109377860  HLA class II histocompatibility antigen, DQ beta 2 chain-like isoform X1 [KO:K06752]
109377861  HLA class II histocompatibility antigen, DQ beta 1 chain-like [KO:K06752]
109377862  H-2 class II histocompatibility antigen, A-F alpha chain-like [KO:K06752]
109377863  HLA class II histocompatibility antigen, DQ alpha 2 chain-like [KO:K06752]
109376897  SLA class II histocompatibility antigen, DQ haplotype D alpha chain-like [KO:K06752]
109376898  HLA class II histocompatibility antigen, DQ alpha 2 chain-like [KO:K06752]
109378434  HLA class II histocompatibility antigen, DM alpha chain [KO:K06752]
109378436  HLA class II histocompatibility antigen, DO alpha chain [KO:K06752]
109376891  SLA class II histocompatibility antigen, DQ haplotype C beta chain-like isoform X1 [KO:K06752]
109376893  rano class II histocompatibility antigen, A beta chain-like isoform X1 [KO:K06752]
109377864  SLA class II histocompatibility antigen, DQ haplotype D alpha chain-like [KO:K06752]
109378145  HLA class II histocompatibility antigen, DO beta chain-like isoform X1 [KO:K06752]
109376871  CD74; HLA class II histocompatibility antigen gamma chain isoform X1 [KO:K06505]
109381238  PIK3CD; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform [KO:K00922] [EC:2.7.1.153]
109394108  PIK3CB; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform [KO:K00922] [EC:2.7.1.153]
109372681  PIK3CA; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform isoform X1 [KO:K00922] [EC:2.7.1.153]
109382484  PIK3R2; phosphatidylinositol 3-kinase regulatory subunit beta [KO:K02649]
109395865  PIK3R1; phosphatidylinositol 3-kinase regulatory subunit alpha isoform X1 [KO:K02649]
109373811  PIK3R3; phosphatidylinositol 3-kinase regulatory subunit gamma isoform X1 [KO:K02649]
109381083  AKT1; RAC-alpha serine/threonine-protein kinase [KO:K04456] [EC:2.7.11.1]
109385878  RAC-beta serine/threonine-protein kinase-like isoform X1 [KO:K04456] [EC:2.7.11.1]
109374859  AKT2; RAC-beta serine/threonine-protein kinase [KO:K04456] [EC:2.7.11.1]
109385353  AKT3; RAC-gamma serine/threonine-protein kinase isoform X1 [KO:K04456] [EC:2.7.11.1]
109380979  TSC1; hamartin isoform X1 [KO:K07206]
109385868  TSC2; tuberin isoform X1 [KO:K07207]
109389671  RHEB; GTP-binding protein Rheb [KO:K07208]
109381262  MTOR; serine/threonine-protein kinase mTOR [KO:K07203] [EC:2.7.11.1]
109393572  EIF4EBP1; eukaryotic translation initiation factor 4E-binding protein 1 [KO:K07205]
109395986  SRPK1; LOW QUALITY PROTEIN: SRSF protein kinase 1 [KO:K15409] [EC:2.7.11.1]
109379802  SRSF1; serine/arginine-rich splicing factor 1 [KO:K12890]
109383654  SRSF2; serine/arginine-rich splicing factor 2 [KO:K12891]
109392089  SRSF4; serine/arginine-rich splicing factor 4 [KO:K12893]
109379958  SRSF6; serine/arginine-rich splicing factor 6 [KO:K12893]
109382108  SRSF5; serine/arginine-rich splicing factor 5 [KO:K12893]
109385476  SRSF7; serine/arginine-rich splicing factor 7 isoform X1 [KO:K12896]
109386188  SRSF9; serine/arginine-rich splicing factor 9 [KO:K21123]
109389566  NXF5; LOW QUALITY PROTEIN: nuclear RNA export factor 5 [KO:K14284]
109384235  NXF1; nuclear RNA export factor 1 [KO:K14284]
109376052  NXF3; LOW QUALITY PROTEIN: nuclear RNA export factor 3 [KO:K14284]
109377472  LOW QUALITY PROTEIN: nuclear RNA export factor 2-like [KO:K14284]
109393013  ALYREF; THO complex subunit 4 [KO:K12881]
109385146  FASLG; tumor necrosis factor ligand superfamily member 6 [KO:K04389]
109377126  FAS; tumor necrosis factor receptor superfamily member 6 [KO:K04390]
109373644  TNFRSF1A; tumor necrosis factor receptor superfamily member 1A [KO:K03158]
109390108  TRADD; tumor necrosis factor receptor type 1-associated DEATH domain protein isoform X1 [KO:K03171]
109389315  FADD; FAS-associated death domain protein [KO:K02373]
109379228  CASP8; caspase-8 [KO:K04398] [EC:3.4.22.61]
109373303  BID; BH3-interacting domain death agonist [KO:K04726]
109391068  BAX; apoptosis regulator BAX [KO:K02159]
109392454  BAK1; bcl-2 homologous antagonist/killer isoform X1 [KO:K14021]
109384256  BAD; bcl2-associated agonist of cell death [KO:K02158]
109390784  BCL2; apoptosis regulator Bcl-2 isoform X1 [KO:K02161]
109384429  BCL2L1; bcl-2-like protein 1 isoform X1 [KO:K04570]
109373362  bcl-2-like protein 1 isoform X1 [KO:K04570]
109393551  cytochrome c [KO:K08738]
109381354  cytochrome c [KO:K08738]
109382336  APAF1; apoptotic protease-activating factor 1 isoform X1 [KO:K02084]
109381302  CASP9; caspase-9 isoform X1 [KO:K04399] [EC:3.4.22.62]
109395706  CASP3; caspase-3 isoform X1 [KO:K02187] [EC:3.4.22.56]
Compound
C05981  Phosphatidylinositol-3,4,5-trisphosphate
C20640  Cyclic GMP-AMP
C20935  2-5A
Reference
PMID:12787566
  Authors
Granger SW, Rickert S
  Title
LIGHT-HVEM signaling and the regulation of T cell-mediated immunity.
  Journal
Cytokine Growth Factor Rev 14:289-96 (2003)
DOI:10.1016/S1359-6101(03)00031-5
Reference
PMID:19495760
  Authors
Steinberg MW, Shui JW, Ware CF, Kronenberg M
  Title
Regulating the mucosal immune system: the contrasting roles of LIGHT, HVEM, and their various partners.
  Journal
Semin Immunopathol 31:207-21 (2009)
DOI:10.1007/s00281-009-0157-4
Reference
PMID:20221426
  Authors
MacLeod IJ, Minson T
  Title
Binding of herpes simplex virus type-1 virions leads to the induction of intracellular signalling in the absence of virus entry.
  Journal
PLoS One 5:e9560 (2010)
DOI:10.1371/journal.pone.0009560
Reference
PMID:23150579
  Authors
Gianni T, Leoni V, Chesnokova LS, Hutt-Fletcher LM, Campadelli-Fiume G
  Title
alphavbeta3-integrin is a major sensor and activator of innate immunity to herpes simplex virus-1.
  Journal
Proc Natl Acad Sci U S A 109:19792-7 (2012)
DOI:10.1073/pnas.1212597109
Reference
PMID:25375272
  Authors
Gianni T, Campadelli-Fiume G
  Title
The epithelial alphavbeta3-integrin boosts the MYD88-dependent TLR2 signaling in response to viral and bacterial components.
  Journal
PLoS Pathog 10:e1004477 (2014)
DOI:10.1371/journal.ppat.1004477
Reference
PMID:15056211
  Authors
Spear PG
  Title
Herpes simplex virus: receptors and ligands for cell entry.
  Journal
Cell Microbiol 6:401-10 (2004)
DOI:10.1111/j.1462-5822.2004.00389.x
Reference
PMID:12855695
  Authors
Boutell C, Everett RD
  Title
The herpes simplex virus type 1 (HSV-1) regulatory protein ICP0 interacts with and Ubiquitinates p53.
  Journal
J Biol Chem 278:36596-602 (2003)
DOI:10.1074/jbc.M300776200
Reference
PMID:24262390
  Authors
Ma Y, He B
  Title
Recognition of herpes simplex viruses: toll-like receptors and beyond.
  Journal
J Mol Biol 426:1133-47 (2014)
DOI:10.1016/j.jmb.2013.11.012
Reference
PMID:26952111
  Authors
Su C, Zhan G, Zheng C
  Title
Evasion of host antiviral innate immunity by HSV-1, an update.
  Journal
Virol J 13:38 (2016)
DOI:10.1186/s12985-016-0495-5
Reference
PMID:21994567
  Authors
Melchjorsen J, Matikainen S, Paludan SR
  Title
Activation and evasion of innate antiviral immunity by herpes simplex virus.
  Journal
Viruses 1:737-59 (2009)
DOI:10.3390/v1030737
Reference
PMID:15276609
  Authors
Morrison LA
  Title
The Toll of herpes simplex virus infection.
  Journal
Trends Microbiol 12:353-6 (2004)
DOI:10.1016/j.tim.2004.06.001
Reference
PMID:29298887
  Authors
Zheng C
  Title
Evasion of Cytosolic DNA-Stimulated Innate Immune Responses by Herpes Simplex Virus 1.
  Journal
J Virol 92:e00099-17 (2018)
DOI:10.1128/JVI.00099-17
Reference
PMID:19344302
  Authors
Grandi P, Peruzzi P, Reinhart B, Cohen JB, Chiocca EA, Glorioso JC
  Title
Design and application of oncolytic HSV vectors for glioblastoma therapy.
  Journal
Expert Rev Neurother 9:505-17 (2009)
DOI:10.1586/ern.09.9
Reference
PMID:23115300
  Authors
Lussignol M, Queval C, Bernet-Camard MF, Cotte-Laffitte J, Beau I, Codogno P, Esclatine A
  Title
The herpes simplex virus 1 Us11 protein inhibits autophagy through its interaction with the protein kinase PKR.
  Journal
J Virol 87:859-71 (2013)
DOI:10.1128/JVI.01158-12
Reference
PMID:17229694
  Authors
Sanchez R, Mohr I
  Title
Inhibition of cellular 2'-5' oligoadenylate synthetase by the herpes simplex virus type 1 Us11 protein.
  Journal
J Virol 81:3455-64 (2007)
DOI:10.1128/JVI.02520-06
Reference
PMID:12826401
  Authors
Wysocka J, Herr W
  Title
The herpes simplex virus VP16-induced complex: the makings of a regulatory switch.
  Journal
Trends Biochem Sci 28:294-304 (2003)
DOI:10.1016/S0968-0004(03)00088-4
Reference
PMID:27367734
  Authors
Fleming SB
  Title
Viral Inhibition of the IFN-Induced JAK/STAT Signalling Pathway: Development of Live Attenuated Vaccines by Mutation of Viral-Encoded IFN-Antagonists.
  Journal
Vaccines (Basel) 4:E23 (2016)
DOI:10.3390/vaccines4030023
Reference
PMID:15163721
  Authors
Yokota S, Yokosawa N, Okabayashi T, Suzutani T, Miura S, Jimbow K, Fujii N
  Title
Induction of suppressor of cytokine signaling-3 by herpes simplex virus type 1 contributes to inhibition of the interferon signaling pathway.
  Journal
J Virol 78:6282-6 (2004)
DOI:10.1128/JVI.78.12.6282-6286.2004
Reference
PMID:23864622
  Authors
Gu H, Zheng Y, Roizman B
  Title
Interaction of herpes simplex virus ICP0 with ND10 bodies: a sequential process of adhesion, fusion, and retention.
  Journal
J Virol 87:10244-54 (2013)
DOI:10.1128/JVI.01487-13
Reference
PMID:21994592
  Authors
Tavalai N, Stamminger T
  Title
Interplay between Herpesvirus Infection and Host Defense by PML Nuclear Bodies.
  Journal
Viruses 1:1240-64 (2009)
DOI:10.3390/v1031240
Reference
PMID:21146386
  Authors
Horst D, Verweij MC, Davison AJ, Ressing ME, Wiertz EJ
  Title
Viral evasion of T cell immunity: ancient mechanisms offering new applications.
  Journal
Curr Opin Immunol 23:96-103 (2011)
DOI:10.1016/j.coi.2010.11.005
Reference
PMID:12960333
  Authors
Neumann J, Eis-Hubinger AM, Koch N
  Title
Herpes simplex virus type 1 targets the MHC class II processing pathway for immune evasion.
  Journal
J Immunol 171:3075-83 (2003)
DOI:10.4049/jimmunol.171.6.3075
Reference
PMID:25798530
  Authors
Liu X, Cohen JI
  Title
The role of PI3K/Akt in human herpesvirus infection: From the bench to the bedside.
  Journal
Virology 479-480:568-77 (2015)
DOI:10.1016/j.virol.2015.02.040
Reference
PMID:28468873
  Authors
Vink EI, Smiley JR, Mohr I
  Title
Subversion of Host Responses to Energy Insufficiency by Us3 Supports Herpes Simplex Virus 1 Replication during Stress.
  Journal
J Virol 91:e00295-17 (2017)
DOI:10.1128/JVI.00295-17
Reference
PMID:18508584
  Authors
Sandri-Goldin RM
  Title
The many roles of the regulatory protein ICP27 during herpes simplex virus infection.
  Journal
Front Biosci 13:5241-56 (2008)
DOI:10.2741/3078
Reference
PMID:15078920
  Authors
Sandri-Goldin RM
  Title
Viral regulation of mRNA export.
  Journal
J Virol 78:4389-96 (2004)
DOI:10.1128/JVI.78.9.4389-4396.2004
Reference
PMID:27154074
  Authors
Yu X, He S
  Title
The interplay between human herpes simplex virus infection and the apoptosis and necroptosis cell death pathways.
  Journal
Virol J 13:77 (2016)
DOI:10.1186/s12985-016-0528-0
Related
pathway
hai03040  Spliceosome
hai03050  Proteasome
hai04115  p53 signaling pathway
hai04151  PI3K-Akt signaling pathway
hai04210  Apoptosis
hai04610  Complement and coagulation cascades
hai04612  Antigen processing and presentation
hai04620  Toll-like receptor signaling pathway
hai04622  RIG-I-like receptor signaling pathway
hai04630  JAK-STAT signaling pathway
KO pathway
ko05168   
LinkDB

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