Entry
Name
Spliceosome - Hippoglossus stenolepis (Pacific halibut)
Description
After transcription, eukaryotic mRNA precursors contain protein-coding exons and noncoding introns. In the following splicing, introns are excised and exons are joined by a macromolecular complex, the spliceosome. The standard spliceosome is made up of five small nuclear ribonucleoproteins (snRNPs), U1, U2, U4, U5, and U6 snRNPs, and several spliceosome-associated proteins (SAPs). Spliceosomes are not a simple stable complex, but a dynamic family of particles that assemble on the mRNA precursor and help fold it into a conformation that allows transesterification to proceed. Various spliceosome forms (e.g. A-, B- and C-complexes) have been identified.
Class
Genetic Information Processing; Transcription
BRITE hierarchy
Pathway map
Other DBs
Organism
Hippoglossus stenolepis (Pacific halibut) [GN:
hsp ]
Gene
118098490 puf60b; poly(U)-binding-splicing factor PUF60-B isoform X1 [KO:K12838 ]
118101077 snu13b; SNU13 homolog, small nuclear ribonucleoprotein b (U4/U6.U5) [KO:K12845 ]
118102751 hnrnpc; heterogeneous nuclear ribonucleoproteins C1/C2 isoform X1 [KO:K12884 ]
118104413 snrpb; small nuclear ribonucleoprotein-associated proteins B and B' [KO:K11086 ]
118105922 taf15; TATA-binding protein-associated factor 2N isoform X1 [KO:K13098 ]
118106471 srsf1a; serine/arginine-rich splicing factor 1A isoform X1 [KO:K12890 ]
118110279 dhx38; pre-mRNA-splicing factor ATP-dependent RNA helicase PRP16 isoform X1 [KO:K12815 ] [EC:5.6.2.6 ]
118110738 hnrnpa1b; heterogeneous nuclear ribonucleoprotein A1b isoform X1 [KO:K12741 ]
118110885 snrpa1; U2 small nuclear ribonucleoprotein A' isoform X1 [KO:K11092 ]
118110976 gpkow; G-patch domain and KOW motifs-containing protein [KO:K13101 ]
118113197 u2af2a; U2 small nuclear RNA auxiliary factor 2a isoform X1 [KO:K12837 ]
118113395 srsf10a; serine/arginine-rich splicing factor 10 isoform X1 [KO:K12900 ]
118114780 hnrnpk; heterogeneous nuclear ribonucleoprotein K isoform X1 [KO:K12886 ]
118115588 snrnp27; U4/U6.U5 small nuclear ribonucleoprotein 27 kDa protein [KO:K12846 ]
118116503 snrpb2; U2 small nuclear ribonucleoprotein B'' isoform X1 [KO:K11094 ]
118117332 acin1a; apoptotic chromatin condensation inducer in the nucleus [KO:K12875 ]
118117461 puf60a; poly(U)-binding-splicing factor PUF60a isoform X1 [KO:K12838 ]
118119025 smndc1; survival of motor neuron-related-splicing factor 30 [KO:K12839 ]
118120249 prpf40a; pre-mRNA-processing factor 40 homolog A isoform X1 [KO:K12821 ]
118120918 hnrnpm; heterogeneous nuclear ribonucleoprotein M isoform X1 [KO:K12887 ]
118122299 zgc:163098; U2 snRNP-associated SURP motif-containing protein [KO:K12842 ]
118122934 eftud2; 116 kDa U5 small nuclear ribonucleoprotein component [KO:K12852 ]
118123970 srsf2b; serine/arginine-rich splicing factor 2b isoform X1 [KO:K12891 ]
118124545 snrnp40; U5 small nuclear ribonucleoprotein 40 kDa protein [KO:K12857 ]
118124693 tra2a; transformer-2 protein homolog alpha isoform X1 [KO:K12897 ]
118125519 hnrpkl; heterogeneous nuclear ribonucleoprotein K, like isoform X1 [KO:K12886 ]
118125550 snrpd3l; small nuclear ribonucleoprotein D3 polypeptide, like [KO:K11088 ]
Reference
Authors
Wahl MC, Will CL, Luhrmann R
Title
The spliceosome: design principles of a dynamic RNP machine.
Journal
Reference
Authors
Morris DP, Greenleaf AL
Title
The splicing factor, Prp40, binds the phosphorylated carboxyl-terminal domain of RNA polymerase II.
Journal
Reference
Authors
Chen YI, Moore RE, Ge HY, Young MK, Lee TD, Stevens SW
Title
Proteomic analysis of in vivo-assembled pre-mRNA splicing complexes expands the catalog of participating factors.
Journal
Reference
Authors
Ritchie DB, Schellenberg MJ, MacMillan AM
Title
Spliceosome structure: piece by piece.
Journal
Reference
Authors
Bertram K, Agafonov DE, Dybkov O, Haselbach D, Leelaram MN, Will CL, Urlaub H, Kastner B, Luhrmann R, Stark H
Title
Cryo-EM Structure of a Pre-catalytic Human Spliceosome Primed for Activation.
Journal
Reference
Authors
Zhang X, Yan C, Zhan X, Li L, Lei J, Shi Y
Title
Structure of the human activated spliceosome in three conformational states.
Journal
Reference
Authors
Haselbach D, Komarov I, Agafonov DE, Hartmuth K, Graf B, Dybkov O, Urlaub H, Kastner B, Luhrmann R, Stark H
Title
Structure and Conformational Dynamics of the Human Spliceosomal B(act) Complex.
Journal
Reference
Authors
Zhan X, Lu Y, Shi Y
Title
Molecular basis for the activation of human spliceosome.
Journal
KO pathway