KEGG   PATHWAY: lav04621
Entry
lav04621                    Pathway                                
Name
NOD-like receptor signaling pathway - Loxodonta africana (African savanna elephant)
Description
Specific families of pattern recognition receptors are responsible for detecting various pathogens and generating innate immune responses. The intracellular NOD-like receptor (NLR) family contains more than 20 members in mammals and plays a pivotal role in the recognition of intracellular ligands. NOD1 and NOD2, two prototypic NLRs, sense the cytosolic presence of the bacterial peptidoglycan fragments that escaped from endosomal compartments, driving the activation of NF-{kappa}B and MAPK, cytokine production and apoptosis. On the other hand, a different set of NLRs induces caspase-1 activation through the assembly of multiprotein complexes called inflammasomes. The activated of caspase-1 regulates maturation of the pro-inflammatory cytokines IL-1B, IL-18 and drives pyroptosis.
Class
Organismal Systems; Immune system
Pathway map
lav04621  NOD-like receptor signaling pathway
lav04621

Organism
Loxodonta africana (African savanna elephant) [GN:lav]
Gene
100664068  NOD1; nucleotide-binding oligomerization domain-containing protein 1 isoform X1 [KO:K08727]
100663221  RIPK2; receptor-interacting serine/threonine-protein kinase 2 isoform X1 [KO:K08846] [EC:2.7.11.1]
100661492  IKBKG; LOW QUALITY PROTEIN: NF-kappa-B essential modulator [KO:K07210]
100664361  CHUK; inhibitor of nuclear factor kappa-B kinase subunit alpha isoform X1 [KO:K04467] [EC:2.7.11.10]
100657363  IKBKB; inhibitor of nuclear factor kappa-B kinase subunit beta isoform X3 [KO:K07209] [EC:2.7.11.10]
100657581  NFKBIB; NF-kappa-B inhibitor beta [KO:K02581]
100675651  NFKBIA; NF-kappa-B inhibitor alpha [KO:K04734]
100662194  NFKB1; nuclear factor NF-kappa-B p105 subunit isoform X1 [KO:K02580]
100654730  RELA; transcription factor p65 isoform X2 [KO:K04735]
100674746  IL1B; interleukin-1 beta [KO:K04519]
100668369  IL18; interleukin-18 isoform X1 [KO:K05482]
100660846  IL6; interleukin-6 [KO:K05405]
100677125  TNF; tumor necrosis factor isoform X2 [KO:K03156]
100664099  CXCL8; interleukin-8 [KO:K10030]
100665129  growth-regulated protein homolog gamma-like [KO:K05505]
104846264  CXCL1; growth-regulated alpha protein [KO:K05505]
100675489  C-C motif chemokine 2-like [KO:K14624]
100672636  CCL5; C-C motif chemokine 5 [KO:K12499]
100653643  CAMP; cathelicidin antimicrobial peptide [KO:K13916]
104845913  cathelicidin-related peptide Pt_CRAMP1-like [KO:K13916]
100668357  neutrophil defensin 6-like [KO:K05230]
111751269  beta-defensin 103A-like [KO:K23126]
100677763  NOD2; nucleotide-binding oligomerization domain-containing protein 2 isoform X2 [KO:K10165]
100667170  MAP3K7; mitogen-activated protein kinase kinase kinase 7 isoform X2 [KO:K04427] [EC:2.7.11.25]
100660911  TAB1; LOW QUALITY PROTEIN: TGF-beta-activated kinase 1 and MAP3K7-binding protein 1 [KO:K04403]
100656450  TAB2; TGF-beta-activated kinase 1 and MAP3K7-binding protein 2 isoform X2 [KO:K04404]
100671985  TAB3; TGF-beta-activated kinase 1 and MAP3K7-binding protein 3 [KO:K12793]
100658240  MAPK3; mitogen-activated protein kinase 3 [KO:K04371] [EC:2.7.11.24]
100665157  MAPK1; mitogen-activated protein kinase 1 [KO:K04371] [EC:2.7.11.24]
100654943  MAPK9; mitogen-activated protein kinase 9 isoform X1 [KO:K04440] [EC:2.7.11.24]
100674229  MAPK8; mitogen-activated protein kinase 8 isoform X1 [KO:K04440] [EC:2.7.11.24]
100673395  MAPK10; mitogen-activated protein kinase 10 isoform X1 [KO:K04440] [EC:2.7.11.24]
100673331  MAPK14; mitogen-activated protein kinase 14 isoform X1 [KO:K04441] [EC:2.7.11.24]
100656926  MAPK13; mitogen-activated protein kinase 13 [KO:K04441] [EC:2.7.11.24]
100661039  MAPK12; mitogen-activated protein kinase 12 isoform X1 [KO:K04441] [EC:2.7.11.24]
100670432  JUN; transcription factor AP-1 [KO:K04448]
100663732  ATG16L1; LOW QUALITY PROTEIN: autophagy-related protein 16-1 [KO:K17890]
100660638  ATG5; autophagy protein 5 isoform X4 [KO:K08339]
100660929  ATG12; ubiquitin-like protein ATG12 isoform X1 [KO:K08336]
100659994  GABARAPL1; gamma-aminobutyric acid receptor-associated protein-like 1 [KO:K08341]
100675686  GABARAPL2; gamma-aminobutyric acid receptor-associated protein-like 2 [KO:K08341]
100658035  GABARAP; gamma-aminobutyric acid receptor-associated protein [KO:K08341]
100677670  MAP1LC3B; microtubule-associated proteins 1A/1B light chain 3B [KO:K10435]
100668916  LOW QUALITY PROTEIN: microtubule-associated proteins 1A/1B light chain 3C-like [KO:K10435]
100655546  microtubule-associated proteins 1A/1B light chain 3C-like [KO:K10435]
100661353  SUGT1; protein SGT1 homolog [KO:K12795]
100654220  RBCK1; LOW QUALITY PROTEIN: ranBP-type and C3HC4-type zinc finger-containing protein 1 [KO:K10630] [EC:2.3.2.31]
100653883  RNF31; E3 ubiquitin-protein ligase RNF31 [KO:K11974] [EC:2.3.2.31]
100657657  XIAP; E3 ubiquitin-protein ligase XIAP [KO:K04725] [EC:2.3.2.27]
100660182  CARD6; caspase recruitment domain-containing protein 6 [KO:K12797]
100675431  TRIP6; thyroid receptor-interacting protein 6 [KO:K12792]
100677154  ERBIN; erbin [KO:K12796]
100659163  baculoviral IAP repeat-containing protein 3 [KO:K16060]
100659446  baculoviral IAP repeat-containing protein 2 isoform X1 [KO:K16060]
100670400  TRAF2; TNF receptor-associated factor 2 isoform X2 [KO:K03173] [EC:2.3.2.27]
100663885  TRAF5; TNF receptor-associated factor 5 [KO:K09849]
100671471  TRAF6; TNF receptor-associated factor 6 [KO:K03175] [EC:2.3.2.27]
100658076  CARD9; caspase recruitment domain-containing protein 9 [KO:K12794]
100670852  TNFAIP3; tumor necrosis factor alpha-induced protein 3 [KO:K11859] [EC:3.4.19.12]
100664089  MAVS; mitochondrial antiviral-signaling protein isoform X1 [KO:K12648]
100668716  TRAF3; TNF receptor-associated factor 3 [KO:K03174]
100661026  TBK1; serine/threonine-protein kinase TBK1 [KO:K05410] [EC:2.7.11.10]
100663886  IKBKE; inhibitor of nuclear factor kappa-B kinase subunit epsilon isoform X3 [KO:K07211] [EC:2.7.11.10]
100676764  TANK; TRAF family member-associated NF-kappa-B activator isoform X1 [KO:K12650]
100667571  IRF3; interferon regulatory factor 3 [KO:K05411]
100655418  IRF7; LOW QUALITY PROTEIN: interferon regulatory factor 7 [KO:K09447]
100665583  interferon alpha-5-like [KO:K05414]
100659984  interferon alpha-5-like [KO:K05414]
100660270  interferon alpha-5-like [KO:K05414]
100661986  interferon alpha-5-like [KO:K05414]
100662831  interferon alpha-5-like [KO:K05414]
100663685  interferon alpha-6-like [KO:K05414]
100660554  interferon alpha-5-like [KO:K05414]
100661135  interferon alpha-5-like [KO:K05414]
100666438  IFNB1; interferon beta [KO:K05415]
100658609  NLRX1; NLR family member X1 [KO:K12653]
100656699  ANTXR2; anthrax toxin receptor 2 [KO:K20909]
100672345  ANTXR1; anthrax toxin receptor 1 [KO:K20909]
100653868  LOW QUALITY PROTEIN: NACHT, LRR and PYD domains-containing protein 1 [KO:K12798]
100664299  PYCARD; apoptosis-associated speck-like protein containing a CARD [KO:K12799]
100675268  BCL2; apoptosis regulator Bcl-2 [KO:K02161]
100655646  BCL2L1; bcl-2-like protein 1 isoform X1 [KO:K04570]
100663899  CTSB; cathepsin B [KO:K01363] [EC:3.4.22.1]
100669613  NLRP3; NACHT, LRR and PYD domains-containing protein 3 isoform X1 [KO:K12800]
100672165  PANX1; pannexin-1 [KO:K03443]
100677782  P2RX7; P2X purinoceptor 7 isoform X1 [KO:K05220]
100661004  TRPM2; transient receptor potential cation channel subfamily M member 2 [KO:K04977] [EC:3.6.1.13]
100672088  TRPM7; transient receptor potential cation channel subfamily M member 7 isoform X1 [KO:K04982] [EC:2.7.11.1]
100673719  TRPV2; transient receptor potential cation channel subfamily V member 2 isoform X2 [KO:K04971]
100671950  CASR; extracellular calcium-sensing receptor isoform X2 [KO:K04612]
100668965  GPRC6A; G-protein coupled receptor family C group 6 member A isoform X1 [KO:K04622]
100670617  PLCB4; 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-4 isoform X3 [KO:K05858] [EC:3.1.4.11]
100672435  PLCB1; LOW QUALITY PROTEIN: 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-1 [KO:K05858] [EC:3.1.4.11]
100668575  PLCB2; LOW QUALITY PROTEIN: 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-2 [KO:K05858] [EC:3.1.4.11]
100663829  PLCB3; 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-3 isoform X1 [KO:K05858] [EC:3.1.4.11]
100665028  ITPR1; LOW QUALITY PROTEIN: inositol 1,4,5-trisphosphate receptor type 1 [KO:K04958]
100667845  ITPR2; inositol 1,4,5-trisphosphate receptor type 2 [KO:K04959]
100659666  ITPR3; LOW QUALITY PROTEIN: inositol 1,4,5-trisphosphate receptor type 3 [KO:K04960]
100663098  VDAC1; voltage-dependent anion-selective channel protein 1 [KO:K05862]
100667776  VDAC2; voltage-dependent anion-selective channel protein 2 [KO:K15040]
100656308  VDAC3; voltage-dependent anion-selective channel protein 3 [KO:K15041]
100662469  MCU; calcium uniporter protein, mitochondrial [KO:K20858]
100659469  OAS2; 2'-5'-oligoadenylate synthase 2 [KO:K14216] [EC:2.7.7.84]
104846792  OAS3; 2'-5'-oligoadenylate synthase 3 [KO:K14216] [EC:2.7.7.84]
104846793  OAS1; 2'-5'-oligoadenylate synthase 1 isoform X1 [KO:K14216] [EC:2.7.7.84]
100662757  RNASEL; 2-5A-dependent ribonuclease [KO:K01165]
100676819  DHX33; putative ATP-dependent RNA helicase DHX33 [KO:K17820] [EC:5.6.2.6]
100657365  MFN1; LOW QUALITY PROTEIN: mitofusin-1 [KO:K21356] [EC:3.6.5.-]
100657545  MFN2; mitofusin-2 [KO:K06030] [EC:3.6.5.-]
100666489  RIPK1; receptor-interacting serine/threonine-protein kinase 1 isoform X1 [KO:K02861] [EC:2.7.11.1]
100675807  RIPK3; LOW QUALITY PROTEIN: receptor-interacting serine/threonine-protein kinase 3 [KO:K08847] [EC:2.7.11.1]
100665946  DNM1L; dynamin-1-like protein isoform X1 [KO:K17065] [EC:3.6.5.5]
100656670  NAMPT; nicotinamide phosphoribosyltransferase isoform X2 [KO:K03462] [EC:2.4.2.12]
100655878  cytochrome b-245 heavy chain [KO:K21421] [EC:1.-.-.-]
100666572  cytochrome b-245 light chain [KO:K08009]
100669436  TXNIP; thioredoxin-interacting protein [KO:K20910]
100672083  TXN2; thioredoxin, mitochondrial [KO:K03671]
111749629  TXNDC2; thioredoxin domain-containing protein 2 [KO:K03671]
100668444  NEK7; serine/threonine-protein kinase Nek7 isoform X2 [KO:K20876] [EC:2.7.11.34]
100659672  BRCC3; lys-63-specific deubiquitinase BRCC36 isoform X1 [KO:K11864] [EC:3.4.19.-]
100656361  HSP90AB1; heat shock protein HSP 90-beta [KO:K04079]
100676217  HSP90AA1; LOW QUALITY PROTEIN: heat shock protein HSP 90-alpha [KO:K04079]
100664155  CARD8; caspase recruitment domain-containing protein 8 isoform X1 [KO:K12801]
100656650  GPSM3; G-protein-signaling modulator 3 [KO:K15838]
100667174  IRGM; immunity-related GTPase family M protein isoform X2 [KO:K14139] [EC:3.6.5.-]
100669062  LOW QUALITY PROTEIN: immunity-related GTPase family M protein-like [KO:K14139] [EC:3.6.5.-]
111753054  PYDC1; LOW QUALITY PROTEIN: pyrin domain-containing protein 1 [KO:K12802]
100673509  MEFV; LOW QUALITY PROTEIN: pyrin [KO:K12803]
100672535  PSTPIP1; proline-serine-threonine phosphatase-interacting protein 1 isoform X1 [KO:K12804]
100663575  caspase-8 [KO:K04398] [EC:3.4.22.61]
100660542  CASP8; caspase-8 isoform X1 [KO:K04398] [EC:3.4.22.61]
100662633  FADD; FAS-associated death domain protein [KO:K02373]
100657555  caspase-12-like isoform X1 [KO:K04741] [EC:3.4.22.-]
100657844  LOW QUALITY PROTEIN: caspase-12-like [KO:K04741] [EC:3.4.22.-]
100654203  NLRP6; NACHT, LRR and PYD domains-containing protein 6 [KO:K20863]
100668429  LOW QUALITY PROTEIN: NACHT, LRR and PYD domains-containing protein 7-like [KO:K20864]
100659893  NLRP12; LOW QUALITY PROTEIN: NACHT, LRR and PYD domains-containing protein 12 [KO:K20865]
100661989  NAIP; LOW QUALITY PROTEIN: baculoviral IAP repeat-containing protein 1 [KO:K12807]
100659245  PRKCD; protein kinase C delta type isoform X2 [KO:K06068] [EC:2.7.11.13]
100662758  guanylate-binding protein 2 isoform X1 [KO:K20897]
100661630  guanylate-binding protein 5 isoform X1 [KO:K20898]
100662124  myeloid cell nuclear differentiation antigen-like isoform X2 [KO:K20914]
100653968  TP53BP1; TP53-binding protein 1 isoform X1 [KO:K20915]
111751914  PYDC5; LOW QUALITY PROTEIN: pyrin domain-only protein 3 [KO:K20916]
100677447  RHOA; transforming protein RhoA [KO:K04513]
100675485  PKN1; LOW QUALITY PROTEIN: serine/threonine-protein kinase N1 [KO:K06071] [EC:2.7.11.13]
100664466  PKN2; serine/threonine-protein kinase N2 isoform X1 [KO:K23691] [EC:2.7.11.13]
100658987  YWHAE; 14-3-3 protein epsilon isoform X1 [KO:K06630]
100662482  guanylate-binding protein 4-like [KO:K20899]
100675756  guanylate-binding protein 1 isoform X1 [KO:K20899]
100661347  guanylate-binding protein 4-like [KO:K20899]
100664181  guanylate-binding protein 1-like [KO:K20899]
100663326  LOW QUALITY PROTEIN: guanylate-binding protein 4-like [KO:K20899]
100663607  guanylate-binding protein 4-like isoform X1 [KO:K20899]
100663044  LOW QUALITY PROTEIN: guanylate-binding protein 1-like [KO:K20899]
100663892  LOW QUALITY PROTEIN: guanylate-binding protein 4-like [KO:K20899]
100661933  caspase-1-like [KO:K04394] [EC:3.4.22.57 3.4.22.64]
100676190  GSDMD; gasdermin-D isoform X2 [KO:K20917]
100667586  IFNAR1; interferon alpha/beta receptor 1 [KO:K05130]
100672898  IFNAR2; interferon alpha/beta receptor 2 isoform X2 [KO:K05131]
100655548  JAK1; tyrosine-protein kinase JAK1 [KO:K11217] [EC:2.7.10.2]
100672245  TYK2; non-receptor tyrosine-protein kinase TYK2 [KO:K11219] [EC:2.7.10.2]
100668424  STAT1; signal transducer and activator of transcription 1-alpha/beta [KO:K11220]
100656374  STAT2; signal transducer and activator of transcription 2 [KO:K11221]
100673235  IRF9; interferon regulatory factor 9 isoform X2 [KO:K04693]
100654493  TLR4; toll-like receptor 4 [KO:K10160]
100654083  TICAM1; TIR domain-containing adapter molecule 1 [KO:K05842]
100659447  MYD88; myeloid differentiation primary response protein MyD88 [KO:K04729]
100653528  IRAK4; interleukin-1 receptor-associated kinase 4 [KO:K04733] [EC:2.7.11.1]
100670392  TMEM173; stimulator of interferon genes protein isoform X1 [KO:K12654]
Compound
C00002  ATP
C00076  Calcium cation
C00155  L-Homocysteine
C00238  Potassium cation
C00533  Nitric oxide
C01245  D-myo-Inositol 1,4,5-trisphosphate
Reference
PMID:23124073
  Authors
Vandenabeele P, Bertrand MJ
  Title
The role of the IAP E3 ubiquitin ligases in regulating pattern-recognition receptor signalling.
  Journal
Nat Rev Immunol 12:833-44 (2012)
DOI:10.1038/nri3325
Reference
PMID:16493424
  Authors
Strober W, Murray PJ, Kitani A, Watanabe T
  Title
Signalling pathways and molecular interactions of NOD1 and NOD2.
  Journal
Nat Rev Immunol 6:9-20 (2006)
DOI:10.1038/nri1747
Reference
PMID:24718315
  Authors
Estornes Y, Bertrand MJ
  Title
IAPs, regulators of innate immunity and inflammation.
  Journal
Semin Cell Dev Biol 39:106-14 (2015)
DOI:10.1016/j.semcdb.2014.03.035
Reference
PMID:24707857
  Authors
Jakopin Z
  Title
Nucleotide-binding oligomerization domain (NOD) inhibitors: a rational approach toward inhibition of NOD signaling pathway.
  Journal
J Med Chem 57:6897-918 (2014)
DOI:10.1021/jm401841p
Reference
PMID:25526305
  Authors
Caruso R, Warner N, Inohara N, Nunez G
  Title
NOD1 and NOD2: signaling, host defense, and inflammatory disease.
  Journal
Immunity 41:898-908 (2014)
DOI:10.1016/j.immuni.2014.12.010
Reference
PMID:19767725
  Authors
Murray PJ
  Title
Beyond peptidoglycan for Nod2.
  Journal
Nat Immunol 10:1053-4 (2009)
DOI:10.1038/ni1009-1053
Reference
PMID:20643110
  Authors
Lecat A, Piette J, Legrand-Poels S
  Title
The protein Nod2: an innate receptor more complex than previously assumed.
  Journal
Biochem Pharmacol 80:2021-31 (2010)
DOI:10.1016/j.bcp.2010.07.016
Reference
PMID:26655628
  Authors
Man SM, Kanneganti TD
  Title
Converging roles of caspases in inflammasome activation, cell death and innate immunity.
  Journal
Nat Rev Immunol 16:7-21 (2016)
DOI:10.1038/nri.2015.7
Reference
PMID:27291964
  Authors
Broz P, Dixit VM
  Title
Inflammasomes: mechanism of assembly, regulation and signalling.
  Journal
Nat Rev Immunol 16:407-20 (2016)
DOI:10.1038/nri.2016.58
Reference
PMID:25879280
  Authors
Man SM, Kanneganti TD
  Title
Regulation of inflammasome activation.
  Journal
Immunol Rev 265:6-21 (2015)
DOI:10.1111/imr.12296
Reference
PMID:26549800
  Authors
Jo EK, Kim JK, Shin DM, Sasakawa C
  Title
Molecular mechanisms regulating NLRP3 inflammasome activation.
  Journal
Cell Mol Immunol 13:148-59 (2016)
DOI:10.1038/cmi.2015.95
Reference
PMID:23846113
  Authors
Broz P, Monack DM
  Title
Newly described pattern recognition receptors team up against intracellular pathogens.
  Journal
Nat Rev Immunol 13:551-65 (2013)
DOI:10.1038/nri3479
Reference
PMID:22430786
  Authors
Rathinam VA, Vanaja SK, Fitzgerald KA
  Title
Regulation of inflammasome signaling.
  Journal
Nat Immunol 13:333-42 (2012)
DOI:10.1038/ni.2237
Reference
PMID:24840700
  Authors
Sutterwala FS, Haasken S, Cassel SL
  Title
Mechanism of NLRP3 inflammasome activation.
  Journal
Ann N Y Acad Sci 1319:82-95 (2014)
DOI:10.1111/nyas.12458
Reference
PMID:23702978
  Authors
Latz E, Xiao TS, Stutz A
  Title
Activation and regulation of the inflammasomes.
  Journal
Nat Rev Immunol 13:397-411 (2013)
DOI:10.1038/nri3452
Reference
PMID:25145756
  Authors
Blander JM
  Title
A long-awaited merger of the pathways mediating host defence and programmed cell death.
  Journal
Nat Rev Immunol 14:601-18 (2014)
DOI:10.1038/nri3720
Reference
PMID:23215645
  Authors
von Moltke J, Ayres JS, Kofoed EM, Chavarria-Smith J, Vance RE
  Title
Recognition of bacteria by inflammasomes.
  Journal
Annu Rev Immunol 31:73-106 (2013)
DOI:10.1146/annurev-immunol-032712-095944
Reference
PMID:25330206
  Authors
Abais JM, Xia M, Zhang Y, Boini KM, Li PL
  Title
Redox regulation of NLRP3 inflammasomes: ROS as trigger or effector?
  Journal
Antioxid Redox Signal 22:1111-29 (2015)
DOI:10.1089/ars.2014.5994
Reference
PMID:25879288
  Authors
Storek KM, Monack DM
  Title
Bacterial recognition pathways that lead to inflammasome activation.
  Journal
Immunol Rev 265:112-29 (2015)
DOI:10.1111/imr.12289
Reference
PMID:27012466
  Authors
Hu H, Sun SC
  Title
Ubiquitin signaling in immune responses.
  Journal
Cell Res 26:457-83 (2016)
DOI:10.1038/cr.2016.40
Reference
PMID:26121197
  Authors
Guo H, Callaway JB, Ting JP
  Title
Inflammasomes: mechanism of action, role in disease, and therapeutics.
  Journal
Nat Med 21:677-87 (2015)
DOI:10.1038/nm.3893
Reference
PMID:26482951
  Authors
Man SM, Kanneganti TD
  Title
Gasdermin D: the long-awaited executioner of pyroptosis.
  Journal
Cell Res 25:1183-4 (2015)
DOI:10.1038/cr.2015.124
Reference
PMID:22819539
  Authors
Rathinam VA, Vanaja SK, Waggoner L, Sokolovska A, Becker C, Stuart LM, Leong JM, Fitzgerald KA
  Title
TRIF licenses caspase-11-dependent NLRP3 inflammasome activation by gram-negative bacteria.
  Journal
Cell 150:606-19 (2012)
DOI:10.1016/j.cell.2012.07.007
Reference
PMID:21575908
  Authors
Kerur N, Veettil MV, Sharma-Walia N, Bottero V, Sadagopan S, Otageri P, Chandran B
  Title
IFI16 acts as a nuclear pathogen sensor to induce the inflammasome in response to Kaposi Sarcoma-associated herpesvirus infection.
  Journal
Cell Host Microbe 9:363-75 (2011)
DOI:10.1016/j.chom.2011.04.008
Reference
PMID:29148036
  Authors
Heilig R, Broz P
  Title
Function and mechanism of the pyrin inflammasome.
  Journal
Eur J Immunol 48:230-238 (2018)
DOI:10.1002/eji.201746947
Reference
PMID:25816776
  Authors
Chakrabarti A, Banerjee S, Franchi L, Loo YM, Gale M Jr, Nunez G, Silverman RH
  Title
RNase L activates the NLRP3 inflammasome during viral infections.
  Journal
Cell Host Microbe 17:466-77 (2015)
DOI:10.1016/j.chom.2015.02.010
Related
pathway
lav04010  MAPK signaling pathway
lav04064  NF-kappa B signaling pathway
lav04140  Autophagy - animal
lav04620  Toll-like receptor signaling pathway
KO pathway
ko04621   
LinkDB

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