KEGG   PATHWAY: mbez04621
Entry
mbez04621                   Pathway                                
Name
NOD-like receptor signaling pathway - Moschus berezovskii (Chinese forest musk deer)
Description
Specific families of pattern recognition receptors are responsible for detecting various pathogens and generating innate immune responses. The intracellular NOD-like receptor (NLR) family contains more than 20 members in mammals and plays a pivotal role in the recognition of intracellular ligands. NOD1 and NOD2, two prototypic NLRs, sense the cytosolic presence of the bacterial peptidoglycan fragments that escaped from endosomal compartments, driving the activation of NF-{kappa}B and MAPK, cytokine production and apoptosis. On the other hand, a different set of NLRs induces caspase-1 activation through the assembly of multiprotein complexes called inflammasomes. The activated of caspase-1 regulates maturation of the pro-inflammatory cytokines IL-1B, IL-18 and drives pyroptosis.
Class
Organismal Systems; Immune system
Pathway map
mbez04621  NOD-like receptor signaling pathway
mbez04621

Organism
Moschus berezovskii (Chinese forest musk deer) [GN:mbez]
Gene
129552487  NOD1; nucleotide-binding oligomerization domain-containing protein 1 [KO:K08727]
129559967  RIPK2; receptor-interacting serine/threonine-protein kinase 2 [KO:K08846] [EC:2.7.11.1]
129564146  IKBKG; NF-kappa-B essential modulator isoform X1 [KO:K07210]
129555451  CHUK; inhibitor of nuclear factor kappa-B kinase subunit alpha isoform X1 [KO:K04467] [EC:2.7.11.10]
129549430  IKBKB; inhibitor of nuclear factor kappa-B kinase subunit beta [KO:K07209] [EC:2.7.11.10]
129546849  NFKBIB; NF-kappa-B inhibitor beta isoform X1 [KO:K02581]
129550521  NFKBIA; NF-kappa-B inhibitor alpha [KO:K04734]
129562101  NFKB1; nuclear factor NF-kappa-B p105 subunit isoform X1 [KO:K02580]
129548767  RELA; transcription factor p65 [KO:K04735]
129539906  IL1B; interleukin-1 beta [KO:K04519]
129554333  IL18; interleukin-18 isoform X1 [KO:K05482]
129543262  TNF; tumor necrosis factor isoform X1 [KO:K03156]
129562064  CXCL8; interleukin-8 [KO:K10030]
129561737  growth-regulated protein homolog beta [KO:K05505]
129562028  growth-regulated protein homolog beta-like [KO:K05505]
129562061  growth-regulated protein homolog gamma-like [KO:K05505]
129536764  C-C motif chemokine 2 [KO:K14624]
129536712  CCL5; C-C motif chemokine 5 [KO:K12499]
129547589  cathelicidin-3-like [KO:K13916]
129547590  cathelicidin-4-like [KO:K13916]
129547591  cathelicidin-3-like [KO:K13916]
129547593  cathelicidin-4-like [KO:K13916]
129547594  cathelicidin-4-like [KO:K13916]
129547596  cathelicidin-4-like [KO:K13916]
129547597  cathelicidin-4-like [KO:K13916]
129547793  cathelicidin-5 [KO:K13916]
129547794  cathelicidin-6 [KO:K13916]
129547796  cathelicidin-7-like [KO:K13916]
129547114  NOD2; nucleotide-binding oligomerization domain-containing protein 2 isoform X1 [KO:K10165]
129560795  MAP3K7; mitogen-activated protein kinase kinase kinase 7 [KO:K04427] [EC:2.7.11.25]
129535825  TAB1; TGF-beta-activated kinase 1 and MAP3K7-binding protein 1 [KO:K04403]
129560692  TAB2; TGF-beta-activated kinase 1 and MAP3K7-binding protein 2 [KO:K04404]
129564156  TAB3; TGF-beta-activated kinase 1 and MAP3K7-binding protein 3 isoform X1 [KO:K12793]
129542485  MAPK1; mitogen-activated protein kinase 1 [KO:K04371] [EC:2.7.11.24]
129545501  MAPK3; mitogen-activated protein kinase 3 [KO:K04371] [EC:2.7.11.24]
129559467  MAPK9; mitogen-activated protein kinase 9 isoform X1 [KO:K04440] [EC:2.7.11.24]
129561625  MAPK10; mitogen-activated protein kinase 10 [KO:K04440] [EC:2.7.11.24]
129555633  MAPK8; mitogen-activated protein kinase 8 isoform X1 [KO:K04440] [EC:2.7.11.24]
129537071  MAPK12; mitogen-activated protein kinase 12 isoform X1 [KO:K04441] [EC:2.7.11.24]
129537073  MAPK11; mitogen-activated protein kinase 11 isoform X1 [KO:K04441] [EC:2.7.11.24]
129543604  MAPK13; mitogen-activated protein kinase 13 [KO:K04441] [EC:2.7.11.24]
129543888  MAPK14; mitogen-activated protein kinase 14 isoform X1 [KO:K04441] [EC:2.7.11.24]
129545108  mitogen-activated protein kinase 14-like [KO:K04441] [EC:2.7.11.24]
129540610  JUN; transcription factor Jun [KO:K04448]
129540655  ATG16L1; autophagy-related protein 16-1 isoform X1 [KO:K17890]
129560712  ATG5; autophagy protein 5 [KO:K08339]
129562434  ATG12; ubiquitin-like protein ATG12 [KO:K08336]
129535768  GABARAPL1; gamma-aminobutyric acid receptor-associated protein-like 1 isoform X1 [KO:K08341]
129542675  GABARAP; gamma-aminobutyric acid receptor-associated protein [KO:K08341]
129547253  GABARAPL2; gamma-aminobutyric acid receptor-associated protein-like 2 [KO:K08341]
129551102  MAP1LC3C; microtubule-associated proteins 1A/1B light chain 3C [KO:K10435]
129547187  MAP1LC3B; microtubule-associated proteins 1A/1B light chain 3B [KO:K10435]
129562623  MAP1LC3A; microtubule-associated proteins 1A/1B light chain 3A [KO:K10435]
129556215  SUGT1; protein SGT1 homolog isoform X1 [KO:K12795]
129560231  sharpin [KO:K20894]
129561959  RBCK1; ranBP-type and C3HC4-type zinc finger-containing protein 1 isoform X1 [KO:K10630] [EC:2.3.2.31]
129562922  RNF31; E3 ubiquitin-protein ligase RNF31 [KO:K11974] [EC:2.3.2.31]
129564296  XIAP; E3 ubiquitin-protein ligase XIAP [KO:K04725] [EC:2.3.2.27]
129545668  TRIP6; thyroid receptor-interacting protein 6 [KO:K12792]
129553214  ERBIN; erbin isoform X1 [KO:K12796]
129564389  LOW QUALITY PROTEIN: baculoviral IAP repeat-containing protein 2-like [KO:K16060]
129554248  baculoviral IAP repeat-containing protein 2 isoform X1 [KO:K16060]
129554250  BIRC3; baculoviral IAP repeat-containing protein 3 [KO:K16060]
129539173  TRAF2; TNF receptor-associated factor 2 isoform X1 [KO:K03173] [EC:2.3.2.27]
129551247  TRAF5; TNF receptor-associated factor 5 isoform X1 [KO:K09849]
129554762  TRAF6; TNF receptor-associated factor 6 [KO:K03175] [EC:2.3.2.27]
129539247  CARD9; caspase recruitment domain-containing protein 9 [KO:K12794]
129560981  TNFAIP3; tumor necrosis factor alpha-induced protein 3 [KO:K11859] [EC:3.4.19.12]
129560195  MAVS; mitochondrial antiviral-signaling protein isoform X1 [KO:K12648]
129550678  TRAF3; TNF receptor-associated factor 3 [KO:K03174]
129536260  TBK1; serine/threonine-protein kinase TBK1 isoform X1 [KO:K05410] [EC:2.7.11.10]
129551739  IKBKE; inhibitor of nuclear factor kappa-B kinase subunit epsilon isoform X1 [KO:K07211] [EC:2.7.11.10]
129537507  TANK; TRAF family member-associated NF-kappa-B activator isoform X1 [KO:K12650]
129546536  IRF3; interferon regulatory factor 3 isoform X1 [KO:K05411]
129548601  IRF7; interferon regulatory factor 7 isoform X1 [KO:K09447]
129557109  LOW QUALITY PROTEIN: interferon alpha-2-like [KO:K05414]
129557111  LOW QUALITY PROTEIN: interferon alpha-2-like [KO:K05414]
129557266  interferon alpha-1-like [KO:K05414]
129557270  interferon alpha-1-like [KO:K05414]
129557271  interferon alpha-1 [KO:K05414]
129557272  interferon alpha-1-like [KO:K05414]
129557274  interferon alpha-1-like [KO:K05414]
129557279  interferon alpha-1-like [KO:K05414]
129557285  interferon alpha-1-like [KO:K05414]
129557286  interferon alpha-H [KO:K05414]
129557110  interferon beta-2-like [KO:K05415]
129557288  interferon beta-2 [KO:K05415]
129557307  interferon beta-2-like [KO:K05415]
129557308  interferon beta-2-like [KO:K05415]
129554413  NLRX1; NLR family member X1 isoform X1 [KO:K12653]
129554427  LOW QUALITY PROTEIN: NLR family member X1-like [KO:K12653]
129539714  ANTXR1; anthrax toxin receptor 1 [KO:K20909]
129561456  ANTXR2; anthrax toxin receptor 2 [KO:K20909]
129542099  NLRP1; NACHT, LRR and PYD domains-containing protein 1 isoform X1 [KO:K12798]
129545563  apoptosis-associated speck-like protein containing a CARD [KO:K12799]
129554236  caspase-1-like isoform X1 [KO:K01370] [EC:3.4.22.36]
129549902  BCL2; apoptosis regulator Bcl-2 isoform X1 [KO:K02161]
129538419  bcl-2-like protein 1 [KO:K04570]
129562040  BCL2L1; bcl-2-like protein 1 [KO:K04570]
129557483  CTSB; cathepsin B [KO:K01363] [EC:3.4.22.1]
129559046  NLRP3; NACHT, LRR and PYD domains-containing protein 3 [KO:K12800]
129548393  PANX1; pannexin-1 [KO:K03443]
129542778  P2RX7; P2X purinoceptor 7 [KO:K05220]
129548396  TRPM2; transient receptor potential cation channel subfamily M member 2 [KO:K04977] [EC:3.6.1.13]
129563605  TRPM7; transient receptor potential cation channel subfamily M member 7 [KO:K04982] [EC:2.7.11.1]
129544179  TRPV2; transient receptor potential cation channel subfamily V member 2 isoform X1 [KO:K04971]
129550635  CASR; extracellular calcium-sensing receptor [KO:K04612]
129560842  GPRC6A; LOW QUALITY PROTEIN: G-protein coupled receptor family C group 6 member A [KO:K04622]
129548814  PLCB3; 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-3 isoform X1 [KO:K05858] [EC:3.1.4.11]
129563187  PLCB2; 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-2 isoform X1 [KO:K05858] [EC:3.1.4.11]
129556526  PLCB4; 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-4 isoform X1 [KO:K05858] [EC:3.1.4.11]
129556560  PLCB1; 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-1 isoform X1 [KO:K05858] [EC:3.1.4.11]
129548039  ITPR1; inositol 1,4,5-trisphosphate receptor type 1 [KO:K04958]
129536224  ITPR2; inositol 1,4,5-trisphosphate receptor type 2 isoform X1 [KO:K04959]
129543844  ITPR3; inositol 1,4,5-trisphosphate receptor type 3 isoform X1 [KO:K04960]
129558217  VDAC1; voltage-dependent anion-selective channel protein 1 [KO:K05862]
129555687  VDAC2; voltage-dependent anion-selective channel protein 2 [KO:K15040]
129549434  VDAC3; voltage-dependent anion-selective channel protein 3 [KO:K15041]
129560157  voltage-dependent anion-selective channel protein 3-like [KO:K15041]
129562882  voltage-dependent anion-selective channel protein 3-like [KO:K15041]
129555725  MCU; calcium uniporter protein, mitochondrial isoform X1 [KO:K20858]
129551309  RNASEL; 2-5A-dependent ribonuclease [KO:K01165]
129542160  DHX33; ATP-dependent RNA helicase DHX33 isoform X1 [KO:K17820] [EC:5.6.2.6]
129551548  MFN2; mitofusin-2 [KO:K06030] [EC:3.6.5.-]
129543713  RIPK1; receptor-interacting serine/threonine-protein kinase 1 [KO:K02861] [EC:2.7.11.1]
129562625  RIPK3; receptor-interacting serine/threonine-protein kinase 3 [KO:K08847] [EC:2.7.11.1]
129535643  DNM1L; dynamin-1-like protein isoform X1 [KO:K17065] [EC:3.6.5.5]
129552389  NAMPT; nicotinamide phosphoribosyltransferase [KO:K03462] [EC:2.4.2.12]
129564517  cytochrome b-245 heavy chain [KO:K21421] [EC:1.-.-.-]
129547179  cytochrome b-245 light chain [KO:K08009]
129540660  TXNIP; thioredoxin-interacting protein [KO:K20910]
129535717  TXN2; thioredoxin, mitochondrial [KO:K03671]
129557163  thioredoxin-like [KO:K03671]
129540266  thioredoxin [KO:K03671]
129551210  NEK7; serine/threonine-protein kinase Nek7 [KO:K20876] [EC:2.7.11.34]
129564217  BRCC3; lys-63-specific deubiquitinase BRCC36 isoform X1 [KO:K11864] [EC:3.4.19.-]
129555160  LOW QUALITY PROTEIN: lys-63-specific deubiquitinase BRCC36-like [KO:K11864] [EC:3.4.19.-]
129549628  LOW QUALITY PROTEIN: uncharacterized protein LOC129549628 [KO:K04079]
129543247  HSP90AB1; heat shock protein HSP 90-beta [KO:K04079]
129550661  LOW QUALITY PROTEIN: heat shock protein HSP 90-beta-like [KO:K04079]
129550665  HSP90AA1; heat shock protein HSP 90-alpha [KO:K04079]
129535215  LOW QUALITY PROTEIN: heat shock protein HSP 90-alpha-like [KO:K04079]
129543131  GPSM3; G-protein-signaling modulator 3 [KO:K15838]
129545308  MEFV; LOW QUALITY PROTEIN: pyrin [KO:K12803]
129550424  PSTPIP1; proline-serine-threonine phosphatase-interacting protein 1 isoform X1 [KO:K12804]
129538041  CASP8; caspase-8 [KO:K04398] [EC:3.4.22.61]
129548659  FADD; FAS-associated death domain protein [KO:K02373]
129548314  NLRP6; NACHT, LRR and PYD domains-containing protein 6 [KO:K20863]
129545957  NLRP7; NACHT, LRR and PYD domains-containing protein 7 [KO:K20864]
129546406  NLRP12; NACHT, LRR and PYD domains-containing protein 12 isoform X1 [KO:K20865]
129553195  NAIP; LOW QUALITY PROTEIN: baculoviral IAP repeat-containing protein 1 [KO:K12807]
129539869  NLRC4; LOW QUALITY PROTEIN: NLR family CARD domain-containing protein 4 [KO:K12805]
129547928  PRKCD; protein kinase C delta type [KO:K06068] [EC:2.7.11.13]
129541158  guanylate-binding protein 2-like [KO:K20897]
129541063  guanylate-binding protein 5-like isoform X1 [KO:K20898]
129541096  interferon-activable protein 203-like [KO:K20914]
129550561  TP53BP1; TP53-binding protein 1 isoform X1 [KO:K20915]
129539448  transforming protein RhoA-like [KO:K04513]
129547838  RHOA; transforming protein RhoA [KO:K04513]
129558503  PKN1; serine/threonine-protein kinase N1 isoform X1 [KO:K06071] [EC:2.7.11.13]
129541704  PKN2; serine/threonine-protein kinase N2 [KO:K23691] [EC:2.7.11.13]
129541281  YWHAE; 14-3-3 protein epsilon isoform X1 [KO:K06630]
129540748  guanylate-binding protein 4-like [KO:K20899]
129541170  guanylate-binding protein 1-like [KO:K20899]
129541835  guanylate-binding protein 4-like isoform X1 [KO:K20899]
129541836  guanylate-binding protein 1-like [KO:K20899]
129554237  caspase-13 isoform X1 [KO:K04394] [EC:3.4.22.57 3.4.22.64]
129560224  GSDMD; gasdermin-D isoform X1 [KO:K20917]
129552638  interferon alpha/beta receptor 2 isoform X1 [KO:K05131]
129541821  JAK1; tyrosine-protein kinase JAK1 [KO:K11217] [EC:2.7.10.2]
129558611  TYK2; non-receptor tyrosine-protein kinase TYK2 isoform X1 [KO:K11219] [EC:2.7.10.2]
129537915  STAT1; signal transducer and activator of transcription 1-alpha/beta [KO:K11220]
129537127  STAT2; signal transducer and activator of transcription 2 [KO:K11221]
129562923  IRF9; interferon regulatory factor 9 isoform X1 [KO:K04693]
129557207  TLR4; toll-like receptor 4 [KO:K10160]
129558739  TICAM1; TIR domain-containing adapter molecule 1 [KO:K05842]
129548144  MYD88; myeloid differentiation primary response protein MyD88 [KO:K04729]
129536594  IRAK4; interleukin-1 receptor-associated kinase 4 isoform X1 [KO:K04733] [EC:2.7.11.1]
129558440  STING1; stimulator of interferon genes protein isoform X1 [KO:K12654]
Compound
C00002  ATP
C00076  Calcium cation
C00155  L-Homocysteine
C00238  Potassium cation
C00533  Nitric oxide
C01245  D-myo-Inositol 1,4,5-trisphosphate
Reference
PMID:23124073
  Authors
Vandenabeele P, Bertrand MJ
  Title
The role of the IAP E3 ubiquitin ligases in regulating pattern-recognition receptor signalling.
  Journal
Nat Rev Immunol 12:833-44 (2012)
DOI:10.1038/nri3325
Reference
PMID:16493424
  Authors
Strober W, Murray PJ, Kitani A, Watanabe T
  Title
Signalling pathways and molecular interactions of NOD1 and NOD2.
  Journal
Nat Rev Immunol 6:9-20 (2006)
DOI:10.1038/nri1747
Reference
PMID:24718315
  Authors
Estornes Y, Bertrand MJ
  Title
IAPs, regulators of innate immunity and inflammation.
  Journal
Semin Cell Dev Biol 39:106-14 (2015)
DOI:10.1016/j.semcdb.2014.03.035
Reference
PMID:24707857
  Authors
Jakopin Z
  Title
Nucleotide-binding oligomerization domain (NOD) inhibitors: a rational approach toward inhibition of NOD signaling pathway.
  Journal
J Med Chem 57:6897-918 (2014)
DOI:10.1021/jm401841p
Reference
PMID:25526305
  Authors
Caruso R, Warner N, Inohara N, Nunez G
  Title
NOD1 and NOD2: signaling, host defense, and inflammatory disease.
  Journal
Immunity 41:898-908 (2014)
DOI:10.1016/j.immuni.2014.12.010
Reference
PMID:19767725
  Authors
Murray PJ
  Title
Beyond peptidoglycan for Nod2.
  Journal
Nat Immunol 10:1053-4 (2009)
DOI:10.1038/ni1009-1053
Reference
PMID:20643110
  Authors
Lecat A, Piette J, Legrand-Poels S
  Title
The protein Nod2: an innate receptor more complex than previously assumed.
  Journal
Biochem Pharmacol 80:2021-31 (2010)
DOI:10.1016/j.bcp.2010.07.016
Reference
PMID:26655628
  Authors
Man SM, Kanneganti TD
  Title
Converging roles of caspases in inflammasome activation, cell death and innate immunity.
  Journal
Nat Rev Immunol 16:7-21 (2016)
DOI:10.1038/nri.2015.7
Reference
PMID:27291964
  Authors
Broz P, Dixit VM
  Title
Inflammasomes: mechanism of assembly, regulation and signalling.
  Journal
Nat Rev Immunol 16:407-20 (2016)
DOI:10.1038/nri.2016.58
Reference
PMID:25879280
  Authors
Man SM, Kanneganti TD
  Title
Regulation of inflammasome activation.
  Journal
Immunol Rev 265:6-21 (2015)
DOI:10.1111/imr.12296
Reference
PMID:26549800
  Authors
Jo EK, Kim JK, Shin DM, Sasakawa C
  Title
Molecular mechanisms regulating NLRP3 inflammasome activation.
  Journal
Cell Mol Immunol 13:148-59 (2016)
DOI:10.1038/cmi.2015.95
Reference
PMID:23846113
  Authors
Broz P, Monack DM
  Title
Newly described pattern recognition receptors team up against intracellular pathogens.
  Journal
Nat Rev Immunol 13:551-65 (2013)
DOI:10.1038/nri3479
Reference
PMID:22430786
  Authors
Rathinam VA, Vanaja SK, Fitzgerald KA
  Title
Regulation of inflammasome signaling.
  Journal
Nat Immunol 13:333-42 (2012)
DOI:10.1038/ni.2237
Reference
PMID:24840700
  Authors
Sutterwala FS, Haasken S, Cassel SL
  Title
Mechanism of NLRP3 inflammasome activation.
  Journal
Ann N Y Acad Sci 1319:82-95 (2014)
DOI:10.1111/nyas.12458
Reference
PMID:23702978
  Authors
Latz E, Xiao TS, Stutz A
  Title
Activation and regulation of the inflammasomes.
  Journal
Nat Rev Immunol 13:397-411 (2013)
DOI:10.1038/nri3452
Reference
PMID:25145756
  Authors
Blander JM
  Title
A long-awaited merger of the pathways mediating host defence and programmed cell death.
  Journal
Nat Rev Immunol 14:601-18 (2014)
DOI:10.1038/nri3720
Reference
PMID:23215645
  Authors
von Moltke J, Ayres JS, Kofoed EM, Chavarria-Smith J, Vance RE
  Title
Recognition of bacteria by inflammasomes.
  Journal
Annu Rev Immunol 31:73-106 (2013)
DOI:10.1146/annurev-immunol-032712-095944
Reference
PMID:25330206
  Authors
Abais JM, Xia M, Zhang Y, Boini KM, Li PL
  Title
Redox regulation of NLRP3 inflammasomes: ROS as trigger or effector?
  Journal
Antioxid Redox Signal 22:1111-29 (2015)
DOI:10.1089/ars.2014.5994
Reference
PMID:25879288
  Authors
Storek KM, Monack DM
  Title
Bacterial recognition pathways that lead to inflammasome activation.
  Journal
Immunol Rev 265:112-29 (2015)
DOI:10.1111/imr.12289
Reference
PMID:27012466
  Authors
Hu H, Sun SC
  Title
Ubiquitin signaling in immune responses.
  Journal
Cell Res 26:457-83 (2016)
DOI:10.1038/cr.2016.40
Reference
PMID:26121197
  Authors
Guo H, Callaway JB, Ting JP
  Title
Inflammasomes: mechanism of action, role in disease, and therapeutics.
  Journal
Nat Med 21:677-87 (2015)
DOI:10.1038/nm.3893
Reference
PMID:26482951
  Authors
Man SM, Kanneganti TD
  Title
Gasdermin D: the long-awaited executioner of pyroptosis.
  Journal
Cell Res 25:1183-4 (2015)
DOI:10.1038/cr.2015.124
Reference
PMID:22819539
  Authors
Rathinam VA, Vanaja SK, Waggoner L, Sokolovska A, Becker C, Stuart LM, Leong JM, Fitzgerald KA
  Title
TRIF licenses caspase-11-dependent NLRP3 inflammasome activation by gram-negative bacteria.
  Journal
Cell 150:606-19 (2012)
DOI:10.1016/j.cell.2012.07.007
Reference
PMID:21575908
  Authors
Kerur N, Veettil MV, Sharma-Walia N, Bottero V, Sadagopan S, Otageri P, Chandran B
  Title
IFI16 acts as a nuclear pathogen sensor to induce the inflammasome in response to Kaposi Sarcoma-associated herpesvirus infection.
  Journal
Cell Host Microbe 9:363-75 (2011)
DOI:10.1016/j.chom.2011.04.008
Reference
PMID:29148036
  Authors
Heilig R, Broz P
  Title
Function and mechanism of the pyrin inflammasome.
  Journal
Eur J Immunol 48:230-238 (2018)
DOI:10.1002/eji.201746947
Reference
PMID:25816776
  Authors
Chakrabarti A, Banerjee S, Franchi L, Loo YM, Gale M Jr, Nunez G, Silverman RH
  Title
RNase L activates the NLRP3 inflammasome during viral infections.
  Journal
Cell Host Microbe 17:466-77 (2015)
DOI:10.1016/j.chom.2015.02.010
Related
pathway
mbez04010  MAPK signaling pathway
mbez04064  NF-kappa B signaling pathway
mbez04140  Autophagy - animal
mbez04620  Toll-like receptor signaling pathway
KO pathway
ko04621   
LinkDB

DBGET integrated database retrieval system