KEGG   PATHWAY: nle04936
Entry
nle04936                    Pathway                                
Name
Alcoholic liver disease - Nomascus leucogenys (northern white-cheeked gibbon)
Description
Alcoholic liver disease (ALD) refers to the damages to the liver and its functions due to alcohol overconsumption. It ranges from simple steatosis to steatohepatitis, cirrhosis, and even hepatocellular carcinoma. Alcohol consumption promotes liver inflammation by increasing the translocation of gut-derived endotoxins to the portal circulation and activating Kupffer cells to produce TNF-alpha through the LPS/Toll like receptor (TLR) 4 pathways. TNF-alpha induces hepatocellular damage. When alcohol intake is chronic and heavy, steatosis is caused via generation of acetaldehyde, reactive oxygen species (ROS) and ER stress. ROS inhibits key hepatic transcriptional regulators such as AMP-activated kinase (AMPK) and peroxisome proliferator-activated receptor alpha (PPAR-alpha), which are responsible for fatty acid oxidation and export via ACC and CPT-1. The blockade of AMPK also leads to overexpression of SREBP-1, resulting in an increase of de novo lipogenesis. Moreover, excessive intracellular ROS production induced by ethanol and its metabolite have a critical role in ethanol-induced apoptosis, which may be the critical process in the exacerbation of ALD. It is inferred that the apoptotic signal derived from ROS that was produced by NOX, is mainly transduced through the JNK and p38 MAPK pathways.
Class
Human Diseases; Endocrine and metabolic disease
Pathway map
nle04936  Alcoholic liver disease
nle04936

Organism
Nomascus leucogenys (northern white-cheeked gibbon) [GN:nle]
Gene
100606692  C1QA; complement C1q subcomponent subunit A [KO:K03986]
100607840  C1QB; complement C1q subcomponent subunit B [KO:K03987]
100607041  C1QC; complement C1q subcomponent subunit C isoform X1 [KO:K03988]
100606928  C2; complement C2 isoform X1 [KO:K01332] [EC:3.4.21.43]
100596445  complement C4-B isoform X2 [KO:K03989]
100598784  C3; complement C3 [KO:K03990]
100588722  C3AR1; C3a anaphylatoxin chemotactic receptor [KO:K04009]
100606437  C5; complement C5 isoform X2 [KO:K03994]
100589337  C5AR1; C5a anaphylatoxin chemotactic receptor 1 [KO:K04010]
100579295  LBP; lipopolysaccharide-binding protein [KO:K05399]
100605324  CD14; monocyte differentiation antigen CD14 [KO:K04391]
100600389  LY96; lymphocyte antigen 96 [KO:K05400]
100601154  TLR4; toll-like receptor 4 isoform X1 [KO:K10160]
100601986  TIRAP; toll/interleukin-1 receptor domain-containing adapter protein isoform X2 [KO:K05403]
100598173  MYD88; myeloid differentiation primary response protein MyD88 isoform X2 [KO:K04729]
100602648  IRAK4; interleukin-1 receptor-associated kinase 4 isoform X2 [KO:K04733] [EC:2.7.11.1]
100588136  IRAK1; interleukin-1 receptor-associated kinase 1 isoform X1 [KO:K04730] [EC:2.7.11.1]
100595327  TRAF6; TNF receptor-associated factor 6 isoform X1 [KO:K03175] [EC:2.3.2.27]
100587157  TAB1; TGF-beta-activated kinase 1 and MAP3K7-binding protein 1 [KO:K04403]
100597932  TAB2; TGF-beta-activated kinase 1 and MAP3K7-binding protein 2 [KO:K04404]
100596471  MAP3K7; mitogen-activated protein kinase kinase kinase 7 isoform X1 [KO:K04427] [EC:2.7.11.25]
100596225  CHUK; inhibitor of nuclear factor kappa-B kinase subunit alpha isoform X1 [KO:K04467] [EC:2.7.11.10]
100588081  IKBKB; inhibitor of nuclear factor kappa-B kinase subunit beta isoform X1 [KO:K07209] [EC:2.7.11.10]
100603768  IKBKG; NF-kappa-B essential modulator isoform X1 [KO:K07210]
100599351  NFKBIA; NF-kappa-B inhibitor alpha [KO:K04734]
100588439  RELA; transcription factor p65 [KO:K04735]
100581655  NFKB1; nuclear factor NF-kappa-B p105 subunit isoform X1 [KO:K02580]
100583968  TNF; tumor necrosis factor [KO:K03156]
100587357  IL1B; interleukin-1 beta [KO:K04519]
100586527  IL6; interleukin-6 isoform X2 [KO:K05405]
100603245  IL12A; interleukin-12 subunit alpha isoform X1 [KO:K05406]
100579267  interleukin-12 subunit beta [KO:K05425]
115837257  interleukin-12 subunit beta-like [KO:K05425]
100586157  CXCL8; interleukin-8 [KO:K10030]
100588929  TICAM1; TIR domain-containing adapter molecule 1 [KO:K05842]
100606382  TRAF3; TNF receptor-associated factor 3 isoform X1 [KO:K03174]
100605137  IKBKE; inhibitor of nuclear factor kappa-B kinase subunit epsilon [KO:K07211] [EC:2.7.11.10]
100582856  TBK1; serine/threonine-protein kinase TBK1 [KO:K05410] [EC:2.7.11.10]
100603099  IRF3; interferon regulatory factor 3 isoform X1 [KO:K05411]
100597957  interferon alpha-10-like [KO:K05414]
100596272  IFNA6; interferon alpha-6 [KO:K05414]
100595254  IFNA8; interferon alpha-8 [KO:K05414]
100597288  interferon alpha-14 [KO:K05414]
100596946  interferon alpha-5 [KO:K05414]
100598307  interferon alpha-10 [KO:K05414]
100595932  interferon alpha-1/13 [KO:K05414]
100594907  interferon alpha-1/13 [KO:K05414]
100597620  interferon alpha-4 [KO:K05414]
100595585  IFNA2; interferon alpha-2 [KO:K05414]
100598986  IFNB1; interferon beta [KO:K05415]
100589095  IL17A; interleukin-17A [KO:K05489]
100592393  IL17RA; interleukin-17 receptor A [KO:K05164]
100606902  IL17RC; interleukin-17 receptor C isoform X1 [KO:K05166]
100592551  CXCL2; C-X-C motif chemokine 2 isoform X2 [KO:K05505]
100588392  CXCL3; C-X-C motif chemokine 3 [KO:K05505]
100591876  CXCL1; growth-regulated alpha protein [KO:K05505]
100597719  FASLG; tumor necrosis factor ligand superfamily member 6 isoform X1 [KO:K04389]
100580318  FAS; tumor necrosis factor receptor superfamily member 6 isoform X1 [KO:K04390]
100607557  FADD; FAS-associated death domain protein [KO:K02373]
100581749  TNFRSF1A; tumor necrosis factor receptor superfamily member 1A isoform X4 [KO:K03158]
100607674  TRADD; tumor necrosis factor receptor type 1-associated DEATH domain protein isoform X1 [KO:K03171]
100586183  CASP8; caspase-8 isoform X1 [KO:K04398] [EC:3.4.22.61]
100585064  CASP3; caspase-3 isoform X3 [KO:K02187] [EC:3.4.22.56]
100599272  RIPK1; receptor-interacting serine/threonine-protein kinase 1 isoform X1 [KO:K02861] [EC:2.7.11.1]
100580022  TAB3; TGF-beta-activated kinase 1 and MAP3K7-binding protein 3 isoform X1 [KO:K12793]
100591724  SREBF1; sterol regulatory element-binding protein 1 isoform X3 [KO:K07197]
100597701  FASN; fatty acid synthase [KO:K00665] [EC:2.3.1.85]
100596750  LOW QUALITY PROTEIN: fatty acid synthase-like [KO:K00665] [EC:2.3.1.85]
100588574  ACACA; acetyl-CoA carboxylase 1 isoform X1 [KO:K11262] [EC:6.4.1.2 6.3.4.14 2.1.3.15]
100602453  SCD; acyl-CoA desaturase [KO:K00507] [EC:1.14.19.1]
100599363  SCD5; stearoyl-CoA desaturase 5 [KO:K00507] [EC:1.14.19.1]
100584244  LPIN2; phosphatidate phosphatase LPIN2 [KO:K15728] [EC:3.1.3.4]
100585975  LPIN3; phosphatidate phosphatase LPIN3 isoform X1 [KO:K15728] [EC:3.1.3.4]
100586976  LPIN1; phosphatidate phosphatase LPIN1 isoform X6 [KO:K15728] [EC:3.1.3.4]
100605499  SIRT1; NAD-dependent protein deacetylase sirtuin-1 isoform X1 [KO:K11411] [EC:2.3.1.286]
100591812  TRA2B; transformer-2 protein homolog beta isoform X1 [KO:K12897]
100603557  TRA2A; transformer-2 protein homolog alpha isoform X1 [KO:K12897]
100599297  ADIPOQ; adiponectin [KO:K07296]
100598273  ADIPOR2; adiponectin receptor protein 2 isoform X1 [KO:K07297]
100596078  ADIPOR1; adiponectin receptor protein 1 [KO:K07297]
100590503  CAMKK2; calcium/calmodulin-dependent protein kinase kinase 2 isoform X1 [KO:K07359] [EC:2.7.11.17]
100582042  PRKAA2; 5'-AMP-activated protein kinase catalytic subunit alpha-2 isoform X1 [KO:K07198] [EC:2.7.11.31]
100595096  PRKAA1; 5'-AMP-activated protein kinase catalytic subunit alpha-1 isoform X1 [KO:K07198] [EC:2.7.11.31]
100600676  PRKAB1; 5'-AMP-activated protein kinase subunit beta-1 [KO:K07199]
100597131  PRKAB2; 5'-AMP-activated protein kinase subunit beta-2 [KO:K07199]
100598921  PRKAG2; 5'-AMP-activated protein kinase subunit gamma-2 isoform X3 [KO:K07200]
100607037  PRKAG1; 5'-AMP-activated protein kinase subunit gamma-1 [KO:K07200]
100606474  PRKAG3; 5'-AMP-activated protein kinase subunit gamma-3 [KO:K07200]
100594615  FOXO1; forkhead box protein O1 [KO:K07201]
100600519  FOXO3; forkhead box protein O3 [KO:K09408]
100589460  PPARGC1A; peroxisome proliferator-activated receptor gamma coactivator 1-alpha isoform X1 [KO:K07202]
100602258  PPARA; peroxisome proliferator-activated receptor alpha isoform X1 [KO:K07294]
100588984  CPT1A; carnitine O-palmitoyltransferase 1, liver isoform [KO:K08765] [EC:2.3.1.21]
100585921  ACADVL; very long-chain specific acyl-CoA dehydrogenase, mitochondrial isoform X1 [KO:K09479] [EC:1.3.8.9]
100600902  ACADM; medium-chain specific acyl-CoA dehydrogenase, mitochondrial isoform X1 [KO:K00249] [EC:1.3.8.7]
100590927  ACOX3; peroxisomal acyl-coenzyme A oxidase 3 isoform X1 [KO:K00232] [EC:1.3.3.6]
100595934  ACOX1; peroxisomal acyl-coenzyme A oxidase 1 isoform X1 [KO:K00232] [EC:1.3.3.6]
100588400  FABP1; fatty acid-binding protein, liver [KO:K08750]
100589222  ADH7; alcohol dehydrogenase class 4 mu/sigma chain isoform X2 [KO:K13951] [EC:1.1.1.1]
100590471  ADH1B; all-trans-retinol dehydrogenase [NAD(+)] ADH1B [KO:K13951] [EC:1.1.1.1]
100590137  alcohol dehydrogenase 1A [KO:K13951] [EC:1.1.1.1]
100589790  alcohol dehydrogenase 1C [KO:K13951] [EC:1.1.1.1]
100591370  ADH4; all-trans-retinol dehydrogenase [NAD(+)] ADH4 isoform X2 [KO:K13980] [EC:1.1.1.1]
100592499  ADH5; alcohol dehydrogenase class-3 [KO:K00121] [EC:1.1.1.284 1.1.1.1]
100590814  ADH6; alcohol dehydrogenase 6 [KO:K13952] [EC:1.1.1.1]
105740299  ALDH1B1; aldehyde dehydrogenase X, mitochondrial [KO:K00128] [EC:1.2.1.3]
100591071  ALDH3A2; aldehyde dehydrogenase family 3 member A2 isoform X1 [KO:K00128] [EC:1.2.1.3]
100601660  ALDH2; aldehyde dehydrogenase, mitochondrial [KO:K00128] [EC:1.2.1.3]
115834355  LOW QUALITY PROTEIN: aldehyde dehydrogenase, mitochondrial-like [KO:K00128] [EC:1.2.1.3]
115833843  LOW QUALITY PROTEIN: aldehyde dehydrogenase, mitochondrial-like [KO:K00128] [EC:1.2.1.3]
100583462  ALDH7A1; alpha-aminoadipic semialdehyde dehydrogenase [KO:K14085] [EC:1.2.1.31 1.2.1.8 1.2.1.3]
100594899  ALDH9A1; 4-trimethylaminobutyraldehyde dehydrogenase [KO:K00149] [EC:1.2.1.47 1.2.1.3]
100594173  cytochrome P450 2E1 [KO:K07415] [EC:1.14.14.-]
100606756  ACACB; acetyl-CoA carboxylase 2 isoform X1 [KO:K01946] [EC:6.4.1.2 6.3.4.14 2.1.3.15]
100590554  MLYCD; malonyl-CoA decarboxylase, mitochondrial [KO:K01578] [EC:4.1.1.9]
100591075  CPT1B; carnitine O-palmitoyltransferase 1, muscle isoform [KO:K19523] [EC:2.3.1.21]
100592693  NOX4; NADPH oxidase 4 isoform X2 [KO:K21423] [EC:1.6.3.-]
100604331  AKT3; RAC-gamma serine/threonine-protein kinase isoform X1 [KO:K04456] [EC:2.7.11.1]
100587864  AKT2; RAC-beta serine/threonine-protein kinase isoform X1 [KO:K04456] [EC:2.7.11.1]
100587109  AKT1; RAC-alpha serine/threonine-protein kinase [KO:K04456] [EC:2.7.11.1]
100606885  GSK3B; glycogen synthase kinase-3 beta isoform X1 [KO:K03083] [EC:2.7.11.26]
100583002  CTNNB1; catenin beta-1 isoform X1 [KO:K02105]
100595737  TCF7; LOW QUALITY PROTEIN: transcription factor 7 [KO:K02620]
100601518  TCF7L1; transcription factor 7-like 1 [KO:K04490]
100605701  TCF7L2; transcription factor 7-like 2 isoform X1 [KO:K04491]
100593051  LEF1; lymphoid enhancer-binding factor 1 isoform X3 [KO:K04492]
100605736  CCND1; G1/S-specific cyclin-D1 [KO:K04503]
100587332  MAP3K5; mitogen-activated protein kinase kinase kinase 5 isoform X1 [KO:K04426] [EC:2.7.11.25]
100587718  MAP2K4; dual specificity mitogen-activated protein kinase kinase 4 isoform X1 [KO:K04430] [EC:2.7.12.2]
100587140  MAP2K7; dual specificity mitogen-activated protein kinase kinase 7 isoform X1 [KO:K04431] [EC:2.7.12.2]
100581677  MAPK9; mitogen-activated protein kinase 9 isoform X1 [KO:K04440] [EC:2.7.11.24]
100605285  MAPK8; mitogen-activated protein kinase 8 isoform X1 [KO:K04440] [EC:2.7.11.24]
100602081  MAPK10; mitogen-activated protein kinase 10 isoform X2 [KO:K04440] [EC:2.7.11.24]
100588703  MAP2K3; dual specificity mitogen-activated protein kinase kinase 3 isoform X1 [KO:K04432] [EC:2.7.12.2]
100591256  MAP2K6; dual specificity mitogen-activated protein kinase kinase 6 isoform X1 [KO:K04433] [EC:2.7.12.2]
100595369  MAPK13; mitogen-activated protein kinase 13 isoform X2 [KO:K04441] [EC:2.7.11.24]
100600225  MAPK14; mitogen-activated protein kinase 14 isoform X1 [KO:K04441] [EC:2.7.11.24]
100580599  MAPK11; mitogen-activated protein kinase 11 isoform X5 [KO:K04441] [EC:2.7.11.24]
100600394  MAP3K14; mitogen-activated protein kinase kinase kinase 14 isoform X2 [KO:K04466] [EC:2.7.11.25]
Compound
C00003  NAD+
C00005  NADPH
C00006  NADP+
C00024  Acetyl-CoA
C00033  Acetate
C00040  Acyl-CoA
C00076  Calcium cation
C00083  Malonyl-CoA
C00084  Acetaldehyde
C00469  Ethanol
C22381  Reactive oxygen species
Reference
PMID:25782093
  Authors
Louvet A, Mathurin P
  Title
Alcoholic liver disease: mechanisms of injury and targeted treatment.
  Journal
Nat Rev Gastroenterol Hepatol 12:231-42 (2015)
DOI:10.1038/nrgastro.2015.35
Reference
PMID:21920463
  Authors
Gao B, Bataller R
  Title
Alcoholic liver disease: pathogenesis and new therapeutic targets.
  Journal
Gastroenterology 141:1572-85 (2011)
DOI:10.1053/j.gastro.2011.09.002
Reference
PMID:28134813
  Authors
Magdaleno F, Blajszczak CC, Nieto N
  Title
Key Events Participating in the Pathogenesis of Alcoholic Liver Disease.
  Journal
Biomolecules 7:E9 (2017)
DOI:10.3390/biom7010009
Reference
PMID:19553649
  Authors
Lucey MR, Mathurin P, Morgan TR
  Title
Alcoholic hepatitis.
  Journal
N Engl J Med 360:2758-69 (2009)
DOI:10.1056/NEJMra0805786
Reference
PMID:26919968
  Authors
Nagy LE, Ding WX, Cresci G, Saikia P, Shah VH
  Title
Linking Pathogenic Mechanisms of Alcoholic Liver Disease With Clinical Phenotypes.
  Journal
Gastroenterology 150:1756-68 (2016)
DOI:10.1053/j.gastro.2016.02.035
Reference
PMID:25009376
  Authors
Fujii H, Kawada N
  Title
Fibrogenesis in alcoholic liver disease.
  Journal
World J Gastroenterol 20:8048-54 (2014)
DOI:10.3748/wjg.v20.i25.8048
Reference
PMID:26755857
  Authors
Kim MS, Ong M, Qu X
  Title
Optimal management for alcoholic liver disease: Conventional medications, natural therapy or combination?
  Journal
World J Gastroenterol 22:8-23 (2016)
DOI:10.3748/wjg.v22.i1.8
Reference
PMID:15194557
  Authors
You M, Crabb DW
  Title
Recent advances in alcoholic liver disease II. Minireview: molecular mechanisms of alcoholic fatty liver.
  Journal
Am J Physiol Gastrointest Liver Physiol 287:G1-6 (2004)
DOI:10.1152/ajpgi.00056.2004
Reference
PMID:26695748
  Authors
Nagy LE
  Title
The Role of Innate Immunity in Alcoholic Liver Disease.
  Journal
Alcohol Res 37:237-50 (2015)
Reference
PMID:21252049
  Authors
Gao B, Seki E, Brenner DA, Friedman S, Cohen JI, Nagy L, Szabo G, Zakhari S
  Title
Innate immunity in alcoholic liver disease.
  Journal
Am J Physiol Gastrointest Liver Physiol 300:G516-25 (2011)
DOI:10.1152/ajpgi.00537.2010
Reference
PMID:22524187
  Authors
Wang HJ, Gao B, Zakhari S, Nagy LE
  Title
Inflammation in alcoholic liver disease.
  Journal
Annu Rev Nutr 32:343-68 (2012)
DOI:10.1146/annurev-nutr-072610-145138
Reference
PMID:29597356
  Authors
McCullough RL, McMullen MR, Sheehan MM, Poulsen KL, Roychowdhury S, Chiang DJ, Pritchard MT, Caballeria J, Nagy LE
  Title
Complement Factor D protects mice from ethanol-induced inflammation and liver injury.
  Journal
Am J Physiol Gastrointest Liver Physiol 315:G66-G79 (2018)
DOI:10.1152/ajpgi.00334.2017
Reference
PMID:24385684
  Authors
Kawaratani H, Tsujimoto T, Douhara A, Takaya H, Moriya K, Namisaki T, Noguchi R, Yoshiji H, Fujimoto M, Fukui H
  Title
The effect of inflammatory cytokines in alcoholic liver disease.
  Journal
Mediators Inflamm 2013:495156 (2013)
DOI:10.1155/2013/495156
Reference
PMID:20238398
  Authors
Szabo G, Bala S
  Title
Alcoholic liver disease and the gut-liver axis.
  Journal
World J Gastroenterol 16:1321-9 (2010)
DOI:10.3748/wjg.v16.i11.1321
Reference
PMID:28627645
  Authors
Kawaratani H, Moriya K, Namisaki T, Uejima M, Kitade M, Takeda K, Okura Y, Kaji K, Takaya H, Nishimura N, Sato S, Sawada Y, Seki K, Kubo T, Mitoro A, Yamao J, Yoshiji H
  Title
Therapeutic strategies for alcoholic liver disease: Focusing on inflammation and fibrosis (Review).
  Journal
Int J Mol Med 40:263-270 (2017)
DOI:10.3892/ijmm.2017.3015
Reference
PMID:23855294
  Authors
Roh YS, Seki E
  Title
Toll-like receptors in alcoholic liver disease, non-alcoholic steatohepatitis and carcinogenesis.
  Journal
J Gastroenterol Hepatol 28 Suppl 1:38-42 (2013)
DOI:10.1111/jgh.12019
Reference
PMID:18709650
  Authors
Rogers CQ, Ajmo JM, You M
  Title
Adiponectin and alcoholic fatty liver disease.
  Journal
IUBMB Life 60:790-7 (2008)
DOI:10.1002/iub.124
Reference
PMID:26278388
  Authors
You M, Jogasuria A, Lee K, Wu J, Zhang Y, Lee YK, Sadana P
  Title
Signal Transduction Mechanisms of Alcoholic Fatty Liver Disease: Emer ging Role of Lipin-1.
  Journal
Curr Mol Pharmacol 10:226-236 (2017)
DOI:10.2174/1874467208666150817112109
Reference
PMID:26005675
  Authors
You M, Jogasuria A, Taylor C, Wu J
  Title
Sirtuin 1 signaling and alcoholic fatty liver disease.
  Journal
Hepatobiliary Surg Nutr 4:88-100 (2015)
DOI:10.3978/j.issn.2304-3881.2014.12.06
Reference
PMID:33162823
  Authors
Ren R, Wang Z, Wu M, Wang H
  Title
Emerging Roles of SIRT1 in Alcoholic Liver Disease.
  Journal
Int J Biol Sci 16:3174-3183 (2020)
DOI:10.7150/ijbs.49535
Reference
PMID:19032584
  Authors
Purohit V, Gao B, Song BJ
  Title
Molecular mechanisms of alcoholic fatty liver.
  Journal
Alcohol Clin Exp Res 33:191-205 (2009)
DOI:10.1111/j.1530-0277.2008.00827.x
Reference
PMID:34071962
  Authors
Hyun J, Han J, Lee C, Yoon M, Jung Y
  Title
Pathophysiological Aspects of Alcohol Metabolism in the Liver.
  Journal
Int J Mol Sci 22:5717 (2021)
DOI:10.3390/ijms22115717
Reference
PMID:24297186
  Authors
Combs TP, Marliss EB
  Title
Adiponectin signaling in the liver.
  Journal
Rev Endocr Metab Disord 15:137-47 (2014)
DOI:10.1007/s11154-013-9280-6
Reference
PMID:25548474
  Authors
Ceni E, Mello T, Galli A
  Title
Pathogenesis of alcoholic liver disease: role of oxidative metabolism.
  Journal
World J Gastroenterol 20:17756-72 (2014)
DOI:10.3748/wjg.v20.i47.17756
Reference
PMID:31159489
  Authors
Kong LZ, Chandimali N, Han YH, Lee DH, Kim JS, Kim SU, Kim TD, Jeong DK, Sun HN, Lee DS, Kwon T
  Title
Pathogenesis, Early Diagnosis, and Therapeutic Management of Alcoholic Liver Disease.
  Journal
Int J Mol Sci 20:E2712 (2019)
DOI:10.3390/ijms20112712
Reference
PMID:31214376
  Authors
Ohashi K, Pimienta M, Seki E
  Title
Alcoholic liver disease: A current molecular and clinical perspective.
  Journal
Liver Res 2:161-172 (2018)
DOI:10.1016/j.livres.2018.11.002
Reference
PMID:30658725
  Authors
You M, Arteel GE
  Title
Effect of ethanol on lipid metabolism.
  Journal
J Hepatol 70:237-248 (2019)
DOI:10.1016/j.jhep.2018.10.037
Reference
PMID:25595739
  Authors
Bi L, Jiang Z, Zhou J
  Title
The role of lipin-1 in the pathogenesis of alcoholic fatty liver.
  Journal
Alcohol Alcohol 50:146-51 (2015)
DOI:10.1093/alcalc/agu102
Reference
PMID:31263795
  Authors
Ali H, Assiri MA, Shearn CT, Fritz KS
  Title
Lipid peroxidation derived reactive aldehydes in alcoholic liver disease.
  Journal
Curr Opin Toxicol 13:110-117 (2019)
DOI:10.1016/j.cotox.2018.10.003
Reference
PMID:24262277
  Authors
Yin H, Hu M, Liang X, Ajmo JM, Li X, Bataller R, Odena G, Stevens SM Jr, You M
  Title
Deletion of SIRT1 from hepatocytes in mice disrupts lipin-1 signaling and aggravates alcoholic fatty liver.
  Journal
Gastroenterology 146:801-11 (2014)
DOI:10.1053/j.gastro.2013.11.008
Reference
PMID:22110053
  Authors
Stickel F, Hampe J
  Title
Genetic determinants of alcoholic liver disease.
  Journal
Gut 61:150-9 (2012)
DOI:10.1136/gutjnl-2011-301239
Reference
PMID:29336467
  Authors
Yang CF, Zhong YJ, Ma Z, Li L, Shi L, Chen L, Li C, Wu D, Chen Q, Li YW
  Title
NOX4/ROS mediate ethanolinduced apoptosis via MAPK signal pathway in L02 cells.
  Journal
Int J Mol Med 41:2306-2316 (2018)
DOI:10.3892/ijmm.2018.3390
Related
pathway
nle00061  Fatty acid biosynthesis
nle00071  Fatty acid degradation
nle01040  Biosynthesis of unsaturated fatty acids
nle03040  Spliceosome
nle04010  MAPK signaling pathway
nle04064  NF-kappa B signaling pathway
nle04152  AMPK signaling pathway
nle04210  Apoptosis
nle04310  Wnt signaling pathway
nle04610  Complement and coagulation cascades
nle04620  Toll-like receptor signaling pathway
nle04657  IL-17 signaling pathway
nle04668  TNF signaling pathway
nle04920  Adipocytokine signaling pathway
nle05034  Alcoholism
nle05225  Hepatocellular carcinoma
KO pathway
ko04936   
LinkDB

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