KEGG   PATHWAY: npo05207
Entry
npo05207                    Pathway                                
Name
Chemical carcinogenesis - receptor activation - Nyctereutes procyonoides (raccoon dog)
Description
Carcinogenesis is a multistage process that consists of initiation, promotion, and progression stages. Chemicals or environmental factors may act at any of these stages to induce and/or enhance the carcinogenic process. Based on their mode-of-action, carcinogens can be classified as genotoxic or non-genotoxic. Genotoxic agent begins their action at the deoxyribonucleic acid (DNA) level, causing DNA damage through several mechanisms. Non-genotoxic carcinogens are chemicals that cause the development of tumors through multiple non-genotoxic events and epigenetic alterations without direct interaction with DNA. One non-genotoxic mechanism involves receptor activation. Biological mechanisms involving receptor activation fall into two broad categories: (i) those that involve cell surface receptors and some intracellular receptors that activate signal transduction pathways, resulting in biological responses, including gene transcription, and (ii) those that involve intracellular receptors that translocate into the nucleus and act as transcription factors regulating gene expression. Both classes of receptors can be involved in mechanisms of carcinogenesis.
Class
Human Diseases; Cancer: overview
Pathway map
npo05207  Chemical carcinogenesis - receptor activation
npo05207

Organism
Nyctereutes procyonoides (raccoon dog) [GN:npo]
Gene
129510377  neuronal acetylcholine receptor subunit alpha-7 isoform X1 [KO:K04809]
129497145  ARRB2; beta-arrestin-2 isoform X1 [KO:K04439]
129506668  ARRB1; beta-arrestin-1 isoform X1 [KO:K04439]
129494438  SRC; proto-oncogene tyrosine-protein kinase Src [KO:K05704] [EC:2.7.10.2]
129522592  RAF1; RAF proto-oncogene serine/threonine-protein kinase isoform X1 [KO:K04366] [EC:2.7.11.1]
129516428  RB1; retinoblastoma-associated protein isoform X1 [KO:K06618]
129496621  E2F1; transcription factor E2F1 [KO:K17454]
129517703  XIAP; E3 ubiquitin-protein ligase XIAP [KO:K04725] [EC:2.3.2.27]
129504209  CDC6; cell division control protein 6 homolog [KO:K02213]
129522597  CDC25A; M-phase inducer phosphatase 1 isoform X1 [KO:K06645] [EC:3.1.3.48]
129499911  JAK2; tyrosine-protein kinase JAK2 [KO:K04447] [EC:2.7.10.2]
129506479  STAT3; signal transducer and activator of transcription 3 isoform X1 [KO:K04692]
129515179  IKBKE; inhibitor of nuclear factor kappa-B kinase subunit epsilon isoform X1 [KO:K07211] [EC:2.7.11.10]
129502968  CCND1; G1/S-specific cyclin-D1 [KO:K04503]
129496290  CHRNA4; neuronal acetylcholine receptor subunit alpha-4 [KO:K04806]
129509121  CHRNB2; neuronal acetylcholine receptor subunit beta-2 [KO:K04813]
129520705  CHRNA3; neuronal acetylcholine receptor subunit alpha-3 [KO:K04805]
129520248  CHRNB4; neuronal acetylcholine receptor subunit beta-4 [KO:K04815]
129503382  CACNA1C; LOW QUALITY PROTEIN: voltage-dependent L-type calcium channel subunit alpha-1C [KO:K04850]
129521343  CACNA1D; voltage-dependent L-type calcium channel subunit alpha-1D [KO:K04851]
129517804  CACNA1F; voltage-dependent L-type calcium channel subunit alpha-1F isoform X1 [KO:K04853]
129505985  CACNA1S; voltage-dependent L-type calcium channel subunit alpha-1S [KO:K04857]
129515558  CACNA1B; voltage-dependent N-type calcium channel subunit alpha-1B [KO:K04849]
129522364  CACNA1A; voltage-dependent P/Q-type calcium channel subunit alpha-1A isoform X1 [KO:K04344]
129496789  PIK3CD; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform isoform X1 [KO:K00922] [EC:2.7.1.153]
129498637  PIK3CA; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform [KO:K00922] [EC:2.7.1.153]
129507069  PIK3CB; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform [KO:K00922] [EC:2.7.1.153]
129513452  PIK3R1; phosphatidylinositol 3-kinase regulatory subunit alpha isoform X1 [KO:K02649]
129520803  PIK3R3; phosphatidylinositol 3-kinase regulatory subunit gamma isoform X1 [KO:K02649]
129522073  PIK3R2; phosphatidylinositol 3-kinase regulatory subunit beta [KO:K02649]
129508823  AKT3; RAC-gamma serine/threonine-protein kinase [KO:K04456] [EC:2.7.11.1]
129495892  AKT1; RAC-alpha serine/threonine-protein kinase [KO:K04456] [EC:2.7.11.1]
129499851  AKT2; RAC-beta serine/threonine-protein kinase isoform X1 [KO:K04456] [EC:2.7.11.1]
129517633  RAC-alpha serine/threonine-protein kinase-like [KO:K04456] [EC:2.7.11.1]
129514778  RAC-alpha serine/threonine-protein kinase-like [KO:K04456] [EC:2.7.11.1]
129513263  MTOR; serine/threonine-protein kinase mTOR [KO:K07203] [EC:2.7.11.1]
129521190  NFKB1; nuclear factor NF-kappa-B p105 subunit isoform X1 [KO:K02580]
129503049  RELA; transcription factor p65 isoform X1 [KO:K04735]
129494224  HRAS; GTPase HRas isoform X1 [KO:K02833]
129505561  KRAS; GTPase KRas isoform X1 [KO:K07827]
129501466  NRAS; GTPase NRas [KO:K07828]
129506345  MAP2K1; dual specificity mitogen-activated protein kinase kinase 1 [KO:K04368] [EC:2.7.12.2]
129522322  MAP2K2; dual specificity mitogen-activated protein kinase kinase 2 [KO:K04369] [EC:2.7.12.2]
129502349  mitogen-activated protein kinase 3-like [KO:K04371] [EC:2.7.11.24]
129507918  MAPK1; mitogen-activated protein kinase 1 [KO:K04371] [EC:2.7.11.24]
129519082  MAPK3; mitogen-activated protein kinase 3 [KO:K04371] [EC:2.7.11.24]
129496401  FOS; protein c-Fos [KO:K04379]
129497811  JUN; transcription factor Jun [KO:K04448]
129502657  MYC; myc proto-oncogene protein [KO:K04377]
129495480  apoptosis regulator Bcl-2 isoform X1 [KO:K02161]
129514527  apoptosis regulator Bcl-2 isoform X1 [KO:K02161]
129494612  PRKCA; protein kinase C alpha type [KO:K02677] [EC:2.7.11.13]
129519978  PRKCB; protein kinase C beta type isoform X1 [KO:K19662] [EC:2.7.11.13]
129500385  PRKCG; protein kinase C gamma type [KO:K19663] [EC:2.7.11.13]
129512852  VEGFA; vascular endothelial growth factor A [KO:K05448]
129504328  FGF2; fibroblast growth factor 2 [KO:K18497]
129523256  ADRB1; LOW QUALITY PROTEIN: beta-1 adrenergic receptor [KO:K04141]
129509323  ADRB2; beta-2 adrenergic receptor [KO:K04142]
129516073  ADRB3; beta-3 adrenergic receptor [KO:K04143]
129497792  GNAS; guanine nucleotide-binding protein G(s) subunit alpha isoforms XLas isoform X1 [KO:K04632]
129497848  neuroendocrine secretory protein 55 [KO:K04632]
129512833  guanine nucleotide-binding protein G(s) subunit alpha-like isoform X1 [KO:K04632]
129515724  LOW QUALITY PROTEIN: adenylate cyclase type 1-like [KO:K08041] [EC:4.6.1.1]
129516202  adenylate cyclase type 1 [KO:K08041] [EC:4.6.1.1]
129498939  ADCY2; adenylate cyclase type 2 [KO:K08042] [EC:4.6.1.1]
129510932  ADCY3; adenylate cyclase type 3 [KO:K08043] [EC:4.6.1.1]
129499511  ADCY4; adenylate cyclase type 4 isoform X1 [KO:K08044] [EC:4.6.1.1]
129503910  ADCY5; adenylate cyclase type 5 [KO:K08045] [EC:4.6.1.1]
129517234  ADCY6; adenylate cyclase type 6 isoform X1 [KO:K08046] [EC:4.6.1.1]
129513386  ADCY7; adenylate cyclase type 7 isoform X1 [KO:K08047] [EC:4.6.1.1]
129502672  ADCY8; adenylate cyclase type 8 [KO:K08048] [EC:4.6.1.1]
129519450  ADCY9; adenylate cyclase type 9 [KO:K08049] [EC:4.6.1.1]
129519960  PRKACB; cAMP-dependent protein kinase catalytic subunit beta isoform X1 [KO:K04345] [EC:2.7.11.11]
129521768  PRKACA; cAMP-dependent protein kinase catalytic subunit alpha isoform X1 [KO:K04345] [EC:2.7.11.11]
129522997  CREB1; cyclic AMP-responsive element-binding protein 1 isoform X1 [KO:K05870]
129518269  cyclic AMP-responsive element-binding protein 1-like [KO:K05870]
129498595  ATF2; cyclic AMP-dependent transcription factor ATF-2 isoform X1 [KO:K04450]
129511576  ATF4; cyclic AMP-dependent transcription factor ATF-4 [KO:K04374]
129508719  CREB3L4; cyclic AMP-responsive element-binding protein 3-like protein 4 isoform X1 [KO:K09048]
129494799  CREB3; cyclic AMP-responsive element-binding protein 3 isoform X1 [KO:K09048]
129503105  CREB3L1; cyclic AMP-responsive element-binding protein 3-like protein 1 [KO:K09048]
129515926  CREB3L2; cyclic AMP-responsive element-binding protein 3-like protein 2 [KO:K09048]
129522278  CREB3L3; cyclic AMP-responsive element-binding protein 3-like protein 3 [KO:K09048]
129502771  CREB5; cyclic AMP-responsive element-binding protein 5 isoform X1 [KO:K09047]
129513003  ATF6B; cyclic AMP-dependent transcription factor ATF-6 beta isoform X1 [KO:K09049]
129494269  GNAI1; guanine nucleotide-binding protein G(i) subunit alpha-1 [KO:K04630]
129519569  GNAI3; guanine nucleotide-binding protein G(i) subunit alpha-3 [KO:K04630]
129522106  GNAI2; guanine nucleotide-binding protein G(i) subunit alpha-2 [KO:K04630]
129503119  BAD; bcl2-associated agonist of cell death [KO:K02158]
129510428  CHRNA9; neuronal acetylcholine receptor subunit alpha-9 [KO:K04810]
129500413  RPS6KA2; ribosomal protein S6 kinase alpha-2 isoform X1 [KO:K04373] [EC:2.7.11.1]
129517499  RPS6KA6; ribosomal protein S6 kinase alpha-6 [KO:K04373] [EC:2.7.11.1]
129518199  RPS6KA3; ribosomal protein S6 kinase alpha-3 isoform X1 [KO:K04373] [EC:2.7.11.1]
129513891  RPS6KA1; ribosomal protein S6 kinase alpha-1 isoform X1 [KO:K04373] [EC:2.7.11.1]
129500554  ESR1; estrogen receptor [KO:K08550]
129496007  ESR2; estrogen receptor beta [KO:K08551]
129505676  VDR; vitamin D3 receptor [KO:K08539]
129512587  CCND3; G1/S-specific cyclin-D3 isoform X1 [KO:K10152]
129494118  EGFR; epidermal growth factor receptor isoform X1 [KO:K04361] [EC:2.7.10.1]
129511906  GRB2; growth factor receptor-bound protein 2 [KO:K04364]
129496132  SOS2; son of sevenless homolog 2 [KO:K03099]
129510881  SOS1; son of sevenless homolog 1 isoform X1 [KO:K03099]
129515882  EIF4EBP1; eukaryotic translation initiation factor 4E-binding protein 1 [KO:K07205]
129501834  RPS6KB2; ribosomal protein S6 kinase beta-2 isoform X1 [KO:K04688] [EC:2.7.11.1]
129510988  RPS6KB1; ribosomal protein S6 kinase beta-1 isoform X1 [KO:K04688] [EC:2.7.11.1]
129514257  PAQR7; membrane progestin receptor alpha [KO:K25039]
129512338  PAQR8; membrane progestin receptor beta isoform X1 [KO:K25040]
129506234  PAQR5; membrane progestin receptor gamma [KO:K25041]
129506795  PGR; progesterone receptor isoform X1 [KO:K08556]
129516607  TNFSF11; tumor necrosis factor ligand superfamily member 11 [KO:K05473]
129513286  STAT5A; signal transducer and activator of transcription 5A [KO:K11223]
129508314  signal transducer and activator of transcription 5B isoform X1 [KO:K11224]
129498393  BCL6; B-cell lymphoma 6 protein [KO:K15618]
129516531  KLF5; Krueppel-like factor 5 [KO:K09206]
129495255  KLF4; Krueppel-like factor 4 [KO:K17846]
129517408  WNT1; proto-oncogene Wnt-1 [KO:K03209]
129501384  NOTCH2; neurogenic locus notch homolog protein 2 isoform X1 [KO:K20994]
129523312  JAG1; protein jagged-1 [KO:K06052]
129517777  AR; androgen receptor [KO:K08557]
129521218  EGF; pro-epidermal growth factor isoform X1 [KO:K04357]
129501850  FGF5; fibroblast growth factor 5 isoform X1 [KO:K04358]
129509339  FGF10; fibroblast growth factor 10 [KO:K04358]
129493821  FGF8; fibroblast growth factor 8 isoform X1 [KO:K04358]
129493891  FGF17; fibroblast growth factor 17 isoform X1 [KO:K04358]
129503172  FGF3; fibroblast growth factor 3 [KO:K04358]
129503472  FGF6; fibroblast growth factor 6 isoform X1 [KO:K04358]
129504579  FGF9; fibroblast growth factor 9 [KO:K04358]
129499133  FGF4; LOW QUALITY PROTEIN: fibroblast growth factor 4 [KO:K04358]
129506303  FGF7; fibroblast growth factor 7 isoform X1 [KO:K04358]
129516186  FGF20; fibroblast growth factor 20 [KO:K04358]
129509565  FGF18; fibroblast growth factor 18 [KO:K04358]
129518363  FGF16; fibroblast growth factor 16 [KO:K04358]
129521996  FGF22; fibroblast growth factor 22 isoform X1 [KO:K04358]
129500787  DLL3; delta-like protein 3 [KO:K06051]
129504277  DLL4; delta-like protein 4 [KO:K06051]
129513134  DLL1; delta-like protein 1 [KO:K06051]
129511559  PTGES3; prostaglandin E synthase 3 [KO:K15730] [EC:5.3.99.3]
129503038  AIP; AH receptor-interacting protein isoform X1 [KO:K17767]
129497750  AIPL1; aryl-hydrocarbon-interacting protein-like 1 [KO:K17767]
129502884  AHR; aryl hydrocarbon receptor [KO:K09093]
129494639  LOW QUALITY PROTEIN: heat shock protein HSP 90-beta-like [KO:K04079]
129496348  HSP90AA1; heat shock protein HSP 90-alpha [KO:K04079]
129513069  HSP90AB1; heat shock protein HSP 90-beta [KO:K04079]
129516837  HSP90B1; endoplasmin [KO:K09487]
129503695  KPNA1; importin subunit alpha-5 [KO:K23940]
129504333  importin subunit alpha-8-like [KO:K15043]
129517561  KPNA2; importin subunit alpha-1 [KO:K15043]
129517911  LOW QUALITY PROTEIN: importin subunit alpha-1-like [KO:K15043]
129519882  KPNA7; importin subunit alpha-8 [KO:K15043]
129498647  KPNA4; importin subunit alpha-3 [KO:K23583]
129516606  KPNA3; importin subunit alpha-4 [KO:K23583]
129500540  KPNA5; importin subunit alpha-6 isoform X1 [KO:K15042]
129513832  KPNA6; importin subunit alpha-7 [KO:K15042]
129510336  KPNB1; importin subunit beta-1 [KO:K14293]
129501302  ARNT; aryl hydrocarbon receptor nuclear translocator [KO:K09097]
129506483  cytochrome P450 1A1 [KO:K07408] [EC:1.14.14.1]
129511133  cytochrome P450 1B1 [KO:K07410] [EC:1.14.14.1]
129508629  EPHX1; epoxide hydrolase 1 isoform X1 [KO:K01253] [EC:3.3.2.9]
129523302  EPHX2; LOW QUALITY PROTEIN: bifunctional epoxide hydrolase 2 [KO:K08726] [EC:3.3.2.10 3.1.3.76]
129521794  EPHX3; epoxide hydrolase 3 [KO:K22368] [EC:3.3.2.10]
129519933  EPHX4; epoxide hydrolase 4 [KO:K22369] [EC:3.3.-.-]
129508063  glutathione S-transferase theta-1-like [KO:K00799] [EC:2.5.1.18]
129508064  glutathione S-transferase theta-4 [KO:K00799] [EC:2.5.1.18]
129508065  LOW QUALITY PROTEIN: glutathione S-transferase theta-1-like [KO:K00799] [EC:2.5.1.18]
129508066  glutathione S-transferase theta-3-like [KO:K00799] [EC:2.5.1.18]
129503888  glutathione S-transferase A4-like [KO:K00799] [EC:2.5.1.18]
129504376  MGST2; microsomal glutathione S-transferase 2 isoform X1 [KO:K00799] [EC:2.5.1.18]
129505666  MGST1; microsomal glutathione S-transferase 1 [KO:K00799] [EC:2.5.1.18]
129507715  glutathione S-transferase theta-2B-like [KO:K00799] [EC:2.5.1.18]
129515365  MGST3; microsomal glutathione S-transferase 3 [KO:K00799] [EC:2.5.1.18]
129523112  GSTO2; glutathione S-transferase omega-2 [KO:K00799] [EC:2.5.1.18]
129523231  GSTO1; glutathione S-transferase omega-1 [KO:K00799] [EC:2.5.1.18]
129517785  glutathione S-transferase A4-like [KO:K00799] [EC:2.5.1.18]
129519079  GSTM3; glutathione S-transferase Mu 3 isoform X1 [KO:K00799] [EC:2.5.1.18]
129512342  glutathione S-transferase A3 [KO:K00799] [EC:2.5.1.18]
129512343  glutathione S-transferase A4-like [KO:K00799] [EC:2.5.1.18]
129512344  glutathione S-transferase A4 isoform X1 [KO:K00799] [EC:2.5.1.18]
129520272  glutathione S-transferase Mu 1 [KO:K00799] [EC:2.5.1.18]
129513051  glutathione S-transferase-like [KO:K00799] [EC:2.5.1.18]
129520772  microsomal glutathione S-transferase 3-like [KO:K00799] [EC:2.5.1.18]
129493696  LOW QUALITY PROTEIN: UDP-glucuronosyltransferase 1A1-like [KO:K00699] [EC:2.4.1.17]
129493697  LOW QUALITY PROTEIN: UDP-glucuronosyltransferase 1A8-like [KO:K00699] [EC:2.4.1.17]
129493754  UDP-glucuronosyltransferase 1A9-like [KO:K00699] [EC:2.4.1.17]
129503300  UDP-glucuronosyltransferase 2A2 isoform X1 [KO:K00699] [EC:2.4.1.17]
129503302  UDP-glucuronosyltransferase 2B31-like isoform X1 [KO:K00699] [EC:2.4.1.17]
129503303  UDP-glucuronosyltransferase 2A3-like [KO:K00699] [EC:2.4.1.17]
129506279  UDP-glucuronosyltransferase 2B31-like [KO:K00699] [EC:2.4.1.17]
129506322  UDP-glucuronosyltransferase 2B31-like [KO:K00699] [EC:2.4.1.17]
129523177  UDP-glucuronosyltransferase 1A3-like [KO:K00699] [EC:2.4.1.17]
129523178  UDP-glucuronosyltransferase 1A3-like [KO:K00699] [EC:2.4.1.17]
129523179  LOW QUALITY PROTEIN: UDP-glucuronosyltransferase 1A8-like [KO:K00699] [EC:2.4.1.17]
129523180  LOW QUALITY PROTEIN: UDP-glucuronosyltransferase 1A8-like [KO:K00699] [EC:2.4.1.17]
129516185  LOW QUALITY PROTEIN: UDP-glucuronosyltransferase 1A3-like [KO:K00699] [EC:2.4.1.17]
129521338  UDP-glucuronosyltransferase 2B31 [KO:K00699] [EC:2.4.1.17]
129499612  cytochrome P450 2B11 [KO:K07412] [EC:1.14.14.1]
129515399  NR1I3; nuclear receptor subfamily 1 group I member 3 isoform X1 [KO:K08541]
129510105  RXRA; retinoic acid receptor RXR-alpha isoform X1 [KO:K08524]
129512540  RXRB; retinoic acid receptor RXR-beta isoform X1 [KO:K08525]
129515284  RXRG; retinoic acid receptor RXR-gamma isoform X1 [KO:K08526]
129519424  cytochrome P450 3A12-like isoform X1 [KO:K07424] [EC:1.14.14.1]
129519425  cytochrome P450 3A12-like [KO:K07424] [EC:1.14.14.1]
129519426  cytochrome P450 3A12-like isoform X1 [KO:K07424] [EC:1.14.14.1]
129519435  cytochrome P450 3A12 [KO:K07424] [EC:1.14.14.1]
129506143  cytochrome P450 1A2 isoform X1 [KO:K07409] [EC:1.14.14.1]
129511914  PPARA; peroxisome proliferator-activated receptor alpha [KO:K07294]
Compound
C00076  Calcium cation
C00410  Progesterone
C00547  L-Noradrenaline
C00575  3',5'-Cyclic AMP
C00745  Nicotine
C00780  Serotonin
C00788  L-Adrenaline
C00951  Estradiol-17beta
C03690  Bis(2-ethylhexyl)phthalate
C04623  DDT
C05981  Phosphatidylinositol-3,4,5-trisphosphate
C06697  Arsenite
C06790  Trichloroethene
C06916  Clofibrate
C07020  Gemfibrozil
C07434  Phenobarbital
C07535  Benzo[a]pyrene
C07557  2,3,7,8-Tetrachlorodibenzodioxin
C08150  Medroxyprogesterone acetate
C11042  Hexachlorobenzene
C11150  Trichloroacetate
C11371  Nafenopin
C11906  Sodium arsenite
C13624  Bisphenol A
C14240  Di(2-ethylhexyl) adipate
C14573  3,3',4,4',5-Pentachlorobiphenyl
C15995  Bombesin
C16452  N'-Nitrosonornicotine
C16453  4-(N-Nitrosomethylamino)-1-(3-pyridyl)-1-butanone
Reference
PMID:15660110
  Authors
Luch A.
  Title
Nature and nurture - lessons from chemical carcinogenesis.
  Journal
Nat Rev Cancer 5:113-25 (2005)
DOI:10.1038/nrc1546
Reference
PMID:19631282
  Authors
Hernandez LG, van Steeg H, Luijten M, van Benthem J
  Title
Mechanisms of non-genotoxic carcinogens and importance of a weight of evidence approach.
  Journal
Mutat Res 682:94-109 (2009)
DOI:10.1016/j.mrrev.2009.07.002
Reference
PMID:21444681
  Authors
Wu CH, Lee CH, Ho YS
  Title
Nicotinic acetylcholine receptor-based blockade: applications of molecular targets for cancer therapy.
  Journal
Clin Cancer Res 17:3533-41 (2011)
DOI:10.1158/1078-0432.CCR-10-2434
Reference
PMID:19194381
  Authors
Schuller HM
  Title
Is cancer triggered by altered signalling of nicotinic acetylcholine receptors?
  Journal
Nat Rev Cancer 9:195-205 (2009)
DOI:10.1038/nrc2590
Reference
PMID:21541211
  Authors
Singh S, Pillai S, Chellappan S
  Title
Nicotinic acetylcholine receptor signaling in tumor growth and metastasis.
  Journal
J Oncol 2011:456743 (2011)
DOI:10.1155/2011/456743
Reference
PMID:31956359
  Authors
Cheng WL, Chen KY, Lee KY, Feng PH, Wu SM
  Title
Nicotinic-nAChR signaling mediates drug resistance in lung cancer.
  Journal
J Cancer 11:1125-1140 (2020)
DOI:10.7150/jca.36359
Reference
PMID:24827506
  Authors
Grando SA
  Title
Connections of nicotine to cancer.
  Journal
Nat Rev Cancer 14:419-29 (2014)
DOI:10.1038/nrc3725
Reference
PMID:24398389
  Authors
Schaal C, Chellappan SP
  Title
Nicotine-mediated cell proliferation and tumor progression in smoking-related cancers.
  Journal
Mol Cancer Res 12:14-23 (2014)
DOI:10.1158/1541-7786.MCR-13-0541
Reference
PMID:21640716
  Authors
Improgo MR, Tapper AR, Gardner PD
  Title
Nicotinic acetylcholine receptor-mediated mechanisms in lung cancer.
  Journal
Biochem Pharmacol 82:1015-21 (2011)
DOI:10.1016/j.bcp.2011.05.020
Reference
PMID:18262664
  Authors
Egleton RD, Brown KC, Dasgupta P
  Title
Nicotinic acetylcholine receptors in cancer: multiple roles in proliferation and inhibition of apoptosis.
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Related
pathway
npo00980  Metabolism of xenobiotics by cytochrome P450
npo03320  PPAR signaling pathway
npo04010  MAPK signaling pathway
npo04024  cAMP signaling pathway
npo04150  mTOR signaling pathway
npo04151  PI3K-Akt signaling pathway
npo04370  VEGF signaling pathway
npo04915  Estrogen signaling pathway
npo05204  Chemical carcinogenesis - DNA adducts
npo05206  MicroRNAs in cancer
npo05208  Chemical carcinogenesis - reactive oxygen species
KO pathway
ko05207   
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