KEGG   PATHWAY: npr04020
Entry
npr04020                    Pathway                                
Name
Calcium signaling pathway - Nanorana parkeri (Xizang Plateau frog)
Description
Ca2+ that enters the cell from the outside is a principal source of signal Ca2+. Entry of Ca2+ is driven by the presence of a large electrochemical gradient across the plasma membrane. Cells use this external source of signal Ca2+ by activating various entry channels with widely different properties. The voltage-operated channels (VOCs) are found in excitable cells and generate the rapid Ca2+ fluxes that control fast cellular processes. There are many other Ca2+-entry channels, such as the receptor-operated channels (ROCs), for example the NMDA (N-methyl-D-aspartate) receptors (NMDARs) that respond to glutamate. There also are second-messenger-operated channels (SMOCs) and store-operated channels (SOCs).
The other principal source of Ca2+ for signalling is the internal stores that are located primarily in the endoplasmic/sarcoplasmic reticulum (ER/SR), in which inositol-1,4,5-trisphosphate receptors (IP3Rs) or ryanodine receptors (RYRs) regulate the release of Ca2+. The principal activator of these channels is Ca2+ itself and this process of Ca2+-induced Ca2+ release is central to the mechanism of Ca2+ signalling. Various second messengers or modulators also control the release of Ca2+. IP3, which is generated by pathways using different isoforms of phospholipase C (PLCbeta, delta, epsilon, gamma and zeta), regulates the IP3Rs. Cyclic ADP-ribose (cADPR) releases Ca2+ via RYRs. Nicotinic acid adenine dinucleotide phosphate (NAADP) may activate a distinct Ca2+ release mechanism on separate acidic Ca2+ stores. Ca2+ release via the NAADP-sensitive mechanism may also feedback onto either RYRs or IP3Rs. cADPR and NAADP are generated by CD38. This enzyme might be sensitive to the cellular metabolism, as ATP and NADH inhibit it.
The influx of Ca2+ from the environment or release from internal stores causes a very rapid and dramatic increase in cytoplasmic calcium concentration, which has been widely exploited for signal transduction. Some proteins, such as troponin C (TnC) involved in muscle contraction, directly bind to and sense Ca2+. However, in other cases Ca2+ is sensed through intermediate calcium sensors such as calmodulin (CALM).
Class
Environmental Information Processing; Signal transduction
Pathway map
npr04020  Calcium signaling pathway
npr04020

Other DBs
GO: 0019722
Organism
Nanorana parkeri (Xizang Plateau frog) [GN:npr]
Gene
108786669  SLC8A2; sodium/calcium exchanger 2 isoform X1 [KO:K05849]
108788925  SLC8A1; sodium/calcium exchanger 1 isoform X1 [KO:K05849]
108794054  sodium/calcium exchanger 1-like [KO:K05849]
108787233  ATP2B1; plasma membrane calcium-transporting ATPase 1 isoform X1 [KO:K05850] [EC:7.2.2.10]
108804864  plasma membrane calcium-transporting ATPase 2-like [KO:K05850] [EC:7.2.2.10]
108798381  ATP2B3; plasma membrane calcium-transporting ATPase 3 isoform X1 [KO:K05850] [EC:7.2.2.10]
108785248  CHRM1; muscarinic acetylcholine receptor M1 [KO:K04129]
108785168  CHRM5; muscarinic acetylcholine receptor M5 [KO:K04133]
108787795  ADORA2A; adenosine receptor A2a isoform X1 [KO:K04266]
108790722  ADORA2B; adenosine receptor A2b [KO:K04267]
108802079  ADRB1; beta-1 adrenergic receptor [KO:K04141]
108803519  beta-2 adrenergic receptor-like [KO:K04142]
108799611  beta-4C adrenergic receptor-like [KO:K04143]
108787435  DRD1; D(1A) dopamine receptor [KO:K04144]
108792009  D(1C) dopamine receptor [KO:K05840]
108796576  DRD5; D(1B) dopamine receptor [KO:K05840]
108794958  octopamine receptor-like [KO:K04150]
108793722  histamine H2 receptor-like [KO:K04150]
108784291  HTR4; 5-hydroxytryptamine receptor 4 [KO:K04160]
108785022  HTR5A; 5-hydroxytryptamine receptor 5A [KO:K04161]
108800650  HTR6; 5-hydroxytryptamine receptor 6 [KO:K04162]
108792147  HTR7; 5-hydroxytryptamine receptor 7 [KO:K04163]
108795646  5-hydroxytryptamine receptor 7 [KO:K04163]
108802775  GNAS; guanine nucleotide-binding protein G(s) subunit alpha isoform X1 [KO:K04632]
108784456  guanine nucleotide-binding protein G(s) subunit alpha-like [KO:K04632]
108787315  GNAL; guanine nucleotide-binding protein G(olf) subunit alpha [KO:K04633]
108798434  guanine nucleotide-binding protein G(s) subunit alpha isoforms XLas-like [KO:K04633]
108796974  ADCY1; adenylate cyclase type 1 [KO:K08041] [EC:4.6.1.1]
108795542  ADCY3; adenylate cyclase type 3 [KO:K08043] [EC:4.6.1.1]
108788450  ADCY4; adenylate cyclase type 4 [KO:K08044] [EC:4.6.1.1]
108794932  ADCY7; adenylate cyclase type 7 [KO:K08047] [EC:4.6.1.1]
108788952  ADCY8; adenylate cyclase type 8 isoform X1 [KO:K08048] [EC:4.6.1.1]
108790811  ADCY9; adenylate cyclase type 9 [KO:K08049] [EC:4.6.1.1]
108784350  PRKACB; cAMP-dependent protein kinase catalytic subunit beta isoform X1 [KO:K04345] [EC:2.7.11.11]
108790539  cAMP-dependent protein kinase catalytic subunit alpha isoform X1 [KO:K04345] [EC:2.7.11.11]
108793005  PLN; cardiac phospholamban [KO:K05852]
108796096  sarcolipin [KO:K22642]
108796092  sarcolipin-like [KO:K22642]
108784529  ATP2A3; sarcoplasmic/endoplasmic reticulum calcium ATPase 3 [KO:K05853] [EC:7.2.2.10]
108802336  sarcoplasmic/endoplasmic reticulum calcium ATPase 1 isoform X1 [KO:K05853] [EC:7.2.2.10]
108796871  ATP2A2; sarcoplasmic/endoplasmic reticulum calcium ATPase 2 isoform X1 [KO:K05853] [EC:7.2.2.10]
108804008  stromal interaction molecule 1-like [KO:K16059]
108791034  STIM2; stromal interaction molecule 2 [KO:K18196]
108787479  ORAI1; calcium release-activated calcium channel protein 1 [KO:K16056]
108801888  ORAI2; protein orai-2 [KO:K16057]
108791575  voltage-dependent L-type calcium channel subunit alpha-1C-like isoform X1 [KO:K04850]
108786047  CACNA1D; voltage-dependent L-type calcium channel subunit alpha-1D [KO:K04851]
108788491  LOW QUALITY PROTEIN: voltage-dependent L-type calcium channel subunit alpha-1F-like [KO:K04853]
108804869  CACNA1S; voltage-dependent L-type calcium channel subunit alpha-1S [KO:K04857]
108794965  CACNA1A; voltage-dependent P/Q-type calcium channel subunit alpha-1A [KO:K04344]
108794388  CACNA1B; voltage-dependent N-type calcium channel subunit alpha-1B [KO:K04849]
108792573  CACNA1E; LOW QUALITY PROTEIN: voltage-dependent R-type calcium channel subunit alpha-1E [KO:K04852]
108796395  CACNA1G; voltage-dependent T-type calcium channel subunit alpha-1G isoform X1 [KO:K04854]
108793674  CACNA1H; voltage-dependent T-type calcium channel subunit alpha-1H isoform X1 [KO:K04855]
108796039  CACNA1I; voltage-dependent T-type calcium channel subunit alpha-1I [KO:K04856]
108793324  CHRNA7; neuronal acetylcholine receptor subunit alpha-7 [KO:K04809]
108788185  neuronal acetylcholine receptor subunit alpha-7-like [KO:K04809]
108795933  GRIN1; glutamate receptor ionotropic, NMDA 1 isoform X1 [KO:K05208]
108794358  GRIN2A; glutamate receptor ionotropic, NMDA 2A [KO:K05209]
108794295  GRIN2B; glutamate receptor ionotropic, NMDA 2B [KO:K05210]
108797027  GRIN2C; glutamate receptor ionotropic, NMDA 2C [KO:K05211]
108784206  GRIN2D; glutamate receptor ionotropic, NMDA 2D [KO:K05212]
108794278  GRIN3A; glutamate receptor ionotropic, NMDA 3A [KO:K05213]
108789494  GRIN3B; glutamate receptor ionotropic, NMDA 3B [KO:K05214]
108784527  P2RX1; P2X purinoceptor 1 [KO:K05215]
108786245  P2RX2; P2X purinoceptor 2 [KO:K05216]
108797057  P2RX3; P2X purinoceptor 3 [KO:K05217]
108787253  P2RX4; P2X purinoceptor 4 [KO:K05218]
108787949  P2RX5; P2X purinoceptor 5 isoform X1 [KO:K05219]
108800508  P2X purinoceptor 6-like [KO:K05221]
108787232  P2X purinoceptor 7-like [KO:K05220]
108787241  P2RX7; P2X purinoceptor 7 [KO:K05220]
108786654  RYR1; ryanodine receptor 1 [KO:K04961]
108785164  RYR3; ryanodine receptor 3 [KO:K04963]
108799143  TRDN; triadin [KO:K23449]
108801110  CASQ1; LOW QUALITY PROTEIN: calsequestrin-1 [KO:K23468]
108791345  ASPH; aspartyl/asparaginyl beta-hydroxylase [KO:K00476] [EC:1.14.11.16]
108796606  aspartyl/asparaginyl beta-hydroxylase-like [KO:K00476] [EC:1.14.11.16]
108799319  cysteinyl leukotriene receptor 1-like [KO:K04322]
108798881  CYSLTR1; cysteinyl leukotriene receptor 1 [KO:K04322]
108788723  CHRM2; muscarinic acetylcholine receptor M2 [KO:K04130]
108791007  alpha-1A adrenergic receptor-like [KO:K04135]
108788121  ADRA1B; alpha-1B adrenergic receptor [KO:K04136]
108796204  ADRA1D; alpha-1D adrenergic receptor [KO:K04137]
108797310  AGTR1; type-1 angiotensin II receptor [KO:K04166]
108794282  type-1 angiotensin II receptor-like [KO:K04166]
108802629  EDNRA; endothelin-1 receptor [KO:K04197]
108794348  EDNRB; endothelin B receptor [KO:K04198]
108795345  endothelin B receptor-like [KO:K04198]
108800466  proteinase-activated receptor 1-like [KO:K03914]
108800468  proteinase-activated receptor 1-like [KO:K03914]
108803052  proteinase-activated receptor 1-like [KO:K03914]
108803053  proteinase-activated receptor 1-like [KO:K03914]
108803054  proteinase-activated receptor 1-like [KO:K03914]
108800293  proteinase-activated receptor 1-like [KO:K03914]
108802574  proteinase-activated receptor 1-like [KO:K03914]
108802576  proteinase-activated receptor 1-like [KO:K03914]
108795383  proteinase-activated receptor 1-like [KO:K03914]
108801228  proteinase-activated receptor 1-like [KO:K03914]
108801230  proteinase-activated receptor 1-like [KO:K03914]
108789684  proteinase-activated receptor 1-like [KO:K03914]
108803536  proteinase-activated receptor 1-like [KO:K03914]
108802706  proteinase-activated receptor 1-like [KO:K03914]
108803777  proteinase-activated receptor 1-like [KO:K03914]
108803234  proteinase-activated receptor 1-like [KO:K03914]
108787660  proteinase-activated receptor 1-like [KO:K03914]
108787661  proteinase-activated receptor 1-like [KO:K03914]
108787741  GRM1; metabotropic glutamate receptor 1 [KO:K04603]
108794764  GRM5; metabotropic glutamate receptor 5 isoform X1 [KO:K04604]
108787950  GRPR; gastrin-releasing peptide receptor [KO:K04169]
108792925  HRH1; histamine H1 receptor [KO:K04149]
108804696  HTR2B; 5-hydroxytryptamine receptor 2B [KO:K04157]
108787214  HTR2C; 5-hydroxytryptamine receptor 2C [KO:K04157]
108797781  HTR2A; 5-hydroxytryptamine receptor 2A [KO:K04157]
108787595  LHCGR; lutropin-choriogonadotropic hormone receptor [KO:K04248]
108788597  NTSR2; neurotensin receptor type 2 [KO:K04211]
108789846  NTSR1; neurotensin receptor type 1 [KO:K04211]
108786020  OXTR; oxytocin receptor [KO:K04229]
108798284  vasopressin V1a receptor-like [KO:K04226]
108790948  AVPR1B; vasopressin V1b receptor [KO:K04227]
108792374  leukotriene B4 receptor 2-like [KO:K04297]
108795615  PTAFR; platelet-activating factor receptor [KO:K04279]
108797753  PTGER1; prostaglandin E2 receptor EP1 subtype [KO:K04258]
108804939  PTGER3; prostaglandin E2 receptor EP3 subtype [KO:K04260]
108789775  PTGFR; prostaglandin F2-alpha receptor [KO:K04262]
108788569  B2 bradykinin receptor-like [KO:K03916]
108788583  B2 bradykinin receptor-like [KO:K03916]
108788967  substance-P receptor isoform X1 [KO:K04222]
108798605  neuromedin-K receptor-like [KO:K04224]
108798697  TBXA2R; thromboxane A2 receptor [KO:K04264]
108790326  thyrotropin-releasing hormone receptor-like [KO:K04282]
108799023  TRHR; thyrotropin-releasing hormone receptor [KO:K04282]
108802657  thyrotropin-releasing hormone receptor-like [KO:K04282]
108791038  CCKAR; cholecystokinin receptor type A [KO:K04194]
108801206  cholecystokinin receptor-like [KO:K04194]
108791340  CXCR4; C-X-C chemokine receptor type 4 [KO:K04189]
108788493  guanine nucleotide-binding protein G(q) subunit alpha [KO:K04634]
108791250  GNA11; guanine nucleotide-binding protein subunit alpha-11 [KO:K04635]
108788497  GNA14; guanine nucleotide-binding protein subunit alpha-14 [KO:K04636]
108791249  guanine nucleotide-binding protein subunit alpha-11-like [KO:K04637]
108798307  EGF; pro-epidermal growth factor [KO:K04357]
108802996  protransforming growth factor alpha-like [KO:K08774]
108785348  TGFA; protransforming growth factor alpha [KO:K08774]
108800714  PDGFA; platelet-derived growth factor subunit A isoform X1 [KO:K04359]
108798502  PDGFB; platelet-derived growth factor subunit B [KO:K17386]
108789641  PDGFC; platelet-derived growth factor C [KO:K05450]
108794559  FGF1; fibroblast growth factor 1 [KO:K18496]
108790780  FGF2; fibroblast growth factor 2 [KO:K18497]
108792831  FGF18; fibroblast growth factor 18 [KO:K04358]
108793985  FGF9; fibroblast growth factor 9 [KO:K04358]
108794060  FGF8; fibroblast growth factor 8 isoform X1 [KO:K04358]
108796567  FGF10; fibroblast growth factor 10 [KO:K04358]
108794128  FGF20; fibroblast growth factor 20 [KO:K04358]
108792194  FGF7; fibroblast growth factor 7 [KO:K04358]
108789072  FGF5; fibroblast growth factor 5 [KO:K04358]
108788271  FGF6; fibroblast growth factor 6 [KO:K04358]
108785453  FGF3; fibroblast growth factor 3 [KO:K04358]
108785455  FGF4; fibroblast growth factor 4 [KO:K04358]
108785439  FGF19; fibroblast growth factor 19 [KO:K22603]
108787990  FGF23; fibroblast growth factor 23 [KO:K22428]
108800210  VEGFA; vascular endothelial growth factor A [KO:K05448]
108794236  VEGFB; vascular endothelial growth factor B [KO:K05448]
108792318  VEGFD; vascular endothelial growth factor D [KO:K05449]
108792718  VEGFC; vascular endothelial growth factor C [KO:K05449]
108795094  NGF; beta-nerve growth factor [KO:K02582]
108792728  HGF; hepatocyte growth factor [KO:K05460]
108803218  MST1; hepatocyte growth factor-like protein [KO:K23441]
108793608  GDNF; glial cell line-derived neurotrophic factor [KO:K05452]
108799381  epidermal growth factor receptor-like [KO:K04361] [EC:2.7.10.1]
108799518  epidermal growth factor receptor-like [KO:K04361] [EC:2.7.10.1]
108792756  ERBB2; receptor tyrosine-protein kinase erbB-2 [KO:K05083] [EC:2.7.10.1]
108790515  ERBB3; receptor tyrosine-protein kinase erbB-3 [KO:K05084] [EC:2.7.10.1]
108792763  ERBB4; receptor tyrosine-protein kinase erbB-4 [KO:K05085] [EC:2.7.10.1]
108804111  PDGFRA; platelet-derived growth factor receptor alpha isoform X1 [KO:K04363] [EC:2.7.10.1]
108785807  PDGFRB; platelet-derived growth factor receptor beta [KO:K05089] [EC:2.7.10.1]
108791453  FGFR1; fibroblast growth factor receptor 1 isoform X1 [KO:K04362] [EC:2.7.10.1]
108793050  FGFR2; fibroblast growth factor receptor 2 isoform X1 [KO:K05093] [EC:2.7.10.1]
108788840  FGFR3; fibroblast growth factor receptor 3 isoform X1 [KO:K05094] [EC:2.7.10.1]
108783764  FGFR4; fibroblast growth factor receptor 4 [KO:K05095] [EC:2.7.10.1]
108791089  vascular endothelial growth factor receptor kdr-like [KO:K05096] [EC:2.7.10.1]
108796337  FLT1; vascular endothelial growth factor receptor 1 [KO:K05096] [EC:2.7.10.1]
108785383  FLT4; vascular endothelial growth factor receptor 3 [KO:K05097] [EC:2.7.10.1]
108803904  KDR; vascular endothelial growth factor receptor 2 [KO:K05098] [EC:2.7.10.1]
108802180  NTRK1; high affinity nerve growth factor receptor [KO:K03176] [EC:2.7.10.1]
108798612  NTRK2; BDNF/NT-3 growth factors receptor isoform X1 [KO:K04360] [EC:2.7.10.1]
108786949  NTRK3; NT-3 growth factor receptor [KO:K05101] [EC:2.7.10.1]
108788984  MET; hepatocyte growth factor receptor [KO:K05099] [EC:2.7.10.1]
108803469  macrophage-stimulating protein receptor-like [KO:K05100] [EC:2.7.10.1]
108786609  RET; proto-oncogene tyrosine-protein kinase receptor Ret [KO:K05126] [EC:2.7.10.1]
108784616  PLCD1; 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase delta-1 [KO:K05857] [EC:3.1.4.11]
108785980  PLCD3; 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase delta-3 isoform X1 [KO:K05857] [EC:3.1.4.11]
108789286  PLCB2; 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-2 [KO:K05858] [EC:3.1.4.11]
108793965  PLCB3; 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-3 [KO:K05858] [EC:3.1.4.11]
108795563  PLCB1; 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-1 [KO:K05858] [EC:3.1.4.11]
108795338  PLCB4; 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-4 isoform X1 [KO:K05858] [EC:3.1.4.11]
108786812  PLCG1; 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1 [KO:K01116] [EC:3.1.4.11]
108789042  1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1-like [KO:K01116] [EC:3.1.4.11]
108786572  PLCG2; 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-2 [KO:K05859] [EC:3.1.4.11]
108792005  PLCE1; 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase epsilon-1 [KO:K05860] [EC:3.1.4.11]
108791809  PLCZ1; 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase zeta-1 [KO:K05861] [EC:3.1.4.11]
108791910  ITPR1; LOW QUALITY PROTEIN: inositol 1,4,5-trisphosphate receptor type 1 [KO:K04958]
108786728  ITPR2; inositol 1,4,5-trisphosphate receptor type 2 isoform X1 [KO:K04959]
108787281  ITPR3; LOW QUALITY PROTEIN: inositol 1,4,5-trisphosphate receptor type 3 [KO:K04960]
108799313  ADP-ribosyl cyclase/cyclic ADP-ribose hydrolase 1-like isoform X1 [KO:K01242] [EC:3.2.2.6 2.4.99.20]
108791301  TPCN1; two pore calcium channel protein 1 [KO:K16896]
108785440  TPCN2; two pore calcium channel protein 2 [KO:K14077]
108795663  MCOLN1; mucolipin-1 [KO:K04992]
108791378  MCOLN2; mucolipin-2 [KO:K04993]
108791382  MCOLN3; mucolipin-3 isoform X1 [KO:K04994]
108804675  SPHK2; sphingosine kinase 2 [KO:K04718] [EC:2.7.1.91]
108796856  SPHK1; sphingosine kinase 1 isoform X1 [KO:K04718] [EC:2.7.1.91]
108799532  MCU; calcium uniporter protein, mitochondrial [KO:K20858]
108804463  voltage-dependent anion-selective channel protein 1 [KO:K05862]
108788404  VDAC2; voltage-dependent anion-selective channel protein 2 [KO:K15040]
108791445  VDAC3; voltage-dependent anion-selective channel protein 3 isoform X1 [KO:K15041]
108798305  SLC25A5; ADP/ATP translocase 2 [KO:K05863]
108790928  SLC25A4; ADP/ATP translocase 1 [KO:K05863]
108796361  PPIF; peptidyl-prolyl cis-trans isomerase F, mitochondrial [KO:K09565] [EC:5.2.1.8]
108785592  peptidyl-prolyl cis-trans isomerase-like isoform X1 [KO:K09565] [EC:5.2.1.8]
108793959  troponin C, slow skeletal and cardiac muscles-like [KO:K05865]
108794414  troponin C, slow skeletal and cardiac muscles [KO:K05865]
108793376  TNNC2; troponin C, skeletal muscle isoform X1 [KO:K12042]
108799395  calmodulin-alpha-like [KO:K02183]
108784100  CALML4; calmodulin-like protein 4 isoform X1 [KO:K02183]
108804514  CALM2; calmodulin [KO:K02183]
108788690  CALM1; calmodulin isoform X1 [KO:K02183]
108799187  PHKG1; phosphorylase b kinase gamma catalytic chain, skeletal muscle/heart isoform [KO:K00871] [EC:2.7.11.19]
108803931  PHKG2; phosphorylase b kinase gamma catalytic chain, liver/testis isoform [KO:K00871] [EC:2.7.11.19]
108784400  PHKB; phosphorylase b kinase regulatory subunit beta isoform X1 [KO:K07190]
108785717  PHKA2; phosphorylase b kinase regulatory subunit alpha, liver isoform [KO:K07190]
108802964  MYLK3; myosin light chain kinase 3 [KO:K00907] [EC:2.7.11.18]
108787381  MYLK4; myosin light chain kinase family member 4 [KO:K00907] [EC:2.7.11.18]
108785969  myosin light chain kinase, smooth muscle-like [KO:K00907] [EC:2.7.11.18]
108784810  CAMK1D; calcium/calmodulin-dependent protein kinase type 1D [KO:K08794] [EC:2.7.11.17]
108804406  CAMK1; calcium/calmodulin-dependent protein kinase type 1 [KO:K08794] [EC:2.7.11.17]
108804479  CAMK2G; calcium/calmodulin-dependent protein kinase type II subunit gamma isoform X1 [KO:K04515] [EC:2.7.11.17]
108785806  CAMK2A; calcium/calmodulin-dependent protein kinase type II subunit alpha isoform X1 [KO:K04515] [EC:2.7.11.17]
108785601  CAMK2B; calcium/calmodulin-dependent protein kinase type II subunit beta isoform X1 [KO:K04515] [EC:2.7.11.17]
108798063  calcium/calmodulin-dependent protein kinase type II subunit delta-like [KO:K04515] [EC:2.7.11.17]
108792885  CAMK4; calcium/calmodulin-dependent protein kinase type IV [KO:K05869] [EC:2.7.11.17]
108793483  calcium/calmodulin-dependent protein kinase type IV-like [KO:K05869] [EC:2.7.11.17]
108792819  PPP3CC; serine/threonine-protein phosphatase 2B catalytic subunit gamma isoform [KO:K04348] [EC:3.1.3.16]
108793505  PPP3CB; serine/threonine-protein phosphatase 2B catalytic subunit beta isoform isoform X1 [KO:K04348] [EC:3.1.3.16]
108789057  PPP3CA; serine/threonine-protein phosphatase 2B catalytic subunit alpha isoform isoform X1 [KO:K04348] [EC:3.1.3.16]
108795656  PPP3R1; calcineurin subunit B type 1 [KO:K06268]
108804874  TFEB; transcription factor EB [KO:K15590]
108784253  NFATC1; nuclear factor of activated T-cells, cytoplasmic 1 [KO:K04446]
108795666  NFATC2; nuclear factor of activated T-cells, cytoplasmic 2 [KO:K17332]
108789084  NFATC3; nuclear factor of activated T-cells, cytoplasmic 3 isoform X1 [KO:K17333]
108792372  NFATC4; nuclear factor of activated T-cells, cytoplasmic 4 [KO:K17334]
108785232  NOS1; nitric oxide synthase, brain [KO:K13240] [EC:1.14.13.39]
108801680  NOS2; nitric oxide synthase, inducible [KO:K13241] [EC:1.14.13.39]
108803428  LOW QUALITY PROTEIN: nitric oxide synthase, endothelial-like [KO:K13242] [EC:1.14.13.39]
108794254  PDE1C; calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1C [KO:K13755] [EC:3.1.4.17]
108797370  PDE1B; calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1B isoform X1 [KO:K13755] [EC:3.1.4.17]
108789484  PDE1A; calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A [KO:K13755] [EC:3.1.4.17]
108801309  protein-tyrosine kinase 2-beta-like [KO:K05871] [EC:2.7.10.2]
108799223  inositol-trisphosphate 3-kinase A-like [KO:K00911] [EC:2.7.1.127]
108791942  ITPKC; inositol-trisphosphate 3-kinase C [KO:K00911] [EC:2.7.1.127]
108796873  ITPKB; inositol-trisphosphate 3-kinase B [KO:K00911] [EC:2.7.1.127]
108791355  PRKCB; protein kinase C beta type isoform X1 [KO:K19662] [EC:2.7.11.13]
108797498  PRKCG; protein kinase C gamma type isoform X1 [KO:K19663] [EC:2.7.11.13]
Compound
C00002  ATP
C00004  NADH
C00076  Calcium cation
C00165  Diacylglycerol
C00575  3',5'-Cyclic AMP
C01245  D-myo-Inositol 1,4,5-trisphosphate
C01330  Sodium cation
C06124  Sphingosine 1-phosphate
C11556  1-Phosphatidyl-1D-myo-inositol 3,5-bisphosphate
C13050  Cyclic ADP-ribose
C13051  Nicotinic acid adenine dinucleotide phosphate
Reference
PMID:12838335
  Authors
Berridge MJ, Bootman MD, Roderick HL.
  Title
Calcium signalling: dynamics, homeostasis and remodelling.
  Journal
Nat Rev Mol Cell Biol 4:517-29 (2003)
DOI:10.1038/nrm1155
Reference
PMID:11413485
  Authors
Berridge MJ, Lipp P, Bootman MD.
  Title
The versatility and universality of calcium signalling.
  Journal
Nat Rev Mol Cell Biol 1:11-21 (2000)
DOI:10.1038/35036035
Reference
PMID:15111104
  Authors
Wang MC, Dolphin A, Kitmitto A.
  Title
L-type voltage-gated calcium channels: understanding function through structure.
  Journal
FEBS Lett 564:245-50 (2004)
DOI:10.1016/S0014-5793(04)00253-4
Reference
PMID:11299192
  Authors
Ferrier GR, Howlett SE.
  Title
Cardiac excitation-contraction coupling: role of membrane potential in regulation of contraction.
  Journal
Am J Physiol Heart Circ Physiol 280:H1928-44 (2001)
DOI:10.1152/ajpheart.2001.280.5.H1928
Reference
PMID:11698232
  Authors
Keef KD, Hume JR, Zhong J.
  Title
Regulation of cardiac and smooth muscle Ca(2+) channels (Ca(V)1.2a,b) by protein kinases.
  Journal
Am J Physiol Cell Physiol 281:C1743-56 (2001)
DOI:10.1152/ajpcell.2001.281.6.C1743
Reference
PMID:8125957
  Authors
Hell JW, Appleyard SM, Yokoyama CT, Warner C, Catterall WA.
  Title
Differential phosphorylation of two size forms of the N-type calcium channel alpha 1 subunit which have different COOH termini.
  Journal
J Biol Chem 269:7390-6 (1994)
Reference
PMID:15000521
  Authors
Yunker AM.
  Title
Modulation and pharmacology of low voltage-activated ("T-Type") calcium channels.
  Journal
J Bioenerg Biomembr 35:577-98 (2003)
DOI:10.1023/B:JOBB.0000008025.65675.37
Reference
PMID:9149541
  Authors
Yakel JL.
  Title
Calcineurin regulation of synaptic function: from ion channels to transmitter release and gene transcription.
  Journal
Trends Pharmacol Sci 18:124-34 (1997)
DOI:10.1016/S0165-6147(97)01046-8
Reference
PMID:10997573
  Authors
Fukunaga K, Miyamoto E.
  Title
A working model of CaM kinase II activity in hippocampal long-term potentiation and memory.
  Journal
Neurosci Res 38:3-17 (2000)
DOI:10.1016/S0168-0102(00)00139-5
Reference
PMID:9235901
  Authors
Della Rocca GJ, van Biesen T, Daaka Y, Luttrell DK, Luttrell LM, Lefkowitz RJ.
  Title
Ras-dependent mitogen-activated protein kinase activation by G protein-coupled receptors. Convergence of Gi- and Gq-mediated pathways on calcium/calmodulin, Pyk2, and Src kinase.
  Journal
J Biol Chem 272:19125-32 (1997)
DOI:10.1074/jbc.272.31.19125
Reference
PMID:7861177
  Authors
Furuichi T, Mikoshiba K.
  Title
Inositol 1, 4, 5-trisphosphate receptor-mediated Ca2+ signaling in the brain.
  Journal
J Neurochem 64:953-60 (1995)
DOI:10.1046/j.1471-4159.1995.64030953.x
Reference
PMID:14572802
  Authors
Bruce JI, Straub SV, Yule DI.
  Title
Crosstalk between cAMP and Ca2+ signaling in non-excitable cells.
  Journal
Cell Calcium 34:431-44 (2003)
DOI:10.1016/S0143-4160(03)00150-7
Reference
PMID:10331643
  Authors
Lee HC, Munshi C, Graeff R.
  Title
Structures and activities of cyclic ADP-ribose, NAADP and their metabolic enzymes.
  Journal
Mol Cell Biochem 193:89-98 (1999)
DOI:10.1007/978-1-4419-8740-2_13
Reference
PMID:11080247
  Authors
Crompton M.
  Title
Mitochondrial intermembrane junctional complexes and their role in cell death.
  Journal
J Physiol 529 Pt 1:11-21 (2000)
DOI:10.1111/j.1469-7793.2000.00011.x
Reference
PMID:10508738
  Authors
Grewal SS, York RD, Stork PJ.
  Title
Extracellular-signal-regulated kinase signalling in neurons.
  Journal
Curr Opin Neurobiol 9:544-53 (1999)
DOI:10.1016/S0959-4388(99)00010-0
Reference
PMID:12972622
  Authors
Trushin SA, Pennington KN, Carmona EM, Asin S, Savoy DN, Billadeau DD, Paya CV.
  Title
Protein kinase Calpha (PKCalpha) acts upstream of PKCtheta to activate IkappaB kinase and NF-kappaB in T lymphocytes.
  Journal
Mol Cell Biol 23:7068-81 (2003)
DOI:10.1128/MCB.23.19.7068-7081.2003
Reference
PMID:14517314
  Authors
Hutchins JR, Dikovskaya D, Clarke PR.
  Title
Regulation of Cdc2/cyclin B activation in Xenopus egg extracts via inhibitory phosphorylation of Cdc25C phosphatase by Ca(2+)/calmodulin-dependent protein [corrected] kinase II.
  Journal
Mol Biol Cell 14:4003-14 (2003)
DOI:10.1091/mbc.E03-02-0061
Reference
PMID:21338471
  Authors
Tornquist K
  Title
Sphingosine 1-phosphate, sphingosine kinase and autocrine calcium signalling in thyroid cells.
  Journal
Acta Physiol (Oxf) 204:151-7 (2012)
DOI:10.1111/j.1748-1716.2011.02265.x
Reference
PMID:22129055
  Authors
Feske S
  Title
Immunodeficiency due to defects in store-operated calcium entry.
  Journal
Ann N Y Acad Sci 1238:74-90 (2011)
DOI:10.1111/j.1749-6632.2011.06240.x
Reference
PMID:22002090
  Authors
Giachini FR, Lima VV, Hannan JL, Carneiro FS, Webb RC, Tostes RC
  Title
STIM1/Orai1-mediated store-operated Ca2+ entry: the tip of the iceberg.
  Journal
Braz J Med Biol Res 44:1080-7 (2011)
DOI:10.1590/S0100-879X2011007500133
Reference
PMID:19172794
  Authors
Baba Y, Kurosaki T
  Title
[Regulation of store-operated calcium entry by STIM1].
  Journal
Seikagaku 80:1123-8 (2008)
Reference
PMID:19475418
  Authors
Galione A, Evans AM, Ma J, Parrington J, Arredouani A, Cheng X, Zhu MX
  Title
The acid test: the discovery of two-pore channels (TPCs) as NAADP-gated endolysosomal Ca(2+) release channels.
  Journal
Pflugers Arch 458:869-76 (2009)
DOI:10.1007/s00424-009-0682-y
Reference
PMID:19434403
  Authors
Beard NA, Wei L, Dulhunty AF
  Title
Ca(2+) signaling in striated muscle: the elusive roles of triadin, junctin, and calsequestrin.
  Journal
Eur Biophys J 39:27-36 (2009)
DOI:10.1007/s00249-009-0449-6
Reference
PMID:26228554
  Authors
Marty I
  Title
Triadin regulation of the ryanodine receptor complex.
  Journal
J Physiol 593:3261-6 (2015)
DOI:10.1113/jphysiol.2014.281147
Reference
PMID:20807542
  Authors
Arvanitis DA, Vafiadaki E, Sanoudou D, Kranias EG
  Title
Histidine-rich calcium binding protein: the new regulator of sarcoplasmic reticulum calcium cycling.
  Journal
J Mol Cell Cardiol 50:43-9 (2011)
DOI:10.1016/j.yjmcc.2010.08.021
Related
pathway
npr04010  MAPK signaling pathway
npr04070  Phosphatidylinositol signaling system
npr04210  Apoptosis
KO pathway
ko04020   
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