KEGG   PATHWAY: npr04010
Entry
npr04010                    Pathway                                
Name
MAPK signaling pathway - Nanorana parkeri (Xizang Plateau frog)
Description
The mitogen-activated protein kinase (MAPK) cascade is a highly conserved module that is involved in various cellular functions, including cell proliferation, differentiation and migration. Mammals express at least four distinctly regulated groups of MAPKs, extracellular signal-related kinases (ERK)-1/2, Jun amino-terminal kinases (JNK1/2/3), p38 proteins (p38alpha/beta/gamma/delta) and ERK5, that are activated by specific MAPKKs: MEK1/2 for ERK1/2, MKK3/6 for the p38, MKK4/7 (JNKK1/2) for the JNKs, and MEK5 for ERK5. Each MAPKK, however, can be activated by more than one MAPKKK, increasing the complexity and diversity of MAPK signalling. Presumably each MAPKKK confers responsiveness to distinct stimuli. For example, activation of ERK1/2 by growth factors depends on the MAPKKK c-Raf, but other MAPKKKs may activate ERK1/2 in response to pro-inflammatory stimuli.
Class
Environmental Information Processing; Signal transduction
Pathway map
npr04010  MAPK signaling pathway
npr04010

Disease
H02157  Short-rib thoracic dysplasia
Other DBs
GO: 0000165
Organism
Nanorana parkeri (Xizang Plateau frog) [GN:npr]
Gene
108783678  RAC2; ras-related C3 botulinum toxin substrate 2 [KO:K07860]
108783688  CACNG2; voltage-dependent calcium channel gamma-2 subunit [KO:K04867]
108783724  MAPK8IP3; C-Jun-amino-terminal kinase-interacting protein 3 isoform X1 [KO:K04436]
108783764  FGFR4; fibroblast growth factor receptor 4 [KO:K05095] [EC:2.7.10.1]
108784008  NGFR; tumor necrosis factor receptor superfamily member 16 [KO:K02583]
108784075  MAP2K5; dual specificity mitogen-activated protein kinase kinase 5 [KO:K04463] [EC:2.7.12.2]
108784101  MAP2K1; dual specificity mitogen-activated protein kinase kinase 1 [KO:K04368] [EC:2.7.12.2]
108784114  RELA; transcription factor p65 [KO:K04735]
108784170  RASGRP3; ras guanyl-releasing protein 3 [KO:K12362]
108784253  NFATC1; nuclear factor of activated T-cells, cytoplasmic 1 [KO:K04446]
108784350  PRKACB; cAMP-dependent protein kinase catalytic subunit beta isoform X1 [KO:K04345] [EC:2.7.11.11]
108784458  AREG; amphiregulin [KO:K09782]
108784459  [KO:K09784]
108784622  [KO:K04421] [EC:2.7.11.25]
108784626  MYD88; myeloid differentiation primary response protein MyD88 [KO:K04729]
108784717  CACNB4; voltage-dependent L-type calcium channel subunit beta-4 isoform X1 [KO:K04865]
108784730  [KO:K04451]
108785125  MAP4K4; mitogen-activated protein kinase kinase kinase kinase 4 isoform X1 [KO:K04407] [EC:2.7.11.1]
108785170  RASGRP1; RAS guanyl-releasing protein 1 [KO:K04350]
108785348  TGFA; protransforming growth factor alpha [KO:K08774]
108785383  FLT4; vascular endothelial growth factor receptor 3 [KO:K05097] [EC:2.7.10.1]
108785393  MAP3K2; mitogen-activated protein kinase kinase kinase 2 [KO:K04420] [EC:2.7.11.25]
108785439  FGF19; fibroblast growth factor 19 [KO:K22603]
108785453  FGF3; fibroblast growth factor 3 [KO:K04358]
108785455  FGF4; fibroblast growth factor 4 [KO:K04358]
108785459  MAPK8IP1; C-Jun-amino-terminal kinase-interacting protein 1 isoform X1 [KO:K04434]
108785487  NFKB2; nuclear factor NF-kappa-B p100 subunit [KO:K04469]
108785545  [KO:K03283]
108785587  [KO:K04519]
108785600  [KO:K04519]
108785712  RPS6KA3; ribosomal protein S6 kinase alpha-3 [KO:K04373] [EC:2.7.11.1]
108785796  CSF1R; macrophage colony-stimulating factor 1 receptor [KO:K05090] [EC:2.7.10.1]
108785807  PDGFRB; platelet-derived growth factor receptor beta [KO:K05089] [EC:2.7.10.1]
108785893  INSR; insulin receptor [KO:K04527] [EC:2.7.10.1]
108785951  PTPN5; tyrosine-protein phosphatase non-receptor type 5 [KO:K18018] [EC:3.1.3.48]
108785983  MAP3K14; mitogen-activated protein kinase kinase kinase 14 [KO:K04466] [EC:2.7.11.25]
108786047  CACNA1D; voltage-dependent L-type calcium channel subunit alpha-1D [KO:K04851]
108786049  CACNA2D3; LOW QUALITY PROTEIN: voltage-dependent calcium channel subunit alpha-2/delta-3 [KO:K04860]
108786609  RET; proto-oncogene tyrosine-protein kinase receptor Ret [KO:K05126] [EC:2.7.10.1]
108786653  MAP4K1; mitogen-activated protein kinase kinase kinase kinase 1 [KO:K04408] [EC:2.7.11.1]
108786689  HRAS; GTPase HRas [KO:K02833]
108786829  MAP3K12; mitogen-activated protein kinase kinase kinase 12 [KO:K04423] [EC:2.7.11.25]
108787040  PPM1B; protein phosphatase 1B isoform X1 [KO:K04461] [EC:3.1.3.16]
108787082  TEK; angiopoietin-1 receptor isoform X1 [KO:K05121] [EC:2.7.10.1]
108787157  AKT1; RAC-alpha serine/threonine-protein kinase [KO:K04456] [EC:2.7.11.1]
108787228  KITLG; kit ligand [KO:K05461]
108787235  DUSP6; dual specificity protein phosphatase 6 isoform X1 [KO:K21946] [EC:3.1.3.16 3.1.3.48]
108787259  TRAF2; TNF receptor-associated factor 2 [KO:K03173] [EC:2.3.2.27]
108787378  [KO:K04441] [EC:2.7.11.24]
108787404  MAP3K5; mitogen-activated protein kinase kinase kinase 5 [KO:K04426] [EC:2.7.11.25]
108787513  IGF1R; insulin-like growth factor 1 receptor [KO:K05087] [EC:2.7.10.1]
108787573  [KO:K04366] [EC:2.7.11.1]
108787585  [KO:K04374]
108787821  TRAF6; TNF receptor-associated factor 6 [KO:K03175] [EC:2.3.2.27]
108787990  FGF23; fibroblast growth factor 23 [KO:K22428]
108788059  MECOM; MDS1 and EVI1 complex locus protein EVI1 isoform X1 [KO:K04462] [EC:2.1.1.367]
108788164  JUN; transcription factor AP-1 [KO:K04448]
108788240  [KO:K04441] [EC:2.7.11.24]
108788271  FGF6; fibroblast growth factor 6 [KO:K04358]
108788354  DAXX; death domain-associated protein 6 [KO:K02308]
108788491  [KO:K04853]
108788534  MAPKAPK5; MAP kinase-activated protein kinase 5 isoform X1 [KO:K04442] [EC:2.7.11.1]
108788656  [KO:K04407] [EC:2.7.11.1]
108788677  RPS6KA5; ribosomal protein S6 kinase alpha-5 isoform X1 [KO:K04445] [EC:2.7.11.1]
108788764  DUSP1; dual specificity protein phosphatase 1 [KO:K21278] [EC:3.1.3.16 3.1.3.48]
108788840  FGFR3; fibroblast growth factor receptor 3 isoform X1 [KO:K05094] [EC:2.7.10.1]
108788845  MAP3K8; mitogen-activated protein kinase kinase kinase 8 [KO:K04415] [EC:2.7.11.25]
108788944  MAP4K3; mitogen-activated protein kinase kinase kinase kinase 3 [KO:K04406] [EC:2.7.11.1]
108788949  SOS1; son of sevenless homolog 1 [KO:K03099]
108788968  MYC; myc proto-oncogene protein [KO:K04377]
108788984  MET; hepatocyte growth factor receptor [KO:K05099] [EC:2.7.10.1]
108789040  [KO:K25415]
108789057  PPP3CA; serine/threonine-protein phosphatase 2B catalytic subunit alpha isoform isoform X1 [KO:K04348] [EC:3.1.3.16]
108789059  NFKB1; nuclear factor NF-kappa-B p105 subunit [KO:K02580]
108789072  FGF5; fibroblast growth factor 5 [KO:K04358]
108789084  NFATC3; nuclear factor of activated T-cells, cytoplasmic 3 isoform X1 [KO:K17333]
108789153  STK3; serine/threonine-protein kinase 3 isoform X1 [KO:K04412]
108789155  [KO:K04468] [EC:2.7.11.24]
108789168  TAOK2; serine/threonine-protein kinase TAO2 isoform X1 [KO:K04429] [EC:2.7.11.1]
108789272  MEF2C; myocyte-specific enhancer factor 2C isoform X1 [KO:K04454]
108789293  PLA2G4F; cytosolic phospholipase A2 zeta [KO:K16342] [EC:3.1.1.4]
108789386  TAB2; TGF-beta-activated kinase 1 and MAP3K7-binding protein 2 isoform X1 [KO:K04404]
108789468  IRAK4; LOW QUALITY PROTEIN: interleukin-1 receptor-associated kinase 4 [KO:K04733] [EC:2.7.11.1]
108789614  IGF1; insulin-like growth factor I [KO:K05459]
108789632  NRTN; neurturin [KO:K25414]
108789641  PDGFC; platelet-derived growth factor C [KO:K05450]
108789680  RAP1A; ras-related protein Rap-1A [KO:K04353]
108789917  [KO:K16342] [EC:3.1.1.4]
108790146  RASA2; ras GTPase-activating protein 2 [KO:K08053]
108790159  PAK2; serine/threonine-protein kinase PAK 2 [KO:K04410] [EC:2.7.11.1]
108790401  [KO:K03283]
108790442  IRAK1; interleukin-1 receptor-associated kinase 1 [KO:K04730] [EC:2.7.11.1]
108790450  FLNA; filamin-A isoform X1 [KO:K04437]
108790515  ERBB3; receptor tyrosine-protein kinase erbB-3 [KO:K05084] [EC:2.7.10.1]
108790539  [KO:K04345] [EC:2.7.11.11]
108790540  MAP2K7; dual specificity mitogen-activated protein kinase kinase 7 isoform X1 [KO:K04431] [EC:2.7.12.2]
108790588  HSPA8; heat shock cognate 71 kDa protein [KO:K03283]
108790734  CACNB1; voltage-dependent L-type calcium channel subunit beta-1 isoform X1 [KO:K04862]
108790780  FGF2; fibroblast growth factor 2 [KO:K18497]
108790893  ELK4; ETS domain-containing protein Elk-4 [KO:K04376]
108790926  CACNG3; voltage-dependent calcium channel gamma-3 subunit [KO:K04868]
108791003  RASGRF1; ras-specific guanine nucleotide-releasing factor 1 [KO:K04349]
108791089  [KO:K05096] [EC:2.7.10.1]
108791112  RELB; transcription factor RelB [KO:K09253]
108791159  GRB2; growth factor receptor-bound protein 2 isoform X1 [KO:K04364]
108791334  RAC3; ras-related C3 botulinum toxin substrate 3 [KO:K07861]
108791352  IKBKG; NF-kappa-B essential modulator [KO:K07210]
108791355  PRKCB; protein kinase C beta type isoform X1 [KO:K19662] [EC:2.7.11.13]
108791446  IKBKB; inhibitor of nuclear factor kappa-B kinase subunit beta [KO:K07209] [EC:2.7.11.10]
108791453  FGFR1; fibroblast growth factor receptor 1 isoform X1 [KO:K04362] [EC:2.7.10.1]
108791492  ARRB2; beta-arrestin-2 [KO:K04439]
108791570  DUSP16; dual specificity protein phosphatase 16 [KO:K04459] [EC:3.1.3.16 3.1.3.48]
108791575  [KO:K04850]
108791705  RAPGEF2; rap guanine nucleotide exchange factor 2 isoform X1 [KO:K08018]
108791874  [KO:K04374]
108791922  PPM1A; protein phosphatase 1A [KO:K04457] [EC:3.1.3.16]
108791934  DUSP5; dual specificity protein phosphatase 5 [KO:K04459] [EC:3.1.3.16 3.1.3.48]
108791995  IGF2; insulin-like growth factor II isoform X1 [KO:K13769]
108792002  INS; insulin [KO:K04526]
108792018  MAP3K1; mitogen-activated protein kinase kinase kinase 1 [KO:K04416] [EC:2.7.11.25]
108792022  NTF3; neurotrophin-3 isoform X1 [KO:K04356]
108792108  [KO:K04459] [EC:3.1.3.16 3.1.3.48]
108792194  FGF7; fibroblast growth factor 7 [KO:K04358]
108792234  [KO:K04388] [EC:2.7.11.30]
108792318  VEGFD; vascular endothelial growth factor D [KO:K05449]
108792573  CACNA1E; LOW QUALITY PROTEIN: voltage-dependent R-type calcium channel subunit alpha-1E [KO:K04852]
108792619  TAOK1; serine/threonine-protein kinase TAO1 isoform X1 [KO:K04429] [EC:2.7.11.1]
108792718  VEGFC; vascular endothelial growth factor C [KO:K05449]
108792727  CACNA2D1; voltage-dependent calcium channel subunit alpha-2/delta-1 [KO:K04858]
108792728  HGF; hepatocyte growth factor [KO:K05460]
108792756  ERBB2; receptor tyrosine-protein kinase erbB-2 [KO:K05083] [EC:2.7.10.1]
108792763  ERBB4; receptor tyrosine-protein kinase erbB-4 [KO:K05085] [EC:2.7.10.1]
108792786  STMN1; stathmin [KO:K04381]
108792819  PPP3CC; serine/threonine-protein phosphatase 2B catalytic subunit gamma isoform [KO:K04348] [EC:3.1.3.16]
108792831  FGF18; fibroblast growth factor 18 [KO:K04358]
108793029  BRAF; serine/threonine-protein kinase B-raf [KO:K04365] [EC:2.7.11.1]
108793050  FGFR2; fibroblast growth factor receptor 2 isoform X1 [KO:K05093] [EC:2.7.10.1]
108793101  JUND; transcription factor jun-D [KO:K04449]
108793180  MAPKAPK2; MAP kinase-activated protein kinase 2 [KO:K04443] [EC:2.7.11.1]
108793289  [KO:K04872]
108793291  [KO:K04873]
108793350  LAMTOR3; ragulator complex protein LAMTOR3 [KO:K04370]
108793363  CACNB2; voltage-dependent L-type calcium channel subunit beta-2 isoform X1 [KO:K04863]
108793469  MAPK8IP2; C-Jun-amino-terminal kinase-interacting protein 2 [KO:K04435]
108793505  PPP3CB; serine/threonine-protein phosphatase 2B catalytic subunit beta isoform isoform X1 [KO:K04348] [EC:3.1.3.16]
108793608  GDNF; glial cell line-derived neurotrophic factor [KO:K05452]
108793674  CACNA1H; voltage-dependent T-type calcium channel subunit alpha-1H isoform X1 [KO:K04855]
108793685  [KO:K04411]
108793742  [KO:K03156]
108793910  TRADD; tumor necrosis factor receptor type 1-associated DEATH domain protein [KO:K03171]
108793921  [KO:K16342] [EC:3.1.1.4]
108793985  FGF9; fibroblast growth factor 9 [KO:K04358]
108794037  [KO:K16510] [EC:2.7.11.1]
108794060  FGF8; fibroblast growth factor 8 isoform X1 [KO:K04358]
108794093  MAP3K10; mitogen-activated protein kinase kinase kinase 10 isoform X1 [KO:K04418] [EC:2.7.11.25]
108794095  AKT2; RAC-beta serine/threonine-protein kinase [KO:K04456] [EC:2.7.11.1]
108794128  FGF20; fibroblast growth factor 20 [KO:K04358]
108794177  [KO:K20216] [EC:3.1.3.16 3.1.3.48]
108794206  RASGRF2; ras-specific guanine nucleotide-releasing factor 2 [KO:K12326]
108794236  VEGFB; vascular endothelial growth factor B [KO:K05448]
108794388  CACNA1B; voltage-dependent N-type calcium channel subunit alpha-1B [KO:K04849]
108794413  [KO:K04459] [EC:3.1.3.16 3.1.3.48]
108794473  RAC1; ras-related C3 botulinum toxin substrate 1 [KO:K04392]
108794525  DUSP4; dual specificity protein phosphatase 4 isoform X1 [KO:K04459] [EC:3.1.3.16 3.1.3.48]
108794559  FGF1; fibroblast growth factor 1 [KO:K18496]
108794589  [KO:K02187] [EC:3.4.22.56]
108794597  [KO:K02187] [EC:3.4.22.56]
108794648  [KO:K04440] [EC:2.7.11.24]
108794760  EFNA5; ephrin-A5 isoform X1 [KO:K05462]
108794769  EFNA3; ephrin-A3 [KO:K05462]
108794776  EFNA1; ephrin-A1 [KO:K05462]
108794889  MAPK1; mitogen-activated protein kinase 1 [KO:K04371] [EC:2.7.11.24]
108794963  PSPN; persephin [KO:K25416]
108794965  CACNA1A; voltage-dependent P/Q-type calcium channel subunit alpha-1A [KO:K04344]
108795048  MAP3K4; mitogen-activated protein kinase kinase kinase 4 isoform X1 [KO:K04428] [EC:2.7.11.25]
108795058  DUSP3; dual specificity protein phosphatase 3 [KO:K17614] [EC:3.1.3.16 3.1.3.48]
108795074  SOS2; son of sevenless homolog 2 isoform X1 [KO:K03099]
108795094  NGF; beta-nerve growth factor [KO:K02582]
108795190  [KO:K05462]
108795520  GADD45G; growth arrest and DNA damage-inducible protein GADD45 gamma [KO:K04402]
108795559  FASLG; tumor necrosis factor ligand superfamily member 6 [KO:K04389]
108795599  MAP3K13; mitogen-activated protein kinase kinase kinase 13 [KO:K04422] [EC:2.7.11.25]
108795656  PPP3R1; calcineurin subunit B type 1 [KO:K06268]
108795797  TGFB2; transforming growth factor beta-2 isoform X1 [KO:K13376]
108795947  GADD45A; growth arrest and DNA damage-inducible protein GADD45 alpha [KO:K04402]
108795949  GNG12; guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-12 [KO:K04347]
108795999  TNFRSF1A; tumor necrosis factor receptor superfamily member 1A [KO:K03158]
108796039  CACNA1I; voltage-dependent T-type calcium channel subunit alpha-1I [KO:K04856]
108796167  ANGPT2; angiopoietin-2 isoform X1 [KO:K05466]
108796333  BDNF; brain-derived neurotrophic factor isoform X1 [KO:K04355]
108796337  FLT1; vascular endothelial growth factor receptor 1 [KO:K05096] [EC:2.7.10.1]
108796338  FLT3; receptor-type tyrosine-protein kinase FLT3 [KO:K05092] [EC:2.7.10.1]
108796395  CACNA1G; voltage-dependent T-type calcium channel subunit alpha-1G isoform X1 [KO:K04854]
108796459  SRF; serum response factor isoform X1 [KO:K04378]
108796567  FGF10; fibroblast growth factor 10 [KO:K04358]
108797141  MRAS; ras-related protein M-Ras [KO:K07831]
108797196  [KO:K03283]
108797397  CDC42; cell division control protein 42 homolog isoform X1 [KO:K04393]
108797497  TAOK3; serine/threonine-protein kinase TAO3 [KO:K04429] [EC:2.7.11.1]
108797498  PRKCG; protein kinase C gamma type isoform X1 [KO:K19663] [EC:2.7.11.13]
108797515  [KO:K07830]
108797553  KRAS; GTPase KRas isoform X1 [KO:K07827]
108797654  CHUK; inhibitor of nuclear factor kappa-B kinase subunit alpha [KO:K04467] [EC:2.7.11.10]
108797835  DDIT3; DNA damage-inducible transcript 3 protein [KO:K04452]
108797984  CDC25B; M-phase inducer phosphatase 2 [KO:K05866] [EC:3.1.3.48]
108798164  TAB1; TGF-beta-activated kinase 1 and MAP3K7-binding protein 1 [KO:K04403]
108798307  EGF; pro-epidermal growth factor [KO:K04357]
108798502  PDGFB; platelet-derived growth factor subunit B [KO:K17386]
108798575  NF1; neurofibromin [KO:K08052]
108798612  NTRK2; BDNF/NT-3 growth factors receptor isoform X1 [KO:K04360] [EC:2.7.10.1]
108798619  NR4A1; nuclear receptor subfamily 4 group A member 1 [KO:K04465]
108798643  GADD45B; growth arrest and DNA damage-inducible protein GADD45 beta [KO:K04402]
108798704  PLA2G4A; cytosolic phospholipase A2 [KO:K16342] [EC:3.1.1.4]
108798917  ANGPT1; angiopoietin-1 isoform X1 [KO:K05465]
108798954  [KO:K05462]
108799247  TGFBR1; TGF-beta receptor type-1 isoform X1 [KO:K04674] [EC:2.7.11.30]
108799257  HSPB1; heat shock protein beta-1 [KO:K04455]
108799381  [KO:K04361] [EC:2.7.10.1]
108799518  [KO:K04361] [EC:2.7.10.1]
108799544  NRAS; GTPase NRas [KO:K07828]
108799653  [KO:K04373] [EC:2.7.11.1]
108799902  [KO:K02583]
108800079  [KO:K13769]
108800110  MAP3K7; mitogen-activated protein kinase kinase kinase 7 isoform X1 [KO:K04427] [EC:2.7.11.25]
108800151  DUSP10; dual specificity protein phosphatase 10 [KO:K20216] [EC:3.1.3.16 3.1.3.48]
108800155  [KO:K04381]
108800210  VEGFA; vascular endothelial growth factor A [KO:K05448]
108800280  RASGRP2; RAS guanyl-releasing protein 2 [KO:K12361]
108800395  ATF2; cyclic AMP-dependent transcription factor ATF-2 [KO:K04450]
108800427  RASA1; ras GTPase-activating protein 1 isoform X1 [KO:K04352]
108800631  [KO:K04424] [EC:2.7.11.25]
108800678  MAPK7; mitogen-activated protein kinase 7 [KO:K04464] [EC:2.7.11.24]
108800714  PDGFA; platelet-derived growth factor subunit A isoform X1 [KO:K04359]
108800768  [KO:K13375]
108800971  [KO:K04870]
108800972  CACNG4; voltage-dependent calcium channel gamma-4 subunit [KO:K04869]
108800973  CACNG1; voltage-dependent calcium channel gamma-1 subunit [KO:K04866]
108801054  RRAS2; ras-related protein R-Ras2 [KO:K07830]
108801239  ELK1; ETS domain-containing protein Elk-1 isoform X1 [KO:K04375]
108801341  [KO:K12457]
108801347  ARAF; serine/threonine-protein kinase A-Raf [KO:K08845] [EC:2.7.11.1]
108801499  MAP2K4; dual specificity mitogen-activated protein kinase kinase 4 isoform X1 [KO:K04430] [EC:2.7.12.2]
108801502  [KO:K04439]
108801545  MKNK2; MAP kinase-interacting serine/threonine-protein kinase 2 isoform X1 [KO:K04372] [EC:2.7.11.1]
108801671  MAX; protein max isoform X1 [KO:K04453]
108801690  NLK; LOW QUALITY PROTEIN: serine/threonine-protein kinase NLK [KO:K04468] [EC:2.7.11.24]
108801710  CRK; adapter molecule crk isoform X1 [KO:K04438]
108801801  [KO:K04864]
108801947  CACNA2D2; voltage-dependent calcium channel subunit alpha-2/delta-2 [KO:K04859]
108802180  NTRK1; high affinity nerve growth factor receptor [KO:K03176] [EC:2.7.10.1]
108802205  [KO:K04871]
108802369  CRKL; crk-like protein isoform X1 [KO:K04438]
108802437  [KO:K04380]
108802481  FOS; proto-oncogene c-Fos [KO:K04379]
108802493  MAP3K3; mitogen-activated protein kinase kinase kinase 3 isoform X1 [KO:K04421] [EC:2.7.11.25]
108802561  EPHA2; ephrin type-A receptor 2 [KO:K05103] [EC:2.7.10.1]
108802795  [KO:K04405]
108802832  [KO:K04444] [EC:2.7.11.1]
108802853  [KO:K04373] [EC:2.7.11.1]
108802996  [KO:K08774]
108803002  [KO:K07827]
108803008  [KO:K04388] [EC:2.7.11.30]
108803130  PPP5C; serine/threonine-protein phosphatase 5 [KO:K04460] [EC:3.1.3.16]
108803804  KIT; mast/stem cell growth factor receptor Kit [KO:K05091] [EC:2.7.10.1]
108803904  KDR; vascular endothelial growth factor receptor 2 [KO:K05098] [EC:2.7.10.1]
108804111  PDGFRA; platelet-derived growth factor receptor alpha isoform X1 [KO:K04363] [EC:2.7.10.1]
108804455  MAPK10; mitogen-activated protein kinase 10 isoform X1 [KO:K04440] [EC:2.7.11.24]
108804561  RAP1B; ras-related protein Rap-1b [KO:K07836]
108804573  PTPRR; receptor-type tyrosine-protein phosphatase R [KO:K04458] [EC:3.1.3.48]
108804591  IL1RAP; interleukin-1 receptor accessory protein [KO:K04723]
108804593  CACNA2D4; voltage-dependent calcium channel subunit alpha-2/delta-4 [KO:K04861]
108804717  [KO:K05466]
108804838  MAPK12; mitogen-activated protein kinase 12 isoform X1 [KO:K04441] [EC:2.7.11.24]
108804839  MAPK11; mitogen-activated protein kinase 11 isoform X1 [KO:K04441] [EC:2.7.11.24]
108804869  CACNA1S; voltage-dependent L-type calcium channel subunit alpha-1S [KO:K04857]
Compound
C00076  Calcium cation
C00165  Diacylglycerol
C00338  Lipopolysaccharide
C00575  3',5'-Cyclic AMP
C01245  D-myo-Inositol 1,4,5-trisphosphate
Reference
PMID:11749383
  Authors
Chen Z, Gibson TB, Robinson F, Silvestro L, Pearson G, Xu B, Wright A, Vanderbilt C, Cobb MH.
  Title
MAP kinases.
  Journal
Chem Rev 101:2449-76 (2001)
DOI:10.1021/cr000241p
Reference
PMID:12191611
  Authors
Tanoue T, Nishida E.
  Title
Docking interactions in the mitogen-activated protein kinase cascades.
  Journal
Pharmacol Ther 93:193-202 (2002)
DOI:10.1016/S0163-7258(02)00188-2
Reference
PMID:12947395
  Authors
Dent P, Yacoub A, Fisher PB, Hagan MP, Grant S.
  Title
MAPK pathways in radiation responses.
  Journal
Oncogene 22:5885-96 (2003)
DOI:10.1038/sj.onc.1206701
Reference
PMID:12676795
  Authors
Huang EJ, Reichardt LF.
  Title
Trk receptors: roles in neuronal signal transduction.
  Journal
Annu Rev Biochem 72:609-42 (2003)
DOI:10.1146/annurev.biochem.72.121801.161629
Reference
PMID:11369511
  Authors
Harper SJ, LoGrasso P.
  Title
Signalling for survival and death in neurones: the role of stress-activated kinases, JNK and p38.
  Journal
Cell Signal 13:299-310 (2001)
DOI:10.1016/S0898-6568(01)00148-6
Reference
PMID:12390245
  Authors
Takeda K, Ichijo H
  Title
Neuronal p38 MAPK signalling: an emerging regulator of cell fate and function in the nervous system.
  Journal
Genes Cells 7:1099-111 (2002)
DOI:10.1046/j.1365-2443.2002.00591.x
Reference
PMID:14597384
  Authors
Yang SH, Sharrocks AD, Whitmarsh AJ.
  Title
Transcriptional regulation by the MAP kinase signaling cascades.
  Journal
Gene 320:3-21 (2003)
DOI:10.1016/S0378-1119(03)00816-3
Reference
PMID:12566928
  Authors
Zhu X, Lee HG, Raina AK, Perry G, Smith MA.
  Title
The role of mitogen-activated protein kinase pathways in Alzheimer's disease.
  Journal
Neurosignals 11:270-81 (2002)
DOI:10.1159/000067426
Reference
PMID:12849693
  Authors
Cho H, Lee J, Kwak NJ, Lee KH, Rha S, Kim YH, Cho YY, Yang KH, Kim K, Lim Y.
  Title
Silica induces nuclear factor-kappaB activation through TAK1 and NIK in Rat2 cell line.
  Journal
Toxicol Lett 143:323-30 (2003)
DOI:10.1016/S0378-4274(03)00193-0
Reference
PMID:20602996
  Authors
Lemmon MA, Schlessinger J
  Title
Cell signaling by receptor tyrosine kinases.
  Journal
Cell 141:1117-34 (2010)
DOI:10.1016/j.cell.2010.06.011
Reference
PMID:22367796
  Authors
Skaper SD
  Title
The neurotrophin family of neurotrophic factors: an overview.
  Journal
Methods Mol Biol 846:1-12 (2012)
DOI:10.1007/978-1-61779-536-7_1
Reference
PMID:23085193
  Authors
Chu WM
  Title
Tumor necrosis factor.
  Journal
Cancer Lett 328:222-5 (2013)
DOI:10.1016/j.canlet.2012.10.014
Reference
PMID:22296764
  Authors
Newton K, Dixit VM
  Title
Signaling in innate immunity and inflammation.
  Journal
Cold Spring Harb Perspect Biol 4:a006049 (2012)
DOI:10.1101/cshperspect.a006049
Reference
PMID:19483709
  Authors
Gaestel M, Kotlyarov A, Kracht M
  Title
Targeting innate immunity protein kinase signalling in inflammation.
  Journal
Nat Rev Drug Discov 8:480-99 (2009)
DOI:10.1038/nrd2829
Reference
PMID:23664135
  Authors
Ajibade AA, Wang HY, Wang RF
  Title
Cell type-specific function of TAK1 in innate immune signaling.
  Journal
Trends Immunol 34:307-16 (2013)
DOI:10.1016/j.it.2013.03.007
Reference
PMID:24892271
  Authors
Turner MD, Nedjai B, Hurst T, Pennington DJ
  Title
Cytokines and chemokines: At the crossroads of cell signalling and inflammatory disease.
  Journal
Biochim Biophys Acta 1843:2563-2582 (2014)
DOI:10.1016/j.bbamcr.2014.05.014
Related
pathway
npr04070  Phosphatidylinositol signaling system
npr04110  Cell cycle
npr04115  p53 signaling pathway
npr04210  Apoptosis
npr04310  Wnt signaling pathway
KO pathway
ko04010   

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