KEGG   PATHWAY: nss05168
Entry
nss05168                    Pathway                                
Name
Herpes simplex virus 1 infection - Notechis scutatus (mainland tiger snake)
Description
Herpes simplex virus 1(HSV-1) is a common human pathogen, which initially infects orofacial mucosal surfaces. The virus replicates in epithelial cells at these sites, causing clinically overt disease characterized by vesicular lesions. HSV-1 then penetrates to the nervous system and establishes latency in sensory neurons. Throughout the lifetime of the host, HSV-1 may reactivate from its latent state and reinitiate a lytic infection cycle. HSV-1 has developed various mechanisms to escape its host innate immune responses and increased its capacity to replicate and to persist. ICP34.5, ICP0, ICP27, Us11 and Vhs (UL41) are the proteins involved in viral interference.
Class
Human Diseases; Infectious disease: viral
Pathway map
nss05168  Herpes simplex virus 1 infection
nss05168

Disease
H00365  Herpes simplex virus infection
Organism
Notechis scutatus (mainland tiger snake) [GN:nss]
Gene
113409751  PIK3CB; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform [KO:K00922] [EC:2.7.1.153]
113409758  [KO:K05130]
113409814  POU2F1; POU domain, class 2, transcription factor 1 isoform X1 [KO:K09364]
113410038  EIF2B2; translation initiation factor eIF-2B subunit beta [KO:K03754]
113410076  NFKBIA; NF-kappa-B inhibitor alpha [KO:K04734]
113410121  EIF2AK4; eIF-2-alpha kinase GCN2 isoform X1 [KO:K16196] [EC:2.7.11.1]
113410230  TRAF6; TNF receptor-associated factor 6 [KO:K03175] [EC:2.3.2.27]
113410258  FADD; FAS-associated death domain protein [KO:K02373]
113410464  SRC; proto-oncogene tyrosine-protein kinase Src isoform X1 [KO:K05704] [EC:2.7.10.2]
113410870  PPP1CA; serine/threonine-protein phosphatase PP1-alpha catalytic subunit [KO:K06269] [EC:3.1.3.16]
113410968  EIF2B3; translation initiation factor eIF-2B subunit gamma isoform X1 [KO:K03241]
113410978  [KO:K02649]
113411014  [KO:K08057]
113411084  JAK1; tyrosine-protein kinase JAK1 [KO:K11217] [EC:2.7.10.2]
113411209  IFNGR1; interferon gamma receptor 1 [KO:K05132]
113411242  TAB2; TGF-beta-activated kinase 1 and MAP3K7-binding protein 2 [KO:K04404]
113411493  MAP3K7; mitogen-activated protein kinase kinase kinase 7 isoform X1 [KO:K04427] [EC:2.7.11.25]
113411541  PIK3CA; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform [KO:K00922] [EC:2.7.1.153]
113411843  TLR3; toll-like receptor 3 isoform X1 [KO:K05401]
113411860  CASP3; caspase-3 [KO:K02187] [EC:3.4.22.56]
113411977  SOCS3; suppressor of cytokine signaling 3 [KO:K04696]
113411996  ALYREF; THO complex subunit 4 isoform X1 [KO:K12881]
113412111  SRSF2; serine/arginine-rich splicing factor 2 [KO:K12891]
113412210  IFNG; interferon gamma [KO:K04687]
113412281  TBK1; serine/threonine-protein kinase TBK1 isoform X1 [KO:K05410] [EC:2.7.11.10]
113412310  IRAK4; interleukin-1 receptor-associated kinase 4 isoform X1 [KO:K04733] [EC:2.7.11.1]
113412400  STAT1; signal transducer and activator of transcription 1-alpha/beta [KO:K11220]
113412454  [KO:K08738]
113412511  IRF7; interferon regulatory factor 7 isoform X1 [KO:K09447]
113413171  RNASEL; 2-5A-dependent ribonuclease [KO:K01165]
113413243  EIF2AK2; interferon-induced, double-stranded RNA-activated protein kinase [KO:K16195] [EC:2.7.11.1]
113413278  AKT3; RAC-gamma serine/threonine-protein kinase isoform X1 [KO:K04456] [EC:2.7.11.1]
113413424  IRF3; interferon regulatory factor 3 isoform X1 [KO:K05411]
113413668  AKT1; RAC-alpha serine/threonine-protein kinase [KO:K04456] [EC:2.7.11.1]
113413935  PIK3R1; phosphatidylinositol 3-kinase regulatory subunit alpha isoform X1 [KO:K02649]
113414086  CALR3; calreticulin-3 [KO:K08057]
113414090  PIK3R2; phosphatidylinositol 3-kinase regulatory subunit beta [KO:K02649]
113414294  SRSF5; serine/arginine-rich splicing factor 5 [KO:K12893]
113414308  [KO:K12893]
113414323  EIF2S1; eukaryotic translation initiation factor 2 subunit 1 [KO:K03237]
113414444  EIF4EBP1; eukaryotic translation initiation factor 4E-binding protein 1 [KO:K07205]
113414557  [KO:K12499]
113414626  EIF2B4; translation initiation factor eIF-2B subunit delta [KO:K03680]
113414958  TRADD; tumor necrosis factor receptor type 1-associated DEATH domain protein [KO:K03171]
113415036  DDX58; probable ATP-dependent RNA helicase DDX58 [KO:K12646] [EC:5.6.2.6]
113415345  NFKB1; nuclear factor NF-kappa-B p105 subunit [KO:K02580]
113415983  [KO:K08738]
113416112  ITGA5; integrin alpha-5 [KO:K06484]
113416281  SYK; tyrosine-protein kinase SYK [KO:K05855] [EC:2.7.10.2]
113416479  [KO:K12647] [EC:5.6.2.6]
113416534  [KO:K12647] [EC:5.6.2.6]
113417136  BCL2; apoptosis regulator Bcl-2 isoform X1 [KO:K02161]
113417192  [KO:K03158]
113417299  [KO:K16060]
113417429  [KO:K04447] [EC:2.7.10.2]
113417649  SRSF4; serine/arginine-rich splicing factor 4 [KO:K12893]
113417663  IKBKG; NF-kappa-B essential modulator isoform X1 [KO:K07210]
113417693  IRAK1; interleukin-1 receptor-associated kinase 1 [KO:K04730] [EC:2.7.11.1]
113417696  HCFC1; host cell factor 1 isoform X1 [KO:K14966]
113417952  TLR2; toll-like receptor 2 isoform X1 [KO:K10159]
113418517  [KO:K04696]
113418550  BAX; apoptosis regulator BAX [KO:K02159]
113418615  [KO:K02159]
113418757  [KO:K14021]
113418766  [KO:K12892]
113418782  [KO:K15409] [EC:2.7.11.1]
113418902  IL6; interleukin-6 [KO:K05405]
113418975  [KO:K15409] [EC:2.7.11.1]
113418991  [KO:K12892]
113419000  [KO:K14021]
113419351  BID; BH3-interacting domain death agonist isoform X1 [KO:K04726]
113419506  MYD88; myeloid differentiation primary response protein MyD88 [KO:K04729]
113419521  RHEB; GTP-binding protein Rheb isoform X1 [KO:K07208]
113419719  [KO:K28004]
113419937  CALR; calreticulin [KO:K08057]
113420096  EIF2AK3; eukaryotic translation initiation factor 2-alpha kinase 3 isoform X1 [KO:K08860] [EC:2.7.11.1]
113420192  STAT2; signal transducer and activator of transcription 2 isoform X1 [KO:K11221]
113420338  TRAF3; TNF receptor-associated factor 3 isoform X1 [KO:K03174]
113420402  [KO:K05414]
113420511  SRSF1; serine/arginine-rich splicing factor 1 isoform X1 [KO:K12890]
113421267  [KO:K07293] [EC:3.1.3.48]
113421356  PPP1CB; serine/threonine-protein phosphatase PP1-beta catalytic subunit isoform X1 [KO:K06269] [EC:3.1.3.16]
113421451  FASLG; tumor necrosis factor ligand superfamily member 6 [KO:K04389]
113421509  NECTIN1; nectin-1 [KO:K06081]
113421517  POU2F3; POU domain, class 2, transcription factor 3 [KO:K09364]
113421555  TNFSF14; tumor necrosis factor ligand superfamily member 14 [KO:K05477]
113421842  SRSF6; serine/arginine-rich splicing factor 6 [KO:K12893]
113422071  ITGB3; integrin beta-3 [KO:K06493]
113422230  TRAF5; TNF receptor-associated factor 5 [KO:K09849]
113422575  TSC2; tuberin [KO:K07207]
113422897  B2M; beta-2-microglobulin isoform X1 [KO:K08055]
113422955  CFP; properdin [KO:K15412]
113423133  MTOR; serine/threonine-protein kinase mTOR [KO:K07203] [EC:2.7.11.1]
113423215  PML; protein PML isoform X1 [KO:K10054] [EC:2.3.2.-]
113423236  [KO:K10054] [EC:2.3.2.-]
113423321  PDIA3; protein disulfide-isomerase A3 [KO:K08056] [EC:5.3.4.1]
113423381  IL1B; interleukin-1 beta [KO:K04519]
113423754  [KO:K05425]
113423982  CASP9; caspase-9 isoform X1 [KO:K04399] [EC:3.4.22.62]
113424253  TRAF2; TNF receptor-associated factor 2 [KO:K03173] [EC:2.3.2.27]
113424483  CD74; HLA class II histocompatibility antigen gamma chain [KO:K06505]
113424585  TNF; tumor necrosis factor [KO:K03156]
113424646  PIK3CD; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform [KO:K00922] [EC:2.7.1.153]
113424665  [KO:K10159]
113424789  C5; complement C5 [KO:K03994]
113424903  PPP1CC; serine/threonine-protein phosphatase PP1-gamma catalytic subunit isoform X1 [KO:K06269] [EC:3.1.3.16]
113425020  EIF2B1; translation initiation factor eIF-2B subunit alpha [KO:K03239]
113425161  FAS; tumor necrosis factor receptor superfamily member 6 [KO:K04390]
113425188  CHUK; inhibitor of nuclear factor kappa-B kinase subunit alpha [KO:K04467] [EC:2.7.11.10]
113425248  TSC1; hamartin isoform X1 [KO:K07206]
113425270  EIF2AK1; eukaryotic translation initiation factor 2-alpha kinase 1 [KO:K16194] [EC:2.7.11.1]
113425569  [KO:K04456] [EC:2.7.11.1]
113425762  [KO:K14216] [EC:2.7.7.84]
113425847  SRSF9; serine/arginine-rich splicing factor 9 [KO:K21123]
113425860  TNFRSF14; tumor necrosis factor receptor superfamily member 14 [KO:K05152]
113425931  TICAM1; TIR domain-containing adapter molecule 1 [KO:K05842]
113425983  TAP1; antigen peptide transporter 1 [KO:K05653] [EC:7.4.2.14]
113425984  TAP2; antigen peptide transporter 2 [KO:K05654] [EC:7.4.2.14]
113426227  EIF2B5; translation initiation factor eIF-2B subunit epsilon [KO:K03240]
113426333  NXF1; nuclear RNA export factor 1 [KO:K14284]
113426532  TYK2; non-receptor tyrosine-protein kinase TYK2 isoform X1 [KO:K11219] [EC:2.7.10.2]
113426544  [KO:K06751]
113426547  [KO:K06751]
113426790  PTPN11; tyrosine-protein phosphatase non-receptor type 11 isoform X1 [KO:K07293] [EC:3.1.3.48]
113427196  [KO:K06751]
113427402  CARD9; caspase recruitment domain-containing protein 9 [KO:K12794]
113427675  IKBKB; LOW QUALITY PROTEIN: inhibitor of nuclear factor kappa-B kinase subunit beta [KO:K07209] [EC:2.7.11.10]
113427748  [KO:K06531]
113427757  [KO:K06531]
113427879  [KO:K04451]
113428287  [KO:K06752]
113428414  [KO:K06752]
113428434  [KO:K06751]
113428451  [KO:K06752]
113428666  [KO:K06751]
113429183  [KO:K06752]
113429214  [KO:K12499]
113429219  [KO:K12499]
113429688  [KO:K06752]
113429705  [KO:K06752]
113429826  BAD; bcl2-associated agonist of cell death [KO:K02158]
113429888  [KO:K06752]
113429913  [KO:K06751]
113429941  [KO:K06751]
113430265  [KO:K09364]
113430413  [KO:K05414]
113430433  [KO:K05414]
113430434  [KO:K05414]
113430553  [KO:K05414]
113430715  DAXX; death domain-associated protein 6 [KO:K02308]
113430783  [KO:K06751]
113430792  [KO:K06752]
113430880  [KO:K06752]
113430968  [KO:K06752]
113431028  [KO:K06752]
113431455  [KO:K06752]
113431457  BCL2L1; bcl-2-like protein 1 [KO:K04570]
113431564  SRSF7; serine/arginine-rich splicing factor 7 [KO:K12896]
113431609  [KO:K06752]
113431849  APAF1; apoptotic protease-activating factor 1 [KO:K02084]
113432099  [KO:K06752]
113432232  [KO:K06752]
113432298  [KO:K06752]
113432357  [KO:K06752]
113432426  [KO:K06752]
113432584  [KO:K06752]
113432712  TAB1; TGF-beta-activated kinase 1 and MAP3K7-binding protein 1 [KO:K04403]
113432804  HCFC2; host cell factor 2 isoform X1 [KO:K27390]
Compound
C05981  Phosphatidylinositol-3,4,5-trisphosphate
C20640  Cyclic GMP-AMP
C20935  2-5A
Reference
PMID:12787566
  Authors
Granger SW, Rickert S
  Title
LIGHT-HVEM signaling and the regulation of T cell-mediated immunity.
  Journal
Cytokine Growth Factor Rev 14:289-96 (2003)
DOI:10.1016/S1359-6101(03)00031-5
Reference
PMID:19495760
  Authors
Steinberg MW, Shui JW, Ware CF, Kronenberg M
  Title
Regulating the mucosal immune system: the contrasting roles of LIGHT, HVEM, and their various partners.
  Journal
Semin Immunopathol 31:207-21 (2009)
DOI:10.1007/s00281-009-0157-4
Reference
PMID:20221426
  Authors
MacLeod IJ, Minson T
  Title
Binding of herpes simplex virus type-1 virions leads to the induction of intracellular signalling in the absence of virus entry.
  Journal
PLoS One 5:e9560 (2010)
DOI:10.1371/journal.pone.0009560
Reference
PMID:23150579
  Authors
Gianni T, Leoni V, Chesnokova LS, Hutt-Fletcher LM, Campadelli-Fiume G
  Title
alphavbeta3-integrin is a major sensor and activator of innate immunity to herpes simplex virus-1.
  Journal
Proc Natl Acad Sci U S A 109:19792-7 (2012)
DOI:10.1073/pnas.1212597109
Reference
PMID:25375272
  Authors
Gianni T, Campadelli-Fiume G
  Title
The epithelial alphavbeta3-integrin boosts the MYD88-dependent TLR2 signaling in response to viral and bacterial components.
  Journal
PLoS Pathog 10:e1004477 (2014)
DOI:10.1371/journal.ppat.1004477
Reference
PMID:15056211
  Authors
Spear PG
  Title
Herpes simplex virus: receptors and ligands for cell entry.
  Journal
Cell Microbiol 6:401-10 (2004)
DOI:10.1111/j.1462-5822.2004.00389.x
Reference
PMID:12855695
  Authors
Boutell C, Everett RD
  Title
The herpes simplex virus type 1 (HSV-1) regulatory protein ICP0 interacts with and Ubiquitinates p53.
  Journal
J Biol Chem 278:36596-602 (2003)
DOI:10.1074/jbc.M300776200
Reference
PMID:24262390
  Authors
Ma Y, He B
  Title
Recognition of herpes simplex viruses: toll-like receptors and beyond.
  Journal
J Mol Biol 426:1133-47 (2014)
DOI:10.1016/j.jmb.2013.11.012
Reference
PMID:26952111
  Authors
Su C, Zhan G, Zheng C
  Title
Evasion of host antiviral innate immunity by HSV-1, an update.
  Journal
Virol J 13:38 (2016)
DOI:10.1186/s12985-016-0495-5
Reference
PMID:21994567
  Authors
Melchjorsen J, Matikainen S, Paludan SR
  Title
Activation and evasion of innate antiviral immunity by herpes simplex virus.
  Journal
Viruses 1:737-59 (2009)
DOI:10.3390/v1030737
Reference
PMID:15276609
  Authors
Morrison LA
  Title
The Toll of herpes simplex virus infection.
  Journal
Trends Microbiol 12:353-6 (2004)
DOI:10.1016/j.tim.2004.06.001
Reference
PMID:29298887
  Authors
Zheng C
  Title
Evasion of Cytosolic DNA-Stimulated Innate Immune Responses by Herpes Simplex Virus 1.
  Journal
J Virol 92:e00099-17 (2018)
DOI:10.1128/JVI.00099-17
Reference
PMID:19344302
  Authors
Grandi P, Peruzzi P, Reinhart B, Cohen JB, Chiocca EA, Glorioso JC
  Title
Design and application of oncolytic HSV vectors for glioblastoma therapy.
  Journal
Expert Rev Neurother 9:505-17 (2009)
DOI:10.1586/ern.09.9
Reference
PMID:23115300
  Authors
Lussignol M, Queval C, Bernet-Camard MF, Cotte-Laffitte J, Beau I, Codogno P, Esclatine A
  Title
The herpes simplex virus 1 Us11 protein inhibits autophagy through its interaction with the protein kinase PKR.
  Journal
J Virol 87:859-71 (2013)
DOI:10.1128/JVI.01158-12
Reference
PMID:17229694
  Authors
Sanchez R, Mohr I
  Title
Inhibition of cellular 2'-5' oligoadenylate synthetase by the herpes simplex virus type 1 Us11 protein.
  Journal
J Virol 81:3455-64 (2007)
DOI:10.1128/JVI.02520-06
Reference
PMID:12826401
  Authors
Wysocka J, Herr W
  Title
The herpes simplex virus VP16-induced complex: the makings of a regulatory switch.
  Journal
Trends Biochem Sci 28:294-304 (2003)
DOI:10.1016/S0968-0004(03)00088-4
Reference
PMID:27367734
  Authors
Fleming SB
  Title
Viral Inhibition of the IFN-Induced JAK/STAT Signalling Pathway: Development of Live Attenuated Vaccines by Mutation of Viral-Encoded IFN-Antagonists.
  Journal
Vaccines (Basel) 4:E23 (2016)
DOI:10.3390/vaccines4030023
Reference
PMID:15163721
  Authors
Yokota S, Yokosawa N, Okabayashi T, Suzutani T, Miura S, Jimbow K, Fujii N
  Title
Induction of suppressor of cytokine signaling-3 by herpes simplex virus type 1 contributes to inhibition of the interferon signaling pathway.
  Journal
J Virol 78:6282-6 (2004)
DOI:10.1128/JVI.78.12.6282-6286.2004
Reference
PMID:23864622
  Authors
Gu H, Zheng Y, Roizman B
  Title
Interaction of herpes simplex virus ICP0 with ND10 bodies: a sequential process of adhesion, fusion, and retention.
  Journal
J Virol 87:10244-54 (2013)
DOI:10.1128/JVI.01487-13
Reference
PMID:21994592
  Authors
Tavalai N, Stamminger T
  Title
Interplay between Herpesvirus Infection and Host Defense by PML Nuclear Bodies.
  Journal
Viruses 1:1240-64 (2009)
DOI:10.3390/v1031240
Reference
PMID:21146386
  Authors
Horst D, Verweij MC, Davison AJ, Ressing ME, Wiertz EJ
  Title
Viral evasion of T cell immunity: ancient mechanisms offering new applications.
  Journal
Curr Opin Immunol 23:96-103 (2011)
DOI:10.1016/j.coi.2010.11.005
Reference
PMID:12960333
  Authors
Neumann J, Eis-Hubinger AM, Koch N
  Title
Herpes simplex virus type 1 targets the MHC class II processing pathway for immune evasion.
  Journal
J Immunol 171:3075-83 (2003)
DOI:10.4049/jimmunol.171.6.3075
Reference
PMID:25798530
  Authors
Liu X, Cohen JI
  Title
The role of PI3K/Akt in human herpesvirus infection: From the bench to the bedside.
  Journal
Virology 479-480:568-77 (2015)
DOI:10.1016/j.virol.2015.02.040
Reference
PMID:28468873
  Authors
Vink EI, Smiley JR, Mohr I
  Title
Subversion of Host Responses to Energy Insufficiency by Us3 Supports Herpes Simplex Virus 1 Replication during Stress.
  Journal
J Virol 91:e00295-17 (2017)
DOI:10.1128/JVI.00295-17
Reference
PMID:18508584
  Authors
Sandri-Goldin RM
  Title
The many roles of the regulatory protein ICP27 during herpes simplex virus infection.
  Journal
Front Biosci 13:5241-56 (2008)
DOI:10.2741/3078
Reference
PMID:15078920
  Authors
Sandri-Goldin RM
  Title
Viral regulation of mRNA export.
  Journal
J Virol 78:4389-96 (2004)
DOI:10.1128/JVI.78.9.4389-4396.2004
Reference
PMID:27154074
  Authors
Yu X, He S
  Title
The interplay between human herpes simplex virus infection and the apoptosis and necroptosis cell death pathways.
  Journal
Virol J 13:77 (2016)
DOI:10.1186/s12985-016-0528-0
Related
pathway
nss03040  Spliceosome
nss03050  Proteasome
nss04115  p53 signaling pathway
nss04210  Apoptosis
nss04620  Toll-like receptor signaling pathway
nss04622  RIG-I-like receptor signaling pathway
KO pathway
ko05168   

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