Entry
Name
Herpes simplex virus 1 infection - Notechis scutatus (mainland tiger snake)
Description
Herpes simplex virus 1(HSV-1) is a common human pathogen, which initially infects orofacial mucosal surfaces. The virus replicates in epithelial cells at these sites, causing clinically overt disease characterized by vesicular lesions. HSV-1 then penetrates to the nervous system and establishes latency in sensory neurons. Throughout the lifetime of the host, HSV-1 may reactivate from its latent state and reinitiate a lytic infection cycle. HSV-1 has developed various mechanisms to escape its host innate immune responses and increased its capacity to replicate and to persist. ICP34.5, ICP0, ICP27, Us11 and Vhs (UL41) are the proteins involved in viral interference.
Class
Human Diseases; Infectious disease: viral
BRITE hierarchy
Pathway map
nss05168 Herpes simplex virus 1 infection
Ortholog table
Organism
Notechis scutatus (mainland tiger snake) [GN:
nss ]
Gene
113421555 TNFSF14; tumor necrosis factor ligand superfamily member 14 [KO:K05477 ]
113425860 TNFRSF14; tumor necrosis factor receptor superfamily member 14 [KO:K05152 ]
113427675 IKBKB; LOW QUALITY PROTEIN: inhibitor of nuclear factor kappa-B kinase subunit beta [KO:K07209 ] [EC:2.7.11.10 ]
113427402 CARD9; caspase recruitment domain-containing protein 9 [KO:K12794 ]
113419506 MYD88; myeloid differentiation primary response protein MyD88 [KO:K04729 ]
113432712 TAB1; TGF-beta-activated kinase 1 and MAP3K7-binding protein 1 [KO:K04403 ]
113411242 TAB2; TGF-beta-activated kinase 1 and MAP3K7-binding protein 2 [KO:K04404 ]
113424903 PPP1CC; serine/threonine-protein phosphatase PP1-gamma catalytic subunit isoform X1 [KO:K06269 ] [EC:3.1.3.16 ]
113421356 PPP1CB; serine/threonine-protein phosphatase PP1-beta catalytic subunit isoform X1 [KO:K06269 ] [EC:3.1.3.16 ]
113414323 EIF2S1; eukaryotic translation initiation factor 2 subunit 1 [KO:K03237 ]
113425020 EIF2B1; translation initiation factor eIF-2B subunit alpha [KO:K03239 ]
113410038 EIF2B2; translation initiation factor eIF-2B subunit beta [KO:K03754 ]
113410968 EIF2B3; translation initiation factor eIF-2B subunit gamma isoform X1 [KO:K03241 ]
113414626 EIF2B4; translation initiation factor eIF-2B subunit delta [KO:K03680 ]
113426227 EIF2B5; translation initiation factor eIF-2B subunit epsilon [KO:K03240 ]
113409814 POU2F1; POU domain, class 2, transcription factor 1 isoform X1 [KO:K09364 ]
113412400 STAT1; signal transducer and activator of transcription 1-alpha/beta [KO:K11220 ]
113420192 STAT2; signal transducer and activator of transcription 2 isoform X1 [KO:K11221 ]
113427232 zinc finger and SCAN domain-containing protein 2-like [KO:K09228 ]
113423562 gastrula zinc finger protein XlCGF57.1-like isoform X1 [KO:K09228 ]
113426544 class I histocompatibility antigen, F10 alpha chain-like [KO:K06751 ]
113426547 class I histocompatibility antigen, F10 alpha chain-like isoform X1 [KO:K06751 ]
113427196 class I histocompatibility antigen, F10 alpha chain-like [KO:K06751 ]
113428434 H-2 class I histocompatibility antigen, Q9 alpha chain-like [KO:K06751 ]
113428666 class I histocompatibility antigen, F10 alpha chain-like [KO:K06751 ]
113429913 H-2 class I histocompatibility antigen, Q9 alpha chain-like [KO:K06751 ]
113429941 class I histocompatibility antigen, F10 alpha chain-like isoform X1 [KO:K06751 ]
113430783 RT1 class I histocompatibility antigen, AA alpha chain-like [KO:K06751 ]
113428287 H-2 class II histocompatibility antigen, E-S beta chain-like isoform X1 [KO:K06752 ]
113428451 H-2 class II histocompatibility antigen, E-S beta chain-like [KO:K06752 ]
113429183 H-2 class II histocompatibility antigen, E-S beta chain-like [KO:K06752 ]
113429688 mamu class II histocompatibility antigen, DR alpha chain [KO:K06752 ]
113429705 rano class II histocompatibility antigen, A beta chain-like [KO:K06752 ]
113429888 DLA class II histocompatibility antigen, DR-1 beta chain-like [KO:K06752 ]
113430792 rano class II histocompatibility antigen, A beta chain-like [KO:K06752 ]
113430880 DLA class II histocompatibility antigen, DR-1 beta chain-like isoform X1 [KO:K06752 ]
113430968 rano class II histocompatibility antigen, A beta chain-like [KO:K06752 ]
113431028 H-2 class II histocompatibility antigen, I-E beta chain-like [KO:K06752 ]
113431455 rano class II histocompatibility antigen, A beta chain-like [KO:K06752 ]
113431609 H-2 class II histocompatibility antigen, E-S beta chain-like [KO:K06752 ]
113432099 rano class II histocompatibility antigen, A beta chain-like [KO:K06752 ]
113432232 HLA class II histocompatibility antigen, DM beta chain [KO:K06752 ]
113432298 rano class II histocompatibility antigen, A beta chain-like [KO:K06752 ]
113432357 rano class II histocompatibility antigen, A beta chain-like [KO:K06752 ]
113432426 rano class II histocompatibility antigen, A beta chain-like [KO:K06752 ]
113432584 rano class II histocompatibility antigen, A beta chain-like [KO:K06752 ]
113424483 CD74; HLA class II histocompatibility antigen gamma chain [KO:K06505 ]
113424646 PIK3CD; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform [KO:K00922 ] [EC:2.7.1.153 ]
113409751 PIK3CB; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform [KO:K00922 ] [EC:2.7.1.153 ]
113411541 PIK3CA; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform [KO:K00922 ] [EC:2.7.1.153 ]
113413935 PIK3R1; phosphatidylinositol 3-kinase regulatory subunit alpha isoform X1 [KO:K02649 ]
113414090 PIK3R2; phosphatidylinositol 3-kinase regulatory subunit beta [KO:K02649 ]
113410978 phosphatidylinositol 3-kinase regulatory subunit gamma [KO:K02649 ]
113414444 EIF4EBP1; eukaryotic translation initiation factor 4E-binding protein 1 [KO:K07205 ]
113420511 SRSF1; serine/arginine-rich splicing factor 1 isoform X1 [KO:K12890 ]
113421451 FASLG; tumor necrosis factor ligand superfamily member 6 [KO:K04389 ]
113425161 FAS; tumor necrosis factor receptor superfamily member 6 [KO:K04390 ]
113417192 tumor necrosis factor receptor superfamily member 1A-like [KO:K03158 ]
113414958 TRADD; tumor necrosis factor receptor type 1-associated DEATH domain protein [KO:K03171 ]
Compound
C05981 Phosphatidylinositol-3,4,5-trisphosphate
Reference
Authors
Granger SW, Rickert S
Title
LIGHT-HVEM signaling and the regulation of T cell-mediated immunity.
Journal
Reference
Authors
Steinberg MW, Shui JW, Ware CF, Kronenberg M
Title
Regulating the mucosal immune system: the contrasting roles of LIGHT, HVEM, and their various partners.
Journal
Reference
Authors
MacLeod IJ, Minson T
Title
Binding of herpes simplex virus type-1 virions leads to the induction of intracellular signalling in the absence of virus entry.
Journal
Reference
Authors
Gianni T, Leoni V, Chesnokova LS, Hutt-Fletcher LM, Campadelli-Fiume G
Title
alphavbeta3-integrin is a major sensor and activator of innate immunity to herpes simplex virus-1.
Journal
Reference
Authors
Gianni T, Campadelli-Fiume G
Title
The epithelial alphavbeta3-integrin boosts the MYD88-dependent TLR2 signaling in response to viral and bacterial components.
Journal
Reference
Authors
Spear PG
Title
Herpes simplex virus: receptors and ligands for cell entry.
Journal
Reference
Authors
Boutell C, Everett RD
Title
The herpes simplex virus type 1 (HSV-1) regulatory protein ICP0 interacts with and Ubiquitinates p53.
Journal
Reference
Authors
Ma Y, He B
Title
Recognition of herpes simplex viruses: toll-like receptors and beyond.
Journal
Reference
Authors
Su C, Zhan G, Zheng C
Title
Evasion of host antiviral innate immunity by HSV-1, an update.
Journal
Reference
Authors
Melchjorsen J, Matikainen S, Paludan SR
Title
Activation and evasion of innate antiviral immunity by herpes simplex virus.
Journal
Reference
Authors
Morrison LA
Title
The Toll of herpes simplex virus infection.
Journal
Reference
Authors
Zheng C
Title
Evasion of Cytosolic DNA-Stimulated Innate Immune Responses by Herpes Simplex Virus 1.
Journal
Reference
Authors
Grandi P, Peruzzi P, Reinhart B, Cohen JB, Chiocca EA, Glorioso JC
Title
Design and application of oncolytic HSV vectors for glioblastoma therapy.
Journal
Reference
Authors
Lussignol M, Queval C, Bernet-Camard MF, Cotte-Laffitte J, Beau I, Codogno P, Esclatine A
Title
The herpes simplex virus 1 Us11 protein inhibits autophagy through its interaction with the protein kinase PKR.
Journal
Reference
Authors
Sanchez R, Mohr I
Title
Inhibition of cellular 2'-5' oligoadenylate synthetase by the herpes simplex virus type 1 Us11 protein.
Journal
Reference
Authors
Wysocka J, Herr W
Title
The herpes simplex virus VP16-induced complex: the makings of a regulatory switch.
Journal
Reference
Authors
Fleming SB
Title
Viral Inhibition of the IFN-Induced JAK/STAT Signalling Pathway: Development of Live Attenuated Vaccines by Mutation of Viral-Encoded IFN-Antagonists.
Journal
Reference
Authors
Yokota S, Yokosawa N, Okabayashi T, Suzutani T, Miura S, Jimbow K, Fujii N
Title
Induction of suppressor of cytokine signaling-3 by herpes simplex virus type 1 contributes to inhibition of the interferon signaling pathway.
Journal
Reference
Authors
Gu H, Zheng Y, Roizman B
Title
Interaction of herpes simplex virus ICP0 with ND10 bodies: a sequential process of adhesion, fusion, and retention.
Journal
Reference
Authors
Tavalai N, Stamminger T
Title
Interplay between Herpesvirus Infection and Host Defense by PML Nuclear Bodies.
Journal
Reference
Authors
Horst D, Verweij MC, Davison AJ, Ressing ME, Wiertz EJ
Title
Viral evasion of T cell immunity: ancient mechanisms offering new applications.
Journal
Reference
Authors
Neumann J, Eis-Hubinger AM, Koch N
Title
Herpes simplex virus type 1 targets the MHC class II processing pathway for immune evasion.
Journal
Reference
Authors
Liu X, Cohen JI
Title
The role of PI3K/Akt in human herpesvirus infection: From the bench to the bedside.
Journal
Reference
Authors
Vink EI, Smiley JR, Mohr I
Title
Subversion of Host Responses to Energy Insufficiency by Us3 Supports Herpes Simplex Virus 1 Replication during Stress.
Journal
Reference
Authors
Sandri-Goldin RM
Title
The many roles of the regulatory protein ICP27 during herpes simplex virus infection.
Journal
Reference
Authors
Sandri-Goldin RM
Title
Viral regulation of mRNA export.
Journal
Reference
Authors
Yu X, He S
Title
The interplay between human herpes simplex virus infection and the apoptosis and necroptosis cell death pathways.
Journal
Related pathway
nss04620 Toll-like receptor signaling pathway
nss04622 RIG-I-like receptor signaling pathway
KO pathway
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