KEGG   PATHWAY: pki04510
Entry
pki04510                    Pathway                                
Name
Focal adhesion - Paramormyrops kingsleyae
Description
Cell-matrix adhesions play essential roles in important biological processes including cell motility, cell proliferation, cell differentiation, regulation of gene expression and cell survival. At the cell-extracellular matrix contact points, specialized structures are formed and termed focal adhesions, where bundles of actin filaments are anchored to transmembrane receptors of the integrin family through a multi-molecular complex of junctional plaque proteins. Some of the constituents of focal adhesions participate in the structural link between membrane receptors and the actin cytoskeleton, while others are signalling molecules, including different protein kinases and phosphatases, their substrates, and various adapter proteins. Integrin signaling is dependent upon the non-receptor tyrosine kinase activities of the FAK and src proteins as well as the adaptor protein functions of FAK, src and Shc to initiate downstream signaling events. These signalling events culminate in reorganization of the actin cytoskeleton; a prerequisite for changes in cell shape and motility, and gene expression. Similar morphological alterations and modulation of gene expression are initiated by the binding of growth factors to their respective receptors, emphasizing the considerable crosstalk between adhesion- and growth factor-mediated signalling.
Class
Cellular Processes; Cellular community - eukaryotes
Pathway map
pki04510  Focal adhesion
pki04510

Other DBs
GO: 0005925
Organism
Paramormyrops kingsleyae [GN:pki]
Gene
111855986  collagen alpha-1(I) chain-like [KO:K06236]
111843899  col1a2; collagen alpha-2(I) chain isoform X1 [KO:K06236]
111848653  collagen alpha-1(I) chain-like [KO:K06236]
111835252  collagen alpha-1(II) chain isoform X1 [KO:K19719]
111844673  collagen alpha-1(II) chain-like [KO:K19719]
111851213  col4a2; collagen alpha-2(IV) chain isoform X1 [KO:K06237]
111851318  collagen alpha-1(IV) chain-like isoform X1 [KO:K06237]
111836502  collagen alpha-5(IV) chain-like [KO:K06237]
111836503  collagen alpha-6(IV) chain-like isoform X1 [KO:K06237]
111836661  collagen alpha-5(IV) chain-like isoform X1 [KO:K06237]
111836662  collagen alpha-4(IV) chain-like isoform X1 [KO:K06237]
111846315  collagen alpha-5(IV) chain-like isoform X1 [KO:K06237]
111846316  collagen alpha-6(IV) chain-like isoform X1 [KO:K06237]
111836027  collagen alpha-4(IV) chain-like isoform X1 [KO:K06237]
111836030  collagen alpha-5(IV) chain-like [KO:K06237]
111843663  collagen alpha-1(IV) chain-like isoform X1 [KO:K06237]
111858313  col6a2; collagen alpha-2(VI) chain isoform X1 [KO:K06238]
111858349  col6a1; collagen alpha-1(VI) chain [KO:K06238]
111857822  collagen alpha-6(VI) chain-like isoform X1 [KO:K06238]
111857834  collagen alpha-4(VI) chain-like [KO:K06238]
111850193  col6a3; collagen alpha-3(VI) chain isoform X1 [KO:K06238]
111855062  col9a1; collagen alpha-1(IX) chain [KO:K08131]
111857360  col9a3; collagen alpha-3(IX) chain [KO:K08131]
111854264  col9a2; collagen alpha-2(IX) chain isoform X1 [KO:K08131]
111843873  collagen alpha-3(IX) chain-like isoform X1 [KO:K08131]
111850756  collagen alpha-1(IX) chain-like isoform X1 [KO:K08131]
111844329  collagen alpha-2(XI) chain-like [KO:K08131]
111850071  laminin subunit alpha-1-like isoform X1 [KO:K05637]
111836135  lama2; laminin subunit alpha-2 isoform X1 [KO:K05637]
111849741  lama1; laminin subunit alpha-1 isoform X1 [KO:K05637]
111845899  lama3; laminin subunit alpha-3 isoform X1 [KO:K06240]
111855339  lama5; laminin subunit alpha-5 [KO:K06240]
111843020  lama4; laminin subunit alpha-4 isoform X1 [KO:K06241]
111857762  laminin subunit beta-1-like [KO:K05636]
111853394  laminin subunit beta-1-like isoform X1 [KO:K05636]
111851173  laminin subunit beta-2-like isoform X1 [KO:K06243]
111851187  laminin subunit beta-2-like [KO:K06243]
111858912  lamb3; laminin subunit beta-3 isoform X1 [KO:K06244]
111853392  laminin subunit beta-4-like [KO:K06245]
111847551  lamc1; laminin subunit gamma-1 [KO:K05635]
111847670  laminin subunit gamma-2-like [KO:K06246]
111841866  lamc3; laminin subunit gamma-3 isoform X1 [KO:K06247]
111834649  chad; chondroadherin [KO:K06248]
111851229  reln; reelin isoform X1 [KO:K06249] [EC:3.4.21.-]
111857554  reelin-like [KO:K06249] [EC:3.4.21.-]
111838851  thbs1; thrombospondin-1 isoform X1 [KO:K16857]
111858158  thrombospondin-2-like [KO:K04659]
111838462  thbs3; thrombospondin-3 isoform X1 [KO:K04659]
111832790  thrombospondin-3a-like [KO:K04659]
111853425  thbs2; thrombospondin-2 isoform X1 [KO:K04659]
111849784  thbs4; thrombospondin-4 [KO:K04659]
111839334  thrombospondin-4-B-like [KO:K04659]
111860169  thrombospondin-4-like [KO:K04659]
111840678  fn1; fibronectin isoform X1 [KO:K05717]
111852935  vitronectin-like [KO:K06251]
111860797  vtn; LOW QUALITY PROTEIN: vitronectin [KO:K06251]
111858725  tenascin-like [KO:K06252]
111842805  tenascin-like isoform X1 [KO:K06252]
111836957  tnr; tenascin-R isoform X1 [KO:K06252]
111839015  tenascin-like [KO:K06252]
111835357  tenascin-like isoform X1 [KO:K06252]
111837788  vwf; von Willebrand factor [KO:K03900]
111849844  itga1; integrin alpha-1 [KO:K06480]
111849840  itga2; integrin alpha-2 [KO:K06481]
111855947  integrin alpha-IIb-like isoform X1 [KO:K06476]
111848633  itga3; integrin alpha-3 isoform X1 [KO:K06482]
111838577  itga4; integrin alpha-4 isoform X1 [KO:K06483]
111851704  itga5; integrin alpha-5 [KO:K06484]
111840820  itga6; integrin alpha-6 isoform X1 [KO:K06485]
111852279  integrin alpha-6-like isoform X1 [KO:K06485]
111835270  itga7; integrin alpha-7 isoform X1 [KO:K06583]
111860654  itga8; integrin alpha-8 [KO:K06584]
111851134  itga9; integrin alpha-9 isoform X1 [KO:K06585]
111840880  itga10; integrin alpha-10 [KO:K06586]
111845616  integrin alpha-11-like [KO:K06587]
111836033  integrin alpha-11-like [KO:K06587]
111838588  itgav; integrin alpha-V isoform X1 [KO:K06487]
111843340  integrin alpha-V-like isoform X1 [KO:K06487]
111858545  itgb1; integrin beta-1 isoform X1 [KO:K05719]
111856058  integrin beta-3-like isoform X1 [KO:K06493]
111856113  itgb3; integrin beta-3 [KO:K06493]
111856701  itgb4; integrin beta-4 isoform X1 [KO:K06525]
111851732  itgb5; integrin beta-5 [KO:K06588]
111834928  itgb6; integrin beta-6 isoform X1 [KO:K06589]
111858768  itgb7; integrin beta-7 isoform X1 [KO:K06590]
111846944  itgb8; integrin beta-8 [KO:K06591]
111849104  emp2; epithelial membrane protein 2 [KO:K26256]
111845546  epithelial membrane protein 2-like [KO:K26256]
111843309  platelet-derived growth factor subunit A-like isoform X1 [KO:K04359]
111860586  platelet-derived growth factor subunit A-like [KO:K04359]
111845270  uncharacterized protein LOC111845270 [KO:K17386]
111846386  platelet-derived growth factor subunit B-like isoform X1 [KO:K17386]
111833654  platelet-derived growth factor C-like isoform X1 [KO:K05450]
111833932  pdgfd; platelet-derived growth factor D [KO:K05450]
111837344  platelet-derived growth factor C-like isoform X1 [KO:K05450]
111849374  egf; pro-epidermal growth factor isoform X1 [KO:K04357]
111834375  insulin-like growth factor I [KO:K05459]
111846569  igf1; LOW QUALITY PROTEIN: insulin-like growth factor I [KO:K05459]
111851553  vegfa; vascular endothelial growth factor A isoform X1 [KO:K05448]
111844528  vascular endothelial growth factor A-A-like isoform X1 [KO:K05448]
111852514  pgf; placenta growth factor [KO:K16859]
111845763  vegfc; vascular endothelial growth factor C isoform X1 [KO:K05449]
111838191  vegfd; vascular endothelial growth factor D isoform X1 [KO:K05449]
111850116  vascular endothelial growth factor C-like isoform X1 [KO:K05449]
111855173  vascular endothelial growth factor C-like isoform X1 [KO:K05449]
111846155  hgf; hepatocyte growth factor [KO:K05460]
111833314  hepatocyte growth factor-like isoform X1 [KO:K05460]
111850064  platelet-derived growth factor receptor alpha-like [KO:K04363] [EC:2.7.10.1]
111855164  pdgfrb; platelet-derived growth factor receptor beta isoform X1 [KO:K05089] [EC:2.7.10.1]
111845000  igf1r; insulin-like growth factor 1 receptor [KO:K05087] [EC:2.7.10.1]
111845734  insulin-like growth factor 1 receptor isoform X1 [KO:K05087] [EC:2.7.10.1]
111850117  kdr; vascular endothelial growth factor receptor 2 isoform X1 [KO:K05098] [EC:2.7.10.1]
111845900  epidermal growth factor receptor-like isoform X1 [KO:K04361] [EC:2.7.10.1]
111841598  epidermal growth factor receptor-like [KO:K04361] [EC:2.7.10.1]
111835053  vascular endothelial growth factor receptor kdr-like [KO:K05096] [EC:2.7.10.1]
111837761  vascular endothelial growth factor receptor 1-like isoform X1 [KO:K05096] [EC:2.7.10.1]
111838006  vascular endothelial growth factor receptor kdr-like [KO:K05096] [EC:2.7.10.1]
111857710  flt4; vascular endothelial growth factor receptor 3 isoform X1 [KO:K05097] [EC:2.7.10.1]
111842454  met; hepatocyte growth factor receptor [KO:K05099] [EC:2.7.10.1]
111836018  hepatocyte growth factor receptor-like isoform X1 [KO:K05099] [EC:2.7.10.1]
111854099  erbb2; receptor tyrosine-protein kinase erbB-2 [KO:K05083] [EC:2.7.10.1]
111837750  receptor tyrosine-protein kinase erbB-2-like [KO:K05083] [EC:2.7.10.1]
111853253  epithelial membrane protein 2-like [KO:K26255]
111841747  epithelial membrane protein 2-like [KO:K26255]
111835923  proto-oncogene tyrosine-protein kinase Src-like [KO:K05704] [EC:2.7.10.2]
111855741  proto-oncogene tyrosine-protein kinase Src isoform X1 [KO:K05704] [EC:2.7.10.2]
111844867  arhgap35; rho GTPase-activating protein 35 isoform X1 [KO:K05732]
111855024  arhgap5; rho GTPase-activating protein 5 [KO:K13709]
111842305  rho-related GTP-binding protein RhoA-C-like [KO:K04513]
111839832  rho-related GTP-binding protein RhoA-D [KO:K04513]
111851074  rho-related GTP-binding protein RhoA-D-like [KO:K04513]
111855859  rhoa; transforming protein RhoA [KO:K04513]
111857025  rho-related GTP-binding protein RhoA-C-like isoform X1 [KO:K04513]
111860004  transforming protein RhoA-like [KO:K04513]
111859846  diaph1; protein diaphanous homolog 1 isoform X1 [KO:K05740]
111845883  rock1; rho-associated protein kinase 1 [KO:K04514] [EC:2.7.11.1]
111851538  rho-associated protein kinase 2-like isoform X1 [KO:K17388] [EC:2.7.11.1]
111855542  rock2; rho-associated protein kinase 2 isoform X1 [KO:K17388] [EC:2.7.11.1]
111842153  myl2; myosin regulatory light chain 2, ventricular/cardiac muscle isoform [KO:K10351]
111842232  myl5; myosin light chain 5 [KO:K12753]
111857527  myl7; myosin regulatory light chain 2, atrial isoform isoform X1 [KO:K12754]
111856417  myosin regulatory light polypeptide 9 [KO:K12755]
111847855  myosin regulatory light chain 2B, cardiac muscle isoform-like [KO:K12756]
111841512  myosin regulatory light chain 2B, cardiac muscle isoform-like [KO:K12756]
111852553  myosin regulatory light chain 2, smooth muscle minor isoform [KO:K12757]
111857749  myosin regulatory light chain 2, smooth muscle minor isoform-like [KO:K12757]
111833122  myosin regulatory light chain 2, skeletal muscle isoform [KO:K12758]
111858833  myosin regulatory light chain 2, skeletal muscle isoform-like [KO:K12758]
111854055  myosin regulatory light chain 2, skeletal muscle isoform type 2-like isoform X1 [KO:K12758]
111840498  serine/threonine-protein phosphatase alpha-2 isoform-like [KO:K06269] [EC:3.1.3.16]
111842088  ppp1cc; serine/threonine-protein phosphatase PP1-gamma catalytic subunit [KO:K06269] [EC:3.1.3.16]
111849258  serine/threonine-protein phosphatase alpha-2 isoform-like [KO:K06269] [EC:3.1.3.16]
111842149  serine/threonine-protein phosphatase PP1-beta catalytic subunit-like [KO:K06269] [EC:3.1.3.16]
111850693  serine/threonine-protein phosphatase PP1-beta catalytic subunit-like [KO:K06269] [EC:3.1.3.16]
111855133  serine/threonine-protein phosphatase PP1-gamma catalytic subunit-like isoform X1 [KO:K06269] [EC:3.1.3.16]
111855420  serine/threonine-protein phosphatase PP1-beta catalytic subunit [KO:K06269] [EC:3.1.3.16]
111843391  ppp1r12a; protein phosphatase 1 regulatory subunit 12A isoform X1 [KO:K06270]
111855304  protein phosphatase 1 regulatory subunit 12B-like isoform X1 [KO:K12329]
111850734  protein phosphatase 1 regulatory subunit 12C-like [KO:K17457]
111839803  mylk2; myosin light chain kinase 2, skeletal/cardiac muscle [KO:K00907] [EC:2.7.11.18]
111858342  myosin light chain kinase, smooth muscle-like isoform X1 [KO:K00907] [EC:2.7.11.18]
111847736  mylk3; myosin light chain kinase 3 isoform X1 [KO:K00907] [EC:2.7.11.18]
111850056  myosin light chain kinase 2, skeletal/cardiac muscle-like isoform X1 [KO:K00907] [EC:2.7.11.18]
111856005  myosin light chain kinase, smooth muscle-like isoform X1 [KO:K00907] [EC:2.7.11.18]
111854340  myosin light chain kinase 2, skeletal/cardiac muscle-like [KO:K00907] [EC:2.7.11.18]
111842518  myosin light chain kinase, smooth muscle-like isoform X1 [KO:K00907] [EC:2.7.11.18]
111838414  phosphatidylinositol 4-phosphate 5-kinase type-1 alpha-like isoform X1 [KO:K00889] [EC:2.7.1.68]
111839723  phosphatidylinositol 4-phosphate 5-kinase type-1 alpha-like isoform X1 [KO:K00889] [EC:2.7.1.68]
111839411  pip5k1b; phosphatidylinositol 4-phosphate 5-kinase type-1 beta isoform X1 [KO:K00889] [EC:2.7.1.68]
111836580  phosphatidylinositol 4-phosphate 5-kinase type-1 gamma-like isoform X1 [KO:K00889] [EC:2.7.1.68]
111860294  phosphatidylinositol 4-phosphate 5-kinase type-1 gamma-like isoform X1 [KO:K00889] [EC:2.7.1.68]
111854072  actin, cytoplasmic 1 [KO:K05692]
111845463  actin, cytoplasmic 1 [KO:K05692]
111859362  ras-specific guanine nucleotide-releasing factor 1-like [KO:K04349]
111843577  ras-specific guanine nucleotide-releasing factor 1 isoform X1 [KO:K04349]
111852308  calpain-2 catalytic subunit-like [KO:K03853] [EC:3.4.22.53]
111835677  calpain-2 catalytic subunit-like [KO:K03853] [EC:3.4.22.53]
111852340  calpain-2 catalytic subunit-like [KO:K03853] [EC:3.4.22.53]
111852381  calpain-2 catalytic subunit-like [KO:K03853] [EC:3.4.22.53]
111852382  calpain-2 catalytic subunit-like [KO:K03853] [EC:3.4.22.53]
111841738  calpain-2 catalytic subunit-like isoform X1 [KO:K03853] [EC:3.4.22.53]
111844015  actn4; alpha-actinin-4 isoform X1 [KO:K05699]
111856226  alpha-actinin-1 isoform X1 [KO:K05699]
111859957  alpha-actinin-1-like isoform X1 [KO:K05699]
111846914  tln2; talin-2 [KO:K06271]
111834482  talin-1-like [KO:K06271]
111842285  filamin-A-like isoform X1 [KO:K04437]
111856989  filamin-A-like [KO:K04437]
111837459  flnb; filamin-B isoform X1 [KO:K27392]
111854687  paxillin [KO:K05760]
111858721  proline-rich protein 36-like isoform X1 [KO:K05760]
111860198  paxillin-like [KO:K05760]
111838003  integrin-linked protein kinase-like [KO:K06272] [EC:2.7.11.1]
111856818  ilk; integrin-linked protein kinase [KO:K06272] [EC:2.7.11.1]
111833956  zyx; zyxin isoform X1 [KO:K06273]
111860927  vasodilator-stimulated phosphoprotein-like [KO:K06274]
111850600  vasp; vasodilator-stimulated phosphoprotein isoform X1 [KO:K06274]
111850375  vinculin-like isoform X1 [KO:K05700]
111836731  vinculin isoform X1 [KO:K05700]
111832975  parva; alpha-parvin [KO:K06275]
111834161  beta-parvin-like isoform X1 [KO:K06275]
111833273  parvb; beta-parvin isoform X1 [KO:K06275]
111833274  parvg; gamma-parvin [KO:K06275]
111833435  3-phosphoinositide-dependent protein kinase 1-like isoform X1 [KO:K06276] [EC:2.7.11.1]
111846388  3-phosphoinositide-dependent protein kinase 1-like [KO:K06276] [EC:2.7.11.1]
111838854  RAC-alpha serine/threonine-protein kinase-like [KO:K04456] [EC:2.7.11.1]
111852355  akt3; RAC-gamma serine/threonine-protein kinase [KO:K04456] [EC:2.7.11.1]
111850633  RAC-beta serine/threonine-protein kinase isoform X1 [KO:K04456] [EC:2.7.11.1]
111860965  akt2; RAC-beta serine/threonine-protein kinase isoform X1 [KO:K04456] [EC:2.7.11.1]
111861008  RAC-alpha serine/threonine-protein kinase [KO:K04456] [EC:2.7.11.1]
111836509  glycogen synthase kinase-3 beta-like isoform X1 [KO:K03083] [EC:2.7.11.26]
111852698  glycogen synthase kinase-3 beta isoform X1 [KO:K03083] [EC:2.7.11.26]
111840912  catenin beta-1-like isoform X1 [KO:K02105]
111852439  ctnnb1; catenin beta-1 [KO:K02105]
111843225  protein kinase C alpha type-like isoform X1 [KO:K02677] [EC:2.7.11.13]
111848649  prkca; protein kinase C alpha type isoform X1 [KO:K02677] [EC:2.7.11.13]
111845521  protein kinase C beta type isoform X1 [KO:K19662] [EC:2.7.11.13]
111849289  protein kinase C beta type isoform X1 [KO:K19662] [EC:2.7.11.13]
111853291  protein kinase C alpha type-like [KO:K19663] [EC:2.7.11.13]
111843830  ptk2; focal adhesion kinase 1 isoform X1 [KO:K05725] [EC:2.7.10.2]
111844688  focal adhesion kinase 1-like isoform X1 [KO:K05725] [EC:2.7.10.2]
111836364  phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform-like isoform X1 [KO:K00922] [EC:2.7.1.153]
111860453  pik3ca; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform [KO:K00922] [EC:2.7.1.153]
111853566  phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform [KO:K00922] [EC:2.7.1.153]
111860909  pik3cb; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform [KO:K00922] [EC:2.7.1.153]
111853393  pik3cd; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform [KO:K00922] [EC:2.7.1.153]
111835615  pik3r1; phosphatidylinositol 3-kinase regulatory subunit alpha isoform X1 [KO:K02649]
111834821  pik3r3; phosphatidylinositol 3-kinase regulatory subunit gamma isoform X1 [KO:K02649]
111847640  phosphatidylinositol 3-kinase regulatory subunit gamma-like isoform X1 [KO:K02649]
111860386  pik3r2; phosphatidylinositol 3-kinase regulatory subunit beta [KO:K02649]
111856594  phosphatidylinositol 3-kinase regulatory subunit alpha-like [KO:K02649]
111853698  pten; phosphatidylinositol 3,4,5-trisphosphate 3-phosphatase and dual-specificity protein phosphatase PTEN isoform X1 [KO:K01110] [EC:3.1.3.16 3.1.3.48 3.1.3.67]
111858884  phosphatidylinositol 3,4,5-trisphosphate 3-phosphatase and dual-specificity protein phosphatase PTEN-like isoform X1 [KO:K01110] [EC:3.1.3.16 3.1.3.48 3.1.3.67]
111847476  guanine nucleotide exchange factor VAV2-like isoform X1 [KO:K05730]
111840798  guanine nucleotide exchange factor VAV3-like [KO:K05730]
111842692  guanine nucleotide exchange factor VAV2-like isoform X1 [KO:K05730]
111835106  vav1; proto-oncogene vav isoform X1 [KO:K05730]
111849363  proto-oncogene vav-like isoform X1 [KO:K05730]
111849433  guanine nucleotide exchange factor VAV3-like [KO:K05730]
111856067  rac1; ras-related C3 botulinum toxin substrate 1 [KO:K04392]
111853849  ras-related C3 botulinum toxin substrate 1-like isoform X1 [KO:K04392]
111853850  ras-related C3 botulinum toxin substrate 1-like [KO:K04392]
111843315  ras-related C3 botulinum toxin substrate 2 [KO:K07860]
111859727  ras-related C3 botulinum toxin substrate 2-like [KO:K07860]
111848451  rac3; ras-related C3 botulinum toxin substrate 3 [KO:K07861]
111856750  ras-related C3 botulinum toxin substrate 3-like [KO:K07861]
111833901  pak1; serine/threonine-protein kinase PAK 1 [KO:K04409] [EC:2.7.11.1]
111842626  serine/threonine-protein kinase PAK 1-like [KO:K04409] [EC:2.7.11.1]
111832832  pak2; serine/threonine-protein kinase PAK 2 [KO:K04410] [EC:2.7.11.1]
111847400  serine/threonine-protein kinase PAK 2-like [KO:K04410] [EC:2.7.11.1]
111859832  serine/threonine-protein kinase PAK 3-like isoform X1 [KO:K05733] [EC:2.7.11.1]
111860865  serine/threonine-protein kinase PAK 3 isoform X1 [KO:K05733] [EC:2.7.11.1]
111844083  pak4; serine/threonine-protein kinase PAK 4 isoform X1 [KO:K05734] [EC:2.7.11.1]
111837469  pak5; serine/threonine-protein kinase PAK 5 isoform X1 [KO:K05736] [EC:2.7.11.1]
111838882  pak6; serine/threonine-protein kinase PAK 6 isoform X1 [KO:K05735] [EC:2.7.11.1]
111834408  cell division control protein 42 homolog isoform X1 [KO:K04393]
111834477  cell division control protein 42 homolog isoform X1 [KO:K04393]
111835374  cell division control protein 42 homolog isoform X1 [KO:K04393]
111851927  bcar1; breast cancer anti-estrogen resistance protein 1 isoform X1 [KO:K05726]
111859378  breast cancer anti-estrogen resistance protein 1-like isoform X1 [KO:K05726]
111840455  adapter molecule crk-like [KO:K04438]
111833226  crk-like protein [KO:K04438]
111851785  crk-like protein [KO:K04438]
111833879  adapter molecule crk-like isoform X1 [KO:K04438]
111853665  dock1; dedicator of cytokinesis protein 1 isoform X1 [KO:K13708]
111841868  rapgef1; rap guanine nucleotide exchange factor 1 isoform X1 [KO:K06277]
111839862  ras-related protein Rap-1A-like isoform X1 [KO:K04353]
111851087  rap1a; ras-related protein Rap-1A [KO:K04353]
111844324  ras-related protein Rap-1b-like [KO:K07836]
111851234  rap1b; ras-related protein Rap-1b [KO:K07836]
111850762  mitogen-activated protein kinase 9-like [KO:K04440] [EC:2.7.11.24]
111839372  mitogen-activated protein kinase 10-like isoform X1 [KO:K04440] [EC:2.7.11.24]
111850356  mapk8; mitogen-activated protein kinase 8 isoform X1 [KO:K04440] [EC:2.7.11.24]
111848368  mitogen-activated protein kinase 8 isoform X1 [KO:K04440] [EC:2.7.11.24]
111852585  mapk10; mitogen-activated protein kinase 10 isoform X1 [KO:K04440] [EC:2.7.11.24]
111855469  mitogen-activated protein kinase 9-like isoform X1 [KO:K04440] [EC:2.7.11.24]
111842196  transcription factor AP-1-like [KO:K04448]
111834818  transcription factor AP-1-like [KO:K04448]
111847550  transcription factor AP-1-like [KO:K04448]
111836730  braf; serine/threonine-protein kinase B-raf isoform X1 [KO:K04365] [EC:2.7.11.1]
111842435  caveolin-1-like [KO:K06278]
111836013  caveolin-1-like [KO:K06278]
111842436  caveolin-2-like [KO:K12958]
111836012  caveolin-2-like [KO:K12958]
111837470  caveolin-2-like [KO:K12958]
111835920  caveolin-3-like [KO:K12959]
111840522  caveolin-3-like [KO:K12959]
111843036  fyn; tyrosine-protein kinase Fyn [KO:K05703] [EC:2.7.10.2]
111857866  tyrosine-protein kinase fyna [KO:K05703] [EC:2.7.10.2]
111848307  shc1; LOW QUALITY PROTEIN: SHC-transforming protein 1 [KO:K06279]
111860152  shc2; SHC-transforming protein 2 isoform X1 [KO:K17447]
111833617  shc3; SHC-transforming protein 3 isoform X1 [KO:K17448]
111844965  shc4; SHC-transforming protein 4 isoform X1 [KO:K17449]
111833563  growth factor receptor-bound protein 2-like isoform X1 [KO:K04364]
111834215  grb2; growth factor receptor-bound protein 2 [KO:K04364]
111835740  LOW QUALITY PROTEIN: son of sevenless homolog 1-like [KO:K03099]
111836934  son of sevenless homolog 1-like [KO:K03099]
111840699  GTPase HRas-like [KO:K02833]
111859528  hras; GTPase HRas [KO:K02833]
111837477  raf1; RAF proto-oncogene serine/threonine-protein kinase isoform X1 [KO:K04366] [EC:2.7.11.1]
111840300  RAF proto-oncogene serine/threonine-protein kinase-like isoform X1 [KO:K04366] [EC:2.7.11.1]
111845607  map2k1; dual specificity mitogen-activated protein kinase kinase 1 [KO:K04368] [EC:2.7.12.2]
111835825  mitogen-activated protein kinase 1-like [KO:K04371] [EC:2.7.11.24]
111857802  mapk1; mitogen-activated protein kinase 1 [KO:K04371] [EC:2.7.11.24]
111856137  ETS domain-containing protein Elk-1-like isoform X1 [KO:K04375]
111851863  G1/S-specific cyclin-D1 [KO:K04503]
111836806  G1/S-specific cyclin-D2-like [KO:K10151]
111851230  G1/S-specific cyclin-D2-like isoform X1 [KO:K10151]
111858241  G1/S-specific cyclin-D2-like [KO:K10151]
111857566  ccnd2; G1/S-specific cyclin-D2 isoform X1 [KO:K10151]
111852988  ccnd3; G1/S-specific cyclin-D3 isoform X1 [KO:K10152]
111838067  baculoviral IAP repeat-containing protein 2-like [KO:K16060]
111853545  xiap; E3 ubiquitin-protein ligase XIAP isoform X1 [KO:K04725] [EC:2.3.2.27]
111834777  bad; bcl2-associated agonist of cell death isoform X1 [KO:K02158]
111851660  apoptosis regulator Bcl-2-like [KO:K02161]
111845833  apoptosis regulator Bcl-2-like [KO:K02161]
Compound
C04637  1-Phosphatidyl-D-myo-inositol 4,5-bisphosphate
C05981  Phosphatidylinositol-3,4,5-trisphosphate
Reference
PMID:14756624
  Authors
Berman AE, Kozlova NI, Morozevich GE.
  Title
Integrins: structure and signaling.
  Journal
Biochemistry (Mosc) 68:1284-99 (2003)
DOI:10.1023/b:biry.0000011649.03634.74
Reference
PMID:15179030
  Authors
Lee JW, Juliano R.
  Title
Mitogenic signal transduction by integrin- and growth factor receptor-mediated pathways.
  Journal
Mol Cells 17:188-202 (2004)
Reference
PMID:11573199
  Authors
Danen EH, Yamada KM.
  Title
Fibronectin, integrins, and growth control.
  Journal
J Cell Physiol 189:1-13 (2001)
DOI:10.1002/jcp.1137
Reference
PMID:15459662
  Authors
Guo W, Giancotti FG.
  Title
Integrin signalling during tumour progression.
  Journal
Nat Rev Mol Cell Biol 5:816-26 (2004)
DOI:10.1038/nrm1490
Reference
PMID:11229600
  Authors
Petit V, Thiery JP.
  Title
Focal adhesions: structure and dynamics.
  Journal
Biol Cell 92:477-94 (2000)
DOI:10.1016/S0248-4900(00)01101-1
Reference
PMID:12235283
  Authors
Stupack DG, Cheresh DA.
  Title
Get a ligand, get a life: integrins, signaling and cell survival.
  Journal
J Cell Sci 115:3729-38 (2002)
DOI:10.1242/jcs.00071
Reference
PMID:12640026
  Authors
Parsons JT.
  Title
Focal adhesion kinase: the first ten years.
  Journal
J Cell Sci 116:1409-16 (2003)
DOI:10.1242/jcs.00373
Reference
PMID:15688067
  Authors
Mitra SK, Hanson DA, Schlaepfer DD.
  Title
Focal adhesion kinase: in command and control of cell motility.
  Journal
Nat Rev Mol Cell Biol 6:56-68 (2005)
DOI:10.1038/nrm1549
Reference
PMID:14519391
  Authors
Comoglio PM, Boccaccio C, Trusolino L.
  Title
Interactions between growth factor receptors and adhesion molecules: breaking the rules.
  Journal
Curr Opin Cell Biol 15:565-71 (2003)
DOI:10.1016/S0955-0674(03)00096-6
Reference
PMID:15108811
  Authors
Schlaepfer DD, Mitra SK.
  Title
Multiple connections link FAK to cell motility and invasion.
  Journal
Curr Opin Genet Dev 14:92-101 (2004)
DOI:10.1016/j.gde.2003.12.002
Reference
PMID:14744429
  Authors
Burridge K, Wennerberg K.
  Title
Rho and Rac take center stage.
  Journal
Cell 116:167-79 (2004)
DOI:10.1016/S0092-8674(04)00003-0
Reference
PMID:11082269
  Authors
Schmitz AA, Govek EE, Bottner B, Van Aelst L.
  Title
Rho GTPases: signaling, migration, and invasion.
  Journal
Exp Cell Res 261:1-12 (2000)
DOI:10.1006/excr.2000.5049
Reference
PMID:10698680
  Authors
Vanhaesebroeck B, Alessi DR.
  Title
The PI3K-PDK1 connection: more than just a road to PKB.
  Journal
Biochem J 346 Pt 3:561-76 (2000)
DOI:10.1042/bj3460561
Reference
PMID:11882383
  Authors
Nicholson KM, Anderson NG.
  Title
The protein kinase B/Akt signalling pathway in human malignancy.
  Journal
Cell Signal 14:381-95 (2002)
DOI:10.1016/S0898-6568(01)00271-6
Reference
PMID:15053919
  Authors
Oloumi A, McPhee T, Dedhar S.
  Title
Regulation of E-cadherin expression and beta-catenin/Tcf transcriptional activity by the integrin-linked kinase.
  Journal
Biochim Biophys Acta 1691:1-15 (2004)
DOI:10.1016/j.bbamcr.2003.12.002
Reference
PMID:11146675
  Authors
Turner CE.
  Title
Paxillin and focal adhesion signalling.
  Journal
Nat Cell Biol 2:E231-6 (2000)
DOI:10.1038/35046659
Reference
PMID:15034601
  Authors
Hlobilkova A, Knillova J, Bartek J, Lukas J, Kolar Z.
  Title
The mechanism of action of the tumour suppressor gene PTEN.
  Journal
Biomed Pap Med Fac Univ Palacky Olomouc Czech Repub 147:19-25 (2003)
Related
pathway
pki04010  MAPK signaling pathway
pki04060  Cytokine-cytokine receptor interaction
pki04070  Phosphatidylinositol signaling system
pki04110  Cell cycle
pki04310  Wnt signaling pathway
pki04512  ECM-receptor interaction
pki04810  Regulation of actin cytoskeleton
KO pathway
ko04510   
LinkDB

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