Entry
Name
Herpes simplex virus 1 infection - Rhinopithecus roxellana (golden snub-nosed monkey)
Description
Herpes simplex virus 1(HSV-1) is a common human pathogen, which initially infects orofacial mucosal surfaces. The virus replicates in epithelial cells at these sites, causing clinically overt disease characterized by vesicular lesions. HSV-1 then penetrates to the nervous system and establishes latency in sensory neurons. Throughout the lifetime of the host, HSV-1 may reactivate from its latent state and reinitiate a lytic infection cycle. HSV-1 has developed various mechanisms to escape its host innate immune responses and increased its capacity to replicate and to persist. ICP34.5, ICP0, ICP27, Us11 and Vhs (UL41) are the proteins involved in viral interference.
Class
Human Diseases; Infectious disease: viral
BRITE hierarchy
Pathway map
rro05168 Herpes simplex virus 1 infection
Ortholog table
Organism
Rhinopithecus roxellana (golden snub-nosed monkey) [GN:
rro ]
Gene
104665362 TNFSF14; tumor necrosis factor ligand superfamily member 14 isoform X1 [KO:K05477 ]
104664579 TNFRSF14; tumor necrosis factor receptor superfamily member 14 isoform X1 [KO:K05152 ]
104662315 NFKB1; nuclear factor NF-kappa-B p105 subunit isoform X1 [KO:K02580 ]
104674658 BIRC2; baculoviral IAP repeat-containing protein 2 isoform X2 [KO:K16060 ]
104673605 PILRB; paired immunoglobulin-like type 2 receptor beta isoform X8 [KO:K15411 ]
104673606 PILRA; paired immunoglobulin-like type 2 receptor alpha isoform X1 [KO:K15411 ]
104669676 CARD9; caspase recruitment domain-containing protein 9 [KO:K12794 ]
104657448 MYD88; myeloid differentiation primary response protein MyD88 isoform X1 [KO:K04729 ]
104682560 TAB1; TGF-beta-activated kinase 1 and MAP3K7-binding protein 1 isoform X1 [KO:K04403 ]
104676257 TAB2; TGF-beta-activated kinase 1 and MAP3K7-binding protein 2 [KO:K04404 ]
115899261 LOW QUALITY PROTEIN: TGF-beta-activated kinase 1 and MAP3K7-binding protein 2-like [KO:K04404 ]
104681744 STING1; stimulator of interferon genes protein isoform X1 [KO:K12654 ]
104669977 EIF2AK2; interferon-induced, double-stranded RNA-activated protein kinase isoform X1 [KO:K16195 ] [EC:2.7.11.1 ]
104665027 EIF2S1; eukaryotic translation initiation factor 2 subunit 1 [KO:K03237 ]
104666328 EIF2B1; translation initiation factor eIF-2B subunit alpha [KO:K03239 ]
104677583 EIF2B2; translation initiation factor eIF-2B subunit beta [KO:K03754 ]
104678256 EIF2B3; translation initiation factor eIF-2B subunit gamma [KO:K03241 ]
104668490 EIF2B4; translation initiation factor eIF-2B subunit delta isoform X2 [KO:K03680 ]
104664636 EIF2B5; translation initiation factor eIF-2B subunit epsilon [KO:K03240 ]
104658824 POU2F2; POU domain, class 2, transcription factor 2 isoform X9 [KO:K09364 ]
104668980 POU2F1; POU domain, class 2, transcription factor 1 isoform X2 [KO:K09364 ]
104657225 POU2F3; POU domain, class 2, transcription factor 3 isoform X1 [KO:K09364 ]
104675282 STAT1; signal transducer and activator of transcription 1-alpha/beta [KO:K11220 ]
104673676 STAT2; signal transducer and activator of transcription 2 [KO:K11221 ]
104666129 RBAK; RB-associated KRAB zinc finger protein isoform X1 [KO:K09228 ]
104681611 ZNF747; KRAB domain-containing protein ZNF747 isoform X2 [KO:K09228 ]
104680904 ZIK1; zinc finger protein interacting with ribonucleoprotein K isoform X1 [KO:K09228 ]
104672300 ZSCAN32; zinc finger and SCAN domain-containing protein 32 [KO:K09228 ]
104661149 ZNF788P; putative KRAB domain-containing protein ZNF788 [KO:K09228 ]
104670209 patr class I histocompatibility antigen, B-2 alpha chain isoform X1 [KO:K06751 ]
104668193 LOW QUALITY PROTEIN: HLA class I histocompatibility antigen, B-42 alpha chain-like [KO:K06751 ]
104674706 LOW QUALITY PROTEIN: class I histocompatibility antigen, Gogo-B*0101 alpha chain-like [KO:K06751 ]
104661905 saoe class I histocompatibility antigen, A alpha chain-like [KO:K06751 ]
115897009 HLA class I histocompatibility antigen, B-15 alpha chain-like [KO:K06751 ]
104676771 mamu class I histocompatibility antigen, alpha chain F [KO:K06751 ]
104678084 HLA class I histocompatibility antigen, B-38 alpha chain-like [KO:K06751 ]
104668434 HLA class I histocompatibility antigen, A-30 alpha chain isoform X1 [KO:K06751 ]
104677089 class I histocompatibility antigen, Gogo-B*0102 alpha chain-like isoform X1 [KO:K06751 ]
104673193 LOW QUALITY PROTEIN: HLA class I histocompatibility antigen, B-14 alpha chain [KO:K06751 ]
104676774 class I histocompatibility antigen, Gogo-B*0101 alpha chain-like [KO:K06751 ]
104666183 popy class I histocompatibility antigen, alpha chain E isoform X1 [KO:K06751 ]
104678248 LOW QUALITY PROTEIN: HLA class I histocompatibility antigen, B-67 alpha chain [KO:K06751 ]
104657986 HLA class II histocompatibility antigen, DP beta 1 chain [KO:K06752 ]
104657985 HLA class II histocompatibility antigen, DP alpha 1 chain [KO:K06752 ]
104673877 HLA class II histocompatibility antigen, DRB1-1 beta chain [KO:K06752 ]
104673884 mamu class II histocompatibility antigen, DR alpha chain [KO:K06752 ]
104673840 HLA class II histocompatibility antigen, DO beta chain [KO:K06752 ]
104673850 HLA class II histocompatibility antigen, DQ beta 1 chain isoform X1 [KO:K06752 ]
104673860 HLA class II histocompatibility antigen, DQ alpha 1 chain [KO:K06752 ]
104673868 HLA class II histocompatibility antigen, DRB1-10 beta chain [KO:K06752 ]
104666619 HLA class II histocompatibility antigen, DO alpha chain isoform X1 [KO:K06752 ]
104666621 HLA class II histocompatibility antigen, DM alpha chain isoform X1 [KO:K06752 ]
104666623 HLA class II histocompatibility antigen, DM beta chain isoform X1 [KO:K06752 ]
104670416 CD74; HLA class II histocompatibility antigen gamma chain isoform X1 [KO:K06505 ]
104663050 PIK3CD; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform isoform X1 [KO:K00922 ] [EC:2.7.1.153 ]
104665061 PIK3CB; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform isoform X1 [KO:K00922 ] [EC:2.7.1.153 ]
104670605 PIK3CA; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform [KO:K00922 ] [EC:2.7.1.153 ]
104662124 PIK3R3; phosphatidylinositol 3-kinase regulatory subunit gamma [KO:K02649 ]
104675620 PIK3R1; phosphatidylinositol 3-kinase regulatory subunit alpha isoform X1 [KO:K02649 ]
104680672 PIK3R2; phosphatidylinositol 3-kinase regulatory subunit beta [KO:K02649 ]
104679650 EIF4EBP1; eukaryotic translation initiation factor 4E-binding protein 1 [KO:K07205 ]
104659643 SRSF5; serine/arginine-rich splicing factor 5 isoform X1 [KO:K12893 ]
104678890 LOW QUALITY PROTEIN: serine/arginine-rich splicing factor 6 [KO:K12893 ]
104663017 SRSF7; serine/arginine-rich splicing factor 7 isoform X1 [KO:K12896 ]
115898698 LOW QUALITY PROTEIN: nuclear RNA export factor 2-like [KO:K14284 ]
104669600 FASLG; tumor necrosis factor ligand superfamily member 6 [KO:K04389 ]
104675147 FAS; tumor necrosis factor receptor superfamily member 6 isoform X1 [KO:K04390 ]
104680127 TNFRSF1A; tumor necrosis factor receptor superfamily member 1A [KO:K03158 ]
104655653 TRADD; tumor necrosis factor receptor type 1-associated DEATH domain protein isoform X2 [KO:K03171 ]
104656342 APAF1; apoptotic protease-activating factor 1 isoform X1 [KO:K02084 ]
Compound
C05981 Phosphatidylinositol-3,4,5-trisphosphate
Reference
Authors
Granger SW, Rickert S
Title
LIGHT-HVEM signaling and the regulation of T cell-mediated immunity.
Journal
Reference
Authors
Steinberg MW, Shui JW, Ware CF, Kronenberg M
Title
Regulating the mucosal immune system: the contrasting roles of LIGHT, HVEM, and their various partners.
Journal
Reference
Authors
MacLeod IJ, Minson T
Title
Binding of herpes simplex virus type-1 virions leads to the induction of intracellular signalling in the absence of virus entry.
Journal
Reference
Authors
Gianni T, Leoni V, Chesnokova LS, Hutt-Fletcher LM, Campadelli-Fiume G
Title
alphavbeta3-integrin is a major sensor and activator of innate immunity to herpes simplex virus-1.
Journal
Reference
Authors
Gianni T, Campadelli-Fiume G
Title
The epithelial alphavbeta3-integrin boosts the MYD88-dependent TLR2 signaling in response to viral and bacterial components.
Journal
Reference
Authors
Spear PG
Title
Herpes simplex virus: receptors and ligands for cell entry.
Journal
Reference
Authors
Boutell C, Everett RD
Title
The herpes simplex virus type 1 (HSV-1) regulatory protein ICP0 interacts with and Ubiquitinates p53.
Journal
Reference
Authors
Ma Y, He B
Title
Recognition of herpes simplex viruses: toll-like receptors and beyond.
Journal
Reference
Authors
Su C, Zhan G, Zheng C
Title
Evasion of host antiviral innate immunity by HSV-1, an update.
Journal
Reference
Authors
Melchjorsen J, Matikainen S, Paludan SR
Title
Activation and evasion of innate antiviral immunity by herpes simplex virus.
Journal
Reference
Authors
Morrison LA
Title
The Toll of herpes simplex virus infection.
Journal
Reference
Authors
Zheng C
Title
Evasion of Cytosolic DNA-Stimulated Innate Immune Responses by Herpes Simplex Virus 1.
Journal
Reference
Authors
Grandi P, Peruzzi P, Reinhart B, Cohen JB, Chiocca EA, Glorioso JC
Title
Design and application of oncolytic HSV vectors for glioblastoma therapy.
Journal
Reference
Authors
Lussignol M, Queval C, Bernet-Camard MF, Cotte-Laffitte J, Beau I, Codogno P, Esclatine A
Title
The herpes simplex virus 1 Us11 protein inhibits autophagy through its interaction with the protein kinase PKR.
Journal
Reference
Authors
Sanchez R, Mohr I
Title
Inhibition of cellular 2'-5' oligoadenylate synthetase by the herpes simplex virus type 1 Us11 protein.
Journal
Reference
Authors
Wysocka J, Herr W
Title
The herpes simplex virus VP16-induced complex: the makings of a regulatory switch.
Journal
Reference
Authors
Fleming SB
Title
Viral Inhibition of the IFN-Induced JAK/STAT Signalling Pathway: Development of Live Attenuated Vaccines by Mutation of Viral-Encoded IFN-Antagonists.
Journal
Reference
Authors
Yokota S, Yokosawa N, Okabayashi T, Suzutani T, Miura S, Jimbow K, Fujii N
Title
Induction of suppressor of cytokine signaling-3 by herpes simplex virus type 1 contributes to inhibition of the interferon signaling pathway.
Journal
Reference
Authors
Gu H, Zheng Y, Roizman B
Title
Interaction of herpes simplex virus ICP0 with ND10 bodies: a sequential process of adhesion, fusion, and retention.
Journal
Reference
Authors
Tavalai N, Stamminger T
Title
Interplay between Herpesvirus Infection and Host Defense by PML Nuclear Bodies.
Journal
Reference
Authors
Horst D, Verweij MC, Davison AJ, Ressing ME, Wiertz EJ
Title
Viral evasion of T cell immunity: ancient mechanisms offering new applications.
Journal
Reference
Authors
Neumann J, Eis-Hubinger AM, Koch N
Title
Herpes simplex virus type 1 targets the MHC class II processing pathway for immune evasion.
Journal
Reference
Authors
Liu X, Cohen JI
Title
The role of PI3K/Akt in human herpesvirus infection: From the bench to the bedside.
Journal
Reference
Authors
Vink EI, Smiley JR, Mohr I
Title
Subversion of Host Responses to Energy Insufficiency by Us3 Supports Herpes Simplex Virus 1 Replication during Stress.
Journal
Reference
Authors
Sandri-Goldin RM
Title
The many roles of the regulatory protein ICP27 during herpes simplex virus infection.
Journal
Reference
Authors
Sandri-Goldin RM
Title
Viral regulation of mRNA export.
Journal
Reference
Authors
Yu X, He S
Title
The interplay between human herpes simplex virus infection and the apoptosis and necroptosis cell death pathways.
Journal
Related pathway
rro04610 Complement and coagulation cascades
rro04612 Antigen processing and presentation
rro04620 Toll-like receptor signaling pathway
rro04622 RIG-I-like receptor signaling pathway
KO pathway
LinkDB
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