KEGG   PATHWAY: stru04110
Entry
stru04110                   Pathway                                
Name
Cell cycle - Salmo trutta (river trout)
Description
Mitotic cell cycle progression is accomplished through a reproducible sequence of events, DNA replication (S phase) and mitosis (M phase) separated temporally by gaps known as G1 and G2 phases. Cyclin-dependent kinases (CDKs) are key regulatory enzymes, each consisting of a catalytic CDK subunit and an activating cyclin subunit. CDKs regulate the cell's progression through the phases of the cell cycle by modulating the activity of key substrates. Downstream targets of CDKs include transcription factor E2F and its regulator Rb. Precise activation and inactivation of CDKs at specific points in the cell cycle are required for orderly cell division. Cyclin-CDK inhibitors (CKIs), such as p16Ink4a, p15Ink4b, p27Kip1, and p21Cip1, are involved in the negative regulation of CDK activities, thus providing a pathway through which the cell cycle is negatively regulated.
 Eukaryotic cells respond to DNA damage by activating signaling pathways that promote cell cycle arrest and DNA repair. In response to DNA damage, the checkpoint kinase ATM phosphorylates and activates Chk2, which in turn directly phosphorylates and activates p53 tumor suppressor protein. p53 and its transcriptional targets play an important role in both G1 and G2 checkpoints. ATR-Chk1-mediated protein degradation of Cdc25A protein phosphatase is also a mechanism conferring intra-S-phase checkpoint activation.
Class
Cellular Processes; Cell growth and death
Pathway map
stru04110  Cell cycle
stru04110

Other DBs
GO: 0000278
Organism
Salmo trutta (river trout) [GN:stru]
Gene
115152358  G1/S-specific cyclin-D1-like [KO:K04503]
115167492  G1/S-specific cyclin-D1 [KO:K04503]
115202965  G1/S-specific cyclin-D1-like [KO:K04503]
115197603  G1/S-specific cyclin-D1-like [KO:K04503]
115152238  G1/S-specific cyclin-D2 isoform X1 [KO:K10151]
115180633  G1/S-specific cyclin-D2-like [KO:K10151]
115170698  G1/S-specific cyclin-D2-like [KO:K10151]
115197442  G1/S-specific cyclin-D2-like isoform X1 [KO:K10151]
115204775  G1/S-specific cyclin-D2-like [KO:K10151]
115198916  G1/S-specific cyclin-D2-like [KO:K10151]
115150620  G1/S-specific cyclin-D2-like [KO:K10152]
115150473  cyclin-dependent kinase 4-like [KO:K02089] [EC:2.7.11.22]
115207950  cyclin-dependent kinase 4-like [KO:K02089] [EC:2.7.11.22]
115174024  cyclin-dependent kinase 6-like [KO:K02091] [EC:2.7.11.22]
115175534  cyclin-dependent kinase 6-like [KO:K02091] [EC:2.7.11.22]
115171057  cyclin-dependent kinase 6-like [KO:K02091] [EC:2.7.11.22]
115154441  rb1; retinoblastoma-associated protein [KO:K06618]
115208414  rbl1; retinoblastoma-like protein 1 isoform X1 [KO:K04681]
115152303  retinoblastoma-like protein 2 isoform X1 [KO:K16332]
115167022  retinoblastoma-like protein 2 isoform X1 [KO:K16332]
115203296  retinoblastoma-like protein 2 isoform X1 [KO:K16332]
115197515  retinoblastoma-like protein 2 [KO:K16332]
115159563  tyrosine-protein kinase ABL1-like isoform X1 [KO:K06619] [EC:2.7.10.2]
115204069  tyrosine-protein kinase ABL1-like isoform X1 [KO:K06619] [EC:2.7.10.2]
115174133  probable histone deacetylase 1-B [KO:K06067] [EC:3.5.1.98]
115176317  probable histone deacetylase 1-B [KO:K06067] [EC:3.5.1.98]
115162437  probable histone deacetylase 1-B [KO:K06067] [EC:3.5.1.98]
115172722  probable histone deacetylase 1-B [KO:K06067] [EC:3.5.1.98]
115194183  histone deacetylase 2 [KO:K06067] [EC:3.5.1.98]
115168160  transcription factor E2F1-like [KO:K17454]
115165830  transcription factor E2F1-like isoform X1 [KO:K17454]
115162585  transcription factor E2F2-like [KO:K09389]
115172886  transcription factor E2F2-like [KO:K09389]
115181710  transcription factor E2F3-like [KO:K06620]
115181720  transcription factor E2F3-like [KO:K06620]
115184937  transcription factor E2F3-like isoform X1 [KO:K06620]
115176324  transcription factor E2F3-like [KO:K06620]
115152244  e2f4; transcription factor E2F4 [KO:K04682]
115167192  transcription factor E2F4-like [KO:K04682]
115156777  transcription factor E2F5-like isoform X1 [KO:K04682]
115203140  transcription factor E2F4-like [KO:K04682]
115197458  transcription factor E2F4-like [KO:K04682]
115155887  transcription factor Dp-1-like isoform X1 [KO:K04683]
115179526  transcription factor Dp-1-like [KO:K04683]
115179527  transcription factor Dp-1-like [KO:K04683]
115161278  transcription factor Dp-1-like isoform X1 [KO:K04683]
115205830  transcription factor Dp-2-like isoform X1 [KO:K09392]
115155817  glycogen synthase kinase-3 beta-like isoform X1 [KO:K03083] [EC:2.7.11.26]
115161154  glycogen synthase kinase-3 beta isoform X1 [KO:K03083] [EC:2.7.11.26]
115179842  glycogen synthase kinase-3 beta-like isoform X1 [KO:K03083] [EC:2.7.11.26]
115195960  glycogen synthase kinase-3 beta-like isoform X1 [KO:K03083] [EC:2.7.11.26]
115154758  transforming growth factor beta-1 proprotein-like [KO:K13375]
115206692  transforming growth factor beta-1 proprotein-like [KO:K13375]
115204365  transforming growth factor beta-1 proprotein isoform X1 [KO:K13375]
115168917  transforming growth factor beta-2 proprotein-like [KO:K13376]
115175550  transforming growth factor beta-2 proprotein-like [KO:K13376]
115177416  transforming growth factor beta-2 proprotein-like [KO:K13376]
115205573  transforming growth factor beta-2 proprotein-like isoform X1 [KO:K13376]
115175155  transforming growth factor beta-3 proprotein-like [KO:K13377]
115162330  transforming growth factor beta-3 proprotein-like [KO:K13377]
115172613  transforming growth factor beta-3 proprotein-like [KO:K13377]
115151907  transforming growth factor beta-3 proprotein-like [KO:K13377]
115164783  mothers against decapentaplegic homolog 2 isoform X1 [KO:K04500]
115199870  mothers against decapentaplegic homolog 2-like isoform X1 [KO:K04500]
115192958  smad3; mothers against decapentaplegic homolog 3 [KO:K23605]
115166794  mothers against decapentaplegic homolog 3 [KO:K23605]
115164984  smad4; LOW QUALITY PROTEIN: mothers against decapentaplegic homolog 4 [KO:K04501]
115173628  mothers against decapentaplegic homolog 4-like isoform X1 [KO:K04501]
115175837  mothers against decapentaplegic homolog 4-like isoform X1 [KO:K04501]
115176558  mothers against decapentaplegic homolog 4-like isoform X1 [KO:K04501]
115159360  mothers against decapentaplegic homolog 4-like isoform X1 [KO:K04501]
115180008  mothers against decapentaplegic homolog 4-like isoform X1 [KO:K04501]
115149222  mothers against decapentaplegic homolog 4-like isoform X1 [KO:K04501]
115199711  mothers against decapentaplegic homolog 4-like [KO:K04501]
115154720  transcriptional regulator Myc-like [KO:K04377]
115156503  myc; myc proto-oncogene protein [KO:K04377]
115195764  transcriptional regulator Myc [KO:K04377]
115208402  transcriptional regulator Myc-2-like [KO:K04377]
115151122  transcriptional regulator Myc-2-like [KO:K04377]
115168205  zbtb17; zinc finger and BTB domain-containing protein 17 [KO:K10500]
115165870  zinc finger and BTB domain-containing protein 17-like [KO:K10500]
115191708  cyclin-dependent kinase 4 inhibitor B-like [KO:K04685]
115158388  cdkn2c; cyclin-dependent kinase 4 inhibitor C [KO:K06622]
115178553  cyclin-dependent kinase 4 inhibitor D-like [KO:K06623]
115147371  cyclin-dependent kinase 4 inhibitor D-like [KO:K06623]
115180610  cyclin-dependent kinase inhibitor 1B-like [KO:K06624]
115192669  cyclin-dependent kinase inhibitor 1B-like isoform X1 [KO:K06624]
115196967  cdkn1b; cyclin-dependent kinase inhibitor 1B [KO:K06624]
115198635  cyclin-dependent kinase inhibitor 1B-like [KO:K06624]
115152403  cyclin-dependent kinase inhibitor 1B-like [KO:K09993]
115152404  cyclin-dependent kinase inhibitor 1B-like [KO:K09993]
115167726  cyclin-dependent kinase inhibitor 1B-like [KO:K09993]
115203635  cyclin-dependent kinase inhibitor 1B-like isoform X1 [KO:K09993]
115197205  cyclin-dependent kinase inhibitor 1B-like [KO:K09993]
115180438  cyclin-dependent kinase inhibitor 1-like isoform X1 [KO:K06625]
115150615  cyclin-dependent kinase inhibitor 1-like [KO:K06625]
115207794  cyclin-dependent kinase inhibitor 1-like isoform X1 [KO:K06625]
115198721  cyclin-dependent kinase inhibitor 1-like isoform X1 [KO:K06625]
115176645  G1/S-specific cyclin-E2-like [KO:K06626]
115167446  ccne1; G1/S-specific cyclin-E1 [KO:K06626]
115179606  ccne2; G1/S-specific cyclin-E2 [KO:K06626]
115202935  G1/S-specific cyclin-E1-like [KO:K06626]
115150457  cdk2; cyclin-dependent kinase 2 [KO:K02206] [EC:2.7.11.22]
115207965  cyclin-dependent kinase 2-like [KO:K02206] [EC:2.7.11.22]
115154025  S-phase kinase-associated protein 1 [KO:K03094]
115148560  S-phase kinase-associated protein 1 [KO:K03094]
115152091  cullin-1-like [KO:K03347]
115169709  cullin-1 [KO:K03347]
115157067  cullin-1-like [KO:K03347]
115171287  RING-box protein 1 [KO:K03868] [EC:2.3.2.32]
115199956  RING-box protein 1 isoform X1 [KO:K03868] [EC:2.3.2.32]
115149232  skp2; S-phase kinase-associated protein 2 isoform X1 [KO:K03875]
115170290  cyclin-A2-like [KO:K06627]
115204637  ccna1; cyclin-A1 [KO:K06627]
115205091  cyclin-A2-like [KO:K06627]
115177789  cell division control protein 6 homolog [KO:K02213]
115208694  cell division control protein 6 homolog [KO:K02213]
115167385  DNA replication factor Cdt1-like [KO:K10727]
115202974  DNA replication factor Cdt1-like [KO:K10727]
115158748  orc1; origin recognition complex subunit 1 isoform X1 [KO:K02603]
115157676  orc2; origin recognition complex subunit 2 isoform X1 [KO:K02604]
115172845  orc3; origin recognition complex subunit 3 [KO:K02605]
115182099  origin recognition complex subunit 4-like [KO:K02606]
115180228  orc5; origin recognition complex subunit 5 [KO:K02607]
115202923  orc6; origin recognition complex subunit 6 [KO:K02608]
115150039  DNA replication licensing factor mcm2 [KO:K02540] [EC:5.6.2.3]
115207290  DNA replication licensing factor mcm2-like [KO:K02540] [EC:5.6.2.3]
115175145  DNA replication licensing factor MCM3-like [KO:K02541] [EC:5.6.2.3]
115158623  maternal DNA replication licensing factor mcm3-like isoform X1 [KO:K02541] [EC:5.6.2.3]
115169604  DNA replication licensing factor mcm4 [KO:K02212] [EC:5.6.2.3]
115157171  DNA replication licensing factor mcm4-like [KO:K02212] [EC:5.6.2.3]
115171366  DNA replication licensing factor mcm5-like [KO:K02209] [EC:5.6.2.3]
115201677  DNA replication licensing factor mcm5-like [KO:K02209] [EC:5.6.2.3]
115169469  zygotic DNA replication licensing factor mcm6-A-like [KO:K02542] [EC:5.6.2.3]
115157068  maternal DNA replication licensing factor mcm6-like [KO:K02542] [EC:5.6.2.3]
115157337  zygotic DNA replication licensing factor mcm6-B-like [KO:K02542] [EC:5.6.2.3]
115169507  mcm7; DNA replication licensing factor MCM7 [KO:K02210] [EC:5.6.2.3]
115200296  cdc45; cell division control protein 45 homolog [KO:K06628]
115192841  ticrr; treslin isoform X1 [KO:K26117]
115182480  mtbp; mdm2-binding protein [KO:K26116]
115169998  cdc7; cell division cycle 7-related protein kinase isoform X1 [KO:K02214] [EC:2.7.11.1]
115187232  protein DBF4 homolog A-like isoform X1 [KO:K06629]
115177471  protein DBF4 homolog A-like isoform X1 [KO:K06629]
115160607  uncharacterized protein LOC115160607 isoform X1 [KO:K06629]
115193676  cyclin-dependent kinase 1 [KO:K02087] [EC:2.7.11.22 2.7.11.23]
115153283  cyclin-dependent kinase 1-like [KO:K02087] [EC:2.7.11.22 2.7.11.23]
115159595  G2/mitotic-specific cyclin-B1-like [KO:K05868]
115203015  G2/mitotic-specific cyclin-B1-like isoform X1 [KO:K05868]
115204043  G2/mitotic-specific cyclin-B1-like [KO:K05868]
115163682  cntd2; cyclin N-terminal domain-containing protein 2 [KO:K21770]
115167247  G2/mitotic-specific cyclin-B2-like [KO:K21770]
115190418  G2/mitotic-specific cyclin-B3-like [KO:K21771]
115161818  cdc25b; M-phase inducer phosphatase 2 [KO:K05866] [EC:3.1.3.48]
115173049  M-phase inducer phosphatase 1-like [KO:K05866] [EC:3.1.3.48]
115204425  M-phase inducer phosphatase 1-B-like isoform X1 [KO:K05867] [EC:3.1.3.48]
115187902  14-3-3 protein beta/alpha-A-like [KO:K16197]
115187911  14-3-3 protein beta/alpha-A-like [KO:K16197]
115168462  14-3-3 protein beta/alpha-2 [KO:K16197]
115174979  14-3-3 protein zeta [KO:K16197]
115162527  14-3-3 protein beta/alpha-1-like [KO:K16197]
115166318  14-3-3 protein beta/alpha-2-like [KO:K16197]
115172823  14-3-3 protein zeta-like [KO:K16197]
115151089  ywhab; 14-3-3 protein beta/alpha [KO:K16197]
115195026  14-3-3 protein zeta-like [KO:K16197]
115208423  14-3-3 protein beta/alpha-1-like [KO:K16197]
115154109  14-3-3 protein epsilon isoform X1 [KO:K06630]
115163101  14-3-3 protein epsilon-like isoform X1 [KO:K06630]
115148621  14-3-3 protein epsilon-like isoform X1 [KO:K06630]
115206047  14-3-3 protein epsilon-like isoform X1 [KO:K06630]
115153901  14-3-3 protein gamma-1-like [KO:K16198]
115159467  14-3-3 protein eta-like [KO:K16198]
115163404  14-3-3 protein gamma-2 [KO:K16198]
115148437  14-3-3 protein gamma-1 [KO:K16198]
115206323  14-3-3 protein gamma-2-like [KO:K16198]
115204168  14-3-3 protein eta-like [KO:K16198]
115185196  plk1; serine/threonine-protein kinase PLK1 [KO:K06631] [EC:2.7.11.21]
115192812  wee1-like protein kinase 1-A [KO:K06632] [EC:2.7.11.1]
115167065  wee1-like protein kinase 1-A isoform X1 [KO:K06632] [EC:2.7.11.1]
115203256  wee1-like protein kinase 1-A [KO:K06632] [EC:2.7.11.1]
115197066  wee1-like protein kinase 1-A [KO:K06632] [EC:2.7.11.1]
115197422  wee1-like protein kinase 2 [KO:K06632] [EC:2.7.11.1]
115162173  pkmyt1; membrane-associated tyrosine- and threonine-specific cdc2-inhibitory kinase isoform X1 [KO:K06633] [EC:2.7.11.1]
115199766  ccnh; cyclin-H isoform X1 [KO:K06634]
115164393  cdk7; cyclin-dependent kinase 7 [KO:K02202] [EC:2.7.11.22 2.7.11.23]
115153320  anaphase-promoting complex subunit 1-like isoform X1 [KO:K03348]
115159591  anaphase-promoting complex subunit 2-like [KO:K03349]
115204046  anaphase-promoting complex subunit 2-like [KO:K03349]
115170940  cell division cycle protein 27 homolog isoform X1 [KO:K03350]
115196412  cell division cycle protein 27 homolog isoform X1 [KO:K03350]
115158508  anapc4; anaphase-promoting complex subunit 4 isoform X1 [KO:K03351]
115200012  anapc5; anaphase-promoting complex subunit 5 [KO:K03352]
115160605  cell division cycle protein 16 homolog isoform X1 [KO:K03353]
115156222  cell division cycle protein 16 homolog isoform X1 [KO:K03353]
115164667  anaphase-promoting complex subunit 7-like [KO:K03354]
115199969  anapc7; anaphase-promoting complex subunit 7 [KO:K03354]
115154817  cell division cycle protein 23 homolog [KO:K03355]
115204429  cell division cycle protein 23 homolog [KO:K03355]
115194734  anapc10; anaphase-promoting complex subunit 10 [KO:K03357]
115177593  anaphase-promoting complex subunit 11 [KO:K03358]
115208656  anaphase-promoting complex subunit 11-like [KO:K03358]
115159715  anaphase-promoting complex subunit CDC26-like isoform X1 [KO:K03359]
115203956  cdc26; anaphase-promoting complex subunit CDC26 [KO:K03359]
115148692  anapc13; anaphase-promoting complex subunit 13 [KO:K12456]
115163715  anaphase-promoting complex subunit 15-like isoform X1 [KO:K25228]
115206593  anapc15; anaphase-promoting complex subunit 15 isoform X1 [KO:K25228]
115152741  anapc16; anaphase-promoting complex subunit 16 [KO:K25229]
115165028  cdc20b; cell division cycle protein 20 homolog B isoform X1 [KO:K03363]
115169683  cell division cycle protein 20 homolog [KO:K03363]
115205058  securin-like [KO:K06635]
115207813  espl1; separin isoform X1 [KO:K02365] [EC:3.4.22.49]
115167824  structural maintenance of chromosomes protein 1A [KO:K06636]
115165483  structural maintenance of chromosomes protein 1A-like [KO:K06636]
115197583  structural maintenance of chromosomes protein 1B-like [KO:K06636]
115178801  structural maintenance of chromosomes protein 3 [KO:K06669]
115147376  structural maintenance of chromosomes protein 3 [KO:K06669]
115168062  double-strand-break repair protein rad21 homolog isoform X1 [KO:K06670]
115187876  double-strand-break repair protein rad21 homolog A-like [KO:K06670]
115187877  double-strand-break repair protein rad21 homolog A-like [KO:K06670]
115165723  double-strand-break repair protein rad21 homolog isoform X1 [KO:K06670]
115173411  double-strand-break repair protein rad21 homolog A-like [KO:K06670]
115168018  cohesin subunit SA-2-like [KO:K06671]
115183340  cohesin subunit SA-1 [KO:K06671]
115169487  cohesin subunit SA-2-like isoform X1 [KO:K06671]
115154456  cohesin subunit SA-2 [KO:K06671]
115156216  cohesin subunit SA-2-like isoform X1 [KO:K06671]
115148998  cohesin subunit SA-2-like [KO:K06671]
115196215  LOW QUALITY PROTEIN: cohesin subunit SA-1-like [KO:K06671]
115205649  cohesin subunit SA-2-like [KO:K06671]
115183766  transcriptional regulator ATRX-like [KO:K10779]
115154510  transcriptional regulator ATRX-like [KO:K10779]
115163822  LOW QUALITY PROTEIN: transcriptional regulator ATRX-like [KO:K10779]
115149048  transcriptional regulator ATRX-like [KO:K10779]
115196695  ddx11; ATP-dependent DNA helicase DDX11 [KO:K11273] [EC:5.6.2.7]
115164998  nipped-B-like protein B [KO:K06672]
115159352  nipped-B-like protein isoform X1 [KO:K06672]
115149228  nipped-B-like protein B isoform X1 [KO:K06672]
115169367  MAU2 chromatid cohesion factor homolog isoform X1 [KO:K11266]
115158206  MAU2 chromatid cohesion factor homolog isoform X1 [KO:K11266]
115157428  MAU2 chromatid cohesion factor homolog isoform X1 [KO:K11266]
115151798  mau2; MAU2 chromatid cohesion factor homolog isoform X1 [KO:K11266]
115198595  hdac8; histone deacetylase 8 [KO:K11405] [EC:3.5.1.98]
115192795  esco2; N-acetyltransferase ESCO2 [KO:K11268] [EC:2.3.1.-]
115174800  N-acetyltransferase ESCO2-like [KO:K11268] [EC:2.3.1.-]
115204626  pds5b; sister chromatid cohesion protein PDS5 homolog B isoform X1 [KO:K11267]
115157523  wings apart-like protein homolog [KO:K25163]
115193699  wings apart-like protein homolog isoform X1 [KO:K25163]
115153256  wings apart-like protein homolog [KO:K25163]
115201129  wings apart-like protein homolog isoform X1 [KO:K25163]
115154694  sororin-like [KO:K17390]
115204301  cdca5; sororin [KO:K17390]
115152346  aurora kinase B-like [KO:K11479] [EC:2.7.11.1]
115197586  aurora kinase B-like [KO:K11479] [EC:2.7.11.1]
115173977  shugoshin 1-like isoform X1 [KO:K11580]
115154024  serine/threonine-protein phosphatase 2A catalytic subunit alpha isoform-like isoform X1 [KO:K04382] [EC:3.1.3.16]
115160075  serine/threonine-protein phosphatase 2A catalytic subunit beta isoform [KO:K04382] [EC:3.1.3.16]
115167379  serine/threonine-protein phosphatase 2A catalytic subunit alpha isoform-like [KO:K04382] [EC:3.1.3.16]
115167649  serine/threonine-protein phosphatase 2A catalytic subunit alpha isoform-like isoform X1 [KO:K04382] [EC:3.1.3.16]
115148561  serine/threonine-protein phosphatase 2A catalytic subunit alpha isoform-like [KO:K04382] [EC:3.1.3.16]
115203777  serine/threonine-protein phosphatase 2A catalytic subunit beta isoform [KO:K04382] [EC:3.1.3.16]
115205700  serine/threonine-protein phosphatase 2A catalytic subunit alpha isoform-like isoform X1 [KO:K04382] [EC:3.1.3.16]
115162918  serine/threonine-protein phosphatase 2A 65 kDa regulatory subunit A beta isoform-like [KO:K03456]
115205876  serine/threonine-protein phosphatase 2A 65 kDa regulatory subunit A beta isoform [KO:K03456]
115193894  serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit delta isoform-like isoform X1 [KO:K11584]
115168369  serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit gamma isoform-like isoform X1 [KO:K11584]
115174524  serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit gamma isoform-like isoform X1 [KO:K11584]
115153103  serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit delta isoform [KO:K11584]
115175014  serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit alpha isoform-like [KO:K11584]
115162235  serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit epsilon isoform-like [KO:K11584]
115162656  serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit gamma isoform isoform X1 [KO:K11584]
115172518  serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit epsilon isoform isoform X1 [KO:K11584]
115172902  serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit gamma isoform-like isoform X1 [KO:K11584]
115195884  serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit alpha isoform-like isoform X1 [KO:K11584]
115198621  serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit beta isoform isoform X1 [KO:K11584]
115164996  kinetochore protein NDC80 homolog [KO:K11547]
115165004  kinetochore protein NDC80 homolog [KO:K11547]
115165097  kinetochore protein NDC80 homolog [KO:K11547]
115174708  knl1; kinetochore scaffold 1 [KO:K11542]
115175934  dual specificity protein kinase Ttk-like [KO:K08866] [EC:2.7.12.1]
115177371  dual specificity protein kinase Ttk-like [KO:K08866] [EC:2.7.12.1]
115178485  mitotic spindle assembly checkpoint protein MAD1-like [KO:K06679]
115147910  mitotic spindle assembly checkpoint protein MAD1-like [KO:K06679]
115194121  mitotic spindle assembly checkpoint protein MAD2A-like [KO:K02537]
115198132  mitotic spindle assembly checkpoint protein MAD2A-like [KO:K02537]
115168171  mad2l2; mitotic spindle assembly checkpoint protein MAD2B isoform X1 [KO:K13728]
115172676  mitotic checkpoint serine/threonine-protein kinase BUB1 beta-like [KO:K06637] [EC:2.7.11.1]
115190114  mitotic checkpoint protein BUB3-like [KO:K02180]
115190115  bub3; mitotic checkpoint protein BUB3 isoform X1 [KO:K02180]
115174940  mitotic checkpoint serine/threonine-protein kinase BUB1-like isoform X1 [KO:K02178] [EC:2.7.11.1]
115194477  mitotic checkpoint serine/threonine-protein kinase BUB1-like isoform X1 [KO:K02178] [EC:2.7.11.1]
115187610  pachytene checkpoint protein 2 homolog [KO:K22399]
115187611  pachytene checkpoint protein 2 homolog [KO:K22399]
115153548  mad2l1bp; MAD2L1-binding protein isoform X1 [KO:K26093]
115169408  fizzy-related protein homolog [KO:K03364]
115158407  fizzy-related protein homolog isoform X1 [KO:K03364]
115157255  fizzy-related protein homolog [KO:K03364]
115157414  fizzy-related protein homolog [KO:K03364]
115153323  F-box only protein 5-like [KO:K10292]
115158065  dual specificity protein phosphatase CDC14AB-like isoform X1 [KO:K06639] [EC:3.1.3.16 3.1.3.48]
115164192  dual specificity protein phosphatase CDC14C-like isoform X1 [KO:K06639] [EC:3.1.3.16 3.1.3.48]
115156830  dual specificity protein phosphatase CDC14AB-like isoform X1 [KO:K06639] [EC:3.1.3.16 3.1.3.48]
115151628  dual specificity protein phosphatase CDC14AB-like isoform X1 [KO:K06639] [EC:3.1.3.16 3.1.3.48]
115200451  dual specificity protein phosphatase CDC14C-like isoform X1 [KO:K06639] [EC:3.1.3.16 3.1.3.48]
115152698  histone acetyltransferase p300-like [KO:K04498] [EC:2.3.1.48]
115171283  histone acetyltransferase p300-like isoform X1 [KO:K04498] [EC:2.3.1.48]
115171774  CREB-binding protein-like isoform X1 [KO:K04498] [EC:2.3.1.48]
115178827  CREB-binding protein-like isoform X1 [KO:K04498] [EC:2.3.1.48]
115147398  CREB-binding protein-like isoform X1 [KO:K04498] [EC:2.3.1.48]
115206430  CREB-binding protein-like isoform X1 [KO:K04498] [EC:2.3.1.48]
115201319  histone acetyltransferase p300-like isoform X1 [KO:K04498] [EC:2.3.1.48]
115199931  histone acetyltransferase p300-like [KO:K04498] [EC:2.3.1.48]
115150674  prkdc; DNA-dependent protein kinase catalytic subunit [KO:K06642] [EC:2.7.11.1]
115196220  LOW QUALITY PROTEIN: serine/threonine-protein kinase ATR-like [KO:K06640] [EC:2.7.11.1]
115206406  atm; serine-protein kinase ATM isoform X1 [KO:K04728] [EC:2.7.11.1]
115182075  E3 ubiquitin-protein ligase Mdm2-like isoform X1 [KO:K06643] [EC:2.3.2.27]
115182930  E3 ubiquitin-protein ligase Mdm2-like isoform X1 [KO:K06643] [EC:2.3.2.27]
115154926  cellular tumor antigen p53 [KO:K04451]
115194175  cellular tumor antigen p53-like [KO:K04451]
115198177  cellular tumor antigen p53-like isoform X1 [KO:K04451]
115192326  growth arrest and DNA damage-inducible protein GADD45 alpha-like [KO:K04402]
115158081  growth arrest and DNA damage-inducible protein GADD45 beta-like [KO:K04402]
115169986  growth arrest and DNA damage-inducible protein GADD45 alpha-like [KO:K04402]
115158595  growth arrest and DNA damage-inducible protein GADD45 alpha-like isoform X1 [KO:K04402]
115160226  growth arrest and DNA damage-inducible protein GADD45 gamma-like [KO:K04402]
115160227  growth arrest and DNA damage-inducible protein GADD45 gamma-like [KO:K04402]
115164187  growth arrest and DNA damage-inducible protein GADD45 gamma-like [KO:K04402]
115156711  growth arrest and DNA damage-inducible protein GADD45 alpha-like [KO:K04402]
115151646  growth arrest and DNA damage-inducible protein GADD45 beta-like [KO:K04402]
115200447  growth arrest and DNA damage-inducible protein GADD45 gamma-like [KO:K04402]
115202749  growth arrest and DNA damage-inducible protein GADD45 gamma-like [KO:K04402]
115202750  growth arrest and DNA damage-inducible protein GADD45 gamma-like [KO:K04402]
115164335  proliferating cell nuclear antigen [KO:K04802]
115200315  proliferating cell nuclear antigen-like [KO:K04802]
115204711  chek1; serine/threonine-protein kinase Chk1 [KO:K02216] [EC:2.7.11.1]
115164873  serine/threonine-protein kinase Chk2-like isoform X1 [KO:K06641] [EC:2.7.11.1]
115199789  serine/threonine-protein kinase Chk2-like [KO:K06641] [EC:2.7.11.1]
Reference
PMID:7908906
  Authors
Matsuoka S, Yamaguchi M, Matsukage A
  Title
D-type cyclin-binding regions of proliferating cell nuclear antigen.
  Journal
J Biol Chem 269:11030-6 (1994)
Reference
PMID:8242749
  Authors
Welch PJ, Wang JY
  Title
A C-terminal protein-binding domain in the retinoblastoma protein regulates nuclear c-Abl tyrosine kinase in the cell cycle.
  Journal
Cell 75:779-90 (1993)
DOI:10.1016/0092-8674(93)90497-E
Reference
PMID:16936746
  Authors
Macaluso M, Montanari M, Giordano A
  Title
Rb family proteins as modulators of gene expression and new aspects regarding the interaction with chromatin remodeling enzymes.
  Journal
Oncogene 25:5263-7 (2006)
DOI:10.1038/sj.onc.1209680
Reference
PMID:15838516
  Authors
Cobrinik D
  Title
Pocket proteins and cell cycle control.
  Journal
Oncogene 24:2796-809 (2005)
DOI:10.1038/sj.onc.1208619
Reference
PMID:17568790
  Authors
Boutros R, Lobjois V, Ducommun B
  Title
CDC25 phosphatases in cancer cells: key players? Good targets?
  Journal
Nat Rev Cancer 7:495-507 (2007)
DOI:10.1038/nrc2169
Reference
PMID:9832503
  Authors
Diehl JA, Cheng M, Roussel MF, Sherr CJ
  Title
Glycogen synthase kinase-3beta regulates cyclin D1 proteolysis and subcellular localization.
  Journal
Genes Dev 12:3499-511 (1998)
DOI:10.1101/gad.12.22.3499
Reference
PMID:19020303
  Authors
Klein EA, Assoian RK
  Title
Transcriptional regulation of the cyclin D1 gene at a glance.
  Journal
J Cell Sci 121:3853-7 (2008)
DOI:10.1242/jcs.039131
Reference
PMID:10385618
  Authors
Sherr CJ, Roberts JM
  Title
CDK inhibitors: positive and negative regulators of G1-phase progression.
  Journal
Genes Dev 13:1501-12 (1999)
DOI:10.1101/gad.13.12.1501
Reference
PMID:12809600
  Authors
Shi Y, Massague J.
  Title
Mechanisms of TGF-beta signaling from cell membrane to the nucleus.
  Journal
Cell 113:685-700 (2003)
DOI:10.1016/S0092-8674(03)00432-X
Reference
PMID:12925736
  Authors
Kamura T, Hara T, Kotoshiba S, Yada M, Ishida N, Imaki H, Hatakeyama S, Nakayama K, Nakayama KI
  Title
Degradation of p57Kip2 mediated by SCFSkp2-dependent ubiquitylation.
  Journal
Proc Natl Acad Sci U S A 100:10231-6 (2003)
DOI:10.1073/pnas.1831009100
Reference
PMID:16212951
  Authors
Bond M, Sala-Newby GB, Wu YJ, Newby AC
  Title
Biphasic effect of p21Cip1 on smooth muscle cell proliferation: role of PI 3-kinase and Skp2-mediated degradation.
  Journal
Cardiovasc Res 69:198-206 (2006)
DOI:10.1016/j.cardiores.2005.08.020
Reference
PMID:15838523
  Authors
Harris SL, Levine AJ.
  Title
The p53 pathway: positive and negative feedback loops.
  Journal
Oncogene 24:2899-908 (2005)
DOI:10.1038/sj.onc.1208615
Reference
PMID:11099028
  Authors
Vogelstein B, Lane D, Levine AJ
  Title
Surfing the p53 network.
  Journal
Nature 408:307-10 (2000)
DOI:10.1038/35042675
Reference
PMID:7973727
  Authors
Smith ML, Chen IT, Zhan Q, Bae I, Chen CY, Gilmer TM, Kastan MB, O'Connor PM, Fornace AJ Jr
  Title
Interaction of the p53-regulated protein Gadd45 with proliferating cell nuclear antigen.
  Journal
Science 266:1376-80 (1994)
DOI:10.1126/science.7973727
Reference
PMID:9889196
  Authors
Petersen BO, Lukas J, Sorensen CS, Bartek J, Helin K
  Title
Phosphorylation of mammalian CDC6 by cyclin A/CDK2 regulates its subcellular localization.
  Journal
EMBO J 18:396-410 (1999)
DOI:10.1093/emboj/18.2.396
Reference
PMID:17018296
  Authors
Sheu YJ, Stillman B
  Title
Cdc7-Dbf4 phosphorylates MCM proteins via a docking site-mediated mechanism to promote S phase progression.
  Journal
Mol Cell 24:101-13 (2006)
DOI:10.1016/j.molcel.2006.07.033
Reference
PMID:9029154
  Authors
Martinez AM, Afshar M, Martin F, Cavadore JC, Labbe JC, Doree M
  Title
Dual phosphorylation of the T-loop in cdk7: its role in controlling cyclin H binding and CAK activity.
  Journal
EMBO J 16:343-54 (1997)
DOI:10.1093/emboj/16.2.343
Reference
PMID:15876871
  Authors
Lolli G, Johnson LN
  Title
CAK-Cyclin-dependent Activating Kinase: a key kinase in cell cycle control and a target for drugs?
  Journal
Cell Cycle 4:572-7 (2005)
DOI:10.4161/cc.4.4.1607
Reference
PMID:17426725
  Authors
Musacchio A, Salmon ED
  Title
The spindle-assembly checkpoint in space and time.
  Journal
Nat Rev Mol Cell Biol 8:379-93 (2007)
DOI:10.1038/nrm2163
Reference
PMID:12573239
  Authors
Uhlmann F
  Title
Chromosome cohesion and separation: from men and molecules.
  Journal
Curr Biol 13:R104-14 (2003)
DOI:10.1016/S0960-9822(03)00039-3
Reference
PMID:15568976
  Authors
Stegmeier F, Amon A
  Title
Closing mitosis: the functions of the Cdc14 phosphatase and its regulation.
  Journal
Annu Rev Genet 38:203-32 (2004)
DOI:10.1146/annurev.genet.38.072902.093051
Reference
PMID:9618481
  Authors
Moustakas A, Kardassis D
  Title
Regulation of the human p21/WAF1/Cip1 promoter in hepatic cells by functional interactions between Sp1 and Smad family members.
  Journal
Proc Natl Acad Sci U S A 95:6733-8 (1998)
DOI:10.1073/pnas.95.12.6733
Reference
PMID:26650195
  Authors
de Boer HR, Guerrero Llobet S, van Vugt MA
  Title
Controlling the response to DNA damage by the APC/C-Cdh1.
  Journal
Cell Mol Life Sci 73:949-60 (2016)
DOI:10.1007/s00018-015-2096-7
Reference
PMID:20935501
  Authors
Qiao X, Zhang L, Gamper AM, Fujita T, Wan Y
  Title
APC/C-Cdh1: from cell cycle to cellular differentiation and genomic integrity.
  Journal
Cell Cycle 9:3904-12 (2010)
DOI:10.4161/cc.9.19.13585
Related
pathway
stru03030  DNA replication
stru04010  MAPK signaling pathway
stru04120  Ubiquitin mediated proteolysis
stru04210  Apoptosis
KO pathway
ko04110   
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