KEGG   PATHWAY: pcoo04020
Entry
pcoo04020                   Pathway                                
Name
Calcium signaling pathway - Puma concolor (puma)
Description
Ca2+ that enters the cell from the outside is a principal source of signal Ca2+. Entry of Ca2+ is driven by the presence of a large electrochemical gradient across the plasma membrane. Cells use this external source of signal Ca2+ by activating various entry channels with widely different properties. The voltage-operated channels (VOCs) are found in excitable cells and generate the rapid Ca2+ fluxes that control fast cellular processes. There are many other Ca2+-entry channels, such as the receptor-operated channels (ROCs), for example the NMDA (N-methyl-D-aspartate) receptors (NMDARs) that respond to glutamate. There also are second-messenger-operated channels (SMOCs) and store-operated channels (SOCs).
The other principal source of Ca2+ for signalling is the internal stores that are located primarily in the endoplasmic/sarcoplasmic reticulum (ER/SR), in which inositol-1,4,5-trisphosphate receptors (IP3Rs) or ryanodine receptors (RYRs) regulate the release of Ca2+. The principal activator of these channels is Ca2+ itself and this process of Ca2+-induced Ca2+ release is central to the mechanism of Ca2+ signalling. Various second messengers or modulators also control the release of Ca2+. IP3, which is generated by pathways using different isoforms of phospholipase C (PLCbeta, delta, epsilon, gamma and zeta), regulates the IP3Rs. Cyclic ADP-ribose (cADPR) releases Ca2+ via RYRs. Nicotinic acid adenine dinucleotide phosphate (NAADP) may activate a distinct Ca2+ release mechanism on separate acidic Ca2+ stores. Ca2+ release via the NAADP-sensitive mechanism may also feedback onto either RYRs or IP3Rs. cADPR and NAADP are generated by CD38. This enzyme might be sensitive to the cellular metabolism, as ATP and NADH inhibit it.
The influx of Ca2+ from the environment or release from internal stores causes a very rapid and dramatic increase in cytoplasmic calcium concentration, which has been widely exploited for signal transduction. Some proteins, such as troponin C (TnC) involved in muscle contraction, directly bind to and sense Ca2+. However, in other cases Ca2+ is sensed through intermediate calcium sensors such as calmodulin (CALM).
Class
Environmental Information Processing; Signal transduction
Pathway map
pcoo04020  Calcium signaling pathway
pcoo04020

Other DBs
GO: 0019722
Organism
Puma concolor (puma) [GN:pcoo]
Gene
112855210  SLC8A3; sodium/calcium exchanger 3 isoform X1 [KO:K05849]
112864402  SLC8A1; sodium/calcium exchanger 1 isoform X1 [KO:K05849]
112863605  ATP2B1; plasma membrane calcium-transporting ATPase 1 [KO:K05850] [EC:7.2.2.10]
112870593  ATP2B3; plasma membrane calcium-transporting ATPase 3 isoform X1 [KO:K05850] [EC:7.2.2.10]
112857904  ATP2B4; plasma membrane calcium-transporting ATPase 4 isoform X1 [KO:K05850] [EC:7.2.2.10]
112858784  ATP2B2; plasma membrane calcium-transporting ATPase 2 isoform X1 [KO:K05850] [EC:7.2.2.10]
112852113  CHRM1; muscarinic acetylcholine receptor M1 [KO:K04129]
112851546  CHRM3; muscarinic acetylcholine receptor M3 [KO:K04131]
112856055  CHRM5; muscarinic acetylcholine receptor M5 [KO:K04133]
112870511  ADORA2A; adenosine receptor A2a isoform X1 [KO:K04266]
112857131  ADORA2B; adenosine receptor A2b [KO:K04267]
112861314  ADRB2; beta-2 adrenergic receptor [KO:K04142]
112858503  ADRB3; beta-3 adrenergic receptor [KO:K04143]
112861354  DRD1; D(1A) dopamine receptor [KO:K04144]
112858622  DRD5; D(1B) dopamine receptor [KO:K05840]
112861504  HRH2; histamine H2 receptor [KO:K04150]
112860481  HTR4; 5-hydroxytryptamine receptor 4 [KO:K04160]
112866984  HTR5A; 5-hydroxytryptamine receptor 5A [KO:K04161]
112848675  HTR6; 5-hydroxytryptamine receptor 6 [KO:K04162]
112854627  HTR7; 5-hydroxytryptamine receptor 7 [KO:K04163]
112869078  guanine nucleotide-binding protein G(s) subunit alpha-like [KO:K04632]
112869430  neuroendocrine secretory protein 55 [KO:K04632]
112868351  GNAL; guanine nucleotide-binding protein G(olf) subunit alpha [KO:K04633]
112859788  ADCY1; adenylate cyclase type 1 [KO:K08041] [EC:4.6.1.1]
112860207  ADCY2; adenylate cyclase type 2 [KO:K08042] [EC:4.6.1.1]
112864041  ADCY3; adenylate cyclase type 3 isoform X1 [KO:K08043] [EC:4.6.1.1]
112855238  ADCY4; adenylate cyclase type 4 [KO:K08044] [EC:4.6.1.1]
112857348  ADCY7; adenylate cyclase type 7 [KO:K08047] [EC:4.6.1.1]
112859389  ADCY8; adenylate cyclase type 8 [KO:K08048] [EC:4.6.1.1]
112853291  ADCY9; adenylate cyclase type 9 [KO:K08049] [EC:4.6.1.1]
112852313  PRKACA; cAMP-dependent protein kinase catalytic subunit alpha [KO:K04345] [EC:2.7.11.11]
112871920  PRKACB; cAMP-dependent protein kinase catalytic subunit beta isoform X1 [KO:K04345] [EC:2.7.11.11]
112862106  PLN; cardiac phospholamban [KO:K05852]
112866098  SLN; sarcolipin [KO:K22642]
112854890  MRLN; LOW QUALITY PROTEIN: myoregulin [KO:K22643]
112858024  CUNH4orf3; uncharacterized protein C4orf3 homolog isoform X1 [KO:K26467]
112856468  ATP2A1; sarcoplasmic/endoplasmic reticulum calcium ATPase 1 [KO:K05853] [EC:7.2.2.10]
112870208  ATP2A2; sarcoplasmic/endoplasmic reticulum calcium ATPase 2 isoform X1 [KO:K05853] [EC:7.2.2.10]
112852269  ATP2A3; sarcoplasmic/endoplasmic reticulum calcium ATPase 3 isoform X1 [KO:K05853] [EC:7.2.2.10]
112850797  HRC; sarcoplasmic reticulum histidine-rich calcium-binding protein [KO:K23450]
112865132  STIM1; stromal interaction molecule 1 isoform X1 [KO:K16059]
112858375  STIM2; LOW QUALITY PROTEIN: stromal interaction molecule 2 [KO:K18196]
112870113  ORAI1; calcium release-activated calcium channel protein 1 [KO:K16056]
112857396  ORAI3; protein orai-3 isoform X1 [KO:K16058]
112867221  CACNA1C; voltage-dependent L-type calcium channel subunit alpha-1C [KO:K04850]
112852481  CACNA1D; voltage-dependent L-type calcium channel subunit alpha-1D [KO:K04851]
112871144  CACNA1F; voltage-dependent L-type calcium channel subunit alpha-1F isoform X1 [KO:K04853]
112857700  CACNA1S; LOW QUALITY PROTEIN: voltage-dependent L-type calcium channel subunit alpha-1S [KO:K04857]
112852304  CACNA1A; LOW QUALITY PROTEIN: voltage-dependent P/Q-type calcium channel subunit alpha-1A [KO:K04344]
112860864  CACNA1B; voltage-dependent N-type calcium channel subunit alpha-1B [KO:K04849]
112857627  CACNA1E; voltage-dependent R-type calcium channel subunit alpha-1E isoform X1 [KO:K04852]
112852574  CACNA1G; LOW QUALITY PROTEIN: voltage-dependent T-type calcium channel subunit alpha-1G [KO:K04854]
112863441  CACNA1I; LOW QUALITY PROTEIN: voltage-dependent T-type calcium channel subunit alpha-1I [KO:K04856]
112856150  CHRNA7; LOW QUALITY PROTEIN: neuronal acetylcholine receptor subunit alpha-7 [KO:K04809]
112853155  GRIN2A; glutamate receptor ionotropic, NMDA 2A [KO:K05209]
112867262  GRIN2B; glutamate receptor ionotropic, NMDA 2B [KO:K05210]
112861457  GRIN3A; glutamate receptor ionotropic, NMDA 3A [KO:K05213]
112853655  P2RX1; P2X purinoceptor 1 isoform X1 [KO:K05215]
112865111  P2RX3; P2X purinoceptor 3 [KO:K05217]
112870126  P2RX4; P2X purinoceptor 4 [KO:K05218]
112852702  P2RX5; P2X purinoceptor 5 [KO:K05219]
112870214  P2RX6; P2X purinoceptor 6 [KO:K05221]
112870235  P2RX7; P2X purinoceptor 7 [KO:K05220]
112851287  RYR1; ryanodine receptor 1 [KO:K04961]
112851518  RYR2; ryanodine receptor 2 [KO:K04962]
112855628  RYR3; LOW QUALITY PROTEIN: ryanodine receptor 3 [KO:K04963]
112862427  TRDN; triadin [KO:K23449]
112851752  CASQ1; calsequestrin-1 [KO:K23468]
112871745  CASQ2; calsequestrin-2 [KO:K23445]
112859558  ASPH; LOW QUALITY PROTEIN: aspartyl/asparaginyl beta-hydroxylase [KO:K00476] [EC:1.14.11.16]
112870601  CYSLTR1; cysteinyl leukotriene receptor 1 [KO:K04322]
112861251  CYSLTR2; cysteinyl leukotriene receptor 2 [KO:K04323]
112866732  CHRM2; muscarinic acetylcholine receptor M2 [KO:K04130]
112869901  ADRA1A; alpha-1A adrenergic receptor [KO:K04135]
112860507  ADRA1B; alpha-1B adrenergic receptor [KO:K04136]
112849615  AGTR1; type-1 angiotensin II receptor [KO:K04166]
112858109  EDNRA; endothelin-1 receptor isoform X1 [KO:K04197]
112861085  EDNRB; LOW QUALITY PROTEIN: endothelin receptor type B [KO:K04198]
112861690  F2R; proteinase-activated receptor 1 [KO:K03914]
112862043  GRM1; metabotropic glutamate receptor 1 isoform X1 [KO:K04603]
112865771  GRM5; metabotropic glutamate receptor 5 [KO:K04604]
112871686  GRPR; gastrin-releasing peptide receptor [KO:K04169]
112858941  HRH1; histamine H1 receptor [KO:K04149]
112870890  HTR2C; 5-hydroxytryptamine receptor 2C [KO:K04157]
112872150  HTR2B; 5-hydroxytryptamine receptor 2B [KO:K04157]
112861157  HTR2A; 5-hydroxytryptamine receptor 2A [KO:K04157]
112868946  LHCGR; lutropin-choriogonadotropic hormone receptor [KO:K04248]
112869051  NTSR1; neurotensin receptor type 1 [KO:K04211]
112858498  OXTR; oxytocin receptor [KO:K04229]
112863837  AVPR1A; vasopressin V1a receptor [KO:K04226]
112857851  AVPR1B; vasopressin V1b receptor [KO:K04227]
112856366  LTB4R2; leukotriene B4 receptor 2 [KO:K04297]
112872233  PTAFR; platelet-activating factor receptor [KO:K04279]
112868296  PTGER3; prostaglandin E2 receptor EP3 subtype isoform X1 [KO:K04260]
112848676  PTGFR; prostaglandin F2-alpha receptor isoform X1 [KO:K04262]
112855876  BDKRB1; B1 bradykinin receptor [KO:K03915]
112856307  BDKRB2; B2 bradykinin receptor [KO:K03916]
112869113  TACR1; substance-P receptor [KO:K04222]
112854635  TACR2; substance-K receptor [KO:K04223]
112858370  TACR3; neuromedin-K receptor [KO:K04224]
112869464  thyrotropin-releasing hormone receptor-like [KO:K04282]
112859590  TRHR; thyrotropin-releasing hormone receptor [KO:K04282]
112858367  CCKAR; cholecystokinin receptor type A [KO:K04194]
112865539  CCKBR; gastrin/cholecystokinin type B receptor isoform X1 [KO:K04195]
112848859  CXCR4; C-X-C chemokine receptor type 4 [KO:K04189]
112868673  guanine nucleotide-binding protein G(q) subunit alpha isoform X1 [KO:K04634]
112868631  GNA14; guanine nucleotide-binding protein subunit alpha-14 [KO:K04636]
112852816  GNA15; guanine nucleotide-binding protein subunit alpha-15 [KO:K04637]
112858016  EGF; pro-epidermal growth factor isoform X1 [KO:K04357]
112869672  TGFA; protransforming growth factor alpha [KO:K08774]
112863445  PDGFB; platelet-derived growth factor subunit B [KO:K17386]
112858328  PDGFC; platelet-derived growth factor C [KO:K05450]
112865896  PDGFD; platelet-derived growth factor D [KO:K05450]
112861306  FGF1; fibroblast growth factor 1 isoform X1 [KO:K18496]
112855096  FGF7; fibroblast growth factor 7 [KO:K04358]
112869913  FGF20; fibroblast growth factor 20 [KO:K04358]
112869983  FGF17; fibroblast growth factor 17 isoform X1 [KO:K04358]
112870825  FGF16; fibroblast growth factor 16 [KO:K04358]
112858559  FGF5; fibroblast growth factor 5 isoform X1 [KO:K04358]
112860871  FGF9; fibroblast growth factor 9 [KO:K04358]
112867668  FGF6; fibroblast growth factor 6 [KO:K04358]
112851220  FGF21; fibroblast growth factor 21 [KO:K22429]
112867914  FGF23; fibroblast growth factor 23 [KO:K22428]
112862794  VEGFA; vascular endothelial growth factor A [KO:K05448]
112851906  VEGFB; vascular endothelial growth factor B [KO:K16858]
112869936  VEGFC; vascular endothelial growth factor C [KO:K05449]
112871693  VEGFD; vascular endothelial growth factor D [KO:K05449]
112872060  NGF; beta-nerve growth factor [KO:K02582]
112866583  HGF; hepatocyte growth factor isoform X1 [KO:K05460]
112852453  MST1; hepatocyte growth factor-like protein [KO:K23441]
112861270  GDNF; glial cell line-derived neurotrophic factor isoform X1 [KO:K05452]
112860068  EGFR; epidermal growth factor receptor [KO:K04361] [EC:2.7.10.1]
112854095  ERBB2; receptor tyrosine-protein kinase erbB-2 [KO:K05083] [EC:2.7.10.1]
112863755  ERBB3; receptor tyrosine-protein kinase erbB-3 [KO:K05084] [EC:2.7.10.1]
112866849  ERBB4; receptor tyrosine-protein kinase erbB-4 [KO:K05085] [EC:2.7.10.1]
112858116  PDGFRA; platelet-derived growth factor receptor alpha isoform X1 [KO:K04363] [EC:2.7.10.1]
112860921  PDGFRB; platelet-derived growth factor receptor beta isoform X1 [KO:K05089] [EC:2.7.10.1]
112858029  FGFR1; fibroblast growth factor receptor 1 isoform X1 [KO:K04362] [EC:2.7.10.1]
112854765  FGFR2; fibroblast growth factor receptor 2 [KO:K05093] [EC:2.7.10.1]
112860952  FGFR4; fibroblast growth factor receptor 4 isoform X1 [KO:K05095] [EC:2.7.10.1]
112860856  FLT1; vascular endothelial growth factor receptor 1 [KO:K05096] [EC:2.7.10.1]
112860716  FLT4; vascular endothelial growth factor receptor 3 [KO:K05097] [EC:2.7.10.1]
112858053  KDR; vascular endothelial growth factor receptor 2 [KO:K05098] [EC:2.7.10.1]
112868641  NTRK2; BDNF/NT-3 growth factors receptor [KO:K04360] [EC:2.7.10.1]
112855467  NTRK3; NT-3 growth factor receptor [KO:K05101] [EC:2.7.10.1]
112866634  MET; hepatocyte growth factor receptor [KO:K05099] [EC:2.7.10.1]
112852655  MST1R; macrophage-stimulating protein receptor isoform X1 [KO:K05100] [EC:2.7.10.1]
112854345  RET; proto-oncogene tyrosine-protein kinase receptor Ret [KO:K05126] [EC:2.7.10.1]
112849616  PLCD1; 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase delta-1 isoform X1 [KO:K05857] [EC:3.1.4.11]
112853968  PLCD3; 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase delta-3 [KO:K05857] [EC:3.1.4.11]
112867017  PLCD4; 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase delta-4 [KO:K05857] [EC:3.1.4.11]
112855622  PLCB2; 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-2 [KO:K05858] [EC:3.1.4.11]
112869362  PLCB4; 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-4 [KO:K05858] [EC:3.1.4.11]
112869587  PLCB1; 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-1 [KO:K05858] [EC:3.1.4.11]
112851908  PLCB3; LOW QUALITY PROTEIN: 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-3 [KO:K05858] [EC:3.1.4.11]
112869500  PLCG1; 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1 [KO:K01116] [EC:3.1.4.11]
112857487  PLCG2; 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-2 [KO:K05859] [EC:3.1.4.11]
112854425  PLCE1; 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase epsilon-1 isoform X1 [KO:K05860] [EC:3.1.4.11]
112867620  PLCZ1; 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase zeta-1 [KO:K05861] [EC:3.1.4.11]
112858201  ITPR1; inositol 1,4,5-trisphosphate receptor type 1 isoform X1 [KO:K04958]
112867360  ITPR2; inositol 1,4,5-trisphosphate receptor type 2 [KO:K04959]
112862849  ITPR3; inositol 1,4,5-trisphosphate receptor type 3 [KO:K04960]
112858986  CD38; ADP-ribosyl cyclase/cyclic ADP-ribose hydrolase 1 [KO:K01242] [EC:3.2.2.6 2.4.99.20]
112870489  TPCN1; two pore calcium channel protein 1 [KO:K16896]
112852902  MCOLN1; LOW QUALITY PROTEIN: mucolipin-1 [KO:K04992]
112864176  MCOLN2; mucolipin-2 [KO:K04993]
112871827  MCOLN3; mucolipin-3 isoform X1 [KO:K04994]
112854508  MCU; calcium uniporter protein, mitochondrial [KO:K20858]
112861387  VDAC1; LOW QUALITY PROTEIN: voltage-dependent anion-selective channel protein 1 [KO:K05862]
112854800  VDAC2; voltage-dependent anion-selective channel protein 2 [KO:K15040]
112858617  VDAC3; voltage-dependent anion-selective channel protein 3 isoform X1 [KO:K15041]
112869897  SLC25A4; ADP/ATP translocase 1 [KO:K05863]
112870821  SLC25A5; ADP/ATP translocase 2 [KO:K05863]
112858372  SLC25A31; ADP/ATP translocase 4 [KO:K05863]
112871659  SLC25A6; ADP/ATP translocase 3 isoform X1 [KO:K05863]
112854251  PPIF; peptidyl-prolyl cis-trans isomerase F, mitochondrial [KO:K09565] [EC:5.2.1.8]
112852709  TNNC1; troponin C, slow skeletal and cardiac muscles [KO:K05865]
112868951  TNNC2; troponin C, skeletal muscle [KO:K12042]
112868964  CALM2; calmodulin-2 [KO:K02183]
112856098  calmodulin-like [KO:K02183]
112856351  CALML4; LOW QUALITY PROTEIN: calmodulin-like protein 4 [KO:K02183]
112850749  CALM3; calmodulin-3 [KO:K02183]
112867219  calmodulin-like protein 3 [KO:K02183]
112867742  calmodulin-like [KO:K02183]
112856054  PHKG2; phosphorylase b kinase gamma catalytic chain, liver/testis isoform [KO:K00871] [EC:2.7.11.19]
112860057  PHKG1; phosphorylase b kinase gamma catalytic chain, skeletal muscle/heart isoform isoform X1 [KO:K00871] [EC:2.7.11.19]
112857471  PHKB; phosphorylase b kinase regulatory subunit beta isoform X1 [KO:K07190]
112871214  PHKA1; phosphorylase b kinase regulatory subunit alpha, skeletal muscle isoform isoform X1 [KO:K07190]
112871583  PHKA2; phosphorylase b kinase regulatory subunit alpha, liver isoform isoform X1 [KO:K07190]
112849883  MYLK; myosin light chain kinase, smooth muscle [KO:K00907] [EC:2.7.11.18]
112869545  MYLK2; myosin light chain kinase 2, skeletal/cardiac muscle [KO:K00907] [EC:2.7.11.18]
112857385  MYLK3; myosin light chain kinase 3 [KO:K00907] [EC:2.7.11.18]
112857669  CAMK1G; calcium/calmodulin-dependent protein kinase type 1G [KO:K08794] [EC:2.7.11.17]
112859189  CAMK1; calcium/calmodulin-dependent protein kinase type 1 [KO:K08794] [EC:2.7.11.17]
112867205  CAMK1D; calcium/calmodulin-dependent protein kinase type 1D [KO:K08794] [EC:2.7.11.17]
112858645  CAMK2D; calcium/calmodulin-dependent protein kinase type II subunit delta isoform X1 [KO:K04515] [EC:2.7.11.17]
112859917  CAMK2B; calcium/calmodulin-dependent protein kinase type II subunit beta [KO:K04515] [EC:2.7.11.17]
112860328  CAMK2A; calcium/calmodulin-dependent protein kinase type II subunit alpha isoform X1 [KO:K04515] [EC:2.7.11.17]
112854376  CAMK2G; calcium/calmodulin-dependent protein kinase type II subunit gamma [KO:K04515] [EC:2.7.11.17]
112861108  CAMK4; calcium/calmodulin-dependent protein kinase type IV [KO:K05869] [EC:2.7.11.17]
112869884  PPP3CC; serine/threonine-protein phosphatase 2B catalytic subunit gamma isoform [KO:K04348] [EC:3.1.3.16]
112858792  PPP3CA; serine/threonine-protein phosphatase 2B catalytic subunit alpha isoform [KO:K04348] [EC:3.1.3.16]
112854258  PPP3CB; serine/threonine-protein phosphatase 2B catalytic subunit beta isoform isoform X1 [KO:K04348] [EC:3.1.3.16]
112861555  PPP3R2; calcineurin subunit B type 2 [KO:K06268]
112869328  PPP3R1; calcineurin subunit B type 1 [KO:K06268]
112862453  TFEB; transcription factor EB [KO:K15590]
112869109  NFATC2; nuclear factor of activated T-cells, cytoplasmic 2 [KO:K17332]
112857223  NFATC3; nuclear factor of activated T-cells, cytoplasmic 3 isoform X1 [KO:K17333]
112855706  NFATC4; nuclear factor of activated T-cells, cytoplasmic 4 [KO:K17334]
112870473  NOS1; nitric oxide synthase, brain [KO:K13240] [EC:1.14.13.39]
112855216  NOS2; nitric oxide synthase, inducible [KO:K13241] [EC:1.14.13.39]
112866504  NOS3; LOW QUALITY PROTEIN: nitric oxide synthase, endothelial [KO:K13242] [EC:1.14.13.39]
112848945  PDE1A; calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A isoform X1 [KO:K13755] [EC:3.1.4.17]
112866565  PDE1C; calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1C isoform X1 [KO:K13755] [EC:3.1.4.17]
112867441  PDE1B; calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1B [KO:K13755] [EC:3.1.4.17]
112858915  PTK2B; protein-tyrosine kinase 2-beta [KO:K05871] [EC:2.7.10.2]
112856159  ITPKA; inositol-trisphosphate 3-kinase A [KO:K00911] [EC:2.7.1.127]
112863138  ITPKB; inositol-trisphosphate 3-kinase B [KO:K00911] [EC:2.7.1.127]
112851174  ITPKC; inositol-trisphosphate 3-kinase C [KO:K00911] [EC:2.7.1.127]
112864470  PRKCA; LOW QUALITY PROTEIN: protein kinase C alpha type [KO:K02677] [EC:2.7.11.13]
112853117  PRKCB; protein kinase C beta type [KO:K19662] [EC:2.7.11.13]
112850908  PRKCG; protein kinase C gamma type [KO:K19663] [EC:2.7.11.13]
Compound
C00002  ATP
C00004  NADH
C00076  Calcium cation
C00165  Diacylglycerol
C00575  3',5'-Cyclic AMP
C01245  D-myo-Inositol 1,4,5-trisphosphate
C01330  Sodium cation
C06124  Sphingosine 1-phosphate
C11556  1-Phosphatidyl-1D-myo-inositol 3,5-bisphosphate
C13050  Cyclic ADP-ribose
C13051  Nicotinic acid adenine dinucleotide phosphate
Reference
PMID:12838335
  Authors
Berridge MJ, Bootman MD, Roderick HL.
  Title
Calcium signalling: dynamics, homeostasis and remodelling.
  Journal
Nat Rev Mol Cell Biol 4:517-29 (2003)
DOI:10.1038/nrm1155
Reference
PMID:11413485
  Authors
Berridge MJ, Lipp P, Bootman MD.
  Title
The versatility and universality of calcium signalling.
  Journal
Nat Rev Mol Cell Biol 1:11-21 (2000)
DOI:10.1038/35036035
Reference
PMID:15111104
  Authors
Wang MC, Dolphin A, Kitmitto A.
  Title
L-type voltage-gated calcium channels: understanding function through structure.
  Journal
FEBS Lett 564:245-50 (2004)
DOI:10.1016/S0014-5793(04)00253-4
Reference
PMID:11299192
  Authors
Ferrier GR, Howlett SE.
  Title
Cardiac excitation-contraction coupling: role of membrane potential in regulation of contraction.
  Journal
Am J Physiol Heart Circ Physiol 280:H1928-44 (2001)
DOI:10.1152/ajpheart.2001.280.5.H1928
Reference
PMID:11698232
  Authors
Keef KD, Hume JR, Zhong J.
  Title
Regulation of cardiac and smooth muscle Ca(2+) channels (Ca(V)1.2a,b) by protein kinases.
  Journal
Am J Physiol Cell Physiol 281:C1743-56 (2001)
DOI:10.1152/ajpcell.2001.281.6.C1743
Reference
PMID:8125957
  Authors
Hell JW, Appleyard SM, Yokoyama CT, Warner C, Catterall WA.
  Title
Differential phosphorylation of two size forms of the N-type calcium channel alpha 1 subunit which have different COOH termini.
  Journal
J Biol Chem 269:7390-6 (1994)
Reference
PMID:15000521
  Authors
Yunker AM.
  Title
Modulation and pharmacology of low voltage-activated ("T-Type") calcium channels.
  Journal
J Bioenerg Biomembr 35:577-98 (2003)
DOI:10.1023/B:JOBB.0000008025.65675.37
Reference
PMID:9149541
  Authors
Yakel JL.
  Title
Calcineurin regulation of synaptic function: from ion channels to transmitter release and gene transcription.
  Journal
Trends Pharmacol Sci 18:124-34 (1997)
DOI:10.1016/S0165-6147(97)01046-8
Reference
PMID:10997573
  Authors
Fukunaga K, Miyamoto E.
  Title
A working model of CaM kinase II activity in hippocampal long-term potentiation and memory.
  Journal
Neurosci Res 38:3-17 (2000)
DOI:10.1016/S0168-0102(00)00139-5
Reference
PMID:9235901
  Authors
Della Rocca GJ, van Biesen T, Daaka Y, Luttrell DK, Luttrell LM, Lefkowitz RJ.
  Title
Ras-dependent mitogen-activated protein kinase activation by G protein-coupled receptors. Convergence of Gi- and Gq-mediated pathways on calcium/calmodulin, Pyk2, and Src kinase.
  Journal
J Biol Chem 272:19125-32 (1997)
DOI:10.1074/jbc.272.31.19125
Reference
PMID:7861177
  Authors
Furuichi T, Mikoshiba K.
  Title
Inositol 1, 4, 5-trisphosphate receptor-mediated Ca2+ signaling in the brain.
  Journal
J Neurochem 64:953-60 (1995)
DOI:10.1046/j.1471-4159.1995.64030953.x
Reference
PMID:14572802
  Authors
Bruce JI, Straub SV, Yule DI.
  Title
Crosstalk between cAMP and Ca2+ signaling in non-excitable cells.
  Journal
Cell Calcium 34:431-44 (2003)
DOI:10.1016/S0143-4160(03)00150-7
Reference
PMID:10331643
  Authors
Lee HC, Munshi C, Graeff R.
  Title
Structures and activities of cyclic ADP-ribose, NAADP and their metabolic enzymes.
  Journal
Mol Cell Biochem 193:89-98 (1999)
DOI:10.1007/978-1-4419-8740-2_13
Reference
PMID:11080247
  Authors
Crompton M.
  Title
Mitochondrial intermembrane junctional complexes and their role in cell death.
  Journal
J Physiol 529 Pt 1:11-21 (2000)
DOI:10.1111/j.1469-7793.2000.00011.x
Reference
PMID:10508738
  Authors
Grewal SS, York RD, Stork PJ.
  Title
Extracellular-signal-regulated kinase signalling in neurons.
  Journal
Curr Opin Neurobiol 9:544-53 (1999)
DOI:10.1016/S0959-4388(99)00010-0
Reference
PMID:12972622
  Authors
Trushin SA, Pennington KN, Carmona EM, Asin S, Savoy DN, Billadeau DD, Paya CV.
  Title
Protein kinase Calpha (PKCalpha) acts upstream of PKCtheta to activate IkappaB kinase and NF-kappaB in T lymphocytes.
  Journal
Mol Cell Biol 23:7068-81 (2003)
DOI:10.1128/MCB.23.19.7068-7081.2003
Reference
PMID:14517314
  Authors
Hutchins JR, Dikovskaya D, Clarke PR.
  Title
Regulation of Cdc2/cyclin B activation in Xenopus egg extracts via inhibitory phosphorylation of Cdc25C phosphatase by Ca(2+)/calmodulin-dependent protein [corrected] kinase II.
  Journal
Mol Biol Cell 14:4003-14 (2003)
DOI:10.1091/mbc.E03-02-0061
Reference
PMID:21338471
  Authors
Tornquist K
  Title
Sphingosine 1-phosphate, sphingosine kinase and autocrine calcium signalling in thyroid cells.
  Journal
Acta Physiol (Oxf) 204:151-7 (2012)
DOI:10.1111/j.1748-1716.2011.02265.x
Reference
PMID:22129055
  Authors
Feske S
  Title
Immunodeficiency due to defects in store-operated calcium entry.
  Journal
Ann N Y Acad Sci 1238:74-90 (2011)
DOI:10.1111/j.1749-6632.2011.06240.x
Reference
PMID:22002090
  Authors
Giachini FR, Lima VV, Hannan JL, Carneiro FS, Webb RC, Tostes RC
  Title
STIM1/Orai1-mediated store-operated Ca2+ entry: the tip of the iceberg.
  Journal
Braz J Med Biol Res 44:1080-7 (2011)
DOI:10.1590/S0100-879X2011007500133
Reference
PMID:19172794
  Authors
Baba Y, Kurosaki T
  Title
[Regulation of store-operated calcium entry by STIM1].
  Journal
Seikagaku 80:1123-8 (2008)
Reference
PMID:19475418
  Authors
Galione A, Evans AM, Ma J, Parrington J, Arredouani A, Cheng X, Zhu MX
  Title
The acid test: the discovery of two-pore channels (TPCs) as NAADP-gated endolysosomal Ca(2+) release channels.
  Journal
Pflugers Arch 458:869-76 (2009)
DOI:10.1007/s00424-009-0682-y
Reference
PMID:19434403
  Authors
Beard NA, Wei L, Dulhunty AF
  Title
Ca(2+) signaling in striated muscle: the elusive roles of triadin, junctin, and calsequestrin.
  Journal
Eur Biophys J 39:27-36 (2009)
DOI:10.1007/s00249-009-0449-6
Reference
PMID:26228554
  Authors
Marty I
  Title
Triadin regulation of the ryanodine receptor complex.
  Journal
J Physiol 593:3261-6 (2015)
DOI:10.1113/jphysiol.2014.281147
Reference
PMID:20807542
  Authors
Arvanitis DA, Vafiadaki E, Sanoudou D, Kranias EG
  Title
Histidine-rich calcium binding protein: the new regulator of sarcoplasmic reticulum calcium cycling.
  Journal
J Mol Cell Cardiol 50:43-9 (2011)
DOI:10.1016/j.yjmcc.2010.08.021
Related
pathway
pcoo04010  MAPK signaling pathway
pcoo04070  Phosphatidylinositol signaling system
pcoo04210  Apoptosis
pcoo04720  Long-term potentiation
pcoo04730  Long-term depression
KO pathway
ko04020   
LinkDB

DBGET integrated database retrieval system