KEGG   PATHWAY: pleu05208
Entry
pleu05208                   Pathway                                
Name
Chemical carcinogenesis - reactive oxygen species - Peromyscus leucopus (white-footed mouse)
Description
It is well established that cancer is a multi-step process which involves initiation, promotion and progression. Chemical carcinogens can alter any of these processes to induce their carcinogenic effects. In the majority of instances, chemical carcinogens, directly or after xenobiotic metabolism, induce DNA damage and act in a 'genotoxic' manner. There is, however, a group of carcinogens that induce cancer via nongenotoxic mechanisms. The biochemical modes of action for nongenotoxic carcinogens are diverse, one example of which is induction of oxidative stress. Trace metals and organic xenobiotics are typical classes of environmental pollutants with prooxidant effects. Trace metals generate reactive oxygen species (ROS) depending on their ability to lose electrons and catalyze Haber Weiss and Fenton reactions. ROS are also generated due to induction of various cytochrome P450 isoenzymes during detoxification of chemical carcinogens. Increased ROS generation often has been linked to DNA damage that can lead to mutations and may, therefore, play an important role in the initiation and progression of multistage carcinogenesis. Besides causing DNA damage, ROS further induce multiple intracellular signaling pathways, notably NF-kappa B, JNK/SAPK/p38, as well as Erk/MAPK. These signaling routes can lead to transcriptional induction of target genes that could promote proliferation or confer apoptosis resistance to exposed cells.
Class
Human Diseases; Cancer: overview
Pathway map
pleu05208  Chemical carcinogenesis - reactive oxygen species
pleu05208

Organism
Peromyscus leucopus (white-footed mouse) [GN:pleu]
Gene
114680676  Bad; bcl2-associated agonist of cell death isoform X1 [KO:K02158]
114680703  [KO:K02273]
114680796  Pdpk1; 3-phosphoinositide-dependent protein kinase 1 isoform X1 [KO:K06276] [EC:2.7.11.1]
114680800  Ndufb10; NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 10 [KO:K03966]
114681169  Ndufs5; NADH dehydrogenase [ubiquinone] iron-sulfur protein 5 [KO:K03938]
114681332  [KO:K02266]
114681400  Hmox1; heme oxygenase 1 [KO:K00510] [EC:1.14.14.18]
114681434  Prkd2; serine/threonine-protein kinase D2 [KO:K06070] [EC:2.7.11.13]
114681520  Mapk9; mitogen-activated protein kinase 9 isoform X1 [KO:K04440] [EC:2.7.11.24]
114681524  Akt2; RAC-beta serine/threonine-protein kinase isoform X1 [KO:K04456] [EC:2.7.11.1]
114681554  [KO:K07416] [EC:1.14.14.1]
114681621  Sos1; son of sevenless homolog 1 [KO:K03099]
114681638  [KO:K02270]
114681644  [KO:K02267]
114681741  [KO:K00237]
114681835  Src; proto-oncogene tyrosine-protein kinase Src isoform X1 [KO:K05704] [EC:2.7.10.2]
114681906  Ptpn11; LOW QUALITY PROTEIN: tyrosine-protein phosphatase non-receptor type 11 [KO:K07293] [EC:3.1.3.48]
114681917  Vdac1; voltage-dependent anion-selective channel protein 1 [KO:K05862]
114681926  [KO:K00418]
114682022  Atp5f1e; ATP synthase subunit epsilon, mitochondrial [KO:K02135]
114682099  Rela; transcription factor p65 [KO:K04735]
114682408  Arnt; aryl hydrocarbon receptor nuclear translocator isoform X1 [KO:K09097]
114682692  Egf; pro-epidermal growth factor [KO:K04357]
114682732  Mapk1; mitogen-activated protein kinase 1 [KO:K04371] [EC:2.7.11.24]
114682741  Nox4; NADPH oxidase 4 isoform X1 [KO:K21423] [EC:1.6.3.-]
114683045  [KO:K02135]
114683205  Nfkb1; nuclear factor NF-kappa-B p105 subunit [KO:K02580]
114683240  Acp1; low molecular weight phosphotyrosine protein phosphatase [KO:K14394] [EC:3.1.3.2 3.1.3.48]
114683572  [KO:K06070] [EC:2.7.11.13]
114683578  [KO:K07410] [EC:1.14.14.1]
114683746  Hif1a; hypoxia-inducible factor 1-alpha isoform X1 [KO:K08268]
114683985  [KO:K14394] [EC:3.1.3.2 3.1.3.48]
114684032  Pik3cd; LOW QUALITY PROTEIN: phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform [KO:K00922] [EC:2.7.1.153]
114684114  Ndufs7; NADH dehydrogenase [ubiquinone] iron-sulfur protein 7, mitochondrial [KO:K03940] [EC:7.1.1.2]
114684126  Atp5f1d; ATP synthase subunit delta, mitochondrial [KO:K02134]
114684224  Sos2; son of sevenless homolog 2 isoform X1 [KO:K03099]
114684849  Ptprj; LOW QUALITY PROTEIN: receptor-type tyrosine-protein phosphatase eta [KO:K05698] [EC:3.1.3.48]
114685127  [KO:K02833]
114685317  Ndufa7; NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 7 [KO:K03951]
114685415  Sdhc; succinate dehydrogenase cytochrome b560 subunit, mitochondrial [KO:K00236]
114685431  Ndufs2; NADH dehydrogenase [ubiquinone] iron-sulfur protein 2, mitochondrial [KO:K03935] [EC:7.1.1.2]
114685872  [KO:K03967]
114686066  Map2k7; LOW QUALITY PROTEIN: dual specificity mitogen-activated protein kinase kinase 7 [KO:K04431] [EC:2.7.12.2]
114686142  Ephx3; epoxide hydrolase 3 [KO:K22368] [EC:3.3.2.10]
114686406  [KO:K01253] [EC:3.3.2.9]
114686525  [KO:K00420]
114686535  [KO:K00799] [EC:2.5.1.18]
114686683  Ndufa13; NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 13 [KO:K11353]
114686793  [KO:K00799] [EC:2.5.1.18]
114686794  [KO:K00799] [EC:2.5.1.18]
114686795  [KO:K00799] [EC:2.5.1.18]
114686796  [KO:K00799] [EC:2.5.1.18]
114686797  [KO:K00799] [EC:2.5.1.18]
114686798  [KO:K00799] [EC:2.5.1.18]
114686928  Atp5f1b; ATP synthase subunit beta, mitochondrial [KO:K02133] [EC:7.1.2.2]
114687327  Hgf; LOW QUALITY PROTEIN: hepatocyte growth factor [KO:K05460]
114687550  Pld2; phospholipase D2 [KO:K01115] [EC:3.1.4.4]
114687713  [KO:K02267]
114687986  [KO:K00799] [EC:2.5.1.18]
114688121  Map2k2; dual specificity mitogen-activated protein kinase kinase 2 [KO:K04369] [EC:2.7.12.2]
114688175  [KO:K14394] [EC:3.1.3.2 3.1.3.48]
114688226  Ndufb7; NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 7 [KO:K03963]
114688434  Ndufa3; NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 3 [KO:K03947]
114688488  [KO:K02833]
114688857  Ndufa11; NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 11 [KO:K03956]
114688966  Pik3r2; phosphatidylinositol 3-kinase regulatory subunit beta isoform X1 [KO:K02649]
114689098  [KO:K00079] [EC:1.1.1.184 1.1.1.189 1.1.1.197]
114689636  Raf1; RAF proto-oncogene serine/threonine-protein kinase isoform X1 [KO:K04366] [EC:2.7.11.1]
114689804  [KO:K00417]
114689841  [KO:K02271]
114689912  Mgst3; microsomal glutathione S-transferase 3 [KO:K00799] [EC:2.5.1.18]
114690246  Sdhd; succinate dehydrogenase [ubiquinone] cytochrome b small subunit, mitochondrial [KO:K00237]
114690337  [KO:K07408] [EC:1.14.14.1]
114690344  [KO:K02264]
114690345  [KO:K07409] [EC:1.14.14.1]
114690660  Akt3; RAC-gamma serine/threonine-protein kinase isoform X1 [KO:K04456] [EC:2.7.11.1]
114690723  [KO:K02271]
114690777  [KO:K02265]
114690973  [KO:K02264]
114691380  Sod2; superoxide dismutase [Mn], mitochondrial [KO:K04564] [EC:1.15.1.1]
114691497  Map2k1; dual specificity mitogen-activated protein kinase kinase 1 isoform X2 [KO:K04368] [EC:2.7.12.2]
114691777  Mapk10; mitogen-activated protein kinase 10 isoform X1 [KO:K04440] [EC:2.7.11.24]
114691816  Ephx4; epoxide hydrolase 4 [KO:K22369] [EC:3.3.-.-]
114691845  Slc26a1; sulfate anion transporter 1 [KO:K14700]
114691928  [KO:K05862]
114692176  [KO:K00415]
114692200  Ndufab1; acyl carrier protein, mitochondrial [KO:K03955]
114692337  [KO:K00799] [EC:2.5.1.18]
114692338  [KO:K00799] [EC:2.5.1.18]
114692339  [KO:K00799] [EC:2.5.1.18]
114692342  [KO:K00799] [EC:2.5.1.18]
114692343  [KO:K00799] [EC:2.5.1.18]
114692671  Ptpn1; tyrosine-protein phosphatase non-receptor type 1 [KO:K05696] [EC:3.1.3.48]
114692923  Atp5mc1; ATP synthase F(0) complex subunit C1, mitochondrial [KO:K02128]
114693019  Mapk12; mitogen-activated protein kinase 12 [KO:K04441] [EC:2.7.11.24]
114693020  Mapk11; mitogen-activated protein kinase 11 isoform X5 [KO:K04441] [EC:2.7.11.24]
114693118  Map2k4; dual specificity mitogen-activated protein kinase kinase 4 isoform X1 [KO:K04430] [EC:2.7.12.2]
114693378  Nfkbia; NF-kappa-B inhibitor alpha [KO:K04734]
114693387  [KO:K07415] [EC:1.14.14.-]
114693469  [KO:K02273]
114693493  [KO:K02833]
114693559  Pik3cb; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform [KO:K00922] [EC:2.7.1.153]
114693595  Hras; GTPase HRas isoform X1 [KO:K02833]
114693708  Ncf1; neutrophil cytosol factor 1 [KO:K08011]
114693768  Jun; transcription factor AP-1 [KO:K04448]
114693920  [KO:K02266]
114694100  [KO:K00419]
114694169  [KO:K00413]
114694322  Ndufa6; NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 6 [KO:K03950]
114694445  [KO:K05863]
114694672  Ndufs8; NADH dehydrogenase [ubiquinone] iron-sulfur protein 8, mitochondrial [KO:K03941] [EC:7.1.1.2]
114694673  [KO:K02268]
114694721  Met; hepatocyte growth factor receptor isoform X1 [KO:K05099] [EC:2.7.10.1]
114694751  Ndufv1; NADH dehydrogenase [ubiquinone] flavoprotein 1, mitochondrial [KO:K03942] [EC:7.1.1.2]
114694791  [KO:K02271]
114694811  Ndufb9; NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 9 [KO:K03965]
114694895  Atp5f1a; ATP synthase subunit alpha, mitochondrial [KO:K02132]
114695037  Mgst1; microsomal glutathione S-transferase 1 [KO:K00799] [EC:2.5.1.18]
114695216  Keap1; LOW QUALITY PROTEIN: kelch-like ECH-associated protein 1 [KO:K10456]
114695335  Pik3ca; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform [KO:K00922] [EC:2.7.1.153]
114695345  Ndufb5; NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 5, mitochondrial [KO:K03961]
114695599  Ndufa5; NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 5 [KO:K03949]
114695785  [KO:K06070] [EC:2.7.11.13]
114695853  Ndufc1; NADH dehydrogenase [ubiquinone] 1 subunit C1, mitochondrial [KO:K03967]
114695881  Mgst2; microsomal glutathione S-transferase 2 [KO:K00799] [EC:2.5.1.18]
114696086  Sdha; succinate dehydrogenase [ubiquinone] flavoprotein subunit, mitochondrial [KO:K00234] [EC:1.3.5.1]
114696107  Ndufs6; LOW QUALITY PROTEIN: NADH dehydrogenase [ubiquinone] iron-sulfur protein 6, mitochondrial [KO:K03939]
114696316  Ndufv2; NADH dehydrogenase [ubiquinone] flavoprotein 2, mitochondrial [KO:K03943] [EC:7.1.1.2]
114696494  [KO:K00799] [EC:2.5.1.18]
114696495  [KO:K00799] [EC:2.5.1.18]
114696497  [KO:K00799] [EC:2.5.1.18]
114696498  [KO:K00799] [EC:2.5.1.18]
114696553  [KO:K02833]
114696614  Atp5mc2; ATP synthase F(0) complex subunit C2, mitochondrial [KO:K02128]
114696706  [KO:K00799] [EC:2.5.1.18]
114696723  [KO:K00799] [EC:2.5.1.18]
114696744  As3mt; arsenite methyltransferase isoform X1 [KO:K07755] [EC:2.1.1.137]
114697006  Nox1; NADPH oxidase 1 [KO:K08008]
114697038  [KO:K00417]
114697539  Pld1; phospholipase D1 [KO:K01115] [EC:3.1.4.4]
114697686  Atp5pf; ATP synthase-coupling factor 6, mitochondrial [KO:K02131]
114698038  Fos; proto-oncogene c-Fos [KO:K04379]
114698062  Slc26a9; solute carrier family 26 member 9 isoform X2 [KO:K14706]
114698423  Atp5po; ATP synthase subunit O, mitochondrial [KO:K02137]
114698452  Sod1; LOW QUALITY PROTEIN: superoxide dismutase [Cu-Zn] [KO:K04565] [EC:1.15.1.1]
114698582  Nras; GTPase NRas [KO:K07828]
114698667  Ndufc2; NADH dehydrogenase [ubiquinone] 1 subunit C2 [KO:K03968]
114699005  Cat; catalase [KO:K03781] [EC:1.11.1.6]
114699258  [KO:K12550] [EC:1.11.1.7]
114699348  Mapk8; mitogen-activated protein kinase 8 isoform X1 [KO:K04440] [EC:2.7.11.24]
114699378  [KO:K14394] [EC:3.1.3.2 3.1.3.48]
114699390  Ahr; aryl hydrocarbon receptor [KO:K09093]
114699672  Ndufs3; NADH dehydrogenase [ubiquinone] iron-sulfur protein 3, mitochondrial [KO:K03936] [EC:7.1.1.2]
114699830  [KO:K03937]
114699990  [KO:K00799] [EC:2.5.1.18]
114699991  [KO:K00799] [EC:2.5.1.18]
114699992  [KO:K00799] [EC:2.5.1.18]
114699993  [KO:K00799] [EC:2.5.1.18]
114699994  [KO:K00799] [EC:2.5.1.18]
114699995  [KO:K00799] [EC:2.5.1.18]
114699996  [KO:K00799] [EC:2.5.1.18]
114699997  [KO:K00799] [EC:2.5.1.18]
114699999  Gstm3; glutathione S-transferase Mu 3 [KO:K00799] [EC:2.5.1.18]
114700220  Vdac2; voltage-dependent anion-selective channel protein 2 [KO:K15040]
114700271  [KO:K02270]
114700346  [KO:K00079] [EC:1.1.1.184 1.1.1.189 1.1.1.197]
114700572  Ndufa12; NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 12 [KO:K11352]
114700676  Ndufa10; LOW QUALITY PROTEIN: NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 10, mitochondrial [KO:K03954]
114700818  Nfe2l2; nuclear factor erythroid 2-related factor 2 isoform X1 [KO:K05638]
114700826  Atp5mc3; ATP synthase F(0) complex subunit C3, mitochondrial [KO:K02128]
114700886  Sdhb; succinate dehydrogenase [ubiquinone] iron-sulfur subunit, mitochondrial [KO:K00235] [EC:1.3.5.1]
114700949  [KO:K02263]
114700968  [KO:K08009]
114701092  [KO:K00411] [EC:7.1.1.8]
114701179  Slc25a4; ADP/ATP translocase 1 [KO:K05863]
114701446  Ndufa9; NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 9, mitochondrial [KO:K03953]
114701507  [KO:K02128]
114701855  [KO:K00411] [EC:7.1.1.8]
114701979  [KO:K00417]
114702264  Map3k14; mitogen-activated protein kinase kinase kinase 14 isoform X2 [KO:K04466] [EC:2.7.11.25]
114702631  [KO:K03945]
114703046  Akt1; RAC-alpha serine/threonine-protein kinase [KO:K04456] [EC:2.7.11.1]
114703266  Ndufb6; NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 6 [KO:K03962]
114703635  [KO:K02268]
114703694  [KO:K03944]
114703705  Ndufs4; NADH dehydrogenase [ubiquinone] iron-sulfur protein 4, mitochondrial isoform X1 [KO:K03937]
114703784  Abl1; tyrosine-protein kinase ABL1 isoform X1 [KO:K06619] [EC:2.7.10.2]
114703831  Ndufb11; NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 11, mitochondrial [KO:K11351]
114703850  Pik3r1; phosphatidylinositol 3-kinase regulatory subunit alpha isoform X1 [KO:K02649]
114703900  Araf; serine/threonine-protein kinase A-Raf isoform X2 [KO:K08845] [EC:2.7.11.1]
114703999  Ndufv3; NADH dehydrogenase [ubiquinone] flavoprotein 3, mitochondrial [KO:K03944]
114704190  [KO:K02268]
114704332  Mapk3; mitogen-activated protein kinase 3 [KO:K04371] [EC:2.7.11.24]
114704407  [KO:K02266]
114704425  [KO:K03957]
114704466  Prkd1; serine/threonine-protein kinase D1 isoform X1 [KO:K06070] [EC:2.7.11.13]
114704485  Ndufb3; NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 3 [KO:K03959]
114704659  Ptk2; focal adhesion kinase 1 isoform X1 [KO:K05725] [EC:2.7.10.2]
114704715  Ndufa8; NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 8 [KO:K03952]
114704795  Ndufa4l2; NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 4-like 2 [KO:K03948]
114704883  [KO:K02271]
114705083  Ndufa2; NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 2 [KO:K03946]
114705194  [KO:K00414]
114705197  Slc26a6; solute carrier family 26 member 6 isoform X1 [KO:K14704]
114705300  Vegfa; vascular endothelial growth factor A isoform X1 [KO:K05448]
114705416  Slc25a5; ADP/ATP translocase 2 [KO:K05863]
114705437  Ndufa1; NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 1 [KO:K03945]
114705532  Egfr; epidermal growth factor receptor isoform X1 [KO:K04361] [EC:2.7.10.1]
114705570  [KO:K02263]
114705738  Ikbkb; inhibitor of nuclear factor kappa-B kinase subunit beta isoform X1 [KO:K07209] [EC:2.7.11.10]
114705743  Vdac3; voltage-dependent anion-selective channel protein 3 isoform X1 [KO:K15041]
114705971  [KO:K00417]
114706041  Ndufb1; NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 1 [KO:K03957]
114706046  [KO:K02273]
114706162  Mapk13; mitogen-activated protein kinase 13 [KO:K04441] [EC:2.7.11.24]
114706165  Mapk14; mitogen-activated protein kinase 14 isoform X1 [KO:K04441] [EC:2.7.11.24]
114706175  Ikbkg; NF-kappa-B essential modulator isoform X1 [KO:K07210]
114706431  Chuk; inhibitor of nuclear factor kappa-B kinase subunit alpha isoform X1 [KO:K04467] [EC:2.7.11.10]
114706734  Nqo1; NAD(P)H dehydrogenase [quinone] 1 [KO:K00355] [EC:1.6.5.2]
114706830  Braf; LOW QUALITY PROTEIN: serine/threonine-protein kinase B-raf [KO:K04365] [EC:2.7.11.1]
114706832  Ndufb2; NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 2, mitochondrial [KO:K03958]
114706860  [KO:K00416]
114706924  Pik3r3; phosphatidylinositol 3-kinase regulatory subunit gamma isoform X1 [KO:K02649]
114707024  Grb2; growth factor receptor-bound protein 2 [KO:K04364]
114707050  Atp5pd; ATP synthase subunit d, mitochondrial [KO:K02138]
114707058  Akr1a1; aldo-keto reductase family 1 member A1 isoform X1 [KO:K00002] [EC:1.1.1.2]
114707249  Atp5pb; ATP synthase F(0) complex subunit B1, mitochondrial [KO:K02127]
114707310  Ephx2; bifunctional epoxide hydrolase 2 [KO:K08726] [EC:3.3.2.10 3.1.3.76]
114707391  Slc26a2; LOW QUALITY PROTEIN: sulfate transporter [KO:K14701]
114707517  Foxo3; LOW QUALITY PROTEIN: forkhead box protein O3 [KO:K09408]
114707535  Rac1; ras-related C3 botulinum toxin substrate 1 isoform X1 [KO:K04392]
114707771  [KO:K02127]
114707814  [KO:K00212] [EC:1.1.1.149 1.1.1.357 1.3.1.20]
114708002  [KO:K00212] [EC:1.1.1.149 1.1.1.357 1.3.1.20]
114708030  [KO:K00212] [EC:1.1.1.149 1.1.1.357 1.3.1.20]
114708096  [KO:K04119] [EC:1.1.1.51 1.1.1.188 1.1.1.213 1.1.1.357]
114708122  Ndufb8; NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 8, mitochondrial [KO:K03964]
114708186  Prkcd; protein kinase C delta type isoform X1 [KO:K06068] [EC:2.7.11.13]
114708203  Ndufs1; NADH-ubiquinone oxidoreductase 75 kDa subunit, mitochondrial [KO:K03934] [EC:7.1.1.2]
114708306  Atp5f1c; ATP synthase subunit gamma, mitochondrial isoform X1 [KO:K02136]
114708408  [KO:K02272]
114708477  Kras; GTPase KRas isoform X2 [KO:K07827]
114708599  [KO:K03941] [EC:7.1.1.2]
114708619  [KO:K02268]
114708910  [KO:K02270]
114709626  Ppif; peptidyl-prolyl cis-trans isomerase F, mitochondrial isoform X1 [KO:K09565] [EC:5.2.1.8]
114709796  [KO:K00417]
114710174  [KO:K00417]
114710215  [KO:K02138]
114710475  Ndufa4; cytochrome c oxidase subunit NDUFA4 [KO:K03948]
114710523  [KO:K04371] [EC:2.7.11.24]
114710722  Ndufb4; NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 4 [KO:K03960]
114710781  Slc25a31; ADP/ATP translocase 4 [KO:K05863]
114711016  [KO:K05863]
119088668  [KO:K02272]
119088843  [KO:K00079] [EC:1.1.1.184 1.1.1.189 1.1.1.197]
36275531  ATP6; ATP synthase F0 subunit 6 [KO:K02126]
36275532  COX3; cytochrome c oxidase subunit III [KO:K02262]
36275535  ND4; NADH dehydrogenase subunit 4 [KO:K03881] [EC:7.1.1.2]
36275537  ND6; NADH dehydrogenase subunit 6 [KO:K03884] [EC:7.1.1.2]
36275544  ND1; NADH dehydrogenase subunit 1 [KO:K03878] [EC:7.1.1.2]
36275547  ND2; NADH dehydrogenase subunit 2 [KO:K03879] [EC:7.1.1.2]
36275552  COX1; cytochrome c oxidase subunit I [KO:K02256] [EC:7.1.1.9]
36275554  COX2; cytochrome c oxidase subunit II [KO:K02261]
36275555  ATP8; ATP synthase F0 subunit 8 [KO:K02125]
36275556  ND3; NADH dehydrogenase subunit 3 [KO:K03880] [EC:7.1.1.2]
36275557  ND4L; NADH dehydrogenase subunit 4L [KO:K03882] [EC:7.1.1.2]
36275560  ND5; NADH dehydrogenase subunit 5 [KO:K03883] [EC:7.1.1.2]
36275561  CYTB; cytochrome b [KO:K00412]
Compound
C00001  H2O
C00003  NAD+
C00005  NADPH
C00006  NADP+
C00007  Oxygen
C00019  S-Adenosyl-L-methionine
C00021  S-Adenosyl-L-homocysteine
C00023  Iron
C00027  Hydrogen peroxide
C00051  Glutathione
C00070  Copper
C00084  Acetaldehyde
C00127  Glutathione disulfide
C00146  Phenol
C00291  Nickel
C00469  Ethanol
C00472  p-Benzoquinone
C00530  Hydroquinone
C00704  Superoxide
C00951  Estradiol-17beta
C01407  Benzene
C01413  Cadmium
C01782  Benzene oxide
C02389  p-Benzosemiquinone
C02575  Pentachlorophenol
C02814  Benzene-1,2,4-triol
C03434  Tetrachlorohydroquinone
C03622  N-Hydroxy-4-aminobiphenyl
C04623  DDT
C05301  2-Hydroxyestradiol
C05309  Semiquinone
C05981  Phosphatidylinositol-3,4,5-trisphosphate
C06268  Chromium
C06269  Arsenic
C06696  Lead
C07294  Methylarsonate
C07295  Methanearsonous acid
C07308  Cacodylate
C07535  Benzo[a]pyrene
C07557  2,3,7,8-Tetrachlorodibenzodioxin
C10998  4-Aminobiphenyl
C14209  4-Hydroxy-17beta-estradiol
C14850  Benzo[a]pyrene-7,8-oxide
C14852  Benzo[a]pyrene-7,8-dihydrodiol
C16038  2-Amino-1-methyl-6-phenylimidazo[4,5-b]pyridine
C16453  4-(N-Nitrosomethylamino)-1-(3-pyridyl)-1-butanone
C16844  Hydroxyl radical
C18205  2,2',4,4'-Tetrabromodiphenyl ether
C18933  Chloranil
C19171  Cobalt
C20300  Dimethylarsinous acid
C20316  4-Nitrosobiphenyl
C20319  Hydronitroxide radical
C22355  Benzo[a]pyrene-7,8-diol
C22356  Benzo[a]pyrene-7,8-dione
C22357  17beta-Estradiol-2,3-quinone
C22381  Reactive oxygen species
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Related
pathway
pleu00190  Oxidative phosphorylation
pleu00980  Metabolism of xenobiotics by cytochrome P450
pleu04010  MAPK signaling pathway
pleu04064  NF-kappa B signaling pathway
pleu04066  HIF-1 signaling pathway
pleu04151  PI3K-Akt signaling pathway
pleu04370  VEGF signaling pathway
pleu05207  Chemical carcinogenesis - receptor activation
pleu05211  Renal cell carcinoma
pleu05215  Prostate cancer
pleu05219  Bladder cancer
pleu05221  Acute myeloid leukemia
pleu05222  Small cell lung cancer
pleu05223  Non-small cell lung cancer
pleu05224  Breast cancer
pleu05225  Hepatocellular carcinoma
KO pathway
ko05208   

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