KEGG   PATHWAY: pswi04060
Entry
pswi04060                   Pathway                                
Name
Cytokine-cytokine receptor interaction - Pseudoliparis swirei (Mariana hadal snailfish)
Description
Cytokines are soluble extracellular proteins or glycoproteins that are crucial intercellular regulators and mobilizers of cells engaged in innate as well as adaptive inflammatory host defenses, cell growth, differentiation, cell death, angiogenesis, and development and repair processes aimed at the restoration of homeostasis. Cytokines are released by various cells in the body, usually in response to an activating stimulus, and they induce responses through binding to specific receptors on the cell surface of target cells. Cytokines can be grouped by structure into different families and their receptors can likewise be grouped.
Class
Environmental Information Processing; Signaling molecules and interaction
Pathway map
pswi04060  Cytokine-cytokine receptor interaction
pswi04060

Organism
Pseudoliparis swirei (Mariana hadal snailfish) [GN:pswi]
Gene
130187969  tnfb; tumor necrosis factor b (TNF superfamily, member 2) [KO:K05468]
130187998  [KO:K05073]
130188424  ifnphi1; interferon phi 1 [KO:K05414]
130188425  csf2rb; cytokine receptor common subunit beta isoform X1 [KO:K04738]
130188524  epor; erythropoietin receptor [KO:K05079]
130188579  ngfra; tumor necrosis factor receptor superfamily member 16 [KO:K02583]
130188721  [KO:K05070]
130189255  il2rb; interleukin-2 receptor subunit beta [KO:K05069]
130189258  il12rb2l; interleukin 12 receptor, beta 2a, like isoform X1 [KO:K05060]
130189484  [KO:K05477]
130189545  [KO:K05132]
130189747  [KO:K05433]
130190112  [KO:K05069]
130190140  cxcl8a; interleukin-8 isoform X1 [KO:K10030]
130190389  [KO:K05143]
130190475  prl; prolactin [KO:K05439]
130190528  ccr7; C-C chemokine receptor type 7 [KO:K04182]
130190669  cxcl12b; chemokine (C-X-C motif) ligand 12b (stromal cell-derived factor 1) [KO:K10031]
130190937  crfb16; cytokine receptor family member B16 isoform X1 [KO:K05137]
130191197  [KO:K05131]
130191203  il10rb; LOW QUALITY PROTEIN: interleukin-10 receptor subunit beta [KO:K05135]
130191217  [KO:K05135]
130191322  [KO:K05171]
130191323  [KO:K04386]
130191533  admp; anti-dorsalizing morphogenic protein [KO:K21283]
130191593  lifra; LIF receptor subunit alpha a [KO:K05058]
130191715  il12bb; interleukin-12 subunit beta [KO:K05425]
130191752  [KO:K05090] [EC:2.7.10.1]
130191946  il13ra2; interleukin-13 receptor subunit alpha-2 [KO:K05077]
130192382  bmp8a; bone morphogenetic protein 8A isoform X1 [KO:K16622]
130192574  [KO:K05071]
130192781  [KO:K05173]
130192841  [KO:K05491]
130193166  [KO:K05174]
130193225  [KO:K05173]
130193290  il16; pro-interleukin-16 isoform X1 [KO:K22628]
130193858  mpl; thrombopoietin receptor isoform X1 [KO:K05082]
130193992  ccl44; chemokine (C-C motif) ligand 44 [KO:K21083]
130194055  [KO:K04193]
130194112  il12rb1; uncharacterized protein il12rb1 [KO:K05063]
130194288  lepr; leptin receptor [KO:K05062]
130194422  amh; muellerian-inhibiting factor isoform X1 [KO:K04665]
130194444  il23r; interleukin-23 receptor isoform X1 [KO:K05064]
130194449  il12rb2; interleukin-12 receptor subunit beta-2 isoform X1 [KO:K05064]
130194492  faslg; tumor necrosis factor ligand superfamily member 6 [KO:K04389]
130194905  [KO:K04388] [EC:2.7.11.30]
130194956  prl2; LOW QUALITY PROTEIN: prolactin 2 [KO:K05439]
130194957  [KO:K05164]
130195364  il17c; interleukin-17C [KO:K05491]
130195521  il34; interleukin-34 [KO:K22633]
130195946  gdf6b; growth/differentiation factor 6-B [KO:K20012]
130196253  ghra; growth hormone receptor a isoform X1 [KO:K05080]
130196354  [KO:K04722]
130196486  spaw; southpaw [KO:K04666]
130196829  il12b2; interleukin-12 subunit beta isoform X1 [KO:K05425]
130196898  bmp10; bone morphogenetic protein 10 [KO:K22670]
130196967  bmp3; bone morphogenetic protein 3 [KO:K05496]
130197056  ccl27a; C-C motif chemokine 27a [KO:K05513]
130197339  [KO:K04519]
130197544  acvr2ba; activin receptor type-2B [KO:K13596] [EC:2.7.11.30]
130197677  [KO:K05504]
130198029  [KO:K04189]
130198054  [KO:K05405]
130198075  zmp:0000001127; interleukin-12 subunit alpha [KO:K05406]
130198524  [KO:K14625]
130198533  [KO:K04193]
130198994  [KO:K05168]
130198995  wu:fl23c11; uncharacterized protein wu:fl23c11 isoform X1 [KO:K05166]
130199339  tnfrsf9a; tumor necrosis factor receptor superfamily member 9a [KO:K05144]
130199375  ngfa; neurotrophin-7 [KO:K02582]
130199592  [KO:K05165]
130199653  cd40; tumor necrosis factor receptor superfamily member 5 [KO:K03160]
130199677  [KO:K03158]
130199682  acvr1ba; activin A receptor type 1Ba [KO:K13567] [EC:2.7.11.30]
130199792  acvrl1; serine/threonine-protein kinase receptor R3 [KO:K13594] [EC:2.7.11.30]
130199851  bmp7b; bone morphogenetic protein 7b [KO:K16621]
130199993  [KO:K04675] [EC:2.7.11.30]
130200288  [KO:K05074]
130200385  il22; interleukin-22 [KO:K05445]
130200910  il17ra1a; interleukin 17 receptor A1a [KO:K05164]
130201274  tgfb3; transforming growth factor beta-3 proprotein [KO:K13377]
130201490  ebi3; interleukin-27 subunit beta [KO:K24476]
130201692  [KO:K04721]
130201724  [KO:K04675] [EC:2.7.11.30]
130201768  ccr6b; C-C chemokine receptor type 6 [KO:K04181]
130201842  tnfsf13b; LOW QUALITY PROTEIN: tumor necrosis factor ligand superfamily member 13B [KO:K05476]
130201919  bmp4; bone morphogenetic protein 4 [KO:K04662]
130202378  [KO:K05050]
130202520  gdf3; protein DVR-1 [KO:K22672]
130202603  bmp2b; bone morphogenetic protein 2b [KO:K21283]
130202833  il20ra; interleukin-20 receptor subunit alpha [KO:K05136]
130202874  [KO:K13377]
130202964  [KO:K22630]
130203049  tnfrsf21; tumor necrosis factor receptor superfamily member 21 [KO:K05157]
130203054  il17a/f3; interleukin 17a/f3 [KO:K05494]
130203163  mstnb; growth/differentiation factor 8 [KO:K05497]
130203360  gdf2; growth/differentiation factor 2 [KO:K05503]
130203363  gdf10b; growth/differentiation factor 10b [KO:K22674]
130203534  ngfrb; nerve growth factor receptor b [KO:K02583]
130203731  [KO:K05414]
130203732  [KO:K05414]
130203734  [KO:K05414]
130203736  [KO:K05414]
130203744  [KO:K05414]
130203877  ackr3a; atypical chemokine receptor 3a [KO:K04304]
130203909  [KO:K05075]
130204030  ndr2; nodal-related 2 [KO:K04666]
130204138  [KO:K21283]
130204272  inha; inhibin alpha chain [KO:K05500]
130204326  [KO:K05497]
130204365  [KO:K04671] [EC:2.7.11.30]
130204385  [KO:K04670] [EC:2.7.11.30]
130204393  [KO:K22687]
130204493  [KO:K13568] [EC:2.7.11.30]
130204602  [KO:K05080]
130204735  cxcr4b; C-X-C chemokine receptor type 4b [KO:K04189]
130204807  [KO:K05050]
130205047  edar; tumor necrosis factor receptor superfamily member EDAR [KO:K05162]
130205120  ghrb; growth hormone receptor b isoform X1 [KO:K05080]
130205176  bmpr1bb; bone morphogenetic protein receptor, type IBb isoform X1 [KO:K13578] [EC:2.7.11.30]
130205306  tnfrsfa; tumor necrosis factor receptor superfamily, member a [KO:K04722]
130205339  [KO:K04671] [EC:2.7.11.30]
130205360  il6st; interleukin-6 receptor subunit beta [KO:K05060]
130205470  [KO:K22670]
130205551  cntfr; ciliary neurotrophic factor receptor subunit alpha isoform X1 [KO:K05059]
130205597  [KO:K04666]
130205607  il11ra; interleukin-11 receptor subunit alpha isoform X1 [KO:K05056]
130205720  [KO:K05072]
130205974  bmp6; bone morphogenetic protein 6 [KO:K16620]
130206014  tgfbr1b; TGF-beta receptor type-1b [KO:K04674] [EC:2.7.11.30]
130206043  tgfbr2b; TGF-beta receptor type-2 [KO:K04388] [EC:2.7.11.30]
130206268  [KO:K04184]
130206280  inhbaa; inhibin subunit beta Aa [KO:K04667]
130206318  ccl20b; C-C motif chemokine 20b [KO:K14625]
130206378  tnfrsf11a; tumor necrosis factor receptor superfamily member 11A [KO:K05147]
130206475  tgfb2; transforming growth factor beta-2 proprotein isoform X1 [KO:K13376]
130206536  [KO:K04721]
130206724  ackr4b; atypical chemokine receptor 4b [KO:K04186]
130206829  [KO:K04673] [EC:2.7.11.30]
130206978  acvr2aa; activin receptor type-2A isoform X1 [KO:K04670] [EC:2.7.11.30]
130207035  inhbb; inhibin beta B chain [KO:K22687]
130207194  [KO:K05416]
130207235  gdf10a; growth/differentiation factor 10 [KO:K22674]
130207324  ifngr1l; interferon gamma receptor 1-like [KO:K05132]
130207355  il17d; interleukin-17D [KO:K05492]
130207372  bmp5; bone morphogenetic protein 5 [KO:K04663]
130207464  fas; tumor necrosis factor receptor superfamily member 23 [KO:K04390]
130207621  cxcl12a; chemokine (C-X-C motif) ligand 12a (stromal cell-derived factor 1) [KO:K10031]
130207865  [KO:K04387]
130208244  gdf5; growth/differentiation factor 5 [KO:K04664]
130208341  tnfrsf1b; tumor necrosis factor receptor superfamily member 1B [KO:K05141]
130208373  [KO:K16621]
130208544  il10; interleukin-10 [KO:K05443]
130208593  il17rc; interleukin-17 receptor C [KO:K05166]
130208760  ngfb; nerve growth factor [KO:K02582]
130208799  [KO:K22687]
130208833  gdf11; growth/differentiation factor 11 isoform X1 [KO:K22679]
130208868  [KO:K13567] [EC:2.7.11.30]
130209052  il19l; interleukin 19 like [KO:K22667]
130209266  [KO:K05480]
130209282  csf1ra; macrophage colony-stimulating factor 1 receptor [KO:K05090] [EC:2.7.10.1]
130209410  gdf9; growth/differentiation factor 9 [KO:K22673]
130209442  rell2; RELT-like protein 2 isoform X1 [KO:K26541]
130209644  tgfb5; transforming growth factor beta-2 proprotein [KO:K13376]
130209695  clcf1; uncharacterized protein clcf1 isoform X1 [KO:K05421]
130209719  [KO:K22629]
130209868  cd40lg; CD40 ligand [KO:K04389]
130210186  cxcl14; C-X-C motif chemokine 14 [KO:K10033]
130210467  il12a; interleukin-12 subunit alpha isoform X1 [KO:K05406]
130210613  bmp16; bone morphogenetic protein 16 [KO:K21283]
130210696  [KO:K04723]
130210864  smtla; somatolactin alpha [KO:K05438]
130210959  tgfb1a; transforming growth factor, beta 1a [KO:K13375]
130211075  relt; tumor necrosis factor receptor superfamily member 19L [KO:K05156]
130211079  thpo; thrombopoietin [KO:K06854]
130211321  il10ra; LOW QUALITY PROTEIN: interleukin-10 receptor subunit alpha [KO:K05134]
130211361  [KO:K05155]
130211693  tnfsf12; tumor necrosis factor ligand superfamily member 12 [KO:K05474]
130211890  bmp15; bone morphogenetic protein 15 [KO:K05498]
130211959  [KO:K05077]
130212073  epoa; erythropoietin [KO:K05437]
130212090  rell1; RELT-like protein 1 [KO:K26541]
130212558  ifnlr1; interferon lambda receptor 1 isoform X1 [KO:K05136]
130212661  cxcr3.2; C-X-C chemokine receptor type 3-2 [KO:K04188]
130212662  cxcr3.1; C-X-C chemokine receptor type 3.1 [KO:K04188]
130212664  [KO:K04188]
130212752  il6r; interleukin-6 receptor subunit alpha isoform X1 [KO:K05055]
130212884  nradd; tumor necrosis factor receptor superfamily member 16 [KO:K02583]
130212952  gdf6a; growth/differentiation factor 6-A [KO:K20012]
130213043  cabz01093075.1; C-C chemokine receptor type 5 [KO:K04179]
130213148  [KO:K22628]
130213289  [KO:K04180]
130213351  si:cabz01093077.1; LOW QUALITY PROTEIN: C-C chemokine receptor type 2 [KO:K04179]
130213357  [KO:K05148]
130213358  [KO:K05143]
130213407  csf3r; granulocyte colony-stimulating factor receptor isoform X1 [KO:K05061]
130213463  tnfrsf1a; tumor necrosis factor receptor superfamily member 1A [KO:K03158]
130213471  [KO:K03160]
130213487  il11a; uncharacterized protein il11a [KO:K05417]
Reference
PMID:24892271
  Authors
Turner MD, Nedjai B, Hurst T, Pennington DJ
  Title
Cytokines and chemokines: At the crossroads of cell signalling and inflammatory disease.
  Journal
Biochim Biophys Acta 1843:2563-2582 (2014)
DOI:10.1016/j.bbamcr.2014.05.014
Reference
PMID:21106488
  Authors
Brocker C, Thompson D, Matsumoto A, Nebert DW, Vasiliou V
  Title
Evolutionary divergence and functions of the human interleukin (IL) gene family.
  Journal
Hum Genomics 5:30-55 (2010)
DOI:10.1186/1479-7364-5-1-30
Reference
PMID:27577879
  Authors
Akdis M, Aab A, Altunbulakli C, Azkur K, Costa RA, Crameri R, Duan S, Eiwegger T, Eljaszewicz A, Ferstl R, Frei R, Garbani M, Globinska A, Hess L, Huitema C, Kubo T, Komlosi Z, Konieczna P, Kovacs N, Kucuksezer UC, Meyer N, Morita H, Olzhausen J, O'Mahony L, Pezer M, Prati M, Rebane A, Rhyner C, Rinaldi A, Sokolowska M, Stanic B, Sugita K, Treis A, van de Veen W, Wanke K, Wawrzyniak M, Wawrzyniak P, Wirz OF, Zakzuk JS, Akdis CA
  Title
Interleukins (from IL-1 to IL-38), interferons, transforming growth factor beta, and TNF-alpha: Receptors, functions, and roles in diseases.
  Journal
J Allergy Clin Immunol 138:984-1010 (2016)
DOI:10.1016/j.jaci.2016.06.033
Reference
PMID:15500860
  Authors
Boulanger MJ, Garcia KC
  Title
Shared cytokine signaling receptors: structural insights from the gp130 system.
  Journal
Adv Protein Chem 68:107-46 (2004)
DOI:10.1016/S0065-3233(04)68004-1
Reference
PMID:16034365
  Authors
Allan SM, Tyrrell PJ, Rothwell NJ
  Title
Interleukin-1 and neuronal injury.
  Journal
Nat Rev Immunol 5:629-40 (2005)
DOI:10.1038/nri1664
Reference
PMID:23847622
  Authors
Lopetuso LR, Chowdhry S, Pizarro TT
  Title
Opposing Functions of Classic and Novel IL-1 Family Members in Gut Health and Disease.
  Journal
Front Immunol 4:181 (2013)
DOI:10.3389/fimmu.2013.00181
Reference
PMID:21349428
  Authors
Iwakura Y, Ishigame H, Saijo S, Nakae S
  Title
Functional specialization of interleukin-17 family members.
  Journal
Immunity 34:149-62 (2011)
DOI:10.1016/j.immuni.2011.02.012
Reference
PMID:17530315
  Authors
Fischer P, Hilfiker-Kleiner D
  Title
Survival pathways in hypertrophy and heart failure: the gp130-STAT3 axis.
  Journal
Basic Res Cardiol 102:279-97 (2007)
DOI:10.1007/s00395-007-0658-z
Reference
PMID:24381786
  Authors
Richards CD
  Title
The enigmatic cytokine oncostatin m and roles in disease.
  Journal
ISRN Inflamm 2013:512103 (2013)
DOI:10.1155/2013/512103
Reference
PMID:18926762
  Authors
Zhang Q, Putheti P, Zhou Q, Liu Q, Gao W
  Title
Structures and biological functions of IL-31 and IL-31 receptors.
  Journal
Cytokine Growth Factor Rev 19:347-56 (2008)
DOI:10.1016/j.cytogfr.2008.08.003
Reference
PMID:21155715
  Authors
Meenhuis A, Verwijmeren C, Roovers O, Touw IP
  Title
The deubiquitinating enzyme DUB2A enhances CSF3 signalling by attenuating lysosomal routing of the CSF3 receptor.
  Journal
Biochem J 434:343-51 (2011)
DOI:10.1042/BJ20101628
Reference
PMID:22410872
  Authors
de Weerd NA, Nguyen T
  Title
The interferons and their receptors--distribution and regulation.
  Journal
Immunol Cell Biol 90:483-91 (2012)
DOI:10.1038/icb.2012.9
Reference
PMID:12949498
  Authors
Aggarwal BB
  Title
Signalling pathways of the TNF superfamily: a double-edged sword.
  Journal
Nat Rev Immunol 3:745-56 (2003)
DOI:10.1038/nri1184
Reference
PMID:12189384
  Authors
Ashkenazi A
  Title
Targeting death and decoy receptors of the tumour-necrosis factor superfamily.
  Journal
Nat Rev Cancer 2:420-30 (2002)
DOI:10.1038/nrc821
Reference
PMID:26115564
  Authors
Seeger P, Musso T, Sozzani S
  Title
The TGF-beta superfamily in dendritic cell biology.
  Journal
Cytokine Growth Factor Rev 26:647-57 (2015)
DOI:10.1016/j.cytogfr.2015.06.002
Reference
PMID:23612460
  Authors
Wakefield LM, Hill CS
  Title
Beyond TGFbeta: roles of other TGFbeta superfamily members in cancer.
  Journal
Nat Rev Cancer 13:328-41 (2013)
DOI:10.1038/nrc3500
Reference
PMID:22710174
  Authors
Mueller TD, Nickel J
  Title
Promiscuity and specificity in BMP receptor activation.
  Journal
FEBS Lett 586:1846-59 (2012)
DOI:10.1016/j.febslet.2012.02.043
KO pathway
ko04060   

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