KEGG   PATHWAY: shr05224
Entry
shr05224                    Pathway                                
Name
Breast cancer - Sarcophilus harrisii (Tasmanian devil)
Description
Breast cancer is the leading cause of cancer death among women worldwide. The vast majority of breast cancers are carcinomas that originate from cells lining the milk-forming ducts of the mammary gland. The molecular subtypes of breast cancer, which are based on the presence or absence of hormone receptors (estrogen and progesterone subtypes) and human epidermal growth factor receptor-2 (HER2), include: hormone receptor positive and HER2 negative (luminal A subtype), hormone receptor positive and HER2 positive (luminal B subtype), hormone receptor negative and HER2 positive (HER2 positive), and hormone receptor negative and HER2 negative (basal-like or triple-negative breast cancers (TNBCs)). Hormone receptor positive breast cancers are largely driven by the estrogen/ER pathway. In HER2 positive breast tumours, HER2 activates the PI3K/AKT and the RAS/RAF/MAPK pathways, and stimulate cell growth, survival and differentiation. In patients suffering from TNBC, the deregulation of various signalling pathways (Notch and Wnt/beta-catenin), EGFR protein have been confirmed. In the case of breast cancer only 8% of all cancers are hereditary, a phenomenon linked to genetic changes in BRCA1 or BRCA2. Somatic mutations in only three genes (TP53, PIK3CA and GATA3) occurred at >10% incidence across all breast cancers.
Class
Human Diseases; Cancer: specific types
Pathway map
shr05224  Breast cancer
shr05224

Organism
Sarcophilus harrisii (Tasmanian devil) [GN:shr]
Gene
100935401  ESR1; estrogen receptor isoform X1 [KO:K08550]
100915121  ESR2; estrogen receptor beta [KO:K08551]
100924872  NCOA1; nuclear receptor coactivator 1 isoform X1 [KO:K09101] [EC:2.3.1.48]
100923646  NCOA3; nuclear receptor coactivator 3 isoform X2 [KO:K11256] [EC:2.3.1.48]
100924435  FOS; proto-oncogene c-Fos [KO:K04379]
116423739  JUN; transcription factor AP-1 [KO:K04448]
100930024  SP1; transcription factor Sp1 isoform X1 [KO:K04684]
100917462  CCND1; G1/S-specific cyclin-D1 [KO:K04503]
100921308  MYC; myc proto-oncogene protein [KO:K04377]
100932349  PGR; progesterone receptor isoform X1 [KO:K08556]
100928059  WNT1; proto-oncogene Wnt-1 [KO:K03209]
100925510  WNT4; protein Wnt-4 isoform X1 [KO:K00408]
105750026  TNFSF11; tumor necrosis factor ligand superfamily member 11 [KO:K05473]
100914727  ERBB2; receptor tyrosine-protein kinase erbB-2 isoform X1 [KO:K05083] [EC:2.7.10.1]
100929695  FGF1; fibroblast growth factor 1 isoform X1 [KO:K18496]
100934542  FGF2; fibroblast growth factor 2 [KO:K18497]
100923118  FGF18; fibroblast growth factor 18 [KO:K04358]
100925286  FGF20; fibroblast growth factor 20 [KO:K04358]
100928224  FGF5; fibroblast growth factor 5 [KO:K04358]
100934722  FGF6; fibroblast growth factor 6 [KO:K04358]
100921812  FGF4; fibroblast growth factor 4 [KO:K04358]
100922075  FGF3; fibroblast growth factor 3 [KO:K04358]
100925381  FGF8; fibroblast growth factor 8 isoform X3 [KO:K04358]
100925383  FGF7; fibroblast growth factor 7 [KO:K04358]
100932059  FGF17; fibroblast growth factor 17 [KO:K04358]
100934743  FGF16; fibroblast growth factor 16 [KO:K04358]
100915656  FGF22; fibroblast growth factor 22 [KO:K04358]
100920456  FGF9; fibroblast growth factor 9 [KO:K04358]
116423189  FGF10; fibroblast growth factor 10 [KO:K04358]
100916676  FGF19; fibroblast growth factor 19 [KO:K22603]
100931317  FGF21; fibroblast growth factor 21 [KO:K22429]
100914586  FGF23; fibroblast growth factor 23 [KO:K22428]
100914347  FGFR1; fibroblast growth factor receptor 1 isoform X1 [KO:K04362] [EC:2.7.10.1]
100918816  IGF1; insulin-like growth factor I isoform X1 [KO:K05459]
100916673  IGF1R; insulin-like growth factor 1 receptor [KO:K05087] [EC:2.7.10.1]
100933169  EGF; pro-epidermal growth factor isoform X1 [KO:K04357]
100914017  EGFR; epidermal growth factor receptor isoform X1 [KO:K04361] [EC:2.7.10.1]
100929346  KIT; mast/stem cell growth factor receptor Kit isoform X2 [KO:K05091] [EC:2.7.10.1]
100926921  SHC1; SHC-transforming protein 1 isoform X4 [KO:K06279]
100917745  SHC2; SHC-transforming protein 2 isoform X1 [KO:K17447]
100914800  SHC3; SHC-transforming protein 3 isoform X1 [KO:K17448]
100927458  SHC4; SHC-transforming protein 4 isoform X1 [KO:K17449]
100928380  GRB2; growth factor receptor-bound protein 2 [KO:K04364]
100931009  SOS1; son of sevenless homolog 1 isoform X2 [KO:K03099]
100932999  SOS2; son of sevenless homolog 2 isoform X1 [KO:K03099]
100929168  ras-like protein [KO:K02833]
116419913  HRAS; GTPase HRas [KO:K02833]
100915526  KRAS; GTPase KRas isoform X1 [KO:K07827]
100927252  ras-related protein Rab-26-like [KO:K07827]
100929426  ras protein let-60-like [KO:K07827]
100928986  NRAS; GTPase NRas [KO:K07828]
100913901  ARAF; serine/threonine-protein kinase A-Raf [KO:K08845] [EC:2.7.11.1]
100934801  BRAF; serine/threonine-protein kinase B-raf isoform X1 [KO:K04365] [EC:2.7.11.1]
100935202  RAF1; RAF proto-oncogene serine/threonine-protein kinase isoform X2 [KO:K04366] [EC:2.7.11.1]
100921899  MAP2K1; dual specificity mitogen-activated protein kinase kinase 1 isoform X1 [KO:K04368] [EC:2.7.12.2]
100917396  MAP2K2; dual specificity mitogen-activated protein kinase kinase 2 isoform X1 [KO:K04369] [EC:2.7.12.2]
100934330  MAPK3; mitogen-activated protein kinase 3 [KO:K04371] [EC:2.7.11.24]
100913231  MAPK1; mitogen-activated protein kinase 1 isoform X1 [KO:K04371] [EC:2.7.11.24]
100929811  PIK3CB; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform [KO:K00922] [EC:2.7.1.153]
100932099  PIK3CA; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform [KO:K00922] [EC:2.7.1.153]
105749979  PIK3CD; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform [KO:K00922] [EC:2.7.1.153]
100926892  PIK3R2; phosphatidylinositol 3-kinase regulatory subunit beta [KO:K02649]
100924976  PIK3R1; phosphatidylinositol 3-kinase regulatory subunit alpha isoform X2 [KO:K02649]
100935230  PIK3R3; phosphatidylinositol 3-kinase regulatory subunit gamma isoform X1 [KO:K02649]
100927199  PTEN; phosphatidylinositol 3,4,5-trisphosphate 3-phosphatase and dual-specificity protein phosphatase PTEN [KO:K01110] [EC:3.1.3.16 3.1.3.48 3.1.3.67]
100917987  AKT1; RAC-alpha serine/threonine-protein kinase [KO:K04456] [EC:2.7.11.1]
100913262  AKT3; RAC-gamma serine/threonine-protein kinase [KO:K04456] [EC:2.7.11.1]
100925440  AKT2; RAC-beta serine/threonine-protein kinase [KO:K04456] [EC:2.7.11.1]
100931480  MTOR; serine/threonine-protein kinase mTOR isoform X1 [KO:K07203] [EC:2.7.11.1]
100935081  RPS6KB2; ribosomal protein S6 kinase beta-2 isoform X1 [KO:K04688] [EC:2.7.11.1]
100930707  RPS6KB1; ribosomal protein S6 kinase beta-1 isoform X2 [KO:K04688] [EC:2.7.11.1]
100931367  JAG1; protein jagged-1 [KO:K06052]
100921475  JAG2; protein jagged-2 isoform X1 [KO:K21635]
100919868  DLL1; delta-like protein 1 [KO:K06051]
100933691  DLL4; delta-like protein 4 isoform X1 [KO:K06051]
100928250  NOTCH1; neurogenic locus notch homolog protein 1 [KO:K02599]
100919958  NOTCH2; neurogenic locus notch homolog protein 2 [KO:K20994]
100926977  NOTCH3; neurogenic locus notch homolog protein 3 [KO:K20995]
111720114  HES1; transcription factor HES-1 [KO:K06054]
116422873  HES4; transcription factor HES-4 [KO:K06054]
100933566  transcription factor HES-5 [KO:K06055]
100933821  transcription factor HES-5-like [KO:K06055]
100916286  HEYL; hairy/enhancer-of-split related with YRPW motif-like protein [KO:K09091]
100922275  HEY1; hairy/enhancer-of-split related with YRPW motif protein 1 [KO:K09091]
100918295  HEY2; hairy/enhancer-of-split related with YRPW motif protein 2 [KO:K09091]
100932306  FLT4; vascular endothelial growth factor receptor 3 [KO:K05097] [EC:2.7.10.1]
100926666  CDKN1A; cyclin-dependent kinase inhibitor 1 [KO:K06625]
100923463  NFKB2; nuclear factor NF-kappa-B p100 subunit [KO:K04469]
100918306  WNT2; protein Wnt-2 isoform X3 [KO:K00182]
100918389  WNT2B; protein Wnt-2b [KO:K00182]
100914628  WNT3A; protein Wnt-3a [KO:K00312]
100935307  WNT3; proto-oncogene Wnt-3 [KO:K00312]
100917926  WNT5A; protein Wnt-5a [KO:K00444]
100924415  WNT5B; protein Wnt-5b [KO:K00444]
100933826  WNT6; protein Wnt-6 [KO:K00445]
100925362  WNT7B; protein Wnt-7b [KO:K00572]
100931119  WNT7A; protein Wnt-7a [KO:K00572]
100934290  WNT8B; protein Wnt-8b [KO:K00714]
100923381  WNT8A; protein Wnt-8a [KO:K00714]
100914365  WNT9A; protein Wnt-9a [KO:K01064]
100919162  WNT9B; LOW QUALITY PROTEIN: protein Wnt-9b [KO:K01064]
100917765  WNT10A; protein Wnt-10a [KO:K01357]
100932979  WNT10B; protein Wnt-10b isoform X2 [KO:K01357]
100913767  WNT11; protein Wnt-11 [KO:K01384]
100921973  WNT16; protein Wnt-16 [KO:K01558]
100921540  FZD1; frizzled-1 [KO:K02432]
100923425  FZD7; frizzled-7 [KO:K02432]
100932536  FZD2; frizzled-2 [KO:K02235]
100919821  FZD3; frizzled-3 isoform X1 [KO:K02329]
100919498  FZD4; frizzled-4 [KO:K02354]
100916636  FZD5; frizzled-5 [KO:K02375]
111721152  FZD8; frizzled-8 [KO:K02375]
100919476  FZD6; frizzled-6 isoform X1 [KO:K02376]
100914963  FZD10; frizzled-10 [KO:K02842]
100930633  LRP6; low-density lipoprotein receptor-related protein 6 [KO:K03068]
100916936  LRP5; low-density lipoprotein receptor-related protein 5 [KO:K03068]
100932600  DVL1; segment polarity protein dishevelled homolog DVL-1 [KO:K02353]
100932119  DVL3; segment polarity protein dishevelled homolog DVL-3 [KO:K02353]
100931932  DVL2; segment polarity protein dishevelled homolog DVL-2 [KO:K02353]
105749059  proto-oncogene FRAT1 [KO:K03069]
100930993  GSK-3-binding protein FRAT2 [KO:K03096]
100920192  GSK3B; glycogen synthase kinase-3 beta isoform X1 [KO:K03083] [EC:2.7.11.26]
100923576  AXIN1; axin-1 isoform X1 [KO:K02157]
100933740  AXIN2; axin-2 isoform X1 [KO:K04385]
100925931  APC2; adenomatous polyposis coli protein 2 isoform X1 [KO:K02085]
100915224  APC; adenomatous polyposis coli protein isoform X1 [KO:K02085]
100930636  CTNNB1; catenin beta-1 isoform X1 [KO:K02105]
100915381  CSNK1A1; casein kinase I isoform X1 [KO:K08957] [EC:2.7.11.1]
100924173  casein kinase I-like [KO:K08957] [EC:2.7.11.1]
100919354  casein kinase I-like [KO:K08957] [EC:2.7.11.1]
105751130  LOW QUALITY PROTEIN: casein kinase I [KO:K08957] [EC:2.7.11.1]
100930141  TCF7; transcription factor 7 isoform X1 [KO:K02620]
100922609  TCF7L1; transcription factor 7-like 1 [KO:K04490]
100922675  TCF7L2; transcription factor 7-like 2 isoform X11 [KO:K04491]
100934638  LEF1; lymphoid enhancer-binding factor 1 isoform X1 [KO:K04492]
100922473  TP53; cellular tumor antigen p53 isoform X1 [KO:K04451]
100926902  GADD45G; growth arrest and DNA damage-inducible protein GADD45 gamma [KO:K04402]
100920439  GADD45B; growth arrest and DNA damage-inducible protein GADD45 beta [KO:K04402]
116423727  GADD45A; growth arrest and DNA damage-inducible protein GADD45 alpha [KO:K04402]
100916731  BAK1; bcl-2 homologous antagonist/killer isoform X2 [KO:K14021]
100916232  DDB2; DNA damage-binding protein 2 [KO:K10140]
100923657  POLK; DNA polymerase kappa isoform X1 [KO:K03511] [EC:2.7.7.7]
100932899  CDK4; cyclin-dependent kinase 4 [KO:K02089] [EC:2.7.11.22]
100924154  CDK6; cyclin-dependent kinase 6 [KO:K02091] [EC:2.7.11.22]
100914196  RB1; retinoblastoma-associated protein [KO:K06618]
116421696  E2F1; transcription factor E2F1 isoform X1 [KO:K17454]
100921594  E2F2; transcription factor E2F2 [KO:K09389]
100934669  E2F3; transcription factor E2F3 isoform X1 [KO:K06620]
100914310  BRCA1; breast cancer type 1 susceptibility protein isoform X1 [KO:K10605] [EC:2.3.2.27]
100915673  BRCA2; breast cancer type 2 susceptibility protein [KO:K08775]
Compound
C00410  Progesterone
C00951  Estradiol-17beta
C05981  Phosphatidylinositol-3,4,5-trisphosphate
Reference
PMID:24649067
  Authors
Zhang MH, Man HT, Zhao XD, Dong N, Ma SL
  Title
Estrogen receptor-positive breast cancer molecular signatures and therapeutic potentials (Review).
  Journal
Biomed Rep 2:41-52 (2014)
DOI:10.3892/br.2013.187
Reference
PMID:27390604
  Authors
Dai X, Xiang L, Li T, Bai Z
  Title
Cancer Hallmarks, Biomarkers and Breast Cancer Molecular Subtypes.
  Journal
J Cancer 7:1281-94 (2016)
DOI:10.7150/jca.13141
Reference
PMID:20436504
  Authors
Schnitt SJ
  Title
Classification and prognosis of invasive breast cancer: from morphology to molecular taxonomy.
  Journal
Mod Pathol 23 Suppl 2:S60-4 (2010)
DOI:10.1038/modpathol.2010.33
Reference
PMID:23000897
  Authors
  Title
Comprehensive molecular portraits of human breast tumours.
  Journal
Nature 490:61-70 (2012)
DOI:10.1038/nature11412
Reference
PMID:22178455
  Authors
Eroles P, Bosch A, Perez-Fidalgo JA, Lluch A
  Title
Molecular biology in breast cancer: intrinsic subtypes and signaling pathways.
  Journal
Cancer Treat Rev 38:698-707 (2012)
DOI:10.1016/j.ctrv.2011.11.005
Reference
  Authors
Karamouzis MV, Papavassiliou KA, Adamopoulos C, Papavassiliou AG.
  Title
Targeting androgen/estrogen receptors crosstalk in cancer
  Journal
Trends Cancer 2:35-48 (2016)
DOI:10.1016/j.trecan.2015.12.001
Reference
  Authors
Sharp A, Harper-Wynne C.
  Title
Treatment of advanced breast cancer (ABC): the expanding landscape of targeted therapies
  Journal
J Cancer Biol Res 2:1036 (2014)
Reference
PMID:24596345
  Authors
Byler S, Goldgar S, Heerboth S, Leary M, Housman G, Moulton K, Sarkar S
  Title
Genetic and epigenetic aspects of breast cancer progression and therapy.
  Journal
Anticancer Res 34:1071-7 (2014)
Reference
PMID:23988612
  Authors
Mohamed A, Krajewski K, Cakar B, Ma CX
  Title
Targeted therapy for breast cancer.
  Journal
Am J Pathol 183:1096-112 (2013)
DOI:10.1016/j.ajpath.2013.07.005
Reference
PMID:22722193
  Authors
Ellis MJ, Ding L, Shen D, Luo J, Suman VJ, Wallis JW, Van Tine BA, Hoog J, Goiffon RJ, Goldstein TC, Ng S, Lin L, Crowder R, Snider J, Ballman K, Weber J, Chen K, Koboldt DC, Kandoth C, Schierding WS, McMichael JF, Miller CA, Lu C, Harris CC, McLellan MD, Wendl MC, DeSchryver K, Allred DC, Esserman L, Unzeitig G, Margenthaler J, Babiera GV, Marcom PK, Guenther JM, Leitch M, Hunt K, Olson J, Tao Y, Maher CA, Fulton LL, Fulton RS, Harrison M, Oberkfell B, Du F, Demeter R, Vickery TL, Elhammali A, Piwnica-Worms H, McDonald S, Watson M, Dooling DJ, Ota D, Chang LW, Bose R, Ley TJ, Piwnica-Worms D, Stuart JM, Wilson RK, Mardis ER
  Title
Whole-genome analysis informs breast cancer response to aromatase inhibition.
  Journal
Nature 486:353-60 (2012)
DOI:10.1038/nature11143
Reference
PMID:25907219
  Authors
Ma CX, Reinert T, Chmielewska I, Ellis MJ
  Title
Mechanisms of aromatase inhibitor resistance.
  Journal
Nat Rev Cancer 15:261-75 (2015)
DOI:10.1038/nrc3920
Reference
PMID:16113099
  Authors
Butt AJ, McNeil CM, Musgrove EA, Sutherland RL
  Title
Downstream targets of growth factor and oestrogen signalling and endocrine resistance: the potential roles of c-Myc, cyclin D1 and cyclin E.
  Journal
Endocr Relat Cancer 12 Suppl 1:S47-59 (2005)
DOI:10.1677/erc.1.00993
Reference
PMID:24111892
  Authors
Dasgupta S, Lonard DM, O'Malley BW
  Title
Nuclear receptor coactivators: master regulators of human health and disease.
  Journal
Annu Rev Med 65:279-92 (2014)
DOI:10.1146/annurev-med-051812-145316
Reference
PMID:23702927
  Authors
Brisken C
  Title
Progesterone signalling in breast cancer: a neglected hormone coming into the limelight.
  Journal
Nat Rev Cancer 13:385-96 (2013)
DOI:10.1038/nrc3518
Reference
PMID:20087430
  Authors
Scarpin KM, Graham JD, Mote PA, Clarke CL
  Title
Progesterone action in human tissues: regulation by progesterone receptor (PR) isoform expression, nuclear positioning and coregulator expression.
  Journal
Nucl Recept Signal 7:e009 (2009)
DOI:10.1621/nrs.07009
Reference
PMID:24291072
  Authors
Knutson TP, Lange CA
  Title
Tracking progesterone receptor-mediated actions in breast cancer.
  Journal
Pharmacol Ther 142:114-25 (2014)
DOI:10.1016/j.pharmthera.2013.11.010
Reference
PMID:25544707
  Authors
Dittrich A, Gautrey H, Browell D, Tyson-Capper A
  Title
The HER2 Signaling Network in Breast Cancer--Like a Spider in its Web.
  Journal
J Mammary Gland Biol Neoplasia 19:253-70 (2014)
DOI:10.1007/s10911-014-9329-5
Reference
PMID:21965336
  Authors
Higgins MJ, Baselga J
  Title
Targeted therapies for breast cancer.
  Journal
J Clin Invest 121:3797-803 (2011)
DOI:10.1172/JCI57152
Reference
PMID:26028978
  Authors
Mukohara T
  Title
PI3K mutations in breast cancer: prognostic and therapeutic implications.
  Journal
Breast Cancer (Dove Med Press) 7:111-23 (2015)
DOI:10.2147/BCTT.S60696
Reference
PMID:19088017
  Authors
Schneider BP, Winer EP, Foulkes WD, Garber J, Perou CM, Richardson A, Sledge GW, Carey LA
  Title
Triple-negative breast cancer: risk factors to potential targets.
  Journal
Clin Cancer Res 14:8010-8 (2008)
DOI:10.1158/1078-0432.CCR-08-1208
Reference
PMID:21898546
  Authors
King TD, Suto MJ, Li Y
  Title
The Wnt/beta-catenin signaling pathway: a potential therapeutic target in the treatment of triple negative breast cancer.
  Journal
J Cell Biochem 113:13-8 (2012)
DOI:10.1002/jcb.23350
Reference
PMID:11737884
  Authors
Brown AM
  Title
Wnt signaling in breast cancer: have we come full circle?
  Journal
Breast Cancer Res 3:351-5 (2001)
DOI:10.1186/bcr321
Reference
PMID:21076461
  Authors
Geyer FC, Lacroix-Triki M, Savage K, Arnedos M, Lambros MB, MacKay A, Natrajan R, Reis-Filho JS
  Title
beta-Catenin pathway activation in breast cancer is associated with triple-negative phenotype but not with CTNNB1 mutation.
  Journal
Mod Pathol 24:209-31 (2011)
DOI:10.1038/modpathol.2010.205
Reference
PMID:20971825
  Authors
Al-Hussaini H, Subramanyam D, Reedijk M, Sridhar SS
  Title
Notch signaling pathway as a therapeutic target in breast cancer.
  Journal
Mol Cancer Ther 10:9-15 (2011)
DOI:10.1158/1535-7163.MCT-10-0677
Reference
PMID:26968398
  Authors
Rangel MC, Bertolette D, Castro NP, Klauzinska M, Cuttitta F, Salomon DS
  Title
Developmental signaling pathways regulating mammary stem cells and contributing to the etiology of triple-negative breast cancer.
  Journal
Breast Cancer Res Treat 156:211-26 (2016)
DOI:10.1007/s10549-016-3746-7
Reference
PMID:26040571
  Authors
Jamdade VS, Sethi N, Mundhe NA, Kumar P, Lahkar M, Sinha N
  Title
Therapeutic targets of triple-negative breast cancer: a review.
  Journal
Br J Pharmacol 172:4228-37 (2015)
DOI:10.1111/bph.13211
Reference
PMID:23196196
  Authors
Karamboulas C, Ailles L
  Title
Developmental signaling pathways in cancer stem cells of solid tumors.
  Journal
Biochim Biophys Acta 1830:2481-95 (2013)
DOI:10.1016/j.bbagen.2012.11.008
Reference
PMID:23881035
  Authors
Ignatiadis M, Sotiriou C
  Title
Luminal breast cancer: from biology to treatment.
  Journal
Nat Rev Clin Oncol 10:494-506 (2013)
DOI:10.1038/nrclinonc.2013.124
Reference
PMID:25013431
  Authors
Shin SJ, Gong G, Lee HJ, Kang J, Bae YK, Lee A, Cho EY, Lee JS, Suh KS, Lee DW, Jung WH
  Title
Positive expression of insulin-like growth factor-1 receptor is associated with a positive hormone receptor status and a favorable prognosis in breast cancer.
  Journal
J Breast Cancer 17:113-20 (2014)
DOI:10.4048/jbc.2014.17.2.113
Reference
PMID:11879567
  Authors
Gasco M, Shami S, Crook T
  Title
The p53 pathway in breast cancer.
  Journal
Breast Cancer Res 4:70-6 (2002)
DOI:10.1186/bcr426
Reference
PMID:15343273
  Authors
Narod SA, Foulkes WD
  Title
BRCA1 and BRCA2: 1994 and beyond.
  Journal
Nat Rev Cancer 4:665-76 (2004)
DOI:10.1038/nrc1431
Related
pathway
shr03440  Homologous recombination
shr04010  MAPK signaling pathway
shr04110  Cell cycle
shr04115  p53 signaling pathway
shr04151  PI3K-Akt signaling pathway
shr04310  Wnt signaling pathway
shr04330  Notch signaling pathway
shr04915  Estrogen signaling pathway
KO pathway
ko05224   
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