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ENTRY	nt06162
Name	Hepatitis B virus (HBV)
Category	Disease view; Viral infection
Pathway	hsa05161 Hepatitis B
Genome	T40004
Disease	H00412 Hepatitis B H00048 Hepatocellular carcinoma
Display	drug-target relation   disease type

MAPK signaling N00001    EGF → EGFR → GRB2 → SOS → RAS → RAF → MEK → ERK → CCND1 N00540    X → SRC → GRB2 → SOS → RAS → RAF → MEK → ERK → ELK1 N00216    HGF → MET → GRB2 → SOS → RAS → RAF → MEK → ERK N00541                X → RAS N00545                            X → ERK → AP1 ⇒ MMP9 N00542    EGF → EGFR → GRB2 → SOS → RAS → MEKK1 → MKK4 → JNK N00543                            X → JNK → JUN N00538            Ca2+ → PTK2B → SRC → GRB2 → SOS → RAS → RAF → MEK → ERK N00539    X → VDAC3 → Ca2+   PI3K signaling N00033    EGF → EGFR → PI3K → PIP3 → AKT ⊣ BAD N00267        X → PI3K   TGFB signaling N00063        TGFB → (TGFBR2+TGFBR1) → (SMAD2,SMAD3) = SMAD4 N00531    X → TGFB → (TGFBR2+TGFBR1) → (SMAD2,SMAD3) = SMAD4   JAK-STAT signaling N00053    Cytokine → Receptor → JAK → STAT ⇒ PIM1 N00548            X → STAT3   TLR signaling N00435        (TLR1,TLR2,TLR4) → (TIRAP+MYD88) → (IRAK4+IRAK1) → (TRAF6+TAK1+TAB2) → IKK → NFKBIA → NFKB ⇒ (TNF,IL6,IL12A,IL1.. N00556    C ⊣ TLR2 N00557        C ⊣ TIRAP N00549        C ⊣ MYD88 N00550                            C ⊣ NFKB N00438        (TLR2,TLR4) → (TIRAP+MYD88) → (IRAK4+IRAK1) → (TRAF6+TAK1+TAB2) → (MEK,MKK3/6,MKK4/7.. → (ERK,p38,JNK) → AP1 N00551                    S ⊣ JNK N00553        TLR4 → TICAM2 → TICAM1 → TRAF3 → (IKBKE+TBK1) → (IRF3,IRF7) ⇒ IFNB1 N00554        C ⊣ TICAM2 N00555            C ⊣ TICAM1 N00149            TLR3 → TICAM1 → TRAF3 → (IKBKE+TBK1) → IRF3 → (CREBBP,EP300) ⇒ IFNB1 N00552                P ⊣ DDX3X = (IKBKE+TBK1)   RLR signaling N00469        RNA → RIGI → MAVS → TRAF3 → (TANK+NAP1+SINTBAD.. → (TBK1+IKBKE) → (IRF7,IRF3) ⇒ (IFNA,IFNB1) N00268            X ⊣ MAVS   IFN signaling N00150    (IFNA,IFNB1) → (IFNAR1+IFNAR2) → (JAK1,TYK2) → (STAT1+STAT2+IRF9) ⇒ (IRF7,EIF2AK2) N00558            P ⊣ (STAT1+STAT2)   Chemokine signaling N00546    CXCL12 → CXCR4 → GNAQ → (PLCB,PLCG) → IP3 → Ca2+ → PKC → RAF → MEK → ERK N00547                        S → PKC   Cell cycle N00536    CDKN2A ⊣ MDM2 ⊣ TP53 ⇒ CDKN1A ⊣ (CCNE+CDK2) → RB1 ⌿ E2F N00537                X → (CCNE+CDK2) → RB1 ⌿ E2F   Apoptosis N00146    (FASLG,TNFSF10) → (FAS,TNFRSF10B) → FADD → (CASP8,CASP10) → BID → (BAX,BAK1) → CYCS = APAF1 → CASP9 → (CASP3,CASP7) N00534                    X → BAX N00533                            X → BIRC5 ⊣ CASP9   Transcription N00532    X → (EGR2,EGR3) = EP300 ⇒ FASLG N00535    X ⊣ TP53 ⇒ (CDKN1A,BAX,FAS) N00544    X → CREBBP = (CREB+ATF2) ⇒ (CXCL8,PCNA)