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ENTRY	nt06210
Name	ERK signaling (cancer)
Category	Disease view; Cancer signaling
Display	drug-target relation   disease type

N00001    EGF → EGFR → GRB2 → SOS → RAS → RAF → MEK → ERK → CCND1 N00276    EGF* → EGFR → GRB2 → SOS → RAS → RAF → MEK → ERK N00229    TGFA → EGFR → GRB2 → SOS → RAS → RAF → MEK → ERK N00230    TGFA* → EGFR → GRB2 → SOS → RAS → RAF → MEK → ERK N00277    EREG → EGFR → GRB2 → SOS → RAS → RAF → MEK → ERK N00278    EREG* → EGFR → GRB2 → SOS → RAS → RAF → MEK → ERK N00279    AREG → EGFR → GRB2 → SOS → RAS → RAF → MEK → ERK N00280    AREG* → EGFR → GRB2 → SOS → RAS → RAF → MEK → ERK N01354    BPA → EGFR → GRB2 → SOS → RAS → RAF → MEK → ERK N10005        (Gefitinib,Erlotinib,Afatinib,Dacomitinib) ⊥ N10006        Osimertinib ⊥ N00014        EGFR* → GRB2 → SOS → RAS → RAF → MEK → ERK → CCND1 N00513        EGFR* → GRB2 → SOS → RAS → RAF → MEK → ERK → CCND1 N00006        EGFR* → GRB2 → SOS → RAS → RAF → MEK → ERK N00041        EGFR* → GRB2 → SOS → RAS → RAF → MEK → ERK N00021    EGF → (ERBB2+EGFR) → GRB2 → SOS → RAS → RAF → MEK → ERK N10009        (Trastuzumab,Trastuzumab_emtansine,Pertuzumab,Lapatinib,Neratinib,Tucatinib,Margetuximab) ⊥ N00022    EGF → (ERBB2*+EGFR) → GRB2 → SOS → RAS → RAF → MEK → ERK N10009        (Trastuzumab,Trastuzumab_emtansine,Pertuzumab,Lapatinib,Neratinib,Tucatinib,Margetuximab) ⊥ N00252    EGF → (ERBB2*+EGFR) → GRB2 → SOS → RAS → RAF → MEK → ERK N00015    PDGF → PDGFR → GRB2 → SOS → RAS → RAF → MEK → ERK N00016    PDGF* → PDGFR → GRB2 → SOS → RAS → RAF → MEK → ERK N00018        PDGFR* → GRB2 → SOS → RAS → RAF → MEK → ERK N00215    KITLG → KIT → GRB2 → SOS → RAS → RAF → MEK → ERK N00003        KIT* → GRB2 → SOS → RAS → RAF → MEK → ERK N00019    FGF → FGFR → GRB2 → SOS → RAS → RAF → MEK → ERK N00020        FGFR* → GRB2 → SOS → RAS → RAF → MEK → ERK N00011        FGFR3* → GRB2 → SOS → RAS → RAF → MEK → ERK → MSK1 → MYC N00217    FLT3LG → FLT3 → GRB2 → SOS → RAS → RAF → MEK → ERK N00004        FLT3* → GRB2 → SOS → RAS → RAF → MEK → ERK N00233    IGF → IGF1R → GRB2 → SOS → RAS → RAF → MEK → ERK N00235    IGF2* → IGF1R → GRB2 → SOS → RAS → RAF → MEK → ERK N00237    IGF2 → IGF1R* → GRB2 → SOS → RAS → RAF → MEK → ERK N00216    HGF → MET → GRB2 → SOS → RAS → RAF → MEK → ERK N00246    HGF* → MET → GRB2 → SOS → RAS → RAF → MEK → ERK N00005        MET* → GRB2 → SOS → RAS → RAF → MEK → ERK → CCND1 N00259        MET* → GRB2 → SOS → RAS → RAF → MEK → ERK N00248        MET* → GRB2 → SOS → RAS → RAF → MEK → ERK N10024        (Capmatinib,Tepotinib) ⊥ N01062        MET* → GRB2 → SOS → RAS → RAF → MEK → ERK N10001        Imatinib ⊥ N10002        (Dasatinib,Nilotinib,Bostinib,Ponatinib,Asciminib) ⊥ N00002        BCR-ABL → GRB2 → SOS → RAS → RAF → MEK → ERK N00274        NS5A ⊣ GRB2 N01408            Metals → ROS → RAS → RAF → MEK → ERK → AP1 N00009                TRK* → RAS → RAF → MEK → ERK N01064                RET* → RAS → RAF → MEK → ERK N10025                Selpercatinib,Pralsetinib ⊥ N00008                RET* → RAS → RAF → MEK → ERK N10003                Crizotinib ⊥ N10004                (Alectinib,Ceritinib,Brigatinib,Lorlatinib) ⊥ N00007                EML4-ALK → RAS → RAF → MEK → ERK → CCND1 N00160                K1 → RAS N00077                    HRAS* → RAF → MEK → ERK → MSK1 → MYC N00078                    HRAS* → RAF → MEK → ERK → MSK1 → MYC N00012                    (KRAS*,NRAS*) → RAF → MEK → ERK → CCND1 N10007                        (Vemurafenib,Dabrafenib,Encorafenib) ⊥ N10008                            (Trametinib,Cobimetinib,Binimetinib) ⊥ N00013                        BRAF* → MEK → ERK   N01360    P4 → (PGR+SRC) → GRB2 → SOS → RAS → RAF → MEK → ERK → CCND1 N01361    (P4,MPA) → (PGR+SRC) → GRB2 → SOS → RAS → RAF → MEK → ERK → CCND1 N01351        E2 → ESR1/2 → SRC → RAS → RAF → MEK → ERK → CREB N01353        E2 → ESR1/2 → SRC → RAS → RAF → MEK → ERK → (ESR1/2,AP1) ⇒ CHRNA9 N01352        BPA → ESR1/2 → SRC → RAS → RAF → MEK → ERK   N01343        ACh → CHRNA7 → Ca2+ → RAS → RAF → MEK → ERK → CREB N01344        (NNK,NNN) → CHRN → Ca2+ → RAS → RAF → MEK → ERK → (FOS,JUN,MYC,BCL2)