KEGG   ORTHOLOGY: K04344
Entry
K04344                      KO                                     

Name
CACNA1A, CAV2.1
Definition
voltage-dependent calcium channel P/Q type alpha-1A
Pathway
map04010  MAPK signaling pathway
map04020  Calcium signaling pathway
map04721  Synaptic vesicle cycle
map04723  Retrograde endocannabinoid signaling
map04724  Glutamatergic synapse
map04725  Cholinergic synapse
map04726  Serotonergic synapse
map04727  GABAergic synapse
map04728  Dopaminergic synapse
map04730  Long-term depression
map04742  Taste transduction
map04930  Type II diabetes mellitus
map05017  Spinocerebellar ataxia
map05032  Morphine addiction
map05033  Nicotine addiction
map05207  Chemical carcinogenesis - receptor activation
Disease
H00063  Spinocerebellar ataxia (SCA)
H00606  Early infantile epileptic encephalopathy
H00749  Episodic ataxias
H00775  Hemiplegic migraine
H01808  Hemiconvulsion-hemiplegia-epilepsy syndrome
Brite
KEGG Orthology (KO) [BR:ko00001]
 09130 Environmental Information Processing
  09132 Signal transduction
   04010 MAPK signaling pathway
    K04344  CACNA1A, CAV2.1; voltage-dependent calcium channel P/Q type alpha-1A
   04020 Calcium signaling pathway
    K04344  CACNA1A, CAV2.1; voltage-dependent calcium channel P/Q type alpha-1A
 09150 Organismal Systems
  09156 Nervous system
   04724 Glutamatergic synapse
    K04344  CACNA1A, CAV2.1; voltage-dependent calcium channel P/Q type alpha-1A
   04727 GABAergic synapse
    K04344  CACNA1A, CAV2.1; voltage-dependent calcium channel P/Q type alpha-1A
   04725 Cholinergic synapse
    K04344  CACNA1A, CAV2.1; voltage-dependent calcium channel P/Q type alpha-1A
   04728 Dopaminergic synapse
    K04344  CACNA1A, CAV2.1; voltage-dependent calcium channel P/Q type alpha-1A
   04726 Serotonergic synapse
    K04344  CACNA1A, CAV2.1; voltage-dependent calcium channel P/Q type alpha-1A
   04730 Long-term depression
    K04344  CACNA1A, CAV2.1; voltage-dependent calcium channel P/Q type alpha-1A
   04723 Retrograde endocannabinoid signaling
    K04344  CACNA1A, CAV2.1; voltage-dependent calcium channel P/Q type alpha-1A
   04721 Synaptic vesicle cycle
    K04344  CACNA1A, CAV2.1; voltage-dependent calcium channel P/Q type alpha-1A
  09157 Sensory system
   04742 Taste transduction
    K04344  CACNA1A, CAV2.1; voltage-dependent calcium channel P/Q type alpha-1A
 09160 Human Diseases
  09161 Cancer: overview
   05207 Chemical carcinogenesis - receptor activation
    K04344  CACNA1A, CAV2.1; voltage-dependent calcium channel P/Q type alpha-1A
  09164 Neurodegenerative disease
   05017 Spinocerebellar ataxia
    K04344  CACNA1A, CAV2.1; voltage-dependent calcium channel P/Q type alpha-1A
  09165 Substance dependence
   05032 Morphine addiction
    K04344  CACNA1A, CAV2.1; voltage-dependent calcium channel P/Q type alpha-1A
   05033 Nicotine addiction
    K04344  CACNA1A, CAV2.1; voltage-dependent calcium channel P/Q type alpha-1A
  09167 Endocrine and metabolic disease
   04930 Type II diabetes mellitus
    K04344  CACNA1A, CAV2.1; voltage-dependent calcium channel P/Q type alpha-1A
 09180 Brite Hierarchies
  09183 Protein families: signaling and cellular processes
   04040 Ion channels
    K04344  CACNA1A, CAV2.1; voltage-dependent calcium channel P/Q type alpha-1A
Ion channels [BR:ko04040]
 Voltage-gated cation channels
  Calcium channel, voltage-gated (Cav)
   K04344  CACNA1A, CAV2.1; voltage-dependent calcium channel P/Q type alpha-1A
Other DBs
GO: 0005245
TC: 1.A.1.11.8 1.A.1.11.27
Genes
HSA: 773(CACNA1A)
PTR: 455766(CACNA1A)
PPS: 100971898(CACNA1A)
GGO: 101127257(CACNA1A)
PON: 100458387(CACNA1A)
NLE: 100602682(CACNA1A)
MCC: 718291(CACNA1A)
MCF: 102130052(CACNA1A)
CSAB: 103234371(CACNA1A)
CATY: 105601562(CACNA1A)
PANU: 101013922(CACNA1A)
RRO: 104661142(CACNA1A)
RBB: 108544091(CACNA1A)
TFN: 117075607(CACNA1A)
PTEH: 111523866(CACNA1A)
CJC: 100390599(CACNA1A)
SBQ: 101046396(CACNA1A)
MMUR: 105885431(CACNA1A)
MMU: 12286(Cacna1a)
MCAL: 110299941(Cacna1a)
MPAH: 110337404(Cacna1a)
RNO: 25398(Cacna1a)
MCOC: 116067850
MUN: 110545836(Cacna1a)
CGE: 100758171(Cacna1a)
PLEU: 114684157(Cacna1a)
NGI: 103751913(Cacna1a)
HGL: 101725815(Cacna1a)
CCAN: 109681262(Cacna1a)
OCU: 100009265(CACNA1A)
TUP: 102473903(CACNA1A)
CFA: 100686650(CACNA1A)
VVP: 112908114(CACNA1A)
VLG: 121495291(CACNA1A)
AML: 100473951(CACNA1A)
UMR: 103682191
UAH: 113247199(CACNA1A)
ORO: 101378448(CACNA1A)
ELK: 111162543
MPUF: 101674676(CACNA1A)
EJU: 114197735(CACNA1A)
MLX: 118005966(CACNA1A)
FCA: 101094827(CACNA1A)
PTG: 102962991(CACNA1A)
PPAD: 109254011(CACNA1A)
AJU: 106986103(CACNA1A)
HHV: 120245276(CACNA1A)
BTA: 282648(CACNA1A)
BOM: 102266763(CACNA1A)
BIU: 109560900(CACNA1A)
BBUB: 102404131(CACNA1A)
CHX: 102168441(CACNA1A)
OAS: 101120920(CACNA1A)
ODA: 120864066(CACNA1A)
SSC: 100525387(CACNA1A)
CFR: 102516820(CACNA1A)
CDK: 105100784(CACNA1A)
BACU: 103007483(CACNA1A)
LVE: 103068318(CACNA1A)
OOR: 101275783(CACNA1A)
DLE: 111166727(CACNA1A)
PCAD: 102977865(CACNA1A)
ECB: 100063873(CACNA1A)
EPZ: 103566268(CACNA1A)
EAI: 106844288(CACNA1A)
MYB: 102257882(CACNA1A)
MYD: 102771143(CACNA1A)
MMYO: 118652720(CACNA1A)
MNA: 107541038(CACNA1A)
HAI: 109394251(CACNA1A)
DRO: 112301443(CACNA1A)
SHON: 118984103(CACNA1A)
AJM: 119049676(CACNA1A)
MMF: 118615449(CACNA1A)
PALE: 102891789(CACNA1A)
RAY: 107519399(CACNA1A)
MJV: 108399643(CACNA1A)
TOD: 119241018(CACNA1A)
LAV: 100655176(CACNA1A)
TMU: 101341628
MDO: 100021108(CACNA1A)
SHR: 100925240(CACNA1A)
PCW: 110214234(CACNA1A)
OAA: 100078981(CACNA1A)
GGA: 107049790
LSR: 110481525(CACNA1A)
PMOA: 120506097(CACNA1A)
PHI: 102099919(CACNA1A)
ETL: 114072531(CACNA1A)
FPG: 101919186(CACNA1A)
ASN: 102376033(CACNA1A)
AMJ: 102564806(CACNA1A)
CMY: 102933709(CACNA1A)
CPIC: 101943820(CACNA1A)
TST: 117888655(CACNA1A)
CABI: 116817734(CACNA1A)
ACS: 100557580(cacna1a)
PVT: 110082653(CACNA1A)
PBI: 103050605(CACNA1A)
PMUR: 107286895(CACNA1A)
TSR: 106547348(CACNA1A)
PGUT: 117658819(CACNA1A)
PMUA: 114590816(CACNA1A)
ZVI: 118079990(CACNA1A)
GJA: 107116856(CACNA1A)
XLA: 108710372 373828(cacna1a.S)
XTR: 100492135(cacna1a)
NPR: 108794965(CACNA1A)
DRE: 562059(cacna1aa) 569528(cacna1ab)
CCAR: 109060317
PHYP: 113523781(cacna1a) 113525358
TRU: 101065285 101072720(cacna1a)
LCO: 104936743 109138994(cacna1a)
ELY: 117254987(cacna1ab) 117268021(cacna1aa)
PLEP: 121942442(cacna1ab) 121956459(cacna1aa)
SLUC: 116042548(cacna1ab) 116051851(cacna1aa)
ECRA: 117958666(cacna1aa) 117961643(cacna1ab)
PFLV: 114546705(cacna1a) 114569401
GAT: 120827313(cacna1aa)
MSAM: 119887893(cacna1aa) 119898592(cacna1ab)
CUD: 121503961(cacna1aa) 121508767(cacna1ab)
MZE: 101480217 101484868(cacna1a)
ONL: 100694261 100709811(cacna1a)
OAU: 116326122(cacna1ab) 116329204
OLA: 101170273 105357443(cacna1a)
OML: 112141681(cacna1ab) 112146767(cacna1aa)
XMA: 102225112 102236322(cacna1a)
XCO: 114145343(cacna1a) 114159632
XHE: 116720012(cacna1a) 116735966
PRET: 103462507(cacna1a) 103468620
CTUL: 119772641(cacna1aa) 119786986(cacna1ab)
NFU: 107376625 107391184(cacna1a)
KMR: 108239282(cacna1aa) 108247309(cacna1ab)
ALIM: 106527230(cacna1a) 106535455
CSEM: 103383187(cacna1a) 103392961
LCF: 108880719 108880807(cacna1a)
SDU: 111227043 111235833(cacna1a)
XGL: 120785766(cacna1aa) 120800346(cacna1ab)
BPEC: 110156590(cacna1a)
MALB: 109970352(cacna1a)
ELS: 105012190(cacna1a) 105024166
SFM: 108927499(cacna1a) 108930696
PKI: 111843226 111845281(cacna1a)
LOC: 102693691(cacna1a)
PSPA: 121304484(cacna1ab)
LCM: 102354855(CACNA1A)
RTP: 109912552
SPU: 574743
SKO: 100373523
DER: 6551177
PGC: 109856977
CRG: 105322251
 » show all
Reference
  Authors
Rose SJ, Kriener LH, Heinzer AK, Fan X, Raike RS, van den Maagdenberg AM, Hess EJ
  Title
The first knockin mouse model of episodic ataxia type 2.
  Journal
Exp Neurol 261:553-62 (2014)
DOI:10.1016/j.expneurol.2014.08.001
  Sequence
[hsa:773]
Reference
  Authors
Hans M, Urrutia A, Deal C, Brust PF, Stauderman K, Ellis SB, Harpold MM, Johnson EC, Williams ME
  Title
Structural elements in domain IV that influence biophysical and pharmacological properties of human alpha1A-containing high-voltage-activated calcium channels.
  Journal
Biophys J 76:1384-400 (1999)
DOI:10.1016/S0006-3495(99)77300-5
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