KEGG   PATHWAY: ajm04621
Entry
ajm04621                    Pathway                                
Name
NOD-like receptor signaling pathway - Artibeus jamaicensis (Jamaican fruit-eating bat)
Description
Specific families of pattern recognition receptors are responsible for detecting various pathogens and generating innate immune responses. The intracellular NOD-like receptor (NLR) family contains more than 20 members in mammals and plays a pivotal role in the recognition of intracellular ligands. NOD1 and NOD2, two prototypic NLRs, sense the cytosolic presence of the bacterial peptidoglycan fragments that escaped from endosomal compartments, driving the activation of NF-{kappa}B and MAPK, cytokine production and apoptosis. On the other hand, a different set of NLRs induces caspase-1 activation through the assembly of multiprotein complexes called inflammasomes. The activated of caspase-1 regulates maturation of the pro-inflammatory cytokines IL-1B, IL-18 and drives pyroptosis.
Class
Organismal Systems; Immune system
Pathway map
ajm04621  NOD-like receptor signaling pathway
ajm04621

Organism
Artibeus jamaicensis (Jamaican fruit-eating bat) [GN:ajm]
Gene
119035221  NOD1; nucleotide-binding oligomerization domain-containing protein 1 isoform X1 [KO:K08727]
119047894  RIPK2; receptor-interacting serine/threonine-protein kinase 2 [KO:K08846] [EC:2.7.11.1]
119053789  IKBKG; NF-kappa-B essential modulator isoform X1 [KO:K07210]
119064546  CHUK; inhibitor of nuclear factor kappa-B kinase subunit alpha [KO:K04467] [EC:2.7.11.10]
119047140  IKBKB; inhibitor of nuclear factor kappa-B kinase subunit beta isoform X1 [KO:K07209] [EC:2.7.11.10]
119040143  NFKBIB; NF-kappa-B inhibitor beta [KO:K02581]
119062929  NFKBIA; NF-kappa-B inhibitor alpha [KO:K04734]
119057921  NFKB1; nuclear factor NF-kappa-B p105 subunit isoform X1 [KO:K02580]
119050282  RELA; transcription factor p65 [KO:K04735]
119045049  interleukin-1 beta-like [KO:K04519]
119065847  IL1B; interleukin-1 beta [KO:K04519]
119056534  IL18; interleukin-18 [KO:K05482]
119042560  IL6; interleukin-6 isoform X1 [KO:K05405]
119053704  TNF; tumor necrosis factor isoform X1 [KO:K03156]
119052814  CXCL8; interleukin-8 [KO:K10030]
119052819  C-X-C motif chemokine 15-like [KO:K10030]
119059310  growth-regulated protein homolog gamma-like [KO:K05505]
119052818  growth-regulated protein homolog isoform X1 [KO:K05505]
119036306  monocyte chemotactic protein 1B-like isoform X1 [KO:K14624]
119065296  CCL5; C-C motif chemokine 5 [KO:K12499]
119036638  cathelicidin antimicrobial peptide [KO:K13916]
119058924  beta-defensin 103A-like [KO:K23126]
119046462  NOD2; nucleotide-binding oligomerization domain-containing protein 2 isoform X1 [KO:K10165]
119041421  mitogen-activated protein kinase kinase kinase 7 isoform X1 [KO:K04427] [EC:2.7.11.25]
119060232  TAB1; TGF-beta-activated kinase 1 and MAP3K7-binding protein 1 isoform X1 [KO:K04403]
119057909  TAB2; TGF-beta-activated kinase 1 and MAP3K7-binding protein 2 isoform X1 [KO:K04404]
119035636  TAB3; TGF-beta-activated kinase 1 and MAP3K7-binding protein 3 [KO:K12793]
119040930  MAPK3; mitogen-activated protein kinase 3 [KO:K04371] [EC:2.7.11.24]
119059157  MAPK1; mitogen-activated protein kinase 1 [KO:K04371] [EC:2.7.11.24]
119042614  MAPK9; mitogen-activated protein kinase 9 isoform X1 [KO:K04440] [EC:2.7.11.24]
119046845  MAPK8; mitogen-activated protein kinase 8 isoform X1 [KO:K04440] [EC:2.7.11.24]
119062834  MAPK10; mitogen-activated protein kinase 10 [KO:K04440] [EC:2.7.11.24]
119060490  MAPK12; mitogen-activated protein kinase 12 isoform X1 [KO:K04441] [EC:2.7.11.24]
119060539  MAPK11; mitogen-activated protein kinase 11 isoform X1 [KO:K04441] [EC:2.7.11.24]
119050071  MAPK14; mitogen-activated protein kinase 14 isoform X1 [KO:K04441] [EC:2.7.11.24]
119050081  MAPK13; mitogen-activated protein kinase 13 [KO:K04441] [EC:2.7.11.24]
119051654  JUN; transcription factor AP-1 [KO:K04448]
119048303  ATG16L1; autophagy-related protein 16-1 isoform X1 [KO:K17890]
119059370  ATG5; autophagy protein 5 isoform X1 [KO:K08339]
119046662  ATG12; ubiquitin-like protein ATG12 isoform X1 [KO:K08336]
119037145  gamma-aminobutyric acid receptor-associated protein [KO:K08341]
119048917  GABARAPL2; gamma-aminobutyric acid receptor-associated protein-like 2 [KO:K08341]
119065688  GABARAPL1; gamma-aminobutyric acid receptor-associated protein-like 1 [KO:K08341]
119053393  MAP1LC3C; microtubule-associated proteins 1A/1B light chain 3C [KO:K10435]
119047056  MAP1LC3B; microtubule-associated proteins 1A/1B light chain 3B [KO:K10435]
119063229  MAP1LC3A; microtubule-associated proteins 1A/1B light chain 3A [KO:K10435]
119038718  protein SGT1 homolog [KO:K12795]
119053017  protein SGT1 homolog [KO:K12795]
119046287  SUGT1; protein SGT1 homolog [KO:K12795]
119064715  sharpin [KO:K20894]
119047780  RBCK1; ranBP-type and C3HC4-type zinc finger-containing protein 1 [KO:K10630] [EC:2.3.2.31]
119047782  ranBP-type and C3HC4-type zinc finger-containing protein 1-like [KO:K10630] [EC:2.3.2.31]
119037290  RNF31; E3 ubiquitin-protein ligase RNF31 isoform X1 [KO:K11974] [EC:2.3.2.31]
119055846  E3 ubiquitin-protein ligase XIAP [KO:K04725] [EC:2.3.2.27]
119044250  CARD6; caspase recruitment domain-containing protein 6 [KO:K12797]
119041585  TRIP6; thyroid receptor-interacting protein 6 [KO:K12792]
119053311  ERBIN; erbin isoform X1 [KO:K12796]
119054065  BIRC3; baculoviral IAP repeat-containing protein 3 [KO:K16060]
119054066  BIRC2; baculoviral IAP repeat-containing protein 2 [KO:K16060]
119036073  TRAF2; TNF receptor-associated factor 2 isoform X1 [KO:K03173] [EC:2.3.2.27]
119043073  TRAF5; TNF receptor-associated factor 5 isoform X1 [KO:K09849]
119036455  TRAF6; TNF receptor-associated factor 6 [KO:K03175] [EC:2.3.2.27]
119036124  CARD9; caspase recruitment domain-containing protein 9 [KO:K12794]
119051859  TNFAIP3; tumor necrosis factor alpha-induced protein 3 isoform X1 [KO:K11859] [EC:3.4.19.12]
119051154  MAVS; mitochondrial antiviral-signaling protein [KO:K12648]
119037870  TRAF3; TNF receptor-associated factor 3 isoform X1 [KO:K03174]
119045546  TBK1; serine/threonine-protein kinase TBK1 [KO:K05410] [EC:2.7.11.10]
119056820  IKBKE; inhibitor of nuclear factor kappa-B kinase subunit epsilon isoform X1 [KO:K07211] [EC:2.7.11.10]
119045646  TANK; TRAF family member-associated NF-kappa-B activator isoform X1 [KO:K12650]
119045996  IRF3; interferon regulatory factor 3 isoform X1 [KO:K05411]
119062180  IRF7; interferon regulatory factor 7 isoform X1 [KO:K09447]
119058844  interferon alpha-4-like [KO:K05414]
119045866  interferon alpha-7 [KO:K05414]
119045867  interferon alpha-4 [KO:K05414]
119056303  interferon alpha-4-like [KO:K05414]
119049818  interferon alpha-4-like [KO:K05414]
119055662  IFNB1; interferon beta [KO:K05415]
119050747  NLRX1; NLR family member X1 isoform X1 [KO:K12653]
119035795  anthrax toxin receptor 1 [KO:K20909]
119056954  ANTXR2; anthrax toxin receptor 2 [KO:K20909]
119048592  LOW QUALITY PROTEIN: NACHT, LRR and PYD domains-containing protein 1-like [KO:K12798]
119048614  NACHT, LRR and PYD domains-containing protein 1-like isoform X1 [KO:K12798]
119057665  NACHT, LRR and PYD domains-containing protein 1-like [KO:K12798]
119036945  apoptosis-associated speck-like protein containing a CARD [KO:K12799]
119038029  PYCARD; apoptosis-associated speck-like protein containing a CARD [KO:K12799]
119051385  apoptosis-associated speck-like protein containing a CARD isoform X1 [KO:K12799]
119060758  CASP1; caspase-1 isoform X1 [KO:K01370] [EC:3.4.22.36]
119057575  BCL2; apoptosis regulator Bcl-2 isoform X1 [KO:K02161]
119047720  BCL2L1; bcl-2-like protein 1 [KO:K04570]
119039364  cathepsin B-like protease 2 [KO:K01363] [EC:3.4.22.1]
119049448  CTSB; cathepsin B isoform X1 [KO:K01363] [EC:3.4.22.1]
119051579  NLRP3; NACHT, LRR and PYD domains-containing protein 3 isoform X1 [KO:K12800]
119055792  PANX1; pannexin-1 [KO:K03443]
119048815  P2RX7; P2X purinoceptor 7 isoform X1 [KO:K05220]
119058737  TRPM2; transient receptor potential cation channel subfamily M member 2 isoform X1 [KO:K04977] [EC:3.6.1.13]
119057606  TRPM7; transient receptor potential cation channel subfamily M member 7 isoform X1 [KO:K04982] [EC:2.7.11.1]
119064351  TRPV2; transient receptor potential cation channel subfamily V member 2 [KO:K04971]
119046980  CASR; extracellular calcium-sensing receptor [KO:K04612]
119058708  GPRC6A; G-protein coupled receptor family C group 6 member A [KO:K04622]
119045446  PLCB3; 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-3 [KO:K05858] [EC:3.1.4.11]
119061296  PLCB2; 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-2 [KO:K05858] [EC:3.1.4.11]
119057282  PLCB1; 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-1 isoform X1 [KO:K05858] [EC:3.1.4.11]
119036740  ITPR1; inositol 1,4,5-trisphosphate receptor type 1 [KO:K04958]
119048995  ITPR2; inositol 1,4,5-trisphosphate receptor type 2 isoform X1 [KO:K04959]
119041225  ITPR3; inositol 1,4,5-trisphosphate receptor type 3 [KO:K04960]
119037617  VDAC1; voltage-dependent anion-selective channel protein 1 [KO:K05862]
119038134  VDAC2; voltage-dependent anion-selective channel protein 2 [KO:K15040]
119053810  LOW QUALITY PROTEIN: voltage-dependent anion-selective channel protein 2-like [KO:K15040]
119047138  VDAC3; voltage-dependent anion-selective channel protein 3 isoform X1 [KO:K15041]
119038081  MCU; calcium uniporter protein, mitochondrial isoform X1 [KO:K20858]
119040446  OAS3; 2'-5'-oligoadenylate synthase 3 isoform X1 [KO:K14216] [EC:2.7.7.84]
119040447  OAS1; 2'-5'-oligoadenylate synthase 1 [KO:K14216] [EC:2.7.7.84]
119040463  OAS2; LOW QUALITY PROTEIN: 2'-5'-oligoadenylate synthase 2 [KO:K14216] [EC:2.7.7.84]
119056133  2'-5'-oligoadenylate synthase 1-like [KO:K14216] [EC:2.7.7.84]
119049606  RNASEL; 2-5A-dependent ribonuclease isoform X1 [KO:K01165]
119048611  DHX33; ATP-dependent RNA helicase DHX33 [KO:K17820] [EC:5.6.2.6]
119042998  MFN1; mitofusin-1 isoform X1 [KO:K21356] [EC:3.6.5.-]
119064110  MFN2; mitofusin-2 [KO:K06030] [EC:3.6.5.-]
119051788  RIPK1; receptor-interacting serine/threonine-protein kinase 1 isoform X1 [KO:K02861] [EC:2.7.11.1]
119037319  RIPK3; LOW QUALITY PROTEIN: receptor-interacting serine/threonine-protein kinase 3 [KO:K08847] [EC:2.7.11.1]
119045100  DNM1L; dynamin-1-like protein isoform X1 [KO:K17065] [EC:3.6.5.5]
119053046  NAMPT; nicotinamide phosphoribosyltransferase isoform X1 [KO:K03462] [EC:2.4.2.12]
119063653  cytochrome b-245 heavy chain [KO:K21421] [EC:1.-.-.-]
119047041  cytochrome b-245 light chain isoform X1 [KO:K08009]
119049409  thioredoxin-interacting protein [KO:K20910]
119060402  TXN2; thioredoxin, mitochondrial isoform X1 [KO:K03671]
119045416  thioredoxin H2-like [KO:K03671]
119045417  thioredoxin H2-like [KO:K03671]
119054719  TXN; thioredoxin [KO:K03671]
119062361  thioredoxin-3, mitochondrial-like [KO:K03671]
119053368  NEK7; serine/threonine-protein kinase Nek7 [KO:K20876] [EC:2.7.11.34]
119055506  BRCC3; lys-63-specific deubiquitinase BRCC36 isoform X1 [KO:K11864] [EC:3.4.19.-]
119037939  HSP90AA1; heat shock protein HSP 90-alpha [KO:K04079]
119041136  LOW QUALITY PROTEIN: putative heat shock protein HSP 90-beta-3 [KO:K04079]
119046156  heat shock protein 90-5, chloroplastic-like [KO:K04079]
119061428  endoplasmin homolog [KO:K04079]
119047198  HSP90AB1; heat shock protein HSP 90-beta [KO:K04079]
119047665  heat shock protein 81-1 [KO:K04079]
119053743  GPSM3; G-protein-signaling modulator 3 [KO:K15838]
119038032  PYDC1; pyrin domain-containing protein 1 [KO:K12802]
119056265  MEFV; pyrin [KO:K12803]
119038683  PSTPIP1; proline-serine-threonine phosphatase-interacting protein 1 isoform X1 [KO:K12804]
119065511  CASP8; caspase-8 [KO:K04398] [EC:3.4.22.61]
119041863  FADD; FAS-associated death domain protein [KO:K02373]
119060799  caspase-12-like [KO:K04741] [EC:3.4.22.-]
119060749  CARD16; caspase recruitment domain-containing protein 16 [KO:K12806]
119060966  NLRP6; NACHT, LRR and PYD domains-containing protein 6 isoform X1 [KO:K20863]
119059975  NACHT, LRR and PYD domains-containing protein 2-like [KO:K20864]
119058920  NLRP12; NACHT, LRR and PYD domains-containing protein 12 isoform X1 [KO:K20865]
119037382  baculoviral IAP repeat-containing protein 1 [KO:K12807]
119052078  baculoviral IAP repeat-containing protein 1 [KO:K12807]
119050344  NLRC4; NLR family CARD domain-containing protein 4 isoform X1 [KO:K12805]
119041430  PRKCD; protein kinase C delta type [KO:K06068] [EC:2.7.11.13]
119042758  guanylate-binding protein 2-like [KO:K20897]
119056095  GBP5; guanylate-binding protein 5 isoform X1 [KO:K20898]
119056495  TP53BP1; TP53-binding protein 1 isoform X1 [KO:K20915]
119036699  RHOA; transforming protein RhoA [KO:K04513]
119059816  transforming protein RhoA-like [KO:K04513]
119047326  LOW QUALITY PROTEIN: transforming protein RhoA-like [KO:K04513]
119049697  PKN1; serine/threonine-protein kinase N1 [KO:K06071] [EC:2.7.11.13]
119042752  PKN2; serine/threonine-protein kinase N2 isoform X1 [KO:K23691] [EC:2.7.11.13]
119040658  YWHAE; 14-3-3 protein epsilon [KO:K06630]
119059234  14-3-3-like protein B [KO:K06630]
119059235  14-3-3-like protein B [KO:K06630]
119047645  14-3-3-like protein GF14-A [KO:K06630]
119056042  14-3-3-like protein GF14-D [KO:K06630]
119042740  LOW QUALITY PROTEIN: guanylate-binding protein 7-like [KO:K20899]
119042748  GBP1; guanylate-binding protein 1 [KO:K20899]
119042768  guanylate-binding protein 7-like [KO:K20899]
119060734  caspase-13-like isoform X1 [KO:K04394] [EC:3.4.22.57 3.4.22.64]
119060770  caspase-1-like isoform X1 [KO:K04394] [EC:3.4.22.57 3.4.22.64]
119060787  caspase-13-like isoform X1 [KO:K04394] [EC:3.4.22.57 3.4.22.64]
119064645  GSDMD; gasdermin-D [KO:K20917]
119035720  IFNAR1; interferon alpha/beta receptor 1 [KO:K05130]
119035719  IFNAR2; interferon alpha/beta receptor 2 isoform X1 [KO:K05131]
119042494  JAK1; tyrosine-protein kinase JAK1 [KO:K11217] [EC:2.7.10.2]
119055683  non-receptor tyrosine-protein kinase TYK2-like [KO:K11219] [EC:2.7.10.2]
119062093  STAT1; signal transducer and activator of transcription 1-alpha/beta isoform X1 [KO:K11220]
119040310  STAT2; signal transducer and activator of transcription 2 [KO:K11221]
119037294  IRF9; interferon regulatory factor 9 [KO:K04693]
119056324  TLR4; toll-like receptor 4 isoform X1 [KO:K10160]
119063741  TICAM1; TIR domain-containing adapter molecule 1 [KO:K05842]
119051446  MYD88; myeloid differentiation primary response protein MyD88 isoform X1 [KO:K04729]
119061695  IRAK4; interleukin-1 receptor-associated kinase 4 isoform X1 [KO:K04733] [EC:2.7.11.1]
119050990  STING1; stimulator of interferon genes protein [KO:K12654]
Compound
C00002  ATP
C00076  Calcium cation
C00155  L-Homocysteine
C00238  Potassium cation
C00533  Nitric oxide
C01245  D-myo-Inositol 1,4,5-trisphosphate
Reference
PMID:23124073
  Authors
Vandenabeele P, Bertrand MJ
  Title
The role of the IAP E3 ubiquitin ligases in regulating pattern-recognition receptor signalling.
  Journal
Nat Rev Immunol 12:833-44 (2012)
DOI:10.1038/nri3325
Reference
PMID:16493424
  Authors
Strober W, Murray PJ, Kitani A, Watanabe T
  Title
Signalling pathways and molecular interactions of NOD1 and NOD2.
  Journal
Nat Rev Immunol 6:9-20 (2006)
DOI:10.1038/nri1747
Reference
PMID:24718315
  Authors
Estornes Y, Bertrand MJ
  Title
IAPs, regulators of innate immunity and inflammation.
  Journal
Semin Cell Dev Biol 39:106-14 (2015)
DOI:10.1016/j.semcdb.2014.03.035
Reference
PMID:24707857
  Authors
Jakopin Z
  Title
Nucleotide-binding oligomerization domain (NOD) inhibitors: a rational approach toward inhibition of NOD signaling pathway.
  Journal
J Med Chem 57:6897-918 (2014)
DOI:10.1021/jm401841p
Reference
PMID:25526305
  Authors
Caruso R, Warner N, Inohara N, Nunez G
  Title
NOD1 and NOD2: signaling, host defense, and inflammatory disease.
  Journal
Immunity 41:898-908 (2014)
DOI:10.1016/j.immuni.2014.12.010
Reference
PMID:19767725
  Authors
Murray PJ
  Title
Beyond peptidoglycan for Nod2.
  Journal
Nat Immunol 10:1053-4 (2009)
DOI:10.1038/ni1009-1053
Reference
PMID:20643110
  Authors
Lecat A, Piette J, Legrand-Poels S
  Title
The protein Nod2: an innate receptor more complex than previously assumed.
  Journal
Biochem Pharmacol 80:2021-31 (2010)
DOI:10.1016/j.bcp.2010.07.016
Reference
PMID:26655628
  Authors
Man SM, Kanneganti TD
  Title
Converging roles of caspases in inflammasome activation, cell death and innate immunity.
  Journal
Nat Rev Immunol 16:7-21 (2016)
DOI:10.1038/nri.2015.7
Reference
PMID:27291964
  Authors
Broz P, Dixit VM
  Title
Inflammasomes: mechanism of assembly, regulation and signalling.
  Journal
Nat Rev Immunol 16:407-20 (2016)
DOI:10.1038/nri.2016.58
Reference
PMID:25879280
  Authors
Man SM, Kanneganti TD
  Title
Regulation of inflammasome activation.
  Journal
Immunol Rev 265:6-21 (2015)
DOI:10.1111/imr.12296
Reference
PMID:26549800
  Authors
Jo EK, Kim JK, Shin DM, Sasakawa C
  Title
Molecular mechanisms regulating NLRP3 inflammasome activation.
  Journal
Cell Mol Immunol 13:148-59 (2016)
DOI:10.1038/cmi.2015.95
Reference
PMID:23846113
  Authors
Broz P, Monack DM
  Title
Newly described pattern recognition receptors team up against intracellular pathogens.
  Journal
Nat Rev Immunol 13:551-65 (2013)
DOI:10.1038/nri3479
Reference
PMID:22430786
  Authors
Rathinam VA, Vanaja SK, Fitzgerald KA
  Title
Regulation of inflammasome signaling.
  Journal
Nat Immunol 13:333-42 (2012)
DOI:10.1038/ni.2237
Reference
PMID:24840700
  Authors
Sutterwala FS, Haasken S, Cassel SL
  Title
Mechanism of NLRP3 inflammasome activation.
  Journal
Ann N Y Acad Sci 1319:82-95 (2014)
DOI:10.1111/nyas.12458
Reference
PMID:23702978
  Authors
Latz E, Xiao TS, Stutz A
  Title
Activation and regulation of the inflammasomes.
  Journal
Nat Rev Immunol 13:397-411 (2013)
DOI:10.1038/nri3452
Reference
PMID:25145756
  Authors
Blander JM
  Title
A long-awaited merger of the pathways mediating host defence and programmed cell death.
  Journal
Nat Rev Immunol 14:601-18 (2014)
DOI:10.1038/nri3720
Reference
PMID:23215645
  Authors
von Moltke J, Ayres JS, Kofoed EM, Chavarria-Smith J, Vance RE
  Title
Recognition of bacteria by inflammasomes.
  Journal
Annu Rev Immunol 31:73-106 (2013)
DOI:10.1146/annurev-immunol-032712-095944
Reference
PMID:25330206
  Authors
Abais JM, Xia M, Zhang Y, Boini KM, Li PL
  Title
Redox regulation of NLRP3 inflammasomes: ROS as trigger or effector?
  Journal
Antioxid Redox Signal 22:1111-29 (2015)
DOI:10.1089/ars.2014.5994
Reference
PMID:25879288
  Authors
Storek KM, Monack DM
  Title
Bacterial recognition pathways that lead to inflammasome activation.
  Journal
Immunol Rev 265:112-29 (2015)
DOI:10.1111/imr.12289
Reference
PMID:27012466
  Authors
Hu H, Sun SC
  Title
Ubiquitin signaling in immune responses.
  Journal
Cell Res 26:457-83 (2016)
DOI:10.1038/cr.2016.40
Reference
PMID:26121197
  Authors
Guo H, Callaway JB, Ting JP
  Title
Inflammasomes: mechanism of action, role in disease, and therapeutics.
  Journal
Nat Med 21:677-87 (2015)
DOI:10.1038/nm.3893
Reference
PMID:26482951
  Authors
Man SM, Kanneganti TD
  Title
Gasdermin D: the long-awaited executioner of pyroptosis.
  Journal
Cell Res 25:1183-4 (2015)
DOI:10.1038/cr.2015.124
Reference
PMID:22819539
  Authors
Rathinam VA, Vanaja SK, Waggoner L, Sokolovska A, Becker C, Stuart LM, Leong JM, Fitzgerald KA
  Title
TRIF licenses caspase-11-dependent NLRP3 inflammasome activation by gram-negative bacteria.
  Journal
Cell 150:606-19 (2012)
DOI:10.1016/j.cell.2012.07.007
Reference
PMID:21575908
  Authors
Kerur N, Veettil MV, Sharma-Walia N, Bottero V, Sadagopan S, Otageri P, Chandran B
  Title
IFI16 acts as a nuclear pathogen sensor to induce the inflammasome in response to Kaposi Sarcoma-associated herpesvirus infection.
  Journal
Cell Host Microbe 9:363-75 (2011)
DOI:10.1016/j.chom.2011.04.008
Reference
PMID:29148036
  Authors
Heilig R, Broz P
  Title
Function and mechanism of the pyrin inflammasome.
  Journal
Eur J Immunol 48:230-238 (2018)
DOI:10.1002/eji.201746947
Reference
PMID:25816776
  Authors
Chakrabarti A, Banerjee S, Franchi L, Loo YM, Gale M Jr, Nunez G, Silverman RH
  Title
RNase L activates the NLRP3 inflammasome during viral infections.
  Journal
Cell Host Microbe 17:466-77 (2015)
DOI:10.1016/j.chom.2015.02.010
Related
pathway
ajm04010  MAPK signaling pathway
ajm04064  NF-kappa B signaling pathway
ajm04140  Autophagy - animal
ajm04620  Toll-like receptor signaling pathway
KO pathway
ko04621   
LinkDB

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