KEGG   PATHWAY: bbis04380
Entry
bbis04380                   Pathway                                
Name
Osteoclast differentiation - Bison bison bison (American bison)
Description
The osteoclasts, multinucleared cells originating from the hematopoietic monocyte-macrophage lineage, are responsible for bone resorption. Osteoclastogenesis is mainly regulated by signaling pathways activated by RANK and immune receptors, whose ligands are expressed on the surface of osteoblasts. Signaling from RANK changes gene expression patterns through transcription factors like NFATc1 and characterizes the active osteoclast.
Class
Organismal Systems; Development and regeneration
Pathway map
bbis04380  Osteoclast differentiation
bbis04380

Other DBs
GO: 0030316
Organism
Bison bison bison (American bison) [GN:bbis]
Gene
104979784  ACP5; tartrate-resistant acid phosphatase type 5 [KO:K14379] [EC:3.1.3.2]
104979826  TYK2; non-receptor tyrosine-protein kinase TYK2 [KO:K11219] [EC:2.7.10.2]
104979935  MAP2K7; dual specificity mitogen-activated protein kinase kinase 7 [KO:K04431] [EC:2.7.12.2]
104980851  IL1R1; interleukin-1 receptor type 1 [KO:K04386]
104980869  FHL2; four and a half LIM domains protein 2 [KO:K14380]
104981526  MAPK9; mitogen-activated protein kinase 9 isoform X1 [KO:K04440] [EC:2.7.11.24]
104981529  SQSTM1; sequestosome-1 [KO:K14381]
104981661  CSF1; macrophage colony-stimulating factor 1 isoform X1 [KO:K05453]
104981967  MAPK12; mitogen-activated protein kinase 12 [KO:K04441] [EC:2.7.11.24]
104981977  MAPK11; mitogen-activated protein kinase 11 [KO:K04441] [EC:2.7.11.24]
104982030  IRF9; interferon regulatory factor 9 [KO:K04693]
104982477  TRAF6; TNF receptor-associated factor 6 [KO:K03175] [EC:2.3.2.27]
104982944  TRAF2; TNF receptor-associated factor 2 [KO:K03173] [EC:2.3.2.27]
104982962  MAP3K14; mitogen-activated protein kinase kinase kinase 14 [KO:K04466] [EC:2.7.11.25]
104983545  BLNK; B-cell linker protein isoform X1 [KO:K07371]
104983695  [KO:K05415]
104983770  TNF; tumor necrosis factor isoform X1 [KO:K03156]
104984376  [KO:K06512]
104984378  [KO:K06512]
104984411  IL1B; interleukin-1 beta [KO:K04519]
104984413  IL1A; interleukin-1 alpha [KO:K04383]
104984678  MAP2K1; dual specificity mitogen-activated protein kinase kinase 1 isoform X1 [KO:K04368] [EC:2.7.12.2]
104984790  MAP3K7; mitogen-activated protein kinase kinase kinase 7 isoform X1 [KO:K04427] [EC:2.7.11.25]
104985118  NFATC2; LOW QUALITY PROTEIN: nuclear factor of activated T-cells, cytoplasmic 2 [KO:K17332]
104985207  OSCAR; osteoclast-associated immunoglobulin-like receptor [KO:K06512]
104985237  NFKBIA; NF-kappa-B inhibitor alpha [KO:K04734]
104985407  TGFBR2; TGF-beta receptor type-2 [KO:K04388] [EC:2.7.11.30]
104985678  SYK; tyrosine-protein kinase SYK isoform X1 [KO:K05855] [EC:2.7.10.2]
104986090  SIRPB1; signal-regulatory protein beta-1 [KO:K06551]
104986091  [KO:K06551]
104986185  SIRPA; tyrosine-protein phosphatase non-receptor type substrate 1 [KO:K06551]
104986245  [KO:K04456] [EC:2.7.11.1]
104986363  LILRA6; leukocyte immunoglobulin-like receptor subfamily A member 6 [KO:K06512]
104986377  LCK; tyrosine-protein kinase Lck [KO:K05856] [EC:2.7.10.2]
104986380  [KO:K06512]
104986516  [KO:K06512]
104986612  ATP2A1; sarcoplasmic/endoplasmic reticulum calcium ATPase 1 [KO:K05853] [EC:7.2.2.10]
104986748  MAPK3; mitogen-activated protein kinase 3 [KO:K04371] [EC:2.7.11.24]
104987017  FOSL1; fos-related antigen 1 [KO:K04502]
104987029  RELA; transcription factor p65 [KO:K04735]
104987657  CTSK; cathepsin K [KO:K01371] [EC:3.4.22.38]
104987702  [KO:K06498]
104988072  STAT2; signal transducer and activator of transcription 2 isoform X1 [KO:K11221]
104988449  CALCR; calcitonin receptor [KO:K04576]
104988726  JAK1; tyrosine-protein kinase JAK1 [KO:K11217] [EC:2.7.10.2]
104989133  FOSL2; fos-related antigen 2 [KO:K09030]
104989626  ATP2A2; sarcoplasmic/endoplasmic reticulum calcium ATPase 2 isoform X1 [KO:K05853] [EC:7.2.2.10]
104989637  [KO:K04456] [EC:2.7.11.1]
104989779  IFNG; interferon gamma [KO:K04687]
104990392  SPI1; transcription factor PU.1 [KO:K09438]
104991474  [KO:K08009]
104991476  [KO:K06512]
104991589  ITPR1; inositol 1,4,5-trisphosphate receptor type 1 [KO:K04958]
104991667  IFNGR1; interferon gamma receptor 1 [KO:K05132]
104992083  PPP3R2; calcineurin subunit B type 2 [KO:K06268]
104992338  TNFRSF1A; tumor necrosis factor receptor superfamily member 1A [KO:K03158]
104992373  TAB1; TGF-beta-activated kinase 1 and MAP3K7-binding protein 1 [KO:K04403]
104992445  PPP3R1; calcineurin subunit B type 1 [KO:K06268]
104992549  PPP3CC; serine/threonine-protein phosphatase 2B catalytic subunit gamma isoform isoform X1 [KO:K04348] [EC:3.1.3.16]
104992716  [KO:K02649]
104992794  RAC1; ras-related C3 botulinum toxin substrate 1 [KO:K04392]
104992939  MAPK10; mitogen-activated protein kinase 10 isoform X1 [KO:K04440] [EC:2.7.11.24]
104993058  CAMK4; calcium/calmodulin-dependent protein kinase type IV [KO:K05869] [EC:2.7.11.17]
104993223  IKBKB; inhibitor of nuclear factor kappa-B kinase subunit beta isoform X1 [KO:K07209] [EC:2.7.11.10]
104993728  TGFBR1; TGF-beta receptor type-1 [KO:K04674] [EC:2.7.11.30]
104994008  ATP2A3; LOW QUALITY PROTEIN: sarcoplasmic/endoplasmic reticulum calcium ATPase 3 [KO:K05853] [EC:7.2.2.10]
104994333  PIK3R3; phosphatidylinositol 3-kinase regulatory subunit gamma isoform X1 [KO:K02649]
104994637  NFKB1; nuclear factor NF-kappa-B p105 subunit isoform X1 [KO:K02580]
104994644  PPP3CA; serine/threonine-protein phosphatase 2B catalytic subunit alpha isoform [KO:K04348] [EC:3.1.3.16]
104994938  MAPK14; mitogen-activated protein kinase 14 isoform X1 [KO:K04441] [EC:2.7.11.24]
104994939  MAPK13; mitogen-activated protein kinase 13 [KO:K04441] [EC:2.7.11.24]
104995001  ITPR3; LOW QUALITY PROTEIN: inositol 1,4,5-trisphosphate receptor type 3 [KO:K04960]
104995265  TYROBP; TYRO protein tyrosine kinase-binding protein isoform X1 [KO:K07992]
104995356  AKT2; RAC-beta serine/threonine-protein kinase [KO:K04456] [EC:2.7.11.1]
104995381  TGFB1; transforming growth factor beta-1 isoform X1 [KO:K13375]
104995620  [KO:K04371] [EC:2.7.11.24]
104996058  PIK3CD; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform [KO:K00922] [EC:2.7.1.153]
104996149  [KO:K05415]
104996310  CSF1R; macrophage colony-stimulating factor 1 receptor [KO:K05090] [EC:2.7.10.1]
104996518  PLCG2; 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-2 isoform X1 [KO:K05859] [EC:3.1.4.11]
104997505  PPP3CB; serine/threonine-protein phosphatase 2B catalytic subunit beta isoform isoform X1 [KO:K04348] [EC:3.1.3.16]
104997699  FOSB; protein fosB [KO:K09029]
104997770  RELB; LOW QUALITY PROTEIN: transcription factor RelB [KO:K09253]
104998082  NCF2; neutrophil cytosol factor 2 isoform X1 [KO:K08010]
104998160  GAB2; GRB2-associated-binding protein 2 [KO:K08091]
104998204  TGFB2; transforming growth factor beta-2 isoform X1 [KO:K13376]
104998445  PIK3R1; phosphatidylinositol 3-kinase regulatory subunit alpha isoform X1 [KO:K02649]
104998915  BTK; tyrosine-protein kinase BTK [KO:K07370] [EC:2.7.10.2]
104998946  NCF1; neutrophil cytosol factor 1 [KO:K08011]
104998999  MAPK8; mitogen-activated protein kinase 8 isoform X1 [KO:K04440] [EC:2.7.11.24]
104999097  LCP2; lymphocyte cytosolic protein 2 isoform X1 [KO:K07361]
104999126  TNFSF11; tumor necrosis factor ligand superfamily member 11 [KO:K05473]
104999183  FCGR2B; low affinity immunoglobulin gamma Fc region receptor II-b isoform X1 [KO:K12560]
104999186  [KO:K06463]
104999189  [KO:K06472]
104999276  TNFRSF11A; LOW QUALITY PROTEIN: tumor necrosis factor receptor superfamily member 11A [KO:K05147]
104999550  NFATC1; nuclear factor of activated T-cells, cytoplasmic 1 [KO:K04446]
104999603  CYLD; ubiquitin carboxyl-terminal hydrolase CYLD isoform X1 [KO:K08601] [EC:3.4.19.12]
104999904  JUNB; LOW QUALITY PROTEIN: transcription factor jun-B [KO:K09028]
104999978  PIK3CA; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform [KO:K00922] [EC:2.7.1.153]
105000057  FOS; proto-oncogene c-Fos [KO:K04379]
105000175  JUN; transcription factor AP-1 [KO:K04448]
105000232  ITPR2; inositol 1,4,5-trisphosphate receptor type 2 [KO:K04959]
105000295  MAP2K6; dual specificity mitogen-activated protein kinase kinase 6 isoform X1 [KO:K04433] [EC:2.7.12.2]
105000345  GRB2; growth factor receptor-bound protein 2 isoform X1 [KO:K04364]
105000519  ITGB3; integrin beta-3 isoform X1 [KO:K06493]
105000566  SOCS3; suppressor of cytokine signaling 3 [KO:K04696]
105000638  FYN; tyrosine-protein kinase Fyn isoform X1 [KO:K05703] [EC:2.7.10.2]
105000961  IFNB1; interferon beta [KO:K05415]
105000962  [KO:K05415]
105000963  [KO:K05415]
105001756  [KO:K06512]
105001774  [KO:K06512]
105001799  PIK3CB; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform [KO:K00922] [EC:2.7.1.153]
105002333  TEC; tyrosine-protein kinase Tec isoform X1 [KO:K07364] [EC:2.7.10.2]
105002676  NFKB2; nuclear factor NF-kappa-B p100 subunit isoform X1 [KO:K04469]
105002719  CHUK; inhibitor of nuclear factor kappa-B kinase subunit alpha isoform X1 [KO:K04467] [EC:2.7.11.10]
105003405  NCF4; neutrophil cytosol factor 4 isoform X1 [KO:K08012]
105003595  STAT1; signal transducer and activator of transcription 1-alpha/beta isoform X1 [KO:K11220]
105003597  [KO:K04456] [EC:2.7.11.1]
105003702  CREB1; cyclic AMP-responsive element-binding protein 1 isoform X1 [KO:K05870]
105004395  MITF; microphthalmia-associated transcription factor isoform X1 [KO:K09455]
105004566  TMEM64; transmembrane protein 64 [KO:K26770]
105004619  IFNGR2; interferon gamma receptor 2 [KO:K05133]
105004621  IFNAR1; interferon alpha/beta receptor 1 [KO:K05130]
105004624  IFNAR2; interferon alpha/beta receptor 2 [KO:K05131]
105004745  PPARG; peroxisome proliferator-activated receptor gamma isoform X1 [KO:K08530]
105004816  TAB2; TGF-beta-activated kinase 1 and MAP3K7-binding protein 2 [KO:K04404]
105005052  [KO:K06512]
105005061  [KO:K06512]
105005257  TREM2; triggering receptor expressed on myeloid cells 2 [KO:K14378]
105005434  TNFRSF11B; tumor necrosis factor receptor superfamily member 11B [KO:K05148]
Compound
C00027  Hydrogen peroxide
C00076  Calcium cation
C01245  D-myo-Inositol 1,4,5-trisphosphate
Reference
PMID:16313349
  Authors
Takayanagi H, Sato K, Takaoka A, Taniguchi T
  Title
Interplay between interferon and other cytokine systems in bone metabolism.
  Journal
Immunol Rev 208:181-93 (2005)
DOI:10.1111/j.0105-2896.2005.00337.x
Reference
PMID:20392226
  Authors
Takayanagi H
  Title
New immune connections in osteoclast formation.
  Journal
Ann N Y Acad Sci 1192:117-23 (2010)
DOI:10.1111/j.1749-6632.2009.05303.x
Reference
PMID:19585227
  Authors
Nakashima T, Takayanagi H
  Title
Osteoimmunology: crosstalk between the immune and bone systems.
  Journal
J Clin Immunol 29:555-67 (2009)
DOI:10.1007/s10875-009-9316-6
Reference
PMID:18722561
  Authors
Caetano-Lopes J, Canhao H, Fonseca JE
  Title
Osteoimmunology--the hidden immune regulation of bone.
  Journal
Autoimmun Rev 8:250-5 (2009)
DOI:10.1016/j.autrev.2008.07.038
Reference
PMID:18451259
  Authors
Lorenzo J, Horowitz M, Choi Y
  Title
Osteoimmunology: interactions of the bone and immune system.
  Journal
Endocr Rev 29:403-40 (2008)
DOI:10.1210/er.2007-0038
Reference
PMID:17869613
  Authors
David JP
  Title
Osteoimmunology: a view from the bone.
  Journal
Adv Immunol 95:149-65 (2007)
DOI:10.1016/S0065-2776(07)95005-1
Reference
PMID:16313342
  Authors
Jimi E, Ghosh S
  Title
Role of nuclear factor-kappaB in the immune system and bone.
  Journal
Immunol Rev 208:80-7 (2005)
DOI:10.1111/j.0105-2896.2005.00329.x
Reference
PMID:12748652
  Authors
Boyle WJ, Simonet WS, Lacey DL
  Title
Osteoclast differentiation and activation.
  Journal
Nature 423:337-42 (2003)
DOI:10.1038/nature01658
Reference
PMID:17633024
  Authors
Darnay BG, Besse A, Poblenz AT, Lamothe B, Jacoby JJ
  Title
TRAFs in RANK signaling.
  Journal
Adv Exp Med Biol 597:152-9 (2007)
DOI:10.1007/978-0-387-70630-6_12
Reference
PMID:15122243
  Authors
Baron R
  Title
Arming the osteoclast.
  Journal
Nat Med 10:458-60 (2004)
DOI:10.1038/nm0504-458
Reference
PMID:17380158
  Authors
Takayanagi H
  Title
Osteoimmunology: shared mechanisms and crosstalk between the immune and bone systems.
  Journal
Nat Rev Immunol 7:292-304 (2007)
DOI:10.1038/nri2062
Reference
PMID:20703218
  Authors
Krum SA, Chang J, Miranda-Carboni G, Wang CY
  Title
Novel functions for NFkappaB: inhibition of bone formation.
  Journal
Nat Rev Rheumatol 6:607-11 (2010)
DOI:10.1038/nrrheum.2010.133
Reference
PMID:15817678
  Authors
Lee NK, Choi YG, Baik JY, Han SY, Jeong DW, Bae YS, Kim N, Lee SY
  Title
A crucial role for reactive oxygen species in RANKL-induced osteoclast differentiation.
  Journal
Blood 106:852-9 (2005)
DOI:10.1182/blood-2004-09-3662
Reference
PMID:18329366
  Authors
Shinohara M, Koga T, Okamoto K, Sakaguchi S, Arai K, Yasuda H, Takai T, Kodama T, Morio T, Geha RS, Kitamura D, Kurosaki T, Ellmeier W, Takayanagi H
  Title
Tyrosine kinases Btk and Tec regulate osteoclast differentiation by linking RANK and ITAM signals.
  Journal
Cell 132:794-806 (2008)
DOI:10.1016/j.cell.2007.12.037
Reference
PMID:15546140
  Authors
Takayanagi H, Kim S, Koga T, Taniguchi T
  Title
Stat1-mediated cytoplasmic attenuation in osteoimmunology.
  Journal
J Cell Biochem 94:232-40 (2005)
DOI:10.1002/jcb.20316
Reference
PMID:18382763
  Authors
Jin W, Chang M, Paul EM, Babu G, Lee AJ, Reiley W, Wright A, Zhang M, You J, Sun SC
  Title
Deubiquitinating enzyme CYLD negatively regulates RANK signaling and osteoclastogenesis in mice.
  Journal
J Clin Invest 118:1858-66 (2008)
DOI:10.1172/JCI34257
Reference
PMID:16184196
  Authors
Bai S, Kitaura H, Zhao H, Chen J, Muller JM, Schule R, Darnay B, Novack DV, Ross FP, Teitelbaum SL
  Title
FHL2 inhibits the activated osteoclast in a TRAF6-dependent manner.
  Journal
J Clin Invest 115:2742-51 (2005)
DOI:10.1172/JCI24921
Reference
PMID:12110142
  Authors
Takayanagi H, Kim S, Taniguchi T
  Title
Signaling crosstalk between RANKL and interferons in osteoclast differentiation.
  Journal
Arthritis Res 4 Suppl 3:S227-32 (2002)
DOI:10.1186/ar581
Related
pathway
bbis04010  MAPK signaling pathway
bbis04020  Calcium signaling pathway
bbis04064  NF-kappa B signaling pathway
bbis04151  PI3K-Akt signaling pathway
bbis04630  JAK-STAT signaling pathway
KO pathway
ko04380   

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